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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:GRB10-SCMH1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: GRB10-SCMH1
FusionPDB ID: 34627
FusionGDB2.0 ID: 34627
HgeneTgene
Gene symbol

GRB10

SCMH1

Gene ID

2887

22955

Gene namegrowth factor receptor bound protein 10Scm polycomb group protein homolog 1
SynonymsGRB-IR|Grb-10|IRBP|MEG1|RSSScml3
Cytomap

7p12.1

1p34.2

Type of geneprotein-codingprotein-coding
Descriptiongrowth factor receptor-bound protein 10GRB10 adapter proteinGRB10 adaptor proteininsulin receptor-binding protein Grb-IRmaternally expressed gene 1polycomb protein SCMH1sex comb on midleg homolog 1
Modification date2020032720200313
UniProtAcc

Q13322

.
Ensembl transtripts involved in fusion geneENST idsENST00000335866, ENST00000357271, 
ENST00000398810, ENST00000398812, 
ENST00000401949, ENST00000402497, 
ENST00000402578, ENST00000403097, 
ENST00000406641, ENST00000407526, 
ENST00000439599, ENST00000483819, 
ENST00000472037, ENST00000326197, 
ENST00000337495, ENST00000361191, 
ENST00000361705, ENST00000372595, 
ENST00000372596, ENST00000372597, 
ENST00000397171, ENST00000397174, 
ENST00000402904, ENST00000456518, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 10 X 8=104012 X 9 X 6=648
# samples 1614
** MAII scorelog2(16/1040*10)=-2.70043971814109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/648*10)=-2.21056698593966
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: GRB10 [Title/Abstract] AND SCMH1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GRB10(50682467)-SCMH1(41494398), # samples:3
Anticipated loss of major functional domain due to fusion event.GRB10-SCMH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GRB10-SCMH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GRB10-SCMH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GRB10-SCMH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GRB10-SCMH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
GRB10-SCMH1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
GRB10-SCMH1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGRB10

GO:0030178

negative regulation of Wnt signaling pathway

17376403

HgeneGRB10

GO:0030949

positive regulation of vascular endothelial growth factor receptor signaling pathway

15060076


check buttonFusion gene breakpoints across GRB10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SCMH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A6YS-01AGRB10chr7

50682467

-SCMH1chr1

41494398

-
ChimerDB4SARCTCGA-SI-AA8C-01AGRB10chr7

50682467

-SCMH1chr1

41494398

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000335866GRB10chr750682467-ENST00000456518SCMH1chr141494398-271614535111494327
ENST00000335866GRB10chr750682467-ENST00000397174SCMH1chr141494398-271614535111494327
ENST00000335866GRB10chr750682467-ENST00000402904SCMH1chr141494398-271614535111494327
ENST00000335866GRB10chr750682467-ENST00000361191SCMH1chr141494398-271614535111494327
ENST00000335866GRB10chr750682467-ENST00000397171SCMH1chr141494398-271614535111494327
ENST00000335866GRB10chr750682467-ENST00000361705SCMH1chr141494398-271614535111494327
ENST00000335866GRB10chr750682467-ENST00000326197SCMH1chr141494398-271414535111494327
ENST00000335866GRB10chr750682467-ENST00000372595SCMH1chr141494398-271414535111494327
ENST00000335866GRB10chr750682467-ENST00000337495SCMH1chr141494398-271414535111494327
ENST00000335866GRB10chr750682467-ENST00000372596SCMH1chr141494398-271414535111494327
ENST00000335866GRB10chr750682467-ENST00000372597SCMH1chr141494398-271414535111494327
ENST00000403097GRB10chr750682467-ENST00000456518SCMH1chr141494398-312118587811899372
ENST00000403097GRB10chr750682467-ENST00000397174SCMH1chr141494398-312118587811899372
ENST00000403097GRB10chr750682467-ENST00000402904SCMH1chr141494398-312118587811899372
ENST00000403097GRB10chr750682467-ENST00000361191SCMH1chr141494398-312118587811899372
ENST00000403097GRB10chr750682467-ENST00000397171SCMH1chr141494398-312118587811899372
ENST00000403097GRB10chr750682467-ENST00000361705SCMH1chr141494398-312118587811899372
ENST00000403097GRB10chr750682467-ENST00000326197SCMH1chr141494398-311918587811899372
ENST00000403097GRB10chr750682467-ENST00000372595SCMH1chr141494398-311918587811899372
ENST00000403097GRB10chr750682467-ENST00000337495SCMH1chr141494398-311918587811899372
ENST00000403097GRB10chr750682467-ENST00000372596SCMH1chr141494398-311918587811899372
ENST00000403097GRB10chr750682467-ENST00000372597SCMH1chr141494398-311918587811899372
ENST00000407526GRB10chr750682467-ENST00000456518SCMH1chr141494398-248012172751258327
ENST00000407526GRB10chr750682467-ENST00000397174SCMH1chr141494398-248012172751258327
ENST00000407526GRB10chr750682467-ENST00000402904SCMH1chr141494398-248012172751258327
ENST00000407526GRB10chr750682467-ENST00000361191SCMH1chr141494398-248012172751258327
ENST00000407526GRB10chr750682467-ENST00000397171SCMH1chr141494398-248012172751258327
ENST00000407526GRB10chr750682467-ENST00000361705SCMH1chr141494398-248012172751258327
ENST00000407526GRB10chr750682467-ENST00000326197SCMH1chr141494398-247812172751258327
ENST00000407526GRB10chr750682467-ENST00000372595SCMH1chr141494398-247812172751258327
ENST00000407526GRB10chr750682467-ENST00000337495SCMH1chr141494398-247812172751258327
ENST00000407526GRB10chr750682467-ENST00000372596SCMH1chr141494398-247812172751258327
ENST00000407526GRB10chr750682467-ENST00000372597SCMH1chr141494398-247812172751258327
ENST00000401949GRB10chr750682467-ENST00000456518SCMH1chr141494398-282815654701606378
ENST00000401949GRB10chr750682467-ENST00000397174SCMH1chr141494398-282815654701606378
ENST00000401949GRB10chr750682467-ENST00000402904SCMH1chr141494398-282815654701606378
ENST00000401949GRB10chr750682467-ENST00000361191SCMH1chr141494398-282815654701606378
ENST00000401949GRB10chr750682467-ENST00000397171SCMH1chr141494398-282815654701606378
ENST00000401949GRB10chr750682467-ENST00000361705SCMH1chr141494398-282815654701606378
ENST00000401949GRB10chr750682467-ENST00000326197SCMH1chr141494398-282615654701606378
ENST00000401949GRB10chr750682467-ENST00000372595SCMH1chr141494398-282615654701606378
ENST00000401949GRB10chr750682467-ENST00000337495SCMH1chr141494398-282615654701606378
ENST00000401949GRB10chr750682467-ENST00000372596SCMH1chr141494398-282615654701606378
ENST00000401949GRB10chr750682467-ENST00000372597SCMH1chr141494398-282615654701606378

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000335866ENST00000456518GRB10chr750682467-SCMH1chr141494398-0.0597651340.94023484
ENST00000335866ENST00000397174GRB10chr750682467-SCMH1chr141494398-0.0597651340.94023484
ENST00000335866ENST00000402904GRB10chr750682467-SCMH1chr141494398-0.0597651340.94023484
ENST00000335866ENST00000361191GRB10chr750682467-SCMH1chr141494398-0.0597651340.94023484
ENST00000335866ENST00000397171GRB10chr750682467-SCMH1chr141494398-0.0597651340.94023484
ENST00000335866ENST00000361705GRB10chr750682467-SCMH1chr141494398-0.0597651340.94023484
ENST00000335866ENST00000326197GRB10chr750682467-SCMH1chr141494398-0.059679180.94032085
ENST00000335866ENST00000372595GRB10chr750682467-SCMH1chr141494398-0.059679180.94032085
ENST00000335866ENST00000337495GRB10chr750682467-SCMH1chr141494398-0.059679180.94032085
ENST00000335866ENST00000372596GRB10chr750682467-SCMH1chr141494398-0.059679180.94032085
ENST00000335866ENST00000372597GRB10chr750682467-SCMH1chr141494398-0.059679180.94032085
ENST00000403097ENST00000456518GRB10chr750682467-SCMH1chr141494398-0.0236337320.9763663
ENST00000403097ENST00000397174GRB10chr750682467-SCMH1chr141494398-0.0236337320.9763663
ENST00000403097ENST00000402904GRB10chr750682467-SCMH1chr141494398-0.0236337320.9763663
ENST00000403097ENST00000361191GRB10chr750682467-SCMH1chr141494398-0.0236337320.9763663
ENST00000403097ENST00000397171GRB10chr750682467-SCMH1chr141494398-0.0236337320.9763663
ENST00000403097ENST00000361705GRB10chr750682467-SCMH1chr141494398-0.0236337320.9763663
ENST00000403097ENST00000326197GRB10chr750682467-SCMH1chr141494398-0.0235038140.97649616
ENST00000403097ENST00000372595GRB10chr750682467-SCMH1chr141494398-0.0235038140.97649616
ENST00000403097ENST00000337495GRB10chr750682467-SCMH1chr141494398-0.0235038140.97649616
ENST00000403097ENST00000372596GRB10chr750682467-SCMH1chr141494398-0.0235038140.97649616
ENST00000403097ENST00000372597GRB10chr750682467-SCMH1chr141494398-0.0235038140.97649616
ENST00000407526ENST00000456518GRB10chr750682467-SCMH1chr141494398-0.064907130.93509287
ENST00000407526ENST00000397174GRB10chr750682467-SCMH1chr141494398-0.064907130.93509287
ENST00000407526ENST00000402904GRB10chr750682467-SCMH1chr141494398-0.064907130.93509287
ENST00000407526ENST00000361191GRB10chr750682467-SCMH1chr141494398-0.064907130.93509287
ENST00000407526ENST00000397171GRB10chr750682467-SCMH1chr141494398-0.064907130.93509287
ENST00000407526ENST00000361705GRB10chr750682467-SCMH1chr141494398-0.064907130.93509287
ENST00000407526ENST00000326197GRB10chr750682467-SCMH1chr141494398-0.0646467360.9353532
ENST00000407526ENST00000372595GRB10chr750682467-SCMH1chr141494398-0.0646467360.9353532
ENST00000407526ENST00000337495GRB10chr750682467-SCMH1chr141494398-0.0646467360.9353532
ENST00000407526ENST00000372596GRB10chr750682467-SCMH1chr141494398-0.0646467360.9353532
ENST00000407526ENST00000372597GRB10chr750682467-SCMH1chr141494398-0.0646467360.9353532
ENST00000401949ENST00000456518GRB10chr750682467-SCMH1chr141494398-0.0255491230.9744509
ENST00000401949ENST00000397174GRB10chr750682467-SCMH1chr141494398-0.0255491230.9744509
ENST00000401949ENST00000402904GRB10chr750682467-SCMH1chr141494398-0.0255491230.9744509
ENST00000401949ENST00000361191GRB10chr750682467-SCMH1chr141494398-0.0255491230.9744509
ENST00000401949ENST00000397171GRB10chr750682467-SCMH1chr141494398-0.0255491230.9744509
ENST00000401949ENST00000361705GRB10chr750682467-SCMH1chr141494398-0.0255491230.9744509
ENST00000401949ENST00000326197GRB10chr750682467-SCMH1chr141494398-0.0255168060.97448325
ENST00000401949ENST00000372595GRB10chr750682467-SCMH1chr141494398-0.0255168060.97448325
ENST00000401949ENST00000337495GRB10chr750682467-SCMH1chr141494398-0.0255168060.97448325
ENST00000401949ENST00000372596GRB10chr750682467-SCMH1chr141494398-0.0255168060.97448325
ENST00000401949ENST00000372597GRB10chr750682467-SCMH1chr141494398-0.0255168060.97448325

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>34627_34627_1_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000335866_SCMH1_chr1_41494398_ENST00000326197_length(amino acids)=327AA_BP=
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVV
QVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYC

--------------------------------------------------------------

>34627_34627_2_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000335866_SCMH1_chr1_41494398_ENST00000337495_length(amino acids)=327AA_BP=
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVV
QVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYC

--------------------------------------------------------------

>34627_34627_3_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000335866_SCMH1_chr1_41494398_ENST00000361191_length(amino acids)=327AA_BP=
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVV
QVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYC

--------------------------------------------------------------

>34627_34627_4_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000335866_SCMH1_chr1_41494398_ENST00000361705_length(amino acids)=327AA_BP=
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVV
QVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYC

--------------------------------------------------------------

>34627_34627_5_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000335866_SCMH1_chr1_41494398_ENST00000372595_length(amino acids)=327AA_BP=
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVV
QVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYC

--------------------------------------------------------------

>34627_34627_6_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000335866_SCMH1_chr1_41494398_ENST00000372596_length(amino acids)=327AA_BP=
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVV
QVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYC

--------------------------------------------------------------

>34627_34627_7_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000335866_SCMH1_chr1_41494398_ENST00000372597_length(amino acids)=327AA_BP=
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVV
QVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYC

--------------------------------------------------------------

>34627_34627_8_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000335866_SCMH1_chr1_41494398_ENST00000397171_length(amino acids)=327AA_BP=
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVV
QVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYC

--------------------------------------------------------------

>34627_34627_9_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000335866_SCMH1_chr1_41494398_ENST00000397174_length(amino acids)=327AA_BP=
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVV
QVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYC

--------------------------------------------------------------

>34627_34627_10_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000335866_SCMH1_chr1_41494398_ENST00000402904_length(amino acids)=327AA_BP=
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVV
QVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYC

--------------------------------------------------------------

>34627_34627_11_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000335866_SCMH1_chr1_41494398_ENST00000456518_length(amino acids)=327AA_BP=
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVV
QVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYC

--------------------------------------------------------------

>34627_34627_12_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000401949_SCMH1_chr1_41494398_ENST00000326197_length(amino acids)=378AA_BP=
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK
VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWC
QQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH

--------------------------------------------------------------

>34627_34627_13_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000401949_SCMH1_chr1_41494398_ENST00000337495_length(amino acids)=378AA_BP=
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK
VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWC
QQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH

--------------------------------------------------------------

>34627_34627_14_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000401949_SCMH1_chr1_41494398_ENST00000361191_length(amino acids)=378AA_BP=
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK
VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWC
QQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH

--------------------------------------------------------------

>34627_34627_15_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000401949_SCMH1_chr1_41494398_ENST00000361705_length(amino acids)=378AA_BP=
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK
VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWC
QQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH

--------------------------------------------------------------

>34627_34627_16_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000401949_SCMH1_chr1_41494398_ENST00000372595_length(amino acids)=378AA_BP=
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK
VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWC
QQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH

--------------------------------------------------------------

>34627_34627_17_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000401949_SCMH1_chr1_41494398_ENST00000372596_length(amino acids)=378AA_BP=
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK
VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWC
QQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH

--------------------------------------------------------------

>34627_34627_18_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000401949_SCMH1_chr1_41494398_ENST00000372597_length(amino acids)=378AA_BP=
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK
VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWC
QQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH

--------------------------------------------------------------

>34627_34627_19_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000401949_SCMH1_chr1_41494398_ENST00000397171_length(amino acids)=378AA_BP=
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK
VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWC
QQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH

--------------------------------------------------------------

>34627_34627_20_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000401949_SCMH1_chr1_41494398_ENST00000397174_length(amino acids)=378AA_BP=
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK
VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWC
QQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH

--------------------------------------------------------------

>34627_34627_21_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000401949_SCMH1_chr1_41494398_ENST00000402904_length(amino acids)=378AA_BP=
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK
VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWC
QQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH

--------------------------------------------------------------

>34627_34627_22_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000401949_SCMH1_chr1_41494398_ENST00000456518_length(amino acids)=378AA_BP=
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK
VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWC
QQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH

--------------------------------------------------------------

>34627_34627_23_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000403097_SCMH1_chr1_41494398_ENST00000326197_length(amino acids)=372AA_BP=
MQAAGPLFRSKDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPP
RSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILA
DMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGS
QTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDHGLCIKG

--------------------------------------------------------------

>34627_34627_24_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000403097_SCMH1_chr1_41494398_ENST00000337495_length(amino acids)=372AA_BP=
MQAAGPLFRSKDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPP
RSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILA
DMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGS
QTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDHGLCIKG

--------------------------------------------------------------

>34627_34627_25_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000403097_SCMH1_chr1_41494398_ENST00000361191_length(amino acids)=372AA_BP=
MQAAGPLFRSKDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPP
RSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILA
DMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGS
QTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDHGLCIKG

--------------------------------------------------------------

>34627_34627_26_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000403097_SCMH1_chr1_41494398_ENST00000361705_length(amino acids)=372AA_BP=
MQAAGPLFRSKDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPP
RSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILA
DMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGS
QTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDHGLCIKG

--------------------------------------------------------------

>34627_34627_27_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000403097_SCMH1_chr1_41494398_ENST00000372595_length(amino acids)=372AA_BP=
MQAAGPLFRSKDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPP
RSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILA
DMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGS
QTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDHGLCIKG

--------------------------------------------------------------

>34627_34627_28_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000403097_SCMH1_chr1_41494398_ENST00000372596_length(amino acids)=372AA_BP=
MQAAGPLFRSKDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPP
RSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILA
DMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGS
QTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDHGLCIKG

--------------------------------------------------------------

>34627_34627_29_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000403097_SCMH1_chr1_41494398_ENST00000372597_length(amino acids)=372AA_BP=
MQAAGPLFRSKDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPP
RSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILA
DMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGS
QTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDHGLCIKG

--------------------------------------------------------------

>34627_34627_30_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000403097_SCMH1_chr1_41494398_ENST00000397171_length(amino acids)=372AA_BP=
MQAAGPLFRSKDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPP
RSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILA
DMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGS
QTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDHGLCIKG

--------------------------------------------------------------

>34627_34627_31_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000403097_SCMH1_chr1_41494398_ENST00000397174_length(amino acids)=372AA_BP=
MQAAGPLFRSKDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPP
RSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILA
DMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGS
QTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDHGLCIKG

--------------------------------------------------------------

>34627_34627_32_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000403097_SCMH1_chr1_41494398_ENST00000402904_length(amino acids)=372AA_BP=
MQAAGPLFRSKDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPP
RSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILA
DMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGS
QTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDHGLCIKG

--------------------------------------------------------------

>34627_34627_33_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000403097_SCMH1_chr1_41494398_ENST00000456518_length(amino acids)=372AA_BP=
MQAAGPLFRSKDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPP
RSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILA
DMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGS
QTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDHGLCIKG

--------------------------------------------------------------

>34627_34627_34_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000407526_SCMH1_chr1_41494398_ENST00000326197_length(amino acids)=327AA_BP=
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVV
QVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYC

--------------------------------------------------------------

>34627_34627_35_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000407526_SCMH1_chr1_41494398_ENST00000337495_length(amino acids)=327AA_BP=
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVV
QVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYC

--------------------------------------------------------------

>34627_34627_36_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000407526_SCMH1_chr1_41494398_ENST00000361191_length(amino acids)=327AA_BP=
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVV
QVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYC

--------------------------------------------------------------

>34627_34627_37_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000407526_SCMH1_chr1_41494398_ENST00000361705_length(amino acids)=327AA_BP=
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVV
QVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYC

--------------------------------------------------------------

>34627_34627_38_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000407526_SCMH1_chr1_41494398_ENST00000372595_length(amino acids)=327AA_BP=
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVV
QVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYC

--------------------------------------------------------------

>34627_34627_39_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000407526_SCMH1_chr1_41494398_ENST00000372596_length(amino acids)=327AA_BP=
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVV
QVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYC

--------------------------------------------------------------

>34627_34627_40_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000407526_SCMH1_chr1_41494398_ENST00000372597_length(amino acids)=327AA_BP=
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVV
QVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYC

--------------------------------------------------------------

>34627_34627_41_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000407526_SCMH1_chr1_41494398_ENST00000397171_length(amino acids)=327AA_BP=
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVV
QVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYC

--------------------------------------------------------------

>34627_34627_42_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000407526_SCMH1_chr1_41494398_ENST00000397174_length(amino acids)=327AA_BP=
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVV
QVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYC

--------------------------------------------------------------

>34627_34627_43_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000407526_SCMH1_chr1_41494398_ENST00000402904_length(amino acids)=327AA_BP=
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVV
QVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYC

--------------------------------------------------------------

>34627_34627_44_GRB10-SCMH1_GRB10_chr7_50682467_ENST00000407526_SCMH1_chr1_41494398_ENST00000456518_length(amino acids)=327AA_BP=
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVV
QVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYC

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:50682467/chr1:41494398)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GRB10

Q13322

.
FUNCTION: Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. {ECO:0000269|PubMed:12493740, ECO:0000269|PubMed:15060076, ECO:0000269|PubMed:16434550, ECO:0000269|PubMed:17376403}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGRB10chr7:50682467chr1:41494398ENST00000335866-1017166_250307.0537.0DomainRas-associating
HgeneGRB10chr7:50682467chr1:41494398ENST00000357271-815166_250319.0549.0DomainRas-associating
HgeneGRB10chr7:50682467chr1:41494398ENST00000398810-916166_250307.0537.0DomainRas-associating
HgeneGRB10chr7:50682467chr1:41494398ENST00000398812-916166_250365.0595.0DomainRas-associating
HgeneGRB10chr7:50682467chr1:41494398ENST00000401949-1219166_250365.0595.0DomainRas-associating
HgeneGRB10chr7:50682467chr1:41494398ENST00000402497-916166_250307.0537.0DomainRas-associating
HgeneGRB10chr7:50682467chr1:41494398ENST00000402578-916166_250307.0537.0DomainRas-associating
HgeneGRB10chr7:50682467chr1:41494398ENST00000403097-1118166_250359.0589.0DomainRas-associating
HgeneGRB10chr7:50682467chr1:41494398ENST00000406641-1017166_250307.0537.0DomainRas-associating
HgeneGRB10chr7:50682467chr1:41494398ENST00000407526-916166_250307.0537.0DomainRas-associating
HgeneGRB10chr7:50682467chr1:41494398ENST00000439599-916166_250359.0589.0DomainRas-associating
TgeneSCMH1chr7:50682467chr1:41494398ENST000003261971215593_658571.3333333333334661.0DomainSAM
TgeneSCMH1chr7:50682467chr1:41494398ENST000003374951215593_658559.3333333333334649.0DomainSAM
TgeneSCMH1chr7:50682467chr1:41494398ENST00000361191912593_658488.3333333333333578.0DomainSAM
TgeneSCMH1chr7:50682467chr1:41494398ENST000003617051013593_658502.3333333333333592.0DomainSAM
TgeneSCMH1chr7:50682467chr1:41494398ENST000003725951215593_658510.3333333333333600.0DomainSAM
TgeneSCMH1chr7:50682467chr1:41494398ENST000003725961316593_658488.3333333333333578.0DomainSAM
TgeneSCMH1chr7:50682467chr1:41494398ENST000003725971215593_658502.3333333333333592.0DomainSAM
TgeneSCMH1chr7:50682467chr1:41494398ENST000003971711114593_658488.3333333333333578.0DomainSAM
TgeneSCMH1chr7:50682467chr1:41494398ENST000004029041316593_658571.3333333333334661.0DomainSAM
TgeneSCMH1chr7:50682467chr1:41494398ENST0000045651869593_658391.3333333333333481.0DomainSAM

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGRB10chr7:50682467chr1:41494398ENST00000335866-1017290_399307.0537.0DomainPH
HgeneGRB10chr7:50682467chr1:41494398ENST00000335866-1017493_574307.0537.0DomainSH2
HgeneGRB10chr7:50682467chr1:41494398ENST00000357271-815290_399319.0549.0DomainPH
HgeneGRB10chr7:50682467chr1:41494398ENST00000357271-815493_574319.0549.0DomainSH2
HgeneGRB10chr7:50682467chr1:41494398ENST00000398810-916290_399307.0537.0DomainPH
HgeneGRB10chr7:50682467chr1:41494398ENST00000398810-916493_574307.0537.0DomainSH2
HgeneGRB10chr7:50682467chr1:41494398ENST00000398812-916290_399365.0595.0DomainPH
HgeneGRB10chr7:50682467chr1:41494398ENST00000398812-916493_574365.0595.0DomainSH2
HgeneGRB10chr7:50682467chr1:41494398ENST00000401949-1219290_399365.0595.0DomainPH
HgeneGRB10chr7:50682467chr1:41494398ENST00000401949-1219493_574365.0595.0DomainSH2
HgeneGRB10chr7:50682467chr1:41494398ENST00000402497-916290_399307.0537.0DomainPH
HgeneGRB10chr7:50682467chr1:41494398ENST00000402497-916493_574307.0537.0DomainSH2
HgeneGRB10chr7:50682467chr1:41494398ENST00000402578-916290_399307.0537.0DomainPH
HgeneGRB10chr7:50682467chr1:41494398ENST00000402578-916493_574307.0537.0DomainSH2
HgeneGRB10chr7:50682467chr1:41494398ENST00000403097-1118290_399359.0589.0DomainPH
HgeneGRB10chr7:50682467chr1:41494398ENST00000403097-1118493_574359.0589.0DomainSH2
HgeneGRB10chr7:50682467chr1:41494398ENST00000406641-1017290_399307.0537.0DomainPH
HgeneGRB10chr7:50682467chr1:41494398ENST00000406641-1017493_574307.0537.0DomainSH2
HgeneGRB10chr7:50682467chr1:41494398ENST00000407526-916290_399307.0537.0DomainPH
HgeneGRB10chr7:50682467chr1:41494398ENST00000407526-916493_574307.0537.0DomainSH2
HgeneGRB10chr7:50682467chr1:41494398ENST00000439599-916290_399359.0589.0DomainPH
HgeneGRB10chr7:50682467chr1:41494398ENST00000439599-916493_574359.0589.0DomainSH2
TgeneSCMH1chr7:50682467chr1:41494398ENST000003261971215134_235571.3333333333334661.0RepeatNote=MBT 2
TgeneSCMH1chr7:50682467chr1:41494398ENST00000326197121528_126571.3333333333334661.0RepeatNote=MBT 1
TgeneSCMH1chr7:50682467chr1:41494398ENST000003374951215134_235559.3333333333334649.0RepeatNote=MBT 2
TgeneSCMH1chr7:50682467chr1:41494398ENST00000337495121528_126559.3333333333334649.0RepeatNote=MBT 1
TgeneSCMH1chr7:50682467chr1:41494398ENST00000361191912134_235488.3333333333333578.0RepeatNote=MBT 2
TgeneSCMH1chr7:50682467chr1:41494398ENST0000036119191228_126488.3333333333333578.0RepeatNote=MBT 1
TgeneSCMH1chr7:50682467chr1:41494398ENST000003617051013134_235502.3333333333333592.0RepeatNote=MBT 2
TgeneSCMH1chr7:50682467chr1:41494398ENST00000361705101328_126502.3333333333333592.0RepeatNote=MBT 1
TgeneSCMH1chr7:50682467chr1:41494398ENST000003725951215134_235510.3333333333333600.0RepeatNote=MBT 2
TgeneSCMH1chr7:50682467chr1:41494398ENST00000372595121528_126510.3333333333333600.0RepeatNote=MBT 1
TgeneSCMH1chr7:50682467chr1:41494398ENST000003725961316134_235488.3333333333333578.0RepeatNote=MBT 2
TgeneSCMH1chr7:50682467chr1:41494398ENST00000372596131628_126488.3333333333333578.0RepeatNote=MBT 1
TgeneSCMH1chr7:50682467chr1:41494398ENST000003725971215134_235502.3333333333333592.0RepeatNote=MBT 2
TgeneSCMH1chr7:50682467chr1:41494398ENST00000372597121528_126502.3333333333333592.0RepeatNote=MBT 1
TgeneSCMH1chr7:50682467chr1:41494398ENST000003971711114134_235488.3333333333333578.0RepeatNote=MBT 2
TgeneSCMH1chr7:50682467chr1:41494398ENST00000397171111428_126488.3333333333333578.0RepeatNote=MBT 1
TgeneSCMH1chr7:50682467chr1:41494398ENST000004029041316134_235571.3333333333334661.0RepeatNote=MBT 2
TgeneSCMH1chr7:50682467chr1:41494398ENST00000402904131628_126571.3333333333334661.0RepeatNote=MBT 1
TgeneSCMH1chr7:50682467chr1:41494398ENST0000045651869134_235391.3333333333333481.0RepeatNote=MBT 2
TgeneSCMH1chr7:50682467chr1:41494398ENST000004565186928_126391.3333333333333481.0RepeatNote=MBT 1


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>748_GRB10_50682467_SCMH1_41494398_ranked_0.pdbGRB105068246750682467ENST00000372597SCMH1chr141494398-
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK
VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWC
QQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH
378


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
GRB10_pLDDT.png
all structure
all structure
SCMH1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
GRB10
SCMH1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to GRB10-SCMH1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to GRB10-SCMH1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource