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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:HEATR2-ZNRF3

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: HEATR2-ZNRF3
	FusionPDB ID: 35956
	FusionGDB2.0 ID: 35956
		Hgene	Tgene
	Gene symbol	HEATR2	ZNRF3
	Gene ID	54919	84133
	Gene name	dynein axonemal assembly factor 5	zinc and ring finger 3
	Synonyms	CILD18\|HEATR2	BK747E2.3\|RNF203
	Cytomap	7p22.3	22q12.1
	Type of gene	protein-coding	protein-coding
	Description	dynein assembly factor 5, axonemalHEAT repeat containing 2HEAT repeat-containing protein 2	E3 ubiquitin-protein ligase ZNRF3CTA-292E10.6RING finger protein 203RING-type E3 ubiquitin transferase ZNRF3novel C3HC4 type Zinc finger (ring finger)zinc/RING finger protein 3
	Modification date	20200313	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000438961, ENST00000297440, ENST00000313147, ENST00000403952,	ENST00000332811, ENST00000402174, ENST00000406323, ENST00000544604,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	6 X 2 X 5=60	16 X 21 X 8=2688
	# samples	6	21
	** MAII score	log2(6/60*10)=0	log2(21/2688*10)=-3.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: HEATR2 [Title/Abstract] AND ZNRF3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	HEATR2(769484)-ZNRF3(29442704), # samples:1
Anticipated loss of major functional domain due to fusion event.	HEATR2-ZNRF3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HEATR2-ZNRF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ZNRF3	GO:0016567	protein ubiquitination	22575959

Fusion gene breakpoints across HEATR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ZNRF3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-FD-A3B6-01A	HEATR2	chr7	769484	-	ZNRF3	chr22	29442704	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000297440	HEATR2	chr7	769484	-	ENST00000544604	ZNRF3	chr22	29442704	+	6732	800	20	2866	948
ENST00000297440	HEATR2	chr7	769484	-	ENST00000332811	ZNRF3	chr22	29442704	+	6732	800	20	2866	948
ENST00000297440	HEATR2	chr7	769484	-	ENST00000402174	ZNRF3	chr22	29442704	+	2930	800	20	2866	948
ENST00000297440	HEATR2	chr7	769484	-	ENST00000406323	ZNRF3	chr22	29442704	+	3210	800	20	2866	948
ENST00000313147	HEATR2	chr7	769484	-	ENST00000544604	ZNRF3	chr22	29442704	+	6732	800	20	2866	948
ENST00000313147	HEATR2	chr7	769484	-	ENST00000332811	ZNRF3	chr22	29442704	+	6732	800	20	2866	948
ENST00000313147	HEATR2	chr7	769484	-	ENST00000402174	ZNRF3	chr22	29442704	+	2930	800	20	2866	948
ENST00000313147	HEATR2	chr7	769484	-	ENST00000406323	ZNRF3	chr22	29442704	+	3210	800	20	2866	948

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000297440	ENST00000544604	HEATR2	chr7	769484	-	ZNRF3	chr22	29442704	+	0.003168671	0.99683136
ENST00000297440	ENST00000332811	HEATR2	chr7	769484	-	ZNRF3	chr22	29442704	+	0.003168671	0.99683136
ENST00000297440	ENST00000402174	HEATR2	chr7	769484	-	ZNRF3	chr22	29442704	+	0.027311513	0.97268856
ENST00000297440	ENST00000406323	HEATR2	chr7	769484	-	ZNRF3	chr22	29442704	+	0.016151177	0.9838488
ENST00000313147	ENST00000544604	HEATR2	chr7	769484	-	ZNRF3	chr22	29442704	+	0.003168671	0.99683136
ENST00000313147	ENST00000332811	HEATR2	chr7	769484	-	ZNRF3	chr22	29442704	+	0.003168671	0.99683136
ENST00000313147	ENST00000402174	HEATR2	chr7	769484	-	ZNRF3	chr22	29442704	+	0.027311513	0.97268856
ENST00000313147	ENST00000406323	HEATR2	chr7	769484	-	ZNRF3	chr22	29442704	+	0.016151177	0.9838488

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>35956_35956_1_HEATR2-ZNRF3_HEATR2_chr7_769484_ENST00000297440_ZNRF3_chr22_29442704_ENST00000332811_length(amino acids)=948AA_BP=259
MAALGVAEAVAAPHPAEGAETAEAVELSRALSRLLPGLEADSKPGRRRALEALRRALEEPGPAADPTAFQGPWARLLLPRLLRCLSDPAE
GCRALAVHLLDLGLRRAARPRDALPRLLPALAARLAGPVPARRPPEACEELRLALVQLLGLAVDLCGAALAPHLDDALRALRCSLLDPFA
AVRRESCSCAAALAQATPDHFHMQSESLIGPLMQTISHQHWKVRVAAIEATGAVIHFGNGKSVDDVLSHFAQRLFDDVPQNSMNRLAVQA
LEKMETRKFNSKSKGRREGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPSAVC
VETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVTLLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHR
AYSPAHPFRRPKLSGRSFSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHVAPPSHLESGSTSS
FSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGR
GPALCFEGSPPPEELPAVHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAPDLRRTWKGGHELP
SCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSSQGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCY
TEDYSVSVQYTLTEEPPPGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATREEERALCCQARALL

--------------------------------------------------------------

>35956_35956_2_HEATR2-ZNRF3_HEATR2_chr7_769484_ENST00000297440_ZNRF3_chr22_29442704_ENST00000402174_length(amino acids)=948AA_BP=259
MAALGVAEAVAAPHPAEGAETAEAVELSRALSRLLPGLEADSKPGRRRALEALRRALEEPGPAADPTAFQGPWARLLLPRLLRCLSDPAE
GCRALAVHLLDLGLRRAARPRDALPRLLPALAARLAGPVPARRPPEACEELRLALVQLLGLAVDLCGAALAPHLDDALRALRCSLLDPFA
AVRRESCSCAAALAQATPDHFHMQSESLIGPLMQTISHQHWKVRVAAIEATGAVIHFGNGKSVDDVLSHFAQRLFDDVPQNSMNRLAVQA
LEKMETRKFNSKSKGRREGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPSAVC
VETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVTLLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHR
AYSPAHPFRRPKLSGRSFSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHVAPPSHLESGSTSS
FSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGR
GPALCFEGSPPPEELPAVHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAPDLRRTWKGGHELP
SCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSSQGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCY
TEDYSVSVQYTLTEEPPPGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATREEERALCCQARALL

--------------------------------------------------------------

>35956_35956_3_HEATR2-ZNRF3_HEATR2_chr7_769484_ENST00000297440_ZNRF3_chr22_29442704_ENST00000406323_length(amino acids)=948AA_BP=259
MAALGVAEAVAAPHPAEGAETAEAVELSRALSRLLPGLEADSKPGRRRALEALRRALEEPGPAADPTAFQGPWARLLLPRLLRCLSDPAE
GCRALAVHLLDLGLRRAARPRDALPRLLPALAARLAGPVPARRPPEACEELRLALVQLLGLAVDLCGAALAPHLDDALRALRCSLLDPFA
AVRRESCSCAAALAQATPDHFHMQSESLIGPLMQTISHQHWKVRVAAIEATGAVIHFGNGKSVDDVLSHFAQRLFDDVPQNSMNRLAVQA
LEKMETRKFNSKSKGRREGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPSAVC
VETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVTLLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHR
AYSPAHPFRRPKLSGRSFSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHVAPPSHLESGSTSS
FSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGR
GPALCFEGSPPPEELPAVHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAPDLRRTWKGGHELP
SCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSSQGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCY
TEDYSVSVQYTLTEEPPPGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATREEERALCCQARALL

--------------------------------------------------------------

>35956_35956_4_HEATR2-ZNRF3_HEATR2_chr7_769484_ENST00000297440_ZNRF3_chr22_29442704_ENST00000544604_length(amino acids)=948AA_BP=259
MAALGVAEAVAAPHPAEGAETAEAVELSRALSRLLPGLEADSKPGRRRALEALRRALEEPGPAADPTAFQGPWARLLLPRLLRCLSDPAE
GCRALAVHLLDLGLRRAARPRDALPRLLPALAARLAGPVPARRPPEACEELRLALVQLLGLAVDLCGAALAPHLDDALRALRCSLLDPFA
AVRRESCSCAAALAQATPDHFHMQSESLIGPLMQTISHQHWKVRVAAIEATGAVIHFGNGKSVDDVLSHFAQRLFDDVPQNSMNRLAVQA
LEKMETRKFNSKSKGRREGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPSAVC
VETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVTLLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHR
AYSPAHPFRRPKLSGRSFSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHVAPPSHLESGSTSS
FSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGR
GPALCFEGSPPPEELPAVHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAPDLRRTWKGGHELP
SCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSSQGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCY
TEDYSVSVQYTLTEEPPPGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATREEERALCCQARALL

--------------------------------------------------------------

>35956_35956_5_HEATR2-ZNRF3_HEATR2_chr7_769484_ENST00000313147_ZNRF3_chr22_29442704_ENST00000332811_length(amino acids)=948AA_BP=259
MAALGVAEAVAAPHPAEGAETAEAVELSRALSRLLPGLEADSKPGRRRALEALRRALEEPGPAADPTAFQGPWARLLLPRLLRCLSDPAE
GCRALAVHLLDLGLRRAARPRDALPRLLPALAARLAGPVPARRPPEACEELRLALVQLLGLAVDLCGAALAPHLDDALRALRCSLLDPFA
AVRRESCSCAAALAQATPDHFHMQSESLIGPLMQTISHQHWKVRVAAIEATGAVIHFGNGKSVDDVLSHFAQRLFDDVPQNSMNRLAVQA
LEKMETRKFNSKSKGRREGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPSAVC
VETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVTLLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHR
AYSPAHPFRRPKLSGRSFSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHVAPPSHLESGSTSS
FSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGR
GPALCFEGSPPPEELPAVHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAPDLRRTWKGGHELP
SCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSSQGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCY
TEDYSVSVQYTLTEEPPPGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATREEERALCCQARALL

--------------------------------------------------------------

>35956_35956_6_HEATR2-ZNRF3_HEATR2_chr7_769484_ENST00000313147_ZNRF3_chr22_29442704_ENST00000402174_length(amino acids)=948AA_BP=259
MAALGVAEAVAAPHPAEGAETAEAVELSRALSRLLPGLEADSKPGRRRALEALRRALEEPGPAADPTAFQGPWARLLLPRLLRCLSDPAE
GCRALAVHLLDLGLRRAARPRDALPRLLPALAARLAGPVPARRPPEACEELRLALVQLLGLAVDLCGAALAPHLDDALRALRCSLLDPFA
AVRRESCSCAAALAQATPDHFHMQSESLIGPLMQTISHQHWKVRVAAIEATGAVIHFGNGKSVDDVLSHFAQRLFDDVPQNSMNRLAVQA
LEKMETRKFNSKSKGRREGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPSAVC
VETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVTLLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHR
AYSPAHPFRRPKLSGRSFSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHVAPPSHLESGSTSS
FSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGR
GPALCFEGSPPPEELPAVHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAPDLRRTWKGGHELP
SCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSSQGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCY
TEDYSVSVQYTLTEEPPPGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATREEERALCCQARALL

--------------------------------------------------------------

>35956_35956_7_HEATR2-ZNRF3_HEATR2_chr7_769484_ENST00000313147_ZNRF3_chr22_29442704_ENST00000406323_length(amino acids)=948AA_BP=259
MAALGVAEAVAAPHPAEGAETAEAVELSRALSRLLPGLEADSKPGRRRALEALRRALEEPGPAADPTAFQGPWARLLLPRLLRCLSDPAE
GCRALAVHLLDLGLRRAARPRDALPRLLPALAARLAGPVPARRPPEACEELRLALVQLLGLAVDLCGAALAPHLDDALRALRCSLLDPFA
AVRRESCSCAAALAQATPDHFHMQSESLIGPLMQTISHQHWKVRVAAIEATGAVIHFGNGKSVDDVLSHFAQRLFDDVPQNSMNRLAVQA
LEKMETRKFNSKSKGRREGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPSAVC
VETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVTLLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHR
AYSPAHPFRRPKLSGRSFSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHVAPPSHLESGSTSS
FSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGR
GPALCFEGSPPPEELPAVHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAPDLRRTWKGGHELP
SCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSSQGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCY
TEDYSVSVQYTLTEEPPPGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATREEERALCCQARALL

--------------------------------------------------------------

>35956_35956_8_HEATR2-ZNRF3_HEATR2_chr7_769484_ENST00000313147_ZNRF3_chr22_29442704_ENST00000544604_length(amino acids)=948AA_BP=259
MAALGVAEAVAAPHPAEGAETAEAVELSRALSRLLPGLEADSKPGRRRALEALRRALEEPGPAADPTAFQGPWARLLLPRLLRCLSDPAE
GCRALAVHLLDLGLRRAARPRDALPRLLPALAARLAGPVPARRPPEACEELRLALVQLLGLAVDLCGAALAPHLDDALRALRCSLLDPFA
AVRRESCSCAAALAQATPDHFHMQSESLIGPLMQTISHQHWKVRVAAIEATGAVIHFGNGKSVDDVLSHFAQRLFDDVPQNSMNRLAVQA
LEKMETRKFNSKSKGRREGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPSAVC
VETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVTLLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHR
AYSPAHPFRRPKLSGRSFSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHVAPPSHLESGSTSS
FSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGR
GPALCFEGSPPPEELPAVHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAPDLRRTWKGGHELP
SCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSSQGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCY
TEDYSVSVQYTLTEEPPPGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATREEERALCCQARALL

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:769484/chr22:29442704)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HEATR2

chr7:769484

chr22:29442704

ENST00000297440

202_240

260.0

856.0

Repeat

Note=HEAT 2

Hgene

HEATR2

chr7:769484

chr22:29442704

ENST00000297440

71_109

260.0

856.0

Repeat

Note=HEAT 1

Hgene

HEATR2

chr7:769484

chr22:29442704

ENST00000313147

202_240

260.0

844.0

Repeat

Note=HEAT 2

Hgene

HEATR2

chr7:769484

chr22:29442704

ENST00000313147

71_109

260.0

844.0

Repeat

Note=HEAT 1

Tgene

ZNRF3

chr7:769484

chr22:29442704

ENST00000332811

241_936

148.0

837.0

Topological domain

Cytoplasmic

Tgene

ZNRF3

chr7:769484

chr22:29442704

ENST00000402174

241_936

148.0

837.0

Topological domain

Cytoplasmic

Tgene

ZNRF3

chr7:769484

chr22:29442704

ENST00000406323

241_936

148.0

837.0

Topological domain

Cytoplasmic

Tgene

ZNRF3

chr7:769484

chr22:29442704

ENST00000332811

220_240

148.0

837.0

Transmembrane

Helical

Tgene

ZNRF3

chr7:769484

chr22:29442704

ENST00000402174

220_240

148.0

837.0

Transmembrane

Helical

Tgene

ZNRF3

chr7:769484

chr22:29442704

ENST00000406323

220_240

148.0

837.0

Transmembrane

Helical

Tgene

ZNRF3

chr7:769484

chr22:29442704

ENST00000332811

293_334

148.0

837.0

Zinc finger

RING-type%3B atypical

Tgene

ZNRF3

chr7:769484

chr22:29442704

ENST00000402174

293_334

148.0

837.0

Zinc finger

RING-type%3B atypical

Tgene

ZNRF3

chr7:769484

chr22:29442704

ENST00000406323

293_334

148.0

837.0

Zinc finger

RING-type%3B atypical

Tgene

ZNRF3

chr7:769484

chr22:29442704

ENST00000544604

293_334

248.0

937.0

Zinc finger

RING-type%3B atypical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HEATR2

chr7:769484

chr22:29442704

ENST00000297440

241_278

260.0

856.0

Repeat

Note=HEAT 3

Hgene

HEATR2

chr7:769484

chr22:29442704

ENST00000297440

280_318

260.0

856.0

Repeat

Note=HEAT 4

Hgene

HEATR2

chr7:769484

chr22:29442704

ENST00000297440

354_376

260.0

856.0

Repeat

Note=HEAT 5

Hgene

HEATR2

chr7:769484

chr22:29442704

ENST00000297440

377_414

260.0

856.0

Repeat

Note=HEAT 6

Hgene

HEATR2

chr7:769484

chr22:29442704

ENST00000297440

599_638

260.0

856.0

Repeat

Note=HEAT 7

Hgene

HEATR2

chr7:769484

chr22:29442704

ENST00000297440

696_734

260.0

856.0

Repeat

Note=HEAT 8

Hgene

HEATR2

chr7:769484

chr22:29442704

ENST00000297440

738_776

260.0

856.0

Repeat

Note=HEAT 9

Hgene

HEATR2

chr7:769484

chr22:29442704

ENST00000297440

784_822

260.0

856.0

Repeat

Note=HEAT 10

Hgene

HEATR2

chr7:769484

chr22:29442704

ENST00000313147

241_278

260.0

844.0

Repeat

Note=HEAT 3

Hgene

HEATR2

chr7:769484

chr22:29442704

ENST00000313147

280_318

260.0

844.0

Repeat

Note=HEAT 4

Hgene

HEATR2

chr7:769484

chr22:29442704

ENST00000313147

354_376

260.0

844.0

Repeat

Note=HEAT 5

Hgene

HEATR2

chr7:769484

chr22:29442704

ENST00000313147

377_414

260.0

844.0

Repeat

Note=HEAT 6

Hgene

HEATR2

chr7:769484

chr22:29442704

ENST00000313147

599_638

260.0

844.0

Repeat

Note=HEAT 7

Hgene

HEATR2

chr7:769484

chr22:29442704

ENST00000313147

696_734

260.0

844.0

Repeat

Note=HEAT 8

Hgene

HEATR2

chr7:769484

chr22:29442704

ENST00000313147

738_776

260.0

844.0

Repeat

Note=HEAT 9

Hgene

HEATR2

chr7:769484

chr22:29442704

ENST00000313147

784_822

260.0

844.0

Repeat

Note=HEAT 10

Tgene

ZNRF3

chr7:769484

chr22:29442704

ENST00000332811

56_219

148.0

837.0

Topological domain

Extracellular

Tgene

ZNRF3

chr7:769484

chr22:29442704

ENST00000402174

56_219

148.0

837.0

Topological domain

Extracellular

Tgene

ZNRF3

chr7:769484

chr22:29442704

ENST00000406323

56_219

148.0

837.0

Topological domain

Extracellular

Tgene

ZNRF3

chr7:769484

chr22:29442704

ENST00000544604

241_936

248.0

937.0

Topological domain

Cytoplasmic

Tgene

ZNRF3

chr7:769484

chr22:29442704

ENST00000544604

56_219

248.0

937.0

Topological domain

Extracellular

Tgene

ZNRF3

chr7:769484

chr22:29442704

ENST00000544604

220_240

248.0

937.0

Transmembrane

Helical

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
HEATR2
ZNRF3

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to HEATR2-ZNRF3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to HEATR2-ZNRF3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source