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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:HACE1-ASCC3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: HACE1-ASCC3
FusionPDB ID: 35554
FusionGDB2.0 ID: 35554
HgeneTgene
Gene symbol

HACE1

ASCC3

Gene ID

57531

10973

Gene nameHECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1activating signal cointegrator 1 complex subunit 3
SynonymsSPPRSASC1p200|HELIC1|RNAH
Cytomap

6q16.3

6q16.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase HACE1HECT-type E3 ubiquitin transferase HACE1activating signal cointegrator 1 complex subunit 3ASC-1 complex subunit P200RNA helicase familyhelicase, ATP binding 1trip4 complex subunit p200
Modification date2020031320200313
UniProtAcc

Q8IYU2

Q8N3C0

Ensembl transtripts involved in fusion geneENST idsENST00000262903, ENST00000369125, 
ENST00000517995, 		ENST00000369143, 
ENST00000369162, ENST00000522650, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 4 X 4=6414 X 10 X 11=1540
# samples 418
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1540*10)=-3.09686153925259
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: HACE1 [Title/Abstract] AND ASCC3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)HACE1(105291098)-ASCC3(101312090), # samples:1
Anticipated loss of major functional domain due to fusion event.HACE1-ASCC3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HACE1-ASCC3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HACE1-ASCC3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HACE1-ASCC3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHACE1

GO:0006511

ubiquitin-dependent protein catabolic process

22036506

HgeneHACE1

GO:0007030

Golgi organization

21988917

HgeneHACE1

GO:0016567

protein ubiquitination

21988917

HgeneHACE1

GO:0070936

protein K48-linked ubiquitination

22036506

TgeneASCC3

GO:0006307

DNA dealkylation involved in DNA repair

22055184

TgeneASCC3

GO:0032508

DNA duplex unwinding

22055184


check buttonFusion gene breakpoints across HACE1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ASCC3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-46-6026-01AHACE1chr6

105291098

-ASCC3chr6

101312090

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262903HACE1chr6105291098-ENST00000369162ASCC3chr6101312090-839067927771972306
ENST00000262903HACE1chr6105291098-ENST00000522650ASCC3chr6101312090-30726792772784835
ENST00000262903HACE1chr6105291098-ENST00000369143ASCC3chr6101312090-3730679277924215
ENST00000369125HACE1chr6105291098-ENST00000369162ASCC3chr6101312090-839067927771972306
ENST00000369125HACE1chr6105291098-ENST00000522650ASCC3chr6101312090-30726792772784835
ENST00000369125HACE1chr6105291098-ENST00000369143ASCC3chr6101312090-3730679277924215

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262903ENST00000369162HACE1chr6105291098-ASCC3chr6101312090-0.0006701440.9993299
ENST00000262903ENST00000522650HACE1chr6105291098-ASCC3chr6101312090-0.0010278480.9989722
ENST00000262903ENST00000369143HACE1chr6105291098-ASCC3chr6101312090-0.0012999220.9987
ENST00000369125ENST00000369162HACE1chr6105291098-ASCC3chr6101312090-0.0006701440.9993299
ENST00000369125ENST00000522650HACE1chr6105291098-ASCC3chr6101312090-0.0010278480.9989722
ENST00000369125ENST00000369143HACE1chr6105291098-ASCC3chr6101312090-0.0012999220.9987

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>35554_35554_1_HACE1-ASCC3_HACE1_chr6_105291098_ENST00000262903_ASCC3_chr6_101312090_ENST00000369143_length(amino acids)=215AA_BP=134
MERAMEQLNRLTRSLRRARTVELPEDNETAVYTLMPMVMADQHRSVSELLSNSKFDVNYAFGRVKRSLLHIAANCGSVECLVLLLKKGAN
PNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICNNEGLTAIKRSKLHEQVLDLGLTWKKIIKFLNEKLEKSKMQSINEDLKDILHA

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>35554_35554_2_HACE1-ASCC3_HACE1_chr6_105291098_ENST00000262903_ASCC3_chr6_101312090_ENST00000369162_length(amino acids)=2306AA_BP=134
MERAMEQLNRLTRSLRRARTVELPEDNETAVYTLMPMVMADQHRSVSELLSNSKFDVNYAFGRVKRSLLHIAANCGSVECLVLLLKKGAN
PNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICNNEGLTAIKRSKLHEQVLDLGLTWKKIIKFLNEKLEKSKMQSINEDLKDILHA
AKQIVGTDNGREAIESGAAFLFMTFHLKDSVGHKETKAIKQMFGPFPSSSATAACNATNRIISHFSQDDLTALVQMTEKEHGDRVFFGKN
LAFSFDMHDLDHFDELPINGETQKTISLDYKKFLNEHLQEACTPELKPVEKTNGSFLWCEVEKYLNSTLKEMTEVPRVEDLCCTLYDMLA
SIKSGDELQDELFELLGPEGLELIEKLLQNRITIVDRFLNSSNDHRFQALQDNCKKILGENAKPNYGCQVTIQSEQEKQLMKQYRREEKR
IARREKKAGEDLEVSEGLMCFDPKELRIQREQALLNARSVPILSRQRDADVEKIHYPHVYDSQAEAMKTSAFIAGAKMILPEGIQRENNK
LYEEVRIPYSEPMPLSFEEKPVYIQDLDEIGQLAFKGMKRLNRIQSIVFETAYNTNENMLICAPTGAGKTNIAMLTVLHEIRQHFQQGVI
KKNEFKIVYVAPMKALAAEMTDYFSRRLEPLGIIVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVALSQIVRLLILDEVHLL
HEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATFLHVNPYIGLFFFDGRFRPVPLGQTFLGIKCANKMQQLNNMDEVCYE
NVLKQVKAGHQVMVFVHARNATVRTAMSLIERAKNCGHIPFFFPTQGHDYVLAEKQVQRSRNKQVRELFPDGFSIHHAGMLRQDRNLVEN
LFSNGHIKVLVCTATLAWGVNLPAHAVIIKGTQIYAAKRGSFVDLGILDVMQIFGRAGRPQFDKFGEGIIITTHDKLSHYLTLLTQRNPI
ESQFLESLADNLNAEIALGTVTNVEEAVKWISYTYLYVRMRANPLAYGISHKAYQIDPTLRKHREQLVIEVGRKLDKAQMIRFEERTGYF
SSTDLGRTASHYYIKYNTIETFNELFDAHKTEGDIFAIVSKAEEFDQIKVREEEIEELDTLLSNFCELSTPGGVENSYGKINILLQTYIS
RGEMDSFSLISDSAYVAQNAARIVRALFEIALRKRWPTMTYRLLNLSKVIDKRLWGWASPLRQFSILPPHILTRLEEKKLTVDKLKDMRK
DEIGHILHHVNIGLKVKQCVHQIPSVMMEASIQPITRTVLRVTLSIYADFTWNDQVHGTVGEPWWIWVEDPTNDHIYHSEYFLALKKQVI
SKEAQLLVFTIPIFEPLPSQYYIRAVSDRWLGAEAVCIINFQHLILPERHPPHTELLDLQPLPITALGCKAYEALYNFSHFNPVQTQIFH
TLYHTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPLKALVRERMDDWKVRIEEKLGKKVIELTGDVTPDMKSIAKADLIVT
TPEKWDGVSRSWQNRNYVQQVTILIIDEIHLLGEERGPVLEVIVSRTNFISSHTEKPVRIVGLSTALANARDLADWLNIKQMGLFNFRPS
VRPVPLEVHIQGFPGQHYCPRMASMNKPAFQAIRSHSPAKPVLIFVSSRRQTRLTALELIAFLATEEDPKQWLNMDEREMENIIATVRDS
NLKLTLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFPAHLVIIKGTEYYDGKTRRYVDFPITDVLQMMGRAGRPQFD
DQGKAVILVHDIKKDFYKKFLYEPFPVESSLLGVLSDHLNAEIAGGTITSKQDALDYITWTYFFRRLIMNPSYYNLGDVSHDSVNKFLSH
LIEKSLIELELSYCIEIGEDNRSIEPLTYGRIASYYYLKHQTVKMFKDRLKPECSTEELLSILSDAEEYTDLPVRHNEDHMNSELAKCLP
IESNPHSFDSPHTKAHLLLQAHLSRAMLPCPDYDTDTKTVLDQALRVCQAMLDVAANQGWLVTVLNITNLIQMVIQGRWLKDSSLLTLPN
IENHHLHLFKKWKPIMKGPHARGRTSIESLPELIHACGGKDHVFSSMVESELHAAKTKQAWNFLSHLPVINVGISVKGSWDDLVEGHNEL
SVSTLTADKRDDNKWIKLHADQEYVLQVSLQRVHFGFHKGKPESCAVTPRFPKSKDEGWFLILGEVDKRELIALKRVGYIRNHHVASLSF

--------------------------------------------------------------

>35554_35554_3_HACE1-ASCC3_HACE1_chr6_105291098_ENST00000262903_ASCC3_chr6_101312090_ENST00000522650_length(amino acids)=835AA_BP=134
MERAMEQLNRLTRSLRRARTVELPEDNETAVYTLMPMVMADQHRSVSELLSNSKFDVNYAFGRVKRSLLHIAANCGSVECLVLLLKKGAN
PNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICNNEGLTAIKRSKLHEQVLDLGLTWKKIIKFLNEKLEKSKMQSINEDLKDILHA
AKQIVGTDNGREAIESGAAFLFMTFHLKDSVGHKETKAIKQMFGPFPSSSATAACNATNRIISHFSQDDLTALVQMTEKEHGDRVFFGKN
LAFSFDMHDLDHFDELPINGETQKTISLDYKKFLNEHLQEACTPELKPVEKTNGSFLWCEVEKYLNSTLKEMTEVPRVEDLCCTLYDMLA
SIKSGDELQDELFELLGPEGLELIEKLLQNRITIVDRFLNSSNDHRFQALQDNCKKILGENAKPNYGCQVTIQSEQEKQLMKQYRREEKR
IARREKKAGEDLEVSEGLMCFDPKELRIQREQALLNARSVPILSRQRDADVEKIHYPHVYDSQAEAMKTSAFIAGAKMILPEGIQRENNK
LYEEVRIPYSEPMPLSFEEKPVYIQDLDEIGQLAFKGMKRLNRIQSIVFETAYNTNENMLICAPTGAGKTNIAMLTVLHEIRQHFQQGVI
KKNEFKIVYVAPMKALAAEMTDYFSRRLEPLGIIVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVALSQIVRLLILDEVHLL
HEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATFLHVNPYIGLFFFDGRFRPVPLGQTFLGIKCANKMQQLNNMDEVCYE

--------------------------------------------------------------

>35554_35554_4_HACE1-ASCC3_HACE1_chr6_105291098_ENST00000369125_ASCC3_chr6_101312090_ENST00000369143_length(amino acids)=215AA_BP=134
MERAMEQLNRLTRSLRRARTVELPEDNETAVYTLMPMVMADQHRSVSELLSNSKFDVNYAFGRVKRSLLHIAANCGSVECLVLLLKKGAN
PNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICNNEGLTAIKRSKLHEQVLDLGLTWKKIIKFLNEKLEKSKMQSINEDLKDILHA

--------------------------------------------------------------

>35554_35554_5_HACE1-ASCC3_HACE1_chr6_105291098_ENST00000369125_ASCC3_chr6_101312090_ENST00000369162_length(amino acids)=2306AA_BP=134
MERAMEQLNRLTRSLRRARTVELPEDNETAVYTLMPMVMADQHRSVSELLSNSKFDVNYAFGRVKRSLLHIAANCGSVECLVLLLKKGAN
PNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICNNEGLTAIKRSKLHEQVLDLGLTWKKIIKFLNEKLEKSKMQSINEDLKDILHA
AKQIVGTDNGREAIESGAAFLFMTFHLKDSVGHKETKAIKQMFGPFPSSSATAACNATNRIISHFSQDDLTALVQMTEKEHGDRVFFGKN
LAFSFDMHDLDHFDELPINGETQKTISLDYKKFLNEHLQEACTPELKPVEKTNGSFLWCEVEKYLNSTLKEMTEVPRVEDLCCTLYDMLA
SIKSGDELQDELFELLGPEGLELIEKLLQNRITIVDRFLNSSNDHRFQALQDNCKKILGENAKPNYGCQVTIQSEQEKQLMKQYRREEKR
IARREKKAGEDLEVSEGLMCFDPKELRIQREQALLNARSVPILSRQRDADVEKIHYPHVYDSQAEAMKTSAFIAGAKMILPEGIQRENNK
LYEEVRIPYSEPMPLSFEEKPVYIQDLDEIGQLAFKGMKRLNRIQSIVFETAYNTNENMLICAPTGAGKTNIAMLTVLHEIRQHFQQGVI
KKNEFKIVYVAPMKALAAEMTDYFSRRLEPLGIIVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVALSQIVRLLILDEVHLL
HEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATFLHVNPYIGLFFFDGRFRPVPLGQTFLGIKCANKMQQLNNMDEVCYE
NVLKQVKAGHQVMVFVHARNATVRTAMSLIERAKNCGHIPFFFPTQGHDYVLAEKQVQRSRNKQVRELFPDGFSIHHAGMLRQDRNLVEN
LFSNGHIKVLVCTATLAWGVNLPAHAVIIKGTQIYAAKRGSFVDLGILDVMQIFGRAGRPQFDKFGEGIIITTHDKLSHYLTLLTQRNPI
ESQFLESLADNLNAEIALGTVTNVEEAVKWISYTYLYVRMRANPLAYGISHKAYQIDPTLRKHREQLVIEVGRKLDKAQMIRFEERTGYF
SSTDLGRTASHYYIKYNTIETFNELFDAHKTEGDIFAIVSKAEEFDQIKVREEEIEELDTLLSNFCELSTPGGVENSYGKINILLQTYIS
RGEMDSFSLISDSAYVAQNAARIVRALFEIALRKRWPTMTYRLLNLSKVIDKRLWGWASPLRQFSILPPHILTRLEEKKLTVDKLKDMRK
DEIGHILHHVNIGLKVKQCVHQIPSVMMEASIQPITRTVLRVTLSIYADFTWNDQVHGTVGEPWWIWVEDPTNDHIYHSEYFLALKKQVI
SKEAQLLVFTIPIFEPLPSQYYIRAVSDRWLGAEAVCIINFQHLILPERHPPHTELLDLQPLPITALGCKAYEALYNFSHFNPVQTQIFH
TLYHTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPLKALVRERMDDWKVRIEEKLGKKVIELTGDVTPDMKSIAKADLIVT
TPEKWDGVSRSWQNRNYVQQVTILIIDEIHLLGEERGPVLEVIVSRTNFISSHTEKPVRIVGLSTALANARDLADWLNIKQMGLFNFRPS
VRPVPLEVHIQGFPGQHYCPRMASMNKPAFQAIRSHSPAKPVLIFVSSRRQTRLTALELIAFLATEEDPKQWLNMDEREMENIIATVRDS
NLKLTLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFPAHLVIIKGTEYYDGKTRRYVDFPITDVLQMMGRAGRPQFD
DQGKAVILVHDIKKDFYKKFLYEPFPVESSLLGVLSDHLNAEIAGGTITSKQDALDYITWTYFFRRLIMNPSYYNLGDVSHDSVNKFLSH
LIEKSLIELELSYCIEIGEDNRSIEPLTYGRIASYYYLKHQTVKMFKDRLKPECSTEELLSILSDAEEYTDLPVRHNEDHMNSELAKCLP
IESNPHSFDSPHTKAHLLLQAHLSRAMLPCPDYDTDTKTVLDQALRVCQAMLDVAANQGWLVTVLNITNLIQMVIQGRWLKDSSLLTLPN
IENHHLHLFKKWKPIMKGPHARGRTSIESLPELIHACGGKDHVFSSMVESELHAAKTKQAWNFLSHLPVINVGISVKGSWDDLVEGHNEL
SVSTLTADKRDDNKWIKLHADQEYVLQVSLQRVHFGFHKGKPESCAVTPRFPKSKDEGWFLILGEVDKRELIALKRVGYIRNHHVASLSF

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>35554_35554_6_HACE1-ASCC3_HACE1_chr6_105291098_ENST00000369125_ASCC3_chr6_101312090_ENST00000522650_length(amino acids)=835AA_BP=134
MERAMEQLNRLTRSLRRARTVELPEDNETAVYTLMPMVMADQHRSVSELLSNSKFDVNYAFGRVKRSLLHIAANCGSVECLVLLLKKGAN
PNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICNNEGLTAIKRSKLHEQVLDLGLTWKKIIKFLNEKLEKSKMQSINEDLKDILHA
AKQIVGTDNGREAIESGAAFLFMTFHLKDSVGHKETKAIKQMFGPFPSSSATAACNATNRIISHFSQDDLTALVQMTEKEHGDRVFFGKN
LAFSFDMHDLDHFDELPINGETQKTISLDYKKFLNEHLQEACTPELKPVEKTNGSFLWCEVEKYLNSTLKEMTEVPRVEDLCCTLYDMLA
SIKSGDELQDELFELLGPEGLELIEKLLQNRITIVDRFLNSSNDHRFQALQDNCKKILGENAKPNYGCQVTIQSEQEKQLMKQYRREEKR
IARREKKAGEDLEVSEGLMCFDPKELRIQREQALLNARSVPILSRQRDADVEKIHYPHVYDSQAEAMKTSAFIAGAKMILPEGIQRENNK
LYEEVRIPYSEPMPLSFEEKPVYIQDLDEIGQLAFKGMKRLNRIQSIVFETAYNTNENMLICAPTGAGKTNIAMLTVLHEIRQHFQQGVI
KKNEFKIVYVAPMKALAAEMTDYFSRRLEPLGIIVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVALSQIVRLLILDEVHLL
HEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATFLHVNPYIGLFFFDGRFRPVPLGQTFLGIKCANKMQQLNNMDEVCYE

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:105291098/chr6:101312090)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HACE1

Q8IYU2

ASCC3

Q8N3C0

FUNCTION: E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB. {ECO:0000269|PubMed:15254018, ECO:0000269|PubMed:21988917, ECO:0000269|PubMed:22036506}.FUNCTION: 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions (PubMed:22055184). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). {ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:22055184}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHACE1chr6:105291098chr6:101312090ENST00000262903-52464_93134.0910.0RepeatNote=ANK 1
HgeneHACE1chr6:105291098chr6:101312090ENST00000262903-52497_126134.0910.0RepeatNote=ANK 2
HgeneHACE1chr6:105291098chr6:101312090ENST00000369125-51964_93134.0695.0RepeatNote=ANK 1
HgeneHACE1chr6:105291098chr6:101312090ENST00000369125-51997_126134.0695.0RepeatNote=ANK 2
TgeneASCC3chr6:105291098chr6:101312090ENST0000036914314328_35630.0112.0Coiled coilOntology_term=ECO:0000255
TgeneASCC3chr6:105291098chr6:101312090ENST00000369162142328_35630.02203.0Coiled coilOntology_term=ECO:0000255
TgeneASCC3chr6:105291098chr6:101312090ENST00000522650113328_35630.0732.0Coiled coilOntology_term=ECO:0000255
TgeneASCC3chr6:105291098chr6:101312090ENST00000369143141336_151130.0112.0DomainHelicase ATP-binding 2
TgeneASCC3chr6:105291098chr6:101312090ENST00000369143141544_173930.0112.0DomainHelicase C-terminal 2
TgeneASCC3chr6:105291098chr6:101312090ENST00000369143141812_217630.0112.0DomainNote=SEC63 2
TgeneASCC3chr6:105291098chr6:101312090ENST0000036914314486_66930.0112.0DomainHelicase ATP-binding 1
TgeneASCC3chr6:105291098chr6:101312090ENST0000036914314728_91430.0112.0DomainHelicase C-terminal 1
TgeneASCC3chr6:105291098chr6:101312090ENST0000036914314978_128730.0112.0DomainNote=SEC63 1
TgeneASCC3chr6:105291098chr6:101312090ENST000003691621421336_151130.02203.0DomainHelicase ATP-binding 2
TgeneASCC3chr6:105291098chr6:101312090ENST000003691621421544_173930.02203.0DomainHelicase C-terminal 2
TgeneASCC3chr6:105291098chr6:101312090ENST000003691621421812_217630.02203.0DomainNote=SEC63 2
TgeneASCC3chr6:105291098chr6:101312090ENST00000369162142486_66930.02203.0DomainHelicase ATP-binding 1
TgeneASCC3chr6:105291098chr6:101312090ENST00000369162142728_91430.02203.0DomainHelicase C-terminal 1
TgeneASCC3chr6:105291098chr6:101312090ENST00000369162142978_128730.02203.0DomainNote=SEC63 1
TgeneASCC3chr6:105291098chr6:101312090ENST000005226501131336_151130.0732.0DomainHelicase ATP-binding 2
TgeneASCC3chr6:105291098chr6:101312090ENST000005226501131544_173930.0732.0DomainHelicase C-terminal 2
TgeneASCC3chr6:105291098chr6:101312090ENST000005226501131812_217630.0732.0DomainNote=SEC63 2
TgeneASCC3chr6:105291098chr6:101312090ENST00000522650113486_66930.0732.0DomainHelicase ATP-binding 1
TgeneASCC3chr6:105291098chr6:101312090ENST00000522650113728_91430.0732.0DomainHelicase C-terminal 1
TgeneASCC3chr6:105291098chr6:101312090ENST00000522650113978_128730.0732.0DomainNote=SEC63 1
TgeneASCC3chr6:105291098chr6:101312090ENST00000369143141453_145630.0112.0MotifNote=DEIH box
TgeneASCC3chr6:105291098chr6:101312090ENST0000036914314611_61430.0112.0MotifNote=DEVH box
TgeneASCC3chr6:105291098chr6:101312090ENST000003691621421453_145630.02203.0MotifNote=DEIH box
TgeneASCC3chr6:105291098chr6:101312090ENST00000369162142611_61430.02203.0MotifNote=DEVH box
TgeneASCC3chr6:105291098chr6:101312090ENST000005226501131453_145630.0732.0MotifNote=DEIH box
TgeneASCC3chr6:105291098chr6:101312090ENST00000522650113611_61430.0732.0MotifNote=DEVH box
TgeneASCC3chr6:105291098chr6:101312090ENST00000369143141349_135630.0112.0Nucleotide bindingATP
TgeneASCC3chr6:105291098chr6:101312090ENST0000036914314499_50630.0112.0Nucleotide bindingATP
TgeneASCC3chr6:105291098chr6:101312090ENST000003691621421349_135630.02203.0Nucleotide bindingATP
TgeneASCC3chr6:105291098chr6:101312090ENST00000369162142499_50630.02203.0Nucleotide bindingATP
TgeneASCC3chr6:105291098chr6:101312090ENST000005226501131349_135630.0732.0Nucleotide bindingATP
TgeneASCC3chr6:105291098chr6:101312090ENST00000522650113499_50630.0732.0Nucleotide bindingATP

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHACE1chr6:105291098chr6:101312090ENST00000262903-524574_909134.0910.0DomainHECT
HgeneHACE1chr6:105291098chr6:101312090ENST00000369125-519574_909134.0695.0DomainHECT
HgeneHACE1chr6:105291098chr6:101312090ENST00000262903-524130_159134.0910.0RepeatNote=ANK 3
HgeneHACE1chr6:105291098chr6:101312090ENST00000262903-524163_192134.0910.0RepeatNote=ANK 4
HgeneHACE1chr6:105291098chr6:101312090ENST00000262903-524196_226134.0910.0RepeatNote=ANK 5
HgeneHACE1chr6:105291098chr6:101312090ENST00000262903-524228_257134.0910.0RepeatNote=ANK 6
HgeneHACE1chr6:105291098chr6:101312090ENST00000369125-519130_159134.0695.0RepeatNote=ANK 3
HgeneHACE1chr6:105291098chr6:101312090ENST00000369125-519163_192134.0695.0RepeatNote=ANK 4
HgeneHACE1chr6:105291098chr6:101312090ENST00000369125-519196_226134.0695.0RepeatNote=ANK 5
HgeneHACE1chr6:105291098chr6:101312090ENST00000369125-519228_257134.0695.0RepeatNote=ANK 6
TgeneASCC3chr6:105291098chr6:101312090ENST000003691431418_7930.0112.0Coiled coilOntology_term=ECO:0000255
TgeneASCC3chr6:105291098chr6:101312090ENST0000036916214218_7930.02203.0Coiled coilOntology_term=ECO:0000255
TgeneASCC3chr6:105291098chr6:101312090ENST0000052265011318_7930.0732.0Coiled coilOntology_term=ECO:0000255


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
HACE1
ASCC3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to HACE1-ASCC3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to HACE1-ASCC3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource