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Fusion Protein:GUK1-KDM5C |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: GUK1-KDM5C | FusionPDB ID: 35363 | FusionGDB2.0 ID: 35363 | Hgene | Tgene | Gene symbol | GUK1 | KDM5C | Gene ID | 2987 | 8242 |
Gene name | guanylate kinase 1 | lysine demethylase 5C | |
Synonyms | GMK | DXS1272E|JARID1C|MRX13|MRXJ|MRXSCJ|MRXSJ|SMCX|XE169 | |
Cytomap | 1q42.13 | Xp11.22 | |
Type of gene | protein-coding | protein-coding | |
Description | guanylate kinaseATP:GMP phosphotransferaseGMP kinase | lysine-specific demethylase 5CJmjC domain-containing protein SMCXJumonji, AT rich interactive domain 1C (RBP2-like)Jumonji/ARID domain-containing protein 1CSmcx homolog, X chromosomeSmcy homolog, X-linkedhistone demethylase JARID1Clysine (K)-specif | |
Modification date | 20200320 | 20200313 | |
UniProtAcc | Q16774 | P41229 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000470040, ENST00000312726, ENST00000366716, ENST00000366718, ENST00000366721, ENST00000366722, ENST00000366723, ENST00000366726, ENST00000366730, ENST00000391865, ENST00000366728, | ENST00000375379, ENST00000375383, ENST00000375401, ENST00000404049, ENST00000452825, ENST00000465402, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 14 X 13 X 6=1092 | 4 X 5 X 1=20 |
# samples | 16 | 5 | |
** MAII score | log2(16/1092*10)=-2.77082904603249 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/20*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: GUK1 [Title/Abstract] AND KDM5C [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | GUK1(228336098)-KDM5C(53228198), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | GUK1-KDM5C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GUK1-KDM5C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GUK1-KDM5C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. GUK1-KDM5C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. GUK1-KDM5C seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. GUK1-KDM5C seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. GUK1-KDM5C seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. GUK1-KDM5C seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. GUK1-KDM5C seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. GUK1-KDM5C seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | GUK1 | GO:0006163 | purine nucleotide metabolic process | 8663313 |
Hgene | GUK1 | GO:0006805 | xenobiotic metabolic process | 6306664 |
Tgene | KDM5C | GO:0034720 | histone H3-K4 demethylation | 17320160 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS5.0 | N/A | BE939838 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000366730 | GUK1 | chr1 | 228336098 | + | ENST00000452825 | KDM5C | chrX | 53228198 | + | 4295 | 734 | 2505 | 3404 | 299 |
ENST00000366730 | GUK1 | chr1 | 228336098 | + | ENST00000375401 | KDM5C | chrX | 53228198 | + | 4029 | 734 | 2239 | 3138 | 299 |
ENST00000366730 | GUK1 | chr1 | 228336098 | + | ENST00000404049 | KDM5C | chrX | 53228198 | + | 3924 | 734 | 2134 | 3033 | 299 |
ENST00000366730 | GUK1 | chr1 | 228336098 | + | ENST00000375379 | KDM5C | chrX | 53228198 | + | 3243 | 734 | 1453 | 2352 | 299 |
ENST00000366730 | GUK1 | chr1 | 228336098 | + | ENST00000375383 | KDM5C | chrX | 53228198 | + | 3243 | 734 | 1453 | 2352 | 299 |
ENST00000391865 | GUK1 | chr1 | 228336098 | + | ENST00000452825 | KDM5C | chrX | 53228198 | + | 4233 | 672 | 2443 | 3342 | 299 |
ENST00000391865 | GUK1 | chr1 | 228336098 | + | ENST00000375401 | KDM5C | chrX | 53228198 | + | 3967 | 672 | 36 | 1037 | 333 |
ENST00000391865 | GUK1 | chr1 | 228336098 | + | ENST00000404049 | KDM5C | chrX | 53228198 | + | 3862 | 672 | 36 | 1037 | 333 |
ENST00000391865 | GUK1 | chr1 | 228336098 | + | ENST00000375379 | KDM5C | chrX | 53228198 | + | 3181 | 672 | 36 | 1037 | 333 |
ENST00000391865 | GUK1 | chr1 | 228336098 | + | ENST00000375383 | KDM5C | chrX | 53228198 | + | 3181 | 672 | 36 | 1037 | 333 |
ENST00000366726 | GUK1 | chr1 | 228336098 | + | ENST00000452825 | KDM5C | chrX | 53228198 | + | 4191 | 630 | 2401 | 3300 | 299 |
ENST00000366726 | GUK1 | chr1 | 228336098 | + | ENST00000375401 | KDM5C | chrX | 53228198 | + | 3925 | 630 | 42 | 995 | 317 |
ENST00000366726 | GUK1 | chr1 | 228336098 | + | ENST00000404049 | KDM5C | chrX | 53228198 | + | 3820 | 630 | 42 | 995 | 317 |
ENST00000366726 | GUK1 | chr1 | 228336098 | + | ENST00000375379 | KDM5C | chrX | 53228198 | + | 3139 | 630 | 42 | 995 | 317 |
ENST00000366726 | GUK1 | chr1 | 228336098 | + | ENST00000375383 | KDM5C | chrX | 53228198 | + | 3139 | 630 | 42 | 995 | 317 |
ENST00000312726 | GUK1 | chr1 | 228336098 | + | ENST00000452825 | KDM5C | chrX | 53228198 | + | 4336 | 775 | 2546 | 3445 | 299 |
ENST00000312726 | GUK1 | chr1 | 228336098 | + | ENST00000375401 | KDM5C | chrX | 53228198 | + | 4070 | 775 | 205 | 1140 | 311 |
ENST00000312726 | GUK1 | chr1 | 228336098 | + | ENST00000404049 | KDM5C | chrX | 53228198 | + | 3965 | 775 | 205 | 1140 | 311 |
ENST00000312726 | GUK1 | chr1 | 228336098 | + | ENST00000375379 | KDM5C | chrX | 53228198 | + | 3284 | 775 | 205 | 1140 | 311 |
ENST00000312726 | GUK1 | chr1 | 228336098 | + | ENST00000375383 | KDM5C | chrX | 53228198 | + | 3284 | 775 | 205 | 1140 | 311 |
ENST00000366721 | GUK1 | chr1 | 228336098 | + | ENST00000452825 | KDM5C | chrX | 53228198 | + | 4135 | 574 | 2345 | 3244 | 299 |
ENST00000366721 | GUK1 | chr1 | 228336098 | + | ENST00000375401 | KDM5C | chrX | 53228198 | + | 3869 | 574 | 10 | 939 | 309 |
ENST00000366721 | GUK1 | chr1 | 228336098 | + | ENST00000404049 | KDM5C | chrX | 53228198 | + | 3764 | 574 | 10 | 939 | 309 |
ENST00000366721 | GUK1 | chr1 | 228336098 | + | ENST00000375379 | KDM5C | chrX | 53228198 | + | 3083 | 574 | 10 | 939 | 309 |
ENST00000366721 | GUK1 | chr1 | 228336098 | + | ENST00000375383 | KDM5C | chrX | 53228198 | + | 3083 | 574 | 10 | 939 | 309 |
ENST00000366718 | GUK1 | chr1 | 228336098 | + | ENST00000452825 | KDM5C | chrX | 53228198 | + | 4522 | 961 | 2732 | 3631 | 299 |
ENST00000366718 | GUK1 | chr1 | 228336098 | + | ENST00000375401 | KDM5C | chrX | 53228198 | + | 4256 | 961 | 394 | 1326 | 310 |
ENST00000366718 | GUK1 | chr1 | 228336098 | + | ENST00000404049 | KDM5C | chrX | 53228198 | + | 4151 | 961 | 394 | 1326 | 310 |
ENST00000366718 | GUK1 | chr1 | 228336098 | + | ENST00000375379 | KDM5C | chrX | 53228198 | + | 3470 | 961 | 394 | 1326 | 310 |
ENST00000366718 | GUK1 | chr1 | 228336098 | + | ENST00000375383 | KDM5C | chrX | 53228198 | + | 3470 | 961 | 394 | 1326 | 310 |
ENST00000366716 | GUK1 | chr1 | 228336098 | + | ENST00000452825 | KDM5C | chrX | 53228198 | + | 4154 | 593 | 2364 | 3263 | 299 |
ENST00000366716 | GUK1 | chr1 | 228336098 | + | ENST00000375401 | KDM5C | chrX | 53228198 | + | 3888 | 593 | 2098 | 2997 | 299 |
ENST00000366716 | GUK1 | chr1 | 228336098 | + | ENST00000404049 | KDM5C | chrX | 53228198 | + | 3783 | 593 | 1993 | 2892 | 299 |
ENST00000366716 | GUK1 | chr1 | 228336098 | + | ENST00000375379 | KDM5C | chrX | 53228198 | + | 3102 | 593 | 1312 | 2211 | 299 |
ENST00000366716 | GUK1 | chr1 | 228336098 | + | ENST00000375383 | KDM5C | chrX | 53228198 | + | 3102 | 593 | 1312 | 2211 | 299 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000366730 | ENST00000452825 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.010315264 | 0.9896847 |
ENST00000366730 | ENST00000375401 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.004822485 | 0.9951775 |
ENST00000366730 | ENST00000404049 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.004916173 | 0.99508375 |
ENST00000366730 | ENST00000375379 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.005024978 | 0.9949751 |
ENST00000366730 | ENST00000375383 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.005024978 | 0.9949751 |
ENST00000391865 | ENST00000452825 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.009946913 | 0.9900531 |
ENST00000391865 | ENST00000375401 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.006389135 | 0.9936108 |
ENST00000391865 | ENST00000404049 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.006663138 | 0.9933369 |
ENST00000391865 | ENST00000375379 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.00764333 | 0.99235666 |
ENST00000391865 | ENST00000375383 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.00764333 | 0.99235666 |
ENST00000366726 | ENST00000452825 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.010312284 | 0.98968774 |
ENST00000366726 | ENST00000375401 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.004891787 | 0.9951082 |
ENST00000366726 | ENST00000404049 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.004981254 | 0.9950187 |
ENST00000366726 | ENST00000375379 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.00504327 | 0.9949568 |
ENST00000366726 | ENST00000375383 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.00504327 | 0.9949568 |
ENST00000312726 | ENST00000452825 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.010179623 | 0.98982036 |
ENST00000312726 | ENST00000375401 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.00478188 | 0.9952181 |
ENST00000312726 | ENST00000404049 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.004890346 | 0.9951096 |
ENST00000312726 | ENST00000375379 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.004971488 | 0.99502856 |
ENST00000312726 | ENST00000375383 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.004971488 | 0.99502856 |
ENST00000366721 | ENST00000452825 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.010201464 | 0.98979855 |
ENST00000366721 | ENST00000375401 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.005142908 | 0.9948571 |
ENST00000366721 | ENST00000404049 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.005320458 | 0.9946795 |
ENST00000366721 | ENST00000375379 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.005570397 | 0.9944296 |
ENST00000366721 | ENST00000375383 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.005570397 | 0.9944296 |
ENST00000366718 | ENST00000452825 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.010859973 | 0.98914003 |
ENST00000366718 | ENST00000375401 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.00525299 | 0.994747 |
ENST00000366718 | ENST00000404049 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.005391444 | 0.9946085 |
ENST00000366718 | ENST00000375379 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.005575786 | 0.9944243 |
ENST00000366718 | ENST00000375383 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.005575786 | 0.9944243 |
ENST00000366716 | ENST00000452825 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.009893901 | 0.99010617 |
ENST00000366716 | ENST00000375401 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.004901583 | 0.9950984 |
ENST00000366716 | ENST00000404049 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.005030838 | 0.9949692 |
ENST00000366716 | ENST00000375379 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.004743964 | 0.995256 |
ENST00000366716 | ENST00000375383 | GUK1 | chr1 | 228336098 | + | KDM5C | chrX | 53228198 | + | 0.004743964 | 0.995256 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >35363_35363_1_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000312726_KDM5C_chrX_53228198_ENST00000375379_length(amino acids)=311AA_BP= MWLWKSPISSGGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSG NLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQA YAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPST -------------------------------------------------------------- >35363_35363_2_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000312726_KDM5C_chrX_53228198_ENST00000375383_length(amino acids)=311AA_BP= MWLWKSPISSGGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSG NLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQA YAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPST -------------------------------------------------------------- >35363_35363_3_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000312726_KDM5C_chrX_53228198_ENST00000375401_length(amino acids)=311AA_BP= MWLWKSPISSGGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSG NLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQA YAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPST -------------------------------------------------------------- >35363_35363_4_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000312726_KDM5C_chrX_53228198_ENST00000404049_length(amino acids)=311AA_BP= MWLWKSPISSGGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSG NLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQA YAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPST -------------------------------------------------------------- >35363_35363_5_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000312726_KDM5C_chrX_53228198_ENST00000452825_length(amino acids)=299AA_BP=212 MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH -------------------------------------------------------------- >35363_35363_6_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366716_KDM5C_chrX_53228198_ENST00000375379_length(amino acids)=299AA_BP=212 MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH -------------------------------------------------------------- >35363_35363_7_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366716_KDM5C_chrX_53228198_ENST00000375383_length(amino acids)=299AA_BP=212 MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH -------------------------------------------------------------- >35363_35363_8_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366716_KDM5C_chrX_53228198_ENST00000375401_length(amino acids)=299AA_BP=212 MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH -------------------------------------------------------------- >35363_35363_9_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366716_KDM5C_chrX_53228198_ENST00000404049_length(amino acids)=299AA_BP=212 MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH -------------------------------------------------------------- >35363_35363_10_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366716_KDM5C_chrX_53228198_ENST00000452825_length(amino acids)=299AA_BP=212 MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH -------------------------------------------------------------- >35363_35363_11_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366718_KDM5C_chrX_53228198_ENST00000375379_length(amino acids)=310AA_BP= MTTEAAPQQTGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGN LYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQAY AELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQ -------------------------------------------------------------- >35363_35363_12_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366718_KDM5C_chrX_53228198_ENST00000375383_length(amino acids)=310AA_BP= MTTEAAPQQTGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGN LYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQAY AELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQ -------------------------------------------------------------- >35363_35363_13_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366718_KDM5C_chrX_53228198_ENST00000375401_length(amino acids)=310AA_BP= MTTEAAPQQTGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGN LYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQAY AELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQ -------------------------------------------------------------- >35363_35363_14_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366718_KDM5C_chrX_53228198_ENST00000404049_length(amino acids)=310AA_BP= MTTEAAPQQTGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGN LYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQAY AELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQ -------------------------------------------------------------- >35363_35363_15_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366718_KDM5C_chrX_53228198_ENST00000452825_length(amino acids)=299AA_BP=212 MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH -------------------------------------------------------------- >35363_35363_16_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366721_KDM5C_chrX_53228198_ENST00000375379_length(amino acids)=309AA_BP= MGRAPPDGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSRESRALVEGYHEEPEARRGERQREVMQRDIAAGDFIEHAEFSGNL YGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQAYA ELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQE -------------------------------------------------------------- >35363_35363_17_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366721_KDM5C_chrX_53228198_ENST00000375383_length(amino acids)=309AA_BP= MGRAPPDGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSRESRALVEGYHEEPEARRGERQREVMQRDIAAGDFIEHAEFSGNL YGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQAYA ELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQE -------------------------------------------------------------- >35363_35363_18_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366721_KDM5C_chrX_53228198_ENST00000375401_length(amino acids)=309AA_BP= MGRAPPDGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSRESRALVEGYHEEPEARRGERQREVMQRDIAAGDFIEHAEFSGNL YGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQAYA ELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQE -------------------------------------------------------------- >35363_35363_19_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366721_KDM5C_chrX_53228198_ENST00000404049_length(amino acids)=309AA_BP= MGRAPPDGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSRESRALVEGYHEEPEARRGERQREVMQRDIAAGDFIEHAEFSGNL YGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQAYA ELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQE -------------------------------------------------------------- >35363_35363_20_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366721_KDM5C_chrX_53228198_ENST00000452825_length(amino acids)=299AA_BP=212 MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH -------------------------------------------------------------- >35363_35363_21_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366726_KDM5C_chrX_53228198_ENST00000375379_length(amino acids)=317AA_BP= MRPPWAGPHRTPLFSPPGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIE HAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIIN DSLDQAYAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPT -------------------------------------------------------------- >35363_35363_22_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366726_KDM5C_chrX_53228198_ENST00000375383_length(amino acids)=317AA_BP= MRPPWAGPHRTPLFSPPGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIE HAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIIN DSLDQAYAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPT -------------------------------------------------------------- >35363_35363_23_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366726_KDM5C_chrX_53228198_ENST00000375401_length(amino acids)=317AA_BP= MRPPWAGPHRTPLFSPPGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIE HAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIIN DSLDQAYAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPT -------------------------------------------------------------- >35363_35363_24_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366726_KDM5C_chrX_53228198_ENST00000404049_length(amino acids)=317AA_BP= MRPPWAGPHRTPLFSPPGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIE HAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIIN DSLDQAYAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPT -------------------------------------------------------------- >35363_35363_25_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366726_KDM5C_chrX_53228198_ENST00000452825_length(amino acids)=299AA_BP=212 MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH -------------------------------------------------------------- >35363_35363_26_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366730_KDM5C_chrX_53228198_ENST00000375379_length(amino acids)=299AA_BP=212 MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH -------------------------------------------------------------- >35363_35363_27_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366730_KDM5C_chrX_53228198_ENST00000375383_length(amino acids)=299AA_BP=212 MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH -------------------------------------------------------------- >35363_35363_28_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366730_KDM5C_chrX_53228198_ENST00000375401_length(amino acids)=299AA_BP=212 MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH -------------------------------------------------------------- >35363_35363_29_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366730_KDM5C_chrX_53228198_ENST00000404049_length(amino acids)=299AA_BP=212 MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH -------------------------------------------------------------- >35363_35363_30_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366730_KDM5C_chrX_53228198_ENST00000452825_length(amino acids)=299AA_BP=212 MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH -------------------------------------------------------------- >35363_35363_31_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000391865_KDM5C_chrX_53228198_ENST00000375379_length(amino acids)=333AA_BP= MSRRFSGRKRWPRMLRRPLAGLAAAALGRAPPDGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFV TREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLV KRLAAAQADMESIIINDSLDQAYAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEE -------------------------------------------------------------- >35363_35363_32_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000391865_KDM5C_chrX_53228198_ENST00000375383_length(amino acids)=333AA_BP= MSRRFSGRKRWPRMLRRPLAGLAAAALGRAPPDGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFV TREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLV KRLAAAQADMESIIINDSLDQAYAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEE -------------------------------------------------------------- >35363_35363_33_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000391865_KDM5C_chrX_53228198_ENST00000375401_length(amino acids)=333AA_BP= MSRRFSGRKRWPRMLRRPLAGLAAAALGRAPPDGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFV TREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLV KRLAAAQADMESIIINDSLDQAYAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEE -------------------------------------------------------------- >35363_35363_34_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000391865_KDM5C_chrX_53228198_ENST00000404049_length(amino acids)=333AA_BP= MSRRFSGRKRWPRMLRRPLAGLAAAALGRAPPDGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFV TREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLV KRLAAAQADMESIIINDSLDQAYAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEE -------------------------------------------------------------- >35363_35363_35_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000391865_KDM5C_chrX_53228198_ENST00000452825_length(amino acids)=299AA_BP=212 MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:228336098/chrX:53228198) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
GUK1 | KDM5C |
FUNCTION: Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) (PubMed:31201273). Involved in the cGMP metabolism in photoreceptors (By similarity). It may also have a role in the survival and growth progression of some tumors (PubMed:31201273). In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine (PubMed:197968, PubMed:6248551, PubMed:6306664). {ECO:0000250|UniProtKB:P46195, ECO:0000269|PubMed:197968, ECO:0000269|PubMed:31201273, ECO:0000269|PubMed:6248551, ECO:0000269|PubMed:6306664}. | FUNCTION: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:28262558). Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:P41230, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17468742, ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:28262558}. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | KDM5C | chr1:228336098 | chrX:53228198 | ENST00000375379 | 0 | 26 | 14_55 | 0 | 1558.0 | Domain | JmjN | |
Tgene | KDM5C | chr1:228336098 | chrX:53228198 | ENST00000375379 | 0 | 26 | 468_634 | 0 | 1558.0 | Domain | JmjC | |
Tgene | KDM5C | chr1:228336098 | chrX:53228198 | ENST00000375379 | 0 | 26 | 79_169 | 0 | 1558.0 | Domain | ARID | |
Tgene | KDM5C | chr1:228336098 | chrX:53228198 | ENST00000375383 | 0 | 25 | 14_55 | 0 | 1517.0 | Domain | JmjN | |
Tgene | KDM5C | chr1:228336098 | chrX:53228198 | ENST00000375383 | 0 | 25 | 468_634 | 0 | 1517.0 | Domain | JmjC | |
Tgene | KDM5C | chr1:228336098 | chrX:53228198 | ENST00000375383 | 0 | 25 | 79_169 | 0 | 1517.0 | Domain | ARID | |
Tgene | KDM5C | chr1:228336098 | chrX:53228198 | ENST00000375401 | 0 | 26 | 14_55 | 0 | 1561.0 | Domain | JmjN | |
Tgene | KDM5C | chr1:228336098 | chrX:53228198 | ENST00000375401 | 0 | 26 | 468_634 | 0 | 1561.0 | Domain | JmjC | |
Tgene | KDM5C | chr1:228336098 | chrX:53228198 | ENST00000375401 | 0 | 26 | 79_169 | 0 | 1561.0 | Domain | ARID | |
Tgene | KDM5C | chr1:228336098 | chrX:53228198 | ENST00000404049 | 0 | 26 | 14_55 | 0 | 1560.0 | Domain | JmjN | |
Tgene | KDM5C | chr1:228336098 | chrX:53228198 | ENST00000404049 | 0 | 26 | 468_634 | 0 | 1560.0 | Domain | JmjC | |
Tgene | KDM5C | chr1:228336098 | chrX:53228198 | ENST00000404049 | 0 | 26 | 79_169 | 0 | 1560.0 | Domain | ARID | |
Tgene | KDM5C | chr1:228336098 | chrX:53228198 | ENST00000452825 | 0 | 24 | 14_55 | 0 | 1380.0 | Domain | JmjN | |
Tgene | KDM5C | chr1:228336098 | chrX:53228198 | ENST00000452825 | 0 | 24 | 468_634 | 0 | 1380.0 | Domain | JmjC | |
Tgene | KDM5C | chr1:228336098 | chrX:53228198 | ENST00000452825 | 0 | 24 | 79_169 | 0 | 1380.0 | Domain | ARID | |
Tgene | KDM5C | chr1:228336098 | chrX:53228198 | ENST00000375379 | 0 | 26 | 1187_1248 | 0 | 1558.0 | Zinc finger | PHD-type 2 | |
Tgene | KDM5C | chr1:228336098 | chrX:53228198 | ENST00000375379 | 0 | 26 | 326_372 | 0 | 1558.0 | Zinc finger | PHD-type 1 | |
Tgene | KDM5C | chr1:228336098 | chrX:53228198 | ENST00000375379 | 0 | 26 | 707_759 | 0 | 1558.0 | Zinc finger | C5HC2 | |
Tgene | KDM5C | chr1:228336098 | chrX:53228198 | ENST00000375383 | 0 | 25 | 1187_1248 | 0 | 1517.0 | Zinc finger | PHD-type 2 | |
Tgene | KDM5C | chr1:228336098 | chrX:53228198 | ENST00000375383 | 0 | 25 | 326_372 | 0 | 1517.0 | Zinc finger | PHD-type 1 | |
Tgene | KDM5C | chr1:228336098 | chrX:53228198 | ENST00000375383 | 0 | 25 | 707_759 | 0 | 1517.0 | Zinc finger | C5HC2 | |
Tgene | KDM5C | chr1:228336098 | chrX:53228198 | ENST00000375401 | 0 | 26 | 1187_1248 | 0 | 1561.0 | Zinc finger | PHD-type 2 | |
Tgene | KDM5C | chr1:228336098 | chrX:53228198 | ENST00000375401 | 0 | 26 | 326_372 | 0 | 1561.0 | Zinc finger | PHD-type 1 | |
Tgene | KDM5C | chr1:228336098 | chrX:53228198 | ENST00000375401 | 0 | 26 | 707_759 | 0 | 1561.0 | Zinc finger | C5HC2 | |
Tgene | KDM5C | chr1:228336098 | chrX:53228198 | ENST00000404049 | 0 | 26 | 1187_1248 | 0 | 1560.0 | Zinc finger | PHD-type 2 | |
Tgene | KDM5C | chr1:228336098 | chrX:53228198 | ENST00000404049 | 0 | 26 | 326_372 | 0 | 1560.0 | Zinc finger | PHD-type 1 | |
Tgene | KDM5C | chr1:228336098 | chrX:53228198 | ENST00000404049 | 0 | 26 | 707_759 | 0 | 1560.0 | Zinc finger | C5HC2 | |
Tgene | KDM5C | chr1:228336098 | chrX:53228198 | ENST00000452825 | 0 | 24 | 1187_1248 | 0 | 1380.0 | Zinc finger | PHD-type 2 | |
Tgene | KDM5C | chr1:228336098 | chrX:53228198 | ENST00000452825 | 0 | 24 | 326_372 | 0 | 1380.0 | Zinc finger | PHD-type 1 | |
Tgene | KDM5C | chr1:228336098 | chrX:53228198 | ENST00000452825 | 0 | 24 | 707_759 | 0 | 1380.0 | Zinc finger | C5HC2 |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | GUK1 | chr1:228336098 | chrX:53228198 | ENST00000312726 | + | 1 | 9 | 4_186 | 0 | 198.0 | Domain | Guanylate kinase-like |
Hgene | GUK1 | chr1:228336098 | chrX:53228198 | ENST00000366716 | + | 1 | 7 | 4_186 | 0 | 198.0 | Domain | Guanylate kinase-like |
Hgene | GUK1 | chr1:228336098 | chrX:53228198 | ENST00000366718 | + | 1 | 8 | 4_186 | 0 | 198.0 | Domain | Guanylate kinase-like |
Hgene | GUK1 | chr1:228336098 | chrX:53228198 | ENST00000366726 | + | 1 | 8 | 4_186 | 0 | 198.0 | Domain | Guanylate kinase-like |
Hgene | GUK1 | chr1:228336098 | chrX:53228198 | ENST00000366728 | + | 1 | 7 | 4_186 | 0 | 242.0 | Domain | Guanylate kinase-like |
Hgene | GUK1 | chr1:228336098 | chrX:53228198 | ENST00000366730 | + | 1 | 8 | 4_186 | 0 | 198.0 | Domain | Guanylate kinase-like |
Hgene | GUK1 | chr1:228336098 | chrX:53228198 | ENST00000391865 | + | 1 | 8 | 4_186 | 0 | 219.0 | Domain | Guanylate kinase-like |
Hgene | GUK1 | chr1:228336098 | chrX:53228198 | ENST00000312726 | + | 1 | 9 | 14_19 | 0 | 198.0 | Nucleotide binding | ATP |
Hgene | GUK1 | chr1:228336098 | chrX:53228198 | ENST00000312726 | + | 1 | 9 | 171_172 | 0 | 198.0 | Nucleotide binding | ATP |
Hgene | GUK1 | chr1:228336098 | chrX:53228198 | ENST00000312726 | + | 1 | 9 | 37_51 | 0 | 198.0 | Nucleotide binding | Substrate binding |
Hgene | GUK1 | chr1:228336098 | chrX:53228198 | ENST00000366716 | + | 1 | 7 | 14_19 | 0 | 198.0 | Nucleotide binding | ATP |
Hgene | GUK1 | chr1:228336098 | chrX:53228198 | ENST00000366716 | + | 1 | 7 | 171_172 | 0 | 198.0 | Nucleotide binding | ATP |
Hgene | GUK1 | chr1:228336098 | chrX:53228198 | ENST00000366716 | + | 1 | 7 | 37_51 | 0 | 198.0 | Nucleotide binding | Substrate binding |
Hgene | GUK1 | chr1:228336098 | chrX:53228198 | ENST00000366718 | + | 1 | 8 | 14_19 | 0 | 198.0 | Nucleotide binding | ATP |
Hgene | GUK1 | chr1:228336098 | chrX:53228198 | ENST00000366718 | + | 1 | 8 | 171_172 | 0 | 198.0 | Nucleotide binding | ATP |
Hgene | GUK1 | chr1:228336098 | chrX:53228198 | ENST00000366718 | + | 1 | 8 | 37_51 | 0 | 198.0 | Nucleotide binding | Substrate binding |
Hgene | GUK1 | chr1:228336098 | chrX:53228198 | ENST00000366726 | + | 1 | 8 | 14_19 | 0 | 198.0 | Nucleotide binding | ATP |
Hgene | GUK1 | chr1:228336098 | chrX:53228198 | ENST00000366726 | + | 1 | 8 | 171_172 | 0 | 198.0 | Nucleotide binding | ATP |
Hgene | GUK1 | chr1:228336098 | chrX:53228198 | ENST00000366726 | + | 1 | 8 | 37_51 | 0 | 198.0 | Nucleotide binding | Substrate binding |
Hgene | GUK1 | chr1:228336098 | chrX:53228198 | ENST00000366728 | + | 1 | 7 | 14_19 | 0 | 242.0 | Nucleotide binding | ATP |
Hgene | GUK1 | chr1:228336098 | chrX:53228198 | ENST00000366728 | + | 1 | 7 | 171_172 | 0 | 242.0 | Nucleotide binding | ATP |
Hgene | GUK1 | chr1:228336098 | chrX:53228198 | ENST00000366728 | + | 1 | 7 | 37_51 | 0 | 242.0 | Nucleotide binding | Substrate binding |
Hgene | GUK1 | chr1:228336098 | chrX:53228198 | ENST00000366730 | + | 1 | 8 | 14_19 | 0 | 198.0 | Nucleotide binding | ATP |
Hgene | GUK1 | chr1:228336098 | chrX:53228198 | ENST00000366730 | + | 1 | 8 | 171_172 | 0 | 198.0 | Nucleotide binding | ATP |
Hgene | GUK1 | chr1:228336098 | chrX:53228198 | ENST00000366730 | + | 1 | 8 | 37_51 | 0 | 198.0 | Nucleotide binding | Substrate binding |
Hgene | GUK1 | chr1:228336098 | chrX:53228198 | ENST00000391865 | + | 1 | 8 | 14_19 | 0 | 219.0 | Nucleotide binding | ATP |
Hgene | GUK1 | chr1:228336098 | chrX:53228198 | ENST00000391865 | + | 1 | 8 | 171_172 | 0 | 219.0 | Nucleotide binding | ATP |
Hgene | GUK1 | chr1:228336098 | chrX:53228198 | ENST00000391865 | + | 1 | 8 | 37_51 | 0 | 219.0 | Nucleotide binding | Substrate binding |
Top |
Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
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Gene | STRING network |
GUK1 | |
KDM5C |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs to GUK1-KDM5C |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to GUK1-KDM5C |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |