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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:FLNA-TIMM23

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: FLNA-TIMM23
FusionPDB ID: 30650
FusionGDB2.0 ID: 30650
HgeneTgene
Gene symbol

FLNA

TIMM23

Gene ID

2316

100287932

Gene namefilamin Atranslocase of inner mitochondrial membrane 23
SynonymsABP-280|ABPX|CSBS|CVD1|FGS2|FLN|FLN-A|FLN1|FMD|MNS|NHBP|OPD|OPD1|OPD2|XLVD|XMVDTIM23
Cytomap

Xq28

10q11.22

Type of geneprotein-codingprotein-coding
Descriptionfilamin-Aactin binding protein 280alpha-filaminendothelial actin-binding proteinepididymis secretory sperm binding proteinfilamin A, alphafilamin-1non-muscle filaminmitochondrial import inner membrane translocase subunit Tim23translocase of inner mitochondrial membrane 23 homologtranslocase of the inner mitochondrial membrane
Modification date2020031320200329
UniProtAcc

P21333

.
Ensembl transtripts involved in fusion geneENST idsENST00000344736, ENST00000360319, 
ENST00000369850, ENST00000369856, 
ENST00000422373, ENST00000498491, 
ENST00000374064, ENST00000374065, 
ENST00000485812, ENST00000260867, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score24 X 29 X 9=62646 X 4 X 5=120
# samples 346
** MAII scorelog2(34/6264*10)=-4.20347756115334
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: FLNA [Title/Abstract] AND TIMM23 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FLNA(153582519)-TIMM23(51612988), # samples:1
Anticipated loss of major functional domain due to fusion event.FLNA-TIMM23 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FLNA-TIMM23 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FLNA-TIMM23 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FLNA-TIMM23 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFLNA

GO:0016479

negative regulation of transcription by RNA polymerase I

22307607

HgeneFLNA

GO:0030334

regulation of cell migration

16291724

HgeneFLNA

GO:0031532

actin cytoskeleton reorganization

10051605

HgeneFLNA

GO:0034394

protein localization to cell surface

18322202

HgeneFLNA

GO:0043113

receptor clustering

10692483

HgeneFLNA

GO:0043433

negative regulation of DNA-binding transcription factor activity

15684392

HgeneFLNA

GO:0044319

wound healing, spreading of cells

16291724

HgeneFLNA

GO:0045184

establishment of protein localization

18322202

HgeneFLNA

GO:0051764

actin crosslink formation

10051605

HgeneFLNA

GO:0072659

protein localization to plasma membrane

24951510

HgeneFLNA

GO:0090307

mitotic spindle assembly

18548008

HgeneFLNA

GO:1901381

positive regulation of potassium ion transmembrane transport

24951510


check buttonFusion gene breakpoints across FLNA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TIMM23 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8365-01AFLNAchrX

153582519

-TIMM23chr10

51612988

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360319FLNAchrX153582519-ENST00000260867TIMM23chr1051612988-63665571259411979
ENST00000422373FLNAchrX153582519-ENST00000260867TIMM23chr1051612988-6577578221361521979
ENST00000369850FLNAchrX153582519-ENST00000260867TIMM23chr1051612988-6589579420161641987
ENST00000369856FLNAchrX153582519-ENST00000260867TIMM23chr1051612988-1612817181187389
ENST00000344736FLNAchrX153582519-ENST00000260867TIMM23chr1051612988-62755480758501947

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360319ENST00000260867FLNAchrX153582519-TIMM23chr1051612988-0.0008073210.99919266
ENST00000422373ENST00000260867FLNAchrX153582519-TIMM23chr1051612988-0.0009517720.9990482
ENST00000369850ENST00000260867FLNAchrX153582519-TIMM23chr1051612988-0.0011925970.99880743
ENST00000369856ENST00000260867FLNAchrX153582519-TIMM23chr1051612988-0.0063907460.9936093
ENST00000344736ENST00000260867FLNAchrX153582519-TIMM23chr1051612988-0.0015883790.99841166

