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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:HACL1-RAF1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: HACL1-RAF1
FusionPDB ID: 35563
FusionGDB2.0 ID: 35563
HgeneTgene
Gene symbol

HACL1

RAF1

Gene ID

337880

6037

Gene namekeratin associated protein 11-1ribonuclease A family member 3
SynonymsHACL-1|HACL1|KAP11.1ECP|RAF1|RNS3
Cytomap

21q22.11

14q11.2

Type of geneprotein-codingprotein-coding
Descriptionkeratin-associated protein 11-1high sulfur keratin-associated protein 11.1eosinophil cationic proteinRNase 3cytotoxic ribonucleaseribonuclease 3ribonuclease, RNase A family, 3
Modification date2020031320200313
UniProtAcc

Q9UJ83

P04049

Ensembl transtripts involved in fusion geneENST idsENST00000321169, ENST00000435217, 
ENST00000451445, ENST00000456194, 
ENST00000457447, 		ENST00000251849, 
ENST00000442415, ENST00000534997, 
ENST00000542177, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 6 X 4=16819 X 16 X 7=2128
# samples 718
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/2128*10)=-3.56342933917152
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: HACL1 [Title/Abstract] AND RAF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRAF1

GO:0002227

innate immune response in mucosa

12860195

TgeneRAF1

GO:0019731

antibacterial humoral response

12860195

TgeneRAF1

GO:0043152

induction of bacterial agglutination

23992292

TgeneRAF1

GO:0045087

innate immune response

23992292

TgeneRAF1

GO:0050829

defense response to Gram-negative bacterium

23992292

TgeneRAF1

GO:0050830

defense response to Gram-positive bacterium

12860195|23992292

TgeneRAF1

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

12860195


check buttonFusion gene breakpoints across HACL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RAF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..HACL1chr3

15604864

-RAF1chr3

12641914

-
ChimerKB3..HACL1chr3

15604864

-RAF1chr3

46425057

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000321169HACL1chr315604864-ENST00000251849RAF1chr312641914-409820723683184938
ENST00000321169HACL1chr315604864-ENST00000442415RAF1chr312641914-390120723683184938
ENST00000321169HACL1chr315604864-ENST00000534997RAF1chr312641914-343220723683184938
ENST00000321169HACL1chr315604864-ENST00000542177RAF1chr312641914-336620723683184938
ENST00000435217HACL1chr315604864-ENST00000251849RAF1chr312641914-311310871062199697
ENST00000435217HACL1chr315604864-ENST00000442415RAF1chr312641914-291610871062199697
ENST00000435217HACL1chr315604864-ENST00000534997RAF1chr312641914-244710871062199697
ENST00000435217HACL1chr315604864-ENST00000542177RAF1chr312641914-238110871062199697
ENST00000451445HACL1chr315604864-ENST00000251849RAF1chr312641914-360815821242694856
ENST00000451445HACL1chr315604864-ENST00000442415RAF1chr312641914-341115821242694856
ENST00000451445HACL1chr315604864-ENST00000534997RAF1chr312641914-294215821242694856
ENST00000451445HACL1chr315604864-ENST00000542177RAF1chr312641914-287615821242694856
ENST00000456194HACL1chr315604864-ENST00000251849RAF1chr312641914-375517291062841911
ENST00000456194HACL1chr315604864-ENST00000442415RAF1chr312641914-355817291062841911
ENST00000456194HACL1chr315604864-ENST00000534997RAF1chr312641914-308917291062841911
ENST00000456194HACL1chr315604864-ENST00000542177RAF1chr312641914-302317291062841911
ENST00000457447HACL1chr315604864-ENST00000251849RAF1chr312641914-365616301062742878
ENST00000457447HACL1chr315604864-ENST00000442415RAF1chr312641914-345916301062742878
ENST00000457447HACL1chr315604864-ENST00000534997RAF1chr312641914-299016301062742878
ENST00000457447HACL1chr315604864-ENST00000542177RAF1chr312641914-292416301062742878

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>35563_35563_1_HACL1-RAF1_HACL1_chr3_15604864_ENST00000321169_RAF1_chr3_12641914_ENST00000251849_length(amino acids)=938AA_BP=567
MPDSNFAERSEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIH
ALGGMANANMNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVDIPADFVNLQVN
VNSIKYMERCMSPPISMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPMGKGVVPDNHPYCVGAARSRAL
QFADVIVLFGARLNWILHFGLPPRYQPDVKFIQVDICAEELGNNVKPAVTLLGNIHAVTKQLLEELDKTPWQYPPESKWWKTLREKMKSN
EAASKELASKKSLPMNYYTVFYHVQEQLPRDCFVVSEGANTMDIGRTVLQNYLPRHRLDAGTFGTMGVGLGFAIAAAVVAKDRSPGQWII
CVEGDSAFGFSGMEVETICRYNLPIILLVVNNNGIYQGFDTDTWKEMLKFQDATAVVPPMCLLPNSHYEQVMTAFGGKGYFVQTPEELQK
SLRQSLADTTKPSLINIMIEPQATRKAQDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSY
YWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLY
KHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQ
DNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQ

--------------------------------------------------------------

>35563_35563_2_HACL1-RAF1_HACL1_chr3_15604864_ENST00000321169_RAF1_chr3_12641914_ENST00000442415_length(amino acids)=938AA_BP=567
MPDSNFAERSEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIH
ALGGMANANMNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVDIPADFVNLQVN
VNSIKYMERCMSPPISMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPMGKGVVPDNHPYCVGAARSRAL
QFADVIVLFGARLNWILHFGLPPRYQPDVKFIQVDICAEELGNNVKPAVTLLGNIHAVTKQLLEELDKTPWQYPPESKWWKTLREKMKSN
EAASKELASKKSLPMNYYTVFYHVQEQLPRDCFVVSEGANTMDIGRTVLQNYLPRHRLDAGTFGTMGVGLGFAIAAAVVAKDRSPGQWII
CVEGDSAFGFSGMEVETICRYNLPIILLVVNNNGIYQGFDTDTWKEMLKFQDATAVVPPMCLLPNSHYEQVMTAFGGKGYFVQTPEELQK
SLRQSLADTTKPSLINIMIEPQATRKAQDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSY
YWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLY
KHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQ
DNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQ

--------------------------------------------------------------

>35563_35563_3_HACL1-RAF1_HACL1_chr3_15604864_ENST00000321169_RAF1_chr3_12641914_ENST00000534997_length(amino acids)=938AA_BP=567
MPDSNFAERSEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIH
ALGGMANANMNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVDIPADFVNLQVN
VNSIKYMERCMSPPISMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPMGKGVVPDNHPYCVGAARSRAL
QFADVIVLFGARLNWILHFGLPPRYQPDVKFIQVDICAEELGNNVKPAVTLLGNIHAVTKQLLEELDKTPWQYPPESKWWKTLREKMKSN
EAASKELASKKSLPMNYYTVFYHVQEQLPRDCFVVSEGANTMDIGRTVLQNYLPRHRLDAGTFGTMGVGLGFAIAAAVVAKDRSPGQWII
CVEGDSAFGFSGMEVETICRYNLPIILLVVNNNGIYQGFDTDTWKEMLKFQDATAVVPPMCLLPNSHYEQVMTAFGGKGYFVQTPEELQK
SLRQSLADTTKPSLINIMIEPQATRKAQDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSY
YWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLY
KHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQ
DNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQ

--------------------------------------------------------------

>35563_35563_4_HACL1-RAF1_HACL1_chr3_15604864_ENST00000321169_RAF1_chr3_12641914_ENST00000542177_length(amino acids)=938AA_BP=567
MPDSNFAERSEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIH
ALGGMANANMNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVDIPADFVNLQVN
VNSIKYMERCMSPPISMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPMGKGVVPDNHPYCVGAARSRAL
QFADVIVLFGARLNWILHFGLPPRYQPDVKFIQVDICAEELGNNVKPAVTLLGNIHAVTKQLLEELDKTPWQYPPESKWWKTLREKMKSN
EAASKELASKKSLPMNYYTVFYHVQEQLPRDCFVVSEGANTMDIGRTVLQNYLPRHRLDAGTFGTMGVGLGFAIAAAVVAKDRSPGQWII
CVEGDSAFGFSGMEVETICRYNLPIILLVVNNNGIYQGFDTDTWKEMLKFQDATAVVPPMCLLPNSHYEQVMTAFGGKGYFVQTPEELQK
SLRQSLADTTKPSLINIMIEPQATRKAQDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSY
YWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLY
KHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQ
DNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQ

--------------------------------------------------------------

>35563_35563_5_HACL1-RAF1_HACL1_chr3_15604864_ENST00000435217_RAF1_chr3_12641914_ENST00000251849_length(amino acids)=697AA_BP=326
MPDSNFAERSEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAVDICAEELGNNVKPAVTLLGNIHAVTKQ
LLEELDKTPWQYPPESKWWKTLREKMKSNEAASKELASKKSLPMNYYTVFYHVQEQLPRDCFVVSEGANTMDIGRTVLQNYLPRHRLDAG
TFGTMGVGLGFAIAAAVVAKDRSPGQWIICVEGDSAFGFSGMEVETICRYNLPIILLVVNNNGIYQGFDTDTWKEMLKFQDATAVVPPMC
LLPNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSLADTTKPSLINIMIEPQATRKAQDAIRSHSESASPSALSSSPNNLSPTGWSQPKTP
VPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTR
HVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLAT
VKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAM

--------------------------------------------------------------

>35563_35563_6_HACL1-RAF1_HACL1_chr3_15604864_ENST00000435217_RAF1_chr3_12641914_ENST00000442415_length(amino acids)=697AA_BP=326
MPDSNFAERSEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAVDICAEELGNNVKPAVTLLGNIHAVTKQ
LLEELDKTPWQYPPESKWWKTLREKMKSNEAASKELASKKSLPMNYYTVFYHVQEQLPRDCFVVSEGANTMDIGRTVLQNYLPRHRLDAG
TFGTMGVGLGFAIAAAVVAKDRSPGQWIICVEGDSAFGFSGMEVETICRYNLPIILLVVNNNGIYQGFDTDTWKEMLKFQDATAVVPPMC
LLPNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSLADTTKPSLINIMIEPQATRKAQDAIRSHSESASPSALSSSPNNLSPTGWSQPKTP
VPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTR
HVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLAT
VKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAM

--------------------------------------------------------------

>35563_35563_7_HACL1-RAF1_HACL1_chr3_15604864_ENST00000435217_RAF1_chr3_12641914_ENST00000534997_length(amino acids)=697AA_BP=326
MPDSNFAERSEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAVDICAEELGNNVKPAVTLLGNIHAVTKQ
LLEELDKTPWQYPPESKWWKTLREKMKSNEAASKELASKKSLPMNYYTVFYHVQEQLPRDCFVVSEGANTMDIGRTVLQNYLPRHRLDAG
TFGTMGVGLGFAIAAAVVAKDRSPGQWIICVEGDSAFGFSGMEVETICRYNLPIILLVVNNNGIYQGFDTDTWKEMLKFQDATAVVPPMC
LLPNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSLADTTKPSLINIMIEPQATRKAQDAIRSHSESASPSALSSSPNNLSPTGWSQPKTP
VPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTR
HVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLAT
VKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAM

--------------------------------------------------------------

>35563_35563_8_HACL1-RAF1_HACL1_chr3_15604864_ENST00000435217_RAF1_chr3_12641914_ENST00000542177_length(amino acids)=697AA_BP=326
MPDSNFAERSEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAVDICAEELGNNVKPAVTLLGNIHAVTKQ
LLEELDKTPWQYPPESKWWKTLREKMKSNEAASKELASKKSLPMNYYTVFYHVQEQLPRDCFVVSEGANTMDIGRTVLQNYLPRHRLDAG
TFGTMGVGLGFAIAAAVVAKDRSPGQWIICVEGDSAFGFSGMEVETICRYNLPIILLVVNNNGIYQGFDTDTWKEMLKFQDATAVVPPMC
LLPNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSLADTTKPSLINIMIEPQATRKAQDAIRSHSESASPSALSSSPNNLSPTGWSQPKTP
VPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTR
HVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLAT
VKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAM

--------------------------------------------------------------

>35563_35563_9_HACL1-RAF1_HACL1_chr3_15604864_ENST00000451445_RAF1_chr3_12641914_ENST00000251849_length(amino acids)=856AA_BP=485
MPDSNFAERSEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIH
ALGGMANANMNCWYMERCMSPPISMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPMGKGVVPDNHPYCV
GAARSRALQFADVIVLFGARLNWILHFGLPPRYQPDVKFIQVDICAEELGNNVKPAVTLLGNIHAVTKQLLEELDKTPWQYPPESKWWKT
LREKMKSNEAASKELASKKSLPMNYYTVFYHVQEQLPRDCFVVSEGANTMDIGRTVLQNYLPRHRLDAGTFGTMGVGLGFAIAAAVVAKD
RSPGQWIICVEGDSAFGFSGMEVETICRYNLPIILLVVNNNGIYQGFDTDTWKEMLKFQDATAVVPPMCLLPNSHYEQVMTAFGGKGYFV
QTPEELQKSLRQSLADTTKPSLINIMIEPQATRKAQDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRP
RGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQ
WCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWM
APEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQI

--------------------------------------------------------------

>35563_35563_10_HACL1-RAF1_HACL1_chr3_15604864_ENST00000451445_RAF1_chr3_12641914_ENST00000442415_length(amino acids)=856AA_BP=485
MPDSNFAERSEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIH
ALGGMANANMNCWYMERCMSPPISMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPMGKGVVPDNHPYCV
GAARSRALQFADVIVLFGARLNWILHFGLPPRYQPDVKFIQVDICAEELGNNVKPAVTLLGNIHAVTKQLLEELDKTPWQYPPESKWWKT
LREKMKSNEAASKELASKKSLPMNYYTVFYHVQEQLPRDCFVVSEGANTMDIGRTVLQNYLPRHRLDAGTFGTMGVGLGFAIAAAVVAKD
RSPGQWIICVEGDSAFGFSGMEVETICRYNLPIILLVVNNNGIYQGFDTDTWKEMLKFQDATAVVPPMCLLPNSHYEQVMTAFGGKGYFV
QTPEELQKSLRQSLADTTKPSLINIMIEPQATRKAQDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRP
RGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQ
WCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWM
APEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQI

--------------------------------------------------------------

>35563_35563_11_HACL1-RAF1_HACL1_chr3_15604864_ENST00000451445_RAF1_chr3_12641914_ENST00000534997_length(amino acids)=856AA_BP=485
MPDSNFAERSEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIH
ALGGMANANMNCWYMERCMSPPISMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPMGKGVVPDNHPYCV
GAARSRALQFADVIVLFGARLNWILHFGLPPRYQPDVKFIQVDICAEELGNNVKPAVTLLGNIHAVTKQLLEELDKTPWQYPPESKWWKT
LREKMKSNEAASKELASKKSLPMNYYTVFYHVQEQLPRDCFVVSEGANTMDIGRTVLQNYLPRHRLDAGTFGTMGVGLGFAIAAAVVAKD
RSPGQWIICVEGDSAFGFSGMEVETICRYNLPIILLVVNNNGIYQGFDTDTWKEMLKFQDATAVVPPMCLLPNSHYEQVMTAFGGKGYFV
QTPEELQKSLRQSLADTTKPSLINIMIEPQATRKAQDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRP
RGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQ
WCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWM
APEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQI

--------------------------------------------------------------

>35563_35563_12_HACL1-RAF1_HACL1_chr3_15604864_ENST00000451445_RAF1_chr3_12641914_ENST00000542177_length(amino acids)=856AA_BP=485
MPDSNFAERSEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIH
ALGGMANANMNCWYMERCMSPPISMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPMGKGVVPDNHPYCV
GAARSRALQFADVIVLFGARLNWILHFGLPPRYQPDVKFIQVDICAEELGNNVKPAVTLLGNIHAVTKQLLEELDKTPWQYPPESKWWKT
LREKMKSNEAASKELASKKSLPMNYYTVFYHVQEQLPRDCFVVSEGANTMDIGRTVLQNYLPRHRLDAGTFGTMGVGLGFAIAAAVVAKD
RSPGQWIICVEGDSAFGFSGMEVETICRYNLPIILLVVNNNGIYQGFDTDTWKEMLKFQDATAVVPPMCLLPNSHYEQVMTAFGGKGYFV
QTPEELQKSLRQSLADTTKPSLINIMIEPQATRKAQDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRP
RGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQ
WCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWM
APEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQI

--------------------------------------------------------------

>35563_35563_13_HACL1-RAF1_HACL1_chr3_15604864_ENST00000456194_RAF1_chr3_12641914_ENST00000251849_length(amino acids)=911AA_BP=540
MPDSNFAERSEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPLLVIGGSSERNQE
TMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVDIPADFVNLQVNVNSIKYMERCMSPPISMAETSAVCTAA
SVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPMGKGVVPDNHPYCVGAARSRALQFADVIVLFGARLNWILHFGLPPRYQP
DVKFIQVDICAEELGNNVKPAVTLLGNIHAVTKQLLEELDKTPWQYPPESKWWKTLREKMKSNEAASKELASKKSLPMNYYTVFYHVQEQ
LPRDCFVVSEGANTMDIGRTVLQNYLPRHRLDAGTFGTMGVGLGFAIAAAVVAKDRSPGQWIICVEGDSAFGFSGMEVETICRYNLPIIL
LVVNNNGIYQGFDTDTWKEMLKFQDATAVVPPMCLLPNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSLADTTKPSLINIMIEPQATRKA
QDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGK
WHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMD
YLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELP
YSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINAC

--------------------------------------------------------------

>35563_35563_14_HACL1-RAF1_HACL1_chr3_15604864_ENST00000456194_RAF1_chr3_12641914_ENST00000442415_length(amino acids)=911AA_BP=540
MPDSNFAERSEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPLLVIGGSSERNQE
TMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVDIPADFVNLQVNVNSIKYMERCMSPPISMAETSAVCTAA
SVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPMGKGVVPDNHPYCVGAARSRALQFADVIVLFGARLNWILHFGLPPRYQP
DVKFIQVDICAEELGNNVKPAVTLLGNIHAVTKQLLEELDKTPWQYPPESKWWKTLREKMKSNEAASKELASKKSLPMNYYTVFYHVQEQ
LPRDCFVVSEGANTMDIGRTVLQNYLPRHRLDAGTFGTMGVGLGFAIAAAVVAKDRSPGQWIICVEGDSAFGFSGMEVETICRYNLPIIL
LVVNNNGIYQGFDTDTWKEMLKFQDATAVVPPMCLLPNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSLADTTKPSLINIMIEPQATRKA
QDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGK
WHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMD
YLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELP
YSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINAC

--------------------------------------------------------------

>35563_35563_15_HACL1-RAF1_HACL1_chr3_15604864_ENST00000456194_RAF1_chr3_12641914_ENST00000534997_length(amino acids)=911AA_BP=540
MPDSNFAERSEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPLLVIGGSSERNQE
TMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVDIPADFVNLQVNVNSIKYMERCMSPPISMAETSAVCTAA
SVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPMGKGVVPDNHPYCVGAARSRALQFADVIVLFGARLNWILHFGLPPRYQP
DVKFIQVDICAEELGNNVKPAVTLLGNIHAVTKQLLEELDKTPWQYPPESKWWKTLREKMKSNEAASKELASKKSLPMNYYTVFYHVQEQ
LPRDCFVVSEGANTMDIGRTVLQNYLPRHRLDAGTFGTMGVGLGFAIAAAVVAKDRSPGQWIICVEGDSAFGFSGMEVETICRYNLPIIL
LVVNNNGIYQGFDTDTWKEMLKFQDATAVVPPMCLLPNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSLADTTKPSLINIMIEPQATRKA
QDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGK
WHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMD
YLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELP
YSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINAC

--------------------------------------------------------------

>35563_35563_16_HACL1-RAF1_HACL1_chr3_15604864_ENST00000456194_RAF1_chr3_12641914_ENST00000542177_length(amino acids)=911AA_BP=540
MPDSNFAERSEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPLLVIGGSSERNQE
TMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVDIPADFVNLQVNVNSIKYMERCMSPPISMAETSAVCTAA
SVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPMGKGVVPDNHPYCVGAARSRALQFADVIVLFGARLNWILHFGLPPRYQP
DVKFIQVDICAEELGNNVKPAVTLLGNIHAVTKQLLEELDKTPWQYPPESKWWKTLREKMKSNEAASKELASKKSLPMNYYTVFYHVQEQ
LPRDCFVVSEGANTMDIGRTVLQNYLPRHRLDAGTFGTMGVGLGFAIAAAVVAKDRSPGQWIICVEGDSAFGFSGMEVETICRYNLPIIL
LVVNNNGIYQGFDTDTWKEMLKFQDATAVVPPMCLLPNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSLADTTKPSLINIMIEPQATRKA
QDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGK
WHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMD
YLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELP
YSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINAC

--------------------------------------------------------------

>35563_35563_17_HACL1-RAF1_HACL1_chr3_15604864_ENST00000457447_RAF1_chr3_12641914_ENST00000251849_length(amino acids)=878AA_BP=507
MPDSNFAERSEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIH
ALGGMANANMNCWPLLVIGGSSERNQETMGAFQEFPQAVRSSIYGRPGACYVDIPADFVNLQVNVNSIKYMERCMSPPISMAETSAVCTA
ASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPMGKGVVPDNHPYCVGAARSRALQFADVIVLFGARLNWILHFGLPPRYQ
PDVKFIQVDICAEELGNNVKPAVTLLGNIHAVTKQELASKKSLPMNYYTVFYHVQEQLPRDCFVVSEGANTMDIGRTVLQNYLPRHRLDA
GTFGTMGVGLGFAIAAAVVAKDRSPGQWIICVEGDSAFGFSGMEVETICRYNLPIILLVVNNNGIYQGFDTDTWKEMLKFQDATAVVPPM
CLLPNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSLADTTKPSLINIMIEPQATRKAQDAIRSHSESASPSALSSSPNNLSPTGWSQPKT
PVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKT
RHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLA
TVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKA

--------------------------------------------------------------

>35563_35563_18_HACL1-RAF1_HACL1_chr3_15604864_ENST00000457447_RAF1_chr3_12641914_ENST00000442415_length(amino acids)=878AA_BP=507
MPDSNFAERSEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIH
ALGGMANANMNCWPLLVIGGSSERNQETMGAFQEFPQAVRSSIYGRPGACYVDIPADFVNLQVNVNSIKYMERCMSPPISMAETSAVCTA
ASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPMGKGVVPDNHPYCVGAARSRALQFADVIVLFGARLNWILHFGLPPRYQ
PDVKFIQVDICAEELGNNVKPAVTLLGNIHAVTKQELASKKSLPMNYYTVFYHVQEQLPRDCFVVSEGANTMDIGRTVLQNYLPRHRLDA
GTFGTMGVGLGFAIAAAVVAKDRSPGQWIICVEGDSAFGFSGMEVETICRYNLPIILLVVNNNGIYQGFDTDTWKEMLKFQDATAVVPPM
CLLPNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSLADTTKPSLINIMIEPQATRKAQDAIRSHSESASPSALSSSPNNLSPTGWSQPKT
PVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKT
RHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLA
TVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKA

--------------------------------------------------------------

>35563_35563_19_HACL1-RAF1_HACL1_chr3_15604864_ENST00000457447_RAF1_chr3_12641914_ENST00000534997_length(amino acids)=878AA_BP=507
MPDSNFAERSEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIH
ALGGMANANMNCWPLLVIGGSSERNQETMGAFQEFPQAVRSSIYGRPGACYVDIPADFVNLQVNVNSIKYMERCMSPPISMAETSAVCTA
ASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPMGKGVVPDNHPYCVGAARSRALQFADVIVLFGARLNWILHFGLPPRYQ
PDVKFIQVDICAEELGNNVKPAVTLLGNIHAVTKQELASKKSLPMNYYTVFYHVQEQLPRDCFVVSEGANTMDIGRTVLQNYLPRHRLDA
GTFGTMGVGLGFAIAAAVVAKDRSPGQWIICVEGDSAFGFSGMEVETICRYNLPIILLVVNNNGIYQGFDTDTWKEMLKFQDATAVVPPM
CLLPNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSLADTTKPSLINIMIEPQATRKAQDAIRSHSESASPSALSSSPNNLSPTGWSQPKT
PVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKT
RHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLA
TVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKA

--------------------------------------------------------------

>35563_35563_20_HACL1-RAF1_HACL1_chr3_15604864_ENST00000457447_RAF1_chr3_12641914_ENST00000542177_length(amino acids)=878AA_BP=507
MPDSNFAERSEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIH
ALGGMANANMNCWPLLVIGGSSERNQETMGAFQEFPQAVRSSIYGRPGACYVDIPADFVNLQVNVNSIKYMERCMSPPISMAETSAVCTA
ASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPMGKGVVPDNHPYCVGAARSRALQFADVIVLFGARLNWILHFGLPPRYQ
PDVKFIQVDICAEELGNNVKPAVTLLGNIHAVTKQELASKKSLPMNYYTVFYHVQEQLPRDCFVVSEGANTMDIGRTVLQNYLPRHRLDA
GTFGTMGVGLGFAIAAAVVAKDRSPGQWIICVEGDSAFGFSGMEVETICRYNLPIILLVVNNNGIYQGFDTDTWKEMLKFQDATAVVPPM
CLLPNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSLADTTKPSLINIMIEPQATRKAQDAIRSHSESASPSALSSSPNNLSPTGWSQPKT
PVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKT
RHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLA
TVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKA

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:/chr3:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HACL1

Q9UJ83

RAF1

P04049

FUNCTION: Peroxisomal 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner (PubMed:28289220, PubMed:21708296, PubMed:10468558). Involved in the degradation of 3-methyl-branched fatty acids like phytanic acid and the shortening of 2-hydroxy long-chain fatty acids (PubMed:28289220, PubMed:21708296, PubMed:10468558). Plays a significant role in the biosynthesis of heptadecanal in the liver (By similarity). {ECO:0000250|UniProtKB:Q9QXE0, ECO:0000269|PubMed:10468558, ECO:0000269|PubMed:21708296, ECO:0000269|PubMed:28289220}.FUNCTION: Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (564) >>>564.pdbFusion protein BP residue: 326
CIF file (564) >>>564.cif		HACL1chr315604864-RAF1chr312641914-
MPDSNFAERSEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQL
GIKYIGMRNEQAVDICAEELGNNVKPAVTLLGNIHAVTKQLLEELDKTPW
QYPPESKWWKTLREKMKSNEAASKELASKKSLPMNYYTVFYHVQEQLPRD
CFVVSEGANTMDIGRTVLQNYLPRHRLDAGTFGTMGVGLGFAIAAAVVAK
DRSPGQWIICVEGDSAFGFSGMEVETICRYNLPIILLVVNNNGIYQGFDT
DTWKEMLKFQDATAVVPPMCLLPNSHYEQVMTAFGGKGYFVQTPEELQKS
LRQSLADTTKPSLINIMIEPQATRKAQDAIRSHSESASPSALSSSPNNLS
PTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVML
STRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTR
HVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQ
TAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQ
VEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHI
NNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQ
697
3D view using mol* of 564 (AA BP:326)
PDB file (681) >>>681.pdbFusion protein BP residue: 485
CIF file (681) >>>681.cif		HACL1chr315604864-RAF1chr312641914-
MPDSNFAERSEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQL
GIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIHALGGMANANM
NCWYMERCMSPPISMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEES
IKKLVEQYKLPFLPTPMGKGVVPDNHPYCVGAARSRALQFADVIVLFGAR
LNWILHFGLPPRYQPDVKFIQVDICAEELGNNVKPAVTLLGNIHAVTKQL
LEELDKTPWQYPPESKWWKTLREKMKSNEAASKELASKKSLPMNYYTVFY
HVQEQLPRDCFVVSEGANTMDIGRTVLQNYLPRHRLDAGTFGTMGVGLGF
AIAAAVVAKDRSPGQWIICVEGDSAFGFSGMEVETICRYNLPIILLVVNN
NGIYQGFDTDTWKEMLKFQDATAVVPPMCLLPNSHYEQVMTAFGGKGYFV
QTPEELQKSLRQSLADTTKPSLINIMIEPQATRKAQDAIRSHSESASPSA
LSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYW
EIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRN
EVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQM
FQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATV
KSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELM
TGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKV
KEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTS
856
3D view using mol* of 681 (AA BP:485)
PDB file (694) >>>694.pdbFusion protein BP residue: 507
CIF file (694) >>>694.cif		HACL1chr315604864-RAF1chr312641914-
MPDSNFAERSEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQL
GIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIHALGGMANANM
NCWPLLVIGGSSERNQETMGAFQEFPQAVRSSIYGRPGACYVDIPADFVN
LQVNVNSIKYMERCMSPPISMAETSAVCTAASVIRNAKQPLLIIGKGAAY
AHAEESIKKLVEQYKLPFLPTPMGKGVVPDNHPYCVGAARSRALQFADVI
VLFGARLNWILHFGLPPRYQPDVKFIQVDICAEELGNNVKPAVTLLGNIH
AVTKQELASKKSLPMNYYTVFYHVQEQLPRDCFVVSEGANTMDIGRTVLQ
NYLPRHRLDAGTFGTMGVGLGFAIAAAVVAKDRSPGQWIICVEGDSAFGF
SGMEVETICRYNLPIILLVVNNNGIYQGFDTDTWKEMLKFQDATAVVPPM
CLLPNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSLADTTKPSLINIMIE
PQATRKAQDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAP
VSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHG
DVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMK
SNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQ
DNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDL
SKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSA
878
3D view using mol* of 694 (AA BP:507)
PDB file (707) >>>707.pdbFusion protein BP residue: 540
CIF file (707) >>>707.cif		HACL1chr315604864-RAF1chr312641914-
MPDSNFAERSEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQL
GIKYIGMRNEQAACYAASAIGYLTSRPLLVIGGSSERNQETMGAFQEFPQ
VEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVDIPADFVNL
QVNVNSIKYMERCMSPPISMAETSAVCTAASVIRNAKQPLLIIGKGAAYA
HAEESIKKLVEQYKLPFLPTPMGKGVVPDNHPYCVGAARSRALQFADVIV
LFGARLNWILHFGLPPRYQPDVKFIQVDICAEELGNNVKPAVTLLGNIHA
VTKQLLEELDKTPWQYPPESKWWKTLREKMKSNEAASKELASKKSLPMNY
YTVFYHVQEQLPRDCFVVSEGANTMDIGRTVLQNYLPRHRLDAGTFGTMG
VGLGFAIAAAVVAKDRSPGQWIICVEGDSAFGFSGMEVETICRYNLPIIL
LVVNNNGIYQGFDTDTWKEMLKFQDATAVVPPMCLLPNSHYEQVMTAFGG
KGYFVQTPEELQKSLRQSLADTTKPSLINIMIEPQATRKAQDAIRSHSES
ASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRD
SSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQF
QAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQE
TKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDF
GLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIV
LYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVAD
CVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINAC
911
3D view using mol* of 707 (AA BP:540)
PDB file (720) >>>720.pdbFusion protein BP residue: 567
CIF file (720) >>>720.cif		HACL1chr315604864-RAF1chr312641914-
MPDSNFAERSEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQL
GIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIHALGGMANANM
NCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFV
IEKAVRSSIYGRPGACYVDIPADFVNLQVNVNSIKYMERCMSPPISMAET
SAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPMG
KGVVPDNHPYCVGAARSRALQFADVIVLFGARLNWILHFGLPPRYQPDVK
FIQVDICAEELGNNVKPAVTLLGNIHAVTKQLLEELDKTPWQYPPESKWW
KTLREKMKSNEAASKELASKKSLPMNYYTVFYHVQEQLPRDCFVVSEGAN
TMDIGRTVLQNYLPRHRLDAGTFGTMGVGLGFAIAAAVVAKDRSPGQWII
CVEGDSAFGFSGMEVETICRYNLPIILLVVNNNGIYQGFDTDTWKEMLKF
QDATAVVPPMCLLPNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSLADTT
KPSLINIMIEPQATRKAQDAIRSHSESASPSALSSSPNNLSPTGWSQPKT
PVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMG
YMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLH
AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVL
WMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFM
VGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQ
938
3D view using mol* of 720 (AA BP:567)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
HACL1_pLDDT.png
all structure
all structure
RAF1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
HACL1_RAF1_564_pLDDT.png (AA BP:326)
all structure
HACL1_RAF1_564_pLDDT_and_active_sites.png (AA BP:326)
all structure
HACL1_RAF1_564_violinplot.png (AA BP:326)
all structure
HACL1_RAF1_681_pLDDT.png (AA BP:485)
all structure
HACL1_RAF1_681_pLDDT_and_active_sites.png (AA BP:485)
all structure
HACL1_RAF1_681_violinplot.png (AA BP:485)
all structure
HACL1_RAF1_694_pLDDT.png (AA BP:507)
all structure
HACL1_RAF1_694_pLDDT_and_active_sites.png (AA BP:507)
all structure
HACL1_RAF1_694_violinplot.png (AA BP:507)
all structure
HACL1_RAF1_707_pLDDT.png (AA BP:540)
all structure
HACL1_RAF1_707_pLDDT_and_active_sites.png (AA BP:540)
all structure
HACL1_RAF1_707_violinplot.png (AA BP:540)
all structure
HACL1_RAF1_720_pLDDT.png (AA BP:567)
all structure
HACL1_RAF1_720_pLDDT_and_active_sites.png (AA BP:567)
all structure
HACL1_RAF1_720_violinplot.png (AA BP:567)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
HACL1_RAF1_564.png
all structure
HACL1_RAF1_681.png
all structure
HACL1_RAF1_694.png
all structure
HACL1_RAF1_707.png
all structure
HACL1_RAF1_720.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
5641.0531461.064407.4840.510.7770.9831.0011.050.9531.001Chain A: 404,405,406,407,408,409,410,412,422,424,4
42,446,455,457,468,470,471,472,473,474,475,476,477
,479,517,519,521,522,524,534,535,536,538,542,555,5
56
6811.0763101.108666.4490.4280.7750.9950.8570.9120.9390.702Chain A: 137,163,164,165,166,169,174,175,176,177,1
79,181,182,183,184,185,203,204,205,206,212,274,275
,278,279,282,283,296,300,303,304,321,322,324,325,3
26,328,483,484,485,486,487
6941.1074981021.19435412.6290.6802510.7117960.8159351.6602060.5298413.1334060.96704Chain A: 16,19,20,23,24,26,27,29,76,77,106,108,129
,132,133,142,144,148,151,153,158,159,160,161,162,1
64,878
7071.0483771.066768.6630.4380.7610.9970.8021.0140.7910.658Chain A: 192,218,219,220,221,224,229,230,231,232,2
34,235,236,237,238,239,240,241,244,245,258,259,260
,261,266,267,329,330,333,334,336,337,338,341,342,3
51,355,358,359,376,377,379,380,381,383,538,539,540
,541,542,543,544,545,546
7201.08322331.096396.5080.39950.81821.07531.12341.02731.09360.7176Chain A: 72,75,76,101,102,103,159,160,161,162,163,
189,192,193,194,195,221,222,223,226,227,228,247,24
8,249,250,280,281,282,284,286,287,304,305,306,324,
325,326,406,419,421,422

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore
720ZINC000000121541DB00643Mebendazole-8.63597-9.31867
720ZINC000068247389DB12483Copanlisib-8.42822-8.85532
720ZINC000000000655DB01058Praziquantel-8.78817-8.78817
720ZINC000029571072DB06636Isavuconazonium-6.98077-8.75307
720ZINC000003964126DB06228Rivaroxaban-8.69525-8.69525
720ZINC000040430143DB09074Olaparib-8.60124-8.60124
720ZINC000004099200DB00213Pantoprazole-8.08373-8.38543
720ZINC000003802690DB00442Entecavir-8.3393-8.3393
720ZINC000000020220DB00537Ciprofloxacin-7.23159-8.33599
720ZINC000002008866DB00601Linezolid-8.28785-8.28785
720ZINC000100378061DB11691Naldemedine-7.92656-8.28096
720ZINC000043206370DB11793Niraparib-8.03337-8.03337
720ZINC000000000850DB00744Zileuton-7.99829-8.01689
720ZINC000000968328DB00412Rosiglitazone-7.44757-7.97177
720ZINC000098023177DB09330Osimertinib-7.86467-7.87237
720ZINC000011616882DB06626Axitinib-7.8458-7.849
720ZINC000000000973DB09495Avobenzone-7.48205-7.80725
720NetarsudilDB09495-7.79041-7.80151
720ZINC000019796080DB00450Droperidol-7.69718-7.79558
720ZINC000000005560DB01009Ketoprofen-7.79303-7.79353

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group
ZINC000000121541DB00643MebendazoleSmall moleculeCOC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C1=CC=CC=C1Approved|Vet_approved
ZINC000068247389DB12483CopanlisibSmall moleculeCOC1=C(OCCCN2CCOCC2)C=CC2=C1N=C(NC(=O)C1=CN=C(N)N=C1)N1CCN=C21Approved|Investigational
ZINC000003964126DB06228RivaroxabanSmall moleculeClC1=CC=C(S1)C(=O)NC[C@H]1CN(C(=O)O1)C1=CC=C(C=C1)N1CCOCC1=OApproved
ZINC000040430143DB09074OlaparibSmall moleculeFC1=CC=C(CC2=NNC(=O)C3=CC=CC=C23)C=C1C(=O)N1CCN(CC1)C(=O)C1CC1Approved
ZINC000003802690DB00442EntecavirSmall moleculeNC1=NC(=O)C2=C(N1)N(C=N2)[C@H]1C[C@H](O)[C@@H](CO)C1=CApproved|Investigational
ZINC000000020220DB00537CiprofloxacinSmall moleculeOC(=O)C1=CN(C2CC2)C2=CC(N3CCNCC3)=C(F)C=C2C1=OApproved|Investigational
ZINC000002008866DB00601LinezolidSmall moleculeCC(=O)NC[C@H]1CN(C(=O)O1)C1=CC(F)=C(C=C1)N1CCOCC1Approved|Investigational
ZINC000100378061DB11691NaldemedineSmall molecule[H][C@@]12OC3=C4C(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)CC(C(=O)NC(C)(C)C1=NC(=NO1)C1=CC=CC=C1)=C2O)=CC=C3OApproved|Investigational
ZINC000043206370DB11793NiraparibSmall moleculeNC(=O)C1=CC=CC2=CN(N=C12)C1=CC=C(C=C1)[C@@H]1CCCNC1Approved|Investigational
ZINC000098023177DB09330OsimertinibSmall moleculeCOC1=C(NC2=NC=CC(=N2)C2=CN(C)C3=C2C=CC=C3)C=C(NC(=O)C=C)C(=C1)N(C)CCN(C)CApproved
ZINC000011616882DB06626AxitinibSmall moleculeCNC(=O)C1=C(SC2=CC=C3C(NN=C3C=CC3=CC=CC=N3)=C2)C=CC=C1Approved|Investigational
ZINC000000000973DB09495AvobenzoneSmall moleculeCOC1=CC=C(C=C1)C(=O)CC(=O)C1=CC=C(C=C1)C(C)(C)CApproved|Investigational
ZINC000019796080DB00450DroperidolSmall moleculeFC1=CC=C(C=C1)C(=O)CCCN1CCC(=CC1)N1C(=O)NC2=CC=CC=C12Approved|Vet_approved

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three
ZINC000000121541295.2976.562576.16198.468169.387308.3060957.18158.911383.64100
ZINC000000121541295.2972.873577.03396.773172.83307.430959.022038.668388.18700
ZINC000000121541295.29710.919575.19998.469170.072306.6580956.419158.861383.46100
ZINC000000000655312.4118.136587.283357.50579.355150.42401051.38069.514385.55500
ZINC000003964126435.88114.098691.698245.278129.622200.433116.3641226.142110.78.72389.64600
ZINC000040430143434.4699.89732.917311167.143218.80935.9651326.981189.389383.35900
ZINC000004099200383.3698.318623.128213.24477.412222.302110.171084.47189.124376.69200
ZINC000004099200383.3698.299620.121215.6578.983216.916108.5731082.558189.183376.22100
ZINC000004099200383.3698.355619.5212.86177.163219.295110.1821080.981189.019376.60300
ZINC000004099200383.3698.428625.396215.33578.49221.055110.5161084.724189.007376.45900
ZINC000003802690277.2826.742504.225143.129289.37471.7210851.66258.98.512242.61301
ZINC000000020220331.3468.67578.412299.833178.53968.48731.5531017.371168.925248.3301
ZINC000000020220331.3468.111575.511298.04176.66769.24631.5581012.813168.79248.64801
ZINC000002008866337.3511.384587.905370.55399.01286.52531.8151034.05818.78.411380.73200
ZINC000100378061570.6447.56854.021394.296164.643295.08101642.452210.758.853262.78110
ZINC000100378061570.6448.331882.482435.335156.89290.25701665.202210.758.834264.4810
ZINC000100378061570.64410.805763.051379.112156.9227.03901550.783210.758.848360.84410
ZINC000100378061570.6446.025879.032420.86169.846288.32601665.947210.758.837262.17110
ZINC000100378061570.6445.057763.557369.607150.289243.66101542.60727.758.754374.61510
ZINC000100378061570.64410.054868.556406.179167.203295.17401648.407210.758.918262.16610
ZINC000100378061570.6445.965873.468425.996156.952290.5201657.709210.758.842264.59410
ZINC000100378061570.6448.012750.848378.176172.899199.77201535.75227.758.801369.36110
ZINC000100378061570.6447.635772.058387.087130.302254.66901568.531210.758.606367.33410
ZINC000100378061570.6445.989867.147425.966151.587289.59501651.992210.758.574265.46310
ZINC000100378061570.6448.675845.172419.952137.137288.08301633.122210.758.655368.33310
ZINC000100378061570.6445.076883.549427.334168.007288.20901671.805210.758.637262.81210
ZINC000100378061570.6446.815864.11391.791178.38293.9401641.25227.758.82172.38811
ZINC000043206370320.3933.754607.688185.794143.417278.47601055.805358.546376.7200
ZINC000000000850236.2885.297457.64285.783137.035198.52336.3755.01533.78.91375.35100
ZINC000000000850236.2885.297450.83785.532135.419201.89327.994746.83933.78.57376.55500
ZINC000000968328357.4261.444634.074175.676137.918287.73532.7451113.73115.258.373396.01200
ZINC000000968328357.4262.563632.369175.708136.258287.71932.6841111.85315.258.348396.29400
ZINC000000968328357.4261.098615.115188.498120.189271.1535.2791101.06815.258.417310000
ZINC000000968328357.4264.059637.846177.05121.495296.23443.0671111.87615.258.521310000
ZINC000098023177499.6144.129911.961486.02562.254363.68101655.00328.757.891195.18511
ZINC000011616882386.475.573701.348134.58997.85441.45327.4561225.03824.58.259110001
ZINC000000000973310.3926.186619.54304.39482.62232.52601088.97404.759.463310000
ZINC000000000973310.3926.564618.531285.76972.419260.34301082.17802.59.061310000
ZINC000000000973310.3927.653619.32285.59272.423261.30501082.95402.59.142310000
ZINC000000000973310.3923.937616.628300.43870.725245.46501078.24502.59.238310000
ZINC000019796080379.4335.336690.754177.289126.948339.68946.8281214.622168.72386.62500
ZINC000019796080379.4334.227703.161188.25122.749345.33746.8251231.012168.619387.34500
ZINC000019796080379.4336.26700.949186.412123.449344.26346.8251227.254168.598387.21500
ZINC000000005560254.2855.998511.94584.096135.311292.5380867.146149.894383.08900


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity
ZINC000000121541COC(=O)/N=c1[nH]c2ccc(C(=O)c3ccccc3)cc2[nH]10.2096963420.592445172
ZINC000068247389COc1c(OCCCN2CCOCC2)ccc2c1N=C(/N=C(O)c1cnc(N)nc1)N1CCN=C210.0956681620.218817189
ZINC000000000655O=C(C1CCCCC1)N1CC(=O)N2CCc3ccccc3[C@@H]2C10.1809979670.220112088
ZINC000029571072CNCC(=O)OCc1cccnc1N(C)C(=O)O[C@H](C)[n+]1cnn(C[C@](O)(c2cc(F)ccc2F)[C@@H](C)c2nc(-c3ccc(C#N)cc3)cs2)c10.0254160270.235213823
ZINC000003964126O=C(NC[C@H]1CN(c2ccc(N3CCOCC3=O)cc2)C(=O)O1)c1ccc(Cl)s10.1363374890.314484681
ZINC000040430143O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(C(=O)C2CC2)CC10.2543148970.146669648
ZINC000004099200COc1ccnc(C[S@](=O)c2nc3ccc(OC(F)F)cc3[nH]2)c1OC0.1146673540.321842622
ZINC000003802690C=C1[C@@H](n2cnc3c(=O)[nH]c(N)nc32)C[C@H](O)[C@H]1CO0.0456937720.309972869
ZINC000000020220O=C(O)c1cn(C2CC2)c2cc(N3CCNCC3)c(F)cc2c1=O0.2310316290.323908212
ZINC000002008866CC(=O)NC[C@H]1CN(c2ccc(N3CCOCC3)c(F)c2)C(=O)O10.1721880250.409724838
ZINC000100378061CC(C)(NC(=O)C1=C(O)[C@@H]2Oc3c(O)ccc4c3[C@@]23CCN(CC2CC2)[C@H](C4)[C@]3(O)C1)c1nc(-c2ccccc2)no10.0108828180.206042928
ZINC000043206370NC(=O)c1cccc2cn(-c3ccc([C@@H]4CCCNC4)cc3)nc120.158103060.243905197
ZINC000000000850C[C@@H](c1cc2ccccc2s1)N(O)C(N)=O0.1363358820.223511692
ZINC000000968328CN(CCOc1ccc(C[C@@H]2SC(=O)NC2=O)cc1)c1ccccn10.1553268710.273380926
ZINC000098023177C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C0.145924440.194338203
ZINC000011616882CNC(=O)c1ccccc1Sc1ccc2c(/C=Cc3ccccn3)n[nH]c2c10.198742650.230949688
ZINC000000000973COc1ccc(C(=O)CC(=O)c2ccc(C(C)(C)C)cc2)cc10.4499677640.531455882
ZINC000019796080O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc10.2197276360.259906112
ZINC000000005560C[C@H](C(=O)O)c1cccc(C(=O)c2ccccc2)c10.3177642630.285932087


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
HACL1ZMYND19, HACL1, MAPK6, FAM162A, PEX5, MAGEB6, GMPPB, PTPRF, WDFY1, ASPSCR1, PLXDC2, ODF2L, RNA15, CAT, APEX1, ANLN, ECT2, KIF20A, AGPS, CCNF, NBR1,
RAF1YWHAQ, YWHAG, YWHAZ, Hras, SFN, HRAS, VDAC1, PEBP4, CNKSR1, RASD2, CNKSR2, ERAS, SPRY4, SPRY2, YWHAB, OIP5, PHKA2, CCT3, MYC, AR, MRAS, KRAS, LRPAP1, RRAS2, SHOC2, TSC22D3, STK26, MAPK1, MAPK3, PRKCE, BCL2, BCL2L1, PEBP1, MAP2K1, GRB10, NRAS, MAPK8IP3, AKT1, HSP90AA1, GNG4, GNB2, VAV1, RHEB, RAP1A, SRC, FYN, RB1, RBL2, PRKG1, JAK2, YWHAH, CFLAR, CDC25A, BRAF, MAP3K1, PDGFRB, MAP3K5, MAPK7, PHB, BAG1, PAK1, PRKCZ, RRAS, PRPF6, UBE2D2, YWHAE, NR3C1, LCK, LTK, JAK1, XIAP, BIRC2, BIRC3, STUB1, Arrb2, EEF1A1, HSP82, HSPA8, HSPA5, CALM1, SGK1, NEDD4, SCNN1B, NEDD4L, STK3, BRAP, WDR83, KSR1, LATS1, MAP2K2, Rfxank, RFXANK, PPP1CC, VCP, HSPD1, BAD, BCL6, BIRC7, PIN1, MMS19, PPP2R1A, PPP2R2B, PPP2CA, HSPA4, RAF1, PPP2CB, MAPK8, RBBP8, YY1, PKM, CDK20, HIPK4, TBXA2R, SH3KBP1, ILK, GPRASP2, CDC37, IRS4, FAM96B, HUWE1, Prkab1, RANBP9, TMEM70, PACSIN3, NPLOC4, PRKAR1A, DCAF8, PURA, FYCO1, MYBPC1, COPS7A, MOV10, NXF1, EGFR, CALU, CCT8, DNAJA1, EMD, TIMM50, LOX, ARRB2, AGTR1, CASZ1, MRC2, PDLIM2, HERC2, XPO1, ACOX1, PCDH7, MAD2L1, SYNPO, TMEM63B, EEF1E1, COPS5, SS18L2, Smn1, Cep152, Aldh4a1, Ksr1, NUP133, RPGRIP1L, NCAPG2, NUP107, MSH2, LAS1L, AMER1, NUP160, EIF3D, SPATA7, NPHP4, DYNLL2, DYNLL1, IQCB1, RMDN3, TRIM25, Mapkbp1, EGLN3, RIPK4, MAPK6, CSNK1A1, HERC1, LZTR1, QKI, COPS3, TRIM28, MAEA, NANOG, ITCH, IRF7, PSMB9, MAP2K5, CDK4, CDK6, CDKN2B, FGFR4, MAP2K3, NF2, PDGFRA, TEAD2, RASSF1, ABCB5, BECN1, CBLC, GLIS2, GRM1, HGF, MAP2K6, ARNT, CCND2, CD44, CDKN2A, CDKN2C, EPHA2, ERBB2, KEAP1, LATS2, MET, NF1, TERT, DUSP2, MBP, PAK2, PLEKHA4, CRBN, ARAF, SLC25A3, TUBB4B, TUBB, HSPA6, HSP90AB3P, HSP90AB1, HSPA1A, HSPB1, BAG2, CCT7, DSG1, CCT2, CCT4, CCT6A, TCP1, AKAP8L, ATAD3A, ABCD3, SLC25A22, TMEM33, TUBA4A, HPX, MGST1, TUBB4A, TMEM161A, HSP90AB2P, CCAR2, SLC25A10, FANCD2, TUBB6, HSD17B12, SLC25A11, SLC25A1, ARL1, DNAJA2, DPM1, CCT5, AIFM1, SQSTM1, TUBG2, TUBG1, STK39, GCN1L1, ABCF2, POLD1, NUBP2, TM9SF3, NCLN, SEC61A2, SEC61A1, ALDH1A3, TUBB3, POLR2B, IARS2, TMED1, CIT, AURKB, KIF20A, BRD1, TRIM66, HAX1, CUL4A, ACTR1A, AKAP1, FLOT1, LAMTOR1, LMAN1, RAB2A, RAB4A, STX7, NPAS1, OPALIN, METTL21B, SSSCA1, FAM174A, CRKL, DDB1, DICER1, LDHB, PIK3R1, NONO, DVL2,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
HACL1all structure
RAF1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to HACL1-RAF1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to HACL1-RAF1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
HACL1RAF1Dendritic Cell TumorMyCancerGenome
HACL1RAF1Not Otherwise SpecifiedMyCancerGenome
HACL1RAF1Esophageal AdenocarcinomaMyCancerGenome
HACL1RAF1Gastric AdenocarcinomaMyCancerGenome
HACL1RAF1GlioblastomaMyCancerGenome
HACL1RAF1High-Grade GliomaMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHACL1C0008370Cholestasis1CTD_human
HgeneHACL1C0019193Hepatitis, Toxic1CTD_human
HgeneHACL1C0860207Drug-Induced Liver Disease1CTD_human
HgeneHACL1C1262760Hepatitis, Drug-Induced1CTD_human
HgeneHACL1C3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneHACL1C4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneHACL1C4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneRAF1C0028326Noonan Syndrome10CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneRAF1C0175704LEOPARD Syndrome7CLINGEN;CTD_human;GENOMICS_ENGLAND
TgeneRAF1C1969057Noonan Syndrome 54CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneRAF1C1969056LEOPARD SYNDROME 23CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneRAF1C0007194Hypertrophic Cardiomyopathy2CTD_human
TgeneRAF1C0041409Turner Syndrome, Male2CTD_human
TgeneRAF1C1519086Pilomyxoid astrocytoma2ORPHANET
TgeneRAF1C1527404Female Pseudo-Turner Syndrome2CTD_human
TgeneRAF1C4551472Hypertrophic obstructive cardiomyopathy2CTD_human
TgeneRAF1C4551602Noonan Syndrome 12CTD_human
TgeneRAF1C0006142Malignant neoplasm of breast1CTD_human
TgeneRAF1C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneRAF1C0007193Cardiomyopathy, Dilated1CTD_human
TgeneRAF1C0017638Glioma1CTD_human
TgeneRAF1C0020429Hyperalgesia1CTD_human
TgeneRAF1C0022665Kidney Neoplasm1CTD_human
TgeneRAF1C0023903Liver neoplasms1CTD_human
TgeneRAF1C0024121Lung Neoplasms1CTD_human
TgeneRAF1C0242379Malignant neoplasm of lung1CTD_human
TgeneRAF1C0259783mixed gliomas1CTD_human
TgeneRAF1C0340427Familial dilated cardiomyopathy1ORPHANET
TgeneRAF1C0345904Malignant neoplasm of liver1CTD_human
TgeneRAF1C0345967Malignant mesothelioma1CTD_human
TgeneRAF1C0458247Allodynia1CTD_human
TgeneRAF1C0555198Malignant Glioma1CTD_human
TgeneRAF1C0587248Costello syndrome (disorder)1CLINGEN
TgeneRAF1C0678222Breast Carcinoma1CTD_human
TgeneRAF1C0740457Malignant neoplasm of kidney1CTD_human
TgeneRAF1C0751211Hyperalgesia, Primary1CTD_human
TgeneRAF1C0751212Hyperalgesia, Secondary1CTD_human
TgeneRAF1C0751213Tactile Allodynia1CTD_human
TgeneRAF1C0751214Hyperalgesia, Thermal1CTD_human
TgeneRAF1C1257931Mammary Neoplasms, Human1CTD_human
TgeneRAF1C1275081Cardio-facio-cutaneous syndrome1CLINGEN
TgeneRAF1C1449563Cardiomyopathy, Familial Idiopathic1CTD_human
TgeneRAF1C1458155Mammary Neoplasms1CTD_human
TgeneRAF1C2936719Mechanical Allodynia1CTD_human
TgeneRAF1C4014656CARDIOMYOPATHY, DILATED, 1NN1CTD_human;UNIPROT
TgeneRAF1C4551484Leopard Syndrome 11CTD_human;GENOMICS_ENGLAND
TgeneRAF1C4704874Mammary Carcinoma, Human1CTD_human
TgeneRAF1C4721610Carcinoma, Ovarian Epithelial1CTD_human