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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:HIVEP3-UBR5

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: HIVEP3-UBR5
FusionPDB ID: 36567
FusionGDB2.0 ID: 36567
HgeneTgene
Gene symbol

HIVEP3

UBR5

Gene ID

59269

51366

Gene nameHIVEP zinc finger 3ubiquitin protein ligase E3 component n-recognin 5
SynonymsKBP-1|KBP1|KRC|SHN3|Schnurri-3|ZAS3|ZNF40CDD5|EDD|EDD1|HYD
Cytomap

1p34.2

8q22.3

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor HIVEP3ZAS family, member 3human immunodeficiency virus type I enhancer binding protein 3kappa-B and V(D)J recombination signal sequences-binding proteinkappa-binding protein 1zinc finger protein ZAS3E3 ubiquitin-protein ligase UBR5E3 identified by differential displayE3 ubiquitin-protein ligase, HECT domain-containing 1HECT-type E3 ubiquitin transferase UBR5hyperplastic discs protein homologprogestin-induced protein
Modification date2020031320200315
UniProtAcc

Q5T1R4

.
Ensembl transtripts involved in fusion geneENST idsENST00000247584, ENST00000372583, 
ENST00000372584, ENST00000429157, 
ENST00000460604, 		ENST00000518205, 
ENST00000519528, ENST00000521922, 
ENST00000220959, ENST00000520539, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score21 X 18 X 10=378014 X 17 X 10=2380
# samples 2519
** MAII scorelog2(25/3780*10)=-3.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/2380*10)=-3.64689024986436
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: HIVEP3 [Title/Abstract] AND UBR5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)HIVEP3(42041214)-UBR5(103293747), # samples:2
Anticipated loss of major functional domain due to fusion event.HIVEP3-UBR5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HIVEP3-UBR5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HIVEP3-UBR5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HIVEP3-UBR5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HIVEP3-UBR5 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
HIVEP3-UBR5 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
HIVEP3-UBR5 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
HIVEP3-UBR5 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
HIVEP3-UBR5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHIVEP3

GO:0045893

positive regulation of transcription, DNA-templated

15790681

TgeneUBR5

GO:0000209

protein polyubiquitination

21118991|28689657

TgeneUBR5

GO:0006974

cellular response to DNA damage stimulus

12011095

TgeneUBR5

GO:0010628

positive regulation of gene expression

18076571

TgeneUBR5

GO:0050847

progesterone receptor signaling pathway

12011095

TgeneUBR5

GO:0070936

protein K48-linked ubiquitination

28689657


check buttonFusion gene breakpoints across HIVEP3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across UBR5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-CV-7423-11AHIVEP3chr1

42041214

-UBR5chr8

103293747

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000372584HIVEP3chr142041214-ENST00000520539UBR5chr8103293747-102166222101589252636
ENST00000372584HIVEP3chr142041214-ENST00000220959UBR5chr8103293747-94896222101589222635
ENST00000247584HIVEP3chr142041214-ENST00000520539UBR5chr8103293747-10007601380687162636
ENST00000247584HIVEP3chr142041214-ENST00000220959UBR5chr8103293747-9280601380687132635
ENST00000429157HIVEP3chr142041214-ENST00000520539UBR5chr8103293747-10007601380687162636
ENST00000429157HIVEP3chr142041214-ENST00000220959UBR5chr8103293747-9280601380687132635

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000372584ENST00000520539HIVEP3chr142041214-UBR5chr8103293747-0.0020264410.9979735
ENST00000372584ENST00000220959HIVEP3chr142041214-UBR5chr8103293747-0.0040539760.995946
ENST00000247584ENST00000520539HIVEP3chr142041214-UBR5chr8103293747-0.0016772310.9983228
ENST00000247584ENST00000220959HIVEP3chr142041214-UBR5chr8103293747-0.0033624190.9966376
ENST00000429157ENST00000520539HIVEP3chr142041214-UBR5chr8103293747-0.0016772310.9983228
ENST00000429157ENST00000220959HIVEP3chr142041214-UBR5chr8103293747-0.0033624190.9966376