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>30650_30650_1_FLNA-TIMM23_FLNA_chrX_153582519_ENST00000344736_TIMM23_chr10_51612988_ENST00000260867_length(amino acids)=1947AA_BP=1823
MQHRPPGFSRLKMSSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLI
ALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTP
KQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVM
TYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVP
EVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPMGQKGTVEPQLEARG
DSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVTVGQACNPSACRAVGRGLQPKGVRVKETADFKVYTKGAGSGELKVTVKGPKGEERV
KQKDLGDGVYGFEYYPMVPGTYIVTITWGGQNIGRSPFEVKVGTECGNQKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQ
AKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIRDAPQDFHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHGGKAPLR
VQVQDNEGCPVEALVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCAE
AGQGDVSIGIKCAPGVVGPAEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKVEPSHDASKVKAEGPGLSRTGVE
LGKPTHFTVNAKAAGKGKLDVQFSGLTKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGVNVTYGGDPIPKSPFSVAVSPSLDLSKIKVSG
LGEKVDVGKDQEFTVKSKGAGGQGKVASKIVGPSGAAVPCKVEPGLGADNSVVRFLPREEGPYEVEVTYDGVPVPGSPFPLEAVAPTKPS
KVKAFGPGLQGGSAGSPARFTIDTKGAGTGGLGLTVEGPCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCF
DASKVKCSGPGLERATAGEVGQFQVDCSSAGSAELTIEICSEAGLPAEVYIQDHGDGTHTITYIPLCPGAYTVTIKYGGQPVPNFPSKLQ
VEPAVDTSGVQCYGPGIEGQGVFREATTEFSVDARALTQTGGPHVKARVANPSGNLTETYVQDRGDGMYKVEYTPYEEGLHSVDVTYDGS
PVPSSPFQVPVTEGCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPSEAKMSCMDNKDGSCSVEYIPYEAGTYSLNVTY
GGHQVPGSPFKVPVHDVTDASKVKCSGPGLSPGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGP
YSISVLYGDEEVPRSPFKVKVLPTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEGLLAVQITDPEGKPKKTHIQDNHDGTYTVAY
VPDVTGRYTILIKYGGDEIPFSPYRVRAVPTGDASKCTVTGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVENEDG
TFDIFYTAPQPGKYVICVRFGGEHVPNSPFQVTAPERPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPTITDNKDGTV
TVRYAPSEAGLHEMDIRYDNMHIPGAAFGAMNGLRLGLKETQNMAWSKPRNVQILNMVTRQGALWANTLGSLALLYSAFGVIIEKTRGAE

--------------------------------------------------------------

>30650_30650_2_FLNA-TIMM23_FLNA_chrX_153582519_ENST00000360319_TIMM23_chr10_51612988_ENST00000260867_length(amino acids)=1979AA_BP=1855
LQHRPPGFSRLKMSSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLI
ALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTP
KQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVM
TYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVP
EVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPMGQKGTVEPQLEARG
DSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVTVGQACNPSACRAVGRGLQPKGVRVKETADFKVYTKGAGSGELKVTVKGPKGEERV
KQKDLGDGVYGFEYYPMVPGTYIVTITWGGQNIGRSPFEVKVGTECGNQKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQ
AKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIRDAPQDFHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHGGKAPLR
VQVQDNEGCPVEALVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCAE
AGQGDVSIGIKCAPGVVGPAEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKVEPSHDASKVKAEGPGLSRTGVE
LGKPTHFTVNAKAAGKGKLDVQFSGLTKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGVNVTYGGDPIPKSPFSVAVSPSLDLSKIKVSG
LGEKVDVGKDQEFTVKSKGAGGQGKVASKIVGPSGAAVPCKVEPGLGADNSVVRFLPREEGPYEVEVTYDGVPVPGSPFPLEAVAPTKPS
KVKAFGPGLQGGSAGSPARFTIDTKGAGTGGLGLTVEGPCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCF
DASKVKCSGPGLERATAGEVGQFQVDCSSAGSAELTIEICSEAGLPAEVYIQDHGDGTHTITYIPLCPGAYTVTIKYGGQPVPNFPSKLQ
VEPAVDTSGVQCYGPGIEGQGVFREATTEFSVDARALTQTGGPHVKARVANPSGNLTETYVQDRGDGMYKVEYTPYEEGLHSVDVTYDGS
PVPSSPFQVPVTEGCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPSEAKMSCMDNKDGSCSVEYIPYEAGTYSLNVTY
GGHQVPGSPFKVPVHDVTDASKVKCSGPGLSPGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGP
YSISVLYGDEEVPRSPFKVKVLPTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEGLLAVQITDPEGKPKKTHIQDNHDGTYTVAY
VPDVTGRYTILIKYGGDEIPFSPYRVRAVPTGDASKCTVTGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVENEDG
TFDIFYTAPQPGKYVICVRFGGEHVPNSPFQVTALAGDQPSVQPPLRSQQLAPQYTYAQGGQQTWAPERPLVGVNGLDVTSLRPFDLVIP
FTIKKGEITGEVRMPSGKVAQPTITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGAAFGAMNGLRLGLKETQNMAWSKPRNVQILNMV

--------------------------------------------------------------

>30650_30650_3_FLNA-TIMM23_FLNA_chrX_153582519_ENST00000369850_TIMM23_chr10_51612988_ENST00000260867_length(amino acids)=1987AA_BP=1863
MQHRPPGFSRLKMSSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLI
ALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTP
KQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVM
TYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVP
EVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPMGQKGTVEPQLEARG
DSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVTVGQACNPSACRAVGRGLQPKGVRVKETADFKVYTKGAGSGELKVTVKGPKGEERV
KQKDLGDGVYGFEYYPMVPGTYIVTITWGGQNIGRSPFEVKVGTECGNQKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQ
AKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIRDAPQDFHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHGGKAPLR
VQVQDNEGCPVEALVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCAE
AGQGDVSIGIKCAPGVVGPAEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKVEPSHDASKVKAEGPGLSRTGVE
LGKPTHFTVNAKAAGKGKLDVQFSGLTKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGVNVTYGGDPIPKSPFSVAVSPSLDLSKIKVSG
LGEKVDVGKDQEFTVKSKGAGGQGKVASKIVGPSGAAVPCKVEPGLGADNSVVRFLPREEGPYEVEVTYDGVPVPGSPFPLEAVAPTKPS
KVKAFGPGLQGGSAGSPARFTIDTKGAGTGGLGLTVEGPCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCF
DASKVKCSGPGLERATAGEVGQFQVDCSSAGSAELTIEICSEAGLPAEVYIQDHGDGTHTITYIPLCPGAYTVTIKYGGQPVPNFPSKLQ
VEPAVDTSGVQCYGPGIEGQGVFREATTEFSVDARALTQTGGPHVKARVANPSGNLTETYVQDRGDGMYKVEYTPYEEGLHSVDVTYDGS
PVPSSPFQVPVTEGCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPSEAKMSCMDNKDGSCSVEYIPYEAGTYSLNVTY
GGHQVPGSPFKVPVHDVTDASKVKCSGPGLSPGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGP
YSISVLYGDEEVPRSPFKVKVLPTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEGLLAVQITDPEGKPKKTHIQDNHDGTYTVAY
VPDVTGRYTILIKYGGDEIPFSPYRVRAVPTGDASKCTVTVSIGGHGLGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDV
DVVENEDGTFDIFYTAPQPGKYVICVRFGGEHVPNSPFQVTALAGDQPSVQPPLRSQQLAPQYTYAQGGQQTWAPERPLVGVNGLDVTSL
RPFDLVIPFTIKKGEITGEVRMPSGKVAQPTITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGAAFGAMNGLRLGLKETQNMAWSKPR
NVQILNMVTRQGALWANTLGSLALLYSAFGVIIEKTRGAEDDLNTVAAGTMTGMLYKCTGGLRGIARGGLTGLTLTSLYALYNNWEHMKG

--------------------------------------------------------------

>30650_30650_4_FLNA-TIMM23_FLNA_chrX_153582519_ENST00000369856_TIMM23_chr10_51612988_ENST00000260867_length(amino acids)=389AA_BP=265
MLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAVPTGDASKCTVTGAGIGPTIQIGEETVITVDT
KAAGKGKVTCTVCTPDGSEVDVDVVENEDGTFDIFYTAPQPGKYVICVRFGGEHVPNSPFQVTALAGDQPSVQPPLRSQQLAPQYTYAQG
GQQTWAPERPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPTITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGAAF
GAMNGLRLGLKETQNMAWSKPRNVQILNMVTRQGALWANTLGSLALLYSAFGVIIEKTRGAEDDLNTVAAGTMTGMLYKCTGGLRGIARG

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>30650_30650_5_FLNA-TIMM23_FLNA_chrX_153582519_ENST00000422373_TIMM23_chr10_51612988_ENST00000260867_length(amino acids)=1979AA_BP=1855
MQHRPPGFSRLKMSSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLI
ALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTP
KQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVM
TYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVP
EVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPMGQKGTVEPQLEARG
DSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVTVGQACNPSACRAVGRGLQPKGVRVKETADFKVYTKGAGSGELKVTVKGPKGEERV
KQKDLGDGVYGFEYYPMVPGTYIVTITWGGQNIGRSPFEVKVGTECGNQKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQ
AKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIRDAPQDFHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHGGKAPLR
VQVQDNEGCPVEALVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCAE
AGQGDVSIGIKCAPGVVGPAEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKVEPSHDASKVKAEGPGLSRTGVE
LGKPTHFTVNAKAAGKGKLDVQFSGLTKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGVNVTYGGDPIPKSPFSVAVSPSLDLSKIKVSG
LGEKVDVGKDQEFTVKSKGAGGQGKVASKIVGPSGAAVPCKVEPGLGADNSVVRFLPREEGPYEVEVTYDGVPVPGSPFPLEAVAPTKPS
KVKAFGPGLQGGSAGSPARFTIDTKGAGTGGLGLTVEGPCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCF
DASKVKCSGPGLERATAGEVGQFQVDCSSAGSAELTIEICSEAGLPAEVYIQDHGDGTHTITYIPLCPGAYTVTIKYGGQPVPNFPSKLQ
VEPAVDTSGVQCYGPGIEGQGVFREATTEFSVDARALTQTGGPHVKARVANPSGNLTETYVQDRGDGMYKVEYTPYEEGLHSVDVTYDGS
PVPSSPFQVPVTEGCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPSEAKMSCMDNKDGSCSVEYIPYEAGTYSLNVTY
GGHQVPGSPFKVPVHDVTDASKVKCSGPGLSPGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGP
YSISVLYGDEEVPRSPFKVKVLPTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEGLLAVQITDPEGKPKKTHIQDNHDGTYTVAY
VPDVTGRYTILIKYGGDEIPFSPYRVRAVPTGDASKCTVTGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVENEDG
TFDIFYTAPQPGKYVICVRFGGEHVPNSPFQVTALAGDQPSVQPPLRSQQLAPQYTYAQGGQQTWAPERPLVGVNGLDVTSLRPFDLVIP
FTIKKGEITGEVRMPSGKVAQPTITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGAAFGAMNGLRLGLKETQNMAWSKPRNVQILNMV

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:153582519/chr10:51612988)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FLNA

P21333

.
FUNCTION: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFLNAchrX:153582519chr10:51612988ENST00000360319-3246166_2691844.33333333333332640.0DomainCalponin-homology (CH) 2
HgeneFLNAchrX:153582519chr10:51612988ENST00000360319-324643_1491844.33333333333332640.0DomainCalponin-homology (CH) 1
HgeneFLNAchrX:153582519chr10:51612988ENST00000369850-3448166_2691852.33333333333332648.0DomainCalponin-homology (CH) 2
HgeneFLNAchrX:153582519chr10:51612988ENST00000369850-344843_1491852.33333333333332648.0DomainCalponin-homology (CH) 1
HgeneFLNAchrX:153582519chr10:51612988ENST00000422373-3347166_2691844.33333333333332640.0DomainCalponin-homology (CH) 2
HgeneFLNAchrX:153582519chr10:51612988ENST00000422373-334743_1491844.33333333333332640.0DomainCalponin-homology (CH) 1
HgeneFLNAchrX:153582519chr10:51612988ENST00000360319-32461741_17781844.33333333333332640.0RegionNote=Hinge 1
HgeneFLNAchrX:153582519chr10:51612988ENST00000360319-32462_2741844.33333333333332640.0RegionNote=Actin-binding
HgeneFLNAchrX:153582519chr10:51612988ENST00000369850-34481741_17781852.33333333333332648.0RegionNote=Hinge 1
HgeneFLNAchrX:153582519chr10:51612988ENST00000369850-34482_2741852.33333333333332648.0RegionNote=Actin-binding
HgeneFLNAchrX:153582519chr10:51612988ENST00000422373-33471741_17781844.33333333333332640.0RegionNote=Hinge 1
HgeneFLNAchrX:153582519chr10:51612988ENST00000422373-33472_2741844.33333333333332640.0RegionNote=Actin-binding
HgeneFLNAchrX:153582519chr10:51612988ENST00000360319-32461062_11541844.33333333333332640.0RepeatNote=Filamin 9
HgeneFLNAchrX:153582519chr10:51612988ENST00000360319-32461155_12491844.33333333333332640.0RepeatNote=Filamin 10
HgeneFLNAchrX:153582519chr10:51612988ENST00000360319-32461250_13491844.33333333333332640.0RepeatNote=Filamin 11
HgeneFLNAchrX:153582519chr10:51612988ENST00000360319-32461350_14421844.33333333333332640.0RepeatNote=Filamin 12
HgeneFLNAchrX:153582519chr10:51612988ENST00000360319-32461443_15391844.33333333333332640.0RepeatNote=Filamin 13
HgeneFLNAchrX:153582519chr10:51612988ENST00000360319-32461540_16361844.33333333333332640.0RepeatNote=Filamin 14
HgeneFLNAchrX:153582519chr10:51612988ENST00000360319-32461649_17401844.33333333333332640.0RepeatNote=Filamin 15
HgeneFLNAchrX:153582519chr10:51612988ENST00000360319-3246276_3741844.33333333333332640.0RepeatNote=Filamin 1
HgeneFLNAchrX:153582519chr10:51612988ENST00000360319-3246376_4741844.33333333333332640.0RepeatNote=Filamin 2
HgeneFLNAchrX:153582519chr10:51612988ENST00000360319-3246475_5701844.33333333333332640.0RepeatNote=Filamin 3
HgeneFLNAchrX:153582519chr10:51612988ENST00000360319-3246571_6631844.33333333333332640.0RepeatNote=Filamin 4
HgeneFLNAchrX:153582519chr10:51612988ENST00000360319-3246667_7631844.33333333333332640.0RepeatNote=Filamin 5
HgeneFLNAchrX:153582519chr10:51612988ENST00000360319-3246764_8661844.33333333333332640.0RepeatNote=Filamin 6
HgeneFLNAchrX:153582519chr10:51612988ENST00000360319-3246867_9651844.33333333333332640.0RepeatNote=Filamin 7
HgeneFLNAchrX:153582519chr10:51612988ENST00000360319-3246966_10611844.33333333333332640.0RepeatNote=Filamin 8
HgeneFLNAchrX:153582519chr10:51612988ENST00000369850-34481062_11541852.33333333333332648.0RepeatNote=Filamin 9
HgeneFLNAchrX:153582519chr10:51612988ENST00000369850-34481155_12491852.33333333333332648.0RepeatNote=Filamin 10
HgeneFLNAchrX:153582519chr10:51612988ENST00000369850-34481250_13491852.33333333333332648.0RepeatNote=Filamin 11
HgeneFLNAchrX:153582519chr10:51612988ENST00000369850-34481350_14421852.33333333333332648.0RepeatNote=Filamin 12
