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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:GPRC5B-C16orf96

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: GPRC5B-C16orf96
FusionPDB ID: 34497
FusionGDB2.0 ID: 34497
HgeneTgene
Gene symbol

GPRC5B

C16orf96

Gene ID

51704

342346

Gene nameG protein-coupled receptor class C group 5 member Bchromosome 16 open reading frame 96
SynonymsRAIG-2|RAIG2-
Cytomap

16p12.3

16p13.3

Type of geneprotein-codingprotein-coding
DescriptionG-protein coupled receptor family C group 5 member BG protein-coupled receptor, family C, group 1, member Bretinoic acid responsive gene proteinretinoic acid-induced gene 2 proteinuncharacterized protein C16orf96
Modification date2020032220200313
UniProtAcc

Q9NZH0

A6NNT2

Ensembl transtripts involved in fusion geneENST idsENST00000569479, ENST00000569847, 
ENST00000300571, ENST00000535671, 
ENST00000537135, ENST00000569102, 
ENST00000444310, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score3 X 4 X 3=364 X 8 X 6=192
# samples 410
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(10/192*10)=-0.941106310946431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: GPRC5B [Title/Abstract] AND C16orf96 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GPRC5B(19873159)-C16orf96(4621562), # samples:3
Anticipated loss of major functional domain due to fusion event.GPRC5B-C16orf96 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GPRC5B-C16orf96 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GPRC5B-C16orf96 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
GPRC5B-C16orf96 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across GPRC5B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across C16orf96 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-S3-AA0Z-01AGPRC5Bchr16

19873159

-C16orf96chr16

4621562

+
ChimerDB4BRCATCGA-S3-AA0ZGPRC5Bchr16

19873158

-C16orf96chr16

4621561

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000300571GPRC5Bchr1619873159-ENST00000444310C16orf96chr164621562+476213591243641450
ENST00000535671GPRC5Bchr1619873159-ENST00000444310C16orf96chr164621562+45701167041721390
ENST00000537135GPRC5Bchr1619873159-ENST00000444310C16orf96chr164621562+487914769344811462
ENST00000300571GPRC5Bchr1619873158-ENST00000444310C16orf96chr164621561+476213591243641450
ENST00000535671GPRC5Bchr1619873158-ENST00000444310C16orf96chr164621561+45701167041721390
ENST00000537135GPRC5Bchr1619873158-ENST00000444310C16orf96chr164621561+487914769344811462

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000300571ENST00000444310GPRC5Bchr1619873159-C16orf96chr164621562+0.003923890.99607605
ENST00000535671ENST00000444310GPRC5Bchr1619873159-C16orf96chr164621562+0.0030606690.9969393
ENST00000537135ENST00000444310GPRC5Bchr1619873159-C16orf96chr164621562+0.0028876550.9971123
ENST00000300571ENST00000444310GPRC5Bchr1619873158-C16orf96chr164621561+0.003923890.99607605
ENST00000535671ENST00000444310GPRC5Bchr1619873158-C16orf96chr164621561+0.0030606690.9969393
ENST00000537135ENST00000444310GPRC5Bchr1619873158-C16orf96chr164621561+0.0028876550.9971123

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>34497_34497_1_GPRC5B-C16orf96_GPRC5B_chr16_19873158_ENST00000300571_C16orf96_chr16_4621561_ENST00000444310_length(amino acids)=1450AA_BP=449
MQQRGPGQGAPRAAATLAGAAVKLDPQAGVRGAGAAAAPQRCDSGRRPAGASALRGRGGRMFVASERKMRAHQVLTFLLLFVITSVASEN
ASTSRGCGLDLLPQYVSLCDLDAIWGIVVEAVAGAGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDET
ICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRHGTGPAGWQLVGLALCLMLVQVIIAVEWLVLTVLRDTRPACAYEPMDFVMALIYDMVL
LVVTLGLALFTLCGKFKRWKLNGAFLLITAFLSVLIWVAWMTMYLFGNVKLQQGDAWNDPTLAITLAASGWVFVIFHAIPEIHCTLLPAL
QENTPNYFDTSQPRMRETAFEEDVQLPRAYMENKAFSMDEHNAALRTAGFPNGSLGKRPSGSLGKRPSAPFRSNVYQPTEMAVVLNGGTS
MQTLQDLLTDLHALQVTITALRKEVDMLKNMLDKVHPERMDIFAEDFKIQNWKMVALQREVASLQNKFKTIPKTEDMVLWSGLHDAMFTS
EIGSSPLDLWQSVEQLPEAALAQTTKYLEATRAIQVSEPVQNPQLLQTVWHYEVPELLPEGSSAQAVSLSRAQEPAQPPALTPESAPGCT
TEFAPGPAPGTEPVPGLELGLELEPVPALGPVPGPSVTPGSLPAPWPVLGPVPAPGAQPPPLGDWPALPRRWPLPQGWPRVGSWPLWDLG
VLRPTQPQPSRAPPPATEFGSLWPRPLQPYQSRQGEALQLAAVQVKGEENDVPSLRGLRERARKDGAPKDRTRKDGVPKDRGGKDVDPKD
RAHKDDVPKDRGGKDVDPKDRAHKDDVPKDRGGKDGDPKDRVGKDGAPKEAQPKAPQSALHRLKTTAAIAAAAAAAYAAATSSAAQAAKV
AAKFVKDAPATKMAAIATDTAAAGPLGVFADVLGAGPSRGATESQILGDDSEIYEILSPSYSAASIGPDPALSQAMVATKQAMSPEDKKR
AVKYSMSHIAQIPVKHDSLKEEFAQLSCNLNQRLSYLANMGGPSSLGTTVDILQKKIGSLQKSRLKEEELERIWGNQIEMMKDRYITLDK
AVENLQIRMDEFKTLQAQIKRLEMNKVNKSTMEEELREKADRSALAGKASRVDLETVALELNEMIQGILFKVTIHEDSWKKAMEELSKDV
NTKLVHSDLDPLKKEMEEVWKIVRKLLIEGLRLDPDSAAGFRRKLFKRVKCISCDRPVEMMTGPQLITIRKAHLLSRLRPASANSCEYLQ
RQQMREQQWLQLQDLGIQEDCQQDWGDGPQNATSLKCKSCNLLTLYPYGDPHVIDYDSAEVDILGVDGILYKGRVNSQRGAQPLAVAKEL
AAVKAPSPPSQSLYDRVHSSALFGAICPPLCPRSSACSAASGPHLTMPARPPSLPPLLLLPPLIPSLRDPQQAPGSTRLSRAPHIESRVG

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>34497_34497_2_GPRC5B-C16orf96_GPRC5B_chr16_19873158_ENST00000535671_C16orf96_chr16_4621561_ENST00000444310_length(amino acids)=1390AA_BP=389
MFVASERKMRAHQVLTFLLLFVITSVASENASTSRGCGLDLLPQYVSLCDLDAIWGIVVEAVAGAGALITLLLMLILLVRLPFIKEKEKK
SPVGLHFLFLLGTLGLFGLTFAFIIQEDETICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRHGTGPAGWQLVGLALCLMLVQVIIAVEW
LVLTVLRDTRPACAYEPMDFVMALIYDMVLLVVTLGLALFTLCGKFKRWKLNGAFLLITAFLSVLIWVAWMTMYLFGNVKLQQGDAWNDP
TLAITLAASGWVFVIFHAIPEIHCTLLPALQENTPNYFDTSQPRMRETAFEEDVQLPRAYMENKAFSMDEHNAALRTAGFPNGSLGKRPS
GSLGKRPSAPFRSNVYQPTEMAVVLNGGTSMQTLQDLLTDLHALQVTITALRKEVDMLKNMLDKVHPERMDIFAEDFKIQNWKMVALQRE
VASLQNKFKTIPKTEDMVLWSGLHDAMFTSEIGSSPLDLWQSVEQLPEAALAQTTKYLEATRAIQVSEPVQNPQLLQTVWHYEVPELLPE
GSSAQAVSLSRAQEPAQPPALTPESAPGCTTEFAPGPAPGTEPVPGLELGLELEPVPALGPVPGPSVTPGSLPAPWPVLGPVPAPGAQPP
PLGDWPALPRRWPLPQGWPRVGSWPLWDLGVLRPTQPQPSRAPPPATEFGSLWPRPLQPYQSRQGEALQLAAVQVKGEENDVPSLRGLRE
RARKDGAPKDRTRKDGVPKDRGGKDVDPKDRAHKDDVPKDRGGKDVDPKDRAHKDDVPKDRGGKDGDPKDRVGKDGAPKEAQPKAPQSAL
HRLKTTAAIAAAAAAAYAAATSSAAQAAKVAAKFVKDAPATKMAAIATDTAAAGPLGVFADVLGAGPSRGATESQILGDDSEIYEILSPS
YSAASIGPDPALSQAMVATKQAMSPEDKKRAVKYSMSHIAQIPVKHDSLKEEFAQLSCNLNQRLSYLANMGGPSSLGTTVDILQKKIGSL
QKSRLKEEELERIWGNQIEMMKDRYITLDKAVENLQIRMDEFKTLQAQIKRLEMNKVNKSTMEEELREKADRSALAGKASRVDLETVALE
LNEMIQGILFKVTIHEDSWKKAMEELSKDVNTKLVHSDLDPLKKEMEEVWKIVRKLLIEGLRLDPDSAAGFRRKLFKRVKCISCDRPVEM
MTGPQLITIRKAHLLSRLRPASANSCEYLQRQQMREQQWLQLQDLGIQEDCQQDWGDGPQNATSLKCKSCNLLTLYPYGDPHVIDYDSAE
VDILGVDGILYKGRVNSQRGAQPLAVAKELAAVKAPSPPSQSLYDRVHSSALFGAICPPLCPRSSACSAASGPHLTMPARPPSLPPLLLL

--------------------------------------------------------------

>34497_34497_3_GPRC5B-C16orf96_GPRC5B_chr16_19873158_ENST00000537135_C16orf96_chr16_4621561_ENST00000444310_length(amino acids)=1462AA_BP=461
MPGGGLAVCVRLGVYRGVGDFERHRAGSILSASWTWCWCVSGKLLLMNPPWSVAWGQEGFRAGTPGSRYLPRMFVASERKMRAHQVLTFL
LLFVITSVASENASTSRGCGLDLLPQYVSLCDLDAIWGIVVEAVAGAGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFG
LTFAFIIQEDETICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRHGTGPAGWQLVGLALCLMLVQVIIAVEWLVLTVLRDTRPACAYEPM
DFVMALIYDMVLLVVTLGLALFTLCGKFKRWKLNGAFLLITAFLSVLIWVAWMTMYLFGNVKLQQGDAWNDPTLAITLAASGWVFVIFHA
IPEIHCTLLPALQENTPNYFDTSQPRMRETAFEEDVQLPRAYMENKAFSMDEHNAALRTAGFPNGSLGKRPSGSLGKRPSAPFRSNVYQP
TEMAVVLNGGTSMQTLQDLLTDLHALQVTITALRKEVDMLKNMLDKVHPERMDIFAEDFKIQNWKMVALQREVASLQNKFKTIPKTEDMV
LWSGLHDAMFTSEIGSSPLDLWQSVEQLPEAALAQTTKYLEATRAIQVSEPVQNPQLLQTVWHYEVPELLPEGSSAQAVSLSRAQEPAQP
PALTPESAPGCTTEFAPGPAPGTEPVPGLELGLELEPVPALGPVPGPSVTPGSLPAPWPVLGPVPAPGAQPPPLGDWPALPRRWPLPQGW
PRVGSWPLWDLGVLRPTQPQPSRAPPPATEFGSLWPRPLQPYQSRQGEALQLAAVQVKGEENDVPSLRGLRERARKDGAPKDRTRKDGVP
KDRGGKDVDPKDRAHKDDVPKDRGGKDVDPKDRAHKDDVPKDRGGKDGDPKDRVGKDGAPKEAQPKAPQSALHRLKTTAAIAAAAAAAYA
AATSSAAQAAKVAAKFVKDAPATKMAAIATDTAAAGPLGVFADVLGAGPSRGATESQILGDDSEIYEILSPSYSAASIGPDPALSQAMVA
TKQAMSPEDKKRAVKYSMSHIAQIPVKHDSLKEEFAQLSCNLNQRLSYLANMGGPSSLGTTVDILQKKIGSLQKSRLKEEELERIWGNQI
EMMKDRYITLDKAVENLQIRMDEFKTLQAQIKRLEMNKVNKSTMEEELREKADRSALAGKASRVDLETVALELNEMIQGILFKVTIHEDS
WKKAMEELSKDVNTKLVHSDLDPLKKEMEEVWKIVRKLLIEGLRLDPDSAAGFRRKLFKRVKCISCDRPVEMMTGPQLITIRKAHLLSRL
RPASANSCEYLQRQQMREQQWLQLQDLGIQEDCQQDWGDGPQNATSLKCKSCNLLTLYPYGDPHVIDYDSAEVDILGVDGILYKGRVNSQ
RGAQPLAVAKELAAVKAPSPPSQSLYDRVHSSALFGAICPPLCPRSSACSAASGPHLTMPARPPSLPPLLLLPPLIPSLRDPQQAPGSTR

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>34497_34497_4_GPRC5B-C16orf96_GPRC5B_chr16_19873159_ENST00000300571_C16orf96_chr16_4621562_ENST00000444310_length(amino acids)=1450AA_BP=449
MQQRGPGQGAPRAAATLAGAAVKLDPQAGVRGAGAAAAPQRCDSGRRPAGASALRGRGGRMFVASERKMRAHQVLTFLLLFVITSVASEN
ASTSRGCGLDLLPQYVSLCDLDAIWGIVVEAVAGAGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDET
ICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRHGTGPAGWQLVGLALCLMLVQVIIAVEWLVLTVLRDTRPACAYEPMDFVMALIYDMVL
LVVTLGLALFTLCGKFKRWKLNGAFLLITAFLSVLIWVAWMTMYLFGNVKLQQGDAWNDPTLAITLAASGWVFVIFHAIPEIHCTLLPAL
QENTPNYFDTSQPRMRETAFEEDVQLPRAYMENKAFSMDEHNAALRTAGFPNGSLGKRPSGSLGKRPSAPFRSNVYQPTEMAVVLNGGTS
MQTLQDLLTDLHALQVTITALRKEVDMLKNMLDKVHPERMDIFAEDFKIQNWKMVALQREVASLQNKFKTIPKTEDMVLWSGLHDAMFTS
EIGSSPLDLWQSVEQLPEAALAQTTKYLEATRAIQVSEPVQNPQLLQTVWHYEVPELLPEGSSAQAVSLSRAQEPAQPPALTPESAPGCT
TEFAPGPAPGTEPVPGLELGLELEPVPALGPVPGPSVTPGSLPAPWPVLGPVPAPGAQPPPLGDWPALPRRWPLPQGWPRVGSWPLWDLG
VLRPTQPQPSRAPPPATEFGSLWPRPLQPYQSRQGEALQLAAVQVKGEENDVPSLRGLRERARKDGAPKDRTRKDGVPKDRGGKDVDPKD
RAHKDDVPKDRGGKDVDPKDRAHKDDVPKDRGGKDGDPKDRVGKDGAPKEAQPKAPQSALHRLKTTAAIAAAAAAAYAAATSSAAQAAKV
AAKFVKDAPATKMAAIATDTAAAGPLGVFADVLGAGPSRGATESQILGDDSEIYEILSPSYSAASIGPDPALSQAMVATKQAMSPEDKKR
AVKYSMSHIAQIPVKHDSLKEEFAQLSCNLNQRLSYLANMGGPSSLGTTVDILQKKIGSLQKSRLKEEELERIWGNQIEMMKDRYITLDK
AVENLQIRMDEFKTLQAQIKRLEMNKVNKSTMEEELREKADRSALAGKASRVDLETVALELNEMIQGILFKVTIHEDSWKKAMEELSKDV
NTKLVHSDLDPLKKEMEEVWKIVRKLLIEGLRLDPDSAAGFRRKLFKRVKCISCDRPVEMMTGPQLITIRKAHLLSRLRPASANSCEYLQ
RQQMREQQWLQLQDLGIQEDCQQDWGDGPQNATSLKCKSCNLLTLYPYGDPHVIDYDSAEVDILGVDGILYKGRVNSQRGAQPLAVAKEL
AAVKAPSPPSQSLYDRVHSSALFGAICPPLCPRSSACSAASGPHLTMPARPPSLPPLLLLPPLIPSLRDPQQAPGSTRLSRAPHIESRVG

--------------------------------------------------------------

>34497_34497_5_GPRC5B-C16orf96_GPRC5B_chr16_19873159_ENST00000535671_C16orf96_chr16_4621562_ENST00000444310_length(amino acids)=1390AA_BP=389
MFVASERKMRAHQVLTFLLLFVITSVASENASTSRGCGLDLLPQYVSLCDLDAIWGIVVEAVAGAGALITLLLMLILLVRLPFIKEKEKK
SPVGLHFLFLLGTLGLFGLTFAFIIQEDETICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRHGTGPAGWQLVGLALCLMLVQVIIAVEW
LVLTVLRDTRPACAYEPMDFVMALIYDMVLLVVTLGLALFTLCGKFKRWKLNGAFLLITAFLSVLIWVAWMTMYLFGNVKLQQGDAWNDP
TLAITLAASGWVFVIFHAIPEIHCTLLPALQENTPNYFDTSQPRMRETAFEEDVQLPRAYMENKAFSMDEHNAALRTAGFPNGSLGKRPS
GSLGKRPSAPFRSNVYQPTEMAVVLNGGTSMQTLQDLLTDLHALQVTITALRKEVDMLKNMLDKVHPERMDIFAEDFKIQNWKMVALQRE
VASLQNKFKTIPKTEDMVLWSGLHDAMFTSEIGSSPLDLWQSVEQLPEAALAQTTKYLEATRAIQVSEPVQNPQLLQTVWHYEVPELLPE
GSSAQAVSLSRAQEPAQPPALTPESAPGCTTEFAPGPAPGTEPVPGLELGLELEPVPALGPVPGPSVTPGSLPAPWPVLGPVPAPGAQPP
PLGDWPALPRRWPLPQGWPRVGSWPLWDLGVLRPTQPQPSRAPPPATEFGSLWPRPLQPYQSRQGEALQLAAVQVKGEENDVPSLRGLRE
RARKDGAPKDRTRKDGVPKDRGGKDVDPKDRAHKDDVPKDRGGKDVDPKDRAHKDDVPKDRGGKDGDPKDRVGKDGAPKEAQPKAPQSAL
HRLKTTAAIAAAAAAAYAAATSSAAQAAKVAAKFVKDAPATKMAAIATDTAAAGPLGVFADVLGAGPSRGATESQILGDDSEIYEILSPS
YSAASIGPDPALSQAMVATKQAMSPEDKKRAVKYSMSHIAQIPVKHDSLKEEFAQLSCNLNQRLSYLANMGGPSSLGTTVDILQKKIGSL
QKSRLKEEELERIWGNQIEMMKDRYITLDKAVENLQIRMDEFKTLQAQIKRLEMNKVNKSTMEEELREKADRSALAGKASRVDLETVALE
LNEMIQGILFKVTIHEDSWKKAMEELSKDVNTKLVHSDLDPLKKEMEEVWKIVRKLLIEGLRLDPDSAAGFRRKLFKRVKCISCDRPVEM
MTGPQLITIRKAHLLSRLRPASANSCEYLQRQQMREQQWLQLQDLGIQEDCQQDWGDGPQNATSLKCKSCNLLTLYPYGDPHVIDYDSAE
VDILGVDGILYKGRVNSQRGAQPLAVAKELAAVKAPSPPSQSLYDRVHSSALFGAICPPLCPRSSACSAASGPHLTMPARPPSLPPLLLL

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>34497_34497_6_GPRC5B-C16orf96_GPRC5B_chr16_19873159_ENST00000537135_C16orf96_chr16_4621562_ENST00000444310_length(amino acids)=1462AA_BP=461
MPGGGLAVCVRLGVYRGVGDFERHRAGSILSASWTWCWCVSGKLLLMNPPWSVAWGQEGFRAGTPGSRYLPRMFVASERKMRAHQVLTFL
LLFVITSVASENASTSRGCGLDLLPQYVSLCDLDAIWGIVVEAVAGAGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFG
LTFAFIIQEDETICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRHGTGPAGWQLVGLALCLMLVQVIIAVEWLVLTVLRDTRPACAYEPM
DFVMALIYDMVLLVVTLGLALFTLCGKFKRWKLNGAFLLITAFLSVLIWVAWMTMYLFGNVKLQQGDAWNDPTLAITLAASGWVFVIFHA
IPEIHCTLLPALQENTPNYFDTSQPRMRETAFEEDVQLPRAYMENKAFSMDEHNAALRTAGFPNGSLGKRPSGSLGKRPSAPFRSNVYQP
TEMAVVLNGGTSMQTLQDLLTDLHALQVTITALRKEVDMLKNMLDKVHPERMDIFAEDFKIQNWKMVALQREVASLQNKFKTIPKTEDMV
LWSGLHDAMFTSEIGSSPLDLWQSVEQLPEAALAQTTKYLEATRAIQVSEPVQNPQLLQTVWHYEVPELLPEGSSAQAVSLSRAQEPAQP
PALTPESAPGCTTEFAPGPAPGTEPVPGLELGLELEPVPALGPVPGPSVTPGSLPAPWPVLGPVPAPGAQPPPLGDWPALPRRWPLPQGW
PRVGSWPLWDLGVLRPTQPQPSRAPPPATEFGSLWPRPLQPYQSRQGEALQLAAVQVKGEENDVPSLRGLRERARKDGAPKDRTRKDGVP
KDRGGKDVDPKDRAHKDDVPKDRGGKDVDPKDRAHKDDVPKDRGGKDGDPKDRVGKDGAPKEAQPKAPQSALHRLKTTAAIAAAAAAAYA
AATSSAAQAAKVAAKFVKDAPATKMAAIATDTAAAGPLGVFADVLGAGPSRGATESQILGDDSEIYEILSPSYSAASIGPDPALSQAMVA
TKQAMSPEDKKRAVKYSMSHIAQIPVKHDSLKEEFAQLSCNLNQRLSYLANMGGPSSLGTTVDILQKKIGSLQKSRLKEEELERIWGNQI
EMMKDRYITLDKAVENLQIRMDEFKTLQAQIKRLEMNKVNKSTMEEELREKADRSALAGKASRVDLETVALELNEMIQGILFKVTIHEDS
WKKAMEELSKDVNTKLVHSDLDPLKKEMEEVWKIVRKLLIEGLRLDPDSAAGFRRKLFKRVKCISCDRPVEMMTGPQLITIRKAHLLSRL
RPASANSCEYLQRQQMREQQWLQLQDLGIQEDCQQDWGDGPQNATSLKCKSCNLLTLYPYGDPHVIDYDSAEVDILGVDGILYKGRVNSQ
RGAQPLAVAKELAAVKAPSPPSQSLYDRVHSSALFGAICPPLCPRSSACSAASGPHLTMPARPPSLPPLLLLPPLIPSLRDPQQAPGSTR

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:19873159/chr16:4621562)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPRC5B

Q9NZH0

C16orf96

A6NNT2

FUNCTION: Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000300571-34116_126389.0404.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000300571-34148_162389.0404.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000300571-34184_199389.0404.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000300571-34221_234389.0404.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000300571-34256_271389.0404.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000300571-3429_56389.0404.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000300571-3478_94389.0404.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000535671-23116_126389.0405.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000535671-23148_162389.0405.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000535671-23184_199389.0405.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000535671-23221_234389.0405.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000535671-23256_271389.0405.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000535671-2329_56389.0405.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000535671-2378_94389.0405.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000569479-34116_126389.0404.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000569479-34148_162389.0404.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000569479-34184_199389.0404.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000569479-34221_234389.0404.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000569479-34256_271389.0404.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000569479-3429_56389.0404.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000569479-3478_94389.0404.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000569847-34116_126389.0404.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000569847-34148_162389.0404.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000569847-34184_199389.0404.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000569847-34221_234389.0404.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000569847-34256_271389.0404.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000569847-3429_56389.0404.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000569847-3478_94389.0404.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000300571-34116_126389.0404.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000300571-34148_162389.0404.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000300571-34184_199389.0404.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000300571-34221_234389.0404.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000300571-34256_271389.0404.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000300571-3429_56389.0404.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000300571-3478_94389.0404.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000535671-23116_126389.0405.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000535671-23148_162389.0405.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000535671-23184_199389.0405.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000535671-23221_234389.0405.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000535671-23256_271389.0405.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000535671-2329_56389.0405.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000535671-2378_94389.0405.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000569479-34116_126389.0404.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000569479-34148_162389.0404.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000569479-34184_199389.0404.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000569479-34221_234389.0404.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000569479-34256_271389.0404.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000569479-3429_56389.0404.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000569479-3478_94389.0404.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000569847-34116_126389.0404.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000569847-34148_162389.0404.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000569847-34184_199389.0404.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000569847-34221_234389.0404.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000569847-34256_271389.0404.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000569847-3429_56389.0404.0Topological domainExtracellular
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000569847-3478_94389.0404.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000300571-34127_147389.0404.0TransmembraneHelical%3B Name%3D3
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000300571-34163_183389.0404.0TransmembraneHelical%3B Name%3D4
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000300571-34200_220389.0404.0TransmembraneHelical%3B Name%3D5
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000300571-34235_255389.0404.0TransmembraneHelical%3B Name%3D6
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000300571-34272_292389.0404.0TransmembraneHelical%3B Name%3D7
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000300571-3457_77389.0404.0TransmembraneHelical%3B Name%3D1
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000300571-3495_115389.0404.0TransmembraneHelical%3B Name%3D2
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000535671-23127_147389.0405.0TransmembraneHelical%3B Name%3D3
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000535671-23163_183389.0405.0TransmembraneHelical%3B Name%3D4
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000535671-23200_220389.0405.0TransmembraneHelical%3B Name%3D5
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000535671-23235_255389.0405.0TransmembraneHelical%3B Name%3D6
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000535671-23272_292389.0405.0TransmembraneHelical%3B Name%3D7
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000535671-2357_77389.0405.0TransmembraneHelical%3B Name%3D1
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000535671-2395_115389.0405.0TransmembraneHelical%3B Name%3D2
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000569479-34127_147389.0404.0TransmembraneHelical%3B Name%3D3
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000569479-34163_183389.0404.0TransmembraneHelical%3B Name%3D4
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000569479-34200_220389.0404.0TransmembraneHelical%3B Name%3D5
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000569479-34235_255389.0404.0TransmembraneHelical%3B Name%3D6
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000569479-34272_292389.0404.0TransmembraneHelical%3B Name%3D7
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000569479-3457_77389.0404.0TransmembraneHelical%3B Name%3D1
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000569479-3495_115389.0404.0TransmembraneHelical%3B Name%3D2
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000569847-34127_147389.0404.0TransmembraneHelical%3B Name%3D3
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000569847-34163_183389.0404.0TransmembraneHelical%3B Name%3D4
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000569847-34200_220389.0404.0TransmembraneHelical%3B Name%3D5
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000569847-34235_255389.0404.0TransmembraneHelical%3B Name%3D6
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000569847-34272_292389.0404.0TransmembraneHelical%3B Name%3D7
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000569847-3457_77389.0404.0TransmembraneHelical%3B Name%3D1
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000569847-3495_115389.0404.0TransmembraneHelical%3B Name%3D2
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000300571-34127_147389.0404.0TransmembraneHelical%3B Name%3D3
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000300571-34163_183389.0404.0TransmembraneHelical%3B Name%3D4
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000300571-34200_220389.0404.0TransmembraneHelical%3B Name%3D5
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000300571-34235_255389.0404.0TransmembraneHelical%3B Name%3D6
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000300571-34272_292389.0404.0TransmembraneHelical%3B Name%3D7
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000300571-3457_77389.0404.0TransmembraneHelical%3B Name%3D1
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000300571-3495_115389.0404.0TransmembraneHelical%3B Name%3D2
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000535671-23127_147389.0405.0TransmembraneHelical%3B Name%3D3
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000535671-23163_183389.0405.0TransmembraneHelical%3B Name%3D4
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000535671-23200_220389.0405.0TransmembraneHelical%3B Name%3D5
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000535671-23235_255389.0405.0TransmembraneHelical%3B Name%3D6
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000535671-23272_292389.0405.0TransmembraneHelical%3B Name%3D7
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000535671-2357_77389.0405.0TransmembraneHelical%3B Name%3D1
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000535671-2395_115389.0405.0TransmembraneHelical%3B Name%3D2
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000569479-34127_147389.0404.0TransmembraneHelical%3B Name%3D3
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000569479-34163_183389.0404.0TransmembraneHelical%3B Name%3D4
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000569479-34200_220389.0404.0TransmembraneHelical%3B Name%3D5
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000569479-34235_255389.0404.0TransmembraneHelical%3B Name%3D6
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000569479-34272_292389.0404.0TransmembraneHelical%3B Name%3D7
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000569479-3457_77389.0404.0TransmembraneHelical%3B Name%3D1
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000569479-3495_115389.0404.0TransmembraneHelical%3B Name%3D2
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000569847-34127_147389.0404.0TransmembraneHelical%3B Name%3D3
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000569847-34163_183389.0404.0TransmembraneHelical%3B Name%3D4
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000569847-34200_220389.0404.0TransmembraneHelical%3B Name%3D5
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000569847-34235_255389.0404.0TransmembraneHelical%3B Name%3D6
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000569847-34272_292389.0404.0TransmembraneHelical%3B Name%3D7
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000569847-3457_77389.0404.0TransmembraneHelical%3B Name%3D1
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000569847-3495_115389.0404.0TransmembraneHelical%3B Name%3D2
TgeneC16orf96chr16:19873158chr16:4621561ENST00000444310016145_176140.01142.0Coiled coilOntology_term=ECO:0000255
TgeneC16orf96chr16:19873158chr16:4621561ENST00000444310016757_810140.01142.0Coiled coilOntology_term=ECO:0000255
TgeneC16orf96chr16:19873159chr16:4621562ENST00000444310016145_176140.01142.0Coiled coilOntology_term=ECO:0000255
TgeneC16orf96chr16:19873159chr16:4621562ENST00000444310016757_810140.01142.0Coiled coilOntology_term=ECO:0000255
TgeneC16orf96chr16:19873158chr16:4621561ENST00000444310016306_440140.01142.0Compositional biasNote=Pro-rich
TgeneC16orf96chr16:19873158chr16:4621561ENST00000444310016568_614140.01142.0Compositional biasNote=Ala-rich
TgeneC16orf96chr16:19873159chr16:4621562ENST00000444310016306_440140.01142.0Compositional biasNote=Pro-rich
TgeneC16orf96chr16:19873159chr16:4621562ENST00000444310016568_614140.01142.0Compositional biasNote=Ala-rich

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000300571-34293_403389.0404.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000535671-23293_403389.0405.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000569479-34293_403389.0404.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873158chr16:4621561ENST00000569847-34293_403389.0404.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000300571-34293_403389.0404.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000535671-23293_403389.0405.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000569479-34293_403389.0404.0Topological domainCytoplasmic
HgeneGPRC5Bchr16:19873159chr16:4621562ENST00000569847-34293_403389.0404.0Topological domainCytoplasmic
TgeneC16orf96chr16:19873158chr16:4621561ENST0000044431001674_101140.01142.0Coiled coilOntology_term=ECO:0000255
TgeneC16orf96chr16:19873159chr16:4621562ENST0000044431001674_101140.01142.0Coiled coilOntology_term=ECO:0000255


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
GPRC5B
C16orf96


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to GPRC5B-C16orf96


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to GPRC5B-C16orf96


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource