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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:FUS-CREB3L2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: FUS-CREB3L2
FusionPDB ID: 31795
FusionGDB2.0 ID: 31795
HgeneTgene
Gene symbol

FUS

CREB3L2

Gene ID

2521

64764

Gene nameFUS RNA binding proteincAMP responsive element binding protein 3 like 2
SynonymsALS6|ETM4|FUS1|HNRNPP2|POMP75|TLSBBF2H7
Cytomap

16p11.2

7q33

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein FUS75 kDa DNA-pairing proteinfus-like proteinfused in sarcomafusion gene in myxoid liposarcomaheterogeneous nuclear ribonucleoprotein P2oncogene FUSoncogene TLStranslocated in liposarcoma proteincyclic AMP-responsive element-binding protein 3-like protein 2B-ZIB transcription factorBBF2 human homolog on chromosome 7FUS/BBF2H7 proteinTCAG_1951439basic transcription factor 2cAMP-responsive element-binding protein 3-like protein 2
Modification date2020032920200313
UniProtAcc

P35637

Q70SY1

Ensembl transtripts involved in fusion geneENST idsENST00000254108, ENST00000380244, 
ENST00000568685, ENST00000474990, 
ENST00000330387, ENST00000452463, 
ENST00000456390, ENST00000458726, 
ENST00000468127, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score37 X 37 X 16=219045 X 10 X 5=250
# samples 449
** MAII scorelog2(44/21904*10)=-5.63754701773324
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/250*10)=-1.47393118833241
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: FUS [Title/Abstract] AND CREB3L2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CREB3L2(137686349)-FUS(31199645), # samples:2
FUS(31199514)-CREB3L2(137565145), # samples:1
FUS(31199478)-CREB3L2(137593090), # samples:1
FUS(31196384)-CREB3L2(137593099), # samples:1
FUS(31196358)-CREB3L2(137664456), # samples:1
Anticipated loss of major functional domain due to fusion event.CREB3L2-FUS seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
CREB3L2-FUS seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CREB3L2-FUS seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
CREB3L2-FUS seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
CREB3L2-FUS seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
CREB3L2-FUS seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
FUS-CREB3L2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
FUS-CREB3L2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FUS-CREB3L2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
FUS-CREB3L2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
FUS-CREB3L2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
FUS-CREB3L2 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFUS

GO:0006355

regulation of transcription, DNA-templated

26124092

HgeneFUS

GO:0006357

regulation of transcription by RNA polymerase II

25453086

HgeneFUS

GO:0008380

RNA splicing

26124092

HgeneFUS

GO:0043484

regulation of RNA splicing

25453086|27731383

HgeneFUS

GO:0048255

mRNA stabilization

27378374

HgeneFUS

GO:0051260

protein homooligomerization

25453086

HgeneFUS

GO:1905168

positive regulation of double-strand break repair via homologous recombination

10567410

TgeneCREB3L2

GO:0045893

positive regulation of transcription, DNA-templated

17178827


check buttonFusion gene breakpoints across FUS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CREB3L2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4fibromyxoid sarcomaAJ549093FUSchr16

31199514

CREB3L2chr7

137565145
ChimerKB3..FUSchr16

31195705

+CREB3L2chr7

137590594

-
ChimerKB3..FUSchr16

31195705

+CREB3L2chr7

137593182

-
ChimerKB3..FUSchr16

31196384

+CREB3L2chr7

137565145

-
ChimerKB3..FUSchr16

31196500

+CREB3L2chr

137593182

-
ChimerKB3..FUSchr16

31196500

+CREB3L2chr7

137593182

-
ChimerKB3..FUSchr16

31199514

+CREB3L2chr7

137565145

-
ChimerKB4..FUSchr16

31195705

+CREB3L2chr7

137593182

-
ChimerKB4..FUSchr16

31196500

+CREB3L2chr7

137593182

-
ChiTaRS5.0N/AAJ549093FUSchr16

31199478

-CREB3L2chr7

137593090

-
ChiTaRS5.0N/AAJ549094FUSchr16

31196384

+CREB3L2chr7

137593099

-
ChiTaRS5.0N/AAJ549097FUSchr16

31196358

+CREB3L2chr7

137664456

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000254108FUSchr1631195705+ENST00000330387CREB3L2chr7137593182-6929452731431452
ENST00000254108FUSchr1631195705+ENST00000456390CREB3L2chr7137593182-1867452731251392
ENST00000380244FUSchr1631195705+ENST00000330387CREB3L2chr7137593182-6897420441399451
ENST00000380244FUSchr1631195705+ENST00000456390CREB3L2chr7137593182-1835420441219391
ENST00000568685FUSchr1631195705+ENST00000330387CREB3L2chr7137593182-6888411321390452
ENST00000568685FUSchr1631195705+ENST00000456390CREB3L2chr7137593182-1826411321210392

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>31795_31795_1_FUS-CREB3L2_FUS_chr16_31195705_ENST00000254108_CREB3L2_chr7_137593182_ENST00000330387_length(amino acids)=452AA_BP=126
MLACLCARARTWPQTIIPNKQPKAMGPTPPSPGRAIPSRAVSPTDSRVTVVIASPRTLQAMARAAILLMARARTQAMELSQLPRDMARLA
AMAVARAPNRLTGSSPPTLAMASSQLPAAPREGGGGAPVDHLHLPPTPPSSHGSDSEGSLSPNPRLHPFSLPQTHSPSRAAPRAPSALSS
SPLLTAPHKLQGSGPLVLTEEEKRTLIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRK
KVEVLENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQHSLQEPYTASVVRSRN
LLIYEEHSPPEESSSPGSAGELGGWDRGSSLLRVSGLESRPDVDLPHFIISNETSLEKSVLLELQQHLVSAKLEGNETLKVVELDRRVNT

--------------------------------------------------------------

>31795_31795_2_FUS-CREB3L2_FUS_chr16_31195705_ENST00000254108_CREB3L2_chr7_137593182_ENST00000456390_length(amino acids)=392AA_BP=126
MLACLCARARTWPQTIIPNKQPKAMGPTPPSPGRAIPSRAVSPTDSRVTVVIASPRTLQAMARAAILLMARARTQAMELSQLPRDMARLA
AMAVARAPNRLTGSSPPTLAMASSQLPAAPREGGGGAPVDHLHLPPTPPSSHGSDSEGSLSPNPRLHPFSLPQTHSPSRAAPRAPSALSS
SPLLTAPHKLQGSGPLVLTEEEKRTLIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRK
KVEVLENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQHSLQEPYTASVGKTAC

--------------------------------------------------------------

>31795_31795_3_FUS-CREB3L2_FUS_chr16_31195705_ENST00000380244_CREB3L2_chr7_137593182_ENST00000330387_length(amino acids)=451AA_BP=125
MLACLCARARTWPQTIIPNKQPKAMGPTPPSPGRAIPSRAVSPTDSRVTVVIASPRTLQAMARAAILLMARARTAMELSQLPRDMARLAA
MAVARAPNRLTGSSPPTLAMASSQLPAAPREGGGGAPVDHLHLPPTPPSSHGSDSEGSLSPNPRLHPFSLPQTHSPSRAAPRAPSALSSS
PLLTAPHKLQGSGPLVLTEEEKRTLIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRKK
VEVLENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQHSLQEPYTASVVRSRNL
LIYEEHSPPEESSSPGSAGELGGWDRGSSLLRVSGLESRPDVDLPHFIISNETSLEKSVLLELQQHLVSAKLEGNETLKVVELDRRVNTT

--------------------------------------------------------------

>31795_31795_4_FUS-CREB3L2_FUS_chr16_31195705_ENST00000380244_CREB3L2_chr7_137593182_ENST00000456390_length(amino acids)=391AA_BP=125
MLACLCARARTWPQTIIPNKQPKAMGPTPPSPGRAIPSRAVSPTDSRVTVVIASPRTLQAMARAAILLMARARTAMELSQLPRDMARLAA
MAVARAPNRLTGSSPPTLAMASSQLPAAPREGGGGAPVDHLHLPPTPPSSHGSDSEGSLSPNPRLHPFSLPQTHSPSRAAPRAPSALSSS
PLLTAPHKLQGSGPLVLTEEEKRTLIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRKK
VEVLENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQHSLQEPYTASVGKTACG

--------------------------------------------------------------

>31795_31795_5_FUS-CREB3L2_FUS_chr16_31195705_ENST00000568685_CREB3L2_chr7_137593182_ENST00000330387_length(amino acids)=452AA_BP=126
MLACLCARARTWPQTIIPNKQPKAMGPTPPSPGRAIPSRAVSPTDSRVTVVIASPRTLQAMARAAILLMARARTQAMELSQLPRDMARLA
AMAVARAPNRLTGSSPPTLAMASSQLPAAPREGGGGAPVDHLHLPPTPPSSHGSDSEGSLSPNPRLHPFSLPQTHSPSRAAPRAPSALSS
SPLLTAPHKLQGSGPLVLTEEEKRTLIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRK
KVEVLENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQHSLQEPYTASVVRSRN
LLIYEEHSPPEESSSPGSAGELGGWDRGSSLLRVSGLESRPDVDLPHFIISNETSLEKSVLLELQQHLVSAKLEGNETLKVVELDRRVNT

--------------------------------------------------------------

>31795_31795_6_FUS-CREB3L2_FUS_chr16_31195705_ENST00000568685_CREB3L2_chr7_137593182_ENST00000456390_length(amino acids)=392AA_BP=126
MLACLCARARTWPQTIIPNKQPKAMGPTPPSPGRAIPSRAVSPTDSRVTVVIASPRTLQAMARAAILLMARARTQAMELSQLPRDMARLA
AMAVARAPNRLTGSSPPTLAMASSQLPAAPREGGGGAPVDHLHLPPTPPSSHGSDSEGSLSPNPRLHPFSLPQTHSPSRAAPRAPSALSS
SPLLTAPHKLQGSGPLVLTEEEKRTLIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRK
KVEVLENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQHSLQEPYTASVGKTAC

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:137686349/chr7:31199645)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FUS

P35637

CREB3L2

Q70SY1

FUNCTION: DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}.FUNCTION: Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site (PubMed:17178827). {ECO:0000250|UniProtKB:Q8BH52, ECO:0000269|PubMed:17178827}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (145) >>>145.pdbFusion protein BP residue: 125
CIF file (145) >>>145.cif		FUSchr1631195705+CREB3L2chr7137593182-
MLACLCARARTWPQTIIPNKQPKAMGPTPPSPGRAIPSRAVSPTDSRVTV
VIASPRTLQAMARAAILLMARARTAMELSQLPRDMARLAAMAVARAPNRL
TGSSPPTLAMASSQLPAAPREGGGGAPVDHLHLPPTPPSSHGSDSEGSLS
PNPRLHPFSLPQTHSPSRAAPRAPSALSSSPLLTAPHKLQGSGPLVLTEE
EKRTLIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYM
DSLEKKVESCSTENLELRKKVEVLENTNRTLLQQLQKLQTLVMGKVSRTC
KLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQHSLQEPY
391
3D view using mol* of 145 (AA BP:125)
PDB file (147)FUSchr1631195705+CREB3L2chr7137593182-
MLACLCARARTWPQTIIPNKQPKAMGPTPPSPGRAIPSRAVSPTDSRVTV
VIASPRTLQAMARAAILLMARARTQAMELSQLPRDMARLAAMAVARAPNR
LTGSSPPTLAMASSQLPAAPREGGGGAPVDHLHLPPTPPSSHGSDSEGSL
SPNPRLHPFSLPQTHSPSRAAPRAPSALSSSPLLTAPHKLQGSGPLVLTE
EEKRTLIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEY
MDSLEKKVESCSTENLELRKKVEVLENTNRTLLQQLQKLQTLVMGKVSRT
CKLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQHSLQEP
392
PDB file (220) >>>220.pdbFusion protein BP residue: 125
CIF file (220) >>>220.cif		FUSchr1631195705+CREB3L2chr7137593182-
MLACLCARARTWPQTIIPNKQPKAMGPTPPSPGRAIPSRAVSPTDSRVTV
VIASPRTLQAMARAAILLMARARTAMELSQLPRDMARLAAMAVARAPNRL
TGSSPPTLAMASSQLPAAPREGGGGAPVDHLHLPPTPPSSHGSDSEGSLS
PNPRLHPFSLPQTHSPSRAAPRAPSALSSSPLLTAPHKLQGSGPLVLTEE
EKRTLIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYM
DSLEKKVESCSTENLELRKKVEVLENTNRTLLQQLQKLQTLVMGKVSRTC
KLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQHSLQEPY
TASVVRSRNLLIYEEHSPPEESSSPGSAGELGGWDRGSSLLRVSGLESRP
DVDLPHFIISNETSLEKSVLLELQQHLVSAKLEGNETLKVVELDRRVNTT
451
3D view using mol* of 220 (AA BP:125)
PDB file (221) >>>221.pdbFusion protein BP residue: 126
CIF file (221) >>>221.cif		FUSchr1631195705+CREB3L2chr7137593182-
MLACLCARARTWPQTIIPNKQPKAMGPTPPSPGRAIPSRAVSPTDSRVTV
VIASPRTLQAMARAAILLMARARTQAMELSQLPRDMARLAAMAVARAPNR
LTGSSPPTLAMASSQLPAAPREGGGGAPVDHLHLPPTPPSSHGSDSEGSL
SPNPRLHPFSLPQTHSPSRAAPRAPSALSSSPLLTAPHKLQGSGPLVLTE
EEKRTLIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEY
MDSLEKKVESCSTENLELRKKVEVLENTNRTLLQQLQKLQTLVMGKVSRT
CKLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQHSLQEP
YTASVVRSRNLLIYEEHSPPEESSSPGSAGELGGWDRGSSLLRVSGLESR
PDVDLPHFIISNETSLEKSVLLELQQHLVSAKLEGNETLKVVELDRRVNT
452
3D view using mol* of 221 (AA BP:126)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
FUS_pLDDT.png
all structure
all structure

all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
FUS_CREB3L2_145_PAE.png (AA BP:125)
all structure
FUS_CREB3L2_145_pLDDT.png (AA BP:125)
all structure
FUS_CREB3L2_145_pLDDT_and_active_sites.png (AA BP:125)
all structure
FUS_CREB3L2_145_violinplot.png (AA BP:125)
all structure
FUS_CREB3L2_147_PAE.png (AA BP:)
all structure
FUS_CREB3L2_220_PAE.png (AA BP:125)
all structure
FUS_CREB3L2_220_pLDDT.png (AA BP:125)
all structure
FUS_CREB3L2_220_pLDDT_and_active_sites.png (AA BP:125)
all structure
FUS_CREB3L2_220_violinplot.png (AA BP:125)
all structure
FUS_CREB3L2_221_PAE.png (AA BP:126)
all structure
FUS_CREB3L2_221_pLDDT.png (AA BP:126)
all structure
FUS_CREB3L2_221_pLDDT_and_active_sites.png (AA BP:126)
all structure
FUS_CREB3L2_221_violinplot.png (AA BP:126)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
FUS_CREB3L2_145.png
all structure
FUS_CREB3L2_147.png
all structure
FUS_CREB3L2_220.png
all structure
FUS_CREB3L2_221.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
1451.0421441.104362.2080.5750.6730.8841.1980.7351.630.869Chain A: 193,194,195,196,197,202,204,205,208,210,2
12,213,214,215,216,218,222,223,224,225,226,227,228
,229,230,232,233,236
1471.089971.197240.10.5310.6560.9252.0210.3745.41.53Chain A: 52,53,55,58,59,61,62,63,65,66,67,69,318,3
19,322,323,326,327,330
2200.945690.993181.1040.5990.670.8991.8750.583.2311.643Chain A: 193,194,195,196,197,202,205,210,211,212,2
13,215,216,218,221,222,225,226,229
2210.912690.936197.2250.5770.670.8880.850.7591.1211.093Chain A: 194,195,196,197,198,203,206,213,214,215,2
17,219,223,226,227,230,231

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
FUSEIF6, USF2, PRMT1, PTBP2, SRRM1, SPI1, YBX1, ILF3, SF1, SRSF10, THRA, RXRA, RELA, OTUB1, ZMYM2, SARNP, TARDBP, Mapk13, DGCR8, Pds5a, Shoc2, Ccdc15, PCM1, SF3A2, SIRT7, SQSTM1, TDRD3, CUL3, CUL4A, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, ARHGEF28, PA2G4, UBE2I, ATXN1L, GRB2, PIK3R2, HNRNPA3, NONO, EEF1A1, DYNC1H1, GSE1, MBD3, MRPS18B, SAP30BP, RPLP1, ESR1, FN1, VCAM1, TP63, IL7R, UBL4A, ITGA4, CTNNB1, ECM32, NAM8, SBP1, SKO1, VHR1, UPF1, LMNA, EWSR1, RBMX, PSMB7, ESRRA, MDH1, TAF15, SRSF9, SAFB2, TNIP1, KHDRBS3, NKD2, MAX, PARK2, SUV39H1, WBP4, HNRNPU, LARS, rev, RPA3, RPA2, RPA1, WWOX, HSPA5, VCP, SFPQ, YWHAZ, YWHAQ, PFN1, FASN, PGK1, CKB, ENO1, LDHB, PAICS, PHGDH, LDHA, GAPDH, PKM, ATXN2L, MTHFD1, ACACA, CA2, ALDOA, GPI, PYCRL, PFKL, PGM1, ABCA1, HPRT1, PM20D2, TKT, UBA1, PSMD12, CDH4, ANXA2P2, GNAS, PLCE1, TRPM4, SLC1A5, UBAP2, UBAP2L, LYZ, CKAP4, YPEL1, HIST4H4, H3F3A, H3F3B, HIST2H2BE, DDX42, HNRNPD, SYNCRIP, DHX40, SF3A1, SF3B3, SF3B4, SERBP1, FANCM, RAD54B, PCNA, PHB, TP73, RPL18, RPL9, RPS9, TBPL1, TRIP4, DNAJC10, SAE1, DLD, GOT2, ATP5A1, GSTP1, HARS2, SLC25A3, KPNA2, RAB7A, SPATA6, UACA, STATH, ANXA5, MAP3K3, UBC, TUBB, CFL1, TUBA1A, ACTB, HNRNPF, HNRNPH1, DHX15, CPSF6, SF3A3, HNRNPK, PSPC1, HNRNPL, RPS5, RPS8, RPL12, RPN2, EEF2, EEF1G, HSP90AA1, CCT5, CCT6A, HSP90AB1, CCT2, CCT4, HSP90B1, CCT3, CCT7, CCT8, HSPA8, PPIL4, TCP1, PDIA3, PPIA, SSBP1, GLUD1, ATP5B, HSPA9, ERAL1, TUFM, HSPD1, PYCR1, MDH2, ABCF2, KPNB1, PRDX1, ERP44, F7, ALB, ARMC6, ADCK5, CCDC88A, GPR101, ITK, DGKA, SLC22A11, HERC6, TUBA1B, MTSS1L, CEP112, COL18A1, SEC13, NAP1L1, SNRPD2, NCAPG2, RBBP4, FLJ22447, LSM12, NUDT21, DDX1, C14orf166, DDX5, HIVEP3, NCOA6, RAVER1, TCEB1, TXNL4B, TTI2, GEN1, RPL14, RPS14, NPM1, RPL11, RPL4, EIF4A1, PCBP2, ST13, NSDHL, MTAP, MAT2A, AHCY, OAT, BCS1L, SLC25A5, TIMM50, MYH10, GOLIM4, CSE1L, RAN, KLHL40, KLHL5, IGKV1-5, C6, GIMAP8, CDC5L, CEP78, DBF4B, AMOT, FAM71F1, MFGE8, FAM98A, C11orf70, RTCB, UFL1, LRRIQ4, NUPR1, CUL7, OBSL1, EZH2, SUZ12, BMI1, ABL1, CHEK1, SIK2, SRPK1, DBR1, LUZP4, UPF2, UPF3A, FAM58A, YEATS4, RPS6KB2, HNRNPA1, HSP104, FBXW11, ACAT1, ARMC1, C2orf49, DDX17, DNAJC7, EIF4H, AURKA, PTBP1, TOMM34, TXLNA, UFD1L, HNRNPDL, MEF2D, NAA50, NPLOC4, PFKP, PICALM, TARS, NTRK1, SCARNA22, TCF7L2, KIF22, EMC2, MATR3, MCM2, SNW1, RC3H1, EGFR, TRAF6, CRBN, KCTD6, RPS27, PSRC1, SMCO3, CYLD, TRIM25, BRCA1, HDAC6, WDR77, PCBP1, PPIE, YAP1, EFTUD2, AAR2, PIH1D1, NKX2-1, CHD3, CHD4, TNF, HEXIM1, MEPCE, LARP7, RUNX1, PPT1, CTDSPL2, AGR2, RECQL4, CDK9, ARID1A, SMARCA4, SMARCD1, DDIT3, SMARCC2, SMARCC1, SS18, SMARCB1, FLI1, TP53BP1, MDC1, METTL3, METTL14, KIAA1429, RC3H2, ATG16L1, LINC00470, AKT1, ACTC1, RBX1, MYC, MAPT, HIV2gp4, HIV2gp3, NR2C2, UBQLN2, HDAC2, ZFYVE21, XRCC6, DYNLT1, HIST1H4A, SNRNP70, SNRPA, SRSF1, SNRPB, SNRPC, SNRPD1, SNRPD3, RNU1-1, FUS, TRIM28, HNRNPA2B1, HNRNPR, PPP1R10, ILF2, DHX9, PABPC1, DDX3X, SRSF7, HNRNPM, HNRNPUL1, PABPC4, SF3B1, LARP1, PBRM1, THRAP3, MOV10, FAM120A, SKIV2L2, TOX, POLR2A, ELAVL1, SF3B2, STRBP, WDR82, HNRNPCL1, CCNT1, RBM14, U2SURP, DDX20, HIST1H1C, NUMA1, CCBL2, ZFR, ACIN1, CDC73, DDX23, SLTM, SRRT, IGF2BP3, ZC3H18, PRRC2A, HNRNPUL2, THOC1, AKAP8, BCLAF1, SRSF3, CHERP, INTS12, PAF1, PNN, PPFIA1, RBM10, SNRNP200, TOE1, TRA2B, HNRNPC, HNRNPA0, PPP1CC, CCAR1, DDX21, HNRNPAB, INTS6, POLR2B, PRPF6, RALY, RBM25, RBM7, SAFB, THOC5, XRN2, EBNA1BP2, HSPA1A, RBM39, STRAP, TRA2A, YBX3, ZCCHC8, GPATCH8, SMN1, SRSF5, CTR9, EIF4A3, GNL3, HNRNPH3, HP1BP3, NCBP1, PRPF19, RBM17, RRP9, THOC2, ZC3HAV1, EXOSC10, GEMIN6, XAB2, HSPB1, PABPN1, CAPRIN1, CCAR2, GEMIN4, INTS4, KHDRBS1, PLRG1, PRMT5, SRSF6, ZNF326, ADAR, ARID2, GEMIN5, PHF10, PURB, SMU1, TOX4, AQR, ITFG1, ARAF, BIRC3, NFX1, VPS15, VPS34, VPS38, VPS8, PEP3, VPS21, CDC48, UBX3, BRE5, UBP3, SOX2, EP300, CMTR1, ARIH2, PLEKHA4, PINK1, PRMT8, FANCD2, MIRLET7A1, MIRLET7A2, MIRLET7A3, MIRLET7B, MIRLET7C, MIRLET7D, MIRLET7E, MIRLET7F1, MIRLET7F2, MIRLET7G, MIRLET7I, MIR98, MIR1-1, MIR1-2, MIR7-1, MIR7-2, MIR7-3, MIR9-1, MIR9-2, MIR9-3, MIR10B, MIR15A, MIR15B, MIR16-1, MIR16-2, MIR17, MIR18A, MIR18B, MIR19A, MIR19B1, MIR19B2, MIR20A, MIR20B, MIR21, MIR25, MIR29A, MIR29B1, MIR29B2, MIR29C, MIR31, MIR34A, MIR34B, MIR34C, MIR92A1, MIR92A2, MIR93, MIR106A, MIR106B, MIR107, MIR122, MIR128-1, MIR128-2, MIR138-1, MIR138-2, MIR140, MIR141, MIR143, MIR145, MIR155, MIR199A1, MIR199A2, MIR200A, MIR200B, MIR200C, MIR205, MIR206, MIR214, MIR221, MIR222, MIR363, MIR429, MIR451A, ADAMTS9-AS2, MDM2, OPTN, PRKD1, HVCN1, CELF1, FUBP3, DUX4, DUX4L9, CIT, CHMP4B, ECT2, KIF14, KIF20A, KIF23, PRC1, MKI67, BRD4, NINL, RBM45, UCHL1, Apc2, FBP1, LGALS9, WDR76, EIF3F, CREBBP, vpr, RNF4, OGT, CD274, SPOP, DDRGK1, TP53, DDX39B, HIST1H2BG, USP15, FZR1, WDR5, NUDCD2, CPSF1, NUP43, BTF3, BSG, S, RCHY1, NBR1, BACH2, PDE4B, SIRT6,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
FUSall structure
CREB3L2all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to FUS-CREB3L2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to FUS-CREB3L2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
FUSCREB3L2Low Grade Fibromyxoid SarcomaMyCancerGenome
FUSCREB3L2Lung AdenocarcinomaMyCancerGenome
FUSCREB3L2Breast Invasive Ductal CarcinomaMyCancerGenome
FUSCREB3L2GlioblastomaMyCancerGenome
FUSCREB3L2Pancreatic AdenocarcinomaMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFUSC1842675AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)5UNIPROT
HgeneFUSC3468114Juvenile amyotrophic lateral sclerosis5ORPHANET
HgeneFUSC0002736Amyotrophic Lateral Sclerosis2CTD_human;ORPHANET
HgeneFUSC0206634Liposarcoma, Myxoid2CTD_human;ORPHANET
HgeneFUSC0393554Amyotrophic Lateral Sclerosis With Dementia1CTD_human
HgeneFUSC0497327Dementia1GENOMICS_ENGLAND
HgeneFUSC0543859Amyotrophic Lateral Sclerosis, Guam Form1CTD_human
HgeneFUSC3539195TREMOR, HEREDITARY ESSENTIAL, 41CTD_human;UNIPROT
HgeneFUSC3888102Frontotemporal Dementia With Motor Neuron Disease1ORPHANET