HgeneFLNAchrX:153582519chr10:51612988ENST00000369850-34481443_15391852.33333333333332648.0RepeatNote=Filamin 13
HgeneFLNAchrX:153582519chr10:51612988ENST00000369850-34481540_16361852.33333333333332648.0RepeatNote=Filamin 14
HgeneFLNAchrX:153582519chr10:51612988ENST00000369850-34481649_17401852.33333333333332648.0RepeatNote=Filamin 15
HgeneFLNAchrX:153582519chr10:51612988ENST00000369850-3448276_3741852.33333333333332648.0RepeatNote=Filamin 1
HgeneFLNAchrX:153582519chr10:51612988ENST00000369850-3448376_4741852.33333333333332648.0RepeatNote=Filamin 2
HgeneFLNAchrX:153582519chr10:51612988ENST00000369850-3448475_5701852.33333333333332648.0RepeatNote=Filamin 3
HgeneFLNAchrX:153582519chr10:51612988ENST00000369850-3448571_6631852.33333333333332648.0RepeatNote=Filamin 4
HgeneFLNAchrX:153582519chr10:51612988ENST00000369850-3448667_7631852.33333333333332648.0RepeatNote=Filamin 5
HgeneFLNAchrX:153582519chr10:51612988ENST00000369850-3448764_8661852.33333333333332648.0RepeatNote=Filamin 6
HgeneFLNAchrX:153582519chr10:51612988ENST00000369850-3448867_9651852.33333333333332648.0RepeatNote=Filamin 7
HgeneFLNAchrX:153582519chr10:51612988ENST00000369850-3448966_10611852.33333333333332648.0RepeatNote=Filamin 8
HgeneFLNAchrX:153582519chr10:51612988ENST00000422373-33471062_11541844.33333333333332640.0RepeatNote=Filamin 9
HgeneFLNAchrX:153582519chr10:51612988ENST00000422373-33471155_12491844.33333333333332640.0RepeatNote=Filamin 10
HgeneFLNAchrX:153582519chr10:51612988ENST00000422373-33471250_13491844.33333333333332640.0RepeatNote=Filamin 11
HgeneFLNAchrX:153582519chr10:51612988ENST00000422373-33471350_14421844.33333333333332640.0RepeatNote=Filamin 12
HgeneFLNAchrX:153582519chr10:51612988ENST00000422373-33471443_15391844.33333333333332640.0RepeatNote=Filamin 13
HgeneFLNAchrX:153582519chr10:51612988ENST00000422373-33471540_16361844.33333333333332640.0RepeatNote=Filamin 14
HgeneFLNAchrX:153582519chr10:51612988ENST00000422373-33471649_17401844.33333333333332640.0RepeatNote=Filamin 15
HgeneFLNAchrX:153582519chr10:51612988ENST00000422373-3347276_3741844.33333333333332640.0RepeatNote=Filamin 1
HgeneFLNAchrX:153582519chr10:51612988ENST00000422373-3347376_4741844.33333333333332640.0RepeatNote=Filamin 2
HgeneFLNAchrX:153582519chr10:51612988ENST00000422373-3347475_5701844.33333333333332640.0RepeatNote=Filamin 3
HgeneFLNAchrX:153582519chr10:51612988ENST00000422373-3347571_6631844.33333333333332640.0RepeatNote=Filamin 4
HgeneFLNAchrX:153582519chr10:51612988ENST00000422373-3347667_7631844.33333333333332640.0RepeatNote=Filamin 5
HgeneFLNAchrX:153582519chr10:51612988ENST00000422373-3347764_8661844.33333333333332640.0RepeatNote=Filamin 6
HgeneFLNAchrX:153582519chr10:51612988ENST00000422373-3347867_9651844.33333333333332640.0RepeatNote=Filamin 7
HgeneFLNAchrX:153582519chr10:51612988ENST00000422373-3347966_10611844.33333333333332640.0RepeatNote=Filamin 8
TgeneTIMM23chrX:153582519chr10:51612988ENST0000026086727125_14586.33333333333333210.0TransmembraneHelical
TgeneTIMM23chrX:153582519chr10:51612988ENST0000026086727181_19786.33333333333333210.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFLNAchrX:153582519chr10:51612988ENST00000360319-32462517_25511844.33333333333332640.0RegionNote=Hinge 2
HgeneFLNAchrX:153582519chr10:51612988ENST00000360319-32462517_26471844.33333333333332640.0RegionNote=Self-association site%2C tail
HgeneFLNAchrX:153582519chr10:51612988ENST00000369850-34482517_25511852.33333333333332648.0RegionNote=Hinge 2
HgeneFLNAchrX:153582519chr10:51612988ENST00000369850-34482517_26471852.33333333333332648.0RegionNote=Self-association site%2C tail
HgeneFLNAchrX:153582519chr10:51612988ENST00000422373-33472517_25511844.33333333333332640.0RegionNote=Hinge 2
HgeneFLNAchrX:153582519chr10:51612988ENST00000422373-33472517_26471844.33333333333332640.0RegionNote=Self-association site%2C tail
HgeneFLNAchrX:153582519chr10:51612988ENST00000360319-32461779_18601844.33333333333332640.0RepeatNote=Filamin 16
HgeneFLNAchrX:153582519chr10:51612988ENST00000360319-32461861_19501844.33333333333332640.0RepeatNote=Filamin 17
HgeneFLNAchrX:153582519chr10:51612988ENST00000360319-32461951_20391844.33333333333332640.0RepeatNote=Filamin 18
HgeneFLNAchrX:153582519chr10:51612988ENST00000360319-32462042_21311844.33333333333332640.0RepeatNote=Filamin 19
HgeneFLNAchrX:153582519chr10:51612988ENST00000360319-32462132_22301844.33333333333332640.0RepeatNote=Filamin 20
HgeneFLNAchrX:153582519chr10:51612988ENST00000360319-32462233_23251844.33333333333332640.0RepeatNote=Filamin 21
HgeneFLNAchrX:153582519chr10:51612988ENST00000360319-32462327_24201844.33333333333332640.0RepeatNote=Filamin 22
HgeneFLNAchrX:153582519chr10:51612988ENST00000360319-32462424_25161844.33333333333332640.0RepeatNote=Filamin 23
HgeneFLNAchrX:153582519chr10:51612988ENST00000360319-32462552_26461844.33333333333332640.0RepeatNote=Filamin 24
HgeneFLNAchrX:153582519chr10:51612988ENST00000369850-34481779_18601852.33333333333332648.0RepeatNote=Filamin 16
HgeneFLNAchrX:153582519chr10:51612988ENST00000369850-34481861_19501852.33333333333332648.0RepeatNote=Filamin 17
HgeneFLNAchrX:153582519chr10:51612988ENST00000369850-34481951_20391852.33333333333332648.0RepeatNote=Filamin 18
HgeneFLNAchrX:153582519chr10:51612988ENST00000369850-34482042_21311852.33333333333332648.0RepeatNote=Filamin 19
HgeneFLNAchrX:153582519chr10:51612988ENST00000369850-34482132_22301852.33333333333332648.0RepeatNote=Filamin 20
HgeneFLNAchrX:153582519chr10:51612988ENST00000369850-34482233_23251852.33333333333332648.0RepeatNote=Filamin 21
HgeneFLNAchrX:153582519chr10:51612988ENST00000369850-34482327_24201852.33333333333332648.0RepeatNote=Filamin 22
HgeneFLNAchrX:153582519chr10:51612988ENST00000369850-34482424_25161852.33333333333332648.0RepeatNote=Filamin 23
HgeneFLNAchrX:153582519chr10:51612988ENST00000369850-34482552_26461852.33333333333332648.0RepeatNote=Filamin 24
HgeneFLNAchrX:153582519chr10:51612988ENST00000422373-33471779_18601844.33333333333332640.0RepeatNote=Filamin 16
HgeneFLNAchrX:153582519chr10:51612988ENST00000422373-33471861_19501844.33333333333332640.0RepeatNote=Filamin 17
HgeneFLNAchrX:153582519chr10:51612988ENST00000422373-33471951_20391844.33333333333332640.0RepeatNote=Filamin 18
HgeneFLNAchrX:153582519chr10:51612988ENST00000422373-33472042_21311844.33333333333332640.0RepeatNote=Filamin 19
HgeneFLNAchrX:153582519chr10:51612988ENST00000422373-33472132_22301844.33333333333332640.0RepeatNote=Filamin 20
HgeneFLNAchrX:153582519chr10:51612988ENST00000422373-33472233_23251844.33333333333332640.0RepeatNote=Filamin 21
HgeneFLNAchrX:153582519chr10:51612988ENST00000422373-33472327_24201844.33333333333332640.0RepeatNote=Filamin 22
HgeneFLNAchrX:153582519chr10:51612988ENST00000422373-33472424_25161844.33333333333332640.0RepeatNote=Filamin 23
HgeneFLNAchrX:153582519chr10:51612988ENST00000422373-33472552_26461844.33333333333332640.0RepeatNote=Filamin 24
TgeneTIMM23chrX:153582519chr10:51612988ENST000002608672773_9386.33333333333333210.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
FLNA
TIMM23


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to FLNA-TIMM23


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to FLNA-TIMM23


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource