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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:GUK1-KDM5C

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: GUK1-KDM5C
	FusionPDB ID: 35363
	FusionGDB2.0 ID: 35363
		Hgene	Tgene
	Gene symbol	GUK1	KDM5C
	Gene ID	2987	8242
	Gene name	guanylate kinase 1	lysine demethylase 5C
	Synonyms	GMK	DXS1272E\|JARID1C\|MRX13\|MRXJ\|MRXSCJ\|MRXSJ\|SMCX\|XE169
	Cytomap	1q42.13	Xp11.22
	Type of gene	protein-coding	protein-coding
	Description	guanylate kinaseATP:GMP phosphotransferaseGMP kinase	lysine-specific demethylase 5CJmjC domain-containing protein SMCXJumonji, AT rich interactive domain 1C (RBP2-like)Jumonji/ARID domain-containing protein 1CSmcx homolog, X chromosomeSmcy homolog, X-linkedhistone demethylase JARID1Clysine (K)-specif
	Modification date	20200320	20200313
	UniProtAcc	Q16774	P41229
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000470040, ENST00000312726, ENST00000366716, ENST00000366718, ENST00000366721, ENST00000366722, ENST00000366723, ENST00000366726, ENST00000366730, ENST00000391865, ENST00000366728,	ENST00000375379, ENST00000375383, ENST00000375401, ENST00000404049, ENST00000452825, ENST00000465402,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	14 X 13 X 6=1092	4 X 5 X 1=20
	# samples	16	5
	** MAII score	log2(16/1092*10)=-2.77082904603249 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/20*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: GUK1 [Title/Abstract] AND KDM5C [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	GUK1(228336098)-KDM5C(53228198), # samples:1
Anticipated loss of major functional domain due to fusion event.	GUK1-KDM5C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GUK1-KDM5C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GUK1-KDM5C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. GUK1-KDM5C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. GUK1-KDM5C seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. GUK1-KDM5C seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. GUK1-KDM5C seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. GUK1-KDM5C seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. GUK1-KDM5C seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. GUK1-KDM5C seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GUK1	GO:0006163	purine nucleotide metabolic process	8663313
Hgene	GUK1	GO:0006805	xenobiotic metabolic process	6306664
Tgene	KDM5C	GO:0034720	histone H3-K4 demethylation	17320160

Fusion gene breakpoints across GUK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KDM5C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BE939838	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000366730	GUK1	chr1	228336098	+	ENST00000452825	KDM5C	chrX	53228198	+	4295	734	2505	3404	299
ENST00000366730	GUK1	chr1	228336098	+	ENST00000375401	KDM5C	chrX	53228198	+	4029	734	2239	3138	299
ENST00000366730	GUK1	chr1	228336098	+	ENST00000404049	KDM5C	chrX	53228198	+	3924	734	2134	3033	299
ENST00000366730	GUK1	chr1	228336098	+	ENST00000375379	KDM5C	chrX	53228198	+	3243	734	1453	2352	299
ENST00000366730	GUK1	chr1	228336098	+	ENST00000375383	KDM5C	chrX	53228198	+	3243	734	1453	2352	299
ENST00000391865	GUK1	chr1	228336098	+	ENST00000452825	KDM5C	chrX	53228198	+	4233	672	2443	3342	299
ENST00000391865	GUK1	chr1	228336098	+	ENST00000375401	KDM5C	chrX	53228198	+	3967	672	36	1037	333
ENST00000391865	GUK1	chr1	228336098	+	ENST00000404049	KDM5C	chrX	53228198	+	3862	672	36	1037	333
ENST00000391865	GUK1	chr1	228336098	+	ENST00000375379	KDM5C	chrX	53228198	+	3181	672	36	1037	333
ENST00000391865	GUK1	chr1	228336098	+	ENST00000375383	KDM5C	chrX	53228198	+	3181	672	36	1037	333
ENST00000366726	GUK1	chr1	228336098	+	ENST00000452825	KDM5C	chrX	53228198	+	4191	630	2401	3300	299
ENST00000366726	GUK1	chr1	228336098	+	ENST00000375401	KDM5C	chrX	53228198	+	3925	630	42	995	317
ENST00000366726	GUK1	chr1	228336098	+	ENST00000404049	KDM5C	chrX	53228198	+	3820	630	42	995	317
ENST00000366726	GUK1	chr1	228336098	+	ENST00000375379	KDM5C	chrX	53228198	+	3139	630	42	995	317
ENST00000366726	GUK1	chr1	228336098	+	ENST00000375383	KDM5C	chrX	53228198	+	3139	630	42	995	317
ENST00000312726	GUK1	chr1	228336098	+	ENST00000452825	KDM5C	chrX	53228198	+	4336	775	2546	3445	299
ENST00000312726	GUK1	chr1	228336098	+	ENST00000375401	KDM5C	chrX	53228198	+	4070	775	205	1140	311
ENST00000312726	GUK1	chr1	228336098	+	ENST00000404049	KDM5C	chrX	53228198	+	3965	775	205	1140	311
ENST00000312726	GUK1	chr1	228336098	+	ENST00000375379	KDM5C	chrX	53228198	+	3284	775	205	1140	311
ENST00000312726	GUK1	chr1	228336098	+	ENST00000375383	KDM5C	chrX	53228198	+	3284	775	205	1140	311
ENST00000366721	GUK1	chr1	228336098	+	ENST00000452825	KDM5C	chrX	53228198	+	4135	574	2345	3244	299
ENST00000366721	GUK1	chr1	228336098	+	ENST00000375401	KDM5C	chrX	53228198	+	3869	574	10	939	309
ENST00000366721	GUK1	chr1	228336098	+	ENST00000404049	KDM5C	chrX	53228198	+	3764	574	10	939	309
ENST00000366721	GUK1	chr1	228336098	+	ENST00000375379	KDM5C	chrX	53228198	+	3083	574	10	939	309
ENST00000366721	GUK1	chr1	228336098	+	ENST00000375383	KDM5C	chrX	53228198	+	3083	574	10	939	309
ENST00000366718	GUK1	chr1	228336098	+	ENST00000452825	KDM5C	chrX	53228198	+	4522	961	2732	3631	299
ENST00000366718	GUK1	chr1	228336098	+	ENST00000375401	KDM5C	chrX	53228198	+	4256	961	394	1326	310
ENST00000366718	GUK1	chr1	228336098	+	ENST00000404049	KDM5C	chrX	53228198	+	4151	961	394	1326	310
ENST00000366718	GUK1	chr1	228336098	+	ENST00000375379	KDM5C	chrX	53228198	+	3470	961	394	1326	310
ENST00000366718	GUK1	chr1	228336098	+	ENST00000375383	KDM5C	chrX	53228198	+	3470	961	394	1326	310
ENST00000366716	GUK1	chr1	228336098	+	ENST00000452825	KDM5C	chrX	53228198	+	4154	593	2364	3263	299
ENST00000366716	GUK1	chr1	228336098	+	ENST00000375401	KDM5C	chrX	53228198	+	3888	593	2098	2997	299
ENST00000366716	GUK1	chr1	228336098	+	ENST00000404049	KDM5C	chrX	53228198	+	3783	593	1993	2892	299
ENST00000366716	GUK1	chr1	228336098	+	ENST00000375379	KDM5C	chrX	53228198	+	3102	593	1312	2211	299
ENST00000366716	GUK1	chr1	228336098	+	ENST00000375383	KDM5C	chrX	53228198	+	3102	593	1312	2211	299

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000366730	ENST00000452825	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.010315264	0.9896847
ENST00000366730	ENST00000375401	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.004822485	0.9951775
ENST00000366730	ENST00000404049	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.004916173	0.99508375
ENST00000366730	ENST00000375379	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.005024978	0.9949751
ENST00000366730	ENST00000375383	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.005024978	0.9949751
ENST00000391865	ENST00000452825	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.009946913	0.9900531
ENST00000391865	ENST00000375401	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.006389135	0.9936108
ENST00000391865	ENST00000404049	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.006663138	0.9933369
ENST00000391865	ENST00000375379	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.00764333	0.99235666
ENST00000391865	ENST00000375383	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.00764333	0.99235666
ENST00000366726	ENST00000452825	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.010312284	0.98968774
ENST00000366726	ENST00000375401	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.004891787	0.9951082
ENST00000366726	ENST00000404049	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.004981254	0.9950187
ENST00000366726	ENST00000375379	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.00504327	0.9949568
ENST00000366726	ENST00000375383	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.00504327	0.9949568
ENST00000312726	ENST00000452825	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.010179623	0.98982036
ENST00000312726	ENST00000375401	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.00478188	0.9952181
ENST00000312726	ENST00000404049	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.004890346	0.9951096
ENST00000312726	ENST00000375379	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.004971488	0.99502856
ENST00000312726	ENST00000375383	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.004971488	0.99502856
ENST00000366721	ENST00000452825	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.010201464	0.98979855
ENST00000366721	ENST00000375401	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.005142908	0.9948571
ENST00000366721	ENST00000404049	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.005320458	0.9946795
ENST00000366721	ENST00000375379	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.005570397	0.9944296
ENST00000366721	ENST00000375383	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.005570397	0.9944296
ENST00000366718	ENST00000452825	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.010859973	0.98914003
ENST00000366718	ENST00000375401	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.00525299	0.994747
ENST00000366718	ENST00000404049	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.005391444	0.9946085
ENST00000366718	ENST00000375379	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.005575786	0.9944243
ENST00000366718	ENST00000375383	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.005575786	0.9944243
ENST00000366716	ENST00000452825	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.009893901	0.99010617
ENST00000366716	ENST00000375401	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.004901583	0.9950984
ENST00000366716	ENST00000404049	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.005030838	0.9949692
ENST00000366716	ENST00000375379	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.004743964	0.995256
ENST00000366716	ENST00000375383	GUK1	chr1	228336098	+	KDM5C	chrX	53228198	+	0.004743964	0.995256

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>35363_35363_1_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000312726_KDM5C_chrX_53228198_ENST00000375379_length(amino acids)=311AA_BP=
MWLWKSPISSGGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSG
NLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQA
YAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPST

--------------------------------------------------------------

>35363_35363_2_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000312726_KDM5C_chrX_53228198_ENST00000375383_length(amino acids)=311AA_BP=
MWLWKSPISSGGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSG
NLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQA
YAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPST

--------------------------------------------------------------

>35363_35363_3_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000312726_KDM5C_chrX_53228198_ENST00000375401_length(amino acids)=311AA_BP=
MWLWKSPISSGGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSG
NLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQA
YAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPST

--------------------------------------------------------------

>35363_35363_4_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000312726_KDM5C_chrX_53228198_ENST00000404049_length(amino acids)=311AA_BP=
MWLWKSPISSGGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSG
NLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQA
YAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPST

--------------------------------------------------------------

>35363_35363_5_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000312726_KDM5C_chrX_53228198_ENST00000452825_length(amino acids)=299AA_BP=212
MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR
RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG
KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH

--------------------------------------------------------------

>35363_35363_6_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366716_KDM5C_chrX_53228198_ENST00000375379_length(amino acids)=299AA_BP=212
MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR
RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG
KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH

--------------------------------------------------------------

>35363_35363_7_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366716_KDM5C_chrX_53228198_ENST00000375383_length(amino acids)=299AA_BP=212
MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR
RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG
KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH

--------------------------------------------------------------

>35363_35363_8_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366716_KDM5C_chrX_53228198_ENST00000375401_length(amino acids)=299AA_BP=212
MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR
RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG
KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH

--------------------------------------------------------------

>35363_35363_9_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366716_KDM5C_chrX_53228198_ENST00000404049_length(amino acids)=299AA_BP=212
MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR
RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG
KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH

--------------------------------------------------------------

>35363_35363_10_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366716_KDM5C_chrX_53228198_ENST00000452825_length(amino acids)=299AA_BP=212
MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR
RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG
KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH

--------------------------------------------------------------

>35363_35363_11_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366718_KDM5C_chrX_53228198_ENST00000375379_length(amino acids)=310AA_BP=
MTTEAAPQQTGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGN
LYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQAY
AELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQ

--------------------------------------------------------------

>35363_35363_12_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366718_KDM5C_chrX_53228198_ENST00000375383_length(amino acids)=310AA_BP=
MTTEAAPQQTGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGN
LYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQAY
AELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQ

--------------------------------------------------------------

>35363_35363_13_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366718_KDM5C_chrX_53228198_ENST00000375401_length(amino acids)=310AA_BP=
MTTEAAPQQTGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGN
LYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQAY
AELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQ

--------------------------------------------------------------

>35363_35363_14_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366718_KDM5C_chrX_53228198_ENST00000404049_length(amino acids)=310AA_BP=
MTTEAAPQQTGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGN
LYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQAY
AELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQ

--------------------------------------------------------------

>35363_35363_15_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366718_KDM5C_chrX_53228198_ENST00000452825_length(amino acids)=299AA_BP=212
MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR
RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG
KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH

--------------------------------------------------------------

>35363_35363_16_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366721_KDM5C_chrX_53228198_ENST00000375379_length(amino acids)=309AA_BP=
MGRAPPDGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSRESRALVEGYHEEPEARRGERQREVMQRDIAAGDFIEHAEFSGNL
YGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQAYA
ELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQE

--------------------------------------------------------------

>35363_35363_17_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366721_KDM5C_chrX_53228198_ENST00000375383_length(amino acids)=309AA_BP=
MGRAPPDGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSRESRALVEGYHEEPEARRGERQREVMQRDIAAGDFIEHAEFSGNL
YGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQAYA
ELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQE

--------------------------------------------------------------

>35363_35363_18_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366721_KDM5C_chrX_53228198_ENST00000375401_length(amino acids)=309AA_BP=
MGRAPPDGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSRESRALVEGYHEEPEARRGERQREVMQRDIAAGDFIEHAEFSGNL
YGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQAYA
ELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQE

--------------------------------------------------------------

>35363_35363_19_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366721_KDM5C_chrX_53228198_ENST00000404049_length(amino acids)=309AA_BP=
MGRAPPDGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSRESRALVEGYHEEPEARRGERQREVMQRDIAAGDFIEHAEFSGNL
YGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIINDSLDQAYA
ELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQE

--------------------------------------------------------------

>35363_35363_20_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366721_KDM5C_chrX_53228198_ENST00000452825_length(amino acids)=299AA_BP=212
MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR
RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG
KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH

--------------------------------------------------------------

>35363_35363_21_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366726_KDM5C_chrX_53228198_ENST00000375379_length(amino acids)=317AA_BP=
MRPPWAGPHRTPLFSPPGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIE
HAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIIN
DSLDQAYAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPT

--------------------------------------------------------------

>35363_35363_22_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366726_KDM5C_chrX_53228198_ENST00000375383_length(amino acids)=317AA_BP=
MRPPWAGPHRTPLFSPPGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIE
HAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIIN
DSLDQAYAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPT

--------------------------------------------------------------

>35363_35363_23_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366726_KDM5C_chrX_53228198_ENST00000375401_length(amino acids)=317AA_BP=
MRPPWAGPHRTPLFSPPGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIE
HAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIIN
DSLDQAYAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPT

--------------------------------------------------------------

>35363_35363_24_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366726_KDM5C_chrX_53228198_ENST00000404049_length(amino acids)=317AA_BP=
MRPPWAGPHRTPLFSPPGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIE
HAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESIIIN
DSLDQAYAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPT

--------------------------------------------------------------

>35363_35363_25_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366726_KDM5C_chrX_53228198_ENST00000452825_length(amino acids)=299AA_BP=212
MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR
RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG
KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH

--------------------------------------------------------------

>35363_35363_26_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366730_KDM5C_chrX_53228198_ENST00000375379_length(amino acids)=299AA_BP=212
MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR
RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG
KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH

--------------------------------------------------------------

>35363_35363_27_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366730_KDM5C_chrX_53228198_ENST00000375383_length(amino acids)=299AA_BP=212
MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR
RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG
KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH

--------------------------------------------------------------

>35363_35363_28_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366730_KDM5C_chrX_53228198_ENST00000375401_length(amino acids)=299AA_BP=212
MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR
RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG
KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH

--------------------------------------------------------------

>35363_35363_29_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366730_KDM5C_chrX_53228198_ENST00000404049_length(amino acids)=299AA_BP=212
MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR
RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG
KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH

--------------------------------------------------------------

>35363_35363_30_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000366730_KDM5C_chrX_53228198_ENST00000452825_length(amino acids)=299AA_BP=212
MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR
RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG
KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH

--------------------------------------------------------------

>35363_35363_31_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000391865_KDM5C_chrX_53228198_ENST00000375379_length(amino acids)=333AA_BP=
MSRRFSGRKRWPRMLRRPLAGLAAAALGRAPPDGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFV
TREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLV
KRLAAAQADMESIIINDSLDQAYAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEE

--------------------------------------------------------------

>35363_35363_32_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000391865_KDM5C_chrX_53228198_ENST00000375383_length(amino acids)=333AA_BP=
MSRRFSGRKRWPRMLRRPLAGLAAAALGRAPPDGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFV
TREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLV
KRLAAAQADMESIIINDSLDQAYAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEE

--------------------------------------------------------------

>35363_35363_33_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000391865_KDM5C_chrX_53228198_ENST00000375401_length(amino acids)=333AA_BP=
MSRRFSGRKRWPRMLRRPLAGLAAAALGRAPPDGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFV
TREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLV
KRLAAAQADMESIIINDSLDQAYAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEE

--------------------------------------------------------------

>35363_35363_34_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000391865_KDM5C_chrX_53228198_ENST00000404049_length(amino acids)=333AA_BP=
MSRRFSGRKRWPRMLRRPLAGLAAAALGRAPPDGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFV
TREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLV
KRLAAAQADMESIIINDSLDQAYAELKEALSELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEE

--------------------------------------------------------------

>35363_35363_35_GUK1-KDM5C_GUK1_chr1_228336098_ENST00000391865_KDM5C_chrX_53228198_ENST00000452825_length(amino acids)=299AA_BP=212
MQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSR
RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSG
KDMPKVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAH

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:228336098/chrX:53228198)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GUK1 Q16774	KDM5C P41229
FUNCTION: Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) (PubMed:31201273). Involved in the cGMP metabolism in photoreceptors (By similarity). It may also have a role in the survival and growth progression of some tumors (PubMed:31201273). In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine (PubMed:197968, PubMed:6248551, PubMed:6306664). {ECO:0000250\|UniProtKB:P46195, ECO:0000269\|PubMed:197968, ECO:0000269\|PubMed:31201273, ECO:0000269\|PubMed:6248551, ECO:0000269\|PubMed:6306664}.	FUNCTION: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:28262558). Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250\|UniProtKB:P41230, ECO:0000269\|PubMed:17320160, ECO:0000269\|PubMed:17320161, ECO:0000269\|PubMed:17468742, ECO:0000269\|PubMed:26645689, ECO:0000269\|PubMed:28262558}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

KDM5C

chr1:228336098

chrX:53228198

ENST00000375379

14_55

1558.0

Domain

JmjN

Tgene

KDM5C

chr1:228336098

chrX:53228198

ENST00000375379

468_634

1558.0

Domain

JmjC

Tgene

KDM5C

chr1:228336098

chrX:53228198

ENST00000375379

79_169

1558.0

Domain

ARID

Tgene

KDM5C

chr1:228336098

chrX:53228198

ENST00000375383

14_55

1517.0

Domain

JmjN

Tgene

KDM5C

chr1:228336098

chrX:53228198

ENST00000375383

468_634

1517.0

Domain

JmjC

Tgene

KDM5C

chr1:228336098

chrX:53228198

ENST00000375383

79_169

1517.0

Domain

ARID

Tgene

KDM5C

chr1:228336098

chrX:53228198

ENST00000375401

14_55

1561.0

Domain

JmjN

Tgene

KDM5C

chr1:228336098

chrX:53228198

ENST00000375401

468_634

1561.0

Domain

JmjC

Tgene

KDM5C

chr1:228336098

chrX:53228198

ENST00000375401

79_169

1561.0

Domain

ARID

Tgene

KDM5C

chr1:228336098

chrX:53228198

ENST00000404049

14_55

1560.0

Domain

JmjN

Tgene

KDM5C

chr1:228336098

chrX:53228198

ENST00000404049

468_634

1560.0

Domain

JmjC

Tgene

KDM5C

chr1:228336098

chrX:53228198

ENST00000404049

79_169

1560.0

Domain

ARID

Tgene

KDM5C

chr1:228336098

chrX:53228198

ENST00000452825

14_55

1380.0

Domain

JmjN

Tgene

KDM5C

chr1:228336098

chrX:53228198

ENST00000452825

468_634

1380.0

Domain

JmjC

Tgene

KDM5C

chr1:228336098

chrX:53228198

ENST00000452825

79_169

1380.0

Domain

ARID

Tgene

KDM5C

chr1:228336098

chrX:53228198

ENST00000375379

1187_1248

1558.0

Zinc finger

PHD-type 2

Tgene

KDM5C

chr1:228336098

chrX:53228198

ENST00000375379

326_372

1558.0

Zinc finger

PHD-type 1

Tgene

KDM5C

chr1:228336098

chrX:53228198

ENST00000375379

707_759

1558.0

Zinc finger

C5HC2

Tgene

KDM5C

chr1:228336098

chrX:53228198

ENST00000375383

1187_1248

1517.0

Zinc finger

PHD-type 2

Tgene

KDM5C

chr1:228336098

chrX:53228198

ENST00000375383

326_372

1517.0

Zinc finger

PHD-type 1

Tgene

KDM5C

chr1:228336098

chrX:53228198

ENST00000375383

707_759

1517.0

Zinc finger

C5HC2

Tgene

KDM5C

chr1:228336098

chrX:53228198

ENST00000375401

1187_1248

1561.0

Zinc finger

PHD-type 2

Tgene

KDM5C

chr1:228336098

chrX:53228198

ENST00000375401

326_372

1561.0

Zinc finger

PHD-type 1

Tgene

KDM5C

chr1:228336098

chrX:53228198

ENST00000375401

707_759

1561.0

Zinc finger

C5HC2

Tgene

KDM5C

chr1:228336098

chrX:53228198

ENST00000404049

1187_1248

1560.0

Zinc finger

PHD-type 2

Tgene

KDM5C

chr1:228336098

chrX:53228198

ENST00000404049

326_372

1560.0

Zinc finger

PHD-type 1

Tgene

KDM5C

chr1:228336098

chrX:53228198

ENST00000404049

707_759

1560.0

Zinc finger

C5HC2

Tgene

KDM5C

chr1:228336098

chrX:53228198

ENST00000452825

1187_1248

1380.0

Zinc finger

PHD-type 2

Tgene

KDM5C

chr1:228336098

chrX:53228198

ENST00000452825

326_372

1380.0

Zinc finger

PHD-type 1

Tgene

KDM5C

chr1:228336098

chrX:53228198

ENST00000452825

707_759

1380.0

Zinc finger

C5HC2

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GUK1

chr1:228336098

chrX:53228198

ENST00000312726

4_186

198.0

Domain

Guanylate kinase-like

Hgene

GUK1

chr1:228336098

chrX:53228198

ENST00000366716

4_186

198.0

Domain

Guanylate kinase-like

Hgene

GUK1

chr1:228336098

chrX:53228198

ENST00000366718

4_186

198.0

Domain

Guanylate kinase-like

Hgene

GUK1

chr1:228336098

chrX:53228198

ENST00000366726

4_186

198.0

Domain

Guanylate kinase-like

Hgene

GUK1

chr1:228336098

chrX:53228198

ENST00000366728

4_186

242.0

Domain

Guanylate kinase-like

Hgene

GUK1

chr1:228336098

chrX:53228198

ENST00000366730

4_186

198.0

Domain

Guanylate kinase-like

Hgene

GUK1

chr1:228336098

chrX:53228198

ENST00000391865

4_186

219.0

Domain

Guanylate kinase-like

Hgene

GUK1

chr1:228336098

chrX:53228198

ENST00000312726

14_19

198.0

Nucleotide binding

ATP

Hgene

GUK1

chr1:228336098

chrX:53228198

ENST00000312726

171_172

198.0

Nucleotide binding

ATP

Hgene

GUK1

chr1:228336098

chrX:53228198

ENST00000312726

37_51

198.0

Nucleotide binding

Substrate binding

Hgene

GUK1

chr1:228336098

chrX:53228198

ENST00000366716

14_19

198.0

Nucleotide binding

ATP

Hgene

GUK1

chr1:228336098

chrX:53228198

ENST00000366716

171_172

198.0

Nucleotide binding

ATP

Hgene

GUK1

chr1:228336098

chrX:53228198

ENST00000366716

37_51

198.0

Nucleotide binding

Substrate binding

Hgene

GUK1

chr1:228336098

chrX:53228198

ENST00000366718

14_19

198.0

Nucleotide binding

ATP

Hgene

GUK1

chr1:228336098

chrX:53228198

ENST00000366718

171_172

198.0

Nucleotide binding

ATP

Hgene

GUK1

chr1:228336098

chrX:53228198

ENST00000366718

37_51

198.0

Nucleotide binding

Substrate binding

Hgene

GUK1

chr1:228336098

chrX:53228198

ENST00000366726

14_19

198.0

Nucleotide binding

ATP

Hgene

GUK1

chr1:228336098

chrX:53228198

ENST00000366726

171_172

198.0

Nucleotide binding

ATP

Hgene

GUK1

chr1:228336098

chrX:53228198

ENST00000366726

37_51

198.0

Nucleotide binding

Substrate binding

Hgene

GUK1

chr1:228336098

chrX:53228198

ENST00000366728

14_19

242.0

Nucleotide binding

ATP

Hgene

GUK1

chr1:228336098

chrX:53228198

ENST00000366728

171_172

242.0

Nucleotide binding

ATP

Hgene

GUK1

chr1:228336098

chrX:53228198

ENST00000366728

37_51

242.0

Nucleotide binding

Substrate binding

Hgene

GUK1

chr1:228336098

chrX:53228198

ENST00000366730

14_19

198.0

Nucleotide binding

ATP

Hgene

GUK1

chr1:228336098

chrX:53228198

ENST00000366730

171_172

198.0

Nucleotide binding

ATP

Hgene

GUK1

chr1:228336098

chrX:53228198

ENST00000366730

37_51

198.0

Nucleotide binding

Substrate binding

Hgene

GUK1

chr1:228336098

chrX:53228198

ENST00000391865

14_19

219.0

Nucleotide binding

ATP

Hgene

GUK1

chr1:228336098

chrX:53228198

ENST00000391865

171_172

219.0

Nucleotide binding

ATP

Hgene

GUK1

chr1:228336098

chrX:53228198

ENST00000391865

37_51

219.0

Nucleotide binding

Substrate binding

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
GUK1
KDM5C

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to GUK1-KDM5C

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to GUK1-KDM5C

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source