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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:GC-DSP

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: GC-DSP
FusionPDB ID: 32749
FusionGDB2.0 ID: 32749
HgeneTgene
Gene symbol

GC

DSP

Gene ID

2638

1834

Gene nameGC vitamin D binding proteindentin sialophosphoprotein
SynonymsDBP|DBP-maf|DBP/GC|GRD3|Gc-MAF|GcMAF|HEL-S-51|VDB|VDBG|VDBPDFNA39|DGI1|DMP3|DPP|DSP
Cytomap

4q13.3

4q22.1

Type of geneprotein-codingprotein-coding
Descriptionvitamin D-binding proteinepididymis secretory protein Li 51gc protein-derived macrophage activating factorgc-globulingroup-specific component (vitamin D binding protein)vitamin D-binding alpha-globulinvitamin D-binding protein-macrophage activating dentin sialophosphoproteindeafness, autosomal dominant 39dentin phosphophoryndentin phosphoproteindentin phosphoryndentin sialoprotein
Modification date2020032920200313
UniProtAcc

P23434

P15924

Ensembl transtripts involved in fusion geneENST idsENST00000273951, ENST00000504199, 
ENST00000503472, ENST00000513476, 
ENST00000379802, ENST00000418664, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score3 X 3 X 3=2722 X 19 X 10=4180
# samples 326
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(26/4180*10)=-4.00691941393979
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: GC [Title/Abstract] AND DSP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GC(72607413)-DSP(7575528), # samples:1
Anticipated loss of major functional domain due to fusion event.GC-DSP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GC-DSP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GC-DSP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GC-DSP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across GC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DSP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-DD-A3A8-01AGCchr4

72607413

-DSPchr6

7575528

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000273951GCchr472607413-ENST00000379802DSPchr67575528+89911972191581512078
ENST00000273951GCchr472607413-ENST00000418664DSPchr67575528+70491972191563541479
ENST00000504199GCchr472607413-ENST00000379802DSPchr67575528+87961777172379562077
ENST00000504199GCchr472607413-ENST00000418664DSPchr67575528+68541777172361591478

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000273951ENST00000379802GCchr472607413-DSPchr67575528+0.007692240.9923078
ENST00000273951ENST00000418664GCchr472607413-DSPchr67575528+0.0040432340.9959567
ENST00000504199ENST00000379802GCchr472607413-DSPchr67575528+0.008763310.9912367
ENST00000504199ENST00000418664GCchr472607413-DSPchr67575528+0.0045099680.99549

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>32749_32749_1_GC-DSP_GC_chr4_72607413_ENST00000273951_DSP_chr6_7575528_ENST00000379802_length(amino acids)=2078AA_BP=19
MTSMMICYQNKLKYNANHKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEK
QIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLE
TLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQ
KYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENL
GWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLS
RENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAE
FQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENL
RRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYD
LQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRR
SLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKS
RSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQE
IEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSR
KEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDT
SKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQA
ATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL
PKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGILRPSTV
NELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI
EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTK
GFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW
EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKI
STISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD
MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKI
LTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS

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>32749_32749_2_GC-DSP_GC_chr4_72607413_ENST00000273951_DSP_chr6_7575528_ENST00000418664_length(amino acids)=1479AA_BP=19
MTSMMICYQNKLKYNANHKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEK
QIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLE
TLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQ
KYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENL
GWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKST
LEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETER
SRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGAS
ASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIK
KNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLS
VQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL
EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKE
SHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPE
TNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMIS
LKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLE
AQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVH
GRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSG

--------------------------------------------------------------

>32749_32749_3_GC-DSP_GC_chr4_72607413_ENST00000504199_DSP_chr6_7575528_ENST00000379802_length(amino acids)=2077AA_BP=18
MTSMMICYQNKLKYNANHKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQ
IKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLET
LLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQK
YQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLG
WQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSR
ENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEF
QEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLR
RVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDL
QKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRS
LKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSR
SLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEI
EKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRK
EEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTS
KLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAA
TGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP
KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVN
ELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIE
FKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKG
FFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWE
EITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKIS
TISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDM
ATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKIL
TCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYSF

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>32749_32749_4_GC-DSP_GC_chr4_72607413_ENST00000504199_DSP_chr6_7575528_ENST00000418664_length(amino acids)=1478AA_BP=18
MTSMMICYQNKLKYNANHKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQ
IKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLET
LLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQK
YQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLG
WQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTL
EAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERS
RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASA
SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKK
NLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSV
QKRSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLE
AQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES
HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPET
NKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL
KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEA
QACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG
RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGS

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:72607413/chr6:7575528)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GC

P23434

DSP

P15924

FUNCTION: The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). {ECO:0000269|PubMed:1671321}.FUNCTION: Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGCchr4:72607413chr6:7575528ENST00000273951-131317_208542.6666666666666395.3333333333333DomainAlbumin 1
HgeneGCchr4:72607413chr6:7575528ENST00000273951-1313209_394542.6666666666666395.3333333333333DomainAlbumin 2
HgeneGCchr4:72607413chr6:7575528ENST00000273951-1313395_474542.6666666666666395.3333333333333DomainAlbumin 3
HgeneGCchr4:72607413chr6:7575528ENST00000504199-141417_208560.6666666666666500.6666666666667DomainAlbumin 1
HgeneGCchr4:72607413chr6:7575528ENST00000504199-1414209_394560.6666666666666500.6666666666667DomainAlbumin 2
HgeneGCchr4:72607413chr6:7575528ENST00000504199-1414395_474560.6666666666666500.6666666666667DomainAlbumin 3
TgeneDSPchr4:72607413chr6:7575528ENST0000037980216241018_1945812.02872.0Coiled coilOntology_term=ECO:0000255
TgeneDSPchr4:72607413chr6:7575528ENST0000041866416241018_1945812.02273.0Coiled coilOntology_term=ECO:0000255
TgeneDSPchr4:72607413chr6:7575528ENST0000037980216241057_1945812.02872.0RegionNote=Central fibrous rod domain
TgeneDSPchr4:72607413chr6:7575528ENST0000037980216241946_2871812.02872.0RegionNote=Globular 2
TgeneDSPchr4:72607413chr6:7575528ENST0000037980216241960_2208812.02872.0RegionNote=4.5 X 38 AA tandem repeats (Domain A)
TgeneDSPchr4:72607413chr6:7575528ENST0000037980216242244_2446812.02872.0RegionNote=4.5 X 38 AA tandem repeats (Domain B)
TgeneDSPchr4:72607413chr6:7575528ENST0000037980216242609_2822812.02872.0RegionNote=4.5 X 38 AA tandem repeats (Domain C)
TgeneDSPchr4:72607413chr6:7575528ENST0000037980216242824_2847812.02872.0RegionNote=6 X 4 AA tandem repeats of G-S-R-[SR]
TgeneDSPchr4:72607413chr6:7575528ENST0000041866416241057_1945812.02273.0RegionNote=Central fibrous rod domain
TgeneDSPchr4:72607413chr6:7575528ENST0000041866416241946_2871812.02273.0RegionNote=Globular 2
TgeneDSPchr4:72607413chr6:7575528ENST0000041866416241960_2208812.02273.0RegionNote=4.5 X 38 AA tandem repeats (Domain A)
TgeneDSPchr4:72607413chr6:7575528ENST0000041866416242244_2446812.02273.0RegionNote=4.5 X 38 AA tandem repeats (Domain B)
TgeneDSPchr4:72607413chr6:7575528ENST0000041866416242609_2822812.02273.0RegionNote=4.5 X 38 AA tandem repeats (Domain C)
TgeneDSPchr4:72607413chr6:7575528ENST0000041866416242824_2847812.02273.0RegionNote=6 X 4 AA tandem repeats of G-S-R-[SR]
TgeneDSPchr4:72607413chr6:7575528ENST0000037980216242009_2045812.02872.0RepeatNote=Plectin 1
TgeneDSPchr4:72607413chr6:7575528ENST0000037980216242046_2083812.02872.0RepeatNote=Plectin 2
TgeneDSPchr4:72607413chr6:7575528ENST0000037980216242084_2121812.02872.0RepeatNote=Plectin 3
TgeneDSPchr4:72607413chr6:7575528ENST0000037980216242122_2159812.02872.0RepeatNote=Plectin 4
TgeneDSPchr4:72607413chr6:7575528ENST0000037980216242163_2197812.02872.0RepeatNote=Plectin 5
TgeneDSPchr4:72607413chr6:7575528ENST0000037980216242198_2233812.02872.0RepeatNote=Plectin 6
TgeneDSPchr4:72607413chr6:7575528ENST0000037980216242251_2288812.02872.0RepeatNote=Plectin 7
TgeneDSPchr4:72607413chr6:7575528ENST0000037980216242289_2326812.02872.0RepeatNote=Plectin 8
TgeneDSPchr4:72607413chr6:7575528ENST0000037980216242327_2364812.02872.0RepeatNote=Plectin 9
TgeneDSPchr4:72607413chr6:7575528ENST0000037980216242365_2402812.02872.0RepeatNote=Plectin 10
TgeneDSPchr4:72607413chr6:7575528ENST0000037980216242406_2440812.02872.0RepeatNote=Plectin 11
TgeneDSPchr4:72607413chr6:7575528ENST0000037980216242456_2493812.02872.0RepeatNote=Plectin 12
TgeneDSPchr4:72607413chr6:7575528ENST0000037980216242507_2544812.02872.0RepeatNote=Plectin 13
TgeneDSPchr4:72607413chr6:7575528ENST0000037980216242610_2647812.02872.0RepeatNote=Plectin 14
TgeneDSPchr4:72607413chr6:7575528ENST0000037980216242648_2685812.02872.0RepeatNote=Plectin 15
TgeneDSPchr4:72607413chr6:7575528ENST0000037980216242724_2761812.02872.0RepeatNote=Plectin 16
TgeneDSPchr4:72607413chr6:7575528ENST0000037980216242762_2799812.02872.0RepeatNote=Plectin 17
TgeneDSPchr4:72607413chr6:7575528ENST0000041866416242009_2045812.02273.0RepeatNote=Plectin 1
TgeneDSPchr4:72607413chr6:7575528ENST0000041866416242046_2083812.02273.0RepeatNote=Plectin 2
TgeneDSPchr4:72607413chr6:7575528ENST0000041866416242084_2121812.02273.0RepeatNote=Plectin 3
TgeneDSPchr4:72607413chr6:7575528ENST0000041866416242122_2159812.02273.0RepeatNote=Plectin 4
TgeneDSPchr4:72607413chr6:7575528ENST0000041866416242163_2197812.02273.0RepeatNote=Plectin 5
TgeneDSPchr4:72607413chr6:7575528ENST0000041866416242198_2233812.02273.0RepeatNote=Plectin 6
TgeneDSPchr4:72607413chr6:7575528ENST0000041866416242251_2288812.02273.0RepeatNote=Plectin 7
TgeneDSPchr4:72607413chr6:7575528ENST0000041866416242289_2326812.02273.0RepeatNote=Plectin 8
TgeneDSPchr4:72607413chr6:7575528ENST0000041866416242327_2364812.02273.0RepeatNote=Plectin 9
TgeneDSPchr4:72607413chr6:7575528ENST0000041866416242365_2402812.02273.0RepeatNote=Plectin 10
TgeneDSPchr4:72607413chr6:7575528ENST0000041866416242406_2440812.02273.0RepeatNote=Plectin 11
TgeneDSPchr4:72607413chr6:7575528ENST0000041866416242456_2493812.02273.0RepeatNote=Plectin 12
TgeneDSPchr4:72607413chr6:7575528ENST0000041866416242507_2544812.02273.0RepeatNote=Plectin 13
TgeneDSPchr4:72607413chr6:7575528ENST0000041866416242610_2647812.02273.0RepeatNote=Plectin 14
TgeneDSPchr4:72607413chr6:7575528ENST0000041866416242648_2685812.02273.0RepeatNote=Plectin 15
TgeneDSPchr4:72607413chr6:7575528ENST0000041866416242724_2761812.02273.0RepeatNote=Plectin 16
TgeneDSPchr4:72607413chr6:7575528ENST0000041866416242762_2799812.02273.0RepeatNote=Plectin 17

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDSPchr4:72607413chr6:7575528ENST000003798021624458_515812.02872.0DomainSH3
TgeneDSPchr4:72607413chr6:7575528ENST000004186641624458_515812.02273.0DomainSH3
TgeneDSPchr4:72607413chr6:7575528ENST0000037980216241_1056812.02872.0RegionNote=Globular 1
TgeneDSPchr4:72607413chr6:7575528ENST0000041866416241_1056812.02273.0RegionNote=Globular 1
TgeneDSPchr4:72607413chr6:7575528ENST000003798021624178_271812.02872.0RepeatNote=Spectrin 1
TgeneDSPchr4:72607413chr6:7575528ENST000003798021624272_375812.02872.0RepeatNote=Spectrin 2
TgeneDSPchr4:72607413chr6:7575528ENST000003798021624376_446812.02872.0RepeatNote=Spectrin 3a
TgeneDSPchr4:72607413chr6:7575528ENST000003798021624516_545812.02872.0RepeatNote=Spectrin 3b
TgeneDSPchr4:72607413chr6:7575528ENST000003798021624546_627812.02872.0RepeatNote=Spectrin 4
TgeneDSPchr4:72607413chr6:7575528ENST000003798021624654_769812.02872.0RepeatNote=Spectrin 5
TgeneDSPchr4:72607413chr6:7575528ENST000003798021624770_883812.02872.0RepeatNote=Spectrin 6
TgeneDSPchr4:72607413chr6:7575528ENST000004186641624178_271812.02273.0RepeatNote=Spectrin 1
TgeneDSPchr4:72607413chr6:7575528ENST000004186641624272_375812.02273.0RepeatNote=Spectrin 2
TgeneDSPchr4:72607413chr6:7575528ENST000004186641624376_446812.02273.0RepeatNote=Spectrin 3a
TgeneDSPchr4:72607413chr6:7575528ENST000004186641624516_545812.02273.0RepeatNote=Spectrin 3b
TgeneDSPchr4:72607413chr6:7575528ENST000004186641624546_627812.02273.0RepeatNote=Spectrin 4
TgeneDSPchr4:72607413chr6:7575528ENST000004186641624654_769812.02273.0RepeatNote=Spectrin 5
TgeneDSPchr4:72607413chr6:7575528ENST000004186641624770_883812.02273.0RepeatNote=Spectrin 6


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
GC
DSP


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneDSPchr4:72607413chr6:7575528ENST0000037980216241_584812.02872.0plakophilin 1 and junction plakoglobin
TgeneDSPchr4:72607413chr6:7575528ENST0000041866416241_584812.02273.0plakophilin 1 and junction plakoglobin


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Related Drugs to GC-DSP


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to GC-DSP


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource