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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:GABRB3-FAF1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: GABRB3-FAF1
FusionPDB ID: 32119
FusionGDB2.0 ID: 32119
HgeneTgene
Gene symbol

GABRB3

FAF1

Gene ID

2562

11124

Gene namegamma-aminobutyric acid type A receptor subunit beta3Fas associated factor 1
SynonymsECA5|EIEE43CGI-03|HFAF1s|UBXD12|UBXN3A|hFAF1
Cytomap

15q12

1p32.3

Type of geneprotein-codingprotein-coding
Descriptiongamma-aminobutyric acid receptor subunit beta-3GABA-alpha receptor beta-2 subunitGABAA receptor beta-3 subunitgamma-aminobutyric acid (GABA) A receptor, beta 3gamma-aminobutyric acid A receptor beta 3gamma-aminobutyric acid type A receptor beta3 subuFAS-associated factor 1Fas (TNFRSF6) associated factor 1TNFRSF6-associated factor 1UBX domain protein 3AUBX domain-containing protein 12UBX domain-containing protein 3A
Modification date2020032020200313
UniProtAcc

P28472

Q9UNN5

Ensembl transtripts involved in fusion geneENST idsENST00000299267, ENST00000311550, 
ENST00000541819, ENST00000557641, 
ENST00000400188, ENST00000545868, 
ENST00000472808, ENST00000545823, 
ENST00000371778, ENST00000396153, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 9 X 2=16228 X 23 X 14=9016
# samples 931
** MAII scorelog2(9/162*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(31/9016*10)=-4.86214739489798
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: GABRB3 [Title/Abstract] AND FAF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GABRB3(27017548)-FAF1(51323670), # samples:1
Anticipated loss of major functional domain due to fusion event.GABRB3-FAF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GABRB3-FAF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GABRB3-FAF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GABRB3-FAF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGABRB3

GO:0071420

cellular response to histamine

18281286

HgeneGABRB3

GO:1902476

chloride transmembrane transport

9039914

HgeneGABRB3

GO:1904862

inhibitory synapse assembly

25489750

TgeneFAF1

GO:0010942

positive regulation of cell death

15596450


check buttonFusion gene breakpoints across GABRB3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FAF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADA493815GABRB3chr15

27017548

-FAF1chr1

51323670

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000311550GABRB3chr1527017548-ENST00000396153FAF1chr151323670-42223521122259715
ENST00000311550GABRB3chr1527017548-ENST00000371778FAF1chr151323670-26633521122259715
ENST00000541819GABRB3chr1527017548-ENST00000396153FAF1chr151323670-4381511762418780
ENST00000541819GABRB3chr1527017548-ENST00000371778FAF1chr151323670-2822511762418780
ENST00000299267GABRB3chr1527017548-ENST00000396153FAF1chr151323670-417430412211736
ENST00000299267GABRB3chr1527017548-ENST00000371778FAF1chr151323670-261530412211736

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000311550ENST00000396153GABRB3chr1527017548-FAF1chr151323670-0.000368810.99963117
ENST00000311550ENST00000371778GABRB3chr1527017548-FAF1chr151323670-0.0007811830.9992188
ENST00000541819ENST00000396153GABRB3chr1527017548-FAF1chr151323670-0.0004277580.9995722
ENST00000541819ENST00000371778GABRB3chr1527017548-FAF1chr151323670-0.0008992660.9991008
ENST00000299267ENST00000396153GABRB3chr1527017548-FAF1chr151323670-0.0002169050.9997831
ENST00000299267ENST00000371778GABRB3chr1527017548-FAF1chr151323670-0.0005278430.9994722

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>32119_32119_1_GABRB3-FAF1_GABRB3_chr15_27017548_ENST00000299267_FAF1_chr1_51323670_ENST00000371778_length(amino acids)=736AA_BP=101
LAARRVGGRADPSRLGRRNSAMCSGLLELLLPIWLSWTLGTRGSEPRSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDI
ASIDMVSEVNMACTGIENIDEAITLLEQNNWDLVAAINGVIPQENGILQSEYGGETIPGPAFNPASHPASAPTSSSSSAFRPVMPSRQIV
ERQPRMLDFRVEYRDRNVDVVLEDTCTVGEIKQILENELQIPVSKMLLKGWKTGDVEDSTVLKSLHLPKNNSLYVLTPDLPPPSSSSHAG
ALQESLNQNFMLIITHREVQREYNLNFSGSSTIQEVKRNVYDLTSIPVRHQLWEGWPTSATDDSMCLAESGLSYPCHRLTVGRRSSPAQT
REQSEEQITDVHMVSDSDGDDFEDATEFGVDDGEVFGMASSALRKSPMMPENAENEGDALLQFTAEFSSRYGDCHPVFFIGSLEAAFQEA
FYVKARDRKLLAIYLHHDESVLTNVFCSQMLCAESIVSYLSQNFITWAWDLTKDSNRARFLTMCNRHFGSVVAQTIRTQKTDQFPLFLII
MGKRSSNEVLNVIQGNTTVDELMMRLMAAMEIFTAQQQEDIKDEDEREARENVKREQDEAYRLSLEADRAKREAHEREMAEQFRLEQIRK
EQEEEREAIRLSLEQALPPEPKEENAEPVSKLRIRTPSGEFLERRFLASNKLQIVFDFVASKGFPWDEYKLLSTFPRRDVTQLDPNKSLL

--------------------------------------------------------------

>32119_32119_2_GABRB3-FAF1_GABRB3_chr15_27017548_ENST00000299267_FAF1_chr1_51323670_ENST00000396153_length(amino acids)=736AA_BP=101
LAARRVGGRADPSRLGRRNSAMCSGLLELLLPIWLSWTLGTRGSEPRSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDI
ASIDMVSEVNMACTGIENIDEAITLLEQNNWDLVAAINGVIPQENGILQSEYGGETIPGPAFNPASHPASAPTSSSSSAFRPVMPSRQIV
ERQPRMLDFRVEYRDRNVDVVLEDTCTVGEIKQILENELQIPVSKMLLKGWKTGDVEDSTVLKSLHLPKNNSLYVLTPDLPPPSSSSHAG
ALQESLNQNFMLIITHREVQREYNLNFSGSSTIQEVKRNVYDLTSIPVRHQLWEGWPTSATDDSMCLAESGLSYPCHRLTVGRRSSPAQT
REQSEEQITDVHMVSDSDGDDFEDATEFGVDDGEVFGMASSALRKSPMMPENAENEGDALLQFTAEFSSRYGDCHPVFFIGSLEAAFQEA
FYVKARDRKLLAIYLHHDESVLTNVFCSQMLCAESIVSYLSQNFITWAWDLTKDSNRARFLTMCNRHFGSVVAQTIRTQKTDQFPLFLII
MGKRSSNEVLNVIQGNTTVDELMMRLMAAMEIFTAQQQEDIKDEDEREARENVKREQDEAYRLSLEADRAKREAHEREMAEQFRLEQIRK
EQEEEREAIRLSLEQALPPEPKEENAEPVSKLRIRTPSGEFLERRFLASNKLQIVFDFVASKGFPWDEYKLLSTFPRRDVTQLDPNKSLL

--------------------------------------------------------------

>32119_32119_3_GABRB3-FAF1_GABRB3_chr15_27017548_ENST00000311550_FAF1_chr1_51323670_ENST00000371778_length(amino acids)=715AA_BP=80
MWGLAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMACTGIENIDE
AITLLEQNNWDLVAAINGVIPQENGILQSEYGGETIPGPAFNPASHPASAPTSSSSSAFRPVMPSRQIVERQPRMLDFRVEYRDRNVDVV
LEDTCTVGEIKQILENELQIPVSKMLLKGWKTGDVEDSTVLKSLHLPKNNSLYVLTPDLPPPSSSSHAGALQESLNQNFMLIITHREVQR
EYNLNFSGSSTIQEVKRNVYDLTSIPVRHQLWEGWPTSATDDSMCLAESGLSYPCHRLTVGRRSSPAQTREQSEEQITDVHMVSDSDGDD
FEDATEFGVDDGEVFGMASSALRKSPMMPENAENEGDALLQFTAEFSSRYGDCHPVFFIGSLEAAFQEAFYVKARDRKLLAIYLHHDESV
LTNVFCSQMLCAESIVSYLSQNFITWAWDLTKDSNRARFLTMCNRHFGSVVAQTIRTQKTDQFPLFLIIMGKRSSNEVLNVIQGNTTVDE
LMMRLMAAMEIFTAQQQEDIKDEDEREARENVKREQDEAYRLSLEADRAKREAHEREMAEQFRLEQIRKEQEEEREAIRLSLEQALPPEP

--------------------------------------------------------------

>32119_32119_4_GABRB3-FAF1_GABRB3_chr15_27017548_ENST00000311550_FAF1_chr1_51323670_ENST00000396153_length(amino acids)=715AA_BP=80
MWGLAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMACTGIENIDE
AITLLEQNNWDLVAAINGVIPQENGILQSEYGGETIPGPAFNPASHPASAPTSSSSSAFRPVMPSRQIVERQPRMLDFRVEYRDRNVDVV
LEDTCTVGEIKQILENELQIPVSKMLLKGWKTGDVEDSTVLKSLHLPKNNSLYVLTPDLPPPSSSSHAGALQESLNQNFMLIITHREVQR
EYNLNFSGSSTIQEVKRNVYDLTSIPVRHQLWEGWPTSATDDSMCLAESGLSYPCHRLTVGRRSSPAQTREQSEEQITDVHMVSDSDGDD
FEDATEFGVDDGEVFGMASSALRKSPMMPENAENEGDALLQFTAEFSSRYGDCHPVFFIGSLEAAFQEAFYVKARDRKLLAIYLHHDESV
LTNVFCSQMLCAESIVSYLSQNFITWAWDLTKDSNRARFLTMCNRHFGSVVAQTIRTQKTDQFPLFLIIMGKRSSNEVLNVIQGNTTVDE
LMMRLMAAMEIFTAQQQEDIKDEDEREARENVKREQDEAYRLSLEADRAKREAHEREMAEQFRLEQIRKEQEEEREAIRLSLEQALPPEP

--------------------------------------------------------------

>32119_32119_5_GABRB3-FAF1_GABRB3_chr15_27017548_ENST00000541819_FAF1_chr1_51323670_ENST00000371778_length(amino acids)=780AA_BP=145
MAVSQVQSEMQQLRRLWVLAAQPFCHLPERCRLFFEIGGISLAMPQCLLWICLAVWEARGDLPFIAENDAVLTVNWNAVKEHRTFYAIYE
TSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMACTGIENIDEAITLLEQNNWDLVAAINGVIPQENG
ILQSEYGGETIPGPAFNPASHPASAPTSSSSSAFRPVMPSRQIVERQPRMLDFRVEYRDRNVDVVLEDTCTVGEIKQILENELQIPVSKM
LLKGWKTGDVEDSTVLKSLHLPKNNSLYVLTPDLPPPSSSSHAGALQESLNQNFMLIITHREVQREYNLNFSGSSTIQEVKRNVYDLTSI
PVRHQLWEGWPTSATDDSMCLAESGLSYPCHRLTVGRRSSPAQTREQSEEQITDVHMVSDSDGDDFEDATEFGVDDGEVFGMASSALRKS
PMMPENAENEGDALLQFTAEFSSRYGDCHPVFFIGSLEAAFQEAFYVKARDRKLLAIYLHHDESVLTNVFCSQMLCAESIVSYLSQNFIT
WAWDLTKDSNRARFLTMCNRHFGSVVAQTIRTQKTDQFPLFLIIMGKRSSNEVLNVIQGNTTVDELMMRLMAAMEIFTAQQQEDIKDEDE
REARENVKREQDEAYRLSLEADRAKREAHEREMAEQFRLEQIRKEQEEEREAIRLSLEQALPPEPKEENAEPVSKLRIRTPSGEFLERRF

--------------------------------------------------------------

>32119_32119_6_GABRB3-FAF1_GABRB3_chr15_27017548_ENST00000541819_FAF1_chr1_51323670_ENST00000396153_length(amino acids)=780AA_BP=145
MAVSQVQSEMQQLRRLWVLAAQPFCHLPERCRLFFEIGGISLAMPQCLLWICLAVWEARGDLPFIAENDAVLTVNWNAVKEHRTFYAIYE
TSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMACTGIENIDEAITLLEQNNWDLVAAINGVIPQENG
ILQSEYGGETIPGPAFNPASHPASAPTSSSSSAFRPVMPSRQIVERQPRMLDFRVEYRDRNVDVVLEDTCTVGEIKQILENELQIPVSKM
LLKGWKTGDVEDSTVLKSLHLPKNNSLYVLTPDLPPPSSSSHAGALQESLNQNFMLIITHREVQREYNLNFSGSSTIQEVKRNVYDLTSI
PVRHQLWEGWPTSATDDSMCLAESGLSYPCHRLTVGRRSSPAQTREQSEEQITDVHMVSDSDGDDFEDATEFGVDDGEVFGMASSALRKS
PMMPENAENEGDALLQFTAEFSSRYGDCHPVFFIGSLEAAFQEAFYVKARDRKLLAIYLHHDESVLTNVFCSQMLCAESIVSYLSQNFIT
WAWDLTKDSNRARFLTMCNRHFGSVVAQTIRTQKTDQFPLFLIIMGKRSSNEVLNVIQGNTTVDELMMRLMAAMEIFTAQQQEDIKDEDE
REARENVKREQDEAYRLSLEADRAKREAHEREMAEQFRLEQIRKEQEEEREAIRLSLEQALPPEPKEENAEPVSKLRIRTPSGEFLERRF

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:27017548/chr1:51323670)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GABRB3

P28472

FAF1

Q9UNN5

FUNCTION: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:18514161, PubMed:22303015, PubMed:26950270, PubMed:22243422, PubMed:24909990). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:25489750). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta3/gamma2 receptor exhibits synaptogenic activity (PubMed:25489750). The alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (PubMed:18281286). Plays an important role in somatosensation and in the production of antinociception (By similarity). {ECO:0000250|UniProtKB:P63080, ECO:0000269|PubMed:18281286, ECO:0000269|PubMed:18514161, ECO:0000269|PubMed:22243422, ECO:0000269|PubMed:22303015, ECO:0000269|PubMed:24909990, ECO:0000269|PubMed:25489750, ECO:0000269|PubMed:26950270}.FUNCTION: Ubiquitin-binding protein (PubMed:19722279). Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (PubMed:26842564). Potentiates but cannot initiate FAS-induced apoptosis (By similarity). {ECO:0000250|UniProtKB:P54731, ECO:0000269|PubMed:19722279, ECO:0000269|PubMed:26842564}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFAF1chr15:27017548chr1:51323670ENST00000371778120569_64615.0651.0DomainUBX
TgeneFAF1chr15:27017548chr1:51323670ENST00000396153019569_64615.0651.0DomainUBX

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGABRB3chr15:27017548chr1:51323670ENST00000299267-39120_12280.0474.0RegionNote=Agonist binding
HgeneGABRB3chr15:27017548chr1:51323670ENST00000299267-39180_18280.0474.0RegionNote=Agonist binding
HgeneGABRB3chr15:27017548chr1:51323670ENST00000299267-39290_31180.0474.0RegionNote=Allosteric effector binding
HgeneGABRB3chr15:27017548chr1:51323670ENST00000311550-39120_12280.0474.0RegionNote=Agonist binding
HgeneGABRB3chr15:27017548chr1:51323670ENST00000311550-39180_18280.0474.0RegionNote=Agonist binding
HgeneGABRB3chr15:27017548chr1:51323670ENST00000311550-39290_31180.0474.0RegionNote=Allosteric effector binding
HgeneGABRB3chr15:27017548chr1:51323670ENST00000400188-17120_1220403.0RegionNote=Agonist binding
HgeneGABRB3chr15:27017548chr1:51323670ENST00000400188-17180_1820403.0RegionNote=Agonist binding
HgeneGABRB3chr15:27017548chr1:51323670ENST00000400188-17290_3110403.0RegionNote=Allosteric effector binding
HgeneGABRB3chr15:27017548chr1:51323670ENST00000545868-17120_1220389.0RegionNote=Agonist binding
HgeneGABRB3chr15:27017548chr1:51323670ENST00000545868-17180_1820389.0RegionNote=Agonist binding
HgeneGABRB3chr15:27017548chr1:51323670ENST00000545868-17290_3110389.0RegionNote=Allosteric effector binding
HgeneGABRB3chr15:27017548chr1:51323670ENST00000299267-39268_27080.0474.0Topological domainCytoplasmic
HgeneGABRB3chr15:27017548chr1:51323670ENST00000299267-3926_24580.0474.0Topological domainExtracellular
HgeneGABRB3chr15:27017548chr1:51323670ENST00000299267-39294_30480.0474.0Topological domainExtracellular
HgeneGABRB3chr15:27017548chr1:51323670ENST00000299267-39328_45080.0474.0Topological domainCytoplasmic
HgeneGABRB3chr15:27017548chr1:51323670ENST00000311550-39268_27080.0474.0Topological domainCytoplasmic
HgeneGABRB3chr15:27017548chr1:51323670ENST00000311550-3926_24580.0474.0Topological domainExtracellular
HgeneGABRB3chr15:27017548chr1:51323670ENST00000311550-39294_30480.0474.0Topological domainExtracellular
HgeneGABRB3chr15:27017548chr1:51323670ENST00000311550-39328_45080.0474.0Topological domainCytoplasmic
HgeneGABRB3chr15:27017548chr1:51323670ENST00000400188-17268_2700403.0Topological domainCytoplasmic
HgeneGABRB3chr15:27017548chr1:51323670ENST00000400188-1726_2450403.0Topological domainExtracellular
HgeneGABRB3chr15:27017548chr1:51323670ENST00000400188-17294_3040403.0Topological domainExtracellular
HgeneGABRB3chr15:27017548chr1:51323670ENST00000400188-17328_4500403.0Topological domainCytoplasmic
HgeneGABRB3chr15:27017548chr1:51323670ENST00000545868-17268_2700389.0Topological domainCytoplasmic
HgeneGABRB3chr15:27017548chr1:51323670ENST00000545868-1726_2450389.0Topological domainExtracellular
HgeneGABRB3chr15:27017548chr1:51323670ENST00000545868-17294_3040389.0Topological domainExtracellular
HgeneGABRB3chr15:27017548chr1:51323670ENST00000545868-17328_4500389.0Topological domainCytoplasmic
HgeneGABRB3chr15:27017548chr1:51323670ENST00000299267-39246_26780.0474.0TransmembraneNote=Helical
HgeneGABRB3chr15:27017548chr1:51323670ENST00000299267-39271_29380.0474.0TransmembraneNote=Helical
HgeneGABRB3chr15:27017548chr1:51323670ENST00000299267-39305_32780.0474.0TransmembraneNote=Helical
HgeneGABRB3chr15:27017548chr1:51323670ENST00000299267-39451_47280.0474.0TransmembraneNote=Helical
HgeneGABRB3chr15:27017548chr1:51323670ENST00000311550-39246_26780.0474.0TransmembraneNote=Helical
HgeneGABRB3chr15:27017548chr1:51323670ENST00000311550-39271_29380.0474.0TransmembraneNote=Helical
HgeneGABRB3chr15:27017548chr1:51323670ENST00000311550-39305_32780.0474.0TransmembraneNote=Helical
HgeneGABRB3chr15:27017548chr1:51323670ENST00000311550-39451_47280.0474.0TransmembraneNote=Helical
HgeneGABRB3chr15:27017548chr1:51323670ENST00000400188-17246_2670403.0TransmembraneNote=Helical
HgeneGABRB3chr15:27017548chr1:51323670ENST00000400188-17271_2930403.0TransmembraneNote=Helical
HgeneGABRB3chr15:27017548chr1:51323670ENST00000400188-17305_3270403.0TransmembraneNote=Helical
HgeneGABRB3chr15:27017548chr1:51323670ENST00000400188-17451_4720403.0TransmembraneNote=Helical
HgeneGABRB3chr15:27017548chr1:51323670ENST00000545868-17246_2670389.0TransmembraneNote=Helical
HgeneGABRB3chr15:27017548chr1:51323670ENST00000545868-17271_2930389.0TransmembraneNote=Helical
HgeneGABRB3chr15:27017548chr1:51323670ENST00000545868-17305_3270389.0TransmembraneNote=Helical
HgeneGABRB3chr15:27017548chr1:51323670ENST00000545868-17451_4720389.0TransmembraneNote=Helical
TgeneFAF1chr15:27017548chr1:51323670ENST000003717781201_5715.0651.0DomainUBA
TgeneFAF1chr15:27017548chr1:51323670ENST000003961530191_5715.0651.0DomainUBA


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
GABRB3
FAF1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to GABRB3-FAF1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to GABRB3-FAF1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource