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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:AKT3-RGS7

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: AKT3-RGS7
FusionPDB ID: 3505
FusionGDB2.0 ID: 3505
HgeneTgene
Gene symbol

AKT3

RGS7

Gene ID

10000

6000

Gene nameAKT serine/threonine kinase 3regulator of G protein signaling 7
SynonymsMPPH|MPPH2|PKB-GAMMA|PKBG|PRKBG|RAC-PK-gamma|RAC-gamma|STK-2-
Cytomap

1q43-q44

1q43|1q23.1

Type of geneprotein-codingprotein-coding
DescriptionRAC-gamma serine/threonine-protein kinasePKB gammaRAC-gamma serine/threonine protein kinasev-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)regulator of G-protein signaling 7regulator of G-protein signaling RGS7regulator of G-protein signalling 7
Modification date2020031320200313
UniProtAcc

Q9Y243

.
Ensembl transtripts involved in fusion geneENST idsENST00000366540, ENST00000263826, 
ENST00000336199, ENST00000366539, 
ENST00000492957, 		ENST00000331110, 
ENST00000348120, ENST00000366562, 
ENST00000366563, ENST00000366564, 
ENST00000366565, ENST00000401882, 
ENST00000407727, ENST00000446183, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score18 X 15 X 7=189013 X 11 X 8=1144
# samples 2114
** MAII scorelog2(21/1890*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/1144*10)=-3.03058831983342
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: AKT3 [Title/Abstract] AND RGS7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)AKT3(244006427)-RGS7(240990472), # samples:1
Anticipated loss of major functional domain due to fusion event.AKT3-RGS7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AKT3-RGS7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AKT3-RGS7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AKT3-RGS7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AKT3-RGS7 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
AKT3-RGS7 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
AKT3-RGS7 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
AKT3-RGS7 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
AKT3-RGS7 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAKT3

GO:0043536

positive regulation of blood vessel endothelial cell migration

28254819

HgeneAKT3

GO:1905564

positive regulation of vascular endothelial cell proliferation

28254819

TgeneRGS7

GO:0043547

positive regulation of GTPase activity

10521509


check buttonFusion gene breakpoints across AKT3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RGS7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-0216-01BAKT3chr1

244006427

-RGS7chr1

240990472

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000336199AKT3chr1244006427-ENST00000331110RGS7chr1240990472-968112160936258
ENST00000336199AKT3chr1244006427-ENST00000348120RGS7chr1240990472-1642112160936258
ENST00000336199AKT3chr1244006427-ENST00000366563RGS7chr1240990472-1642112160936258
ENST00000336199AKT3chr1244006427-ENST00000366564RGS7chr1240990472-1561112160912250
ENST00000336199AKT3chr1244006427-ENST00000366565RGS7chr1240990472-1615112160966268
ENST00000336199AKT3chr1244006427-ENST00000446183RGS7chr1240990472-1497112160936258
ENST00000336199AKT3chr1244006427-ENST00000366562RGS7chr1240990472-913112160912251
ENST00000336199AKT3chr1244006427-ENST00000401882RGS7chr1240990472-937112160936259
ENST00000336199AKT3chr1244006427-ENST00000407727RGS7chr1240990472-991112160990277
ENST00000366539AKT3chr1244006427-ENST00000331110RGS7chr1240990472-11032472951071258
ENST00000366539AKT3chr1244006427-ENST00000348120RGS7chr1240990472-17772472951071258
ENST00000366539AKT3chr1244006427-ENST00000366563RGS7chr1240990472-17772472951071258
ENST00000366539AKT3chr1244006427-ENST00000366564RGS7chr1240990472-16962472951047250
ENST00000366539AKT3chr1244006427-ENST00000366565RGS7chr1240990472-17502472951101268
ENST00000366539AKT3chr1244006427-ENST00000446183RGS7chr1240990472-16322472951071258
ENST00000366539AKT3chr1244006427-ENST00000366562RGS7chr1240990472-10482472951047251
ENST00000366539AKT3chr1244006427-ENST00000401882RGS7chr1240990472-10722472951071259
ENST00000366539AKT3chr1244006427-ENST00000407727RGS7chr1240990472-11262472951125277
ENST00000263826AKT3chr1244006427-ENST00000331110RGS7chr1240990472-983127175951258
ENST00000263826AKT3chr1244006427-ENST00000348120RGS7chr1240990472-1657127175951258
ENST00000263826AKT3chr1244006427-ENST00000366563RGS7chr1240990472-1657127175951258
ENST00000263826AKT3chr1244006427-ENST00000366564RGS7chr1240990472-1576127175927250
ENST00000263826AKT3chr1244006427-ENST00000366565RGS7chr1240990472-1630127175981268
ENST00000263826AKT3chr1244006427-ENST00000446183RGS7chr1240990472-1512127175951258
ENST00000263826AKT3chr1244006427-ENST00000366562RGS7chr1240990472-928127175927251
ENST00000263826AKT3chr1244006427-ENST00000401882RGS7chr1240990472-952127175951259
ENST00000263826AKT3chr1244006427-ENST00000407727RGS7chr1240990472-10061271751005277

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000336199ENST00000331110AKT3chr1244006427-RGS7chr1240990472-0.0074975840.99250245
ENST00000336199ENST00000348120AKT3chr1244006427-RGS7chr1240990472-0.0010335460.99896646
ENST00000336199ENST00000366563AKT3chr1244006427-RGS7chr1240990472-0.0010335460.99896646
ENST00000336199ENST00000366564AKT3chr1244006427-RGS7chr1240990472-0.001177070.99882287
ENST00000336199ENST00000366565AKT3chr1244006427-RGS7chr1240990472-0.0008158830.9991841
ENST00000336199ENST00000446183AKT3chr1244006427-RGS7chr1240990472-0.0016051060.9983949
ENST00000336199ENST00000366562AKT3chr1244006427-RGS7chr1240990472-0.0061194710.9938805
ENST00000336199ENST00000401882AKT3chr1244006427-RGS7chr1240990472-0.0064120640.993588
ENST00000336199ENST00000407727AKT3chr1244006427-RGS7chr1240990472-0.0031738710.9968262
ENST00000366539ENST00000331110AKT3chr1244006427-RGS7chr1240990472-0.0080532520.99194676
ENST00000366539ENST00000348120AKT3chr1244006427-RGS7chr1240990472-0.0012069170.998793
ENST00000366539ENST00000366563AKT3chr1244006427-RGS7chr1240990472-0.0012069170.998793
ENST00000366539ENST00000366564AKT3chr1244006427-RGS7chr1240990472-0.0012139060.99878615
ENST00000366539ENST00000366565AKT3chr1244006427-RGS7chr1240990472-0.0009947650.99900526
ENST00000366539ENST00000446183AKT3chr1244006427-RGS7chr1240990472-0.0021716860.9978283
ENST00000366539ENST00000366562AKT3chr1244006427-RGS7chr1240990472-0.0069667010.9930333
ENST00000366539ENST00000401882AKT3chr1244006427-RGS7chr1240990472-0.0082554790.9917446
ENST00000366539ENST00000407727AKT3chr1244006427-RGS7chr1240990472-0.005665810.9943342
ENST00000263826ENST00000331110AKT3chr1244006427-RGS7chr1240990472-0.0076156620.9923844
ENST00000263826ENST00000348120AKT3chr1244006427-RGS7chr1240990472-0.0011575150.99884254
ENST00000263826ENST00000366563AKT3chr1244006427-RGS7chr1240990472-0.0011575150.99884254
ENST00000263826ENST00000366564AKT3chr1244006427-RGS7chr1240990472-0.0013311570.9986689
ENST00000263826ENST00000366565AKT3chr1244006427-RGS7chr1240990472-0.000925570.99907446
ENST00000263826ENST00000446183AKT3chr1244006427-RGS7chr1240990472-0.0018869220.99811304
ENST00000263826ENST00000366562AKT3chr1244006427-RGS7chr1240990472-0.005972970.994027
ENST00000263826ENST00000401882AKT3chr1244006427-RGS7chr1240990472-0.0067227530.99327725
ENST00000263826ENST00000407727AKT3chr1244006427-RGS7chr1240990472-0.003851490.99614847

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>3505_3505_1_AKT3-RGS7_AKT3_chr1_244006427_ENST00000263826_RGS7_chr1_240990472_ENST00000331110_length(amino acids)=258AA_BP=
MRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSD
DTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINL

--------------------------------------------------------------

>3505_3505_2_AKT3-RGS7_AKT3_chr1_244006427_ENST00000263826_RGS7_chr1_240990472_ENST00000348120_length(amino acids)=258AA_BP=
MRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSD
DTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINL

--------------------------------------------------------------

>3505_3505_3_AKT3-RGS7_AKT3_chr1_244006427_ENST00000263826_RGS7_chr1_240990472_ENST00000366562_length(amino acids)=251AA_BP=
MRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSD
DTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINL

--------------------------------------------------------------

>3505_3505_4_AKT3-RGS7_AKT3_chr1_244006427_ENST00000263826_RGS7_chr1_240990472_ENST00000366563_length(amino acids)=258AA_BP=
MRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSD
DTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINL

--------------------------------------------------------------

>3505_3505_5_AKT3-RGS7_AKT3_chr1_244006427_ENST00000263826_RGS7_chr1_240990472_ENST00000366564_length(amino acids)=250AA_BP=
MRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSD
DTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINL

--------------------------------------------------------------

>3505_3505_6_AKT3-RGS7_AKT3_chr1_244006427_ENST00000263826_RGS7_chr1_240990472_ENST00000366565_length(amino acids)=268AA_BP=
MRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSD
DTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINL

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>3505_3505_7_AKT3-RGS7_AKT3_chr1_244006427_ENST00000263826_RGS7_chr1_240990472_ENST00000401882_length(amino acids)=259AA_BP=
MRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSD
DTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINL

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>3505_3505_8_AKT3-RGS7_AKT3_chr1_244006427_ENST00000263826_RGS7_chr1_240990472_ENST00000407727_length(amino acids)=277AA_BP=
MRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSD
DTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINL
DSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKSGNSMDRRTSFEKFAQNVGRNIPIFPCHKNCTPTLR

--------------------------------------------------------------

>3505_3505_9_AKT3-RGS7_AKT3_chr1_244006427_ENST00000263826_RGS7_chr1_240990472_ENST00000446183_length(amino acids)=258AA_BP=
MRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSD
DTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINL

--------------------------------------------------------------

>3505_3505_10_AKT3-RGS7_AKT3_chr1_244006427_ENST00000336199_RGS7_chr1_240990472_ENST00000331110_length(amino acids)=258AA_BP=
MRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSD
DTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINL

--------------------------------------------------------------

>3505_3505_11_AKT3-RGS7_AKT3_chr1_244006427_ENST00000336199_RGS7_chr1_240990472_ENST00000348120_length(amino acids)=258AA_BP=
MRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSD
DTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINL

--------------------------------------------------------------

>3505_3505_12_AKT3-RGS7_AKT3_chr1_244006427_ENST00000336199_RGS7_chr1_240990472_ENST00000366562_length(amino acids)=251AA_BP=
MRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSD
DTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINL

--------------------------------------------------------------

>3505_3505_13_AKT3-RGS7_AKT3_chr1_244006427_ENST00000336199_RGS7_chr1_240990472_ENST00000366563_length(amino acids)=258AA_BP=
MRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSD
DTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINL

--------------------------------------------------------------

>3505_3505_14_AKT3-RGS7_AKT3_chr1_244006427_ENST00000336199_RGS7_chr1_240990472_ENST00000366564_length(amino acids)=250AA_BP=
MRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSD
DTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINL

--------------------------------------------------------------

>3505_3505_15_AKT3-RGS7_AKT3_chr1_244006427_ENST00000336199_RGS7_chr1_240990472_ENST00000366565_length(amino acids)=268AA_BP=
MRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSD
DTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINL

--------------------------------------------------------------

>3505_3505_16_AKT3-RGS7_AKT3_chr1_244006427_ENST00000336199_RGS7_chr1_240990472_ENST00000401882_length(amino acids)=259AA_BP=
MRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSD
DTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINL

--------------------------------------------------------------

>3505_3505_17_AKT3-RGS7_AKT3_chr1_244006427_ENST00000336199_RGS7_chr1_240990472_ENST00000407727_length(amino acids)=277AA_BP=
MRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSD
DTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINL
DSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKSGNSMDRRTSFEKFAQNVGRNIPIFPCHKNCTPTLR

--------------------------------------------------------------

>3505_3505_18_AKT3-RGS7_AKT3_chr1_244006427_ENST00000336199_RGS7_chr1_240990472_ENST00000446183_length(amino acids)=258AA_BP=
MRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSD
DTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINL

--------------------------------------------------------------

>3505_3505_19_AKT3-RGS7_AKT3_chr1_244006427_ENST00000366539_RGS7_chr1_240990472_ENST00000331110_length(amino acids)=258AA_BP=
MRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSD
DTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINL

--------------------------------------------------------------

>3505_3505_20_AKT3-RGS7_AKT3_chr1_244006427_ENST00000366539_RGS7_chr1_240990472_ENST00000348120_length(amino acids)=258AA_BP=
MRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSD
DTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINL

--------------------------------------------------------------

>3505_3505_21_AKT3-RGS7_AKT3_chr1_244006427_ENST00000366539_RGS7_chr1_240990472_ENST00000366562_length(amino acids)=251AA_BP=
MRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSD
DTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINL

--------------------------------------------------------------

>3505_3505_22_AKT3-RGS7_AKT3_chr1_244006427_ENST00000366539_RGS7_chr1_240990472_ENST00000366563_length(amino acids)=258AA_BP=
MRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSD
DTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINL

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>3505_3505_23_AKT3-RGS7_AKT3_chr1_244006427_ENST00000366539_RGS7_chr1_240990472_ENST00000366564_length(amino acids)=250AA_BP=
MRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSD
DTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINL

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>3505_3505_24_AKT3-RGS7_AKT3_chr1_244006427_ENST00000366539_RGS7_chr1_240990472_ENST00000366565_length(amino acids)=268AA_BP=
MRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSD
DTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINL

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>3505_3505_25_AKT3-RGS7_AKT3_chr1_244006427_ENST00000366539_RGS7_chr1_240990472_ENST00000401882_length(amino acids)=259AA_BP=
MRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSD
DTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINL

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>3505_3505_26_AKT3-RGS7_AKT3_chr1_244006427_ENST00000366539_RGS7_chr1_240990472_ENST00000407727_length(amino acids)=277AA_BP=
MRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSD
DTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINL
DSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKSGNSMDRRTSFEKFAQNVGRNIPIFPCHKNCTPTLR

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>3505_3505_27_AKT3-RGS7_AKT3_chr1_244006427_ENST00000366539_RGS7_chr1_240990472_ENST00000446183_length(amino acids)=258AA_BP=
MRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSD
DTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINL

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:244006427/chr1:240990472)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AKT3

Q9Y243

.
FUNCTION: AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. {ECO:0000269|PubMed:18524868, ECO:0000269|PubMed:21191416}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRGS7chr1:244006427chr1:240990472ENST00000348120515255_316150.0626.6666666666666DomainNote=G protein gamma
TgeneRGS7chr1:244006427chr1:240990472ENST00000348120515333_448150.0626.6666666666666DomainRGS
TgeneRGS7chr1:244006427chr1:240990472ENST00000366562716255_316203.0470.0DomainNote=G protein gamma
TgeneRGS7chr1:244006427chr1:240990472ENST00000366562716333_448203.0470.0DomainRGS
TgeneRGS7chr1:244006427chr1:240990472ENST00000366563818255_316203.0689.6666666666666DomainNote=G protein gamma
TgeneRGS7chr1:244006427chr1:240990472ENST00000366563818333_448203.0689.6666666666666DomainRGS
TgeneRGS7chr1:244006427chr1:240990472ENST00000366564817255_316203.0470.0DomainNote=G protein gamma
TgeneRGS7chr1:244006427chr1:240990472ENST00000366564817333_448203.0470.0DomainRGS
TgeneRGS7chr1:244006427chr1:240990472ENST00000366565818255_316203.0488.0DomainNote=G protein gamma
TgeneRGS7chr1:244006427chr1:240990472ENST00000366565818333_448203.0488.0DomainRGS
TgeneRGS7chr1:244006427chr1:240990472ENST00000401882514255_316150.0425.0DomainNote=G protein gamma
TgeneRGS7chr1:244006427chr1:240990472ENST00000401882514333_448150.0425.0DomainRGS
TgeneRGS7chr1:244006427chr1:240990472ENST00000407727717255_316203.0496.0DomainNote=G protein gamma
TgeneRGS7chr1:244006427chr1:240990472ENST00000407727717333_448203.0496.0DomainRGS

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAKT3chr1:244006427chr1:240990472ENST00000263826-113148_40515.333333333333334480.0DomainProtein kinase
HgeneAKT3chr1:244006427chr1:240990472ENST00000263826-113406_47915.333333333333334480.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:244006427chr1:240990472ENST00000263826-1135_10715.333333333333334480.0DomainPH
HgeneAKT3chr1:244006427chr1:240990472ENST00000336199-114148_40515.333333333333334476.0DomainProtein kinase
HgeneAKT3chr1:244006427chr1:240990472ENST00000336199-114406_47915.333333333333334476.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:244006427chr1:240990472ENST00000336199-1145_10715.333333333333334476.0DomainPH
HgeneAKT3chr1:244006427chr1:240990472ENST00000366539-214148_40515.333333333333334480.0DomainProtein kinase
HgeneAKT3chr1:244006427chr1:240990472ENST00000366539-214406_47915.333333333333334480.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:244006427chr1:240990472ENST00000366539-2145_10715.333333333333334480.0DomainPH
HgeneAKT3chr1:244006427chr1:240990472ENST00000366540-214148_40515.333333333333334466.0DomainProtein kinase
HgeneAKT3chr1:244006427chr1:240990472ENST00000366540-214406_47915.333333333333334466.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:244006427chr1:240990472ENST00000366540-2145_10715.333333333333334466.0DomainPH
HgeneAKT3chr1:244006427chr1:240990472ENST00000263826-113154_16215.333333333333334480.0Nucleotide bindingATP
HgeneAKT3chr1:244006427chr1:240990472ENST00000336199-114154_16215.333333333333334476.0Nucleotide bindingATP
HgeneAKT3chr1:244006427chr1:240990472ENST00000366539-214154_16215.333333333333334480.0Nucleotide bindingATP
HgeneAKT3chr1:244006427chr1:240990472ENST00000366540-214154_16215.333333333333334466.0Nucleotide bindingATP
TgeneRGS7chr1:244006427chr1:240990472ENST0000034812051537_112150.0626.6666666666666DomainDEP
TgeneRGS7chr1:244006427chr1:240990472ENST0000036656271637_112203.0470.0DomainDEP
TgeneRGS7chr1:244006427chr1:240990472ENST0000036656381837_112203.0689.6666666666666DomainDEP
TgeneRGS7chr1:244006427chr1:240990472ENST0000036656481737_112203.0470.0DomainDEP
TgeneRGS7chr1:244006427chr1:240990472ENST0000036656581837_112203.0488.0DomainDEP
TgeneRGS7chr1:244006427chr1:240990472ENST0000040188251437_112150.0425.0DomainDEP
TgeneRGS7chr1:244006427chr1:240990472ENST0000040772771737_112203.0496.0DomainDEP


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
AKT3
RGS7


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to AKT3-RGS7


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to AKT3-RGS7


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource