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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:GUK1-KDM5C

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: GUK1-KDM5C
FusionPDB ID: 35363
FusionGDB2.0 ID: 35363
HgeneTgene
Gene symbol

GUK1

KDM5C

Gene ID

2987

8242

Gene nameguanylate kinase 1lysine demethylase 5C
SynonymsGMKDXS1272E|JARID1C|MRX13|MRXJ|MRXSCJ|MRXSJ|SMCX|XE169
Cytomap

1q42.13

Xp11.22

Type of geneprotein-codingprotein-coding
Descriptionguanylate kinaseATP:GMP phosphotransferaseGMP kinaselysine-specific demethylase 5CJmjC domain-containing protein SMCXJumonji, AT rich interactive domain 1C (RBP2-like)Jumonji/ARID domain-containing protein 1CSmcx homolog, X chromosomeSmcy homolog, X-linkedhistone demethylase JARID1Clysine (K)-specif
Modification date2020032020200313
UniProtAcc

Q16774

P41229

Ensembl transtripts involved in fusion geneENST idsENST00000470040, ENST00000312726, 
ENST00000366716, ENST00000366718, 
ENST00000366721, ENST00000366722, 
ENST00000366723, ENST00000366726, 
ENST00000366730, ENST00000391865, 
ENST00000366728, 
ENST00000375379, 
ENST00000375383, ENST00000375401, 
ENST00000404049, ENST00000452825, 
ENST00000465402, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 13 X 6=10924 X 5 X 1=20
# samples 165
** MAII scorelog2(16/1092*10)=-2.77082904603249
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/20*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: GUK1 [Title/Abstract] AND KDM5C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GUK1(228336098)-KDM5C(53228198), # samples:1
Anticipated loss of major functional domain due to fusion event.GUK1-KDM5C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GUK1-KDM5C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GUK1-KDM5C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GUK1-KDM5C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GUK1-KDM5C seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
GUK1-KDM5C seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
GUK1-KDM5C seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
GUK1-KDM5C seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
GUK1-KDM5C seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
GUK1-KDM5C seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGUK1

GO:0006163

purine nucleotide metabolic process

8663313

HgeneGUK1

GO:0006805

xenobiotic metabolic process

6306664

TgeneKDM5C

GO:0034720

histone H3-K4 demethylation

17320160


check buttonFusion gene breakpoints across GUK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KDM5C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABE939838GUK1chr1

228336098

+KDM5CchrX

53228198

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000366730GUK1chr1228336098+ENST00000452825KDM5CchrX53228198+429573425053404299
ENST00000366730GUK1chr1228336098+ENST00000375401KDM5CchrX53228198+402973422393138299
ENST00000366730GUK1chr1228336098+ENST00000404049KDM5CchrX53228198+392473421343033299
ENST00000366730GUK1chr1228336098+ENST00000375379KDM5CchrX53228198+324373414532352299
ENST00000366730GUK1chr1228336098+ENST00000375383KDM5CchrX53228198+324373414532352299
ENST00000391865GUK1chr1228336098+ENST00000452825KDM5CchrX53228198+423367224433342299
ENST00000391865GUK1chr1228336098+ENST00000375401KDM5CchrX53228198+3967672361037333
ENST00000391865GUK1chr1228336098+ENST00000404049KDM5CchrX53228198+3862672361037333
ENST00000391865GUK1chr1228336098+ENST00000375379KDM5CchrX53228198+3181672361037333
ENST00000391865GUK1chr1228336098+ENST00000375383KDM5CchrX53228198+3181672361037333
ENST00000366726GUK1chr1228336098+ENST00000452825KDM5CchrX53228198+419163024013300299
ENST00000366726GUK1chr1228336098+ENST00000375401KDM5CchrX53228198+392563042995317
ENST00000366726GUK1chr1228336098+ENST00000404049KDM5CchrX53228198+382063042995317
ENST00000366726GUK1chr1228336098+ENST00000375379KDM5CchrX53228198+313963042995317
ENST00000366726GUK1chr1228336098+ENST00000375383KDM5CchrX53228198+313963042995317
ENST00000312726GUK1chr1228336098+ENST00000452825KDM5CchrX53228198+433677525463445299
ENST00000312726GUK1chr1228336098+ENST00000375401KDM5CchrX53228198+40707752051140311
ENST00000312726GUK1chr1228336098+ENST00000404049KDM5CchrX53228198+39657752051140311
ENST00000312726GUK1chr1228336098+ENST00000375379KDM5CchrX53228198+32847752051140311
ENST00000312726GUK1chr1228336098+ENST00000375383KDM5CchrX53228198+32847752051140311
ENST00000366721GUK1chr1228336098+ENST00000452825KDM5CchrX53228198+413557423453244299
ENST00000366721GUK1chr1228336098+ENST00000375401KDM5CchrX53228198+386957410939309
ENST00000366721GUK1chr1228336098+ENST00000404049KDM5CchrX53228198+376457410939309
ENST00000366721GUK1chr1228336098+ENST00000375379KDM5CchrX53228198+308357410939309
ENST00000366721GUK1chr1228336098+ENST00000375383KDM5CchrX53228198+308357410939309
ENST00000366718GUK1chr1228336098+ENST00000452825KDM5CchrX53228198+452296127323631299
ENST00000366718GUK1chr1228336098+ENST00000375401KDM5CchrX53228198+42569613941326310
ENST00000366718GUK1chr1228336098+ENST00000404049KDM5CchrX53228198+41519613941326310
ENST00000366718GUK1chr1228336098+ENST00000375379KDM5CchrX53228198+34709613941326310
ENST00000366718GUK1chr1228336098+ENST00000375383KDM5CchrX53228198+34709613941326310
ENST00000366716GUK1chr1228336098+ENST00000452825KDM5CchrX53228198+415459323643263299
ENST00000366716GUK1chr1228336098+ENST00000375401KDM5CchrX53228198+388859320982997299
ENST00000366716GUK1chr1228336098+ENST00000404049KDM5CchrX53228198+378359319932892299
ENST00000366716GUK1chr1228336098+ENST00000375379KDM5CchrX53228198+310259313122211299
ENST00000366716GUK1chr1228336098+ENST00000375383KDM5CchrX53228198+310259313122211299

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000366730ENST00000452825GUK1chr1228336098+KDM5CchrX53228198+0.0103152640.9896847
ENST00000366730ENST00000375401GUK1chr1228336098+KDM5CchrX53228198+0.0048224850.9951775
ENST00000366730ENST00000404049GUK1chr1228336098+KDM5CchrX53228198+0.0049161730.99508375
ENST00000366730ENST00000375379GUK1chr1228336098+KDM5CchrX53228198+0.0050249780.9949751
ENST00000366730ENST00000375383GUK1chr1228336098+KDM5CchrX53228198+0.0050249780.9949751
ENST00000391865ENST00000452825GUK1chr1228336098+KDM5CchrX53228198+0.0099469130.9900531
ENST00000391865ENST00000375401GUK1chr1228336098+KDM5CchrX53228198+0.0063891350.9936108
ENST00000391865ENST00000404049GUK1chr1228336098+KDM5CchrX53228198+0.0066631380.9933369
ENST00000391865ENST00000375379GUK1chr1228336098+KDM5CchrX53228198+0.007643330.99235666
ENST00000391865ENST00000375383GUK1chr1228336098+KDM5CchrX53228198+0.007643330.99235666
ENST00000366726ENST00000452825GUK1chr1228336098+KDM5CchrX53228198+0.0103122840.98968774
ENST00000366726ENST00000375401GUK1chr1228336098+KDM5CchrX53228198+0.0048917870.9951082
ENST00000366726ENST00000404049GUK1chr1228336098+KDM5CchrX53228198+0.0049812540.9950187
ENST00000366726ENST00000375379GUK1chr1228336098+KDM5CchrX53228198+0.005043270.9949568
ENST00000366726ENST00000375383GUK1chr1228336098+KDM5CchrX53228198+0.005043270.9949568
ENST00000312726ENST00000452825GUK1chr1228336098+KDM5CchrX53228198+0.0101796230.98982036
ENST00000312726ENST00000375401GUK1chr1228336098+KDM5CchrX53228198+0.004781880.9952181
ENST00000312726ENST00000404049GUK1chr1228336098+KDM5CchrX53228198+0.0048903460.9951096
ENST00000312726ENST00000375379GUK1chr1228336098+KDM5CchrX53228198+0.0049714880.99502856
ENST00000312726ENST00000375383GUK1chr1228336098+KDM5CchrX53228198+0.0049714880.99502856
ENST00000366721ENST00000452825GUK1chr1228336098+KDM5CchrX53228198+0.0102014640.98979855
ENST00000366721ENST00000375401GUK1chr1228336098+KDM5CchrX53228198+0.0051429080.9948571
ENST00000366721ENST00000404049GUK1chr1228336098+KDM5CchrX53228198+0.0053204580.9946795
ENST00000366721ENST00000375379GUK1chr1228336098+KDM5CchrX53228198+0.0055703970.9944296
ENST00000366721ENST00000375383GUK1chr1228336098+KDM5CchrX53228198+0.0055703970.9944296
ENST00000366718ENST00000452825GUK1chr1228336098+KDM5CchrX53228198+0.0108599730.98914003
ENST00000366718ENST00000375401GUK1chr1228336098+KDM5CchrX53228198+0.005252990.994747
ENST00000366718ENST00000404049GUK1chr1228336098+KDM5CchrX53228198+0.0053914440.9946085
ENST00000366718ENST00000375379GUK1chr1228336098+KDM5CchrX53228198+0.0055757860.9944243
ENST00000366718ENST00000375383GUK1chr1228336098+KDM5CchrX53228198+0.0055757860.9944243
ENST00000366716ENST00000452825GUK1chr1228336098+KDM5CchrX53228198+0.0098939010.99010617
ENST00000366716ENST00000375401GUK1chr1228336098+KDM5CchrX53228198+0.0049015830.9950984
ENST00000366716ENST00000404049GUK1chr1228336098+KDM5CchrX53228198+0.0050308380.9949692
ENST00000366716ENST00000375379GUK1chr1228336098+KDM5CchrX53228198+0.0047439640.995256
ENST00000366716ENST00000375383GUK1chr1228336098+KDM5CchrX53228198+0.0047439640.995256

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>35363_35363_1_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000312726_KDM5C_chrX_53228198_ENST00000375379_length(amino acids)=311AA_BP=
MWLWKSPISSGGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSG
NLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQA
YAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPST

--------------------------------------------------------------

>35363_35363_2_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000312726_KDM5C_chrX_53228198_ENST00000375383_length(amino acids)=311AA_BP=
MWLWKSPISSGGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSG
NLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQA
YAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPST

--------------------------------------------------------------

>35363_35363_3_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000312726_KDM5C_chrX_53228198_ENST00000375401_length(amino acids)=311AA_BP=
MWLWKSPISSGGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSG
NLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQA
YAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPST

--------------------------------------------------------------

>35363_35363_4_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000312726_KDM5C_chrX_53228198_ENST00000404049_length(amino acids)=311AA_BP=
MWLWKSPISSGGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSG
NLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQA
YAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPST

--------------------------------------------------------------

>35363_35363_5_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000312726_KDM5C_chrX_53228198_ENST00000452825_length(amino acids)=299AA_BP=212
MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR
RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG
KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH

--------------------------------------------------------------

>35363_35363_6_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366716_KDM5C_chrX_53228198_ENST00000375379_length(amino acids)=299AA_BP=212
MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR
RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG
KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH

--------------------------------------------------------------

>35363_35363_7_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366716_KDM5C_chrX_53228198_ENST00000375383_length(amino acids)=299AA_BP=212
MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR
RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG
KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH

--------------------------------------------------------------

>35363_35363_8_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366716_KDM5C_chrX_53228198_ENST00000375401_length(amino acids)=299AA_BP=212
MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR
RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG
KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH

--------------------------------------------------------------

>35363_35363_9_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366716_KDM5C_chrX_53228198_ENST00000404049_length(amino acids)=299AA_BP=212
MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR
RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG
KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH

--------------------------------------------------------------

>35363_35363_10_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366716_KDM5C_chrX_53228198_ENST00000452825_length(amino acids)=299AA_BP=212
MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR
RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG
KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH

--------------------------------------------------------------

>35363_35363_11_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366718_KDM5C_chrX_53228198_ENST00000375379_length(amino acids)=310AA_BP=
MTTEAAPQQTGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGN
LYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQAY
AELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQ

--------------------------------------------------------------

>35363_35363_12_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366718_KDM5C_chrX_53228198_ENST00000375383_length(amino acids)=310AA_BP=
MTTEAAPQQTGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGN
LYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQAY
AELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQ

--------------------------------------------------------------

>35363_35363_13_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366718_KDM5C_chrX_53228198_ENST00000375401_length(amino acids)=310AA_BP=
MTTEAAPQQTGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGN
LYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQAY
AELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQ

--------------------------------------------------------------

>35363_35363_14_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366718_KDM5C_chrX_53228198_ENST00000404049_length(amino acids)=310AA_BP=
MTTEAAPQQTGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGN
LYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQAY
AELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQ

--------------------------------------------------------------

>35363_35363_15_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366718_KDM5C_chrX_53228198_ENST00000452825_length(amino acids)=299AA_BP=212
MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR
RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG
KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH

--------------------------------------------------------------

>35363_35363_16_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366721_KDM5C_chrX_53228198_ENST00000375379_length(amino acids)=309AA_BP=
MGRAPPDGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSRESRALVEGYHEEPEARRGERQREVMQRDIAAGDFIEHAEFSGNL
YGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQAYA
ELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQE

--------------------------------------------------------------

>35363_35363_17_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366721_KDM5C_chrX_53228198_ENST00000375383_length(amino acids)=309AA_BP=
MGRAPPDGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSRESRALVEGYHEEPEARRGERQREVMQRDIAAGDFIEHAEFSGNL
YGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQAYA
ELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQE

--------------------------------------------------------------

>35363_35363_18_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366721_KDM5C_chrX_53228198_ENST00000375401_length(amino acids)=309AA_BP=
MGRAPPDGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSRESRALVEGYHEEPEARRGERQREVMQRDIAAGDFIEHAEFSGNL
YGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQAYA
ELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQE

--------------------------------------------------------------

>35363_35363_19_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366721_KDM5C_chrX_53228198_ENST00000404049_length(amino acids)=309AA_BP=
MGRAPPDGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSRESRALVEGYHEEPEARRGERQREVMQRDIAAGDFIEHAEFSGNL
YGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQAYA
ELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQE

--------------------------------------------------------------

>35363_35363_20_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366721_KDM5C_chrX_53228198_ENST00000452825_length(amino acids)=299AA_BP=212
MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR
RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG
KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH

--------------------------------------------------------------

>35363_35363_21_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366726_KDM5C_chrX_53228198_ENST00000375379_length(amino acids)=317AA_BP=
MRPPWAGPHRTPLFSPPGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIE
HAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIIN
DSLDQAYAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPT

--------------------------------------------------------------

>35363_35363_22_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366726_KDM5C_chrX_53228198_ENST00000375383_length(amino acids)=317AA_BP=
MRPPWAGPHRTPLFSPPGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIE
HAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIIN
DSLDQAYAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPT

--------------------------------------------------------------

>35363_35363_23_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366726_KDM5C_chrX_53228198_ENST00000375401_length(amino acids)=317AA_BP=
MRPPWAGPHRTPLFSPPGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIE
HAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIIN
DSLDQAYAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPT

--------------------------------------------------------------

>35363_35363_24_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366726_KDM5C_chrX_53228198_ENST00000404049_length(amino acids)=317AA_BP=
MRPPWAGPHRTPLFSPPGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIE
HAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIIN
DSLDQAYAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPT

--------------------------------------------------------------

>35363_35363_25_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366726_KDM5C_chrX_53228198_ENST00000452825_length(amino acids)=299AA_BP=212
MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR
RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG
KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH

--------------------------------------------------------------

>35363_35363_26_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366730_KDM5C_chrX_53228198_ENST00000375379_length(amino acids)=299AA_BP=212
MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR
RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG
KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH

--------------------------------------------------------------

>35363_35363_27_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366730_KDM5C_chrX_53228198_ENST00000375383_length(amino acids)=299AA_BP=212
MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR
RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG
KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH

--------------------------------------------------------------

>35363_35363_28_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366730_KDM5C_chrX_53228198_ENST00000375401_length(amino acids)=299AA_BP=212
MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR
RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG
KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH

--------------------------------------------------------------

>35363_35363_29_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366730_KDM5C_chrX_53228198_ENST00000404049_length(amino acids)=299AA_BP=212
MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR
RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG
KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH

--------------------------------------------------------------

>35363_35363_30_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366730_KDM5C_chrX_53228198_ENST00000452825_length(amino acids)=299AA_BP=212
MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR
RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG
KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH

--------------------------------------------------------------

>35363_35363_31_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000391865_KDM5C_chrX_53228198_ENST00000375379_length(amino acids)=333AA_BP=
MSRRFSGRKRWPRMLRRPLAGLAAAALGRAPPDGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFV
TREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLV
KRLAAAQADMESIIINDSLDQAYAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEE

--------------------------------------------------------------

>35363_35363_32_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000391865_KDM5C_chrX_53228198_ENST00000375383_length(amino acids)=333AA_BP=
MSRRFSGRKRWPRMLRRPLAGLAAAALGRAPPDGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFV
TREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLV
KRLAAAQADMESIIINDSLDQAYAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEE

--------------------------------------------------------------

>35363_35363_33_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000391865_KDM5C_chrX_53228198_ENST00000375401_length(amino acids)=333AA_BP=
MSRRFSGRKRWPRMLRRPLAGLAAAALGRAPPDGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFV
TREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLV
KRLAAAQADMESIIINDSLDQAYAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEE

--------------------------------------------------------------

>35363_35363_34_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000391865_KDM5C_chrX_53228198_ENST00000404049_length(amino acids)=333AA_BP=
MSRRFSGRKRWPRMLRRPLAGLAAAALGRAPPDGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFV
TREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLV
KRLAAAQADMESIIINDSLDQAYAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEE

--------------------------------------------------------------

>35363_35363_35_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000391865_KDM5C_chrX_53228198_ENST00000452825_length(amino acids)=299AA_BP=212
MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR
RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG
KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:228336098/chrX:53228198)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GUK1

Q16774

KDM5C

P41229

FUNCTION: Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) (PubMed:31201273). Involved in the cGMP metabolism in photoreceptors (By similarity). It may also have a role in the survival and growth progression of some tumors (PubMed:31201273). In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine (PubMed:197968, PubMed:6248551, PubMed:6306664). {ECO:0000250|UniProtKB:P46195, ECO:0000269|PubMed:197968, ECO:0000269|PubMed:31201273, ECO:0000269|PubMed:6248551, ECO:0000269|PubMed:6306664}.FUNCTION: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:28262558). Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:P41230, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17468742, ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:28262558}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKDM5Cchr1:228336098chrX:53228198ENST0000037537902614_5501558.0DomainJmjN
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000375379026468_63401558.0DomainJmjC
TgeneKDM5Cchr1:228336098chrX:53228198ENST0000037537902679_16901558.0DomainARID
TgeneKDM5Cchr1:228336098chrX:53228198ENST0000037538302514_5501517.0DomainJmjN
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000375383025468_63401517.0DomainJmjC
TgeneKDM5Cchr1:228336098chrX:53228198ENST0000037538302579_16901517.0DomainARID
TgeneKDM5Cchr1:228336098chrX:53228198ENST0000037540102614_5501561.0DomainJmjN
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000375401026468_63401561.0DomainJmjC
TgeneKDM5Cchr1:228336098chrX:53228198ENST0000037540102679_16901561.0DomainARID
TgeneKDM5Cchr1:228336098chrX:53228198ENST0000040404902614_5501560.0DomainJmjN
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000404049026468_63401560.0DomainJmjC
TgeneKDM5Cchr1:228336098chrX:53228198ENST0000040404902679_16901560.0DomainARID
TgeneKDM5Cchr1:228336098chrX:53228198ENST0000045282502414_5501380.0DomainJmjN
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000452825024468_63401380.0DomainJmjC
TgeneKDM5Cchr1:228336098chrX:53228198ENST0000045282502479_16901380.0DomainARID
TgeneKDM5Cchr1:228336098chrX:53228198ENST000003753790261187_124801558.0Zinc fingerPHD-type 2
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000375379026326_37201558.0Zinc fingerPHD-type 1
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000375379026707_75901558.0Zinc fingerC5HC2
TgeneKDM5Cchr1:228336098chrX:53228198ENST000003753830251187_124801517.0Zinc fingerPHD-type 2
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000375383025326_37201517.0Zinc fingerPHD-type 1
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000375383025707_75901517.0Zinc fingerC5HC2
TgeneKDM5Cchr1:228336098chrX:53228198ENST000003754010261187_124801561.0Zinc fingerPHD-type 2
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000375401026326_37201561.0Zinc fingerPHD-type 1
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000375401026707_75901561.0Zinc fingerC5HC2
TgeneKDM5Cchr1:228336098chrX:53228198ENST000004040490261187_124801560.0Zinc fingerPHD-type 2
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000404049026326_37201560.0Zinc fingerPHD-type 1
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000404049026707_75901560.0Zinc fingerC5HC2
TgeneKDM5Cchr1:228336098chrX:53228198ENST000004528250241187_124801380.0Zinc fingerPHD-type 2
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000452825024326_37201380.0Zinc fingerPHD-type 1
TgeneKDM5Cchr1:228336098chrX:53228198ENST00000452825024707_75901380.0Zinc fingerC5HC2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGUK1chr1:228336098chrX:53228198ENST00000312726+194_1860198.0DomainGuanylate kinase-like
HgeneGUK1chr1:228336098chrX:53228198ENST00000366716+174_1860198.0DomainGuanylate kinase-like
HgeneGUK1chr1:228336098chrX:53228198ENST00000366718+184_1860198.0DomainGuanylate kinase-like
HgeneGUK1chr1:228336098chrX:53228198ENST00000366726+184_1860198.0DomainGuanylate kinase-like
HgeneGUK1chr1:228336098chrX:53228198ENST00000366728+174_1860242.0DomainGuanylate kinase-like
HgeneGUK1chr1:228336098chrX:53228198ENST00000366730+184_1860198.0DomainGuanylate kinase-like
HgeneGUK1chr1:228336098chrX:53228198ENST00000391865+184_1860219.0DomainGuanylate kinase-like
HgeneGUK1chr1:228336098chrX:53228198ENST00000312726+1914_190198.0Nucleotide bindingATP
HgeneGUK1chr1:228336098chrX:53228198ENST00000312726+19171_1720198.0Nucleotide bindingATP
HgeneGUK1chr1:228336098chrX:53228198ENST00000312726+1937_510198.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228336098chrX:53228198ENST00000366716+1714_190198.0Nucleotide bindingATP
HgeneGUK1chr1:228336098chrX:53228198ENST00000366716+17171_1720198.0Nucleotide bindingATP
HgeneGUK1chr1:228336098chrX:53228198ENST00000366716+1737_510198.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228336098chrX:53228198ENST00000366718+1814_190198.0Nucleotide bindingATP
HgeneGUK1chr1:228336098chrX:53228198ENST00000366718+18171_1720198.0Nucleotide bindingATP
HgeneGUK1chr1:228336098chrX:53228198ENST00000366718+1837_510198.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228336098chrX:53228198ENST00000366726+1814_190198.0Nucleotide bindingATP
HgeneGUK1chr1:228336098chrX:53228198ENST00000366726+18171_1720198.0Nucleotide bindingATP
HgeneGUK1chr1:228336098chrX:53228198ENST00000366726+1837_510198.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228336098chrX:53228198ENST00000366728+1714_190242.0Nucleotide bindingATP
HgeneGUK1chr1:228336098chrX:53228198ENST00000366728+17171_1720242.0Nucleotide bindingATP
HgeneGUK1chr1:228336098chrX:53228198ENST00000366728+1737_510242.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228336098chrX:53228198ENST00000366730+1814_190198.0Nucleotide bindingATP
HgeneGUK1chr1:228336098chrX:53228198ENST00000366730+18171_1720198.0Nucleotide bindingATP
HgeneGUK1chr1:228336098chrX:53228198ENST00000366730+1837_510198.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228336098chrX:53228198ENST00000391865+1814_190219.0Nucleotide bindingATP
HgeneGUK1chr1:228336098chrX:53228198ENST00000391865+18171_1720219.0Nucleotide bindingATP
HgeneGUK1chr1:228336098chrX:53228198ENST00000391865+1837_510219.0Nucleotide bindingSubstrate binding


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
GUK1
KDM5C


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to GUK1-KDM5C


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to GUK1-KDM5C


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource