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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:HIPK2-PARP12

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: HIPK2-PARP12
	FusionPDB ID: 36412
	FusionGDB2.0 ID: 36412
		Hgene	Tgene
	Gene symbol	HIPK2	PARP12
	Gene ID	28996	64761
	Gene name	homeodomain interacting protein kinase 2	poly(ADP-ribose) polymerase family member 12
	Synonyms	PRO0593	ARTD12\|MST109\|MSTP109\|ZC3H1\|ZC3HDC1
	Cytomap	7q34	7q34
	Type of gene	protein-coding	protein-coding
	Description	homeodomain-interacting protein kinase 2hHIPk2	protein mono-ADP-ribosyltransferase PARP12ADP-ribosyltransferase diphtheria toxin-like 12poly [ADP-ribose] polymerase 12zinc finger CCCH type domain containing 1
	Modification date	20200313	20200313
	UniProtAcc	Q9H2X6	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000342645, ENST00000406875, ENST00000428878,	ENST00000470515, ENST00000263549,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	17 X 13 X 12=2652	4 X 7 X 3=84
	# samples	25	6
	** MAII score	log2(25/2652*10)=-3.4070807754505 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/84*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: HIPK2 [Title/Abstract] AND PARP12 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	HIPK2(139415731)-PARP12(139726148), # samples:3
Anticipated loss of major functional domain due to fusion event.	HIPK2-PARP12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HIPK2-PARP12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HIPK2-PARP12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. HIPK2-PARP12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. HIPK2-PARP12 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. HIPK2-PARP12 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. HIPK2-PARP12 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HIPK2	GO:0006468	protein phosphorylation	19448668
Hgene	HIPK2	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	14647468
Hgene	HIPK2	GO:0045766	positive regulation of angiogenesis	19046997
Hgene	HIPK2	GO:0060395	SMAD protein signal transduction	12874272
Tgene	PARP12	GO:0070213	protein auto-ADP-ribosylation	25043379

Fusion gene breakpoints across HIPK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PARP12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCEC	TCGA-A5-A2K4-01A	HIPK2	chr7	139415730	-	PARP12	chr7	139726147	-
ChimerDB4	UCEC	TCGA-A5-A2K4-01A	HIPK2	chr7	139415730	-	PARP12	chr7	139728487	-
ChimerDB4	UCEC	TCGA-A5-A2K4-01A	HIPK2	chr7	139415731	-	PARP12	chr7	139726148	-
ChimerDB4	UCEC	TCGA-A5-A2K4	HIPK2	chr7	139415730	-	PARP12	chr7	139726148	-
ChimerDB4	UCEC	TCGA-KP-A3W4-01A	HIPK2	chr7	139415730	-	PARP12	chr7	139726147	-
ChimerDB4	UCEC	TCGA-KP-A3W4-01A	HIPK2	chr7	139415730	-	PARP12	chr7	139728487	-
ChimerDB4	UCEC	TCGA-KP-A3W4-01A	HIPK2	chr7	139415731	-	PARP12	chr7	139726148	-
ChimerDB4	UCEC	TCGA-KP-A3W4-01A	HIPK2	chr7	139415731	-	PARP12	chr7	139727206	-
ChimerDB4	UCEC	TCGA-KP-A3W4-01A	HIPK2	chr7	139415731	-	PARP12	chr7	139728488	-
ChimerDB4	UCEC	TCGA-KP-A3W4	HIPK2	chr7	139415730	-	PARP12	chr7	139726148	-
ChimerDB4	UCEC	TCGA-KP-A3W4	HIPK2	chr7	139415730	-	PARP12	chr7	139727206	-
ChimerDB4	UCEC	TCGA-KP-A3W4	HIPK2	chr7	139415730	-	PARP12	chr7	139728488	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000406875	HIPK2	chr7	139415730	-	ENST00000263549	PARP12	chr7	139728488	-	2699	1198	95	1882	595
ENST00000428878	HIPK2	chr7	139415730	-	ENST00000263549	PARP12	chr7	139728488	-	2759	1258	155	1942	595
ENST00000342645	HIPK2	chr7	139415730	-	ENST00000263549	PARP12	chr7	139728488	-	2604	1103	21	1787	588
ENST00000406875	HIPK2	chr7	139415730	-	ENST00000263549	PARP12	chr7	139726148	-	2492	1198	95	1675	526
ENST00000428878	HIPK2	chr7	139415730	-	ENST00000263549	PARP12	chr7	139726148	-	2552	1258	155	1735	526
ENST00000342645	HIPK2	chr7	139415730	-	ENST00000263549	PARP12	chr7	139726148	-	2397	1103	21	1580	519
ENST00000406875	HIPK2	chr7	139415731	-	ENST00000263549	PARP12	chr7	139726148	-	2492	1198	95	1675	526
ENST00000428878	HIPK2	chr7	139415731	-	ENST00000263549	PARP12	chr7	139726148	-	2552	1258	155	1735	526
ENST00000342645	HIPK2	chr7	139415731	-	ENST00000263549	PARP12	chr7	139726148	-	2397	1103	21	1580	519
ENST00000406875	HIPK2	chr7	139415731	-	ENST00000263549	PARP12	chr7	139728488	-	2699	1198	95	1882	595
ENST00000428878	HIPK2	chr7	139415731	-	ENST00000263549	PARP12	chr7	139728488	-	2759	1258	155	1942	595
ENST00000342645	HIPK2	chr7	139415731	-	ENST00000263549	PARP12	chr7	139728488	-	2604	1103	21	1787	588
ENST00000406875	HIPK2	chr7	139415730	-	ENST00000263549	PARP12	chr7	139726147	-	2492	1198	95	1675	526
ENST00000428878	HIPK2	chr7	139415730	-	ENST00000263549	PARP12	chr7	139726147	-	2552	1258	155	1735	526
ENST00000342645	HIPK2	chr7	139415730	-	ENST00000263549	PARP12	chr7	139726147	-	2397	1103	21	1580	519
ENST00000406875	HIPK2	chr7	139415730	-	ENST00000263549	PARP12	chr7	139728487	-	2699	1198	95	1882	595
ENST00000428878	HIPK2	chr7	139415730	-	ENST00000263549	PARP12	chr7	139728487	-	2759	1258	155	1942	595
ENST00000342645	HIPK2	chr7	139415730	-	ENST00000263549	PARP12	chr7	139728487	-	2604	1103	21	1787	588

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000406875	ENST00000263549	HIPK2	chr7	139415730	-	PARP12	chr7	139728488	-	0.004478569	0.9955214
ENST00000428878	ENST00000263549	HIPK2	chr7	139415730	-	PARP12	chr7	139728488	-	0.004635077	0.9953649
ENST00000342645	ENST00000263549	HIPK2	chr7	139415730	-	PARP12	chr7	139728488	-	0.003802799	0.9961972
ENST00000406875	ENST00000263549	HIPK2	chr7	139415730	-	PARP12	chr7	139726148	-	0.003501919	0.9964981
ENST00000428878	ENST00000263549	HIPK2	chr7	139415730	-	PARP12	chr7	139726148	-	0.003737041	0.99626297
ENST00000342645	ENST00000263549	HIPK2	chr7	139415730	-	PARP12	chr7	139726148	-	0.002572118	0.9974279
ENST00000406875	ENST00000263549	HIPK2	chr7	139415731	-	PARP12	chr7	139726148	-	0.003501919	0.9964981
ENST00000428878	ENST00000263549	HIPK2	chr7	139415731	-	PARP12	chr7	139726148	-	0.003737041	0.99626297
ENST00000342645	ENST00000263549	HIPK2	chr7	139415731	-	PARP12	chr7	139726148	-	0.002572118	0.9974279
ENST00000406875	ENST00000263549	HIPK2	chr7	139415731	-	PARP12	chr7	139728488	-	0.004478569	0.9955214
ENST00000428878	ENST00000263549	HIPK2	chr7	139415731	-	PARP12	chr7	139728488	-	0.004635077	0.9953649
ENST00000342645	ENST00000263549	HIPK2	chr7	139415731	-	PARP12	chr7	139728488	-	0.003802799	0.9961972
ENST00000406875	ENST00000263549	HIPK2	chr7	139415730	-	PARP12	chr7	139726147	-	0.003501919	0.9964981
ENST00000428878	ENST00000263549	HIPK2	chr7	139415730	-	PARP12	chr7	139726147	-	0.003737041	0.99626297
ENST00000342645	ENST00000263549	HIPK2	chr7	139415730	-	PARP12	chr7	139726147	-	0.002572118	0.9974279
ENST00000406875	ENST00000263549	HIPK2	chr7	139415730	-	PARP12	chr7	139728487	-	0.004478569	0.9955214
ENST00000428878	ENST00000263549	HIPK2	chr7	139415730	-	PARP12	chr7	139728487	-	0.004635077	0.9953649
ENST00000342645	ENST00000263549	HIPK2	chr7	139415730	-	PARP12	chr7	139728487	-	0.003802799	0.9961972

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>36412_36412_1_HIPK2-PARP12_HIPK2_chr7_139415730_ENST00000342645_PARP12_chr7_139726147_ENST00000263549_length(amino acids)=519AA_BP=360
MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTS
ASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDYQLV
QHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVF
EMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY
RQKGQMQKQNGGKAVDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARDAAYSHHYSKSDTQTHTMFLARVLVGEFVRGNA

--------------------------------------------------------------

>36412_36412_2_HIPK2-PARP12_HIPK2_chr7_139415730_ENST00000342645_PARP12_chr7_139726148_ENST00000263549_length(amino acids)=519AA_BP=360
MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTS
ASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDYQLV
QHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVF
EMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY
RQKGQMQKQNGGKAVDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARDAAYSHHYSKSDTQTHTMFLARVLVGEFVRGNA

--------------------------------------------------------------

>36412_36412_3_HIPK2-PARP12_HIPK2_chr7_139415730_ENST00000342645_PARP12_chr7_139728487_ENST00000263549_length(amino acids)=588AA_BP=360
MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTS
ASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDYQLV
QHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVF
EMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY
SNTKFPGPKSIPDYWDSSALPDPGFQKITLSSSSEEYQKVWNLFNRTLPFYFVQKIERVQNLALWEVYQWQKGQMQKQNGGKAVDERQLF
HGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARDAAYSHHYSKSDTQTHTMFLARVLVGEFVRGNASFVRPPAKEGWSNAFYDSCVN

--------------------------------------------------------------

>36412_36412_4_HIPK2-PARP12_HIPK2_chr7_139415730_ENST00000342645_PARP12_chr7_139728488_ENST00000263549_length(amino acids)=588AA_BP=360
MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTS
ASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDYQLV
QHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVF
EMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY
SNTKFPGPKSIPDYWDSSALPDPGFQKITLSSSSEEYQKVWNLFNRTLPFYFVQKIERVQNLALWEVYQWQKGQMQKQNGGKAVDERQLF
HGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARDAAYSHHYSKSDTQTHTMFLARVLVGEFVRGNASFVRPPAKEGWSNAFYDSCVN

--------------------------------------------------------------

>36412_36412_5_HIPK2-PARP12_HIPK2_chr7_139415730_ENST00000406875_PARP12_chr7_139726147_ENST00000263549_length(amino acids)=526AA_BP=367
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGST
GHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHK
NHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
YLQSRYYRQKGQMQKQNGGKAVDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARDAAYSHHYSKSDTQTHTMFLARVLVG

--------------------------------------------------------------

>36412_36412_6_HIPK2-PARP12_HIPK2_chr7_139415730_ENST00000406875_PARP12_chr7_139726148_ENST00000263549_length(amino acids)=526AA_BP=367
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGST
GHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHK
NHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
YLQSRYYRQKGQMQKQNGGKAVDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARDAAYSHHYSKSDTQTHTMFLARVLVG

--------------------------------------------------------------

>36412_36412_7_HIPK2-PARP12_HIPK2_chr7_139415730_ENST00000406875_PARP12_chr7_139728487_ENST00000263549_length(amino acids)=595AA_BP=367
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGST
GHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHK
NHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
YLQSRYYSNTKFPGPKSIPDYWDSSALPDPGFQKITLSSSSEEYQKVWNLFNRTLPFYFVQKIERVQNLALWEVYQWQKGQMQKQNGGKA
VDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARDAAYSHHYSKSDTQTHTMFLARVLVGEFVRGNASFVRPPAKEGWSNA

--------------------------------------------------------------

>36412_36412_8_HIPK2-PARP12_HIPK2_chr7_139415730_ENST00000406875_PARP12_chr7_139728488_ENST00000263549_length(amino acids)=595AA_BP=367
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGST
GHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHK
NHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
YLQSRYYSNTKFPGPKSIPDYWDSSALPDPGFQKITLSSSSEEYQKVWNLFNRTLPFYFVQKIERVQNLALWEVYQWQKGQMQKQNGGKA
VDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARDAAYSHHYSKSDTQTHTMFLARVLVGEFVRGNASFVRPPAKEGWSNA

--------------------------------------------------------------

>36412_36412_9_HIPK2-PARP12_HIPK2_chr7_139415730_ENST00000428878_PARP12_chr7_139726147_ENST00000263549_length(amino acids)=526AA_BP=367
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGST
GHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHK
NHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
YLQSRYYRQKGQMQKQNGGKAVDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARDAAYSHHYSKSDTQTHTMFLARVLVG

--------------------------------------------------------------

>36412_36412_10_HIPK2-PARP12_HIPK2_chr7_139415730_ENST00000428878_PARP12_chr7_139726148_ENST00000263549_length(amino acids)=526AA_BP=367
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGST
GHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHK
NHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
YLQSRYYRQKGQMQKQNGGKAVDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARDAAYSHHYSKSDTQTHTMFLARVLVG

--------------------------------------------------------------

>36412_36412_11_HIPK2-PARP12_HIPK2_chr7_139415730_ENST00000428878_PARP12_chr7_139728487_ENST00000263549_length(amino acids)=595AA_BP=367
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGST
GHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHK
NHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
YLQSRYYSNTKFPGPKSIPDYWDSSALPDPGFQKITLSSSSEEYQKVWNLFNRTLPFYFVQKIERVQNLALWEVYQWQKGQMQKQNGGKA
VDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARDAAYSHHYSKSDTQTHTMFLARVLVGEFVRGNASFVRPPAKEGWSNA

--------------------------------------------------------------

>36412_36412_12_HIPK2-PARP12_HIPK2_chr7_139415730_ENST00000428878_PARP12_chr7_139728488_ENST00000263549_length(amino acids)=595AA_BP=367
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGST
GHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHK
NHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
YLQSRYYSNTKFPGPKSIPDYWDSSALPDPGFQKITLSSSSEEYQKVWNLFNRTLPFYFVQKIERVQNLALWEVYQWQKGQMQKQNGGKA
VDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARDAAYSHHYSKSDTQTHTMFLARVLVGEFVRGNASFVRPPAKEGWSNA

--------------------------------------------------------------

>36412_36412_13_HIPK2-PARP12_HIPK2_chr7_139415731_ENST00000342645_PARP12_chr7_139726148_ENST00000263549_length(amino acids)=519AA_BP=360
MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTS
ASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDYQLV
QHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVF
EMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY
RQKGQMQKQNGGKAVDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARDAAYSHHYSKSDTQTHTMFLARVLVGEFVRGNA

--------------------------------------------------------------

>36412_36412_14_HIPK2-PARP12_HIPK2_chr7_139415731_ENST00000342645_PARP12_chr7_139728488_ENST00000263549_length(amino acids)=588AA_BP=360
MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTS
ASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDYQLV
QHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVF
EMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY
SNTKFPGPKSIPDYWDSSALPDPGFQKITLSSSSEEYQKVWNLFNRTLPFYFVQKIERVQNLALWEVYQWQKGQMQKQNGGKAVDERQLF
HGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARDAAYSHHYSKSDTQTHTMFLARVLVGEFVRGNASFVRPPAKEGWSNAFYDSCVN

--------------------------------------------------------------

>36412_36412_15_HIPK2-PARP12_HIPK2_chr7_139415731_ENST00000406875_PARP12_chr7_139726148_ENST00000263549_length(amino acids)=526AA_BP=367
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGST
GHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHK
NHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
YLQSRYYRQKGQMQKQNGGKAVDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARDAAYSHHYSKSDTQTHTMFLARVLVG

--------------------------------------------------------------

>36412_36412_16_HIPK2-PARP12_HIPK2_chr7_139415731_ENST00000406875_PARP12_chr7_139728488_ENST00000263549_length(amino acids)=595AA_BP=367
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGST
GHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHK
NHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
YLQSRYYSNTKFPGPKSIPDYWDSSALPDPGFQKITLSSSSEEYQKVWNLFNRTLPFYFVQKIERVQNLALWEVYQWQKGQMQKQNGGKA
VDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARDAAYSHHYSKSDTQTHTMFLARVLVGEFVRGNASFVRPPAKEGWSNA

--------------------------------------------------------------

>36412_36412_17_HIPK2-PARP12_HIPK2_chr7_139415731_ENST00000428878_PARP12_chr7_139726148_ENST00000263549_length(amino acids)=526AA_BP=367
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGST
GHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHK
NHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
YLQSRYYRQKGQMQKQNGGKAVDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARDAAYSHHYSKSDTQTHTMFLARVLVG

--------------------------------------------------------------

>36412_36412_18_HIPK2-PARP12_HIPK2_chr7_139415731_ENST00000428878_PARP12_chr7_139728488_ENST00000263549_length(amino acids)=595AA_BP=367
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGST
GHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHK
NHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
YLQSRYYSNTKFPGPKSIPDYWDSSALPDPGFQKITLSSSSEEYQKVWNLFNRTLPFYFVQKIERVQNLALWEVYQWQKGQMQKQNGGKA
VDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARDAAYSHHYSKSDTQTHTMFLARVLVGEFVRGNASFVRPPAKEGWSNA

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:139415731/chr7:139726148)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HIPK2 Q9H2X6	.
FUNCTION: Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. {ECO:0000269\|PubMed:11740489, ECO:0000269\|PubMed:11925430, ECO:0000269\|PubMed:12851404, ECO:0000269\|PubMed:12874272, ECO:0000269\|PubMed:14678985, ECO:0000269\|PubMed:17018294, ECO:0000269\|PubMed:17960875, ECO:0000269\|PubMed:18695000, ECO:0000269\|PubMed:18809579, ECO:0000269\|PubMed:19015637, ECO:0000269\|PubMed:19046997, ECO:0000269\|PubMed:19448668, ECO:0000269\|PubMed:20307497, ECO:0000269\|PubMed:20573984, ECO:0000269\|PubMed:20637728, ECO:0000269\|PubMed:20980392, ECO:0000269\|PubMed:21192925, ECO:0000269\|PubMed:22825850}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HIPK2

chr7:139415730

chr7:139726147

ENST00000406875

205_213

367.6666666666667

1199.0

Nucleotide binding

ATP

Hgene

HIPK2

chr7:139415730

chr7:139726147

ENST00000428878

205_213

367.6666666666667

1172.0

Nucleotide binding

ATP

Hgene

HIPK2

chr7:139415730

chr7:139726148

ENST00000406875

205_213

367.6666666666667

1199.0

Nucleotide binding

ATP

Hgene

HIPK2

chr7:139415730

chr7:139726148

ENST00000428878

205_213

367.6666666666667

1172.0

Nucleotide binding

ATP

Hgene

HIPK2

chr7:139415730

chr7:139728487

ENST00000406875

205_213

367.6666666666667

1199.0

Nucleotide binding

ATP

Hgene

HIPK2

chr7:139415730

chr7:139728487

ENST00000428878

205_213

367.6666666666667

1172.0

Nucleotide binding

ATP

Hgene

HIPK2

chr7:139415730

chr7:139728488

ENST00000406875

205_213

367.6666666666667

1199.0

Nucleotide binding

ATP

Hgene

HIPK2

chr7:139415730

chr7:139728488

ENST00000428878

205_213

367.6666666666667

1172.0

Nucleotide binding

ATP

Hgene

HIPK2

chr7:139415731

chr7:139726148

ENST00000406875

205_213

367.6666666666667

1199.0

Nucleotide binding

ATP

Hgene

HIPK2

chr7:139415731

chr7:139726148

ENST00000428878

205_213

367.6666666666667

1172.0

Nucleotide binding

ATP

Hgene

HIPK2

chr7:139415731

chr7:139728488

ENST00000406875

205_213

367.6666666666667

1199.0

Nucleotide binding

ATP

Hgene

HIPK2

chr7:139415731

chr7:139728488

ENST00000428878

205_213

367.6666666666667

1172.0

Nucleotide binding

ATP

Hgene

HIPK2

chr7:139415730

chr7:139726147

ENST00000406875

97_230

367.6666666666667

1199.0

Region

Transcriptional corepression

Hgene

HIPK2

chr7:139415730

chr7:139726147

ENST00000428878

97_230

367.6666666666667

1172.0

Region

Transcriptional corepression

Hgene

HIPK2

chr7:139415730

chr7:139726148

ENST00000406875

97_230

367.6666666666667

1199.0

Region

Transcriptional corepression

Hgene

HIPK2

chr7:139415730

chr7:139726148

ENST00000428878

97_230

367.6666666666667

1172.0

Region

Transcriptional corepression

Hgene

HIPK2

chr7:139415730

chr7:139728487

ENST00000406875

97_230

367.6666666666667

1199.0

Region

Transcriptional corepression

Hgene

HIPK2

chr7:139415730

chr7:139728487

ENST00000428878

97_230

367.6666666666667

1172.0

Region

Transcriptional corepression

Hgene

HIPK2

chr7:139415730

chr7:139728488

ENST00000406875

97_230

367.6666666666667

1199.0

Region

Transcriptional corepression

Hgene

HIPK2

chr7:139415730

chr7:139728488

ENST00000428878

97_230

367.6666666666667

1172.0

Region

Transcriptional corepression

Hgene

HIPK2

chr7:139415731

chr7:139726148

ENST00000406875

97_230

367.6666666666667

1199.0

Region

Transcriptional corepression

Hgene

HIPK2

chr7:139415731

chr7:139726148

ENST00000428878

97_230

367.6666666666667

1172.0

Region

Transcriptional corepression

Hgene

HIPK2

chr7:139415731

chr7:139728488

ENST00000406875

97_230

367.6666666666667

1199.0

Region

Transcriptional corepression

Hgene

HIPK2

chr7:139415731

chr7:139728488

ENST00000428878

97_230

367.6666666666667

1172.0

Region

Transcriptional corepression

Tgene

PARP12

chr7:139415730

chr7:139728487

ENST00000263549

484_698

473.6666666666667

702.0

Domain

PARP catalytic

Tgene

PARP12

chr7:139415730

chr7:139728488

ENST00000263549

484_698

473.6666666666667

702.0

Domain

PARP catalytic

Tgene

PARP12

chr7:139415731

chr7:139728488

ENST00000263549

484_698

473.6666666666667

702.0

Domain

PARP catalytic

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HIPK2

chr7:139415730

chr7:139726147

ENST00000406875

1088_1094

367.6666666666667

1199.0

Compositional bias

Note=Poly-Ala

Hgene

HIPK2

chr7:139415730

chr7:139726147

ENST00000428878

1088_1094

367.6666666666667

1172.0

Compositional bias

Note=Poly-Ala

Hgene

HIPK2

chr7:139415730

chr7:139726148

ENST00000406875

1088_1094

367.6666666666667

1199.0

Compositional bias

Note=Poly-Ala

Hgene

HIPK2

chr7:139415730

chr7:139726148

ENST00000428878

1088_1094

367.6666666666667

1172.0

Compositional bias

Note=Poly-Ala

Hgene

HIPK2

chr7:139415730

chr7:139728487

ENST00000406875

1088_1094

367.6666666666667

1199.0

Compositional bias

Note=Poly-Ala

Hgene

HIPK2

chr7:139415730

chr7:139728487

ENST00000428878

1088_1094

367.6666666666667

1172.0

Compositional bias

Note=Poly-Ala

Hgene

HIPK2

chr7:139415730

chr7:139728488

ENST00000406875

1088_1094

367.6666666666667

1199.0

Compositional bias

Note=Poly-Ala

Hgene

HIPK2

chr7:139415730

chr7:139728488

ENST00000428878

1088_1094

367.6666666666667

1172.0

Compositional bias

Note=Poly-Ala

Hgene

HIPK2

chr7:139415731

chr7:139726148

ENST00000406875

1088_1094

367.6666666666667

1199.0

Compositional bias

Note=Poly-Ala

Hgene

HIPK2

chr7:139415731

chr7:139726148

ENST00000428878

1088_1094

367.6666666666667

1172.0

Compositional bias

Note=Poly-Ala

Hgene

HIPK2

chr7:139415731

chr7:139728488

ENST00000406875

1088_1094

367.6666666666667

1199.0

Compositional bias

Note=Poly-Ala

Hgene

HIPK2

chr7:139415731

chr7:139728488

ENST00000428878

1088_1094

367.6666666666667

1172.0

Compositional bias

Note=Poly-Ala

Hgene

HIPK2

chr7:139415730

chr7:139726147

ENST00000406875

199_527

367.6666666666667

1199.0

Domain

Protein kinase

Hgene

HIPK2

chr7:139415730

chr7:139726147

ENST00000428878

199_527

367.6666666666667

1172.0

Domain

Protein kinase

Hgene

HIPK2

chr7:139415730

chr7:139726148

ENST00000406875

199_527

367.6666666666667

1199.0

Domain

Protein kinase

Hgene

HIPK2

chr7:139415730

chr7:139726148

ENST00000428878

199_527

367.6666666666667

1172.0

Domain

Protein kinase

Hgene

HIPK2

chr7:139415730

chr7:139728487

ENST00000406875

199_527

367.6666666666667

1199.0

Domain

Protein kinase

Hgene

HIPK2

chr7:139415730

chr7:139728487

ENST00000428878

199_527

367.6666666666667

1172.0

Domain

Protein kinase

Hgene

HIPK2

chr7:139415730

chr7:139728488

ENST00000406875

199_527

367.6666666666667

1199.0

Domain

Protein kinase

Hgene

HIPK2

chr7:139415730

chr7:139728488

ENST00000428878

199_527

367.6666666666667

1172.0

Domain

Protein kinase

Hgene

HIPK2

chr7:139415731

chr7:139726148

ENST00000406875

199_527

367.6666666666667

1199.0

Domain

Protein kinase

Hgene

HIPK2

chr7:139415731

chr7:139726148

ENST00000428878

199_527

367.6666666666667

1172.0

Domain

Protein kinase

Hgene

HIPK2

chr7:139415731

chr7:139728488

ENST00000406875

199_527

367.6666666666667

1199.0

Domain

Protein kinase

Hgene

HIPK2

chr7:139415731

chr7:139728488

ENST00000428878

199_527

367.6666666666667

1172.0

Domain

Protein kinase

Hgene

HIPK2

chr7:139415730

chr7:139726147

ENST00000406875

802_805

367.6666666666667

1199.0

Motif

Note=Nuclear localization signal 1 (NLS1)

Hgene

HIPK2

chr7:139415730

chr7:139726147

ENST00000406875

832_835

367.6666666666667

1199.0

Motif

Note=Nuclear localization signal 2 (NLS2)

Hgene

HIPK2

chr7:139415730

chr7:139726147

ENST00000428878

802_805

367.6666666666667

1172.0

Motif

Note=Nuclear localization signal 1 (NLS1)

Hgene

HIPK2

chr7:139415730

chr7:139726147

ENST00000428878

832_835

367.6666666666667

1172.0

Motif

Note=Nuclear localization signal 2 (NLS2)

Hgene

HIPK2

chr7:139415730

chr7:139726148

ENST00000406875

802_805

367.6666666666667

1199.0

Motif

Note=Nuclear localization signal 1 (NLS1)

Hgene

HIPK2

chr7:139415730

chr7:139726148

ENST00000406875

832_835

367.6666666666667

1199.0

Motif

Note=Nuclear localization signal 2 (NLS2)

Hgene

HIPK2

chr7:139415730

chr7:139726148

ENST00000428878

802_805

367.6666666666667

1172.0

Motif

Note=Nuclear localization signal 1 (NLS1)

Hgene

HIPK2

chr7:139415730

chr7:139726148

ENST00000428878

832_835

367.6666666666667

1172.0

Motif

Note=Nuclear localization signal 2 (NLS2)

Hgene

HIPK2

chr7:139415730

chr7:139728487

ENST00000406875

802_805

367.6666666666667

1199.0

Motif

Note=Nuclear localization signal 1 (NLS1)

Hgene

HIPK2

chr7:139415730

chr7:139728487

ENST00000406875

832_835

367.6666666666667

1199.0

Motif

Note=Nuclear localization signal 2 (NLS2)

Hgene

HIPK2

chr7:139415730

chr7:139728487

ENST00000428878

802_805

367.6666666666667

1172.0

Motif

Note=Nuclear localization signal 1 (NLS1)

Hgene

HIPK2

chr7:139415730

chr7:139728487

ENST00000428878

832_835

367.6666666666667

1172.0

Motif

Note=Nuclear localization signal 2 (NLS2)

Hgene

HIPK2

chr7:139415730

chr7:139728488

ENST00000406875

802_805

367.6666666666667

1199.0

Motif

Note=Nuclear localization signal 1 (NLS1)

Hgene

HIPK2

chr7:139415730

chr7:139728488

ENST00000406875

832_835

367.6666666666667

1199.0

Motif

Note=Nuclear localization signal 2 (NLS2)

Hgene

HIPK2

chr7:139415730

chr7:139728488

ENST00000428878

802_805

367.6666666666667

1172.0

Motif

Note=Nuclear localization signal 1 (NLS1)

Hgene

HIPK2

chr7:139415730

chr7:139728488

ENST00000428878

832_835

367.6666666666667

1172.0

Motif

Note=Nuclear localization signal 2 (NLS2)

Hgene

HIPK2

chr7:139415731

chr7:139726148

ENST00000406875

802_805

367.6666666666667

1199.0

Motif

Note=Nuclear localization signal 1 (NLS1)

Hgene

HIPK2

chr7:139415731

chr7:139726148

ENST00000406875

832_835

367.6666666666667

1199.0

Motif

Note=Nuclear localization signal 2 (NLS2)

Hgene

HIPK2

chr7:139415731

chr7:139726148

ENST00000428878

802_805

367.6666666666667

1172.0

Motif

Note=Nuclear localization signal 1 (NLS1)

Hgene

HIPK2

chr7:139415731

chr7:139726148

ENST00000428878

832_835

367.6666666666667

1172.0

Motif

Note=Nuclear localization signal 2 (NLS2)

Hgene

HIPK2

chr7:139415731

chr7:139728488

ENST00000406875

802_805

367.6666666666667

1199.0

Motif

Note=Nuclear localization signal 1 (NLS1)

Hgene

HIPK2

chr7:139415731

chr7:139728488

ENST00000406875

832_835

367.6666666666667

1199.0

Motif

Note=Nuclear localization signal 2 (NLS2)

Hgene

HIPK2

chr7:139415731

chr7:139728488

ENST00000428878

802_805

367.6666666666667

1172.0

Motif

Note=Nuclear localization signal 1 (NLS1)

Hgene

HIPK2

chr7:139415731

chr7:139728488

ENST00000428878

832_835

367.6666666666667

1172.0

Motif

Note=Nuclear localization signal 2 (NLS2)

Hgene

HIPK2

chr7:139415730

chr7:139726147

ENST00000406875

873_980

367.6666666666667

1199.0

Region

Required for localization to nuclear speckles

Hgene

HIPK2

chr7:139415730

chr7:139726147

ENST00000406875

984_1198

367.6666666666667

1199.0

Region

Note=Autoinhibitory domain (AID)

Hgene

HIPK2

chr7:139415730

chr7:139726147

ENST00000428878

873_980

367.6666666666667

1172.0

Region

Required for localization to nuclear speckles

Hgene

HIPK2

chr7:139415730

chr7:139726147

ENST00000428878

984_1198

367.6666666666667

1172.0

Region

Note=Autoinhibitory domain (AID)

Hgene

HIPK2

chr7:139415730

chr7:139726148

ENST00000406875

873_980

367.6666666666667

1199.0

Region

Required for localization to nuclear speckles

Hgene

HIPK2

chr7:139415730

chr7:139726148

ENST00000406875

984_1198

367.6666666666667

1199.0

Region

Note=Autoinhibitory domain (AID)

Hgene

HIPK2

chr7:139415730

chr7:139726148

ENST00000428878

873_980

367.6666666666667

1172.0

Region

Required for localization to nuclear speckles

Hgene

HIPK2

chr7:139415730

chr7:139726148

ENST00000428878

984_1198

367.6666666666667

1172.0

Region

Note=Autoinhibitory domain (AID)

Hgene

HIPK2

chr7:139415730

chr7:139728487

ENST00000406875

873_980

367.6666666666667

1199.0

Region

Required for localization to nuclear speckles

Hgene

HIPK2

chr7:139415730

chr7:139728487

ENST00000406875

984_1198

367.6666666666667

1199.0

Region

Note=Autoinhibitory domain (AID)

Hgene

HIPK2

chr7:139415730

chr7:139728487

ENST00000428878

873_980

367.6666666666667

1172.0

Region

Required for localization to nuclear speckles

Hgene

HIPK2

chr7:139415730

chr7:139728487

ENST00000428878

984_1198

367.6666666666667

1172.0

Region

Note=Autoinhibitory domain (AID)

Hgene

HIPK2

chr7:139415730

chr7:139728488

ENST00000406875

873_980

367.6666666666667

1199.0

Region

Required for localization to nuclear speckles

Hgene

HIPK2

chr7:139415730

chr7:139728488

ENST00000406875

984_1198

367.6666666666667

1199.0

Region

Note=Autoinhibitory domain (AID)

Hgene

HIPK2

chr7:139415730

chr7:139728488

ENST00000428878

873_980

367.6666666666667

1172.0

Region

Required for localization to nuclear speckles

Hgene

HIPK2

chr7:139415730

chr7:139728488

ENST00000428878

984_1198

367.6666666666667

1172.0

Region

Note=Autoinhibitory domain (AID)

Hgene

HIPK2

chr7:139415731

chr7:139726148

ENST00000406875

873_980

367.6666666666667

1199.0

Region

Required for localization to nuclear speckles

Hgene

HIPK2

chr7:139415731

chr7:139726148

ENST00000406875

984_1198

367.6666666666667

1199.0

Region

Note=Autoinhibitory domain (AID)

Hgene

HIPK2

chr7:139415731

chr7:139726148

ENST00000428878

873_980

367.6666666666667

1172.0

Region

Required for localization to nuclear speckles

Hgene

HIPK2

chr7:139415731

chr7:139726148

ENST00000428878

984_1198

367.6666666666667

1172.0

Region

Note=Autoinhibitory domain (AID)

Hgene

HIPK2

chr7:139415731

chr7:139728488

ENST00000406875

873_980

367.6666666666667

1199.0

Region

Required for localization to nuclear speckles

Hgene

HIPK2

chr7:139415731

chr7:139728488

ENST00000406875

984_1198

367.6666666666667

1199.0

Region

Note=Autoinhibitory domain (AID)

Hgene

HIPK2

chr7:139415731

chr7:139728488

ENST00000428878

873_980

367.6666666666667

1172.0

Region

Required for localization to nuclear speckles

Hgene

HIPK2

chr7:139415731

chr7:139728488

ENST00000428878

984_1198

367.6666666666667

1172.0

Region

Note=Autoinhibitory domain (AID)

Tgene

PARP12

chr7:139415730

chr7:139726147

ENST00000263549

58_61

542.6666666666666

702.0

Compositional bias

Note=Poly-Ala

Tgene

PARP12

chr7:139415730

chr7:139726148

ENST00000263549

58_61

542.6666666666666

702.0

Compositional bias

Note=Poly-Ala

Tgene

PARP12

chr7:139415730

chr7:139728487

ENST00000263549

58_61

473.6666666666667

702.0

Compositional bias

Note=Poly-Ala

Tgene

PARP12

chr7:139415730

chr7:139728488

ENST00000263549

58_61

473.6666666666667

702.0

Compositional bias

Note=Poly-Ala

Tgene

PARP12

chr7:139415731

chr7:139726148

ENST00000263549

58_61

542.6666666666666

702.0

Compositional bias

Note=Poly-Ala

Tgene

PARP12

chr7:139415731

chr7:139728488

ENST00000263549

58_61

473.6666666666667

702.0

Compositional bias

Note=Poly-Ala

Tgene

PARP12

chr7:139415730

chr7:139726147

ENST00000263549

298_361

542.6666666666666

702.0

Domain

WWE 1

Tgene

PARP12

chr7:139415730

chr7:139726147

ENST00000263549

364_458

542.6666666666666

702.0

Domain

WWE 2

Tgene

PARP12

chr7:139415730

chr7:139726147

ENST00000263549

484_698

542.6666666666666

702.0

Domain

PARP catalytic

Tgene

PARP12

chr7:139415730

chr7:139726148

ENST00000263549

298_361

542.6666666666666

702.0

Domain

WWE 1

Tgene

PARP12

chr7:139415730

chr7:139726148

ENST00000263549

364_458

542.6666666666666

702.0

Domain

WWE 2

Tgene

PARP12

chr7:139415730

chr7:139726148

ENST00000263549

484_698

542.6666666666666

702.0

Domain

PARP catalytic

Tgene

PARP12

chr7:139415730

chr7:139728487

ENST00000263549

298_361

473.6666666666667

702.0

Domain

WWE 1

Tgene

PARP12

chr7:139415730

chr7:139728487

ENST00000263549

364_458

473.6666666666667

702.0

Domain

WWE 2

Tgene

PARP12

chr7:139415730

chr7:139728488

ENST00000263549

298_361

473.6666666666667

702.0

Domain

WWE 1

Tgene

PARP12

chr7:139415730

chr7:139728488

ENST00000263549

364_458

473.6666666666667

702.0

Domain

WWE 2

Tgene

PARP12

chr7:139415731

chr7:139726148

ENST00000263549

298_361

542.6666666666666

702.0

Domain

WWE 1

Tgene

PARP12

chr7:139415731

chr7:139726148

ENST00000263549

364_458

542.6666666666666

702.0

Domain

WWE 2

Tgene

PARP12

chr7:139415731

chr7:139726148

ENST00000263549

484_698

542.6666666666666

702.0

Domain

PARP catalytic

Tgene

PARP12

chr7:139415731

chr7:139728488

ENST00000263549

298_361

473.6666666666667

702.0

Domain

WWE 1

Tgene

PARP12

chr7:139415731

chr7:139728488

ENST00000263549

364_458

473.6666666666667

702.0

Domain

WWE 2

Tgene

PARP12

chr7:139415730

chr7:139726147

ENST00000263549

150_179

542.6666666666666

702.0

Zinc finger

C3H1-type 2

Tgene

PARP12

chr7:139415730

chr7:139726147

ENST00000263549

180_202

542.6666666666666

702.0

Zinc finger

C3H1-type 3

Tgene

PARP12

chr7:139415730

chr7:139726147

ENST00000263549

270_297

542.6666666666666

702.0

Zinc finger

C3H1-type 4

Tgene

PARP12

chr7:139415730

chr7:139726147

ENST00000263549

271_296

542.6666666666666

702.0

Zinc finger

C3H1-type 3

Tgene

PARP12

chr7:139415730

chr7:139726147

ENST00000263549

94_119

542.6666666666666

702.0

Zinc finger

C3H1-type 1

Tgene

PARP12

chr7:139415730

chr7:139726148

ENST00000263549

150_179

542.6666666666666

702.0

Zinc finger

C3H1-type 2

Tgene

PARP12

chr7:139415730

chr7:139726148

ENST00000263549

180_202

542.6666666666666

702.0

Zinc finger

C3H1-type 3

Tgene

PARP12

chr7:139415730

chr7:139726148

ENST00000263549

270_297

542.6666666666666

702.0

Zinc finger

C3H1-type 4

Tgene

PARP12

chr7:139415730

chr7:139726148

ENST00000263549

271_296

542.6666666666666

702.0

Zinc finger

C3H1-type 3

Tgene

PARP12

chr7:139415730

chr7:139726148

ENST00000263549

94_119

542.6666666666666

702.0

Zinc finger

C3H1-type 1

Tgene

PARP12

chr7:139415730

chr7:139728487

ENST00000263549

150_179

473.6666666666667

702.0

Zinc finger

C3H1-type 2

Tgene

PARP12

chr7:139415730

chr7:139728487

ENST00000263549

180_202

473.6666666666667

702.0

Zinc finger

C3H1-type 3

Tgene

PARP12

chr7:139415730

chr7:139728487

ENST00000263549

270_297

473.6666666666667

702.0

Zinc finger

C3H1-type 4

Tgene

PARP12

chr7:139415730

chr7:139728487

ENST00000263549

271_296

473.6666666666667

702.0

Zinc finger

C3H1-type 3

Tgene

PARP12

chr7:139415730

chr7:139728487

ENST00000263549

94_119

473.6666666666667

702.0

Zinc finger

C3H1-type 1

Tgene

PARP12

chr7:139415730

chr7:139728488

ENST00000263549

150_179

473.6666666666667

702.0

Zinc finger

C3H1-type 2

Tgene

PARP12

chr7:139415730

chr7:139728488

ENST00000263549

180_202

473.6666666666667

702.0

Zinc finger

C3H1-type 3

Tgene

PARP12

chr7:139415730

chr7:139728488

ENST00000263549

270_297

473.6666666666667

702.0

Zinc finger

C3H1-type 4

Tgene

PARP12

chr7:139415730

chr7:139728488

ENST00000263549

271_296

473.6666666666667

702.0

Zinc finger

C3H1-type 3

Tgene

PARP12

chr7:139415730

chr7:139728488

ENST00000263549

94_119

473.6666666666667

702.0

Zinc finger

C3H1-type 1

Tgene

PARP12

chr7:139415731

chr7:139726148

ENST00000263549

150_179

542.6666666666666

702.0

Zinc finger

C3H1-type 2

Tgene

PARP12

chr7:139415731

chr7:139726148

ENST00000263549

180_202

542.6666666666666

702.0

Zinc finger

C3H1-type 3

Tgene

PARP12

chr7:139415731

chr7:139726148

ENST00000263549

270_297

542.6666666666666

702.0

Zinc finger

C3H1-type 4

Tgene

PARP12

chr7:139415731

chr7:139726148

ENST00000263549

271_296

542.6666666666666

702.0

Zinc finger

C3H1-type 3

Tgene

PARP12

chr7:139415731

chr7:139726148

ENST00000263549

94_119

542.6666666666666

702.0

Zinc finger

C3H1-type 1

Tgene

PARP12

chr7:139415731

chr7:139728488

ENST00000263549

150_179

473.6666666666667

702.0

Zinc finger

C3H1-type 2

Tgene

PARP12

chr7:139415731

chr7:139728488

ENST00000263549

180_202

473.6666666666667

702.0

Zinc finger

C3H1-type 3

Tgene

PARP12

chr7:139415731

chr7:139728488

ENST00000263549

270_297

473.6666666666667

702.0

Zinc finger

C3H1-type 4

Tgene

PARP12

chr7:139415731

chr7:139728488

ENST00000263549

271_296

473.6666666666667

702.0

Zinc finger

C3H1-type 3

Tgene

PARP12

chr7:139415731

chr7:139728488

ENST00000263549

94_119

473.6666666666667

702.0

Zinc finger

C3H1-type 1

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1128_HIPK2_139415730_PARP12_139726148_1128_HIPK2_139415730_PARP12_139726148_ranked_0.pdb	HIPK2	139415730	139415730	ENST00000263549	PARP12	chr7	139726148	-	MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGST GHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHK NHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST YLQSRYYRQKGQMQKQNGGKAVDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARDAAYSHHYSKSDTQTHTMFLARVLVG	526

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

HIPK2_pLDDT.png

PARP12_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
HIPK2
PARP12

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	HIPK2	chr7:139415730	chr7:139726147	ENST00000406875	-	2	15	935_1049	367.6666666666667	1199.0	AXIN1
Hgene	HIPK2	chr7:139415730	chr7:139726147	ENST00000428878	-	2	15	935_1049	367.6666666666667	1172.0	AXIN1
Hgene	HIPK2	chr7:139415730	chr7:139726148	ENST00000406875	-	2	15	935_1049	367.6666666666667	1199.0	AXIN1
Hgene	HIPK2	chr7:139415730	chr7:139726148	ENST00000428878	-	2	15	935_1049	367.6666666666667	1172.0	AXIN1
Hgene	HIPK2	chr7:139415730	chr7:139728487	ENST00000406875	-	2	15	935_1049	367.6666666666667	1199.0	AXIN1
Hgene	HIPK2	chr7:139415730	chr7:139728487	ENST00000428878	-	2	15	935_1049	367.6666666666667	1172.0	AXIN1
Hgene	HIPK2	chr7:139415730	chr7:139728488	ENST00000406875	-	2	15	935_1049	367.6666666666667	1199.0	AXIN1
Hgene	HIPK2	chr7:139415730	chr7:139728488	ENST00000428878	-	2	15	935_1049	367.6666666666667	1172.0	AXIN1
Hgene	HIPK2	chr7:139415731	chr7:139726148	ENST00000406875	-	2	15	935_1049	367.6666666666667	1199.0	AXIN1
Hgene	HIPK2	chr7:139415731	chr7:139726148	ENST00000428878	-	2	15	935_1049	367.6666666666667	1172.0	AXIN1
Hgene	HIPK2	chr7:139415731	chr7:139728488	ENST00000406875	-	2	15	935_1049	367.6666666666667	1199.0	AXIN1
Hgene	HIPK2	chr7:139415731	chr7:139728488	ENST00000428878	-	2	15	935_1049	367.6666666666667	1172.0	AXIN1
Hgene	HIPK2	chr7:139415730	chr7:139726147	ENST00000406875	-	2	15	774_876	367.6666666666667	1199.0	CTBP1
Hgene	HIPK2	chr7:139415730	chr7:139726147	ENST00000428878	-	2	15	774_876	367.6666666666667	1172.0	CTBP1
Hgene	HIPK2	chr7:139415730	chr7:139726148	ENST00000406875	-	2	15	774_876	367.6666666666667	1199.0	CTBP1
Hgene	HIPK2	chr7:139415730	chr7:139726148	ENST00000428878	-	2	15	774_876	367.6666666666667	1172.0	CTBP1
Hgene	HIPK2	chr7:139415730	chr7:139728487	ENST00000406875	-	2	15	774_876	367.6666666666667	1199.0	CTBP1
Hgene	HIPK2	chr7:139415730	chr7:139728487	ENST00000428878	-	2	15	774_876	367.6666666666667	1172.0	CTBP1
Hgene	HIPK2	chr7:139415730	chr7:139728488	ENST00000406875	-	2	15	774_876	367.6666666666667	1199.0	CTBP1
Hgene	HIPK2	chr7:139415730	chr7:139728488	ENST00000428878	-	2	15	774_876	367.6666666666667	1172.0	CTBP1
Hgene	HIPK2	chr7:139415731	chr7:139726148	ENST00000406875	-	2	15	774_876	367.6666666666667	1199.0	CTBP1
Hgene	HIPK2	chr7:139415731	chr7:139726148	ENST00000428878	-	2	15	774_876	367.6666666666667	1172.0	CTBP1
Hgene	HIPK2	chr7:139415731	chr7:139728488	ENST00000406875	-	2	15	774_876	367.6666666666667	1199.0	CTBP1
Hgene	HIPK2	chr7:139415731	chr7:139728488	ENST00000428878	-	2	15	774_876	367.6666666666667	1172.0	CTBP1
Hgene	HIPK2	chr7:139415730	chr7:139726147	ENST00000406875	-	2	15	189_520	367.6666666666667	1199.0	DAXX
Hgene	HIPK2	chr7:139415730	chr7:139726147	ENST00000428878	-	2	15	189_520	367.6666666666667	1172.0	DAXX
Hgene	HIPK2	chr7:139415730	chr7:139726148	ENST00000406875	-	2	15	189_520	367.6666666666667	1199.0	DAXX
Hgene	HIPK2	chr7:139415730	chr7:139726148	ENST00000428878	-	2	15	189_520	367.6666666666667	1172.0	DAXX
Hgene	HIPK2	chr7:139415730	chr7:139728487	ENST00000406875	-	2	15	189_520	367.6666666666667	1199.0	DAXX
Hgene	HIPK2	chr7:139415730	chr7:139728487	ENST00000428878	-	2	15	189_520	367.6666666666667	1172.0	DAXX
Hgene	HIPK2	chr7:139415730	chr7:139728488	ENST00000406875	-	2	15	189_520	367.6666666666667	1199.0	DAXX
Hgene	HIPK2	chr7:139415730	chr7:139728488	ENST00000428878	-	2	15	189_520	367.6666666666667	1172.0	DAXX
Hgene	HIPK2	chr7:139415731	chr7:139726148	ENST00000406875	-	2	15	189_520	367.6666666666667	1199.0	DAXX
Hgene	HIPK2	chr7:139415731	chr7:139726148	ENST00000428878	-	2	15	189_520	367.6666666666667	1172.0	DAXX
Hgene	HIPK2	chr7:139415731	chr7:139728488	ENST00000406875	-	2	15	189_520	367.6666666666667	1199.0	DAXX
Hgene	HIPK2	chr7:139415731	chr7:139728488	ENST00000428878	-	2	15	189_520	367.6666666666667	1172.0	DAXX
Hgene	HIPK2	chr7:139415730	chr7:139726147	ENST00000406875	-	2	15	787_897	367.6666666666667	1199.0	HMGA1
Hgene	HIPK2	chr7:139415730	chr7:139726147	ENST00000428878	-	2	15	787_897	367.6666666666667	1172.0	HMGA1
Hgene	HIPK2	chr7:139415730	chr7:139726148	ENST00000406875	-	2	15	787_897	367.6666666666667	1199.0	HMGA1
Hgene	HIPK2	chr7:139415730	chr7:139726148	ENST00000428878	-	2	15	787_897	367.6666666666667	1172.0	HMGA1
Hgene	HIPK2	chr7:139415730	chr7:139728487	ENST00000406875	-	2	15	787_897	367.6666666666667	1199.0	HMGA1
Hgene	HIPK2	chr7:139415730	chr7:139728487	ENST00000428878	-	2	15	787_897	367.6666666666667	1172.0	HMGA1
Hgene	HIPK2	chr7:139415730	chr7:139728488	ENST00000406875	-	2	15	787_897	367.6666666666667	1199.0	HMGA1
Hgene	HIPK2	chr7:139415730	chr7:139728488	ENST00000428878	-	2	15	787_897	367.6666666666667	1172.0	HMGA1
Hgene	HIPK2	chr7:139415731	chr7:139726148	ENST00000406875	-	2	15	787_897	367.6666666666667	1199.0	HMGA1
Hgene	HIPK2	chr7:139415731	chr7:139726148	ENST00000428878	-	2	15	787_897	367.6666666666667	1172.0	HMGA1
Hgene	HIPK2	chr7:139415731	chr7:139728488	ENST00000406875	-	2	15	787_897	367.6666666666667	1199.0	HMGA1
Hgene	HIPK2	chr7:139415731	chr7:139728488	ENST00000428878	-	2	15	787_897	367.6666666666667	1172.0	HMGA1
Hgene	HIPK2	chr7:139415730	chr7:139726147	ENST00000406875	-	2	15	752_897	367.6666666666667	1199.0	POU4F1
Hgene	HIPK2	chr7:139415730	chr7:139726147	ENST00000428878	-	2	15	752_897	367.6666666666667	1172.0	POU4F1
Hgene	HIPK2	chr7:139415730	chr7:139726148	ENST00000406875	-	2	15	752_897	367.6666666666667	1199.0	POU4F1
Hgene	HIPK2	chr7:139415730	chr7:139726148	ENST00000428878	-	2	15	752_897	367.6666666666667	1172.0	POU4F1
Hgene	HIPK2	chr7:139415730	chr7:139728487	ENST00000406875	-	2	15	752_897	367.6666666666667	1199.0	POU4F1
Hgene	HIPK2	chr7:139415730	chr7:139728487	ENST00000428878	-	2	15	752_897	367.6666666666667	1172.0	POU4F1
Hgene	HIPK2	chr7:139415730	chr7:139728488	ENST00000406875	-	2	15	752_897	367.6666666666667	1199.0	POU4F1
Hgene	HIPK2	chr7:139415730	chr7:139728488	ENST00000428878	-	2	15	752_897	367.6666666666667	1172.0	POU4F1
Hgene	HIPK2	chr7:139415731	chr7:139726148	ENST00000406875	-	2	15	752_897	367.6666666666667	1199.0	POU4F1
Hgene	HIPK2	chr7:139415731	chr7:139726148	ENST00000428878	-	2	15	752_897	367.6666666666667	1172.0	POU4F1
Hgene	HIPK2	chr7:139415731	chr7:139728488	ENST00000406875	-	2	15	752_897	367.6666666666667	1199.0	POU4F1
Hgene	HIPK2	chr7:139415731	chr7:139728488	ENST00000428878	-	2	15	752_897	367.6666666666667	1172.0	POU4F1
Hgene	HIPK2	chr7:139415730	chr7:139726147	ENST00000406875	-	2	15	539_844	367.6666666666667	1199.0	SKI and SMAD1
Hgene	HIPK2	chr7:139415730	chr7:139726147	ENST00000428878	-	2	15	539_844	367.6666666666667	1172.0	SKI and SMAD1
Hgene	HIPK2	chr7:139415730	chr7:139726148	ENST00000406875	-	2	15	539_844	367.6666666666667	1199.0	SKI and SMAD1
Hgene	HIPK2	chr7:139415730	chr7:139726148	ENST00000428878	-	2	15	539_844	367.6666666666667	1172.0	SKI and SMAD1
Hgene	HIPK2	chr7:139415730	chr7:139728487	ENST00000406875	-	2	15	539_844	367.6666666666667	1199.0	SKI and SMAD1
Hgene	HIPK2	chr7:139415730	chr7:139728487	ENST00000428878	-	2	15	539_844	367.6666666666667	1172.0	SKI and SMAD1
Hgene	HIPK2	chr7:139415730	chr7:139728488	ENST00000406875	-	2	15	539_844	367.6666666666667	1199.0	SKI and SMAD1
Hgene	HIPK2	chr7:139415730	chr7:139728488	ENST00000428878	-	2	15	539_844	367.6666666666667	1172.0	SKI and SMAD1
Hgene	HIPK2	chr7:139415731	chr7:139726148	ENST00000406875	-	2	15	539_844	367.6666666666667	1199.0	SKI and SMAD1
Hgene	HIPK2	chr7:139415731	chr7:139726148	ENST00000428878	-	2	15	539_844	367.6666666666667	1172.0	SKI and SMAD1
Hgene	HIPK2	chr7:139415731	chr7:139728488	ENST00000406875	-	2	15	539_844	367.6666666666667	1199.0	SKI and SMAD1
Hgene	HIPK2	chr7:139415731	chr7:139728488	ENST00000428878	-	2	15	539_844	367.6666666666667	1172.0	SKI and SMAD1
Hgene	HIPK2	chr7:139415730	chr7:139726147	ENST00000406875	-	2	15	846_941	367.6666666666667	1199.0	TP53 and TP73
Hgene	HIPK2	chr7:139415730	chr7:139726147	ENST00000428878	-	2	15	846_941	367.6666666666667	1172.0	TP53 and TP73
Hgene	HIPK2	chr7:139415730	chr7:139726148	ENST00000406875	-	2	15	846_941	367.6666666666667	1199.0	TP53 and TP73
Hgene	HIPK2	chr7:139415730	chr7:139726148	ENST00000428878	-	2	15	846_941	367.6666666666667	1172.0	TP53 and TP73
Hgene	HIPK2	chr7:139415730	chr7:139728487	ENST00000406875	-	2	15	846_941	367.6666666666667	1199.0	TP53 and TP73
Hgene	HIPK2	chr7:139415730	chr7:139728487	ENST00000428878	-	2	15	846_941	367.6666666666667	1172.0	TP53 and TP73
Hgene	HIPK2	chr7:139415730	chr7:139728488	ENST00000406875	-	2	15	846_941	367.6666666666667	1199.0	TP53 and TP73
Hgene	HIPK2	chr7:139415730	chr7:139728488	ENST00000428878	-	2	15	846_941	367.6666666666667	1172.0	TP53 and TP73
Hgene	HIPK2	chr7:139415731	chr7:139726148	ENST00000406875	-	2	15	846_941	367.6666666666667	1199.0	TP53 and TP73
Hgene	HIPK2	chr7:139415731	chr7:139726148	ENST00000428878	-	2	15	846_941	367.6666666666667	1172.0	TP53 and TP73
Hgene	HIPK2	chr7:139415731	chr7:139728488	ENST00000406875	-	2	15	846_941	367.6666666666667	1199.0	TP53 and TP73
Hgene	HIPK2	chr7:139415731	chr7:139728488	ENST00000428878	-	2	15	846_941	367.6666666666667	1172.0	TP53 and TP73
Hgene	HIPK2	chr7:139415730	chr7:139726147	ENST00000406875	-	2	15	873_907	367.6666666666667	1199.0	UBE2I
Hgene	HIPK2	chr7:139415730	chr7:139726147	ENST00000428878	-	2	15	873_907	367.6666666666667	1172.0	UBE2I
Hgene	HIPK2	chr7:139415730	chr7:139726148	ENST00000406875	-	2	15	873_907	367.6666666666667	1199.0	UBE2I
Hgene	HIPK2	chr7:139415730	chr7:139726148	ENST00000428878	-	2	15	873_907	367.6666666666667	1172.0	UBE2I
Hgene	HIPK2	chr7:139415730	chr7:139728487	ENST00000406875	-	2	15	873_907	367.6666666666667	1199.0	UBE2I
Hgene	HIPK2	chr7:139415730	chr7:139728487	ENST00000428878	-	2	15	873_907	367.6666666666667	1172.0	UBE2I
Hgene	HIPK2	chr7:139415730	chr7:139728488	ENST00000406875	-	2	15	873_907	367.6666666666667	1199.0	UBE2I
Hgene	HIPK2	chr7:139415730	chr7:139728488	ENST00000428878	-	2	15	873_907	367.6666666666667	1172.0	UBE2I
Hgene	HIPK2	chr7:139415731	chr7:139726148	ENST00000406875	-	2	15	873_907	367.6666666666667	1199.0	UBE2I
Hgene	HIPK2	chr7:139415731	chr7:139726148	ENST00000428878	-	2	15	873_907	367.6666666666667	1172.0	UBE2I
Hgene	HIPK2	chr7:139415731	chr7:139728488	ENST00000406875	-	2	15	873_907	367.6666666666667	1199.0	UBE2I
Hgene	HIPK2	chr7:139415731	chr7:139728488	ENST00000428878	-	2	15	873_907	367.6666666666667	1172.0	UBE2I

Top

Related Drugs to HIPK2-PARP12

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to HIPK2-PARP12

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source