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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:HIPK2-TBXAS1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: HIPK2-TBXAS1
FusionPDB ID: 36414
FusionGDB2.0 ID: 36414
HgeneTgene
Gene symbol

HIPK2

TBXAS1

Gene ID

28996

6916

Gene namehomeodomain interacting protein kinase 2thromboxane A synthase 1
SynonymsPRO0593BDPLT14|CYP5|CYP5A1|GHOSAL|THAS|TS|TXAS|TXS
Cytomap

7q34

7q34

Type of geneprotein-codingprotein-coding
Descriptionhomeodomain-interacting protein kinase 2hHIPk2thromboxane-A synthaseTXA synthasecytochrome P450 5A1cytochrome P450, family 5, subfamily A, polypeptide 1platelet, cytochrome P450, subfamily Vthromboxane A synthase 1 (platelet)
Modification date2020031320200327
UniProtAcc

Q9H2X6

.
Ensembl transtripts involved in fusion geneENST idsENST00000406875, ENST00000428878, 
ENST00000342645, 		ENST00000462275, 
ENST00000263552, ENST00000336425, 
ENST00000425687, ENST00000411653, 
ENST00000414508, ENST00000416849, 
ENST00000436047, ENST00000448866, 
ENST00000455353, ENST00000458722, 
ENST00000539806, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 13 X 12=265210 X 12 X 5=600
# samples 2512
** MAII scorelog2(25/2652*10)=-3.4070807754505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/600*10)=-2.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: HIPK2 [Title/Abstract] AND TBXAS1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)HIPK2(139477403)-TBXAS1(139706890), # samples:1
HIPK2(139477404)-TBXAS1(139706891), # samples:1
HIPK2(139477404)-TBXAS1(139487137), # samples:1
HIPK2(139477404)-TBXAS1(139482465), # samples:1
Anticipated loss of major functional domain due to fusion event.HIPK2-TBXAS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HIPK2-TBXAS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHIPK2

GO:0006468

protein phosphorylation

19448668

HgeneHIPK2

GO:0006978

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

14647468

HgeneHIPK2

GO:0045766

positive regulation of angiogenesis

19046997

HgeneHIPK2

GO:0060395

SMAD protein signal transduction

12874272


check buttonFusion gene breakpoints across HIPK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TBXAS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GH-01AHIPK2chr7

139477404

-TBXAS1chr7

139482465

+
ChimerDB4STADTCGA-HU-A4GH-01AHIPK2chr7

139477404

-TBXAS1chr7

139487137

+
ChimerDB4STADTCGA-HU-A4GT-01AHIPK2chr7

139477404

-TBXAS1chr7

139706891

+
ChimerDB4STADTCGA-HU-A4GTHIPK2chr7

139477403

-TBXAS1chr7

139706890

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000406875HIPK2chr7139477403-ENST00000425687TBXAS1chr7139706890+772114114581155
ENST00000406875HIPK2chr7139477403-ENST00000263552TBXAS1chr7139706890+806114114581155
ENST00000406875HIPK2chr7139477403-ENST00000336425TBXAS1chr7139706890+776114114581155
ENST00000406875HIPK2chr7139477403-ENST00000436047TBXAS1chr7139706890+806114114581155
ENST00000406875HIPK2chr7139477403-ENST00000416849TBXAS1chr7139706890+806114114581155
ENST00000406875HIPK2chr7139477403-ENST00000414508TBXAS1chr7139706890+643114248083
ENST00000406875HIPK2chr7139477403-ENST00000448866TBXAS1chr7139706890+776114114581155
ENST00000428878HIPK2chr7139477403-ENST00000425687TBXAS1chr7139706890+832174174641155
ENST00000428878HIPK2chr7139477403-ENST00000263552TBXAS1chr7139706890+866174174641155
ENST00000428878HIPK2chr7139477403-ENST00000336425TBXAS1chr7139706890+836174174641155
ENST00000428878HIPK2chr7139477403-ENST00000436047TBXAS1chr7139706890+866174174641155
ENST00000428878HIPK2chr7139477403-ENST00000416849TBXAS1chr7139706890+866174174641155
ENST00000428878HIPK2chr7139477403-ENST00000414508TBXAS1chr7139706890+7031743080103
ENST00000428878HIPK2chr7139477403-ENST00000448866TBXAS1chr7139706890+836174174641155
ENST00000406875HIPK2chr7139477404-ENST00000425687TBXAS1chr7139706891+772114114581155
ENST00000406875HIPK2chr7139477404-ENST00000263552TBXAS1chr7139706891+806114114581155
ENST00000406875HIPK2chr7139477404-ENST00000336425TBXAS1chr7139706891+776114114581155
ENST00000406875HIPK2chr7139477404-ENST00000436047TBXAS1chr7139706891+806114114581155
ENST00000406875HIPK2chr7139477404-ENST00000416849TBXAS1chr7139706891+806114114581155
ENST00000406875HIPK2chr7139477404-ENST00000414508TBXAS1chr7139706891+643114248083
ENST00000406875HIPK2chr7139477404-ENST00000448866TBXAS1chr7139706891+776114114581155
ENST00000428878HIPK2chr7139477404-ENST00000425687TBXAS1chr7139706891+832174174641155
ENST00000428878HIPK2chr7139477404-ENST00000263552TBXAS1chr7139706891+866174174641155
ENST00000428878HIPK2chr7139477404-ENST00000336425TBXAS1chr7139706891+836174174641155
ENST00000428878HIPK2chr7139477404-ENST00000436047TBXAS1chr7139706891+866174174641155
ENST00000428878HIPK2chr7139477404-ENST00000416849TBXAS1chr7139706891+866174174641155
ENST00000428878HIPK2chr7139477404-ENST00000414508TBXAS1chr7139706891+7031743080103
ENST00000428878HIPK2chr7139477404-ENST00000448866TBXAS1chr7139706891+836174174641155

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000406875ENST00000425687HIPK2chr7139477403-TBXAS1chr7139706890+0.032400240.96759975
ENST00000406875ENST00000263552HIPK2chr7139477403-TBXAS1chr7139706890+0.0343903270.9656096
ENST00000406875ENST00000336425HIPK2chr7139477403-TBXAS1chr7139706890+0.0303943790.9696056
ENST00000406875ENST00000436047HIPK2chr7139477403-TBXAS1chr7139706890+0.0343903270.9656096
ENST00000406875ENST00000416849HIPK2chr7139477403-TBXAS1chr7139706890+0.0343903270.9656096
ENST00000406875ENST00000414508HIPK2chr7139477403-TBXAS1chr7139706890+0.10386080.89613914
ENST00000406875ENST00000448866HIPK2chr7139477403-TBXAS1chr7139706890+0.0303943790.9696056
ENST00000428878ENST00000425687HIPK2chr7139477403-TBXAS1chr7139706890+0.0311439950.968856
ENST00000428878ENST00000263552HIPK2chr7139477403-TBXAS1chr7139706890+0.029193950.97080606
ENST00000428878ENST00000336425HIPK2chr7139477403-TBXAS1chr7139706890+0.0289247950.97107524
ENST00000428878ENST00000436047HIPK2chr7139477403-TBXAS1chr7139706890+0.029193950.97080606
ENST00000428878ENST00000416849HIPK2chr7139477403-TBXAS1chr7139706890+0.029193950.97080606
ENST00000428878ENST00000414508HIPK2chr7139477403-TBXAS1chr7139706890+0.085139290.91486067
ENST00000428878ENST00000448866HIPK2chr7139477403-TBXAS1chr7139706890+0.0289247950.97107524
ENST00000406875ENST00000425687HIPK2chr7139477404-TBXAS1chr7139706891+0.032400240.96759975
ENST00000406875ENST00000263552HIPK2chr7139477404-TBXAS1chr7139706891+0.0343903270.9656096
ENST00000406875ENST00000336425HIPK2chr7139477404-TBXAS1chr7139706891+0.0303943790.9696056
ENST00000406875ENST00000436047HIPK2chr7139477404-TBXAS1chr7139706891+0.0343903270.9656096
ENST00000406875ENST00000416849HIPK2chr7139477404-TBXAS1chr7139706891+0.0343903270.9656096
ENST00000406875ENST00000414508HIPK2chr7139477404-TBXAS1chr7139706891+0.10386080.89613914
ENST00000406875ENST00000448866HIPK2chr7139477404-TBXAS1chr7139706891+0.0303943790.9696056
ENST00000428878ENST00000425687HIPK2chr7139477404-TBXAS1chr7139706891+0.0311439950.968856
ENST00000428878ENST00000263552HIPK2chr7139477404-TBXAS1chr7139706891+0.029193950.97080606
ENST00000428878ENST00000336425HIPK2chr7139477404-TBXAS1chr7139706891+0.0289247950.97107524
ENST00000428878ENST00000436047HIPK2chr7139477404-TBXAS1chr7139706891+0.029193950.97080606
ENST00000428878ENST00000416849HIPK2chr7139477404-TBXAS1chr7139706891+0.029193950.97080606
ENST00000428878ENST00000414508HIPK2chr7139477404-TBXAS1chr7139706891+0.085139290.91486067
ENST00000428878ENST00000448866HIPK2chr7139477404-TBXAS1chr7139706891+0.0289247950.97107524

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>36414_36414_1_HIPK2-TBXAS1_HIPK2_chr7_139477403_ENST00000406875_TBXAS1_chr7_139706890_ENST00000263552_length(amino acids)=155AA_BP=0
MAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFT

--------------------------------------------------------------

>36414_36414_2_HIPK2-TBXAS1_HIPK2_chr7_139477403_ENST00000406875_TBXAS1_chr7_139706890_ENST00000336425_length(amino acids)=155AA_BP=0
MAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFT

--------------------------------------------------------------

>36414_36414_3_HIPK2-TBXAS1_HIPK2_chr7_139477403_ENST00000406875_TBXAS1_chr7_139706890_ENST00000414508_length(amino acids)=83AA_BP=1

--------------------------------------------------------------

>36414_36414_4_HIPK2-TBXAS1_HIPK2_chr7_139477403_ENST00000406875_TBXAS1_chr7_139706890_ENST00000416849_length(amino acids)=155AA_BP=0
MAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFT

--------------------------------------------------------------

>36414_36414_5_HIPK2-TBXAS1_HIPK2_chr7_139477403_ENST00000406875_TBXAS1_chr7_139706890_ENST00000425687_length(amino acids)=155AA_BP=0
MAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFT

--------------------------------------------------------------

>36414_36414_6_HIPK2-TBXAS1_HIPK2_chr7_139477403_ENST00000406875_TBXAS1_chr7_139706890_ENST00000436047_length(amino acids)=155AA_BP=0
MAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFT

--------------------------------------------------------------

>36414_36414_7_HIPK2-TBXAS1_HIPK2_chr7_139477403_ENST00000406875_TBXAS1_chr7_139706890_ENST00000448866_length(amino acids)=155AA_BP=0
MAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFT

--------------------------------------------------------------

>36414_36414_8_HIPK2-TBXAS1_HIPK2_chr7_139477403_ENST00000428878_TBXAS1_chr7_139706890_ENST00000263552_length(amino acids)=155AA_BP=0
MAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFT

--------------------------------------------------------------

>36414_36414_9_HIPK2-TBXAS1_HIPK2_chr7_139477403_ENST00000428878_TBXAS1_chr7_139706890_ENST00000336425_length(amino acids)=155AA_BP=0
MAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFT

--------------------------------------------------------------

>36414_36414_10_HIPK2-TBXAS1_HIPK2_chr7_139477403_ENST00000428878_TBXAS1_chr7_139706890_ENST00000414508_length(amino acids)=103AA_BP=1
MPQHLAVLSCLPCESESWRVHPQRLCNHHVQIGQAFLEAAELRGHLRTRGPSGPGCPRFMATGTGKRRASSAPPASVGICHLEPVSPLSA

--------------------------------------------------------------

>36414_36414_11_HIPK2-TBXAS1_HIPK2_chr7_139477403_ENST00000428878_TBXAS1_chr7_139706890_ENST00000416849_length(amino acids)=155AA_BP=0
MAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFT

--------------------------------------------------------------

>36414_36414_12_HIPK2-TBXAS1_HIPK2_chr7_139477403_ENST00000428878_TBXAS1_chr7_139706890_ENST00000425687_length(amino acids)=155AA_BP=0
MAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFT

--------------------------------------------------------------

>36414_36414_13_HIPK2-TBXAS1_HIPK2_chr7_139477403_ENST00000428878_TBXAS1_chr7_139706890_ENST00000436047_length(amino acids)=155AA_BP=0
MAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFT

--------------------------------------------------------------

>36414_36414_14_HIPK2-TBXAS1_HIPK2_chr7_139477403_ENST00000428878_TBXAS1_chr7_139706890_ENST00000448866_length(amino acids)=155AA_BP=0
MAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFT

--------------------------------------------------------------

>36414_36414_15_HIPK2-TBXAS1_HIPK2_chr7_139477404_ENST00000406875_TBXAS1_chr7_139706891_ENST00000263552_length(amino acids)=155AA_BP=0
MAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFT

--------------------------------------------------------------

>36414_36414_16_HIPK2-TBXAS1_HIPK2_chr7_139477404_ENST00000406875_TBXAS1_chr7_139706891_ENST00000336425_length(amino acids)=155AA_BP=0
MAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFT

--------------------------------------------------------------

>36414_36414_17_HIPK2-TBXAS1_HIPK2_chr7_139477404_ENST00000406875_TBXAS1_chr7_139706891_ENST00000414508_length(amino acids)=83AA_BP=1

--------------------------------------------------------------

>36414_36414_18_HIPK2-TBXAS1_HIPK2_chr7_139477404_ENST00000406875_TBXAS1_chr7_139706891_ENST00000416849_length(amino acids)=155AA_BP=0
MAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFT

--------------------------------------------------------------

>36414_36414_19_HIPK2-TBXAS1_HIPK2_chr7_139477404_ENST00000406875_TBXAS1_chr7_139706891_ENST00000425687_length(amino acids)=155AA_BP=0
MAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFT

--------------------------------------------------------------

>36414_36414_20_HIPK2-TBXAS1_HIPK2_chr7_139477404_ENST00000406875_TBXAS1_chr7_139706891_ENST00000436047_length(amino acids)=155AA_BP=0
MAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFT

--------------------------------------------------------------

>36414_36414_21_HIPK2-TBXAS1_HIPK2_chr7_139477404_ENST00000406875_TBXAS1_chr7_139706891_ENST00000448866_length(amino acids)=155AA_BP=0
MAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFT

--------------------------------------------------------------

>36414_36414_22_HIPK2-TBXAS1_HIPK2_chr7_139477404_ENST00000428878_TBXAS1_chr7_139706891_ENST00000263552_length(amino acids)=155AA_BP=0
MAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFT

--------------------------------------------------------------

>36414_36414_23_HIPK2-TBXAS1_HIPK2_chr7_139477404_ENST00000428878_TBXAS1_chr7_139706891_ENST00000336425_length(amino acids)=155AA_BP=0
MAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFT

--------------------------------------------------------------

>36414_36414_24_HIPK2-TBXAS1_HIPK2_chr7_139477404_ENST00000428878_TBXAS1_chr7_139706891_ENST00000414508_length(amino acids)=103AA_BP=1
MPQHLAVLSCLPCESESWRVHPQRLCNHHVQIGQAFLEAAELRGHLRTRGPSGPGCPRFMATGTGKRRASSAPPASVGICHLEPVSPLSA

--------------------------------------------------------------

>36414_36414_25_HIPK2-TBXAS1_HIPK2_chr7_139477404_ENST00000428878_TBXAS1_chr7_139706891_ENST00000416849_length(amino acids)=155AA_BP=0
MAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFT

--------------------------------------------------------------

>36414_36414_26_HIPK2-TBXAS1_HIPK2_chr7_139477404_ENST00000428878_TBXAS1_chr7_139706891_ENST00000425687_length(amino acids)=155AA_BP=0
MAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFT

--------------------------------------------------------------

>36414_36414_27_HIPK2-TBXAS1_HIPK2_chr7_139477404_ENST00000428878_TBXAS1_chr7_139706891_ENST00000436047_length(amino acids)=155AA_BP=0
MAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFT

--------------------------------------------------------------

>36414_36414_28_HIPK2-TBXAS1_HIPK2_chr7_139477404_ENST00000428878_TBXAS1_chr7_139706891_ENST00000448866_length(amino acids)=155AA_BP=0
MAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFT

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:139477403/chr7:139706890)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HIPK2

Q9H2X6

.
FUNCTION: Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. {ECO:0000269|PubMed:11740489, ECO:0000269|PubMed:11925430, ECO:0000269|PubMed:12851404, ECO:0000269|PubMed:12874272, ECO:0000269|PubMed:14678985, ECO:0000269|PubMed:17018294, ECO:0000269|PubMed:17960875, ECO:0000269|PubMed:18695000, ECO:0000269|PubMed:18809579, ECO:0000269|PubMed:19015637, ECO:0000269|PubMed:19046997, ECO:0000269|PubMed:19448668, ECO:0000269|PubMed:20307497, ECO:0000269|PubMed:20573984, ECO:0000269|PubMed:20637728, ECO:0000269|PubMed:20980392, ECO:0000269|PubMed:21192925, ECO:0000269|PubMed:22825850}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTBXAS1chr7:139477403chr7:139706890ENST000004256871015357_533311.0467.0Topological domainCytoplasmic
TgeneTBXAS1chr7:139477404chr7:139706891ENST000004256871015357_533311.0467.0Topological domainCytoplasmic
TgeneTBXAS1chr7:139477403chr7:139706890ENST000004256871015336_356311.0467.0TransmembraneHelical
TgeneTBXAS1chr7:139477404chr7:139706891ENST000004256871015336_356311.0467.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHIPK2chr7:139477403chr7:139706890ENST00000406875-1151088_10946.3333333333333331199.0Compositional biasNote=Poly-Ala
HgeneHIPK2chr7:139477403chr7:139706890ENST00000428878-1151088_10946.3333333333333331172.0Compositional biasNote=Poly-Ala
HgeneHIPK2chr7:139477404chr7:139706891ENST00000406875-1151088_10946.3333333333333331199.0Compositional biasNote=Poly-Ala
HgeneHIPK2chr7:139477404chr7:139706891ENST00000428878-1151088_10946.3333333333333331172.0Compositional biasNote=Poly-Ala
HgeneHIPK2chr7:139477403chr7:139706890ENST00000406875-115199_5276.3333333333333331199.0DomainProtein kinase
HgeneHIPK2chr7:139477403chr7:139706890ENST00000428878-115199_5276.3333333333333331172.0DomainProtein kinase
HgeneHIPK2chr7:139477404chr7:139706891ENST00000406875-115199_5276.3333333333333331199.0DomainProtein kinase
HgeneHIPK2chr7:139477404chr7:139706891ENST00000428878-115199_5276.3333333333333331172.0DomainProtein kinase
HgeneHIPK2chr7:139477403chr7:139706890ENST00000406875-115802_8056.3333333333333331199.0MotifNote=Nuclear localization signal 1 (NLS1)
HgeneHIPK2chr7:139477403chr7:139706890ENST00000406875-115832_8356.3333333333333331199.0MotifNote=Nuclear localization signal 2 (NLS2)
HgeneHIPK2chr7:139477403chr7:139706890ENST00000428878-115802_8056.3333333333333331172.0MotifNote=Nuclear localization signal 1 (NLS1)
HgeneHIPK2chr7:139477403chr7:139706890ENST00000428878-115832_8356.3333333333333331172.0MotifNote=Nuclear localization signal 2 (NLS2)
HgeneHIPK2chr7:139477404chr7:139706891ENST00000406875-115802_8056.3333333333333331199.0MotifNote=Nuclear localization signal 1 (NLS1)
HgeneHIPK2chr7:139477404chr7:139706891ENST00000406875-115832_8356.3333333333333331199.0MotifNote=Nuclear localization signal 2 (NLS2)
HgeneHIPK2chr7:139477404chr7:139706891ENST00000428878-115802_8056.3333333333333331172.0MotifNote=Nuclear localization signal 1 (NLS1)
HgeneHIPK2chr7:139477404chr7:139706891ENST00000428878-115832_8356.3333333333333331172.0MotifNote=Nuclear localization signal 2 (NLS2)
HgeneHIPK2chr7:139477403chr7:139706890ENST00000406875-115205_2136.3333333333333331199.0Nucleotide bindingATP
HgeneHIPK2chr7:139477403chr7:139706890ENST00000428878-115205_2136.3333333333333331172.0Nucleotide bindingATP
HgeneHIPK2chr7:139477404chr7:139706891ENST00000406875-115205_2136.3333333333333331199.0Nucleotide bindingATP
HgeneHIPK2chr7:139477404chr7:139706891ENST00000428878-115205_2136.3333333333333331172.0Nucleotide bindingATP
HgeneHIPK2chr7:139477403chr7:139706890ENST00000406875-115873_9806.3333333333333331199.0RegionRequired for localization to nuclear speckles
HgeneHIPK2chr7:139477403chr7:139706890ENST00000406875-11597_2306.3333333333333331199.0RegionTranscriptional corepression
HgeneHIPK2chr7:139477403chr7:139706890ENST00000406875-115984_11986.3333333333333331199.0RegionNote=Autoinhibitory domain (AID)
HgeneHIPK2chr7:139477403chr7:139706890ENST00000428878-115873_9806.3333333333333331172.0RegionRequired for localization to nuclear speckles
HgeneHIPK2chr7:139477403chr7:139706890ENST00000428878-11597_2306.3333333333333331172.0RegionTranscriptional corepression
HgeneHIPK2chr7:139477403chr7:139706890ENST00000428878-115984_11986.3333333333333331172.0RegionNote=Autoinhibitory domain (AID)
HgeneHIPK2chr7:139477404chr7:139706891ENST00000406875-115873_9806.3333333333333331199.0RegionRequired for localization to nuclear speckles
HgeneHIPK2chr7:139477404chr7:139706891ENST00000406875-11597_2306.3333333333333331199.0RegionTranscriptional corepression
HgeneHIPK2chr7:139477404chr7:139706891ENST00000406875-115984_11986.3333333333333331199.0RegionNote=Autoinhibitory domain (AID)
HgeneHIPK2chr7:139477404chr7:139706891ENST00000428878-115873_9806.3333333333333331172.0RegionRequired for localization to nuclear speckles
HgeneHIPK2chr7:139477404chr7:139706891ENST00000428878-11597_2306.3333333333333331172.0RegionTranscriptional corepression
HgeneHIPK2chr7:139477404chr7:139706891ENST00000428878-115984_11986.3333333333333331172.0RegionNote=Autoinhibitory domain (AID)
TgeneTBXAS1chr7:139477403chr7:139706890ENST0000026355212171_10379.0535.0Topological domainCytoplasmic
TgeneTBXAS1chr7:139477403chr7:139706890ENST000002635521217245_335379.0535.0Topological domainLumenal
TgeneTBXAS1chr7:139477403chr7:139706890ENST00000263552121732_75379.0535.0Topological domainLumenal
TgeneTBXAS1chr7:139477403chr7:139706890ENST000002635521217357_533379.0535.0Topological domainCytoplasmic
TgeneTBXAS1chr7:139477403chr7:139706890ENST00000263552121797_223379.0535.0Topological domainCytoplasmic
TgeneTBXAS1chr7:139477403chr7:139706890ENST0000033642512171_10378.0534.0Topological domainCytoplasmic
TgeneTBXAS1chr7:139477403chr7:139706890ENST000003364251217245_335378.0534.0Topological domainLumenal
TgeneTBXAS1chr7:139477403chr7:139706890ENST00000336425121732_75378.0534.0Topological domainLumenal
TgeneTBXAS1chr7:139477403chr7:139706890ENST000003364251217357_533378.0534.0Topological domainCytoplasmic
TgeneTBXAS1chr7:139477403chr7:139706890ENST00000336425121797_223378.0534.0Topological domainCytoplasmic
TgeneTBXAS1chr7:139477403chr7:139706890ENST0000042568710151_10311.0467.0Topological domainCytoplasmic
TgeneTBXAS1chr7:139477403chr7:139706890ENST000004256871015245_335311.0467.0Topological domainLumenal
TgeneTBXAS1chr7:139477403chr7:139706890ENST00000425687101532_75311.0467.0Topological domainLumenal
TgeneTBXAS1chr7:139477403chr7:139706890ENST00000425687101597_223311.0467.0Topological domainCytoplasmic
TgeneTBXAS1chr7:139477403chr7:139706890ENST000004360478131_10379.0535.0Topological domainCytoplasmic
TgeneTBXAS1chr7:139477403chr7:139706890ENST00000436047813245_335379.0535.0Topological domainLumenal
TgeneTBXAS1chr7:139477403chr7:139706890ENST0000043604781332_75379.0535.0Topological domainLumenal
TgeneTBXAS1chr7:139477403chr7:139706890ENST00000436047813357_533379.0535.0Topological domainCytoplasmic
TgeneTBXAS1chr7:139477403chr7:139706890ENST0000043604781397_223379.0535.0Topological domainCytoplasmic
TgeneTBXAS1chr7:139477403chr7:139706890ENST000004488668131_10378.0534.0Topological domainCytoplasmic
TgeneTBXAS1chr7:139477403chr7:139706890ENST00000448866813245_335378.0534.0Topological domainLumenal
TgeneTBXAS1chr7:139477403chr7:139706890ENST0000044886681332_75378.0534.0Topological domainLumenal
TgeneTBXAS1chr7:139477403chr7:139706890ENST00000448866813357_533378.0534.0Topological domainCytoplasmic
TgeneTBXAS1chr7:139477403chr7:139706890ENST0000044886681397_223378.0534.0Topological domainCytoplasmic
TgeneTBXAS1chr7:139477404chr7:139706891ENST0000026355212171_10379.0535.0Topological domainCytoplasmic
TgeneTBXAS1chr7:139477404chr7:139706891ENST000002635521217245_335379.0535.0Topological domainLumenal
TgeneTBXAS1chr7:139477404chr7:139706891ENST00000263552121732_75379.0535.0Topological domainLumenal
TgeneTBXAS1chr7:139477404chr7:139706891ENST000002635521217357_533379.0535.0Topological domainCytoplasmic
TgeneTBXAS1chr7:139477404chr7:139706891ENST00000263552121797_223379.0535.0Topological domainCytoplasmic
TgeneTBXAS1chr7:139477404chr7:139706891ENST0000033642512171_10378.0534.0Topological domainCytoplasmic
TgeneTBXAS1chr7:139477404chr7:139706891ENST000003364251217245_335378.0534.0Topological domainLumenal
TgeneTBXAS1chr7:139477404chr7:139706891ENST00000336425121732_75378.0534.0Topological domainLumenal
TgeneTBXAS1chr7:139477404chr7:139706891ENST000003364251217357_533378.0534.0Topological domainCytoplasmic
TgeneTBXAS1chr7:139477404chr7:139706891ENST00000336425121797_223378.0534.0Topological domainCytoplasmic
TgeneTBXAS1chr7:139477404chr7:139706891ENST0000042568710151_10311.0467.0Topological domainCytoplasmic
TgeneTBXAS1chr7:139477404chr7:139706891ENST000004256871015245_335311.0467.0Topological domainLumenal
TgeneTBXAS1chr7:139477404chr7:139706891ENST00000425687101532_75311.0467.0Topological domainLumenal
TgeneTBXAS1chr7:139477404chr7:139706891ENST00000425687101597_223311.0467.0Topological domainCytoplasmic
TgeneTBXAS1chr7:139477404chr7:139706891ENST000004360478131_10379.0535.0Topological domainCytoplasmic
TgeneTBXAS1chr7:139477404chr7:139706891ENST00000436047813245_335379.0535.0Topological domainLumenal
TgeneTBXAS1chr7:139477404chr7:139706891ENST0000043604781332_75379.0535.0Topological domainLumenal
TgeneTBXAS1chr7:139477404chr7:139706891ENST00000436047813357_533379.0535.0Topological domainCytoplasmic
TgeneTBXAS1chr7:139477404chr7:139706891ENST0000043604781397_223379.0535.0Topological domainCytoplasmic
TgeneTBXAS1chr7:139477404chr7:139706891ENST000004488668131_10378.0534.0Topological domainCytoplasmic
TgeneTBXAS1chr7:139477404chr7:139706891ENST00000448866813245_335378.0534.0Topological domainLumenal
TgeneTBXAS1chr7:139477404chr7:139706891ENST0000044886681332_75378.0534.0Topological domainLumenal
TgeneTBXAS1chr7:139477404chr7:139706891ENST00000448866813357_533378.0534.0Topological domainCytoplasmic
TgeneTBXAS1chr7:139477404chr7:139706891ENST0000044886681397_223378.0534.0Topological domainCytoplasmic
TgeneTBXAS1chr7:139477403chr7:139706890ENST00000263552121711_31379.0535.0TransmembraneHelical
TgeneTBXAS1chr7:139477403chr7:139706890ENST000002635521217224_244379.0535.0TransmembraneHelical
TgeneTBXAS1chr7:139477403chr7:139706890ENST000002635521217336_356379.0535.0TransmembraneHelical
TgeneTBXAS1chr7:139477403chr7:139706890ENST00000263552121776_96379.0535.0TransmembraneHelical
TgeneTBXAS1chr7:139477403chr7:139706890ENST00000336425121711_31378.0534.0TransmembraneHelical
TgeneTBXAS1chr7:139477403chr7:139706890ENST000003364251217224_244378.0534.0TransmembraneHelical
TgeneTBXAS1chr7:139477403chr7:139706890ENST000003364251217336_356378.0534.0TransmembraneHelical
TgeneTBXAS1chr7:139477403chr7:139706890ENST00000336425121776_96378.0534.0TransmembraneHelical
TgeneTBXAS1chr7:139477403chr7:139706890ENST00000425687101511_31311.0467.0TransmembraneHelical
TgeneTBXAS1chr7:139477403chr7:139706890ENST000004256871015224_244311.0467.0TransmembraneHelical
TgeneTBXAS1chr7:139477403chr7:139706890ENST00000425687101576_96311.0467.0TransmembraneHelical
TgeneTBXAS1chr7:139477403chr7:139706890ENST0000043604781311_31379.0535.0TransmembraneHelical
TgeneTBXAS1chr7:139477403chr7:139706890ENST00000436047813224_244379.0535.0TransmembraneHelical
TgeneTBXAS1chr7:139477403chr7:139706890ENST00000436047813336_356379.0535.0TransmembraneHelical
TgeneTBXAS1chr7:139477403chr7:139706890ENST0000043604781376_96379.0535.0TransmembraneHelical
TgeneTBXAS1chr7:139477403chr7:139706890ENST0000044886681311_31378.0534.0TransmembraneHelical
TgeneTBXAS1chr7:139477403chr7:139706890ENST00000448866813224_244378.0534.0TransmembraneHelical
TgeneTBXAS1chr7:139477403chr7:139706890ENST00000448866813336_356378.0534.0TransmembraneHelical
TgeneTBXAS1chr7:139477403chr7:139706890ENST0000044886681376_96378.0534.0TransmembraneHelical
TgeneTBXAS1chr7:139477404chr7:139706891ENST00000263552121711_31379.0535.0TransmembraneHelical
TgeneTBXAS1chr7:139477404chr7:139706891ENST000002635521217224_244379.0535.0TransmembraneHelical
TgeneTBXAS1chr7:139477404chr7:139706891ENST000002635521217336_356379.0535.0TransmembraneHelical
TgeneTBXAS1chr7:139477404chr7:139706891ENST00000263552121776_96379.0535.0TransmembraneHelical
TgeneTBXAS1chr7:139477404chr7:139706891ENST00000336425121711_31378.0534.0TransmembraneHelical
TgeneTBXAS1chr7:139477404chr7:139706891ENST000003364251217224_244378.0534.0TransmembraneHelical
TgeneTBXAS1chr7:139477404chr7:139706891ENST000003364251217336_356378.0534.0TransmembraneHelical
TgeneTBXAS1chr7:139477404chr7:139706891ENST00000336425121776_96378.0534.0TransmembraneHelical
TgeneTBXAS1chr7:139477404chr7:139706891ENST00000425687101511_31311.0467.0TransmembraneHelical
TgeneTBXAS1chr7:139477404chr7:139706891ENST000004256871015224_244311.0467.0TransmembraneHelical
TgeneTBXAS1chr7:139477404chr7:139706891ENST00000425687101576_96311.0467.0TransmembraneHelical
TgeneTBXAS1chr7:139477404chr7:139706891ENST0000043604781311_31379.0535.0TransmembraneHelical
TgeneTBXAS1chr7:139477404chr7:139706891ENST00000436047813224_244379.0535.0TransmembraneHelical
TgeneTBXAS1chr7:139477404chr7:139706891ENST00000436047813336_356379.0535.0TransmembraneHelical
TgeneTBXAS1chr7:139477404chr7:139706891ENST0000043604781376_96379.0535.0TransmembraneHelical
TgeneTBXAS1chr7:139477404chr7:139706891ENST0000044886681311_31378.0534.0TransmembraneHelical
TgeneTBXAS1chr7:139477404chr7:139706891ENST00000448866813224_244378.0534.0TransmembraneHelical
TgeneTBXAS1chr7:139477404chr7:139706891ENST00000448866813336_356378.0534.0TransmembraneHelical
TgeneTBXAS1chr7:139477404chr7:139706891ENST0000044886681376_96378.0534.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
HIPK2
TBXAS1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneHIPK2chr7:139477403chr7:139706890ENST00000406875-115935_10496.3333333333333331199.0AXIN1
HgeneHIPK2chr7:139477403chr7:139706890ENST00000428878-115935_10496.3333333333333331172.0AXIN1
HgeneHIPK2chr7:139477404chr7:139706891ENST00000406875-115935_10496.3333333333333331199.0AXIN1
HgeneHIPK2chr7:139477404chr7:139706891ENST00000428878-115935_10496.3333333333333331172.0AXIN1
HgeneHIPK2chr7:139477403chr7:139706890ENST00000406875-115774_8766.3333333333333331199.0CTBP1
HgeneHIPK2chr7:139477403chr7:139706890ENST00000428878-115774_8766.3333333333333331172.0CTBP1
HgeneHIPK2chr7:139477404chr7:139706891ENST00000406875-115774_8766.3333333333333331199.0CTBP1
HgeneHIPK2chr7:139477404chr7:139706891ENST00000428878-115774_8766.3333333333333331172.0CTBP1
HgeneHIPK2chr7:139477403chr7:139706890ENST00000406875-115189_5206.3333333333333331199.0DAXX
HgeneHIPK2chr7:139477403chr7:139706890ENST00000428878-115189_5206.3333333333333331172.0DAXX
HgeneHIPK2chr7:139477404chr7:139706891ENST00000406875-115189_5206.3333333333333331199.0DAXX
HgeneHIPK2chr7:139477404chr7:139706891ENST00000428878-115189_5206.3333333333333331172.0DAXX
HgeneHIPK2chr7:139477403chr7:139706890ENST00000406875-115787_8976.3333333333333331199.0HMGA1
HgeneHIPK2chr7:139477403chr7:139706890ENST00000428878-115787_8976.3333333333333331172.0HMGA1
HgeneHIPK2chr7:139477404chr7:139706891ENST00000406875-115787_8976.3333333333333331199.0HMGA1
HgeneHIPK2chr7:139477404chr7:139706891ENST00000428878-115787_8976.3333333333333331172.0HMGA1
HgeneHIPK2chr7:139477403chr7:139706890ENST00000406875-115752_8976.3333333333333331199.0POU4F1
HgeneHIPK2chr7:139477403chr7:139706890ENST00000428878-115752_8976.3333333333333331172.0POU4F1
HgeneHIPK2chr7:139477404chr7:139706891ENST00000406875-115752_8976.3333333333333331199.0POU4F1
HgeneHIPK2chr7:139477404chr7:139706891ENST00000428878-115752_8976.3333333333333331172.0POU4F1
HgeneHIPK2chr7:139477403chr7:139706890ENST00000406875-115539_8446.3333333333333331199.0SKI and SMAD1
HgeneHIPK2chr7:139477403chr7:139706890ENST00000428878-115539_8446.3333333333333331172.0SKI and SMAD1
HgeneHIPK2chr7:139477404chr7:139706891ENST00000406875-115539_8446.3333333333333331199.0SKI and SMAD1
HgeneHIPK2chr7:139477404chr7:139706891ENST00000428878-115539_8446.3333333333333331172.0SKI and SMAD1
HgeneHIPK2chr7:139477403chr7:139706890ENST00000406875-115846_9416.3333333333333331199.0TP53 and TP73
HgeneHIPK2chr7:139477403chr7:139706890ENST00000428878-115846_9416.3333333333333331172.0TP53 and TP73
HgeneHIPK2chr7:139477404chr7:139706891ENST00000406875-115846_9416.3333333333333331199.0TP53 and TP73
HgeneHIPK2chr7:139477404chr7:139706891ENST00000428878-115846_9416.3333333333333331172.0TP53 and TP73
HgeneHIPK2chr7:139477403chr7:139706890ENST00000406875-115873_9076.3333333333333331199.0UBE2I
HgeneHIPK2chr7:139477403chr7:139706890ENST00000428878-115873_9076.3333333333333331172.0UBE2I
HgeneHIPK2chr7:139477404chr7:139706891ENST00000406875-115873_9076.3333333333333331199.0UBE2I
HgeneHIPK2chr7:139477404chr7:139706891ENST00000428878-115873_9076.3333333333333331172.0UBE2I


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Related Drugs to HIPK2-TBXAS1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to HIPK2-TBXAS1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource