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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:GNB2L1-MAP4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: GNB2L1-MAP4
FusionPDB ID: 33710
FusionGDB2.0 ID: 33710
HgeneTgene
Gene symbol

GNB2L1

MAP4

Gene ID

10399

4134

Gene namereceptor for activated C kinase 1microtubule associated protein 4
SynonymsGNB2L1|Gnb2-rs1|H12.3|HLC-7|PIG21-
Cytomap

5q35.3

3p21.31

Type of geneprotein-codingprotein-coding
Descriptionreceptor of activated protein C kinase 1cell proliferation-inducing gene 21 proteinguanine nucleotide binding protein (G protein), beta polypeptide 2-like 1guanine nucleotide binding protein beta polypeptide 2-like 1guanine nucleotide-binding protein microtubule-associated protein 4MAP-4
Modification date2020031320200313
UniProtAcc.

Q9Y4K4

Ensembl transtripts involved in fusion geneENST idsENST00000376817, ENST00000511566, 
ENST00000511900, ENST00000512805, 
ENST00000456394, ENST00000504726, 
ENST00000505461, ENST00000514455, 
ENST00000441748, ENST00000462206, 
ENST00000264724, ENST00000420772, 
ENST00000434267, ENST00000439356, 
ENST00000360240, ENST00000383737, 
ENST00000395734, ENST00000426837, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 5 X 6=21019 X 21 X 12=4788
# samples 735
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(35/4788*10)=-3.77399632511117
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: GNB2L1 [Title/Abstract] AND MAP4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GNB2L1(180666066)-MAP4(47913590), # samples:2
Anticipated loss of major functional domain due to fusion event.GNB2L1-MAP4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GNB2L1-MAP4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GNB2L1-MAP4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GNB2L1-MAP4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGNB2L1

GO:0001934

positive regulation of protein phosphorylation

11312657|17108144

HgeneGNB2L1

GO:0030308

negative regulation of cell growth

9584165

HgeneGNB2L1

GO:0030335

positive regulation of cell migration

20499158

HgeneGNB2L1

GO:0031334

positive regulation of protein complex assembly

20541605

HgeneGNB2L1

GO:0032091

negative regulation of protein binding

20541605

HgeneGNB2L1

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

19785988

HgeneGNB2L1

GO:0043065

positive regulation of apoptotic process

20541605

HgeneGNB2L1

GO:0043547

positive regulation of GTPase activity

20499158

HgeneGNB2L1

GO:0051726

regulation of cell cycle

9584165

HgeneGNB2L1

GO:0071333

cellular response to glucose stimulus

20103773

HgeneGNB2L1

GO:0071363

cellular response to growth factor stimulus

20010870


check buttonFusion gene breakpoints across GNB2L1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MAP4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-R6-A6Y0GNB2L1chr5

180666066

-MAP4chr3

47913590

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000511566GNB2L1chr5180666066-ENST00000383737MAP4chr347913590-3986716801645521
ENST00000511566GNB2L1chr5180666066-ENST00000395734MAP4chr347913590-3898716801801573
ENST00000511566GNB2L1chr5180666066-ENST00000426837MAP4chr347913590-3791716801852590
ENST00000511566GNB2L1chr5180666066-ENST00000360240MAP4chr347913590-3017716801852590
ENST00000376817GNB2L1chr5180666066-ENST00000383737MAP4chr347913590-387760771536509
ENST00000376817GNB2L1chr5180666066-ENST00000395734MAP4chr347913590-378960771692561
ENST00000376817GNB2L1chr5180666066-ENST00000426837MAP4chr347913590-368260771743578
ENST00000376817GNB2L1chr5180666066-ENST00000360240MAP4chr347913590-290860771743578
ENST00000512805GNB2L1chr5180666066-ENST00000383737MAP4chr347913590-431510451751974599
ENST00000512805GNB2L1chr5180666066-ENST00000395734MAP4chr347913590-422710451752130651
ENST00000512805GNB2L1chr5180666066-ENST00000426837MAP4chr347913590-412010451752181668
ENST00000512805GNB2L1chr5180666066-ENST00000360240MAP4chr347913590-334610451752181668
ENST00000511900GNB2L1chr5180666066-ENST00000383737MAP4chr347913590-3842572801501473
ENST00000511900GNB2L1chr5180666066-ENST00000395734MAP4chr347913590-3754572801657525
ENST00000511900GNB2L1chr5180666066-ENST00000426837MAP4chr347913590-3647572801708542
ENST00000511900GNB2L1chr5180666066-ENST00000360240MAP4chr347913590-2873572801708542

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000511566ENST00000383737GNB2L1chr5180666066-MAP4chr347913590-0.010430130.9895699
ENST00000511566ENST00000395734GNB2L1chr5180666066-MAP4chr347913590-0.0064479860.99355197
ENST00000511566ENST00000426837GNB2L1chr5180666066-MAP4chr347913590-0.0069762880.99302375
ENST00000511566ENST00000360240GNB2L1chr5180666066-MAP4chr347913590-0.0058402880.9941597
ENST00000376817ENST00000383737GNB2L1chr5180666066-MAP4chr347913590-0.0097559860.9902441
ENST00000376817ENST00000395734GNB2L1chr5180666066-MAP4chr347913590-0.0060539780.993946
ENST00000376817ENST00000426837GNB2L1chr5180666066-MAP4chr347913590-0.0068375280.9931625
ENST00000376817ENST00000360240GNB2L1chr5180666066-MAP4chr347913590-0.0056829370.9943171
ENST00000512805ENST00000383737GNB2L1chr5180666066-MAP4chr347913590-0.0160044520.9839955
ENST00000512805ENST00000395734GNB2L1chr5180666066-MAP4chr347913590-0.0099903630.9900096
ENST00000512805ENST00000426837GNB2L1chr5180666066-MAP4chr347913590-0.0101606420.9898393
ENST00000512805ENST00000360240GNB2L1chr5180666066-MAP4chr347913590-0.0083369140.9916631
ENST00000511900ENST00000383737GNB2L1chr5180666066-MAP4chr347913590-0.0145419190.985458
ENST00000511900ENST00000395734GNB2L1chr5180666066-MAP4chr347913590-0.0102121630.9897878
ENST00000511900ENST00000426837GNB2L1chr5180666066-MAP4chr347913590-0.0108805990.9891194
ENST00000511900ENST00000360240GNB2L1chr5180666066-MAP4chr347913590-0.009580180.9904198

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>33710_33710_1_GNB2L1-MAP4_GNB2L1_chr5_180666066_ENST00000376817_MAP4_chr3_47913590_ENST00000360240_length(amino acids)=578AA_BP=200
MQGGGRRGCGASFSKPSSAILVAAATHALAAAMTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRGSWDGTLRLWDLTTGTTTRRFV
GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHT
GYLNTVTVSPDGSLCASGGKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPA
EVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKN
VRSKVGSTENIKHQPGGGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQKQPAGKVQIVSKKVSYSHIQSKCGSKDNIKHVPGGGNVQ
IQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGSEAPLCPGPPAGEEPAISEAAP

--------------------------------------------------------------

>33710_33710_2_GNB2L1-MAP4_GNB2L1_chr5_180666066_ENST00000376817_MAP4_chr3_47913590_ENST00000383737_length(amino acids)=509AA_BP=200
MQGGGRRGCGASFSKPSSAILVAAATHALAAAMTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRGSWDGTLRLWDLTTGTTTRRFV
GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHT
GYLNTVTVSPDGSLCASGGKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPA
EVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKN
VRSKVGSTENIKHQPGGGRVQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGS

--------------------------------------------------------------

>33710_33710_3_GNB2L1-MAP4_GNB2L1_chr5_180666066_ENST00000376817_MAP4_chr3_47913590_ENST00000395734_length(amino acids)=561AA_BP=200
MQGGGRRGCGASFSKPSSAILVAAATHALAAAMTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRGSWDGTLRLWDLTTGTTTRRFV
GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHT
GYLNTVTVSPDGSLCASGGKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPA
EVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKN
VRSKVGSTENIKHQPGGGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQKQPAGKVQIVSKKVSYSHIQSKCGSKDNIKHVPGGGNVQ
IQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKIETYRLTFRANARARTDHGADIVSRPP

--------------------------------------------------------------

>33710_33710_4_GNB2L1-MAP4_GNB2L1_chr5_180666066_ENST00000376817_MAP4_chr3_47913590_ENST00000426837_length(amino acids)=578AA_BP=200
MQGGGRRGCGASFSKPSSAILVAAATHALAAAMTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRGSWDGTLRLWDLTTGTTTRRFV
GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHT
GYLNTVTVSPDGSLCASGGKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPA
EVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKN
VRSKVGSTENIKHQPGGGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQKQPAGKVQIVSKKVSYSHIQSKCGSKDNIKHVPGGGNVQ
IQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGSEAPLCPGPPAGEEPAISEAAP

--------------------------------------------------------------

>33710_33710_5_GNB2L1-MAP4_GNB2L1_chr5_180666066_ENST00000511566_MAP4_chr3_47913590_ENST00000360240_length(amino acids)=590AA_BP=212
MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW
DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA
NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPK
KPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSR
LATNTSAPDLKNVRSKVGSTENIKHQPGGGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQKQPAGKVQIVSKKVSYSHIQSKCGSKD
NIKHVPGGGNVQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGSEAPLCPGPP

--------------------------------------------------------------

>33710_33710_6_GNB2L1-MAP4_GNB2L1_chr5_180666066_ENST00000511566_MAP4_chr3_47913590_ENST00000383737_length(amino acids)=521AA_BP=212
MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW
DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA
NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPK
KPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSR
LATNTSAPDLKNVRSKVGSTENIKHQPGGGRVQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLP

--------------------------------------------------------------

>33710_33710_7_GNB2L1-MAP4_GNB2L1_chr5_180666066_ENST00000511566_MAP4_chr3_47913590_ENST00000395734_length(amino acids)=573AA_BP=212
MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW
DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA
NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPK
KPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSR
LATNTSAPDLKNVRSKVGSTENIKHQPGGGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQKQPAGKVQIVSKKVSYSHIQSKCGSKD
NIKHVPGGGNVQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKIETYRLTFRANARAR

--------------------------------------------------------------

>33710_33710_8_GNB2L1-MAP4_GNB2L1_chr5_180666066_ENST00000511566_MAP4_chr3_47913590_ENST00000426837_length(amino acids)=590AA_BP=212
MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW
DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA
NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPK
KPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSR
LATNTSAPDLKNVRSKVGSTENIKHQPGGGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQKQPAGKVQIVSKKVSYSHIQSKCGSKD
NIKHVPGGGNVQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGSEAPLCPGPP

--------------------------------------------------------------

>33710_33710_9_GNB2L1-MAP4_GNB2L1_chr5_180666066_ENST00000511900_MAP4_chr3_47913590_ENST00000360240_length(amino acids)=542AA_BP=164
MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW
DLTTQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKPIADAKAPEKRASPSK
PASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAP
AAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVGSTENIKHQPGGGRAKVEKKTEAAATTRKPE
SNAVTKTAGPIASAQKQPAGKVQIVSKKVSYSHIQSKCGSKDNIKHVPGGGNVQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQK
LNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGSEAPLCPGPPAGEEPAISEAAPEAGAPTSASGLNGHPTLSGGGDQREAQTLDSQIQET

--------------------------------------------------------------

>33710_33710_10_GNB2L1-MAP4_GNB2L1_chr5_180666066_ENST00000511900_MAP4_chr3_47913590_ENST00000383737_length(amino acids)=473AA_BP=164
MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW
DLTTQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKPIADAKAPEKRASPSK
PASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAP
AAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVGSTENIKHQPGGGRVQIQNKKVDISKVSSKC
GSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGSEAPLCPGPPAGEEPAISEAAPEAGAPTSASGLNGHP

--------------------------------------------------------------

>33710_33710_11_GNB2L1-MAP4_GNB2L1_chr5_180666066_ENST00000511900_MAP4_chr3_47913590_ENST00000395734_length(amino acids)=525AA_BP=164
MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW
DLTTQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKPIADAKAPEKRASPSK
PASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAP
AAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVGSTENIKHQPGGGRAKVEKKTEAAATTRKPE
SNAVTKTAGPIASAQKQPAGKVQIVSKKVSYSHIQSKCGSKDNIKHVPGGGNVQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQK

--------------------------------------------------------------

>33710_33710_12_GNB2L1-MAP4_GNB2L1_chr5_180666066_ENST00000511900_MAP4_chr3_47913590_ENST00000426837_length(amino acids)=542AA_BP=164
MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW
DLTTQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKPIADAKAPEKRASPSK
PASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAP
AAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVGSTENIKHQPGGGRAKVEKKTEAAATTRKPE
SNAVTKTAGPIASAQKQPAGKVQIVSKKVSYSHIQSKCGSKDNIKHVPGGGNVQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQK
LNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGSEAPLCPGPPAGEEPAISEAAPEAGAPTSASGLNGHPTLSGGGDQREAQTLDSQIQET

--------------------------------------------------------------

>33710_33710_13_GNB2L1-MAP4_GNB2L1_chr5_180666066_ENST00000512805_MAP4_chr3_47913590_ENST00000360240_length(amino acids)=668AA_BP=290
MPCNFPLPFALHGAAILSRNVSWGSPFCMVERVFPVPAGGFSLSLSLQGGGRRGCGASFSKPSSAILVAAATHALAAAMTEQMTLRGTLK
GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV
GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHT
GYLNTVTVSPDGSLCASGGKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPA
EVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKN
VRSKVGSTENIKHQPGGGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQKQPAGKVQIVSKKVSYSHIQSKCGSKDNIKHVPGGGNVQ
IQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGSEAPLCPGPPAGEEPAISEAAP

--------------------------------------------------------------

>33710_33710_14_GNB2L1-MAP4_GNB2L1_chr5_180666066_ENST00000512805_MAP4_chr3_47913590_ENST00000383737_length(amino acids)=599AA_BP=290
MPCNFPLPFALHGAAILSRNVSWGSPFCMVERVFPVPAGGFSLSLSLQGGGRRGCGASFSKPSSAILVAAATHALAAAMTEQMTLRGTLK
GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV
GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHT
GYLNTVTVSPDGSLCASGGKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPA
EVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKN
VRSKVGSTENIKHQPGGGRVQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGS

--------------------------------------------------------------

>33710_33710_15_GNB2L1-MAP4_GNB2L1_chr5_180666066_ENST00000512805_MAP4_chr3_47913590_ENST00000395734_length(amino acids)=651AA_BP=290
MPCNFPLPFALHGAAILSRNVSWGSPFCMVERVFPVPAGGFSLSLSLQGGGRRGCGASFSKPSSAILVAAATHALAAAMTEQMTLRGTLK
GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV
GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHT
GYLNTVTVSPDGSLCASGGKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPA
EVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKN
VRSKVGSTENIKHQPGGGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQKQPAGKVQIVSKKVSYSHIQSKCGSKDNIKHVPGGGNVQ
IQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKIETYRLTFRANARARTDHGADIVSRPP

--------------------------------------------------------------

>33710_33710_16_GNB2L1-MAP4_GNB2L1_chr5_180666066_ENST00000512805_MAP4_chr3_47913590_ENST00000426837_length(amino acids)=668AA_BP=290
MPCNFPLPFALHGAAILSRNVSWGSPFCMVERVFPVPAGGFSLSLSLQGGGRRGCGASFSKPSSAILVAAATHALAAAMTEQMTLRGTLK
GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV
GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHT
GYLNTVTVSPDGSLCASGGKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPA
EVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKN
VRSKVGSTENIKHQPGGGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQKQPAGKVQIVSKKVSYSHIQSKCGSKDNIKHVPGGGNVQ
IQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGSEAPLCPGPPAGEEPAISEAAP

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:180666066/chr3:47913590)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MAP4

Q9Y4K4

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269|PubMed:9038372}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGNB2L1chr5:180666066chr3:47913590ENST00000512805-58103_133212.0318.0RepeatNote=WD 3
HgeneGNB2L1chr5:180666066chr3:47913590ENST00000512805-5813_44212.0318.0RepeatNote=WD 1
HgeneGNB2L1chr5:180666066chr3:47913590ENST00000512805-58146_178212.0318.0RepeatNote=WD 4
HgeneGNB2L1chr5:180666066chr3:47913590ENST00000512805-5861_91212.0318.0RepeatNote=WD 2
TgeneMAP4chr5:180666066chr3:47913590ENST0000043426704248_5450100.0RegionNote=17 X 14 AA tandem repeats
TgeneMAP4chr5:180666066chr3:47913590ENST0000043935604248_5450100.0RegionNote=17 X 14 AA tandem repeats
TgeneMAP4chr5:180666066chr3:47913590ENST000003602409191023_1053774.01153.0RepeatNote=Tau/MAP 3
TgeneMAP4chr5:180666066chr3:47913590ENST000003602409191054_1085774.01153.0RepeatNote=Tau/MAP 4
TgeneMAP4chr5:180666066chr3:47913590ENST00000360240919923_953774.01153.0RepeatNote=Tau/MAP 1
TgeneMAP4chr5:180666066chr3:47913590ENST00000360240919992_1022774.01153.0RepeatNote=Tau/MAP 2
TgeneMAP4chr5:180666066chr3:47913590ENST000003957349181023_1053774.01136.0RepeatNote=Tau/MAP 3
TgeneMAP4chr5:180666066chr3:47913590ENST000003957349181054_1085774.01136.0RepeatNote=Tau/MAP 4
TgeneMAP4chr5:180666066chr3:47913590ENST00000395734918923_953774.01136.0RepeatNote=Tau/MAP 1
TgeneMAP4chr5:180666066chr3:47913590ENST00000395734918992_1022774.01136.0RepeatNote=Tau/MAP 2
TgeneMAP4chr5:180666066chr3:47913590ENST00000434267041023_10530100.0RepeatNote=Tau/MAP 3
TgeneMAP4chr5:180666066chr3:47913590ENST00000434267041054_10850100.0RepeatNote=Tau/MAP 4
TgeneMAP4chr5:180666066chr3:47913590ENST0000043426704248_2610100.0RepeatNote=1
TgeneMAP4chr5:180666066chr3:47913590ENST0000043426704262_2750100.0RepeatNote=2
TgeneMAP4chr5:180666066chr3:47913590ENST0000043426704276_2890100.0RepeatNote=3
TgeneMAP4chr5:180666066chr3:47913590ENST0000043426704290_3030100.0RepeatNote=4
TgeneMAP4chr5:180666066chr3:47913590ENST0000043426704304_3170100.0RepeatNote=5
TgeneMAP4chr5:180666066chr3:47913590ENST0000043426704318_3310100.0RepeatNote=6
TgeneMAP4chr5:180666066chr3:47913590ENST0000043426704332_3450100.0RepeatNote=7
TgeneMAP4chr5:180666066chr3:47913590ENST0000043426704346_3510100.0RepeatNote=8%3B truncated
TgeneMAP4chr5:180666066chr3:47913590ENST0000043426704352_3770100.0RepeatNote=26 residues 1
TgeneMAP4chr5:180666066chr3:47913590ENST0000043426704378_4030100.0RepeatNote=26 residues 2
TgeneMAP4chr5:180666066chr3:47913590ENST0000043426704408_4210100.0RepeatNote=9
TgeneMAP4chr5:180666066chr3:47913590ENST0000043426704422_4330100.0RepeatNote=10
TgeneMAP4chr5:180666066chr3:47913590ENST0000043426704434_4470100.0RepeatNote=11
TgeneMAP4chr5:180666066chr3:47913590ENST0000043426704448_4610100.0RepeatNote=12
TgeneMAP4chr5:180666066chr3:47913590ENST0000043426704462_4750100.0RepeatNote=13
TgeneMAP4chr5:180666066chr3:47913590ENST0000043426704476_4890100.0RepeatNote=14
TgeneMAP4chr5:180666066chr3:47913590ENST0000043426704490_5030100.0RepeatNote=15
TgeneMAP4chr5:180666066chr3:47913590ENST0000043426704504_5170100.0RepeatNote=16
TgeneMAP4chr5:180666066chr3:47913590ENST0000043426704532_5450100.0RepeatNote=17
TgeneMAP4chr5:180666066chr3:47913590ENST0000043426704923_9530100.0RepeatNote=Tau/MAP 1
TgeneMAP4chr5:180666066chr3:47913590ENST0000043426704992_10220100.0RepeatNote=Tau/MAP 2
TgeneMAP4chr5:180666066chr3:47913590ENST00000439356041023_10530100.0RepeatNote=Tau/MAP 3
TgeneMAP4chr5:180666066chr3:47913590ENST00000439356041054_10850100.0RepeatNote=Tau/MAP 4
TgeneMAP4chr5:180666066chr3:47913590ENST0000043935604248_2610100.0RepeatNote=1
TgeneMAP4chr5:180666066chr3:47913590ENST0000043935604262_2750100.0RepeatNote=2
TgeneMAP4chr5:180666066chr3:47913590ENST0000043935604276_2890100.0RepeatNote=3
TgeneMAP4chr5:180666066chr3:47913590ENST0000043935604290_3030100.0RepeatNote=4
TgeneMAP4chr5:180666066chr3:47913590ENST0000043935604304_3170100.0RepeatNote=5
TgeneMAP4chr5:180666066chr3:47913590ENST0000043935604318_3310100.0RepeatNote=6
TgeneMAP4chr5:180666066chr3:47913590ENST0000043935604332_3450100.0RepeatNote=7
TgeneMAP4chr5:180666066chr3:47913590ENST0000043935604346_3510100.0RepeatNote=8%3B truncated
TgeneMAP4chr5:180666066chr3:47913590ENST0000043935604352_3770100.0RepeatNote=26 residues 1
TgeneMAP4chr5:180666066chr3:47913590ENST0000043935604378_4030100.0RepeatNote=26 residues 2
TgeneMAP4chr5:180666066chr3:47913590ENST0000043935604408_4210100.0RepeatNote=9
TgeneMAP4chr5:180666066chr3:47913590ENST0000043935604422_4330100.0RepeatNote=10
TgeneMAP4chr5:180666066chr3:47913590ENST0000043935604434_4470100.0RepeatNote=11
TgeneMAP4chr5:180666066chr3:47913590ENST0000043935604448_4610100.0RepeatNote=12
TgeneMAP4chr5:180666066chr3:47913590ENST0000043935604462_4750100.0RepeatNote=13
TgeneMAP4chr5:180666066chr3:47913590ENST0000043935604476_4890100.0RepeatNote=14
TgeneMAP4chr5:180666066chr3:47913590ENST0000043935604490_5030100.0RepeatNote=15
TgeneMAP4chr5:180666066chr3:47913590ENST0000043935604504_5170100.0RepeatNote=16
TgeneMAP4chr5:180666066chr3:47913590ENST0000043935604532_5450100.0RepeatNote=17
TgeneMAP4chr5:180666066chr3:47913590ENST0000043935604923_9530100.0RepeatNote=Tau/MAP 1
TgeneMAP4chr5:180666066chr3:47913590ENST0000043935604992_10220100.0RepeatNote=Tau/MAP 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGNB2L1chr5:180666066chr3:47913590ENST00000512805-58190_220212.0318.0RepeatNote=WD 5
HgeneGNB2L1chr5:180666066chr3:47913590ENST00000512805-58231_260212.0318.0RepeatNote=WD 6
HgeneGNB2L1chr5:180666066chr3:47913590ENST00000512805-58281_311212.0318.0RepeatNote=WD 7
TgeneMAP4chr5:180666066chr3:47913590ENST00000360240919248_545774.01153.0RegionNote=17 X 14 AA tandem repeats
TgeneMAP4chr5:180666066chr3:47913590ENST00000395734918248_545774.01136.0RegionNote=17 X 14 AA tandem repeats
TgeneMAP4chr5:180666066chr3:47913590ENST00000360240919248_261774.01153.0RepeatNote=1
TgeneMAP4chr5:180666066chr3:47913590ENST00000360240919262_275774.01153.0RepeatNote=2
TgeneMAP4chr5:180666066chr3:47913590ENST00000360240919276_289774.01153.0RepeatNote=3
TgeneMAP4chr5:180666066chr3:47913590ENST00000360240919290_303774.01153.0RepeatNote=4
TgeneMAP4chr5:180666066chr3:47913590ENST00000360240919304_317774.01153.0RepeatNote=5
TgeneMAP4chr5:180666066chr3:47913590ENST00000360240919318_331774.01153.0RepeatNote=6
TgeneMAP4chr5:180666066chr3:47913590ENST00000360240919332_345774.01153.0RepeatNote=7
TgeneMAP4chr5:180666066chr3:47913590ENST00000360240919346_351774.01153.0RepeatNote=8%3B truncated
TgeneMAP4chr5:180666066chr3:47913590ENST00000360240919352_377774.01153.0RepeatNote=26 residues 1
TgeneMAP4chr5:180666066chr3:47913590ENST00000360240919378_403774.01153.0RepeatNote=26 residues 2
TgeneMAP4chr5:180666066chr3:47913590ENST00000360240919408_421774.01153.0RepeatNote=9
TgeneMAP4chr5:180666066chr3:47913590ENST00000360240919422_433774.01153.0RepeatNote=10
TgeneMAP4chr5:180666066chr3:47913590ENST00000360240919434_447774.01153.0RepeatNote=11
TgeneMAP4chr5:180666066chr3:47913590ENST00000360240919448_461774.01153.0RepeatNote=12
TgeneMAP4chr5:180666066chr3:47913590ENST00000360240919462_475774.01153.0RepeatNote=13
TgeneMAP4chr5:180666066chr3:47913590ENST00000360240919476_489774.01153.0RepeatNote=14
TgeneMAP4chr5:180666066chr3:47913590ENST00000360240919490_503774.01153.0RepeatNote=15
TgeneMAP4chr5:180666066chr3:47913590ENST00000360240919504_517774.01153.0RepeatNote=16
TgeneMAP4chr5:180666066chr3:47913590ENST00000360240919532_545774.01153.0RepeatNote=17
TgeneMAP4chr5:180666066chr3:47913590ENST00000395734918248_261774.01136.0RepeatNote=1
TgeneMAP4chr5:180666066chr3:47913590ENST00000395734918262_275774.01136.0RepeatNote=2
TgeneMAP4chr5:180666066chr3:47913590ENST00000395734918276_289774.01136.0RepeatNote=3
TgeneMAP4chr5:180666066chr3:47913590ENST00000395734918290_303774.01136.0RepeatNote=4
TgeneMAP4chr5:180666066chr3:47913590ENST00000395734918304_317774.01136.0RepeatNote=5
TgeneMAP4chr5:180666066chr3:47913590ENST00000395734918318_331774.01136.0RepeatNote=6
TgeneMAP4chr5:180666066chr3:47913590ENST00000395734918332_345774.01136.0RepeatNote=7
TgeneMAP4chr5:180666066chr3:47913590ENST00000395734918346_351774.01136.0RepeatNote=8%3B truncated
TgeneMAP4chr5:180666066chr3:47913590ENST00000395734918352_377774.01136.0RepeatNote=26 residues 1
TgeneMAP4chr5:180666066chr3:47913590ENST00000395734918378_403774.01136.0RepeatNote=26 residues 2
TgeneMAP4chr5:180666066chr3:47913590ENST00000395734918408_421774.01136.0RepeatNote=9
TgeneMAP4chr5:180666066chr3:47913590ENST00000395734918422_433774.01136.0RepeatNote=10
TgeneMAP4chr5:180666066chr3:47913590ENST00000395734918434_447774.01136.0RepeatNote=11
TgeneMAP4chr5:180666066chr3:47913590ENST00000395734918448_461774.01136.0RepeatNote=12
TgeneMAP4chr5:180666066chr3:47913590ENST00000395734918462_475774.01136.0RepeatNote=13
TgeneMAP4chr5:180666066chr3:47913590ENST00000395734918476_489774.01136.0RepeatNote=14
TgeneMAP4chr5:180666066chr3:47913590ENST00000395734918490_503774.01136.0RepeatNote=15
TgeneMAP4chr5:180666066chr3:47913590ENST00000395734918504_517774.01136.0RepeatNote=16
TgeneMAP4chr5:180666066chr3:47913590ENST00000395734918532_545774.01136.0RepeatNote=17


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
GNB2L1
MAP4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to GNB2L1-MAP4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to GNB2L1-MAP4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource