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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:FOXO3-PPP1R9A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: FOXO3-PPP1R9A
FusionPDB ID: 31181
FusionGDB2.0 ID: 31181
HgeneTgene
Gene symbol

FOXO3

PPP1R9A

Gene ID

2309

55607

Gene nameforkhead box O3protein phosphatase 1 regulatory subunit 9A
SynonymsAF6q21|FKHRL1|FKHRL1P2|FOXO2|FOXO3ANRB1|NRBI|Neurabin-I
Cytomap

6q21

7q21.3

Type of geneprotein-codingprotein-coding
Descriptionforkhead box protein O3forkhead box O3Aforkhead homolog (rhabdomyosarcoma) like 1forkhead in rhabdomyosarcoma-like 1forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1neurabin-1neural tissue-specific F-actin-binding protein Iprotein phosphatase 1, regulatory (inhibitor) subunit 9A
Modification date2020032920200313
UniProtAcc

O43524

.
Ensembl transtripts involved in fusion geneENST idsENST00000343882, ENST00000406360, 
ENST00000540898, 		ENST00000289495, 
ENST00000340694, ENST00000424654, 
ENST00000433360, ENST00000433881, 
ENST00000456331, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 5 X 7=3155 X 6 X 4=120
# samples 126
** MAII scorelog2(12/315*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: FOXO3 [Title/Abstract] AND PPP1R9A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FOXO3(108883032)-PPP1R9A(94876785), # samples:2
PPP1R9A(94855428)-FOXO3(108984658), # samples:2
Anticipated loss of major functional domain due to fusion event.FOXO3-PPP1R9A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FOXO3-PPP1R9A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FOXO3-PPP1R9A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FOXO3-PPP1R9A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP1R9A-FOXO3 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
PPP1R9A-FOXO3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
PPP1R9A-FOXO3 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
PPP1R9A-FOXO3 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFOXO3

GO:0000122

negative regulation of transcription by RNA polymerase II

20371612

HgeneFOXO3

GO:0006417

regulation of translation

21329882

HgeneFOXO3

GO:0043065

positive regulation of apoptotic process

20371612

HgeneFOXO3

GO:0045648

positive regulation of erythrocyte differentiation

14734530

HgeneFOXO3

GO:0045893

positive regulation of transcription, DNA-templated

10102273|15084260

HgeneFOXO3

GO:0045944

positive regulation of transcription by RNA polymerase II

10102273|14734530


check buttonFusion gene breakpoints across FOXO3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PPP1R9A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A0TS-01AFOXO3chr6

108883032

+PPP1R9Achr7

94876785

+
ChimerDB4BRCATCGA-AR-A0TSFOXO3chr6

108883032

+PPP1R9Achr7

94876784

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000343882FOXO3chr6108883032+ENST00000433360PPP1R9Achr794876785+39009252382937899
ENST00000343882FOXO3chr6108883032+ENST00000340694PPP1R9Achr794876785+82869252382175645
ENST00000343882FOXO3chr6108883032+ENST00000424654PPP1R9Achr794876785+26939252382640800
ENST00000343882FOXO3chr6108883032+ENST00000433881PPP1R9Achr794876785+82759252382175645
ENST00000343882FOXO3chr6108883032+ENST00000289495PPP1R9Achr794876785+88829252382769843
ENST00000343882FOXO3chr6108883032+ENST00000456331PPP1R9Achr794876785+87539252382640800
ENST00000406360FOXO3chr6108883032+ENST00000433360PPP1R9Achr794876785+39399642052976923
ENST00000406360FOXO3chr6108883032+ENST00000340694PPP1R9Achr794876785+83259642052214669
ENST00000406360FOXO3chr6108883032+ENST00000424654PPP1R9Achr794876785+27329642052679824
ENST00000406360FOXO3chr6108883032+ENST00000433881PPP1R9Achr794876785+83149642052214669
ENST00000406360FOXO3chr6108883032+ENST00000289495PPP1R9Achr794876785+89219642052808867
ENST00000406360FOXO3chr6108883032+ENST00000456331PPP1R9Achr794876785+87929642052679824
ENST00000343882FOXO3chr6108883032+ENST00000433360PPP1R9Achr794876784+39009252382937899
ENST00000343882FOXO3chr6108883032+ENST00000340694PPP1R9Achr794876784+82869252382175645
ENST00000343882FOXO3chr6108883032+ENST00000424654PPP1R9Achr794876784+26939252382640800
ENST00000343882FOXO3chr6108883032+ENST00000433881PPP1R9Achr794876784+82759252382175645
ENST00000343882FOXO3chr6108883032+ENST00000289495PPP1R9Achr794876784+88829252382769843
ENST00000343882FOXO3chr6108883032+ENST00000456331PPP1R9Achr794876784+87539252382640800
ENST00000406360FOXO3chr6108883032+ENST00000433360PPP1R9Achr794876784+39399642052976923
ENST00000406360FOXO3chr6108883032+ENST00000340694PPP1R9Achr794876784+83259642052214669
ENST00000406360FOXO3chr6108883032+ENST00000424654PPP1R9Achr794876784+27329642052679824
ENST00000406360FOXO3chr6108883032+ENST00000433881PPP1R9Achr794876784+83149642052214669
ENST00000406360FOXO3chr6108883032+ENST00000289495PPP1R9Achr794876784+89219642052808867
ENST00000406360FOXO3chr6108883032+ENST00000456331PPP1R9Achr794876784+87929642052679824

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000343882ENST00000433360FOXO3chr6108883032+PPP1R9Achr794876785+0.0016852590.99831474
ENST00000343882ENST00000340694FOXO3chr6108883032+PPP1R9Achr794876785+0.0002928720.99970704
ENST00000343882ENST00000424654FOXO3chr6108883032+PPP1R9Achr794876785+0.0069210.993079
ENST00000343882ENST00000433881FOXO3chr6108883032+PPP1R9Achr794876785+0.000294780.99970514
ENST00000343882ENST00000289495FOXO3chr6108883032+PPP1R9Achr794876785+0.0002474570.9997526
ENST00000343882ENST00000456331FOXO3chr6108883032+PPP1R9Achr794876785+0.0003169050.99968314
ENST00000406360ENST00000433360FOXO3chr6108883032+PPP1R9Achr794876785+0.001638340.99836165
ENST00000406360ENST00000340694FOXO3chr6108883032+PPP1R9Achr794876785+0.0002970850.9997029
ENST00000406360ENST00000424654FOXO3chr6108883032+PPP1R9Achr794876785+0.0068570.99314296
ENST00000406360ENST00000433881FOXO3chr6108883032+PPP1R9Achr794876785+0.0002987460.9997012
ENST00000406360ENST00000289495FOXO3chr6108883032+PPP1R9Achr794876785+0.0002530510.999747
ENST00000406360ENST00000456331FOXO3chr6108883032+PPP1R9Achr794876785+0.0003233180.9996767
ENST00000343882ENST00000433360FOXO3chr6108883032+PPP1R9Achr794876784+0.0016852590.99831474
ENST00000343882ENST00000340694FOXO3chr6108883032+PPP1R9Achr794876784+0.0002928720.99970704
ENST00000343882ENST00000424654FOXO3chr6108883032+PPP1R9Achr794876784+0.0069210.993079
ENST00000343882ENST00000433881FOXO3chr6108883032+PPP1R9Achr794876784+0.000294780.99970514
ENST00000343882ENST00000289495FOXO3chr6108883032+PPP1R9Achr794876784+0.0002474570.9997526
ENST00000343882ENST00000456331FOXO3chr6108883032+PPP1R9Achr794876784+0.0003169050.99968314
ENST00000406360ENST00000433360FOXO3chr6108883032+PPP1R9Achr794876784+0.001638340.99836165
ENST00000406360ENST00000340694FOXO3chr6108883032+PPP1R9Achr794876784+0.0002970850.9997029
ENST00000406360ENST00000424654FOXO3chr6108883032+PPP1R9Achr794876784+0.0068570.99314296
ENST00000406360ENST00000433881FOXO3chr6108883032+PPP1R9Achr794876784+0.0002987460.9997012
ENST00000406360ENST00000289495FOXO3chr6108883032+PPP1R9Achr794876784+0.0002530510.999747
ENST00000406360ENST00000456331FOXO3chr6108883032+PPP1R9Achr794876784+0.0003233180.9996767

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>31181_31181_1_FOXO3-PPP1R9A_FOXO3_chr6_108883032_ENST00000343882_PPP1R9A_chr7_94876784_ENST00000289495_length(amino acids)=843AA_BP=229
MHPAPAREESARAPAAGGRAAKMAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEEDDEDDED
GGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWG
NLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKLQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQLQQNIE
ENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDL
EAEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLDSKALKTRAQLSVKNRRQRPSRTRL
YDSVSSTDGEDSLERKGLRTSSPESDSGVPPLTPVDSNVPFSSDHIAEFQEEPLDPEMGPLSSMWGDTSLFSTSKSDHDVEESPCHHQTT
NKKILREKDDAKDPKSLRASSSLAVQGGKIKRKFVDLGAPLRRNSSKGKKWKEKEKEASRFSAGSRIFRGRLENWTPKPCSTAQTSTRSP
CMPFSWFNDSRKGSYSFRNLPAPTSSLQPSPETLISDKKGSKNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDEILDDGQSP
KHSQCQNRAVQEWSVQQVSHWLMSLNLEQYVSEFSAQNITGEQLLQLDGNKLKALGMTASQDRAVVKKKLKEMKMSLEKARKAQEKMEKQ

--------------------------------------------------------------

>31181_31181_2_FOXO3-PPP1R9A_FOXO3_chr6_108883032_ENST00000343882_PPP1R9A_chr7_94876784_ENST00000340694_length(amino acids)=645AA_BP=229
MHPAPAREESARAPAAGGRAAKMAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEEDDEDDED
GGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWG
NLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKLQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQLQQNIE
ENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDL
EAEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLDSKALKTRAQLSVKNRRQRPSRTRL
YDSVSSTDGEDSLERKNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDESLDMIDDEILDDGQSPKHSQCQNRAVQEWSVQQV
SHWLMSLNLEQYVSEFSAQNITGEQLLQLDGNKLKALGMTASQDRAVVKKKLKEMKMSLEKARKAQEKMEKQREKLRRKEQEQMQRKSKK

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>31181_31181_3_FOXO3-PPP1R9A_FOXO3_chr6_108883032_ENST00000343882_PPP1R9A_chr7_94876784_ENST00000424654_length(amino acids)=800AA_BP=229
MHPAPAREESARAPAAGGRAAKMAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEEDDEDDED
GGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWG
NLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKLQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQLQQNIE
ENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDL
EAEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLDSKALKTRAQLSVKNRRQRPSRTRL
YDSVSSTDGEDSLERKPSNSFYNHMHITKLLPPKGLRTSSPESDSGVPPLTPVDSNVPFSSDHIAEFQEEPLDPEMGPLSSMWGDTSLFS
TSKSDHDVEESPCHHQTTNKKILREKDDAKDPKSLRASSSLAVQGGKIKRKFVDLGAPLRRNSSKGKKWKEKEKEASRFSAGSRIFRGRL
ENWTPKPCSTAQTSTRSPCMPFSWFNDSRKGSYSFRNLPAPTSSLQPSPETLISDKKGSKNFTFNDDFSPSSTSSADLSGLGAEPKTPGL

--------------------------------------------------------------

>31181_31181_4_FOXO3-PPP1R9A_FOXO3_chr6_108883032_ENST00000343882_PPP1R9A_chr7_94876784_ENST00000433360_length(amino acids)=899AA_BP=229
MHPAPAREESARAPAAGGRAAKMAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEEDDEDDED
GGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWG
NLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKLQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQLQQNIE
ENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDL
EAEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLDSKALKTRAQLSVKNRRQRPSRTRL
YDSVSSTDGEDSLERKPSNSFYNHMHITKLLPPKGLRTSSPESDSGVPPLTPVDSNVPFSSDHIAEFQEEPLDPEMGPLSSMWGDTSLFS
TSKSDHDVEESPCHHQTTNKKILREKDDAKDPKSLRASSSLAVQGGKIKRKFVDLGAPLRRNSSKGKKWKEKEKEASRFSAGSRIFRGRL
ENWTPKPCSTAQTSTRSPCMPFSWFNDSRKGSYSFRNLPAPTSSLQPSPETLISDKKGSKVENTWITKANKRNPNPSSSSIFGRHSQLMS
VVWIQETNNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDEILDDGQSPKHSQCQNRAVQEWSVQQVSHWLMSLNLEQYVSEF

--------------------------------------------------------------

>31181_31181_5_FOXO3-PPP1R9A_FOXO3_chr6_108883032_ENST00000343882_PPP1R9A_chr7_94876784_ENST00000433881_length(amino acids)=645AA_BP=229
MHPAPAREESARAPAAGGRAAKMAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEEDDEDDED
GGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWG
NLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKLQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQLQQNIE
ENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDL
EAEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLDSKALKTRAQLSVKNRRQRPSRTRL
YDSVSSTDGEDSLERKNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDESLDMIDDEILDDGQSPKHSQCQNRAVQEWSVQQV
SHWLMSLNLEQYVSEFSAQNITGEQLLQLDGNKLKALGMTASQDRAVVKKKLKEMKMSLEKARKAQEKMEKQREKLRRKEQEQMQRKSKK

--------------------------------------------------------------

>31181_31181_6_FOXO3-PPP1R9A_FOXO3_chr6_108883032_ENST00000343882_PPP1R9A_chr7_94876784_ENST00000456331_length(amino acids)=800AA_BP=229
MHPAPAREESARAPAAGGRAAKMAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEEDDEDDED
GGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWG
NLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKLQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQLQQNIE
ENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDL
EAEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLDSKALKTRAQLSVKNRRQRPSRTRL
YDSVSSTDGEDSLERKPSNSFYNHMHITKLLPPKGLRTSSPESDSGVPPLTPVDSNVPFSSDHIAEFQEEPLDPEMGPLSSMWGDTSLFS
TSKSDHDVEESPCHHQTTNKKILREKDDAKDPKSLRASSSLAVQGGKIKRKFVDLGAPLRRNSSKGKKWKEKEKEASRFSAGSRIFRGRL
ENWTPKPCSTAQTSTRSPCMPFSWFNDSRKGSYSFRNLPAPTSSLQPSPETLISDKKGSKNFTFNDDFSPSSTSSADLSGLGAEPKTPGL

--------------------------------------------------------------

>31181_31181_7_FOXO3-PPP1R9A_FOXO3_chr6_108883032_ENST00000343882_PPP1R9A_chr7_94876785_ENST00000289495_length(amino acids)=843AA_BP=229
MHPAPAREESARAPAAGGRAAKMAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEEDDEDDED
GGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWG
NLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKLQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQLQQNIE
ENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDL
EAEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLDSKALKTRAQLSVKNRRQRPSRTRL
YDSVSSTDGEDSLERKGLRTSSPESDSGVPPLTPVDSNVPFSSDHIAEFQEEPLDPEMGPLSSMWGDTSLFSTSKSDHDVEESPCHHQTT
NKKILREKDDAKDPKSLRASSSLAVQGGKIKRKFVDLGAPLRRNSSKGKKWKEKEKEASRFSAGSRIFRGRLENWTPKPCSTAQTSTRSP
CMPFSWFNDSRKGSYSFRNLPAPTSSLQPSPETLISDKKGSKNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDEILDDGQSP
KHSQCQNRAVQEWSVQQVSHWLMSLNLEQYVSEFSAQNITGEQLLQLDGNKLKALGMTASQDRAVVKKKLKEMKMSLEKARKAQEKMEKQ

--------------------------------------------------------------

>31181_31181_8_FOXO3-PPP1R9A_FOXO3_chr6_108883032_ENST00000343882_PPP1R9A_chr7_94876785_ENST00000340694_length(amino acids)=645AA_BP=229
MHPAPAREESARAPAAGGRAAKMAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEEDDEDDED
GGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWG
NLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKLQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQLQQNIE
ENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDL
EAEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLDSKALKTRAQLSVKNRRQRPSRTRL
YDSVSSTDGEDSLERKNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDESLDMIDDEILDDGQSPKHSQCQNRAVQEWSVQQV
SHWLMSLNLEQYVSEFSAQNITGEQLLQLDGNKLKALGMTASQDRAVVKKKLKEMKMSLEKARKAQEKMEKQREKLRRKEQEQMQRKSKK

--------------------------------------------------------------

>31181_31181_9_FOXO3-PPP1R9A_FOXO3_chr6_108883032_ENST00000343882_PPP1R9A_chr7_94876785_ENST00000424654_length(amino acids)=800AA_BP=229
MHPAPAREESARAPAAGGRAAKMAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEEDDEDDED
GGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWG
NLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKLQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQLQQNIE
ENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDL
EAEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLDSKALKTRAQLSVKNRRQRPSRTRL
YDSVSSTDGEDSLERKPSNSFYNHMHITKLLPPKGLRTSSPESDSGVPPLTPVDSNVPFSSDHIAEFQEEPLDPEMGPLSSMWGDTSLFS
TSKSDHDVEESPCHHQTTNKKILREKDDAKDPKSLRASSSLAVQGGKIKRKFVDLGAPLRRNSSKGKKWKEKEKEASRFSAGSRIFRGRL
ENWTPKPCSTAQTSTRSPCMPFSWFNDSRKGSYSFRNLPAPTSSLQPSPETLISDKKGSKNFTFNDDFSPSSTSSADLSGLGAEPKTPGL

--------------------------------------------------------------

>31181_31181_10_FOXO3-PPP1R9A_FOXO3_chr6_108883032_ENST00000343882_PPP1R9A_chr7_94876785_ENST00000433360_length(amino acids)=899AA_BP=229
MHPAPAREESARAPAAGGRAAKMAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEEDDEDDED
GGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWG
NLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKLQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQLQQNIE
ENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDL
EAEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLDSKALKTRAQLSVKNRRQRPSRTRL
YDSVSSTDGEDSLERKPSNSFYNHMHITKLLPPKGLRTSSPESDSGVPPLTPVDSNVPFSSDHIAEFQEEPLDPEMGPLSSMWGDTSLFS
TSKSDHDVEESPCHHQTTNKKILREKDDAKDPKSLRASSSLAVQGGKIKRKFVDLGAPLRRNSSKGKKWKEKEKEASRFSAGSRIFRGRL
ENWTPKPCSTAQTSTRSPCMPFSWFNDSRKGSYSFRNLPAPTSSLQPSPETLISDKKGSKVENTWITKANKRNPNPSSSSIFGRHSQLMS
VVWIQETNNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDEILDDGQSPKHSQCQNRAVQEWSVQQVSHWLMSLNLEQYVSEF

--------------------------------------------------------------

>31181_31181_11_FOXO3-PPP1R9A_FOXO3_chr6_108883032_ENST00000343882_PPP1R9A_chr7_94876785_ENST00000433881_length(amino acids)=645AA_BP=229
MHPAPAREESARAPAAGGRAAKMAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEEDDEDDED
GGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWG
NLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKLQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQLQQNIE
ENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDL
EAEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLDSKALKTRAQLSVKNRRQRPSRTRL
YDSVSSTDGEDSLERKNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDESLDMIDDEILDDGQSPKHSQCQNRAVQEWSVQQV
SHWLMSLNLEQYVSEFSAQNITGEQLLQLDGNKLKALGMTASQDRAVVKKKLKEMKMSLEKARKAQEKMEKQREKLRRKEQEQMQRKSKK

--------------------------------------------------------------

>31181_31181_12_FOXO3-PPP1R9A_FOXO3_chr6_108883032_ENST00000343882_PPP1R9A_chr7_94876785_ENST00000456331_length(amino acids)=800AA_BP=229
MHPAPAREESARAPAAGGRAAKMAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEEDDEDDED
GGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWG
NLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKLQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQLQQNIE
ENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDL
EAEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLDSKALKTRAQLSVKNRRQRPSRTRL
YDSVSSTDGEDSLERKPSNSFYNHMHITKLLPPKGLRTSSPESDSGVPPLTPVDSNVPFSSDHIAEFQEEPLDPEMGPLSSMWGDTSLFS
TSKSDHDVEESPCHHQTTNKKILREKDDAKDPKSLRASSSLAVQGGKIKRKFVDLGAPLRRNSSKGKKWKEKEKEASRFSAGSRIFRGRL
ENWTPKPCSTAQTSTRSPCMPFSWFNDSRKGSYSFRNLPAPTSSLQPSPETLISDKKGSKNFTFNDDFSPSSTSSADLSGLGAEPKTPGL

--------------------------------------------------------------

>31181_31181_13_FOXO3-PPP1R9A_FOXO3_chr6_108883032_ENST00000406360_PPP1R9A_chr7_94876784_ENST00000289495_length(amino acids)=867AA_BP=253
MVLPQAAAAAPGSRSLRGVHVPPPLHPAPAREESARAPAAGGRAAKMAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASP
AKPSGETAADSMIPEEEDDEDDEDGGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLP
PPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKLQIKHAVTEAEIQKLKT
KLQAAENEKVRWELEKTQLQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAER
KKIEDLEKAHLVEVQGLQVRIRDLEAEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLD
SKALKTRAQLSVKNRRQRPSRTRLYDSVSSTDGEDSLERKGLRTSSPESDSGVPPLTPVDSNVPFSSDHIAEFQEEPLDPEMGPLSSMWG
DTSLFSTSKSDHDVEESPCHHQTTNKKILREKDDAKDPKSLRASSSLAVQGGKIKRKFVDLGAPLRRNSSKGKKWKEKEKEASRFSAGSR
IFRGRLENWTPKPCSTAQTSTRSPCMPFSWFNDSRKGSYSFRNLPAPTSSLQPSPETLISDKKGSKNFTFNDDFSPSSTSSADLSGLGAE
PKTPGLSQSLALSSDEILDDGQSPKHSQCQNRAVQEWSVQQVSHWLMSLNLEQYVSEFSAQNITGEQLLQLDGNKLKALGMTASQDRAVV

--------------------------------------------------------------

>31181_31181_14_FOXO3-PPP1R9A_FOXO3_chr6_108883032_ENST00000406360_PPP1R9A_chr7_94876784_ENST00000340694_length(amino acids)=669AA_BP=253
MVLPQAAAAAPGSRSLRGVHVPPPLHPAPAREESARAPAAGGRAAKMAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASP
AKPSGETAADSMIPEEEDDEDDEDGGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLP
PPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKLQIKHAVTEAEIQKLKT
KLQAAENEKVRWELEKTQLQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAER
KKIEDLEKAHLVEVQGLQVRIRDLEAEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLD
SKALKTRAQLSVKNRRQRPSRTRLYDSVSSTDGEDSLERKNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDESLDMIDDEIL
DDGQSPKHSQCQNRAVQEWSVQQVSHWLMSLNLEQYVSEFSAQNITGEQLLQLDGNKLKALGMTASQDRAVVKKKLKEMKMSLEKARKAQ

--------------------------------------------------------------

>31181_31181_15_FOXO3-PPP1R9A_FOXO3_chr6_108883032_ENST00000406360_PPP1R9A_chr7_94876784_ENST00000424654_length(amino acids)=824AA_BP=253
MVLPQAAAAAPGSRSLRGVHVPPPLHPAPAREESARAPAAGGRAAKMAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASP
AKPSGETAADSMIPEEEDDEDDEDGGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLP
PPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKLQIKHAVTEAEIQKLKT
KLQAAENEKVRWELEKTQLQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAER
KKIEDLEKAHLVEVQGLQVRIRDLEAEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLD
SKALKTRAQLSVKNRRQRPSRTRLYDSVSSTDGEDSLERKPSNSFYNHMHITKLLPPKGLRTSSPESDSGVPPLTPVDSNVPFSSDHIAE
FQEEPLDPEMGPLSSMWGDTSLFSTSKSDHDVEESPCHHQTTNKKILREKDDAKDPKSLRASSSLAVQGGKIKRKFVDLGAPLRRNSSKG
KKWKEKEKEASRFSAGSRIFRGRLENWTPKPCSTAQTSTRSPCMPFSWFNDSRKGSYSFRNLPAPTSSLQPSPETLISDKKGSKNFTFND
DFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDEALGMTASQDRAVVKKKLKEMKMSLEKARKAQEKMEKQREKLRRKEQEQMQRKSKKT

--------------------------------------------------------------

>31181_31181_16_FOXO3-PPP1R9A_FOXO3_chr6_108883032_ENST00000406360_PPP1R9A_chr7_94876784_ENST00000433360_length(amino acids)=923AA_BP=253
MVLPQAAAAAPGSRSLRGVHVPPPLHPAPAREESARAPAAGGRAAKMAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASP
AKPSGETAADSMIPEEEDDEDDEDGGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLP
PPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKLQIKHAVTEAEIQKLKT
KLQAAENEKVRWELEKTQLQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAER
KKIEDLEKAHLVEVQGLQVRIRDLEAEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLD
SKALKTRAQLSVKNRRQRPSRTRLYDSVSSTDGEDSLERKPSNSFYNHMHITKLLPPKGLRTSSPESDSGVPPLTPVDSNVPFSSDHIAE
FQEEPLDPEMGPLSSMWGDTSLFSTSKSDHDVEESPCHHQTTNKKILREKDDAKDPKSLRASSSLAVQGGKIKRKFVDLGAPLRRNSSKG
KKWKEKEKEASRFSAGSRIFRGRLENWTPKPCSTAQTSTRSPCMPFSWFNDSRKGSYSFRNLPAPTSSLQPSPETLISDKKGSKVENTWI
TKANKRNPNPSSSSIFGRHSQLMSVVWIQETNNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDEILDDGQSPKHSQCQNRAV
QEWSVQQVSHWLMSLNLEQYVSEFSAQNITGEQLLQLDGNKLKALGMTASQDRAVVKKKLKEMKMSLEKARKAQEKMEKQREKLRRKEQE

--------------------------------------------------------------

>31181_31181_17_FOXO3-PPP1R9A_FOXO3_chr6_108883032_ENST00000406360_PPP1R9A_chr7_94876784_ENST00000433881_length(amino acids)=669AA_BP=253
MVLPQAAAAAPGSRSLRGVHVPPPLHPAPAREESARAPAAGGRAAKMAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASP
AKPSGETAADSMIPEEEDDEDDEDGGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLP
PPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKLQIKHAVTEAEIQKLKT
KLQAAENEKVRWELEKTQLQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAER
KKIEDLEKAHLVEVQGLQVRIRDLEAEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLD
SKALKTRAQLSVKNRRQRPSRTRLYDSVSSTDGEDSLERKNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDESLDMIDDEIL
DDGQSPKHSQCQNRAVQEWSVQQVSHWLMSLNLEQYVSEFSAQNITGEQLLQLDGNKLKALGMTASQDRAVVKKKLKEMKMSLEKARKAQ

--------------------------------------------------------------

>31181_31181_18_FOXO3-PPP1R9A_FOXO3_chr6_108883032_ENST00000406360_PPP1R9A_chr7_94876784_ENST00000456331_length(amino acids)=824AA_BP=253
MVLPQAAAAAPGSRSLRGVHVPPPLHPAPAREESARAPAAGGRAAKMAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASP
AKPSGETAADSMIPEEEDDEDDEDGGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLP
PPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKLQIKHAVTEAEIQKLKT
KLQAAENEKVRWELEKTQLQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAER
KKIEDLEKAHLVEVQGLQVRIRDLEAEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLD
SKALKTRAQLSVKNRRQRPSRTRLYDSVSSTDGEDSLERKPSNSFYNHMHITKLLPPKGLRTSSPESDSGVPPLTPVDSNVPFSSDHIAE
FQEEPLDPEMGPLSSMWGDTSLFSTSKSDHDVEESPCHHQTTNKKILREKDDAKDPKSLRASSSLAVQGGKIKRKFVDLGAPLRRNSSKG
KKWKEKEKEASRFSAGSRIFRGRLENWTPKPCSTAQTSTRSPCMPFSWFNDSRKGSYSFRNLPAPTSSLQPSPETLISDKKGSKNFTFND
DFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDEALGMTASQDRAVVKKKLKEMKMSLEKARKAQEKMEKQREKLRRKEQEQMQRKSKKT

--------------------------------------------------------------

>31181_31181_19_FOXO3-PPP1R9A_FOXO3_chr6_108883032_ENST00000406360_PPP1R9A_chr7_94876785_ENST00000289495_length(amino acids)=867AA_BP=253
MVLPQAAAAAPGSRSLRGVHVPPPLHPAPAREESARAPAAGGRAAKMAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASP
AKPSGETAADSMIPEEEDDEDDEDGGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLP
PPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKLQIKHAVTEAEIQKLKT
KLQAAENEKVRWELEKTQLQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAER
KKIEDLEKAHLVEVQGLQVRIRDLEAEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLD
SKALKTRAQLSVKNRRQRPSRTRLYDSVSSTDGEDSLERKGLRTSSPESDSGVPPLTPVDSNVPFSSDHIAEFQEEPLDPEMGPLSSMWG
DTSLFSTSKSDHDVEESPCHHQTTNKKILREKDDAKDPKSLRASSSLAVQGGKIKRKFVDLGAPLRRNSSKGKKWKEKEKEASRFSAGSR
IFRGRLENWTPKPCSTAQTSTRSPCMPFSWFNDSRKGSYSFRNLPAPTSSLQPSPETLISDKKGSKNFTFNDDFSPSSTSSADLSGLGAE
PKTPGLSQSLALSSDEILDDGQSPKHSQCQNRAVQEWSVQQVSHWLMSLNLEQYVSEFSAQNITGEQLLQLDGNKLKALGMTASQDRAVV

--------------------------------------------------------------

>31181_31181_20_FOXO3-PPP1R9A_FOXO3_chr6_108883032_ENST00000406360_PPP1R9A_chr7_94876785_ENST00000340694_length(amino acids)=669AA_BP=253
MVLPQAAAAAPGSRSLRGVHVPPPLHPAPAREESARAPAAGGRAAKMAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASP
AKPSGETAADSMIPEEEDDEDDEDGGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLP
PPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKLQIKHAVTEAEIQKLKT
KLQAAENEKVRWELEKTQLQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAER
KKIEDLEKAHLVEVQGLQVRIRDLEAEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLD
SKALKTRAQLSVKNRRQRPSRTRLYDSVSSTDGEDSLERKNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDESLDMIDDEIL
DDGQSPKHSQCQNRAVQEWSVQQVSHWLMSLNLEQYVSEFSAQNITGEQLLQLDGNKLKALGMTASQDRAVVKKKLKEMKMSLEKARKAQ

--------------------------------------------------------------

>31181_31181_21_FOXO3-PPP1R9A_FOXO3_chr6_108883032_ENST00000406360_PPP1R9A_chr7_94876785_ENST00000424654_length(amino acids)=824AA_BP=253
MVLPQAAAAAPGSRSLRGVHVPPPLHPAPAREESARAPAAGGRAAKMAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASP
AKPSGETAADSMIPEEEDDEDDEDGGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLP
PPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKLQIKHAVTEAEIQKLKT
KLQAAENEKVRWELEKTQLQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAER
KKIEDLEKAHLVEVQGLQVRIRDLEAEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLD
SKALKTRAQLSVKNRRQRPSRTRLYDSVSSTDGEDSLERKPSNSFYNHMHITKLLPPKGLRTSSPESDSGVPPLTPVDSNVPFSSDHIAE
FQEEPLDPEMGPLSSMWGDTSLFSTSKSDHDVEESPCHHQTTNKKILREKDDAKDPKSLRASSSLAVQGGKIKRKFVDLGAPLRRNSSKG
KKWKEKEKEASRFSAGSRIFRGRLENWTPKPCSTAQTSTRSPCMPFSWFNDSRKGSYSFRNLPAPTSSLQPSPETLISDKKGSKNFTFND
DFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDEALGMTASQDRAVVKKKLKEMKMSLEKARKAQEKMEKQREKLRRKEQEQMQRKSKKT

--------------------------------------------------------------

>31181_31181_22_FOXO3-PPP1R9A_FOXO3_chr6_108883032_ENST00000406360_PPP1R9A_chr7_94876785_ENST00000433360_length(amino acids)=923AA_BP=253
MVLPQAAAAAPGSRSLRGVHVPPPLHPAPAREESARAPAAGGRAAKMAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASP
AKPSGETAADSMIPEEEDDEDDEDGGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLP
PPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKLQIKHAVTEAEIQKLKT
KLQAAENEKVRWELEKTQLQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAER
KKIEDLEKAHLVEVQGLQVRIRDLEAEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLD
SKALKTRAQLSVKNRRQRPSRTRLYDSVSSTDGEDSLERKPSNSFYNHMHITKLLPPKGLRTSSPESDSGVPPLTPVDSNVPFSSDHIAE
FQEEPLDPEMGPLSSMWGDTSLFSTSKSDHDVEESPCHHQTTNKKILREKDDAKDPKSLRASSSLAVQGGKIKRKFVDLGAPLRRNSSKG
KKWKEKEKEASRFSAGSRIFRGRLENWTPKPCSTAQTSTRSPCMPFSWFNDSRKGSYSFRNLPAPTSSLQPSPETLISDKKGSKVENTWI
TKANKRNPNPSSSSIFGRHSQLMSVVWIQETNNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDEILDDGQSPKHSQCQNRAV
QEWSVQQVSHWLMSLNLEQYVSEFSAQNITGEQLLQLDGNKLKALGMTASQDRAVVKKKLKEMKMSLEKARKAQEKMEKQREKLRRKEQE

--------------------------------------------------------------

>31181_31181_23_FOXO3-PPP1R9A_FOXO3_chr6_108883032_ENST00000406360_PPP1R9A_chr7_94876785_ENST00000433881_length(amino acids)=669AA_BP=253
MVLPQAAAAAPGSRSLRGVHVPPPLHPAPAREESARAPAAGGRAAKMAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASP
AKPSGETAADSMIPEEEDDEDDEDGGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLP
PPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKLQIKHAVTEAEIQKLKT
KLQAAENEKVRWELEKTQLQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAER
KKIEDLEKAHLVEVQGLQVRIRDLEAEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLD
SKALKTRAQLSVKNRRQRPSRTRLYDSVSSTDGEDSLERKNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDESLDMIDDEIL
DDGQSPKHSQCQNRAVQEWSVQQVSHWLMSLNLEQYVSEFSAQNITGEQLLQLDGNKLKALGMTASQDRAVVKKKLKEMKMSLEKARKAQ

--------------------------------------------------------------

>31181_31181_24_FOXO3-PPP1R9A_FOXO3_chr6_108883032_ENST00000406360_PPP1R9A_chr7_94876785_ENST00000456331_length(amino acids)=824AA_BP=253
MVLPQAAAAAPGSRSLRGVHVPPPLHPAPAREESARAPAAGGRAAKMAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASP
AKPSGETAADSMIPEEEDDEDDEDGGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLP
PPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKLQIKHAVTEAEIQKLKT
KLQAAENEKVRWELEKTQLQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAER
KKIEDLEKAHLVEVQGLQVRIRDLEAEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLD
SKALKTRAQLSVKNRRQRPSRTRLYDSVSSTDGEDSLERKPSNSFYNHMHITKLLPPKGLRTSSPESDSGVPPLTPVDSNVPFSSDHIAE
FQEEPLDPEMGPLSSMWGDTSLFSTSKSDHDVEESPCHHQTTNKKILREKDDAKDPKSLRASSSLAVQGGKIKRKFVDLGAPLRRNSSKG
KKWKEKEKEASRFSAGSRIFRGRLENWTPKPCSTAQTSTRSPCMPFSWFNDSRKGSYSFRNLPAPTSSLQPSPETLISDKKGSKNFTFND
DFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDEALGMTASQDRAVVKKKLKEMKMSLEKARKAQEKMEKQREKLRRKEQEQMQRKSKKT

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:108883032/chr7:94876785)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FOXO3

O43524

.
FUNCTION: Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). {ECO:0000250|UniProtKB:Q9WVH4, ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:23283301}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePPP1R9Achr6:108883032chr7:94876784ENST000003406946161033_1090682.01099.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R9Achr6:108883032chr7:94876784ENST000004246546181033_1090682.01254.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R9Achr6:108883032chr7:94876784ENST000004333607201033_1090704.01375.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R9Achr6:108883032chr7:94876784ENST000004338816161033_1090682.01099.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R9Achr6:108883032chr7:94876784ENST000004563315171033_1090682.01254.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R9Achr6:108883032chr7:94876785ENST000003406946161033_1090682.01099.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R9Achr6:108883032chr7:94876785ENST000004246546181033_1090682.01254.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R9Achr6:108883032chr7:94876785ENST000004333607201033_1090704.01375.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R9Achr6:108883032chr7:94876785ENST000004338816161033_1090682.01099.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R9Achr6:108883032chr7:94876785ENST000004563315171033_1090682.01254.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000340694616829_833682.01099.0Compositional biasNote=Poly-Asn
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000424654618829_833682.01254.0Compositional biasNote=Poly-Asn
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000433360720829_833704.01375.0Compositional biasNote=Poly-Asn
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000433881616829_833682.01099.0Compositional biasNote=Poly-Asn
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000456331517829_833682.01254.0Compositional biasNote=Poly-Asn
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000340694616829_833682.01099.0Compositional biasNote=Poly-Asn
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000424654618829_833682.01254.0Compositional biasNote=Poly-Asn
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000433360720829_833704.01375.0Compositional biasNote=Poly-Asn
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000433881616829_833682.01099.0Compositional biasNote=Poly-Asn
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000456331517829_833682.01254.0Compositional biasNote=Poly-Asn
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000340694616988_1051682.01099.0DomainSAM
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000424654618988_1051682.01254.0DomainSAM
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000433360720988_1051704.01375.0DomainSAM
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000433881616988_1051682.01099.0DomainSAM
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000456331517988_1051682.01254.0DomainSAM
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000340694616988_1051682.01099.0DomainSAM
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000424654618988_1051682.01254.0DomainSAM
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000433360720988_1051704.01375.0DomainSAM
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000433881616988_1051682.01099.0DomainSAM
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000456331517988_1051682.01254.0DomainSAM

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFOXO3chr6:108883032chr7:94876784ENST00000343882+24157_251207.02263.0DNA bindingFork-head
HgeneFOXO3chr6:108883032chr7:94876784ENST00000406360+13157_251207.02000.0DNA bindingFork-head
HgeneFOXO3chr6:108883032chr7:94876785ENST00000343882+24157_251207.02263.0DNA bindingFork-head
HgeneFOXO3chr6:108883032chr7:94876785ENST00000406360+13157_251207.02000.0DNA bindingFork-head
HgeneFOXO3chr6:108883032chr7:94876784ENST00000343882+24242_259207.02263.0MotifNuclear localization signal
HgeneFOXO3chr6:108883032chr7:94876784ENST00000406360+13242_259207.02000.0MotifNuclear localization signal
HgeneFOXO3chr6:108883032chr7:94876785ENST00000343882+24242_259207.02263.0MotifNuclear localization signal
HgeneFOXO3chr6:108883032chr7:94876785ENST00000406360+13242_259207.02000.0MotifNuclear localization signal
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000340694616597_627682.01099.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000340694616670_824682.01099.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000424654618597_627682.01254.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000424654618670_824682.01254.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000433360720597_627704.01375.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000433360720670_824704.01375.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000433881616597_627682.01099.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000433881616670_824682.01099.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000456331517597_627682.01254.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000456331517670_824682.01254.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000340694616597_627682.01099.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000340694616670_824682.01099.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000424654618597_627682.01254.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000424654618670_824682.01254.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000433360720597_627704.01375.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000433360720670_824704.01375.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000433881616597_627682.01099.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000433881616670_824682.01099.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000456331517597_627682.01254.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000456331517670_824682.01254.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000340694616447_450682.01099.0Compositional biasNote=Poly-Glu
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000424654618447_450682.01254.0Compositional biasNote=Poly-Glu
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000433360720447_450704.01375.0Compositional biasNote=Poly-Glu
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000433881616447_450682.01099.0Compositional biasNote=Poly-Glu
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000456331517447_450682.01254.0Compositional biasNote=Poly-Glu
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000340694616447_450682.01099.0Compositional biasNote=Poly-Glu
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000424654618447_450682.01254.0Compositional biasNote=Poly-Glu
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000433360720447_450704.01375.0Compositional biasNote=Poly-Glu
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000433881616447_450682.01099.0Compositional biasNote=Poly-Glu
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000456331517447_450682.01254.0Compositional biasNote=Poly-Glu
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000340694616504_592682.01099.0DomainPDZ
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000424654618504_592682.01254.0DomainPDZ
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000433360720504_592704.01375.0DomainPDZ
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000433881616504_592682.01099.0DomainPDZ
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000456331517504_592682.01254.0DomainPDZ
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000340694616504_592682.01099.0DomainPDZ
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000424654618504_592682.01254.0DomainPDZ
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000433360720504_592704.01375.0DomainPDZ
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000433881616504_592682.01099.0DomainPDZ
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000456331517504_592682.01254.0DomainPDZ
TgenePPP1R9Achr6:108883032chr7:94876784ENST000003406946161_144682.01099.0RegionNote=Actin-binding
TgenePPP1R9Achr6:108883032chr7:94876784ENST000004246546181_144682.01254.0RegionNote=Actin-binding
TgenePPP1R9Achr6:108883032chr7:94876784ENST000004333607201_144704.01375.0RegionNote=Actin-binding
TgenePPP1R9Achr6:108883032chr7:94876784ENST000004338816161_144682.01099.0RegionNote=Actin-binding
TgenePPP1R9Achr6:108883032chr7:94876784ENST000004563315171_144682.01254.0RegionNote=Actin-binding
TgenePPP1R9Achr6:108883032chr7:94876785ENST000003406946161_144682.01099.0RegionNote=Actin-binding
TgenePPP1R9Achr6:108883032chr7:94876785ENST000004246546181_144682.01254.0RegionNote=Actin-binding
TgenePPP1R9Achr6:108883032chr7:94876785ENST000004333607201_144704.01375.0RegionNote=Actin-binding
TgenePPP1R9Achr6:108883032chr7:94876785ENST000004338816161_144682.01099.0RegionNote=Actin-binding
TgenePPP1R9Achr6:108883032chr7:94876785ENST000004563315171_144682.01254.0RegionNote=Actin-binding


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
FOXO3
PPP1R9A


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000340694616425_502682.01099.0protein phosphatase 1
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000424654618425_502682.01254.0protein phosphatase 1
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000433360720425_502704.01375.0protein phosphatase 1
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000433881616425_502682.01099.0protein phosphatase 1
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000456331517425_502682.01254.0protein phosphatase 1
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000340694616425_502682.01099.0protein phosphatase 1
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000424654618425_502682.01254.0protein phosphatase 1
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000433360720425_502704.01375.0protein phosphatase 1
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000433881616425_502682.01099.0protein phosphatase 1
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000456331517425_502682.01254.0protein phosphatase 1
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000340694616597_1090682.01099.0TGN38
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000424654618597_1090682.01254.0TGN38
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000433360720597_1090704.01375.0TGN38
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000433881616597_1090682.01099.0TGN38
TgenePPP1R9Achr6:108883032chr7:94876784ENST00000456331517597_1090682.01254.0TGN38
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000340694616597_1090682.01099.0TGN38
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000424654618597_1090682.01254.0TGN38
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000433360720597_1090704.01375.0TGN38
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000433881616597_1090682.01099.0TGN38
TgenePPP1R9Achr6:108883032chr7:94876785ENST00000456331517597_1090682.01254.0TGN38


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Related Drugs to FOXO3-PPP1R9A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to FOXO3-PPP1R9A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource