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Fusion Protein:FOXN3-KCNQ1 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: FOXN3-KCNQ1 | FusionPDB ID: 31143 | FusionGDB2.0 ID: 31143 | Hgene | Tgene | Gene symbol | FOXN3 | KCNQ1 | Gene ID | 1112 | 3784 |
| Gene name | forkhead box N3 | potassium voltage-gated channel subfamily Q member 1 | |
| Synonyms | C14orf116|CHES1|PRO1635 | ATFB1|ATFB3|JLNS1|KCNA8|KCNA9|KVLQT1|Kv1.9|Kv7.1|LQT|LQT1|RWS|SQT2|WRS | |
| Cytomap | 14q31.3-q32.11 | 11p15.5-p15.4 | |
| Type of gene | protein-coding | protein-coding | |
| Description | forkhead box protein N3checkpoint suppressor 1 | potassium voltage-gated channel subfamily KQT member 1IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1kidney and cardiac voltage dependend K+ channelpotassium channel, voltage gated KQT-like subfamily Q, member 1potassium voltag | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | O00409 | P51787 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000261302, ENST00000345097, ENST00000555353, ENST00000557258, ENST00000555658, | ENST00000526095, ENST00000155840, ENST00000335475, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 21 X 18 X 8=3024 | 10 X 10 X 5=500 |
| # samples | 22 | 12 | |
| ** MAII score | log2(22/3024*10)=-3.78088271069641 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/500*10)=-2.05889368905357 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: FOXN3 [Title/Abstract] AND KCNQ1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | FOXN3(89747294)-KCNQ1(2790074), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | FOXN3-KCNQ1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FOXN3-KCNQ1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FOXN3-KCNQ1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. FOXN3-KCNQ1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. FOXN3-KCNQ1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. FOXN3-KCNQ1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. FOXN3-KCNQ1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FOXN3 | GO:0045892 | negative regulation of transcription, DNA-templated | 16102918 |
| Tgene | KCNQ1 | GO:0035690 | cellular response to drug | 9108097 |
| Tgene | KCNQ1 | GO:0060306 | regulation of membrane repolarization | 11299204 |
| Tgene | KCNQ1 | GO:0071320 | cellular response to cAMP | 11299204|16002409 |
| Tgene | KCNQ1 | GO:0071805 | potassium ion transmembrane transport | 9354802|11299204|16002409 |
| Tgene | KCNQ1 | GO:0086011 | membrane repolarization during action potential | 8900283|11299204|19646991 |
| Tgene | KCNQ1 | GO:0097623 | potassium ion export across plasma membrane | 8900283|10400998|17289006 |
| Tgene | KCNQ1 | GO:1901381 | positive regulation of potassium ion transmembrane transport | 8900283 |
| Fusion gene breakpoints across FOXN3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across KCNQ1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | PRAD | TCGA-V1-A8MG-01A | FOXN3 | chr14 | 89747294 | - | KCNQ1 | chr11 | 2790074 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000345097 | FOXN3 | chr14 | 89747294 | - | ENST00000155840 | KCNQ1 | chr11 | 2790074 | + | 2485 | 862 | 117 | 1124 | 335 |
| ENST00000345097 | FOXN3 | chr14 | 89747294 | - | ENST00000335475 | KCNQ1 | chr11 | 2790074 | + | 1614 | 862 | 117 | 1124 | 335 |
| ENST00000555353 | FOXN3 | chr14 | 89747294 | - | ENST00000155840 | KCNQ1 | chr11 | 2790074 | + | 2504 | 881 | 136 | 1143 | 335 |
| ENST00000555353 | FOXN3 | chr14 | 89747294 | - | ENST00000335475 | KCNQ1 | chr11 | 2790074 | + | 1633 | 881 | 136 | 1143 | 335 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000345097 | ENST00000155840 | FOXN3 | chr14 | 89747294 | - | KCNQ1 | chr11 | 2790074 | + | 0.27526158 | 0.7247384 |
| ENST00000345097 | ENST00000335475 | FOXN3 | chr14 | 89747294 | - | KCNQ1 | chr11 | 2790074 | + | 0.2313771 | 0.76862293 |
| ENST00000555353 | ENST00000155840 | FOXN3 | chr14 | 89747294 | - | KCNQ1 | chr11 | 2790074 | + | 0.2722526 | 0.72774744 |
| ENST00000555353 | ENST00000335475 | FOXN3 | chr14 | 89747294 | - | KCNQ1 | chr11 | 2790074 | + | 0.21302658 | 0.7869734 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >31143_31143_1_FOXN3-KCNQ1_FOXN3_chr14_89747294_ENST00000345097_KCNQ1_chr11_2790074_ENST00000155840_length(amino acids)=335AA_BP=248 MGPVMPPSKKPESSGISVSSGLSQCYGGSGFSKALQEDDDLDFSLPDIRLEEGAMEDEELTNLNWLHESKNLLKSFGESVLRSVSPVQDL DDDTPPSPAHSDMPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERS QSIGKGSLWCIDPEYRQNLIQALKKTPYHPHPHVFNTPPTCPQAYQSTSGPPIWPGSTFFKRNGALLQGCGNTIGPPLRSFDACSTLWPR -------------------------------------------------------------- >31143_31143_2_FOXN3-KCNQ1_FOXN3_chr14_89747294_ENST00000345097_KCNQ1_chr11_2790074_ENST00000335475_length(amino acids)=335AA_BP=248 MGPVMPPSKKPESSGISVSSGLSQCYGGSGFSKALQEDDDLDFSLPDIRLEEGAMEDEELTNLNWLHESKNLLKSFGESVLRSVSPVQDL DDDTPPSPAHSDMPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERS QSIGKGSLWCIDPEYRQNLIQALKKTPYHPHPHVFNTPPTCPQAYQSTSGPPIWPGSTFFKRNGALLQGCGNTIGPPLRSFDACSTLWPR -------------------------------------------------------------- >31143_31143_3_FOXN3-KCNQ1_FOXN3_chr14_89747294_ENST00000555353_KCNQ1_chr11_2790074_ENST00000155840_length(amino acids)=335AA_BP=248 MGPVMPPSKKPESSGISVSSGLSQCYGGSGFSKALQEDDDLDFSLPDIRLEEGAMEDEELTNLNWLHESKNLLKSFGESVLRSVSPVQDL DDDTPPSPAHSDMPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERS QSIGKGSLWCIDPEYRQNLIQALKKTPYHPHPHVFNTPPTCPQAYQSTSGPPIWPGSTFFKRNGALLQGCGNTIGPPLRSFDACSTLWPR -------------------------------------------------------------- >31143_31143_4_FOXN3-KCNQ1_FOXN3_chr14_89747294_ENST00000555353_KCNQ1_chr11_2790074_ENST00000335475_length(amino acids)=335AA_BP=248 MGPVMPPSKKPESSGISVSSGLSQCYGGSGFSKALQEDDDLDFSLPDIRLEEGAMEDEELTNLNWLHESKNLLKSFGESVLRSVSPVQDL DDDTPPSPAHSDMPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERS QSIGKGSLWCIDPEYRQNLIQALKKTPYHPHPHVFNTPPTCPQAYQSTSGPPIWPGSTFFKRNGALLQGCGNTIGPPLRSFDACSTLWPR -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:89747294/chr11:2790074) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FOXN3 | KCNQ1 |
| FUNCTION: Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints). {ECO:0000269|PubMed:16102918}. | FUNCTION: Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (PubMed:10646604, PubMed:25441029). Associates with KCNE beta subunits that modulates current kinetics (PubMed:9312006, PubMed:9108097, PubMed:8900283, PubMed:10646604, PubMed:11101505, PubMed:19687231). Induces a voltage-dependent current by rapidly activating and slowly deactivating potassium-selective outward current (PubMed:9312006, PubMed:9108097, PubMed:8900283, PubMed:10646604, PubMed:11101505, PubMed:25441029). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac repolarization by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (By similarity) (PubMed:9312006, PubMed:9108097, PubMed:8900283, PubMed:10646604, PubMed:11101505). Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current (PubMed:10713961). When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (PubMed:10646604). This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents (By similarity). During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion (By similarity). Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion (By similarity). When associated with KCNE2, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505). When associated with KCNE4, inhibits voltage-gated potassium channel activity (PubMed:19687231). When associated with KCNE5, this complex only conducts current upon strong and continued depolarization (PubMed:12324418). Also forms a heterotetramer with KCNQ5; has a voltage-gated potassium channel activity (PubMed:24855057). Binds with phosphatidylinositol 4,5-bisphosphate (PubMed:25037568). {ECO:0000250|UniProtKB:P97414, ECO:0000250|UniProtKB:Q9Z0N7, ECO:0000269|PubMed:10646604, ECO:0000269|PubMed:10713961, ECO:0000269|PubMed:11101505, ECO:0000269|PubMed:12324418, ECO:0000269|PubMed:19687231, ECO:0000269|PubMed:24855057, ECO:0000269|PubMed:25037568, ECO:0000269|PubMed:8900283, ECO:0000269|PubMed:9108097, ECO:0000269|PubMed:9312006}.; FUNCTION: [Isoform 2]: Non-functional alone but modulatory when coexpressed with the full-length isoform 1. {ECO:0000269|PubMed:9305853}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | FOXN3 | chr14:89747294 | chr11:2790074 | ENST00000261302 | - | 3 | 6 | 113_204 | 248.33333333333334 | 491.0 | DNA binding | Fork-head |
| Hgene | FOXN3 | chr14:89747294 | chr11:2790074 | ENST00000345097 | - | 4 | 7 | 113_204 | 248.33333333333334 | 491.0 | DNA binding | Fork-head |
| Hgene | FOXN3 | chr14:89747294 | chr11:2790074 | ENST00000555353 | - | 4 | 6 | 113_204 | 248.33333333333334 | 469.0 | DNA binding | Fork-head |
| Hgene | FOXN3 | chr14:89747294 | chr11:2790074 | ENST00000557258 | - | 4 | 6 | 113_204 | 248.33333333333334 | 469.0 | DNA binding | Fork-head |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000155840 | 10 | 16 | 585_621 | 504.6666666666667 | 677.0 | Coiled coil | Ontology_term=ECO:0000269 | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000335475 | 10 | 16 | 585_621 | 377.6666666666667 | 550.0 | Coiled coil | Ontology_term=ECO:0000269 | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000155840 | 10 | 16 | 589_620 | 504.6666666666667 | 677.0 | Region | C-terminal assembly domain | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000335475 | 10 | 16 | 589_620 | 377.6666666666667 | 550.0 | Region | C-terminal assembly domain |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000155840 | 10 | 16 | 300_320 | 504.6666666666667 | 677.0 | Intramembrane | Pore-forming%3B Name%3DSegment H5 | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000335475 | 10 | 16 | 300_320 | 377.6666666666667 | 550.0 | Intramembrane | Pore-forming%3B Name%3DSegment H5 | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000155840 | 10 | 16 | 312_317 | 504.6666666666667 | 677.0 | Motif | Selectivity filter | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000335475 | 10 | 16 | 312_317 | 377.6666666666667 | 550.0 | Motif | Selectivity filter | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000155840 | 10 | 16 | 143_147 | 504.6666666666667 | 677.0 | Topological domain | Extracellular | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000155840 | 10 | 16 | 169_196 | 504.6666666666667 | 677.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000155840 | 10 | 16 | 1_121 | 504.6666666666667 | 677.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000155840 | 10 | 16 | 218_225 | 504.6666666666667 | 677.0 | Topological domain | Extracellular | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000155840 | 10 | 16 | 249_261 | 504.6666666666667 | 677.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000155840 | 10 | 16 | 283_299 | 504.6666666666667 | 677.0 | Topological domain | Extracellular | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000155840 | 10 | 16 | 321_327 | 504.6666666666667 | 677.0 | Topological domain | Extracellular | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000155840 | 10 | 16 | 349_676 | 504.6666666666667 | 677.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000335475 | 10 | 16 | 143_147 | 377.6666666666667 | 550.0 | Topological domain | Extracellular | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000335475 | 10 | 16 | 169_196 | 377.6666666666667 | 550.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000335475 | 10 | 16 | 1_121 | 377.6666666666667 | 550.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000335475 | 10 | 16 | 218_225 | 377.6666666666667 | 550.0 | Topological domain | Extracellular | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000335475 | 10 | 16 | 249_261 | 377.6666666666667 | 550.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000335475 | 10 | 16 | 283_299 | 377.6666666666667 | 550.0 | Topological domain | Extracellular | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000335475 | 10 | 16 | 321_327 | 377.6666666666667 | 550.0 | Topological domain | Extracellular | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000335475 | 10 | 16 | 349_676 | 377.6666666666667 | 550.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000155840 | 10 | 16 | 122_142 | 504.6666666666667 | 677.0 | Transmembrane | Helical%3B Name%3DSegment S1 | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000155840 | 10 | 16 | 148_168 | 504.6666666666667 | 677.0 | Transmembrane | Helical%3B Name%3DSegment S2 | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000155840 | 10 | 16 | 197_217 | 504.6666666666667 | 677.0 | Transmembrane | Helical%3B Name%3DSegment S3 | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000155840 | 10 | 16 | 226_248 | 504.6666666666667 | 677.0 | Transmembrane | Helical%3B Voltage-sensor%3B Name%3DSegment S4 | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000155840 | 10 | 16 | 262_282 | 504.6666666666667 | 677.0 | Transmembrane | Helical%3B Name%3DSegment S5 | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000155840 | 10 | 16 | 328_348 | 504.6666666666667 | 677.0 | Transmembrane | Helical%3B Name%3DSegment S6 | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000335475 | 10 | 16 | 122_142 | 377.6666666666667 | 550.0 | Transmembrane | Helical%3B Name%3DSegment S1 | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000335475 | 10 | 16 | 148_168 | 377.6666666666667 | 550.0 | Transmembrane | Helical%3B Name%3DSegment S2 | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000335475 | 10 | 16 | 197_217 | 377.6666666666667 | 550.0 | Transmembrane | Helical%3B Name%3DSegment S3 | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000335475 | 10 | 16 | 226_248 | 377.6666666666667 | 550.0 | Transmembrane | Helical%3B Voltage-sensor%3B Name%3DSegment S4 | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000335475 | 10 | 16 | 262_282 | 377.6666666666667 | 550.0 | Transmembrane | Helical%3B Name%3DSegment S5 | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000335475 | 10 | 16 | 328_348 | 377.6666666666667 | 550.0 | Transmembrane | Helical%3B Name%3DSegment S6 |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| FOXN3 | |
| KCNQ1 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000155840 | 10 | 16 | 370_382 | 504.6666666666667 | 677.0 | CALM | |
| Tgene | KCNQ1 | chr14:89747294 | chr11:2790074 | ENST00000335475 | 10 | 16 | 370_382 | 377.6666666666667 | 550.0 | CALM |
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Related Drugs to FOXN3-KCNQ1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to FOXN3-KCNQ1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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