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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:GPHN-DCAF5

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: GPHN-DCAF5
FusionPDB ID: 34243
FusionGDB2.0 ID: 34243
HgeneTgene
Gene symbol

GPHN

DCAF5

Gene ID

10243

8816

Gene namegephyrinDDB1 and CUL4 associated factor 5
SynonymsGEPH|GPH|GPHRYN|HKPX1|MOCODCBCRG2|BCRP2|D14S1461E|WDR22
Cytomap

14q23.3-q24.1

14q24.1

Type of geneprotein-codingprotein-coding
DescriptiongephyrinDDB1- and CUL4-associated factor 5WD repeat-containing protein 22breakpoint cluster region protein, uterine leiomyoma, 2
Modification date2020031320200313
UniProtAcc

Q9NQX3

Q96JK2

Ensembl transtripts involved in fusion geneENST idsENST00000305960, ENST00000315266, 
ENST00000459628, ENST00000478722, 
ENST00000543237, ENST00000544752, 
ENST00000553293, ENST00000341516, 
ENST00000389997, ENST00000554215, 
ENST00000556847, ENST00000557386, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score38 X 33 X 10=1254010 X 10 X 6=600
# samples 4011
** MAII scorelog2(40/12540*10)=-4.97039353791468
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/600*10)=-2.44745897697122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: GPHN [Title/Abstract] AND DCAF5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GPHN(67147903)-DCAF5(69558604), # samples:3
Anticipated loss of major functional domain due to fusion event.GPHN-DCAF5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GPHN-DCAF5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGPHN

GO:0032324

molybdopterin cofactor biosynthetic process

26613940

HgeneGPHN

GO:0097112

gamma-aminobutyric acid receptor clustering

26613940


check buttonFusion gene breakpoints across GPHN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DCAF5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-85-A53L-01AGPHNchr14

67147903

-DCAF5chr14

69558604

-
ChimerDB4LUSCTCGA-85-A53L-01AGPHNchr14

67147903

+DCAF5chr14

69558604

-
ChimerDB4LUSCTCGA-85-A53LGPHNchr14

67147903

+DCAF5chr14

69558604

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000315266GPHNchr1467147903+ENST00000341516DCAF5chr1469558604-6404126410253427800
ENST00000315266GPHNchr1467147903+ENST00000554215DCAF5chr1469558604-5430126410253427800
ENST00000315266GPHNchr1467147903+ENST00000556847DCAF5chr1469558604-3483126410253427800
ENST00000315266GPHNchr1467147903+ENST00000557386DCAF5chr1469558604-3460126410253427800
ENST00000315266GPHNchr1467147903+ENST00000389997DCAF5chr1469558604-343112641420749223
ENST00000478722GPHNchr1467147903+ENST00000341516DCAF5chr1469558604-6404126410253427800
ENST00000478722GPHNchr1467147903+ENST00000554215DCAF5chr1469558604-5430126410253427800
ENST00000478722GPHNchr1467147903+ENST00000556847DCAF5chr1469558604-3483126410253427800
ENST00000478722GPHNchr1467147903+ENST00000557386DCAF5chr1469558604-3460126410253427800
ENST00000478722GPHNchr1467147903+ENST00000389997DCAF5chr1469558604-343112641420749223
ENST00000459628GPHNchr1467147903+ENST00000341516DCAF5chr1469558604-56735332942696800
ENST00000459628GPHNchr1467147903+ENST00000554215DCAF5chr1469558604-46995332942696800
ENST00000459628GPHNchr1467147903+ENST00000556847DCAF5chr1469558604-27525332942696800
ENST00000459628GPHNchr1467147903+ENST00000557386DCAF5chr1469558604-27295332942696800
ENST00000459628GPHNchr1467147903+ENST00000389997DCAF5chr1469558604-270053368918223
ENST00000543237GPHNchr1467147903+ENST00000341516DCAF5chr1469558604-5307167152330771
ENST00000543237GPHNchr1467147903+ENST00000554215DCAF5chr1469558604-4333167152330771
ENST00000543237GPHNchr1467147903+ENST00000556847DCAF5chr1469558604-2386167152330771
ENST00000543237GPHNchr1467147903+ENST00000557386DCAF5chr1469558604-2363167152330771
ENST00000543237GPHNchr1467147903+ENST00000389997DCAF5chr1469558604-233416715482155
ENST00000305960GPHNchr1467147903+ENST00000341516DCAF5chr1469558604-529815862321771
ENST00000305960GPHNchr1467147903+ENST00000554215DCAF5chr1469558604-432415862321771
ENST00000305960GPHNchr1467147903+ENST00000556847DCAF5chr1469558604-237715862321771
ENST00000305960GPHNchr1467147903+ENST00000557386DCAF5chr1469558604-235415862321771
ENST00000305960GPHNchr1467147903+ENST00000389997DCAF5chr1469558604-23251586473155

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000315266ENST00000341516GPHNchr1467147903+DCAF5chr1469558604-0.0013038410.99869615
ENST00000315266ENST00000554215GPHNchr1467147903+DCAF5chr1469558604-0.0020602330.99793977
ENST00000315266ENST00000556847GPHNchr1467147903+DCAF5chr1469558604-0.0098351030.99016494
ENST00000315266ENST00000557386GPHNchr1467147903+DCAF5chr1469558604-0.0105321560.9894678
ENST00000315266ENST00000389997GPHNchr1467147903+DCAF5chr1469558604-0.0076647210.99233526
ENST00000478722ENST00000341516GPHNchr1467147903+DCAF5chr1469558604-0.0013038410.99869615
ENST00000478722ENST00000554215GPHNchr1467147903+DCAF5chr1469558604-0.0020602330.99793977
ENST00000478722ENST00000556847GPHNchr1467147903+DCAF5chr1469558604-0.0098351030.99016494
ENST00000478722ENST00000557386GPHNchr1467147903+DCAF5chr1469558604-0.0105321560.9894678
ENST00000478722ENST00000389997GPHNchr1467147903+DCAF5chr1469558604-0.0076647210.99233526
ENST00000459628ENST00000341516GPHNchr1467147903+DCAF5chr1469558604-0.0008759880.999124
ENST00000459628ENST00000554215GPHNchr1467147903+DCAF5chr1469558604-0.0012854270.99871457
ENST00000459628ENST00000556847GPHNchr1467147903+DCAF5chr1469558604-0.00745180.99254817
ENST00000459628ENST00000557386GPHNchr1467147903+DCAF5chr1469558604-0.0079715820.9920284
ENST00000459628ENST00000389997GPHNchr1467147903+DCAF5chr1469558604-0.0183053220.98169476
ENST00000543237ENST00000341516GPHNchr1467147903+DCAF5chr1469558604-0.0008199480.99918
ENST00000543237ENST00000554215GPHNchr1467147903+DCAF5chr1469558604-0.001210140.99878985
ENST00000543237ENST00000556847GPHNchr1467147903+DCAF5chr1469558604-0.0077939030.99220604
ENST00000543237ENST00000557386GPHNchr1467147903+DCAF5chr1469558604-0.0083675680.9916324
ENST00000543237ENST00000389997GPHNchr1467147903+DCAF5chr1469558604-0.0208770860.9791229
ENST00000305960ENST00000341516GPHNchr1467147903+DCAF5chr1469558604-0.0008282760.99917173
ENST00000305960ENST00000554215GPHNchr1467147903+DCAF5chr1469558604-0.0012336890.9987663
ENST00000305960ENST00000556847GPHNchr1467147903+DCAF5chr1469558604-0.0079415660.99205846
ENST00000305960ENST00000557386GPHNchr1467147903+DCAF5chr1469558604-0.0085238350.9914761
ENST00000305960ENST00000389997GPHNchr1467147903+DCAF5chr1469558604-0.0086356130.99136436

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>34243_34243_1_GPHN-DCAF5_GPHN_chr14_67147903_ENST00000305960_DCAF5_chr14_69558604_ENST00000341516_length(amino acids)=771AA_BP=48
MGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSFSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYD
IHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVVNGAFMVLKGHRSIVNQVRFNPHTYMICSS
GVEKIIKIWSPYKQPGCTGDLDGRIEDDSRCLYTHEEYISLVLNSGSGLSHDYANQSVQEDPRMMAFFDSLVRREIEGWSSDSDSDLSES
TILQLHAGVSERSGYTDSESSASLPRSPPPTVDESADNAFHLGPLRVTTTNTVASTPPTPTCEDAASRQQRLSALRRYQDKRLLALSNES
DSEENVCEVELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAMRRRQKTTREDKPSAPIKPTNTYIGEDNYDYPQIK
VDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKIYKAYKWLRYSYISYSNNKDGETSLVTGEADEGRAGTSHKDNPAPSSSKEAC
LNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVEHPFETKKLNGKALSSRAEEPPSPPVPKAS
GSTLNSGSGNCPRTQSDDSEERSLETICANHNNGRLHPRPPHPHNNGQNLGELEVVAYSSPGHSDTDRDNSSLTGTLLHKDCCGSEMACE

--------------------------------------------------------------

>34243_34243_2_GPHN-DCAF5_GPHN_chr14_67147903_ENST00000305960_DCAF5_chr14_69558604_ENST00000389997_length(amino acids)=155AA_BP=48
MGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSFSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYD

--------------------------------------------------------------

>34243_34243_3_GPHN-DCAF5_GPHN_chr14_67147903_ENST00000305960_DCAF5_chr14_69558604_ENST00000554215_length(amino acids)=771AA_BP=48
MGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSFSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYD
IHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVVNGAFMVLKGHRSIVNQVRFNPHTYMICSS
GVEKIIKIWSPYKQPGCTGDLDGRIEDDSRCLYTHEEYISLVLNSGSGLSHDYANQSVQEDPRMMAFFDSLVRREIEGWSSDSDSDLSES
TILQLHAGVSERSGYTDSESSASLPRSPPPTVDESADNAFHLGPLRVTTTNTVASTPPTPTCEDAASRQQRLSALRRYQDKRLLALSNES
DSEENVCEVELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAMRRRQKTTREDKPSAPIKPTNTYIGEDNYDYPQIK
VDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKIYKAYKWLRYSYISYSNNKDGETSLVTGEADEGRAGTSHKDNPAPSSSKEAC
LNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVEHPFETKKLNGKALSSRAEEPPSPPVPKAS
GSTLNSGSGNCPRTQSDDSEERSLETICANHNNGRLHPRPPHPHNNGQNLGELEVVAYSSPGHSDTDRDNSSLTGTLLHKDCCGSEMACE

--------------------------------------------------------------

>34243_34243_4_GPHN-DCAF5_GPHN_chr14_67147903_ENST00000305960_DCAF5_chr14_69558604_ENST00000556847_length(amino acids)=771AA_BP=48
MGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSFSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYD
IHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVVNGAFMVLKGHRSIVNQVRFNPHTYMICSS
GVEKIIKIWSPYKQPGCTGDLDGRIEDDSRCLYTHEEYISLVLNSGSGLSHDYANQSVQEDPRMMAFFDSLVRREIEGWSSDSDSDLSES
TILQLHAGVSERSGYTDSESSASLPRSPPPTVDESADNAFHLGPLRVTTTNTVASTPPTPTCEDAASRQQRLSALRRYQDKRLLALSNES
DSEENVCEVELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAMRRRQKTTREDKPSAPIKPTNTYIGEDNYDYPQIK
VDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKIYKAYKWLRYSYISYSNNKDGETSLVTGEADEGRAGTSHKDNPAPSSSKEAC
LNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVEHPFETKKLNGKALSSRAEEPPSPPVPKAS
GSTLNSGSGNCPRTQSDDSEERSLETICANHNNGRLHPRPPHPHNNGQNLGELEVVAYSSPGHSDTDRDNSSLTGTLLHKDCCGSEMACE

--------------------------------------------------------------

>34243_34243_5_GPHN-DCAF5_GPHN_chr14_67147903_ENST00000305960_DCAF5_chr14_69558604_ENST00000557386_length(amino acids)=771AA_BP=48
MGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSFSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYD
IHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVVNGAFMVLKGHRSIVNQVRFNPHTYMICSS
GVEKIIKIWSPYKQPGCTGDLDGRIEDDSRCLYTHEEYISLVLNSGSGLSHDYANQSVQEDPRMMAFFDSLVRREIEGWSSDSDSDLSES
TILQLHAGVSERSGYTDSESSASLPRSPPPTVDESADNAFHLGPLRVTTTNTVASTPPTPTCEDAASRQQRLSALRRYQDKRLLALSNES
DSEENVCEVELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAMRRRQKTTREDKPSAPIKPTNTYIGEDNYDYPQIK
VDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKIYKAYKWLRYSYISYSNNKDGETSLVTGEADEGRAGTSHKDNPAPSSSKEAC
LNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVEHPFETKKLNGKALSSRAEEPPSPPVPKAS
GSTLNSGSGNCPRTQSDDSEERSLETICANHNNGRLHPRPPHPHNNGQNLGELEVVAYSSPGHSDTDRDNSSLTGTLLHKDCCGSEMACE

--------------------------------------------------------------

>34243_34243_6_GPHN-DCAF5_GPHN_chr14_67147903_ENST00000315266_DCAF5_chr14_69558604_ENST00000341516_length(amino acids)=800AA_BP=77
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSFSLLRYGGNLS
LQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVV
NGAFMVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWSPYKQPGCTGDLDGRIEDDSRCLYTHEEYISLVLNSGSGLSHDYANQSVQED
PRMMAFFDSLVRREIEGWSSDSDSDLSESTILQLHAGVSERSGYTDSESSASLPRSPPPTVDESADNAFHLGPLRVTTTNTVASTPPTPT
CEDAASRQQRLSALRRYQDKRLLALSNESDSEENVCEVELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAMRRRQK
TTREDKPSAPIKPTNTYIGEDNYDYPQIKVDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKIYKAYKWLRYSYISYSNNKDGET
SLVTGEADEGRAGTSHKDNPAPSSSKEACLNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVE
HPFETKKLNGKALSSRAEEPPSPPVPKASGSTLNSGSGNCPRTQSDDSEERSLETICANHNNGRLHPRPPHPHNNGQNLGELEVVAYSSP

--------------------------------------------------------------

>34243_34243_7_GPHN-DCAF5_GPHN_chr14_67147903_ENST00000315266_DCAF5_chr14_69558604_ENST00000389997_length(amino acids)=223AA_BP=1
MIVKLKHRQAGMDVIEHRGQASPQGQELGPVAVESYTHGTLEGQVSTIAQERKRRILYEIFEIYPTAVFCKIPEATITHCKDSDTDLMVV
VSKDHSLGRHVSQRSHRTDRSREKPEPGARGPGARSPRRARQLGSQRSARRAGKEGEATECTVACVGERPRRECAGPREGKESGRAAPSP

--------------------------------------------------------------

>34243_34243_8_GPHN-DCAF5_GPHN_chr14_67147903_ENST00000315266_DCAF5_chr14_69558604_ENST00000554215_length(amino acids)=800AA_BP=77
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSFSLLRYGGNLS
LQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVV
NGAFMVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWSPYKQPGCTGDLDGRIEDDSRCLYTHEEYISLVLNSGSGLSHDYANQSVQED
PRMMAFFDSLVRREIEGWSSDSDSDLSESTILQLHAGVSERSGYTDSESSASLPRSPPPTVDESADNAFHLGPLRVTTTNTVASTPPTPT
CEDAASRQQRLSALRRYQDKRLLALSNESDSEENVCEVELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAMRRRQK
TTREDKPSAPIKPTNTYIGEDNYDYPQIKVDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKIYKAYKWLRYSYISYSNNKDGET
SLVTGEADEGRAGTSHKDNPAPSSSKEACLNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVE
HPFETKKLNGKALSSRAEEPPSPPVPKASGSTLNSGSGNCPRTQSDDSEERSLETICANHNNGRLHPRPPHPHNNGQNLGELEVVAYSSP

--------------------------------------------------------------

>34243_34243_9_GPHN-DCAF5_GPHN_chr14_67147903_ENST00000315266_DCAF5_chr14_69558604_ENST00000556847_length(amino acids)=800AA_BP=77
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSFSLLRYGGNLS
LQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVV
NGAFMVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWSPYKQPGCTGDLDGRIEDDSRCLYTHEEYISLVLNSGSGLSHDYANQSVQED
PRMMAFFDSLVRREIEGWSSDSDSDLSESTILQLHAGVSERSGYTDSESSASLPRSPPPTVDESADNAFHLGPLRVTTTNTVASTPPTPT
CEDAASRQQRLSALRRYQDKRLLALSNESDSEENVCEVELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAMRRRQK
TTREDKPSAPIKPTNTYIGEDNYDYPQIKVDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKIYKAYKWLRYSYISYSNNKDGET
SLVTGEADEGRAGTSHKDNPAPSSSKEACLNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVE
HPFETKKLNGKALSSRAEEPPSPPVPKASGSTLNSGSGNCPRTQSDDSEERSLETICANHNNGRLHPRPPHPHNNGQNLGELEVVAYSSP

--------------------------------------------------------------

>34243_34243_10_GPHN-DCAF5_GPHN_chr14_67147903_ENST00000315266_DCAF5_chr14_69558604_ENST00000557386_length(amino acids)=800AA_BP=77
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSFSLLRYGGNLS
LQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVV
NGAFMVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWSPYKQPGCTGDLDGRIEDDSRCLYTHEEYISLVLNSGSGLSHDYANQSVQED
PRMMAFFDSLVRREIEGWSSDSDSDLSESTILQLHAGVSERSGYTDSESSASLPRSPPPTVDESADNAFHLGPLRVTTTNTVASTPPTPT
CEDAASRQQRLSALRRYQDKRLLALSNESDSEENVCEVELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAMRRRQK
TTREDKPSAPIKPTNTYIGEDNYDYPQIKVDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKIYKAYKWLRYSYISYSNNKDGET
SLVTGEADEGRAGTSHKDNPAPSSSKEACLNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVE
HPFETKKLNGKALSSRAEEPPSPPVPKASGSTLNSGSGNCPRTQSDDSEERSLETICANHNNGRLHPRPPHPHNNGQNLGELEVVAYSSP

--------------------------------------------------------------

>34243_34243_11_GPHN-DCAF5_GPHN_chr14_67147903_ENST00000459628_DCAF5_chr14_69558604_ENST00000341516_length(amino acids)=800AA_BP=77
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSFSLLRYGGNLS
LQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVV
NGAFMVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWSPYKQPGCTGDLDGRIEDDSRCLYTHEEYISLVLNSGSGLSHDYANQSVQED
PRMMAFFDSLVRREIEGWSSDSDSDLSESTILQLHAGVSERSGYTDSESSASLPRSPPPTVDESADNAFHLGPLRVTTTNTVASTPPTPT
CEDAASRQQRLSALRRYQDKRLLALSNESDSEENVCEVELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAMRRRQK
TTREDKPSAPIKPTNTYIGEDNYDYPQIKVDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKIYKAYKWLRYSYISYSNNKDGET
SLVTGEADEGRAGTSHKDNPAPSSSKEACLNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVE
HPFETKKLNGKALSSRAEEPPSPPVPKASGSTLNSGSGNCPRTQSDDSEERSLETICANHNNGRLHPRPPHPHNNGQNLGELEVVAYSSP

--------------------------------------------------------------

>34243_34243_12_GPHN-DCAF5_GPHN_chr14_67147903_ENST00000459628_DCAF5_chr14_69558604_ENST00000389997_length(amino acids)=223AA_BP=1
MIVKLKHRQAGMDVIEHRGQASPQGQELGPVAVESYTHGTLEGQVSTIAQERKRRILYEIFEIYPTAVFCKIPEATITHCKDSDTDLMVV
VSKDHSLGRHVSQRSHRTDRSREKPEPGARGPGARSPRRARQLGSQRSARRAGKEGEATECTVACVGERPRRECAGPREGKESGRAAPSP

--------------------------------------------------------------

>34243_34243_13_GPHN-DCAF5_GPHN_chr14_67147903_ENST00000459628_DCAF5_chr14_69558604_ENST00000554215_length(amino acids)=800AA_BP=77
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSFSLLRYGGNLS
LQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVV
NGAFMVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWSPYKQPGCTGDLDGRIEDDSRCLYTHEEYISLVLNSGSGLSHDYANQSVQED
PRMMAFFDSLVRREIEGWSSDSDSDLSESTILQLHAGVSERSGYTDSESSASLPRSPPPTVDESADNAFHLGPLRVTTTNTVASTPPTPT
CEDAASRQQRLSALRRYQDKRLLALSNESDSEENVCEVELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAMRRRQK
TTREDKPSAPIKPTNTYIGEDNYDYPQIKVDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKIYKAYKWLRYSYISYSNNKDGET
SLVTGEADEGRAGTSHKDNPAPSSSKEACLNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVE
HPFETKKLNGKALSSRAEEPPSPPVPKASGSTLNSGSGNCPRTQSDDSEERSLETICANHNNGRLHPRPPHPHNNGQNLGELEVVAYSSP

--------------------------------------------------------------

>34243_34243_14_GPHN-DCAF5_GPHN_chr14_67147903_ENST00000459628_DCAF5_chr14_69558604_ENST00000556847_length(amino acids)=800AA_BP=77
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSFSLLRYGGNLS
LQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVV
NGAFMVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWSPYKQPGCTGDLDGRIEDDSRCLYTHEEYISLVLNSGSGLSHDYANQSVQED
PRMMAFFDSLVRREIEGWSSDSDSDLSESTILQLHAGVSERSGYTDSESSASLPRSPPPTVDESADNAFHLGPLRVTTTNTVASTPPTPT
CEDAASRQQRLSALRRYQDKRLLALSNESDSEENVCEVELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAMRRRQK
TTREDKPSAPIKPTNTYIGEDNYDYPQIKVDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKIYKAYKWLRYSYISYSNNKDGET
SLVTGEADEGRAGTSHKDNPAPSSSKEACLNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVE
HPFETKKLNGKALSSRAEEPPSPPVPKASGSTLNSGSGNCPRTQSDDSEERSLETICANHNNGRLHPRPPHPHNNGQNLGELEVVAYSSP

--------------------------------------------------------------

>34243_34243_15_GPHN-DCAF5_GPHN_chr14_67147903_ENST00000459628_DCAF5_chr14_69558604_ENST00000557386_length(amino acids)=800AA_BP=77
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSFSLLRYGGNLS
LQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVV
NGAFMVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWSPYKQPGCTGDLDGRIEDDSRCLYTHEEYISLVLNSGSGLSHDYANQSVQED
PRMMAFFDSLVRREIEGWSSDSDSDLSESTILQLHAGVSERSGYTDSESSASLPRSPPPTVDESADNAFHLGPLRVTTTNTVASTPPTPT
CEDAASRQQRLSALRRYQDKRLLALSNESDSEENVCEVELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAMRRRQK
TTREDKPSAPIKPTNTYIGEDNYDYPQIKVDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKIYKAYKWLRYSYISYSNNKDGET
SLVTGEADEGRAGTSHKDNPAPSSSKEACLNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVE
HPFETKKLNGKALSSRAEEPPSPPVPKASGSTLNSGSGNCPRTQSDDSEERSLETICANHNNGRLHPRPPHPHNNGQNLGELEVVAYSSP

--------------------------------------------------------------

>34243_34243_16_GPHN-DCAF5_GPHN_chr14_67147903_ENST00000478722_DCAF5_chr14_69558604_ENST00000341516_length(amino acids)=800AA_BP=77
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSFSLLRYGGNLS
LQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVV
NGAFMVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWSPYKQPGCTGDLDGRIEDDSRCLYTHEEYISLVLNSGSGLSHDYANQSVQED
PRMMAFFDSLVRREIEGWSSDSDSDLSESTILQLHAGVSERSGYTDSESSASLPRSPPPTVDESADNAFHLGPLRVTTTNTVASTPPTPT
CEDAASRQQRLSALRRYQDKRLLALSNESDSEENVCEVELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAMRRRQK
TTREDKPSAPIKPTNTYIGEDNYDYPQIKVDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKIYKAYKWLRYSYISYSNNKDGET
SLVTGEADEGRAGTSHKDNPAPSSSKEACLNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVE
HPFETKKLNGKALSSRAEEPPSPPVPKASGSTLNSGSGNCPRTQSDDSEERSLETICANHNNGRLHPRPPHPHNNGQNLGELEVVAYSSP

--------------------------------------------------------------

>34243_34243_17_GPHN-DCAF5_GPHN_chr14_67147903_ENST00000478722_DCAF5_chr14_69558604_ENST00000389997_length(amino acids)=223AA_BP=1
MIVKLKHRQAGMDVIEHRGQASPQGQELGPVAVESYTHGTLEGQVSTIAQERKRRILYEIFEIYPTAVFCKIPEATITHCKDSDTDLMVV
VSKDHSLGRHVSQRSHRTDRSREKPEPGARGPGARSPRRARQLGSQRSARRAGKEGEATECTVACVGERPRRECAGPREGKESGRAAPSP

--------------------------------------------------------------

>34243_34243_18_GPHN-DCAF5_GPHN_chr14_67147903_ENST00000478722_DCAF5_chr14_69558604_ENST00000554215_length(amino acids)=800AA_BP=77
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSFSLLRYGGNLS
LQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVV
NGAFMVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWSPYKQPGCTGDLDGRIEDDSRCLYTHEEYISLVLNSGSGLSHDYANQSVQED
PRMMAFFDSLVRREIEGWSSDSDSDLSESTILQLHAGVSERSGYTDSESSASLPRSPPPTVDESADNAFHLGPLRVTTTNTVASTPPTPT
CEDAASRQQRLSALRRYQDKRLLALSNESDSEENVCEVELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAMRRRQK
TTREDKPSAPIKPTNTYIGEDNYDYPQIKVDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKIYKAYKWLRYSYISYSNNKDGET
SLVTGEADEGRAGTSHKDNPAPSSSKEACLNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVE
HPFETKKLNGKALSSRAEEPPSPPVPKASGSTLNSGSGNCPRTQSDDSEERSLETICANHNNGRLHPRPPHPHNNGQNLGELEVVAYSSP

--------------------------------------------------------------

>34243_34243_19_GPHN-DCAF5_GPHN_chr14_67147903_ENST00000478722_DCAF5_chr14_69558604_ENST00000556847_length(amino acids)=800AA_BP=77
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSFSLLRYGGNLS
LQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVV
NGAFMVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWSPYKQPGCTGDLDGRIEDDSRCLYTHEEYISLVLNSGSGLSHDYANQSVQED
PRMMAFFDSLVRREIEGWSSDSDSDLSESTILQLHAGVSERSGYTDSESSASLPRSPPPTVDESADNAFHLGPLRVTTTNTVASTPPTPT
CEDAASRQQRLSALRRYQDKRLLALSNESDSEENVCEVELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAMRRRQK
TTREDKPSAPIKPTNTYIGEDNYDYPQIKVDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKIYKAYKWLRYSYISYSNNKDGET
SLVTGEADEGRAGTSHKDNPAPSSSKEACLNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVE
HPFETKKLNGKALSSRAEEPPSPPVPKASGSTLNSGSGNCPRTQSDDSEERSLETICANHNNGRLHPRPPHPHNNGQNLGELEVVAYSSP

--------------------------------------------------------------

>34243_34243_20_GPHN-DCAF5_GPHN_chr14_67147903_ENST00000478722_DCAF5_chr14_69558604_ENST00000557386_length(amino acids)=800AA_BP=77
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSFSLLRYGGNLS
LQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVV
NGAFMVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWSPYKQPGCTGDLDGRIEDDSRCLYTHEEYISLVLNSGSGLSHDYANQSVQED
PRMMAFFDSLVRREIEGWSSDSDSDLSESTILQLHAGVSERSGYTDSESSASLPRSPPPTVDESADNAFHLGPLRVTTTNTVASTPPTPT
CEDAASRQQRLSALRRYQDKRLLALSNESDSEENVCEVELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAMRRRQK
TTREDKPSAPIKPTNTYIGEDNYDYPQIKVDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKIYKAYKWLRYSYISYSNNKDGET
SLVTGEADEGRAGTSHKDNPAPSSSKEACLNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVE
HPFETKKLNGKALSSRAEEPPSPPVPKASGSTLNSGSGNCPRTQSDDSEERSLETICANHNNGRLHPRPPHPHNNGQNLGELEVVAYSSP

--------------------------------------------------------------

>34243_34243_21_GPHN-DCAF5_GPHN_chr14_67147903_ENST00000543237_DCAF5_chr14_69558604_ENST00000341516_length(amino acids)=771AA_BP=48
MGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSFSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYD
IHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVVNGAFMVLKGHRSIVNQVRFNPHTYMICSS
GVEKIIKIWSPYKQPGCTGDLDGRIEDDSRCLYTHEEYISLVLNSGSGLSHDYANQSVQEDPRMMAFFDSLVRREIEGWSSDSDSDLSES
TILQLHAGVSERSGYTDSESSASLPRSPPPTVDESADNAFHLGPLRVTTTNTVASTPPTPTCEDAASRQQRLSALRRYQDKRLLALSNES
DSEENVCEVELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAMRRRQKTTREDKPSAPIKPTNTYIGEDNYDYPQIK
VDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKIYKAYKWLRYSYISYSNNKDGETSLVTGEADEGRAGTSHKDNPAPSSSKEAC
LNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVEHPFETKKLNGKALSSRAEEPPSPPVPKAS
GSTLNSGSGNCPRTQSDDSEERSLETICANHNNGRLHPRPPHPHNNGQNLGELEVVAYSSPGHSDTDRDNSSLTGTLLHKDCCGSEMACE

--------------------------------------------------------------

>34243_34243_22_GPHN-DCAF5_GPHN_chr14_67147903_ENST00000543237_DCAF5_chr14_69558604_ENST00000389997_length(amino acids)=155AA_BP=48
MGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSFSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYD

--------------------------------------------------------------

>34243_34243_23_GPHN-DCAF5_GPHN_chr14_67147903_ENST00000543237_DCAF5_chr14_69558604_ENST00000554215_length(amino acids)=771AA_BP=48
MGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSFSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYD
IHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVVNGAFMVLKGHRSIVNQVRFNPHTYMICSS
GVEKIIKIWSPYKQPGCTGDLDGRIEDDSRCLYTHEEYISLVLNSGSGLSHDYANQSVQEDPRMMAFFDSLVRREIEGWSSDSDSDLSES
TILQLHAGVSERSGYTDSESSASLPRSPPPTVDESADNAFHLGPLRVTTTNTVASTPPTPTCEDAASRQQRLSALRRYQDKRLLALSNES
DSEENVCEVELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAMRRRQKTTREDKPSAPIKPTNTYIGEDNYDYPQIK
VDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKIYKAYKWLRYSYISYSNNKDGETSLVTGEADEGRAGTSHKDNPAPSSSKEAC
LNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVEHPFETKKLNGKALSSRAEEPPSPPVPKAS
GSTLNSGSGNCPRTQSDDSEERSLETICANHNNGRLHPRPPHPHNNGQNLGELEVVAYSSPGHSDTDRDNSSLTGTLLHKDCCGSEMACE

--------------------------------------------------------------

>34243_34243_24_GPHN-DCAF5_GPHN_chr14_67147903_ENST00000543237_DCAF5_chr14_69558604_ENST00000556847_length(amino acids)=771AA_BP=48
MGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSFSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYD
IHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVVNGAFMVLKGHRSIVNQVRFNPHTYMICSS
GVEKIIKIWSPYKQPGCTGDLDGRIEDDSRCLYTHEEYISLVLNSGSGLSHDYANQSVQEDPRMMAFFDSLVRREIEGWSSDSDSDLSES
TILQLHAGVSERSGYTDSESSASLPRSPPPTVDESADNAFHLGPLRVTTTNTVASTPPTPTCEDAASRQQRLSALRRYQDKRLLALSNES
DSEENVCEVELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAMRRRQKTTREDKPSAPIKPTNTYIGEDNYDYPQIK
VDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKIYKAYKWLRYSYISYSNNKDGETSLVTGEADEGRAGTSHKDNPAPSSSKEAC
LNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVEHPFETKKLNGKALSSRAEEPPSPPVPKAS
GSTLNSGSGNCPRTQSDDSEERSLETICANHNNGRLHPRPPHPHNNGQNLGELEVVAYSSPGHSDTDRDNSSLTGTLLHKDCCGSEMACE

--------------------------------------------------------------

>34243_34243_25_GPHN-DCAF5_GPHN_chr14_67147903_ENST00000543237_DCAF5_chr14_69558604_ENST00000557386_length(amino acids)=771AA_BP=48
MGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSFSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYD
IHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVVNGAFMVLKGHRSIVNQVRFNPHTYMICSS
GVEKIIKIWSPYKQPGCTGDLDGRIEDDSRCLYTHEEYISLVLNSGSGLSHDYANQSVQEDPRMMAFFDSLVRREIEGWSSDSDSDLSES
TILQLHAGVSERSGYTDSESSASLPRSPPPTVDESADNAFHLGPLRVTTTNTVASTPPTPTCEDAASRQQRLSALRRYQDKRLLALSNES
DSEENVCEVELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAMRRRQKTTREDKPSAPIKPTNTYIGEDNYDYPQIK
VDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKIYKAYKWLRYSYISYSNNKDGETSLVTGEADEGRAGTSHKDNPAPSSSKEAC
LNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVEHPFETKKLNGKALSSRAEEPPSPPVPKAS
GSTLNSGSGNCPRTQSDDSEERSLETICANHNNGRLHPRPPHPHNNGQNLGELEVVAYSSPGHSDTDRDNSSLTGTLLHKDCCGSEMACE

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:67147903/chr14:69558604)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPHN

Q9NQX3

DCAF5

Q96JK2

FUNCTION: Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors (PubMed:25025157, PubMed:26613940). {ECO:0000250|UniProtKB:Q03555, ECO:0000269|PubMed:25025157, ECO:0000269|PubMed:26613940}.; FUNCTION: Has also a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. {ECO:0000269|PubMed:26613940}.FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDCAF5chr14:67147903chr14:69558604ENST0000034151649277_317221.66666666666666943.0RepeatNote=WD 5
TgeneDCAF5chr14:67147903chr14:69558604ENST0000034151649331_370221.66666666666666943.0RepeatNote=WD 6
TgeneDCAF5chr14:67147903chr14:69558604ENST0000055421549140_180139.66666666666666861.0RepeatNote=WD 3
TgeneDCAF5chr14:67147903chr14:69558604ENST0000055421549185_225139.66666666666666861.0RepeatNote=WD 4
TgeneDCAF5chr14:67147903chr14:69558604ENST0000055421549277_317139.66666666666666861.0RepeatNote=WD 5
TgeneDCAF5chr14:67147903chr14:69558604ENST0000055421549331_370139.66666666666666861.0RepeatNote=WD 6
TgeneDCAF5chr14:67147903chr14:69558604ENST0000055684749140_180139.66666666666666861.0RepeatNote=WD 3
TgeneDCAF5chr14:67147903chr14:69558604ENST0000055684749185_225139.66666666666666861.0RepeatNote=WD 4
TgeneDCAF5chr14:67147903chr14:69558604ENST0000055684749277_317139.66666666666666861.0RepeatNote=WD 5
TgeneDCAF5chr14:67147903chr14:69558604ENST0000055684749331_370139.66666666666666861.0RepeatNote=WD 6

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGPHNchr14:67147903chr14:69558604ENST00000315266+22214_16647.666666666666664737.0RegionNote=MPT Mo-transferase
HgeneGPHNchr14:67147903chr14:69558604ENST00000315266+222326_73647.666666666666664737.0RegionNote=MPT adenylyltransferase
HgeneGPHNchr14:67147903chr14:69558604ENST00000478722+22314_16647.666666666666664770.0RegionNote=MPT Mo-transferase
HgeneGPHNchr14:67147903chr14:69558604ENST00000478722+223326_73647.666666666666664770.0RegionNote=MPT adenylyltransferase
TgeneDCAF5chr14:67147903chr14:69558604ENST0000034151649140_180221.66666666666666943.0RepeatNote=WD 3
TgeneDCAF5chr14:67147903chr14:69558604ENST0000034151649185_225221.66666666666666943.0RepeatNote=WD 4
TgeneDCAF5chr14:67147903chr14:69558604ENST000003415164951_91221.66666666666666943.0RepeatNote=WD 1
TgeneDCAF5chr14:67147903chr14:69558604ENST000003415164999_139221.66666666666666943.0RepeatNote=WD 2
TgeneDCAF5chr14:67147903chr14:69558604ENST000005542154951_91139.66666666666666861.0RepeatNote=WD 1
TgeneDCAF5chr14:67147903chr14:69558604ENST000005542154999_139139.66666666666666861.0RepeatNote=WD 2
TgeneDCAF5chr14:67147903chr14:69558604ENST000005568474951_91139.66666666666666861.0RepeatNote=WD 1
TgeneDCAF5chr14:67147903chr14:69558604ENST000005568474999_139139.66666666666666861.0RepeatNote=WD 2


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1579_GPHN_67147903_DCAF5_69558604_ranked_0.pdbGPHN6714790367147903ENST00000389997DCAF5chr1469558604-
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSFSLLRYGGNLS
LQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVV
NGAFMVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWSPYKQPGCTGDLDGRIEDDSRCLYTHEEYISLVLNSGSGLSHDYANQSVQED
PRMMAFFDSLVRREIEGWSSDSDSDLSESTILQLHAGVSERSGYTDSESSASLPRSPPPTVDESADNAFHLGPLRVTTTNTVASTPPTPT
CEDAASRQQRLSALRRYQDKRLLALSNESDSEENVCEVELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAMRRRQK
TTREDKPSAPIKPTNTYIGEDNYDYPQIKVDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKIYKAYKWLRYSYISYSNNKDGET
SLVTGEADEGRAGTSHKDNPAPSSSKEACLNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVE
HPFETKKLNGKALSSRAEEPPSPPVPKASGSTLNSGSGNCPRTQSDDSEERSLETICANHNNGRLHPRPPHPHNNGQNLGELEVVAYSSP
800


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
GPHN_pLDDT.png
all structure
all structure
DCAF5_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
GPHNall structure
DCAF5


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneGPHNchr14:67147903chr14:69558604ENST00000315266+222140_31647.666666666666664737.0GABARAP
HgeneGPHNchr14:67147903chr14:69558604ENST00000478722+223140_31647.666666666666664770.0GABARAP


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Related Drugs to GPHN-DCAF5


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to GPHN-DCAF5


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGPHNC1854990Molybdenum Cofactor Deficiency, Complementation Group C5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneGPHNC0001956Alcohol Use Disorder1CTD_human
HgeneGPHNC0001973Alcoholic Intoxication, Chronic1CTD_human
HgeneGPHNC0009171Cocaine Abuse1CTD_human
HgeneGPHNC0085762Alcohol abuse1CTD_human
HgeneGPHNC0236736Cocaine-Related Disorders1CTD_human
HgeneGPHNC0543888Epileptic encephalopathy1GENOMICS_ENGLAND
HgeneGPHNC0600427Cocaine Dependence1CTD_human