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>36567_36567_1_HIVEP3-UBR5_HIVEP3_chr1_42041214_ENST00000247584_UBR5_chr8_103293747_ENST00000220959_length(amino acids)=2635AA_BP=1736
MDPEQSVKGTKKAEGSPRKRLTKGEAIQTSVSSSVPYPGSGTAATQESPAQELLAPQPFPGPSSVLREGSQEKTGQQQKPPKRPPIEASV
HISQLPQHPLTPAFMSPGKPEHLLEGSTWQLVDPMRPGPSGSFVAPGLHPQSQLLPSHASIIPPEDLPGVPKVFVPRPSQVSLKPTEEAH
KKERKPQKPGKYICQYCSRPCAKPSVLQKHIRSHTGERPYPCGPCGFSFKTKSNLYKHRKSHAHRIKAGLASGMGGEMYPHGLEMERIPG
EEFEEPTEGESTDSEEETSATSGHPAELSPRPKQPLLSSGLYSSGSHSSSHERCSLSQSSTAQSLEDPPPFVEPSSEHPLSHKPEDTHTI
KQKLALRLSERKKVIDEQAFLSPGSKGSTESGYFSRSESAEQQVSPPNTNAKSYAEIIFGKCGRIGQRTAMLTATSTQPLLPLSTEDKPS
LVPLSVPRTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLSRRSSMESPKSSLYREPLSSHSEKTKPEQSLLSLQHPPSTAPPVPLLRS
HSMPSAACTISTPHHPFRGSYSFDDHITDSEALSHSSHVFTSHPRMLKRQPAIELPLGGEYSSEEPGPSSKDTASKPSDEVEPKESELTK
KTKKGLKTKGVIYECNICGARYKKRDNYEAHKKYYCSELQIAKPISAGTHTSPEAEKSQIEHEPWSQMMHYKLGTTLELTPLRKRRKEKS
LGDEEEPPAFESTKSQFGSPGPSDAARNLPLESTKSPAEPSKSVPSLEGPTGFQPRTPKPGSGSESGKERRTTSKEISVIQHTSSFEKSD
SLEQPSGLEGEDKPLAQFPSPPPAPHGRSAHSLQPKLVRQPNIQVPEILVTEEPDRPDTEPEPPPKEPEKTEEFQWPQRSQTLAQLPAEK
LPPKKKRLRLAEMAQSSGESSFESSVPLSRSPSQESNVSLSGSSRSASFERDDHGKAEAPSPSSDMRPKPLGTHMLTVPSHHPHAREMRR
SASEQSPNVSHSAHMTETRSKSFDYGSLSLTGPSAPAPVAPPARVAPPERRKCFLVRQASLSRPPESELEVAPKGRQESEEPQPSSSKPS
AKSSLSQISSAATSHGGPPGGKGPGQDRPPLGPTVPYTEALQVFHHPVAQTPLHEKPYLPPPVSLFSFQHLVQHEPGQSPEFFSTQAMSS
LLSSPYSMPPLPPSLFQAPPLPLQPTVLHPGQLHLPQLMPHPANIPFRQPPSFLPMPYPTSSALSSGFFLPLQSQFALQLPGDVESHLPQ
IKTSLAPLATGSAGLSPSTEYSSDIRLPPVAPPASSSAPTSAPPLALPACPDTMVSLVVPVRVQTNMPSYGSAMYTTLSQILVTQSQGSS
ATVALPKFEEPPSKGTTVCGADVHEVGPGPSGLSEEQSRAFPTPYLRVPVTLPERKGTSLSSESILSLEGSSSTAGGSKRVLSPAGSLEL
TMETQQQKRVKEEEASKADEKLELVKPCSVVLTSTEDGKRPEKSHLGNQGQGRRELEMLSSLSSDPSDTKEIPPLPHPALSHGTAPGSEA
LKEYPQPSGKPHRRGLTPLSVKKEDSKEQPDLPSLAPPSSLPLSETSSRPAKSQEGTDSKKVLQFPSLHTTTNVSWCYLNYIKPNHIQHA
DRRSSVYAGWCISLYNPNLPGVSTKAALSLLRSKQKVSKETYTMATAPHPEAGRLVPSSSRKPRMTEVHLPSLVSPEGQKDLARVEKEEE
RRGEPEEDAPASQRGEPARIKIFEGGRATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQ
QTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQ
PHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHD
LAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLR
NQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTH
TSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLYPRVQAMQPAFA
SKITGMLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSSEKVQENRKRHGSSRSVVDMDLDDTDDGDDNAPL
FYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAV
FSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGE
VNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYV

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>36567_36567_2_HIVEP3-UBR5_HIVEP3_chr1_42041214_ENST00000247584_UBR5_chr8_103293747_ENST00000520539_length(amino acids)=2636AA_BP=1736
MDPEQSVKGTKKAEGSPRKRLTKGEAIQTSVSSSVPYPGSGTAATQESPAQELLAPQPFPGPSSVLREGSQEKTGQQQKPPKRPPIEASV
HISQLPQHPLTPAFMSPGKPEHLLEGSTWQLVDPMRPGPSGSFVAPGLHPQSQLLPSHASIIPPEDLPGVPKVFVPRPSQVSLKPTEEAH
KKERKPQKPGKYICQYCSRPCAKPSVLQKHIRSHTGERPYPCGPCGFSFKTKSNLYKHRKSHAHRIKAGLASGMGGEMYPHGLEMERIPG
EEFEEPTEGESTDSEEETSATSGHPAELSPRPKQPLLSSGLYSSGSHSSSHERCSLSQSSTAQSLEDPPPFVEPSSEHPLSHKPEDTHTI
KQKLALRLSERKKVIDEQAFLSPGSKGSTESGYFSRSESAEQQVSPPNTNAKSYAEIIFGKCGRIGQRTAMLTATSTQPLLPLSTEDKPS
LVPLSVPRTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLSRRSSMESPKSSLYREPLSSHSEKTKPEQSLLSLQHPPSTAPPVPLLRS
HSMPSAACTISTPHHPFRGSYSFDDHITDSEALSHSSHVFTSHPRMLKRQPAIELPLGGEYSSEEPGPSSKDTASKPSDEVEPKESELTK
KTKKGLKTKGVIYECNICGARYKKRDNYEAHKKYYCSELQIAKPISAGTHTSPEAEKSQIEHEPWSQMMHYKLGTTLELTPLRKRRKEKS
LGDEEEPPAFESTKSQFGSPGPSDAARNLPLESTKSPAEPSKSVPSLEGPTGFQPRTPKPGSGSESGKERRTTSKEISVIQHTSSFEKSD
SLEQPSGLEGEDKPLAQFPSPPPAPHGRSAHSLQPKLVRQPNIQVPEILVTEEPDRPDTEPEPPPKEPEKTEEFQWPQRSQTLAQLPAEK
LPPKKKRLRLAEMAQSSGESSFESSVPLSRSPSQESNVSLSGSSRSASFERDDHGKAEAPSPSSDMRPKPLGTHMLTVPSHHPHAREMRR
SASEQSPNVSHSAHMTETRSKSFDYGSLSLTGPSAPAPVAPPARVAPPERRKCFLVRQASLSRPPESELEVAPKGRQESEEPQPSSSKPS
AKSSLSQISSAATSHGGPPGGKGPGQDRPPLGPTVPYTEALQVFHHPVAQTPLHEKPYLPPPVSLFSFQHLVQHEPGQSPEFFSTQAMSS
LLSSPYSMPPLPPSLFQAPPLPLQPTVLHPGQLHLPQLMPHPANIPFRQPPSFLPMPYPTSSALSSGFFLPLQSQFALQLPGDVESHLPQ
IKTSLAPLATGSAGLSPSTEYSSDIRLPPVAPPASSSAPTSAPPLALPACPDTMVSLVVPVRVQTNMPSYGSAMYTTLSQILVTQSQGSS
ATVALPKFEEPPSKGTTVCGADVHEVGPGPSGLSEEQSRAFPTPYLRVPVTLPERKGTSLSSESILSLEGSSSTAGGSKRVLSPAGSLEL
TMETQQQKRVKEEEASKADEKLELVKPCSVVLTSTEDGKRPEKSHLGNQGQGRRELEMLSSLSSDPSDTKEIPPLPHPALSHGTAPGSEA
LKEYPQPSGKPHRRGLTPLSVKKEDSKEQPDLPSLAPPSSLPLSETSSRPAKSQEGTDSKKVLQFPSLHTTTNVSWCYLNYIKPNHIQHA
DRRSSVYAGWCISLYNPNLPGVSTKAALSLLRSKQKVSKETYTMATAPHPEAGRLVPSSSRKPRMTEVHLPSLVSPEGQKDLARVEKEEE
RRGEPEEDAPASQRGEPARIKIFEGGRATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQ
QTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQ
PHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHD
LAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLR
NQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTH
TSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLYPRVQAMQPAFA
SKITGMLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNAP
LFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADA
VFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCG
EVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLY

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>36567_36567_3_HIVEP3-UBR5_HIVEP3_chr1_42041214_ENST00000372584_UBR5_chr8_103293747_ENST00000220959_length(amino acids)=2635AA_BP=1736
MDPEQSVKGTKKAEGSPRKRLTKGEAIQTSVSSSVPYPGSGTAATQESPAQELLAPQPFPGPSSVLREGSQEKTGQQQKPPKRPPIEASV
HISQLPQHPLTPAFMSPGKPEHLLEGSTWQLVDPMRPGPSGSFVAPGLHPQSQLLPSHASIIPPEDLPGVPKVFVPRPSQVSLKPTEEAH
KKERKPQKPGKYICQYCSRPCAKPSVLQKHIRSHTGERPYPCGPCGFSFKTKSNLYKHRKSHAHRIKAGLASGMGGEMYPHGLEMERIPG
EEFEEPTEGESTDSEEETSATSGHPAELSPRPKQPLLSSGLYSSGSHSSSHERCSLSQSSTAQSLEDPPPFVEPSSEHPLSHKPEDTHTI
KQKLALRLSERKKVIDEQAFLSPGSKGSTESGYFSRSESAEQQVSPPNTNAKSYAEIIFGKCGRIGQRTAMLTATSTQPLLPLSTEDKPS
LVPLSVPRTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLSRRSSMESPKSSLYREPLSSHSEKTKPEQSLLSLQHPPSTAPPVPLLRS
HSMPSAACTISTPHHPFRGSYSFDDHITDSEALSHSSHVFTSHPRMLKRQPAIELPLGGEYSSEEPGPSSKDTASKPSDEVEPKESELTK
KTKKGLKTKGVIYECNICGARYKKRDNYEAHKKYYCSELQIAKPISAGTHTSPEAEKSQIEHEPWSQMMHYKLGTTLELTPLRKRRKEKS
LGDEEEPPAFESTKSQFGSPGPSDAARNLPLESTKSPAEPSKSVPSLEGPTGFQPRTPKPGSGSESGKERRTTSKEISVIQHTSSFEKSD
SLEQPSGLEGEDKPLAQFPSPPPAPHGRSAHSLQPKLVRQPNIQVPEILVTEEPDRPDTEPEPPPKEPEKTEEFQWPQRSQTLAQLPAEK
LPPKKKRLRLAEMAQSSGESSFESSVPLSRSPSQESNVSLSGSSRSASFERDDHGKAEAPSPSSDMRPKPLGTHMLTVPSHHPHAREMRR
SASEQSPNVSHSAHMTETRSKSFDYGSLSLTGPSAPAPVAPPARVAPPERRKCFLVRQASLSRPPESELEVAPKGRQESEEPQPSSSKPS
AKSSLSQISSAATSHGGPPGGKGPGQDRPPLGPTVPYTEALQVFHHPVAQTPLHEKPYLPPPVSLFSFQHLVQHEPGQSPEFFSTQAMSS
LLSSPYSMPPLPPSLFQAPPLPLQPTVLHPGQLHLPQLMPHPANIPFRQPPSFLPMPYPTSSALSSGFFLPLQSQFALQLPGDVESHLPQ
IKTSLAPLATGSAGLSPSTEYSSDIRLPPVAPPASSSAPTSAPPLALPACPDTMVSLVVPVRVQTNMPSYGSAMYTTLSQILVTQSQGSS
ATVALPKFEEPPSKGTTVCGADVHEVGPGPSGLSEEQSRAFPTPYLRVPVTLPERKGTSLSSESILSLEGSSSTAGGSKRVLSPAGSLEL
TMETQQQKRVKEEEASKADEKLELVKPCSVVLTSTEDGKRPEKSHLGNQGQGRRELEMLSSLSSDPSDTKEIPPLPHPALSHGTAPGSEA
LKEYPQPSGKPHRRGLTPLSVKKEDSKEQPDLPSLAPPSSLPLSETSSRPAKSQEGTDSKKVLQFPSLHTTTNVSWCYLNYIKPNHIQHA
DRRSSVYAGWCISLYNPNLPGVSTKAALSLLRSKQKVSKETYTMATAPHPEAGRLVPSSSRKPRMTEVHLPSLVSPEGQKDLARVEKEEE
RRGEPEEDAPASQRGEPARIKIFEGGRATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQ
QTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQ
PHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHD
LAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLR
NQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTH
TSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLYPRVQAMQPAFA
SKITGMLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSSEKVQENRKRHGSSRSVVDMDLDDTDDGDDNAPL
FYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAV
FSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGE
VNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYV

--------------------------------------------------------------

>36567_36567_4_HIVEP3-UBR5_HIVEP3_chr1_42041214_ENST00000372584_UBR5_chr8_103293747_ENST00000520539_length(amino acids)=2636AA_BP=1736
MDPEQSVKGTKKAEGSPRKRLTKGEAIQTSVSSSVPYPGSGTAATQESPAQELLAPQPFPGPSSVLREGSQEKTGQQQKPPKRPPIEASV
HISQLPQHPLTPAFMSPGKPEHLLEGSTWQLVDPMRPGPSGSFVAPGLHPQSQLLPSHASIIPPEDLPGVPKVFVPRPSQVSLKPTEEAH
KKERKPQKPGKYICQYCSRPCAKPSVLQKHIRSHTGERPYPCGPCGFSFKTKSNLYKHRKSHAHRIKAGLASGMGGEMYPHGLEMERIPG
EEFEEPTEGESTDSEEETSATSGHPAELSPRPKQPLLSSGLYSSGSHSSSHERCSLSQSSTAQSLEDPPPFVEPSSEHPLSHKPEDTHTI
KQKLALRLSERKKVIDEQAFLSPGSKGSTESGYFSRSESAEQQVSPPNTNAKSYAEIIFGKCGRIGQRTAMLTATSTQPLLPLSTEDKPS
LVPLSVPRTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLSRRSSMESPKSSLYREPLSSHSEKTKPEQSLLSLQHPPSTAPPVPLLRS
HSMPSAACTISTPHHPFRGSYSFDDHITDSEALSHSSHVFTSHPRMLKRQPAIELPLGGEYSSEEPGPSSKDTASKPSDEVEPKESELTK
KTKKGLKTKGVIYECNICGARYKKRDNYEAHKKYYCSELQIAKPISAGTHTSPEAEKSQIEHEPWSQMMHYKLGTTLELTPLRKRRKEKS
LGDEEEPPAFESTKSQFGSPGPSDAARNLPLESTKSPAEPSKSVPSLEGPTGFQPRTPKPGSGSESGKERRTTSKEISVIQHTSSFEKSD
SLEQPSGLEGEDKPLAQFPSPPPAPHGRSAHSLQPKLVRQPNIQVPEILVTEEPDRPDTEPEPPPKEPEKTEEFQWPQRSQTLAQLPAEK
LPPKKKRLRLAEMAQSSGESSFESSVPLSRSPSQESNVSLSGSSRSASFERDDHGKAEAPSPSSDMRPKPLGTHMLTVPSHHPHAREMRR
SASEQSPNVSHSAHMTETRSKSFDYGSLSLTGPSAPAPVAPPARVAPPERRKCFLVRQASLSRPPESELEVAPKGRQESEEPQPSSSKPS
AKSSLSQISSAATSHGGPPGGKGPGQDRPPLGPTVPYTEALQVFHHPVAQTPLHEKPYLPPPVSLFSFQHLVQHEPGQSPEFFSTQAMSS
LLSSPYSMPPLPPSLFQAPPLPLQPTVLHPGQLHLPQLMPHPANIPFRQPPSFLPMPYPTSSALSSGFFLPLQSQFALQLPGDVESHLPQ
IKTSLAPLATGSAGLSPSTEYSSDIRLPPVAPPASSSAPTSAPPLALPACPDTMVSLVVPVRVQTNMPSYGSAMYTTLSQILVTQSQGSS
ATVALPKFEEPPSKGTTVCGADVHEVGPGPSGLSEEQSRAFPTPYLRVPVTLPERKGTSLSSESILSLEGSSSTAGGSKRVLSPAGSLEL
TMETQQQKRVKEEEASKADEKLELVKPCSVVLTSTEDGKRPEKSHLGNQGQGRRELEMLSSLSSDPSDTKEIPPLPHPALSHGTAPGSEA
LKEYPQPSGKPHRRGLTPLSVKKEDSKEQPDLPSLAPPSSLPLSETSSRPAKSQEGTDSKKVLQFPSLHTTTNVSWCYLNYIKPNHIQHA
DRRSSVYAGWCISLYNPNLPGVSTKAALSLLRSKQKVSKETYTMATAPHPEAGRLVPSSSRKPRMTEVHLPSLVSPEGQKDLARVEKEEE
RRGEPEEDAPASQRGEPARIKIFEGGRATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQ
QTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQ
PHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHD
LAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLR
NQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTH
TSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLYPRVQAMQPAFA
SKITGMLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNAP
LFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADA
VFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCG
EVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLY

--------------------------------------------------------------

>36567_36567_5_HIVEP3-UBR5_HIVEP3_chr1_42041214_ENST00000429157_UBR5_chr8_103293747_ENST00000220959_length(amino acids)=2635AA_BP=1736
MDPEQSVKGTKKAEGSPRKRLTKGEAIQTSVSSSVPYPGSGTAATQESPAQELLAPQPFPGPSSVLREGSQEKTGQQQKPPKRPPIEASV
HISQLPQHPLTPAFMSPGKPEHLLEGSTWQLVDPMRPGPSGSFVAPGLHPQSQLLPSHASIIPPEDLPGVPKVFVPRPSQVSLKPTEEAH
KKERKPQKPGKYICQYCSRPCAKPSVLQKHIRSHTGERPYPCGPCGFSFKTKSNLYKHRKSHAHRIKAGLASGMGGEMYPHGLEMERIPG
EEFEEPTEGESTDSEEETSATSGHPAELSPRPKQPLLSSGLYSSGSHSSSHERCSLSQSSTAQSLEDPPPFVEPSSEHPLSHKPEDTHTI
KQKLALRLSERKKVIDEQAFLSPGSKGSTESGYFSRSESAEQQVSPPNTNAKSYAEIIFGKCGRIGQRTAMLTATSTQPLLPLSTEDKPS
LVPLSVPRTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLSRRSSMESPKSSLYREPLSSHSEKTKPEQSLLSLQHPPSTAPPVPLLRS
HSMPSAACTISTPHHPFRGSYSFDDHITDSEALSHSSHVFTSHPRMLKRQPAIELPLGGEYSSEEPGPSSKDTASKPSDEVEPKESELTK
KTKKGLKTKGVIYECNICGARYKKRDNYEAHKKYYCSELQIAKPISAGTHTSPEAEKSQIEHEPWSQMMHYKLGTTLELTPLRKRRKEKS
LGDEEEPPAFESTKSQFGSPGPSDAARNLPLESTKSPAEPSKSVPSLEGPTGFQPRTPKPGSGSESGKERRTTSKEISVIQHTSSFEKSD
SLEQPSGLEGEDKPLAQFPSPPPAPHGRSAHSLQPKLVRQPNIQVPEILVTEEPDRPDTEPEPPPKEPEKTEEFQWPQRSQTLAQLPAEK
LPPKKKRLRLAEMAQSSGESSFESSVPLSRSPSQESNVSLSGSSRSASFERDDHGKAEAPSPSSDMRPKPLGTHMLTVPSHHPHAREMRR
SASEQSPNVSHSAHMTETRSKSFDYGSLSLTGPSAPAPVAPPARVAPPERRKCFLVRQASLSRPPESELEVAPKGRQESEEPQPSSSKPS
AKSSLSQISSAATSHGGPPGGKGPGQDRPPLGPTVPYTEALQVFHHPVAQTPLHEKPYLPPPVSLFSFQHLVQHEPGQSPEFFSTQAMSS
LLSSPYSMPPLPPSLFQAPPLPLQPTVLHPGQLHLPQLMPHPANIPFRQPPSFLPMPYPTSSALSSGFFLPLQSQFALQLPGDVESHLPQ
IKTSLAPLATGSAGLSPSTEYSSDIRLPPVAPPASSSAPTSAPPLALPACPDTMVSLVVPVRVQTNMPSYGSAMYTTLSQILVTQSQGSS
ATVALPKFEEPPSKGTTVCGADVHEVGPGPSGLSEEQSRAFPTPYLRVPVTLPERKGTSLSSESILSLEGSSSTAGGSKRVLSPAGSLEL
TMETQQQKRVKEEEASKADEKLELVKPCSVVLTSTEDGKRPEKSHLGNQGQGRRELEMLSSLSSDPSDTKEIPPLPHPALSHGTAPGSEA
LKEYPQPSGKPHRRGLTPLSVKKEDSKEQPDLPSLAPPSSLPLSETSSRPAKSQEGTDSKKVLQFPSLHTTTNVSWCYLNYIKPNHIQHA
DRRSSVYAGWCISLYNPNLPGVSTKAALSLLRSKQKVSKETYTMATAPHPEAGRLVPSSSRKPRMTEVHLPSLVSPEGQKDLARVEKEEE
RRGEPEEDAPASQRGEPARIKIFEGGRATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQ
QTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQ
PHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHD
LAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLR
NQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTH
TSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLYPRVQAMQPAFA
SKITGMLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSSEKVQENRKRHGSSRSVVDMDLDDTDDGDDNAPL
FYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAV
FSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGE
VNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYV

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>36567_36567_6_HIVEP3-UBR5_HIVEP3_chr1_42041214_ENST00000429157_UBR5_chr8_103293747_ENST00000520539_length(amino acids)=2636AA_BP=1736
MDPEQSVKGTKKAEGSPRKRLTKGEAIQTSVSSSVPYPGSGTAATQESPAQELLAPQPFPGPSSVLREGSQEKTGQQQKPPKRPPIEASV
HISQLPQHPLTPAFMSPGKPEHLLEGSTWQLVDPMRPGPSGSFVAPGLHPQSQLLPSHASIIPPEDLPGVPKVFVPRPSQVSLKPTEEAH
KKERKPQKPGKYICQYCSRPCAKPSVLQKHIRSHTGERPYPCGPCGFSFKTKSNLYKHRKSHAHRIKAGLASGMGGEMYPHGLEMERIPG
EEFEEPTEGESTDSEEETSATSGHPAELSPRPKQPLLSSGLYSSGSHSSSHERCSLSQSSTAQSLEDPPPFVEPSSEHPLSHKPEDTHTI
KQKLALRLSERKKVIDEQAFLSPGSKGSTESGYFSRSESAEQQVSPPNTNAKSYAEIIFGKCGRIGQRTAMLTATSTQPLLPLSTEDKPS
LVPLSVPRTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLSRRSSMESPKSSLYREPLSSHSEKTKPEQSLLSLQHPPSTAPPVPLLRS
HSMPSAACTISTPHHPFRGSYSFDDHITDSEALSHSSHVFTSHPRMLKRQPAIELPLGGEYSSEEPGPSSKDTASKPSDEVEPKESELTK
KTKKGLKTKGVIYECNICGARYKKRDNYEAHKKYYCSELQIAKPISAGTHTSPEAEKSQIEHEPWSQMMHYKLGTTLELTPLRKRRKEKS
LGDEEEPPAFESTKSQFGSPGPSDAARNLPLESTKSPAEPSKSVPSLEGPTGFQPRTPKPGSGSESGKERRTTSKEISVIQHTSSFEKSD
SLEQPSGLEGEDKPLAQFPSPPPAPHGRSAHSLQPKLVRQPNIQVPEILVTEEPDRPDTEPEPPPKEPEKTEEFQWPQRSQTLAQLPAEK
LPPKKKRLRLAEMAQSSGESSFESSVPLSRSPSQESNVSLSGSSRSASFERDDHGKAEAPSPSSDMRPKPLGTHMLTVPSHHPHAREMRR
SASEQSPNVSHSAHMTETRSKSFDYGSLSLTGPSAPAPVAPPARVAPPERRKCFLVRQASLSRPPESELEVAPKGRQESEEPQPSSSKPS
AKSSLSQISSAATSHGGPPGGKGPGQDRPPLGPTVPYTEALQVFHHPVAQTPLHEKPYLPPPVSLFSFQHLVQHEPGQSPEFFSTQAMSS
LLSSPYSMPPLPPSLFQAPPLPLQPTVLHPGQLHLPQLMPHPANIPFRQPPSFLPMPYPTSSALSSGFFLPLQSQFALQLPGDVESHLPQ
IKTSLAPLATGSAGLSPSTEYSSDIRLPPVAPPASSSAPTSAPPLALPACPDTMVSLVVPVRVQTNMPSYGSAMYTTLSQILVTQSQGSS
ATVALPKFEEPPSKGTTVCGADVHEVGPGPSGLSEEQSRAFPTPYLRVPVTLPERKGTSLSSESILSLEGSSSTAGGSKRVLSPAGSLEL
TMETQQQKRVKEEEASKADEKLELVKPCSVVLTSTEDGKRPEKSHLGNQGQGRRELEMLSSLSSDPSDTKEIPPLPHPALSHGTAPGSEA
LKEYPQPSGKPHRRGLTPLSVKKEDSKEQPDLPSLAPPSSLPLSETSSRPAKSQEGTDSKKVLQFPSLHTTTNVSWCYLNYIKPNHIQHA
DRRSSVYAGWCISLYNPNLPGVSTKAALSLLRSKQKVSKETYTMATAPHPEAGRLVPSSSRKPRMTEVHLPSLVSPEGQKDLARVEKEEE
RRGEPEEDAPASQRGEPARIKIFEGGRATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQ
QTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQ
PHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHD
LAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLR
NQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTH
TSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLYPRVQAMQPAFA
SKITGMLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNAP
LFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADA
VFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCG
EVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLY

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:42041214/chr8:103293747)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HIVEP3

Q5T1R4

.
FUNCTION: Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000247584-481442_14661735.66666666666672407.0Coiled coilOntology_term=ECO:0000255
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372583-591442_14661735.66666666666672407.0Coiled coilOntology_term=ECO:0000255
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372584-481442_14661735.66666666666672406.0Coiled coilOntology_term=ECO:0000255
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000429157-481442_14661735.66666666666672406.0Coiled coilOntology_term=ECO:0000255
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000247584-48308_3341735.66666666666672407.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000247584-48378_4141735.66666666666672407.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000247584-48797_8191735.66666666666672407.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000247584-48844_8801735.66666666666672407.0Compositional biasNote=Glu/Pro-rich
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000247584-48916_9481735.66666666666672407.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372583-59308_3341735.66666666666672407.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372583-59378_4141735.66666666666672407.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372583-59797_8191735.66666666666672407.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372583-59844_8801735.66666666666672407.0Compositional biasNote=Glu/Pro-rich
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372583-59916_9481735.66666666666672407.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372584-48308_3341735.66666666666672406.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372584-48378_4141735.66666666666672406.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372584-48797_8191735.66666666666672406.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372584-48844_8801735.66666666666672406.0Compositional biasNote=Glu/Pro-rich
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372584-48916_9481735.66666666666672406.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000429157-48308_3341735.66666666666672406.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000429157-48378_4141735.66666666666672406.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000429157-48797_8191735.66666666666672406.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000429157-48844_8801735.66666666666672406.0Compositional biasNote=Glu/Pro-rich
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000429157-48916_9481735.66666666666672406.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000247584-48903_9091735.66666666666672407.0MotifNuclear localization signal
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372583-59903_9091735.66666666666672407.0MotifNuclear localization signal
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372584-48903_9091735.66666666666672406.0MotifNuclear localization signal
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000429157-48903_9091735.66666666666672406.0MotifNuclear localization signal
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000247584-48192_2421735.66666666666672407.0RegionNote=ZAS1
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000247584-48211_10741735.66666666666672407.0RegionNo DNA binding activity or transactivation activity%2C but complete prevention of TRAF-dependent NF-Kappa-B activation%3B associates with TRAF2 and JUN
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000247584-48264_2871735.66666666666672407.0RegionNote=Acidic 1
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000247584-48862_8831735.66666666666672407.0RegionNote=Acidic 2
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372583-59192_2421735.66666666666672407.0RegionNote=ZAS1
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372583-59211_10741735.66666666666672407.0RegionNo DNA binding activity or transactivation activity%2C but complete prevention of TRAF-dependent NF-Kappa-B activation%3B associates with TRAF2 and JUN
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372583-59264_2871735.66666666666672407.0RegionNote=Acidic 1
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372583-59862_8831735.66666666666672407.0RegionNote=Acidic 2
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372584-48192_2421735.66666666666672406.0RegionNote=ZAS1
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372584-48211_10741735.66666666666672406.0RegionNo DNA binding activity or transactivation activity%2C but complete prevention of TRAF-dependent NF-Kappa-B activation%3B associates with TRAF2 and JUN
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372584-48264_2871735.66666666666672406.0RegionNote=Acidic 1
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372584-48862_8831735.66666666666672406.0RegionNote=Acidic 2
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000429157-48192_2421735.66666666666672406.0RegionNote=ZAS1
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000429157-48211_10741735.66666666666672406.0RegionNo DNA binding activity or transactivation activity%2C but complete prevention of TRAF-dependent NF-Kappa-B activation%3B associates with TRAF2 and JUN
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000429157-48264_2871735.66666666666672406.0RegionNote=Acidic 1
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000429157-48862_8831735.66666666666672406.0RegionNote=Acidic 2
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000247584-48192_2141735.66666666666672407.0Zinc fingerC2H2-type 1
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000247584-48220_2421735.66666666666672407.0Zinc fingerC2H2-type 2
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000247584-48640_6701735.66666666666672407.0Zinc fingerCCHC HIVEP-type
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372583-59192_2141735.66666666666672407.0Zinc fingerC2H2-type 1
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372583-59220_2421735.66666666666672407.0Zinc fingerC2H2-type 2
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372583-59640_6701735.66666666666672407.0Zinc fingerCCHC HIVEP-type
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372584-48192_2141735.66666666666672406.0Zinc fingerC2H2-type 1
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372584-48220_2421735.66666666666672406.0Zinc fingerC2H2-type 2
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372584-48640_6701735.66666666666672406.0Zinc fingerCCHC HIVEP-type
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000429157-48192_2141735.66666666666672406.0Zinc fingerC2H2-type 1
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000429157-48220_2421735.66666666666672406.0Zinc fingerC2H2-type 2
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000429157-48640_6701735.66666666666672406.0Zinc fingerCCHC HIVEP-type
TgeneUBR5chr1:42041214chr8:103293747ENST0000052053939591986_19971898.66666666666672800.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneUBR5chr1:42041214chr8:103293747ENST0000052053939592036_20591898.66666666666672800.0Compositional biasNote=Pro-rich
TgeneUBR5chr1:42041214chr8:103293747ENST0000052053939592329_23481898.66666666666672800.0Compositional biasNote=Arg/Glu-rich (mixed charge)
TgeneUBR5chr1:42041214chr8:103293747ENST0000052053939592357_23661898.66666666666672800.0Compositional biasNote=Arg/Asp-rich (mixed charge)
TgeneUBR5chr1:42041214chr8:103293747ENST0000052053939592489_25001898.66666666666672800.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneUBR5chr1:42041214chr8:103293747ENST0000052053939592737_27571898.66666666666672800.0Compositional biasNote=Pro-rich
TgeneUBR5chr1:42041214chr8:103293747ENST0000052053939592377_24541898.66666666666672800.0DomainPABC
TgeneUBR5chr1:42041214chr8:103293747ENST0000052053939592462_27991898.66666666666672800.0DomainHECT

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000247584-481907_19361735.66666666666672407.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372583-591907_19361735.66666666666672407.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372584-481907_19361735.66666666666672406.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000429157-481907_19361735.66666666666672406.0Compositional biasNote=Ser-rich
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000247584-481754_18061735.66666666666672407.0RegionNote=ZAS2
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000247584-481817_18721735.66666666666672407.0RegionNote=Acidic 3
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000247584-482053_21481735.66666666666672407.0RegionNote=6 X 4 AA tandem repeats of S-P-X-[RK]
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372583-591754_18061735.66666666666672407.0RegionNote=ZAS2
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372583-591817_18721735.66666666666672407.0RegionNote=Acidic 3
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372583-592053_21481735.66666666666672407.0RegionNote=6 X 4 AA tandem repeats of S-P-X-[RK]
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372584-481754_18061735.66666666666672406.0RegionNote=ZAS2
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372584-481817_18721735.66666666666672406.0RegionNote=Acidic 3
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372584-482053_21481735.66666666666672406.0RegionNote=6 X 4 AA tandem repeats of S-P-X-[RK]
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000429157-481754_18061735.66666666666672406.0RegionNote=ZAS2
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000429157-481817_18721735.66666666666672406.0RegionNote=Acidic 3
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000429157-482053_21481735.66666666666672406.0RegionNote=6 X 4 AA tandem repeats of S-P-X-[RK]
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000247584-481964_19671735.66666666666672407.0RepeatNote=1
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000247584-481970_19731735.66666666666672407.0RepeatNote=2
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000247584-481993_19961735.66666666666672407.0RepeatNote=3
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000247584-481998_20011735.66666666666672407.0RepeatNote=4
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000247584-482067_20701735.66666666666672407.0RepeatNote=5
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000247584-482079_20821735.66666666666672407.0RepeatNote=6
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372583-591964_19671735.66666666666672407.0RepeatNote=1
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372583-591970_19731735.66666666666672407.0RepeatNote=2
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372583-591993_19961735.66666666666672407.0RepeatNote=3
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372583-591998_20011735.66666666666672407.0RepeatNote=4
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372583-592067_20701735.66666666666672407.0RepeatNote=5
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372583-592079_20821735.66666666666672407.0RepeatNote=6
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372584-481964_19671735.66666666666672406.0RepeatNote=1
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372584-481970_19731735.66666666666672406.0RepeatNote=2
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372584-481993_19961735.66666666666672406.0RepeatNote=3
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372584-481998_20011735.66666666666672406.0RepeatNote=4
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372584-482067_20701735.66666666666672406.0RepeatNote=5
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372584-482079_20821735.66666666666672406.0RepeatNote=6
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000429157-481964_19671735.66666666666672406.0RepeatNote=1
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000429157-481970_19731735.66666666666672406.0RepeatNote=2
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000429157-481993_19961735.66666666666672406.0RepeatNote=3
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000429157-481998_20011735.66666666666672406.0RepeatNote=4
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000429157-482067_20701735.66666666666672406.0RepeatNote=5
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000429157-482079_20821735.66666666666672406.0RepeatNote=6
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000247584-481754_17761735.66666666666672407.0Zinc fingerC2H2-type 3
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000247584-481782_18061735.66666666666672407.0Zinc fingerC2H2-type 4
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372583-591754_17761735.66666666666672407.0Zinc fingerC2H2-type 3
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372583-591782_18061735.66666666666672407.0Zinc fingerC2H2-type 4
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372584-481754_17761735.66666666666672406.0Zinc fingerC2H2-type 3
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000372584-481782_18061735.66666666666672406.0Zinc fingerC2H2-type 4
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000429157-481754_17761735.66666666666672406.0Zinc fingerC2H2-type 3
HgeneHIVEP3chr1:42041214chr8:103293747ENST00000429157-481782_18061735.66666666666672406.0Zinc fingerC2H2-type 4
TgeneUBR5chr1:42041214chr8:103293747ENST0000052053939591528_15371898.66666666666672800.0Compositional biasNote=Poly-Ser
TgeneUBR5chr1:42041214chr8:103293747ENST0000052053939591671_16811898.66666666666672800.0Compositional biasNote=Poly-Ser
TgeneUBR5chr1:42041214chr8:103293747ENST0000052053939591762_17681898.66666666666672800.0Compositional biasNote=Poly-Ala
TgeneUBR5chr1:42041214chr8:103293747ENST000005205393959940_9451898.66666666666672800.0Compositional biasNote=Poly-Glu
TgeneUBR5chr1:42041214chr8:103293747ENST000005205393959980_9851898.66666666666672800.0Compositional biasNote=Poly-Ser
TgeneUBR5chr1:42041214chr8:103293747ENST0000052053939591177_12451898.66666666666672800.0Zinc fingerUBR-type


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
HIVEP3
UBR5


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to HIVEP3-UBR5


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to HIVEP3-UBR5


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource