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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:GRB2-SS18L1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: GRB2-SS18L1
FusionPDB ID: 34651
FusionGDB2.0 ID: 34651
HgeneTgene
Gene symbol

GRB2

SS18L1

Gene ID

2885

26039

Gene namegrowth factor receptor bound protein 2SS18L1 subunit of BAF chromatin remodeling complex
SynonymsASH|EGFRBP-GRB2|Grb3-3|MST084|MSTP084|NCKAP2CREST|LP2261
Cytomap

17q25.1

20q13.33

Type of geneprotein-codingprotein-coding
Descriptiongrowth factor receptor-bound protein 2HT027SH2/SH3 adapter GRB2abundant SRC homologyepidermal growth factor receptor-binding protein GRB2epididymis secretory sperm binding proteingrowth factor receptor-bound protein 3protein Ashcalcium-responsive transactivatorSS18-like protein 1SS18L1, nBAF chromatin remodeling complex subunitSYT homolog 1synovial sarcoma translocation gene on chromosome 18-like 1
Modification date2020032720200313
UniProtAcc

GAB3

O75177

Ensembl transtripts involved in fusion geneENST idsENST00000316615, ENST00000316804, 
ENST00000392562, ENST00000392563, 
ENST00000392564, ENST00000578961, 
ENST00000462266, 		ENST00000491916, 
ENST00000331758, ENST00000370848, 
ENST00000421564, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score18 X 13 X 11=25741 X 2 X 1=2
# samples 251
** MAII scorelog2(25/2574*10)=-3.36401205355861
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/2*10)=2.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: GRB2 [Title/Abstract] AND SS18L1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GRB2(73389632)-SS18L1(60747738), # samples:2
Anticipated loss of major functional domain due to fusion event.GRB2-SS18L1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GRB2-SS18L1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GRB2-SS18L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GRB2-SS18L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GRB2-SS18L1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
GRB2-SS18L1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across GRB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SS18L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-38-4630-01AGRB2chr17

73389632

-SS18L1chr20

60737808

+
ChimerDB4LUADTCGA-38-4630-01AGRB2chr17

73389632

-SS18L1chr20

60747738

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000392562GRB2chr1773389632-ENST00000421564SS18L1chr2060747738+35938611244723173
ENST00000392562GRB2chr1773389632-ENST00000331758SS18L1chr2060747738+44128611244723173
ENST00000392562GRB2chr1773389632-ENST00000370848SS18L1chr2060747738+35938611244723173
ENST00000316804GRB2chr1773389632-ENST00000421564SS18L1chr2060747738+3112380763242173
ENST00000316804GRB2chr1773389632-ENST00000331758SS18L1chr2060747738+3931380763242173
ENST00000316804GRB2chr1773389632-ENST00000370848SS18L1chr2060747738+3112380763242173
ENST00000316615GRB2chr1773389632-ENST00000421564SS18L1chr2060747738+3168436819298173
ENST00000316615GRB2chr1773389632-ENST00000331758SS18L1chr2060747738+3987436819298173
ENST00000316615GRB2chr1773389632-ENST00000370848SS18L1chr2060747738+3168436819298173
ENST00000392562GRB2chr1773389632-ENST00000421564SS18L1chr2060737808+41338618781675265
ENST00000392562GRB2chr1773389632-ENST00000331758SS18L1chr2060737808+49528618781675265
ENST00000392562GRB2chr1773389632-ENST00000370848SS18L1chr2060737808+41338618781675265
ENST00000316804GRB2chr1773389632-ENST00000421564SS18L1chr2060737808+36523803971194265
ENST00000316804GRB2chr1773389632-ENST00000331758SS18L1chr2060737808+44713803971194265
ENST00000316804GRB2chr1773389632-ENST00000370848SS18L1chr2060737808+36523803971194265
ENST00000316615GRB2chr1773389632-ENST00000421564SS18L1chr2060737808+37084364531250265
ENST00000316615GRB2chr1773389632-ENST00000331758SS18L1chr2060737808+45274364531250265
ENST00000316615GRB2chr1773389632-ENST00000370848SS18L1chr2060737808+37084364531250265

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000392562ENST00000421564GRB2chr1773389632-SS18L1chr2060747738+0.89060710.10939291
ENST00000392562ENST00000331758GRB2chr1773389632-SS18L1chr2060747738+0.71200220.28799778
ENST00000392562ENST00000370848GRB2chr1773389632-SS18L1chr2060747738+0.89060710.10939291
ENST00000316804ENST00000421564GRB2chr1773389632-SS18L1chr2060747738+0.85669860.14330146
ENST00000316804ENST00000331758GRB2chr1773389632-SS18L1chr2060747738+0.694971440.3050286
ENST00000316804ENST00000370848GRB2chr1773389632-SS18L1chr2060747738+0.85669860.14330146
ENST00000316615ENST00000421564GRB2chr1773389632-SS18L1chr2060747738+0.855305430.1446946
ENST00000316615ENST00000331758GRB2chr1773389632-SS18L1chr2060747738+0.692143440.30785653
ENST00000316615ENST00000370848GRB2chr1773389632-SS18L1chr2060747738+0.855305430.1446946
ENST00000392562ENST00000421564GRB2chr1773389632-SS18L1chr2060737808+0.0003238250.9996762
ENST00000392562ENST00000331758GRB2chr1773389632-SS18L1chr2060737808+0.0002437670.9997563
ENST00000392562ENST00000370848GRB2chr1773389632-SS18L1chr2060737808+0.0003238250.9996762
ENST00000316804ENST00000421564GRB2chr1773389632-SS18L1chr2060737808+0.0003899110.9996101
ENST00000316804ENST00000331758GRB2chr1773389632-SS18L1chr2060737808+0.0002489530.99975103
ENST00000316804ENST00000370848GRB2chr1773389632-SS18L1chr2060737808+0.0003899110.9996101
ENST00000316615ENST00000421564GRB2chr1773389632-SS18L1chr2060737808+0.0003936010.99960643
ENST00000316615ENST00000331758GRB2chr1773389632-SS18L1chr2060737808+0.0002513990.99974865
ENST00000316615ENST00000370848GRB2chr1773389632-SS18L1chr2060737808+0.0003936010.99960643

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>34651_34651_1_GRB2-SS18L1_GRB2_chr17_73389632_ENST00000316615_SS18L1_chr20_60737808_ENST00000331758_length(amino acids)=265AA_BP=
MQQTAPNTLPTTSMSISGPGYSHAGPASQGVPMQGQGTIGNYVSRTNINMQSNPVSMMQQQAATSHYSSAQGGSQHYQGQSSIAMMGQGS
QGSSMMGQRPMAPYRPSQQGSSQQYLGQEEYYGEQYSHSQGAAEPMGQQYYPDGHGDYAYQQSSYTEQSYDRSFEESTQHYYEGGNSQYS

--------------------------------------------------------------

>34651_34651_2_GRB2-SS18L1_GRB2_chr17_73389632_ENST00000316615_SS18L1_chr20_60737808_ENST00000370848_length(amino acids)=265AA_BP=
MQQTAPNTLPTTSMSISGPGYSHAGPASQGVPMQGQGTIGNYVSRTNINMQSNPVSMMQQQAATSHYSSAQGGSQHYQGQSSIAMMGQGS
QGSSMMGQRPMAPYRPSQQGSSQQYLGQEEYYGEQYSHSQGAAEPMGQQYYPDGHGDYAYQQSSYTEQSYDRSFEESTQHYYEGGNSQYS

--------------------------------------------------------------

>34651_34651_3_GRB2-SS18L1_GRB2_chr17_73389632_ENST00000316615_SS18L1_chr20_60737808_ENST00000421564_length(amino acids)=265AA_BP=
MQQTAPNTLPTTSMSISGPGYSHAGPASQGVPMQGQGTIGNYVSRTNINMQSNPVSMMQQQAATSHYSSAQGGSQHYQGQSSIAMMGQGS
QGSSMMGQRPMAPYRPSQQGSSQQYLGQEEYYGEQYSHSQGAAEPMGQQYYPDGHGDYAYQQSSYTEQSYDRSFEESTQHYYEGGNSQYS

--------------------------------------------------------------

>34651_34651_4_GRB2-SS18L1_GRB2_chr17_73389632_ENST00000316615_SS18L1_chr20_60747738_ENST00000331758_length(amino acids)=173AA_BP=1
MGEQVTNMSQFTRAAASPSGPWMNTLPQGLQPECVSLTAGNFHTGPVHSRRAAAAGQTALSAVLGSFRTAGLGLAGSRGTVTGLPGQTRS

--------------------------------------------------------------

>34651_34651_5_GRB2-SS18L1_GRB2_chr17_73389632_ENST00000316615_SS18L1_chr20_60747738_ENST00000370848_length(amino acids)=173AA_BP=1
MGEQVTNMSQFTRAAASPSGPWMNTLPQGLQPECVSLTAGNFHTGPVHSRRAAAAGQTALSAVLGSFRTAGLGLAGSRGTVTGLPGQTRS

--------------------------------------------------------------

>34651_34651_6_GRB2-SS18L1_GRB2_chr17_73389632_ENST00000316615_SS18L1_chr20_60747738_ENST00000421564_length(amino acids)=173AA_BP=1
MGEQVTNMSQFTRAAASPSGPWMNTLPQGLQPECVSLTAGNFHTGPVHSRRAAAAGQTALSAVLGSFRTAGLGLAGSRGTVTGLPGQTRS

--------------------------------------------------------------

>34651_34651_7_GRB2-SS18L1_GRB2_chr17_73389632_ENST00000316804_SS18L1_chr20_60737808_ENST00000331758_length(amino acids)=265AA_BP=
MQQTAPNTLPTTSMSISGPGYSHAGPASQGVPMQGQGTIGNYVSRTNINMQSNPVSMMQQQAATSHYSSAQGGSQHYQGQSSIAMMGQGS
QGSSMMGQRPMAPYRPSQQGSSQQYLGQEEYYGEQYSHSQGAAEPMGQQYYPDGHGDYAYQQSSYTEQSYDRSFEESTQHYYEGGNSQYS

--------------------------------------------------------------

>34651_34651_8_GRB2-SS18L1_GRB2_chr17_73389632_ENST00000316804_SS18L1_chr20_60737808_ENST00000370848_length(amino acids)=265AA_BP=
MQQTAPNTLPTTSMSISGPGYSHAGPASQGVPMQGQGTIGNYVSRTNINMQSNPVSMMQQQAATSHYSSAQGGSQHYQGQSSIAMMGQGS
QGSSMMGQRPMAPYRPSQQGSSQQYLGQEEYYGEQYSHSQGAAEPMGQQYYPDGHGDYAYQQSSYTEQSYDRSFEESTQHYYEGGNSQYS

--------------------------------------------------------------

>34651_34651_9_GRB2-SS18L1_GRB2_chr17_73389632_ENST00000316804_SS18L1_chr20_60737808_ENST00000421564_length(amino acids)=265AA_BP=
MQQTAPNTLPTTSMSISGPGYSHAGPASQGVPMQGQGTIGNYVSRTNINMQSNPVSMMQQQAATSHYSSAQGGSQHYQGQSSIAMMGQGS
QGSSMMGQRPMAPYRPSQQGSSQQYLGQEEYYGEQYSHSQGAAEPMGQQYYPDGHGDYAYQQSSYTEQSYDRSFEESTQHYYEGGNSQYS

--------------------------------------------------------------

>34651_34651_10_GRB2-SS18L1_GRB2_chr17_73389632_ENST00000316804_SS18L1_chr20_60747738_ENST00000331758_length(amino acids)=173AA_BP=1
MGEQVTNMSQFTRAAASPSGPWMNTLPQGLQPECVSLTAGNFHTGPVHSRRAAAAGQTALSAVLGSFRTAGLGLAGSRGTVTGLPGQTRS

--------------------------------------------------------------

>34651_34651_11_GRB2-SS18L1_GRB2_chr17_73389632_ENST00000316804_SS18L1_chr20_60747738_ENST00000370848_length(amino acids)=173AA_BP=1
MGEQVTNMSQFTRAAASPSGPWMNTLPQGLQPECVSLTAGNFHTGPVHSRRAAAAGQTALSAVLGSFRTAGLGLAGSRGTVTGLPGQTRS

--------------------------------------------------------------

>34651_34651_12_GRB2-SS18L1_GRB2_chr17_73389632_ENST00000316804_SS18L1_chr20_60747738_ENST00000421564_length(amino acids)=173AA_BP=1
MGEQVTNMSQFTRAAASPSGPWMNTLPQGLQPECVSLTAGNFHTGPVHSRRAAAAGQTALSAVLGSFRTAGLGLAGSRGTVTGLPGQTRS

--------------------------------------------------------------

>34651_34651_13_GRB2-SS18L1_GRB2_chr17_73389632_ENST00000392562_SS18L1_chr20_60737808_ENST00000331758_length(amino acids)=265AA_BP=
MQQTAPNTLPTTSMSISGPGYSHAGPASQGVPMQGQGTIGNYVSRTNINMQSNPVSMMQQQAATSHYSSAQGGSQHYQGQSSIAMMGQGS
QGSSMMGQRPMAPYRPSQQGSSQQYLGQEEYYGEQYSHSQGAAEPMGQQYYPDGHGDYAYQQSSYTEQSYDRSFEESTQHYYEGGNSQYS

--------------------------------------------------------------

>34651_34651_14_GRB2-SS18L1_GRB2_chr17_73389632_ENST00000392562_SS18L1_chr20_60737808_ENST00000370848_length(amino acids)=265AA_BP=
MQQTAPNTLPTTSMSISGPGYSHAGPASQGVPMQGQGTIGNYVSRTNINMQSNPVSMMQQQAATSHYSSAQGGSQHYQGQSSIAMMGQGS
QGSSMMGQRPMAPYRPSQQGSSQQYLGQEEYYGEQYSHSQGAAEPMGQQYYPDGHGDYAYQQSSYTEQSYDRSFEESTQHYYEGGNSQYS

--------------------------------------------------------------

>34651_34651_15_GRB2-SS18L1_GRB2_chr17_73389632_ENST00000392562_SS18L1_chr20_60737808_ENST00000421564_length(amino acids)=265AA_BP=
MQQTAPNTLPTTSMSISGPGYSHAGPASQGVPMQGQGTIGNYVSRTNINMQSNPVSMMQQQAATSHYSSAQGGSQHYQGQSSIAMMGQGS
QGSSMMGQRPMAPYRPSQQGSSQQYLGQEEYYGEQYSHSQGAAEPMGQQYYPDGHGDYAYQQSSYTEQSYDRSFEESTQHYYEGGNSQYS

--------------------------------------------------------------

>34651_34651_16_GRB2-SS18L1_GRB2_chr17_73389632_ENST00000392562_SS18L1_chr20_60747738_ENST00000331758_length(amino acids)=173AA_BP=1
MGEQVTNMSQFTRAAASPSGPWMNTLPQGLQPECVSLTAGNFHTGPVHSRRAAAAGQTALSAVLGSFRTAGLGLAGSRGTVTGLPGQTRS

--------------------------------------------------------------

>34651_34651_17_GRB2-SS18L1_GRB2_chr17_73389632_ENST00000392562_SS18L1_chr20_60747738_ENST00000370848_length(amino acids)=173AA_BP=1
MGEQVTNMSQFTRAAASPSGPWMNTLPQGLQPECVSLTAGNFHTGPVHSRRAAAAGQTALSAVLGSFRTAGLGLAGSRGTVTGLPGQTRS

--------------------------------------------------------------

>34651_34651_18_GRB2-SS18L1_GRB2_chr17_73389632_ENST00000392562_SS18L1_chr20_60747738_ENST00000421564_length(amino acids)=173AA_BP=1
MGEQVTNMSQFTRAAASPSGPWMNTLPQGLQPECVSLTAGNFHTGPVHSRRAAAAGQTALSAVLGSFRTAGLGLAGSRGTVTGLPGQTRS

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:73389632/chr20:60747738)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GRB2

GAB3

SS18L1

O75177

586FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSS18L1chr17:73389632chr20:60737808ENST00000331758311190_396125.33333333333333397.0Compositional biasNote=Gln-rich
TgeneSS18L1chr17:73389632chr20:60737808ENST00000370848211190_396128.333333333333341118.0Compositional biasNote=Gln-rich
TgeneSS18L1chr17:73389632chr20:60737808ENST00000421564312190_396125.333333333333331125.3333333333333Compositional biasNote=Gln-rich
TgeneSS18L1chr17:73389632chr20:60737808ENST00000331758311353_356125.33333333333333397.0MotifSH2-binding
TgeneSS18L1chr17:73389632chr20:60737808ENST00000331758311371_379125.33333333333333397.0MotifSH3-binding
TgeneSS18L1chr17:73389632chr20:60737808ENST00000331758311391_394125.33333333333333397.0MotifSH2-binding
TgeneSS18L1chr17:73389632chr20:60737808ENST00000370848211353_356128.333333333333341118.0MotifSH2-binding
TgeneSS18L1chr17:73389632chr20:60737808ENST00000370848211371_379128.333333333333341118.0MotifSH3-binding
TgeneSS18L1chr17:73389632chr20:60737808ENST00000370848211391_394128.333333333333341118.0MotifSH2-binding
TgeneSS18L1chr17:73389632chr20:60737808ENST00000421564312353_356125.333333333333331125.3333333333333MotifSH2-binding
TgeneSS18L1chr17:73389632chr20:60737808ENST00000421564312371_379125.333333333333331125.3333333333333MotifSH3-binding
TgeneSS18L1chr17:73389632chr20:60737808ENST00000421564312391_394125.333333333333331125.3333333333333MotifSH2-binding
TgeneSS18L1chr17:73389632chr20:60747738ENST00000331758711353_356305.3333333333333397.0MotifSH2-binding
TgeneSS18L1chr17:73389632chr20:60747738ENST00000331758711371_379305.3333333333333397.0MotifSH3-binding
TgeneSS18L1chr17:73389632chr20:60747738ENST00000331758711391_394305.3333333333333397.0MotifSH2-binding
TgeneSS18L1chr17:73389632chr20:60747738ENST00000370848611353_356308.33333333333331118.0MotifSH2-binding
TgeneSS18L1chr17:73389632chr20:60747738ENST00000370848611371_379308.33333333333331118.0MotifSH3-binding
TgeneSS18L1chr17:73389632chr20:60747738ENST00000370848611391_394308.33333333333331118.0MotifSH2-binding
TgeneSS18L1chr17:73389632chr20:60747738ENST00000421564712353_356305.33333333333331125.3333333333333MotifSH2-binding
TgeneSS18L1chr17:73389632chr20:60747738ENST00000421564712371_379305.33333333333331125.3333333333333MotifSH3-binding
TgeneSS18L1chr17:73389632chr20:60747738ENST00000421564712391_394305.33333333333331125.3333333333333MotifSH2-binding
TgeneSS18L1chr17:73389632chr20:60737808ENST00000331758311149_232125.33333333333333397.0RegionMethionine-rich intra-molecular domain
TgeneSS18L1chr17:73389632chr20:60737808ENST00000331758311246_317125.33333333333333397.0RegionMFD domain
TgeneSS18L1chr17:73389632chr20:60737808ENST00000331758311334_396125.33333333333333397.0RegionNecessary for nuclear localization
TgeneSS18L1chr17:73389632chr20:60737808ENST00000370848211149_232128.333333333333341118.0RegionMethionine-rich intra-molecular domain
TgeneSS18L1chr17:73389632chr20:60737808ENST00000370848211246_317128.333333333333341118.0RegionMFD domain
TgeneSS18L1chr17:73389632chr20:60737808ENST00000370848211334_396128.333333333333341118.0RegionNecessary for nuclear localization
TgeneSS18L1chr17:73389632chr20:60737808ENST00000421564312149_232125.333333333333331125.3333333333333RegionMethionine-rich intra-molecular domain
TgeneSS18L1chr17:73389632chr20:60737808ENST00000421564312246_317125.333333333333331125.3333333333333RegionMFD domain
TgeneSS18L1chr17:73389632chr20:60737808ENST00000421564312334_396125.333333333333331125.3333333333333RegionNecessary for nuclear localization
TgeneSS18L1chr17:73389632chr20:60747738ENST00000331758711334_396305.3333333333333397.0RegionNecessary for nuclear localization
TgeneSS18L1chr17:73389632chr20:60747738ENST00000370848611334_396308.33333333333331118.0RegionNecessary for nuclear localization
TgeneSS18L1chr17:73389632chr20:60747738ENST00000421564712334_396305.33333333333331125.3333333333333RegionNecessary for nuclear localization

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGRB2chr17:73389632chr20:60737808ENST00000316615-25156_21526.0177.0DomainSH3 2
HgeneGRB2chr17:73389632chr20:60737808ENST00000316615-251_5826.0177.0DomainSH3 1
HgeneGRB2chr17:73389632chr20:60737808ENST00000316615-2560_15226.0177.0DomainSH2
HgeneGRB2chr17:73389632chr20:60737808ENST00000316804-26156_21526.0218.0DomainSH3 2
HgeneGRB2chr17:73389632chr20:60737808ENST00000316804-261_5826.0218.0DomainSH3 1
HgeneGRB2chr17:73389632chr20:60737808ENST00000316804-2660_15226.0218.0DomainSH2
HgeneGRB2chr17:73389632chr20:60737808ENST00000392562-26156_21526.0218.0DomainSH3 2
HgeneGRB2chr17:73389632chr20:60737808ENST00000392562-261_5826.0218.0DomainSH3 1
HgeneGRB2chr17:73389632chr20:60737808ENST00000392562-2660_15226.0218.0DomainSH2
HgeneGRB2chr17:73389632chr20:60737808ENST00000392563-14156_21526.0177.0DomainSH3 2
HgeneGRB2chr17:73389632chr20:60737808ENST00000392563-141_5826.0177.0DomainSH3 1
HgeneGRB2chr17:73389632chr20:60737808ENST00000392563-1460_15226.0177.0DomainSH2
HgeneGRB2chr17:73389632chr20:60737808ENST00000392564-15156_21526.0218.0DomainSH3 2
HgeneGRB2chr17:73389632chr20:60737808ENST00000392564-151_5826.0218.0DomainSH3 1
HgeneGRB2chr17:73389632chr20:60737808ENST00000392564-1560_15226.0218.0DomainSH2
HgeneGRB2chr17:73389632chr20:60747738ENST00000316615-25156_21526.0177.0DomainSH3 2
HgeneGRB2chr17:73389632chr20:60747738ENST00000316615-251_5826.0177.0DomainSH3 1
HgeneGRB2chr17:73389632chr20:60747738ENST00000316615-2560_15226.0177.0DomainSH2
HgeneGRB2chr17:73389632chr20:60747738ENST00000316804-26156_21526.0218.0DomainSH3 2
HgeneGRB2chr17:73389632chr20:60747738ENST00000316804-261_5826.0218.0DomainSH3 1
HgeneGRB2chr17:73389632chr20:60747738ENST00000316804-2660_15226.0218.0DomainSH2
HgeneGRB2chr17:73389632chr20:60747738ENST00000392562-26156_21526.0218.0DomainSH3 2
HgeneGRB2chr17:73389632chr20:60747738ENST00000392562-261_5826.0218.0DomainSH3 1
HgeneGRB2chr17:73389632chr20:60747738ENST00000392562-2660_15226.0218.0DomainSH2
HgeneGRB2chr17:73389632chr20:60747738ENST00000392563-14156_21526.0177.0DomainSH3 2
HgeneGRB2chr17:73389632chr20:60747738ENST00000392563-141_5826.0177.0DomainSH3 1
HgeneGRB2chr17:73389632chr20:60747738ENST00000392563-1460_15226.0177.0DomainSH2
HgeneGRB2chr17:73389632chr20:60747738ENST00000392564-15156_21526.0218.0DomainSH3 2
HgeneGRB2chr17:73389632chr20:60747738ENST00000392564-151_5826.0218.0DomainSH3 1
HgeneGRB2chr17:73389632chr20:60747738ENST00000392564-1560_15226.0218.0DomainSH2
TgeneSS18L1chr17:73389632chr20:60747738ENST00000331758711190_396305.3333333333333397.0Compositional biasNote=Gln-rich
TgeneSS18L1chr17:73389632chr20:60747738ENST00000370848611190_396308.33333333333331118.0Compositional biasNote=Gln-rich
TgeneSS18L1chr17:73389632chr20:60747738ENST00000421564712190_396305.33333333333331125.3333333333333Compositional biasNote=Gln-rich
TgeneSS18L1chr17:73389632chr20:60737808ENST0000033175831150_53125.33333333333333397.0MotifSH2-binding
TgeneSS18L1chr17:73389632chr20:60737808ENST0000037084821150_53128.333333333333341118.0MotifSH2-binding
TgeneSS18L1chr17:73389632chr20:60737808ENST0000042156431250_53125.333333333333331125.3333333333333MotifSH2-binding
TgeneSS18L1chr17:73389632chr20:60747738ENST0000033175871150_53305.3333333333333397.0MotifSH2-binding
TgeneSS18L1chr17:73389632chr20:60747738ENST0000037084861150_53308.33333333333331118.0MotifSH2-binding
TgeneSS18L1chr17:73389632chr20:60747738ENST0000042156471250_53305.33333333333331125.3333333333333MotifSH2-binding
TgeneSS18L1chr17:73389632chr20:60747738ENST00000331758711149_232305.3333333333333397.0RegionMethionine-rich intra-molecular domain
TgeneSS18L1chr17:73389632chr20:60747738ENST00000331758711246_317305.3333333333333397.0RegionMFD domain
TgeneSS18L1chr17:73389632chr20:60747738ENST00000370848611149_232308.33333333333331118.0RegionMethionine-rich intra-molecular domain
TgeneSS18L1chr17:73389632chr20:60747738ENST00000370848611246_317308.33333333333331118.0RegionMFD domain
TgeneSS18L1chr17:73389632chr20:60747738ENST00000421564712149_232305.33333333333331125.3333333333333RegionMethionine-rich intra-molecular domain
TgeneSS18L1chr17:73389632chr20:60747738ENST00000421564712246_317305.33333333333331125.3333333333333RegionMFD domain


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
SS18L1SF3B4, RFX6, CREBBP, EP300, USP30, SMARCA4, ATF3, ELF5, HDAC2, SMAD1, SMAD3, STAT3, TCF7, HDAC4, NR1H3, BRD1, AATF, RLIM, TAF9B, GATAD1, PCGF6, MED30, ANKRD22, WHSC1L1, SKA3, CUL3, DGCR6, CSTF2, LGALS3, CTAGE5, SNRPB, SNRPC, FAM168A, SS18L1, MAPK1IP1L, BMI1, DPF3, DPF2, SMARCE1, SMARCD1, SMARCC1, SMARCC2, HGS, ESR2, TP53BP1, ATN1, GLTSCR1L, ZMIZ2, PAX8, CEP55, C1orf94, NAF1, BAG4, SSBP3, ZMYND19, USP54, TNK1, BRD3, SMARCA2, HNRNPH1, NR3C1, BCL7C, SMARCD3, SS18, SMARCB1, ARID1A, ARID1B, SMARCD2, BCL7A, DPF1, BRD7, ARID2, ACTL6A, PBRM1, PHF10, GLTSCR1, ACTC1, BCL7B, BRD9, STK11IP, T, ERG, ETS1, FEV, FOS, HNF4A, LHX3, MYOD1, PAX6, PAX7, SP7,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
GRB2
SS18L1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to GRB2-SS18L1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to GRB2-SS18L1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSS18L1C1862939AMYOTROPHIC LATERAL SCLEROSIS 11GENOMICS_ENGLAND