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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:HMGA2-PCBP2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: HMGA2-PCBP2
	FusionPDB ID: 36850
	FusionGDB2.0 ID: 36850
		Hgene	Tgene
	Gene symbol	HMGA2	PCBP2
	Gene ID	8091	5094
	Gene name	high mobility group AT-hook 2	poly(rC) binding protein 2
	Synonyms	BABL\|HMGI-C\|HMGIC\|LIPO\|STQTL9	HNRNPE2\|HNRPE2\|hnRNP-E2
	Cytomap	12q14.3	12q13.13
	Type of gene	protein-coding	protein-coding
	Description	high mobility group protein HMGI-CHMGA2/KRT121P fusionhigh-mobility group (nonhistone chromosomal) protein isoform I-C	poly(rC)-binding protein 2alpha-CP2epididymis secretory sperm binding proteinheterogeneous nuclear ribonucleoprotein E2heterogenous nuclear ribonucleoprotein E2hnRNP E2
	Modification date	20200329	20200313
	UniProtAcc	P52926	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000354636, ENST00000393577, ENST00000393578, ENST00000403681, ENST00000425208, ENST00000536545, ENST00000541363,	ENST00000359282, ENST00000359462, ENST00000437231, ENST00000439930, ENST00000447282, ENST00000455667, ENST00000541275, ENST00000546463, ENST00000548933, ENST00000549863, ENST00000552296, ENST00000552819, ENST00000603815,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	43 X 25 X 15=16125	27 X 26 X 9=6318
	# samples	43	30
	** MAII score	log2(43/16125*10)=-5.22881869049588 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(30/6318*10)=-4.39643353125099 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: HMGA2 [Title/Abstract] AND PCBP2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PCBP2(53846160)-HMGA2(66221781), # samples:3 HMGA2(66232349)-PCBP2(53856277), # samples:2
Anticipated loss of major functional domain due to fusion event.	HMGA2-PCBP2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HMGA2-PCBP2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HMGA2-PCBP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. HMGA2-PCBP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HMGA2	GO:0000122	negative regulation of transcription by RNA polymerase II	14627817
Hgene	HMGA2	GO:0002062	chondrocyte differentiation	21484705
Hgene	HMGA2	GO:0006284	base-excision repair	19465398
Hgene	HMGA2	GO:0007095	mitotic G2 DNA damage checkpoint	16061642
Hgene	HMGA2	GO:0010564	regulation of cell cycle process	14645522
Hgene	HMGA2	GO:0010628	positive regulation of gene expression	18832382
Hgene	HMGA2	GO:0031052	chromosome breakage	19549901
Hgene	HMGA2	GO:0031507	heterochromatin assembly	16901784
Hgene	HMGA2	GO:0035978	histone H2A-S139 phosphorylation	16061642
Hgene	HMGA2	GO:0035986	senescence-associated heterochromatin focus assembly	16901784
Hgene	HMGA2	GO:0035988	chondrocyte proliferation	21484705
Hgene	HMGA2	GO:0042769	DNA damage response, detection of DNA damage	19465398
Hgene	HMGA2	GO:0043065	positive regulation of apoptotic process	16061642
Hgene	HMGA2	GO:0043066	negative regulation of apoptotic process	19465398
Hgene	HMGA2	GO:0043392	negative regulation of DNA binding	14645522
Hgene	HMGA2	GO:0043922	negative regulation by host of viral transcription	17005673
Hgene	HMGA2	GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	17005673
Hgene	HMGA2	GO:0045892	negative regulation of transcription, DNA-templated	18832382
Hgene	HMGA2	GO:0045893	positive regulation of transcription, DNA-templated	15225648\|15755872\|17005673\|17324944\|17426251
Hgene	HMGA2	GO:0045944	positive regulation of transcription by RNA polymerase II	14645522\|18832382
Hgene	HMGA2	GO:0071158	positive regulation of cell cycle arrest	16061642
Hgene	HMGA2	GO:0071902	positive regulation of protein serine/threonine kinase activity	19549901
Hgene	HMGA2	GO:0090402	oncogene-induced cell senescence	16901784
Hgene	HMGA2	GO:2000648	positive regulation of stem cell proliferation	21484705
Hgene	HMGA2	GO:2000679	positive regulation of transcription regulatory region DNA binding	18832382
Hgene	HMGA2	GO:2000685	positive regulation of cellular response to X-ray	16061642
Hgene	HMGA2	GO:2001022	positive regulation of response to DNA damage stimulus	16061642\|19465398
Hgene	HMGA2	GO:2001033	negative regulation of double-strand break repair via nonhomologous end joining	19549901
Hgene	HMGA2	GO:2001038	regulation of cellular response to drug	16061642
Tgene	PCBP2	GO:0039694	viral RNA genome replication	12414943
Tgene	PCBP2	GO:0075522	IRES-dependent viral translational initiation	12414943

Fusion gene breakpoints across HMGA2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PCBP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-DX-AB2G-01A	HMGA2	chr12	66232349	-	PCBP2	chr12	53856277	+
ChimerDB4	SARC	TCGA-DX-AB2G-01A	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000403681	HMGA2	chr12	66232349	+	ENST00000359282	PCBP2	chr12	53856277	+	2265	1389	114	992	292
ENST00000403681	HMGA2	chr12	66232349	+	ENST00000603815	PCBP2	chr12	53856277	+	3689	1389	114	992	292
ENST00000403681	HMGA2	chr12	66232349	+	ENST00000437231	PCBP2	chr12	53856277	+	3561	1389	114	992	292
ENST00000403681	HMGA2	chr12	66232349	+	ENST00000447282	PCBP2	chr12	53856277	+	3599	1389	114	992	292
ENST00000403681	HMGA2	chr12	66232349	+	ENST00000549863	PCBP2	chr12	53856277	+	2165	1389	114	992	292
ENST00000403681	HMGA2	chr12	66232349	+	ENST00000359462	PCBP2	chr12	53856277	+	2363	1389	114	992	292
ENST00000403681	HMGA2	chr12	66232349	+	ENST00000546463	PCBP2	chr12	53856277	+	2215	1389	114	992	292
ENST00000403681	HMGA2	chr12	66232349	+	ENST00000552296	PCBP2	chr12	53856277	+	2143	1389	114	992	292
ENST00000403681	HMGA2	chr12	66232349	+	ENST00000552819	PCBP2	chr12	53856277	+	2223	1389	114	992	292
ENST00000403681	HMGA2	chr12	66232349	+	ENST00000455667	PCBP2	chr12	53856277	+	3562	1389	114	992	292
ENST00000403681	HMGA2	chr12	66232349	+	ENST00000439930	PCBP2	chr12	53856277	+	2146	1389	114	992	292
ENST00000403681	HMGA2	chr12	66232349	+	ENST00000548933	PCBP2	chr12	53856277	+	2058	1389	114	992	292
ENST00000403681	HMGA2	chr12	66232349	+	ENST00000541275	PCBP2	chr12	53856277	+	1907	1389	114	992	292
ENST00000541363	HMGA2	chr12	66232349	+	ENST00000359282	PCBP2	chr12	53856277	+	1498	622	373	1113	246
ENST00000541363	HMGA2	chr12	66232349	+	ENST00000603815	PCBP2	chr12	53856277	+	2922	622	618	1202	194
ENST00000541363	HMGA2	chr12	66232349	+	ENST00000437231	PCBP2	chr12	53856277	+	2794	622	373	1074	233
ENST00000541363	HMGA2	chr12	66232349	+	ENST00000447282	PCBP2	chr12	53856277	+	2832	622	618	1112	164
ENST00000541363	HMGA2	chr12	66232349	+	ENST00000549863	PCBP2	chr12	53856277	+	1398	622	490	2	163
ENST00000541363	HMGA2	chr12	66232349	+	ENST00000359462	PCBP2	chr12	53856277	+	1596	622	618	1205	195
ENST00000541363	HMGA2	chr12	66232349	+	ENST00000546463	PCBP2	chr12	53856277	+	1448	622	373	1206	277
ENST00000541363	HMGA2	chr12	66232349	+	ENST00000552296	PCBP2	chr12	53856277	+	1376	622	373	1203	276
ENST00000541363	HMGA2	chr12	66232349	+	ENST00000552819	PCBP2	chr12	53856277	+	1456	622	618	1073	151
ENST00000541363	HMGA2	chr12	66232349	+	ENST00000455667	PCBP2	chr12	53856277	+	2795	622	373	1074	233
ENST00000541363	HMGA2	chr12	66232349	+	ENST00000439930	PCBP2	chr12	53856277	+	1379	622	618	1202	194
ENST00000541363	HMGA2	chr12	66232349	+	ENST00000548933	PCBP2	chr12	53856277	+	1291	622	618	1112	164
ENST00000541363	HMGA2	chr12	66232349	+	ENST00000541275	PCBP2	chr12	53856277	+	1140	622	373	1023	216
ENST00000393577	HMGA2	chr12	66232349	+	ENST00000359282	PCBP2	chr12	53856277	+	1273	397	148	888	246
ENST00000393577	HMGA2	chr12	66232349	+	ENST00000603815	PCBP2	chr12	53856277	+	2697	397	393	977	194
ENST00000393577	HMGA2	chr12	66232349	+	ENST00000437231	PCBP2	chr12	53856277	+	2569	397	148	849	233
ENST00000393577	HMGA2	chr12	66232349	+	ENST00000447282	PCBP2	chr12	53856277	+	2607	397	393	887	164
ENST00000393577	HMGA2	chr12	66232349	+	ENST00000549863	PCBP2	chr12	53856277	+	1173	397	393	845	150
ENST00000393577	HMGA2	chr12	66232349	+	ENST00000359462	PCBP2	chr12	53856277	+	1371	397	393	980	195
ENST00000393577	HMGA2	chr12	66232349	+	ENST00000546463	PCBP2	chr12	53856277	+	1223	397	148	981	277
ENST00000393577	HMGA2	chr12	66232349	+	ENST00000552296	PCBP2	chr12	53856277	+	1151	397	148	978	276
ENST00000393577	HMGA2	chr12	66232349	+	ENST00000552819	PCBP2	chr12	53856277	+	1231	397	393	848	151
ENST00000393577	HMGA2	chr12	66232349	+	ENST00000455667	PCBP2	chr12	53856277	+	2570	397	148	849	233
ENST00000393577	HMGA2	chr12	66232349	+	ENST00000439930	PCBP2	chr12	53856277	+	1154	397	393	977	194
ENST00000393577	HMGA2	chr12	66232349	+	ENST00000548933	PCBP2	chr12	53856277	+	1066	397	393	887	164
ENST00000393577	HMGA2	chr12	66232349	+	ENST00000541275	PCBP2	chr12	53856277	+	915	397	148	798	216
ENST00000393578	HMGA2	chr12	66232349	+	ENST00000359282	PCBP2	chr12	53856277	+	1936	1060	811	1551	246
ENST00000393578	HMGA2	chr12	66232349	+	ENST00000603815	PCBP2	chr12	53856277	+	3360	1060	1	663	220
ENST00000393578	HMGA2	chr12	66232349	+	ENST00000437231	PCBP2	chr12	53856277	+	3232	1060	811	1512	233
ENST00000393578	HMGA2	chr12	66232349	+	ENST00000447282	PCBP2	chr12	53856277	+	3270	1060	1	663	220
ENST00000393578	HMGA2	chr12	66232349	+	ENST00000549863	PCBP2	chr12	53856277	+	1836	1060	1	663	220
ENST00000393578	HMGA2	chr12	66232349	+	ENST00000359462	PCBP2	chr12	53856277	+	2034	1060	1	663	220
ENST00000393578	HMGA2	chr12	66232349	+	ENST00000546463	PCBP2	chr12	53856277	+	1886	1060	811	1644	277
ENST00000393578	HMGA2	chr12	66232349	+	ENST00000552296	PCBP2	chr12	53856277	+	1814	1060	811	1641	276
ENST00000393578	HMGA2	chr12	66232349	+	ENST00000552819	PCBP2	chr12	53856277	+	1894	1060	1	663	220
ENST00000393578	HMGA2	chr12	66232349	+	ENST00000455667	PCBP2	chr12	53856277	+	3233	1060	811	1512	233
ENST00000393578	HMGA2	chr12	66232349	+	ENST00000439930	PCBP2	chr12	53856277	+	1817	1060	1	663	220
ENST00000393578	HMGA2	chr12	66232349	+	ENST00000548933	PCBP2	chr12	53856277	+	1729	1060	1	663	220
ENST00000393578	HMGA2	chr12	66232349	+	ENST00000541275	PCBP2	chr12	53856277	+	1578	1060	1	663	220
ENST00000425208	HMGA2	chr12	66232349	+	ENST00000359282	PCBP2	chr12	53856277	+	1936	1060	811	1551	246
ENST00000425208	HMGA2	chr12	66232349	+	ENST00000603815	PCBP2	chr12	53856277	+	3360	1060	1	663	220
ENST00000425208	HMGA2	chr12	66232349	+	ENST00000437231	PCBP2	chr12	53856277	+	3232	1060	811	1512	233
ENST00000425208	HMGA2	chr12	66232349	+	ENST00000447282	PCBP2	chr12	53856277	+	3270	1060	1	663	220
ENST00000425208	HMGA2	chr12	66232349	+	ENST00000549863	PCBP2	chr12	53856277	+	1836	1060	1	663	220
ENST00000425208	HMGA2	chr12	66232349	+	ENST00000359462	PCBP2	chr12	53856277	+	2034	1060	1	663	220
ENST00000425208	HMGA2	chr12	66232349	+	ENST00000546463	PCBP2	chr12	53856277	+	1886	1060	811	1644	277
ENST00000425208	HMGA2	chr12	66232349	+	ENST00000552296	PCBP2	chr12	53856277	+	1814	1060	811	1641	276
ENST00000425208	HMGA2	chr12	66232349	+	ENST00000552819	PCBP2	chr12	53856277	+	1894	1060	1	663	220
ENST00000425208	HMGA2	chr12	66232349	+	ENST00000455667	PCBP2	chr12	53856277	+	3233	1060	811	1512	233
ENST00000425208	HMGA2	chr12	66232349	+	ENST00000439930	PCBP2	chr12	53856277	+	1817	1060	1	663	220
ENST00000425208	HMGA2	chr12	66232349	+	ENST00000548933	PCBP2	chr12	53856277	+	1729	1060	1	663	220
ENST00000425208	HMGA2	chr12	66232349	+	ENST00000541275	PCBP2	chr12	53856277	+	1578	1060	1	663	220
ENST00000536545	HMGA2	chr12	66232349	+	ENST00000359282	PCBP2	chr12	53856277	+	1936	1060	811	1551	246
ENST00000536545	HMGA2	chr12	66232349	+	ENST00000603815	PCBP2	chr12	53856277	+	3360	1060	1	663	220
ENST00000536545	HMGA2	chr12	66232349	+	ENST00000437231	PCBP2	chr12	53856277	+	3232	1060	811	1512	233
ENST00000536545	HMGA2	chr12	66232349	+	ENST00000447282	PCBP2	chr12	53856277	+	3270	1060	1	663	220
ENST00000536545	HMGA2	chr12	66232349	+	ENST00000549863	PCBP2	chr12	53856277	+	1836	1060	1	663	220
ENST00000536545	HMGA2	chr12	66232349	+	ENST00000359462	PCBP2	chr12	53856277	+	2034	1060	1	663	220
ENST00000536545	HMGA2	chr12	66232349	+	ENST00000546463	PCBP2	chr12	53856277	+	1886	1060	811	1644	277
ENST00000536545	HMGA2	chr12	66232349	+	ENST00000552296	PCBP2	chr12	53856277	+	1814	1060	811	1641	276
ENST00000536545	HMGA2	chr12	66232349	+	ENST00000552819	PCBP2	chr12	53856277	+	1894	1060	1	663	220
ENST00000536545	HMGA2	chr12	66232349	+	ENST00000455667	PCBP2	chr12	53856277	+	3233	1060	811	1512	233
ENST00000536545	HMGA2	chr12	66232349	+	ENST00000439930	PCBP2	chr12	53856277	+	1817	1060	1	663	220
ENST00000536545	HMGA2	chr12	66232349	+	ENST00000548933	PCBP2	chr12	53856277	+	1729	1060	1	663	220
ENST00000536545	HMGA2	chr12	66232349	+	ENST00000541275	PCBP2	chr12	53856277	+	1578	1060	1	663	220
ENST00000354636	HMGA2	chr12	66232349	+	ENST00000359282	PCBP2	chr12	53856277	+	1936	1060	811	1551	246
ENST00000354636	HMGA2	chr12	66232349	+	ENST00000603815	PCBP2	chr12	53856277	+	3360	1060	1	663	220
ENST00000354636	HMGA2	chr12	66232349	+	ENST00000437231	PCBP2	chr12	53856277	+	3232	1060	811	1512	233
ENST00000354636	HMGA2	chr12	66232349	+	ENST00000447282	PCBP2	chr12	53856277	+	3270	1060	1	663	220
ENST00000354636	HMGA2	chr12	66232349	+	ENST00000549863	PCBP2	chr12	53856277	+	1836	1060	1	663	220
ENST00000354636	HMGA2	chr12	66232349	+	ENST00000359462	PCBP2	chr12	53856277	+	2034	1060	1	663	220
ENST00000354636	HMGA2	chr12	66232349	+	ENST00000546463	PCBP2	chr12	53856277	+	1886	1060	811	1644	277
ENST00000354636	HMGA2	chr12	66232349	+	ENST00000552296	PCBP2	chr12	53856277	+	1814	1060	811	1641	276
ENST00000354636	HMGA2	chr12	66232349	+	ENST00000552819	PCBP2	chr12	53856277	+	1894	1060	1	663	220
ENST00000354636	HMGA2	chr12	66232349	+	ENST00000455667	PCBP2	chr12	53856277	+	3233	1060	811	1512	233
ENST00000354636	HMGA2	chr12	66232349	+	ENST00000439930	PCBP2	chr12	53856277	+	1817	1060	1	663	220
ENST00000354636	HMGA2	chr12	66232349	+	ENST00000548933	PCBP2	chr12	53856277	+	1729	1060	1	663	220
ENST00000354636	HMGA2	chr12	66232349	+	ENST00000541275	PCBP2	chr12	53856277	+	1578	1060	1	663	220

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000403681	ENST00000359282	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.021823753	0.9781763
ENST00000403681	ENST00000603815	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.013375288	0.9866247
ENST00000403681	ENST00000437231	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.024217574	0.9757824
ENST00000403681	ENST00000447282	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.012424084	0.9875759
ENST00000403681	ENST00000549863	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.016805649	0.9831943
ENST00000403681	ENST00000359462	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.009409416	0.9905906
ENST00000403681	ENST00000546463	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.015794557	0.9842054
ENST00000403681	ENST00000552296	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.018848963	0.98115104
ENST00000403681	ENST00000552819	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.016251437	0.98374856
ENST00000403681	ENST00000455667	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.023041826	0.97695816
ENST00000403681	ENST00000439930	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.006524162	0.99347585
ENST00000403681	ENST00000548933	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.007261974	0.99273807
ENST00000403681	ENST00000541275	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.04489042	0.9551096
ENST00000541363	ENST00000359282	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.020494219	0.9795058
ENST00000541363	ENST00000603815	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.009024385	0.9909757
ENST00000541363	ENST00000437231	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.020223342	0.9797767
ENST00000541363	ENST00000447282	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.018881794	0.98111826
ENST00000541363	ENST00000549863	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.015455642	0.98454434
ENST00000541363	ENST00000359462	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.010495488	0.9895046
ENST00000541363	ENST00000546463	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.014284338	0.9857157
ENST00000541363	ENST00000552296	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.013374289	0.9866258
ENST00000541363	ENST00000552819	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.015033074	0.98496693
ENST00000541363	ENST00000455667	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.02003311	0.97996694
ENST00000541363	ENST00000439930	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.004565258	0.9954347
ENST00000541363	ENST00000548933	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.004472985	0.99552697
ENST00000541363	ENST00000541275	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.049124274	0.95087576
ENST00000393577	ENST00000359282	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.031380076	0.96861994
ENST00000393577	ENST00000603815	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.011020871	0.9889791
ENST00000393577	ENST00000437231	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.020229366	0.9797706
ENST00000393577	ENST00000447282	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.016027253	0.9839728
ENST00000393577	ENST00000549863	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.017037887	0.9829621
ENST00000393577	ENST00000359462	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.014211766	0.98578817
ENST00000393577	ENST00000546463	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.023651624	0.9763484
ENST00000393577	ENST00000552296	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.020648044	0.979352
ENST00000393577	ENST00000552819	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.016324831	0.9836752
ENST00000393577	ENST00000455667	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.020038258	0.97996175
ENST00000393577	ENST00000439930	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.005906968	0.994093
ENST00000393577	ENST00000548933	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.005035745	0.99496424
ENST00000393577	ENST00000541275	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.112484135	0.88751584
ENST00000393578	ENST00000359282	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.020414164	0.9795858
ENST00000393578	ENST00000603815	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.012727057	0.9872729
ENST00000393578	ENST00000437231	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.022177923	0.977822
ENST00000393578	ENST00000447282	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.012160499	0.9878395
ENST00000393578	ENST00000549863	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.007691078	0.99230886
ENST00000393578	ENST00000359462	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.006860239	0.9931398
ENST00000393578	ENST00000546463	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.0192758	0.9807242
ENST00000393578	ENST00000552296	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.021717956	0.97828203
ENST00000393578	ENST00000552819	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.007746076	0.99225396
ENST00000393578	ENST00000455667	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.02112849	0.9788715
ENST00000393578	ENST00000439930	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.004398599	0.9956014
ENST00000393578	ENST00000548933	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.003416532	0.9965835
ENST00000393578	ENST00000541275	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.045559105	0.95444095
ENST00000425208	ENST00000359282	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.020414164	0.9795858
ENST00000425208	ENST00000603815	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.012727057	0.9872729
ENST00000425208	ENST00000437231	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.022177923	0.977822
ENST00000425208	ENST00000447282	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.012160499	0.9878395
ENST00000425208	ENST00000549863	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.007691078	0.99230886
ENST00000425208	ENST00000359462	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.006860239	0.9931398
ENST00000425208	ENST00000546463	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.0192758	0.9807242
ENST00000425208	ENST00000552296	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.021717956	0.97828203
ENST00000425208	ENST00000552819	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.007746076	0.99225396
ENST00000425208	ENST00000455667	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.02112849	0.9788715
ENST00000425208	ENST00000439930	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.004398599	0.9956014
ENST00000425208	ENST00000548933	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.003416532	0.9965835
ENST00000425208	ENST00000541275	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.045559105	0.95444095
ENST00000536545	ENST00000359282	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.020414164	0.9795858
ENST00000536545	ENST00000603815	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.012727057	0.9872729
ENST00000536545	ENST00000437231	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.022177923	0.977822
ENST00000536545	ENST00000447282	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.012160499	0.9878395
ENST00000536545	ENST00000549863	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.007691078	0.99230886
ENST00000536545	ENST00000359462	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.006860239	0.9931398
ENST00000536545	ENST00000546463	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.0192758	0.9807242
ENST00000536545	ENST00000552296	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.021717956	0.97828203
ENST00000536545	ENST00000552819	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.007746076	0.99225396
ENST00000536545	ENST00000455667	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.02112849	0.9788715
ENST00000536545	ENST00000439930	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.004398599	0.9956014
ENST00000536545	ENST00000548933	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.003416532	0.9965835
ENST00000536545	ENST00000541275	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.045559105	0.95444095
ENST00000354636	ENST00000359282	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.020414164	0.9795858
ENST00000354636	ENST00000603815	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.012727057	0.9872729
ENST00000354636	ENST00000437231	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.022177923	0.977822
ENST00000354636	ENST00000447282	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.012160499	0.9878395
ENST00000354636	ENST00000549863	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.007691078	0.99230886
ENST00000354636	ENST00000359462	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.006860239	0.9931398
ENST00000354636	ENST00000546463	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.0192758	0.9807242
ENST00000354636	ENST00000552296	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.021717956	0.97828203
ENST00000354636	ENST00000552819	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.007746076	0.99225396
ENST00000354636	ENST00000455667	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.02112849	0.9788715
ENST00000354636	ENST00000439930	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.004398599	0.9956014
ENST00000354636	ENST00000548933	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.003416532	0.9965835
ENST00000354636	ENST00000541275	HMGA2	chr12	66232349	+	PCBP2	chr12	53856277	+	0.045559105	0.95444095

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>36850_36850_1_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000354636_PCBP2_chr12_53856277_ENST00000359282_length(amino acids)=246AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGIESSSPEVKGYWAGLDASAQTTSHELTIPNDLI

--------------------------------------------------------------

>36850_36850_2_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000354636_PCBP2_chr12_53856277_ENST00000359462_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_3_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000354636_PCBP2_chr12_53856277_ENST00000437231_length(amino acids)=233AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSAGLDASAQTTSHELTIPNDLIGCIIGRQGAKINE

--------------------------------------------------------------

>36850_36850_4_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000354636_PCBP2_chr12_53856277_ENST00000439930_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_5_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000354636_PCBP2_chr12_53856277_ENST00000447282_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_6_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000354636_PCBP2_chr12_53856277_ENST00000455667_length(amino acids)=233AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSAGLDASAQTTSHELTIPNDLIGCIIGRQGAKINE

--------------------------------------------------------------

>36850_36850_7_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000354636_PCBP2_chr12_53856277_ENST00000541275_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_8_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000354636_PCBP2_chr12_53856277_ENST00000546463_length(amino acids)=277AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQDRYSTGSDSASFPHTTPSMCLNPDLEGPPLEAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGIE
SSSPEVKGYWAGLDASAQTTSHELTIPNDLIGCIIGRQGAKINEIRQMSGAQIKIANPVEGSTDRQVTITGSAASISLAQYLINVRLSSE

--------------------------------------------------------------

>36850_36850_9_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000354636_PCBP2_chr12_53856277_ENST00000548933_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_10_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000354636_PCBP2_chr12_53856277_ENST00000549863_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_11_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000354636_PCBP2_chr12_53856277_ENST00000552296_length(amino acids)=276AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQDRYSTGSDSASFPHTTPSMCLNPDLEGPPLEAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGIE
SSSPEVKGYWGLDASAQTTSHELTIPNDLIGCIIGRQGAKINEIRQMSGAQIKIANPVEGSTDRQVTITGSAASISLAQYLINVRLSSET

--------------------------------------------------------------

>36850_36850_12_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000354636_PCBP2_chr12_53856277_ENST00000552819_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_13_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000354636_PCBP2_chr12_53856277_ENST00000603815_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_14_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000393577_PCBP2_chr12_53856277_ENST00000359282_length(amino acids)=246AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGIESSSPEVKGYWAGLDASAQTTSHELTIPNDLI

--------------------------------------------------------------

>36850_36850_15_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000393577_PCBP2_chr12_53856277_ENST00000359462_length(amino acids)=195AA_BP=2
MAPPKGVTIPYRPKPSSSPVIFAGGQDRYSTGSDSASFPHTTPSMCLNPDLEGPPLEAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHG
NTGFSGIESSSPEVKGYWAGLDASAQTTSHELTIPNDLIGCIIGRQGAKINEIRQMSGAQIKIANPVEGSTDRQVTITGSAASISLAQYL

--------------------------------------------------------------

>36850_36850_16_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000393577_PCBP2_chr12_53856277_ENST00000437231_length(amino acids)=233AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSAGLDASAQTTSHELTIPNDLIGCIIGRQGAKINE

--------------------------------------------------------------

>36850_36850_17_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000393577_PCBP2_chr12_53856277_ENST00000439930_length(amino acids)=194AA_BP=2
MAPPKGVTIPYRPKPSSSPVIFAGGQDRYSTGSDSASFPHTTPSMCLNPDLEGPPLEAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHG
NTGFSGIESSSPEVKGYWGLDASAQTTSHELTIPNDLIGCIIGRQGAKINEIRQMSGAQIKIANPVEGSTDRQVTITGSAASISLAQYLI

--------------------------------------------------------------

>36850_36850_18_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000393577_PCBP2_chr12_53856277_ENST00000447282_length(amino acids)=164AA_BP=2
MAPPKGVTIPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGIESSSPEVKGYWAGLDASAQTTSHE

--------------------------------------------------------------

>36850_36850_19_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000393577_PCBP2_chr12_53856277_ENST00000455667_length(amino acids)=233AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSAGLDASAQTTSHELTIPNDLIGCIIGRQGAKINE

--------------------------------------------------------------

>36850_36850_20_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000393577_PCBP2_chr12_53856277_ENST00000541275_length(amino acids)=216AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQDRYSTGSDSASFPHTTPSMCLNPDLEGPPLEAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGMD

--------------------------------------------------------------

>36850_36850_21_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000393577_PCBP2_chr12_53856277_ENST00000546463_length(amino acids)=277AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQDRYSTGSDSASFPHTTPSMCLNPDLEGPPLEAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGIE
SSSPEVKGYWAGLDASAQTTSHELTIPNDLIGCIIGRQGAKINEIRQMSGAQIKIANPVEGSTDRQVTITGSAASISLAQYLINVRLSSE

--------------------------------------------------------------

>36850_36850_22_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000393577_PCBP2_chr12_53856277_ENST00000548933_length(amino acids)=164AA_BP=2
MAPPKGVTIPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGIESSSPEVKGYWAGLDASAQTTSHE

--------------------------------------------------------------

>36850_36850_23_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000393577_PCBP2_chr12_53856277_ENST00000549863_length(amino acids)=150AA_BP=2
MAPPKGVTIPYRPKPSSSPVIFAGGQLTKLHQLAMQQSHFPMTHGNTGFSGIESSSPEVKGYWAGLDASAQTTSHELTIPNDLIGCIIGR

--------------------------------------------------------------

>36850_36850_24_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000393577_PCBP2_chr12_53856277_ENST00000552296_length(amino acids)=276AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQDRYSTGSDSASFPHTTPSMCLNPDLEGPPLEAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGIE
SSSPEVKGYWGLDASAQTTSHELTIPNDLIGCIIGRQGAKINEIRQMSGAQIKIANPVEGSTDRQVTITGSAASISLAQYLINVRLSSET

--------------------------------------------------------------

>36850_36850_25_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000393577_PCBP2_chr12_53856277_ENST00000552819_length(amino acids)=151AA_BP=2
MAPPKGVTIPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSAGLDASAQTTSHELTIPNDLIGCIIG

--------------------------------------------------------------

>36850_36850_26_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000393577_PCBP2_chr12_53856277_ENST00000603815_length(amino acids)=194AA_BP=2
MAPPKGVTIPYRPKPSSSPVIFAGGQDRYSTGSDSASFPHTTPSMCLNPDLEGPPLEAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHG
NTGFSGIESSSPEVKGYWGLDASAQTTSHELTIPNDLIGCIIGRQGAKINEIRQMSGAQIKIANPVEGSTDRQVTITGSAASISLAQYLI

--------------------------------------------------------------

>36850_36850_27_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000393578_PCBP2_chr12_53856277_ENST00000359282_length(amino acids)=246AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGIESSSPEVKGYWAGLDASAQTTSHELTIPNDLI

--------------------------------------------------------------

>36850_36850_28_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000393578_PCBP2_chr12_53856277_ENST00000359462_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_29_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000393578_PCBP2_chr12_53856277_ENST00000437231_length(amino acids)=233AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSAGLDASAQTTSHELTIPNDLIGCIIGRQGAKINE

--------------------------------------------------------------

>36850_36850_30_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000393578_PCBP2_chr12_53856277_ENST00000439930_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_31_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000393578_PCBP2_chr12_53856277_ENST00000447282_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_32_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000393578_PCBP2_chr12_53856277_ENST00000455667_length(amino acids)=233AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSAGLDASAQTTSHELTIPNDLIGCIIGRQGAKINE

--------------------------------------------------------------

>36850_36850_33_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000393578_PCBP2_chr12_53856277_ENST00000541275_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_34_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000393578_PCBP2_chr12_53856277_ENST00000546463_length(amino acids)=277AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQDRYSTGSDSASFPHTTPSMCLNPDLEGPPLEAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGIE
SSSPEVKGYWAGLDASAQTTSHELTIPNDLIGCIIGRQGAKINEIRQMSGAQIKIANPVEGSTDRQVTITGSAASISLAQYLINVRLSSE

--------------------------------------------------------------

>36850_36850_35_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000393578_PCBP2_chr12_53856277_ENST00000548933_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_36_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000393578_PCBP2_chr12_53856277_ENST00000549863_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_37_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000393578_PCBP2_chr12_53856277_ENST00000552296_length(amino acids)=276AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQDRYSTGSDSASFPHTTPSMCLNPDLEGPPLEAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGIE
SSSPEVKGYWGLDASAQTTSHELTIPNDLIGCIIGRQGAKINEIRQMSGAQIKIANPVEGSTDRQVTITGSAASISLAQYLINVRLSSET

--------------------------------------------------------------

>36850_36850_38_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000393578_PCBP2_chr12_53856277_ENST00000552819_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_39_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000393578_PCBP2_chr12_53856277_ENST00000603815_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_40_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000403681_PCBP2_chr12_53856277_ENST00000359282_length(amino acids)=292AA_BP=
MPLASSQAPWLGGPPGLPPPHTFLPAQPPPLYPPTIRGGHSPHHHPLPKRKRVHAHTPHTLTLTHTHTHSSHLNLGAGTQKTSSPGSARL
VQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLSLSLSLSLSLSLSLAGWGE
EEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPPAPTHRRRRHRQRLLLSSS

--------------------------------------------------------------

>36850_36850_41_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000403681_PCBP2_chr12_53856277_ENST00000359462_length(amino acids)=292AA_BP=
MPLASSQAPWLGGPPGLPPPHTFLPAQPPPLYPPTIRGGHSPHHHPLPKRKRVHAHTPHTLTLTHTHTHSSHLNLGAGTQKTSSPGSARL
VQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLSLSLSLSLSLSLSLAGWGE
EEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPPAPTHRRRRHRQRLLLSSS

--------------------------------------------------------------

>36850_36850_42_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000403681_PCBP2_chr12_53856277_ENST00000437231_length(amino acids)=292AA_BP=
MPLASSQAPWLGGPPGLPPPHTFLPAQPPPLYPPTIRGGHSPHHHPLPKRKRVHAHTPHTLTLTHTHTHSSHLNLGAGTQKTSSPGSARL
VQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLSLSLSLSLSLSLSLAGWGE
EEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPPAPTHRRRRHRQRLLLSSS

--------------------------------------------------------------

>36850_36850_43_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000403681_PCBP2_chr12_53856277_ENST00000439930_length(amino acids)=292AA_BP=
MPLASSQAPWLGGPPGLPPPHTFLPAQPPPLYPPTIRGGHSPHHHPLPKRKRVHAHTPHTLTLTHTHTHSSHLNLGAGTQKTSSPGSARL
VQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLSLSLSLSLSLSLSLAGWGE
EEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPPAPTHRRRRHRQRLLLSSS

--------------------------------------------------------------

>36850_36850_44_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000403681_PCBP2_chr12_53856277_ENST00000447282_length(amino acids)=292AA_BP=
MPLASSQAPWLGGPPGLPPPHTFLPAQPPPLYPPTIRGGHSPHHHPLPKRKRVHAHTPHTLTLTHTHTHSSHLNLGAGTQKTSSPGSARL
VQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLSLSLSLSLSLSLSLAGWGE
EEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPPAPTHRRRRHRQRLLLSSS

--------------------------------------------------------------

>36850_36850_45_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000403681_PCBP2_chr12_53856277_ENST00000455667_length(amino acids)=292AA_BP=
MPLASSQAPWLGGPPGLPPPHTFLPAQPPPLYPPTIRGGHSPHHHPLPKRKRVHAHTPHTLTLTHTHTHSSHLNLGAGTQKTSSPGSARL
VQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLSLSLSLSLSLSLSLAGWGE
EEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPPAPTHRRRRHRQRLLLSSS

--------------------------------------------------------------

>36850_36850_46_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000403681_PCBP2_chr12_53856277_ENST00000541275_length(amino acids)=292AA_BP=
MPLASSQAPWLGGPPGLPPPHTFLPAQPPPLYPPTIRGGHSPHHHPLPKRKRVHAHTPHTLTLTHTHTHSSHLNLGAGTQKTSSPGSARL
VQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLSLSLSLSLSLSLSLAGWGE
EEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPPAPTHRRRRHRQRLLLSSS

--------------------------------------------------------------

>36850_36850_47_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000403681_PCBP2_chr12_53856277_ENST00000546463_length(amino acids)=292AA_BP=
MPLASSQAPWLGGPPGLPPPHTFLPAQPPPLYPPTIRGGHSPHHHPLPKRKRVHAHTPHTLTLTHTHTHSSHLNLGAGTQKTSSPGSARL
VQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLSLSLSLSLSLSLSLAGWGE
EEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPPAPTHRRRRHRQRLLLSSS

--------------------------------------------------------------

>36850_36850_48_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000403681_PCBP2_chr12_53856277_ENST00000548933_length(amino acids)=292AA_BP=
MPLASSQAPWLGGPPGLPPPHTFLPAQPPPLYPPTIRGGHSPHHHPLPKRKRVHAHTPHTLTLTHTHTHSSHLNLGAGTQKTSSPGSARL
VQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLSLSLSLSLSLSLSLAGWGE
EEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPPAPTHRRRRHRQRLLLSSS

--------------------------------------------------------------

>36850_36850_49_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000403681_PCBP2_chr12_53856277_ENST00000549863_length(amino acids)=292AA_BP=
MPLASSQAPWLGGPPGLPPPHTFLPAQPPPLYPPTIRGGHSPHHHPLPKRKRVHAHTPHTLTLTHTHTHSSHLNLGAGTQKTSSPGSARL
VQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLSLSLSLSLSLSLSLAGWGE
EEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPPAPTHRRRRHRQRLLLSSS

--------------------------------------------------------------

>36850_36850_50_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000403681_PCBP2_chr12_53856277_ENST00000552296_length(amino acids)=292AA_BP=
MPLASSQAPWLGGPPGLPPPHTFLPAQPPPLYPPTIRGGHSPHHHPLPKRKRVHAHTPHTLTLTHTHTHSSHLNLGAGTQKTSSPGSARL
VQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLSLSLSLSLSLSLSLAGWGE
EEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPPAPTHRRRRHRQRLLLSSS

--------------------------------------------------------------

>36850_36850_51_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000403681_PCBP2_chr12_53856277_ENST00000552819_length(amino acids)=292AA_BP=
MPLASSQAPWLGGPPGLPPPHTFLPAQPPPLYPPTIRGGHSPHHHPLPKRKRVHAHTPHTLTLTHTHTHSSHLNLGAGTQKTSSPGSARL
VQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLSLSLSLSLSLSLSLAGWGE
EEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPPAPTHRRRRHRQRLLLSSS

--------------------------------------------------------------

>36850_36850_52_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000403681_PCBP2_chr12_53856277_ENST00000603815_length(amino acids)=292AA_BP=
MPLASSQAPWLGGPPGLPPPHTFLPAQPPPLYPPTIRGGHSPHHHPLPKRKRVHAHTPHTLTLTHTHTHSSHLNLGAGTQKTSSPGSARL
VQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLSLSLSLSLSLSLSLAGWGE
EEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPPAPTHRRRRHRQRLLLSSS

--------------------------------------------------------------

>36850_36850_53_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000425208_PCBP2_chr12_53856277_ENST00000359282_length(amino acids)=246AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGIESSSPEVKGYWAGLDASAQTTSHELTIPNDLI

--------------------------------------------------------------

>36850_36850_54_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000425208_PCBP2_chr12_53856277_ENST00000359462_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_55_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000425208_PCBP2_chr12_53856277_ENST00000437231_length(amino acids)=233AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSAGLDASAQTTSHELTIPNDLIGCIIGRQGAKINE

--------------------------------------------------------------

>36850_36850_56_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000425208_PCBP2_chr12_53856277_ENST00000439930_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_57_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000425208_PCBP2_chr12_53856277_ENST00000447282_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_58_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000425208_PCBP2_chr12_53856277_ENST00000455667_length(amino acids)=233AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSAGLDASAQTTSHELTIPNDLIGCIIGRQGAKINE

--------------------------------------------------------------

>36850_36850_59_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000425208_PCBP2_chr12_53856277_ENST00000541275_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_60_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000425208_PCBP2_chr12_53856277_ENST00000546463_length(amino acids)=277AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQDRYSTGSDSASFPHTTPSMCLNPDLEGPPLEAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGIE
SSSPEVKGYWAGLDASAQTTSHELTIPNDLIGCIIGRQGAKINEIRQMSGAQIKIANPVEGSTDRQVTITGSAASISLAQYLINVRLSSE

--------------------------------------------------------------

>36850_36850_61_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000425208_PCBP2_chr12_53856277_ENST00000548933_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_62_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000425208_PCBP2_chr12_53856277_ENST00000549863_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_63_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000425208_PCBP2_chr12_53856277_ENST00000552296_length(amino acids)=276AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQDRYSTGSDSASFPHTTPSMCLNPDLEGPPLEAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGIE
SSSPEVKGYWGLDASAQTTSHELTIPNDLIGCIIGRQGAKINEIRQMSGAQIKIANPVEGSTDRQVTITGSAASISLAQYLINVRLSSET

--------------------------------------------------------------

>36850_36850_64_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000425208_PCBP2_chr12_53856277_ENST00000552819_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_65_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000425208_PCBP2_chr12_53856277_ENST00000603815_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_66_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000536545_PCBP2_chr12_53856277_ENST00000359282_length(amino acids)=246AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGIESSSPEVKGYWAGLDASAQTTSHELTIPNDLI

--------------------------------------------------------------

>36850_36850_67_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000536545_PCBP2_chr12_53856277_ENST00000359462_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_68_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000536545_PCBP2_chr12_53856277_ENST00000437231_length(amino acids)=233AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSAGLDASAQTTSHELTIPNDLIGCIIGRQGAKINE

--------------------------------------------------------------

>36850_36850_69_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000536545_PCBP2_chr12_53856277_ENST00000439930_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_70_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000536545_PCBP2_chr12_53856277_ENST00000447282_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_71_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000536545_PCBP2_chr12_53856277_ENST00000455667_length(amino acids)=233AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSAGLDASAQTTSHELTIPNDLIGCIIGRQGAKINE

--------------------------------------------------------------

>36850_36850_72_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000536545_PCBP2_chr12_53856277_ENST00000541275_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_73_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000536545_PCBP2_chr12_53856277_ENST00000546463_length(amino acids)=277AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQDRYSTGSDSASFPHTTPSMCLNPDLEGPPLEAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGIE
SSSPEVKGYWAGLDASAQTTSHELTIPNDLIGCIIGRQGAKINEIRQMSGAQIKIANPVEGSTDRQVTITGSAASISLAQYLINVRLSSE

--------------------------------------------------------------

>36850_36850_74_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000536545_PCBP2_chr12_53856277_ENST00000548933_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_75_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000536545_PCBP2_chr12_53856277_ENST00000549863_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_76_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000536545_PCBP2_chr12_53856277_ENST00000552296_length(amino acids)=276AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQDRYSTGSDSASFPHTTPSMCLNPDLEGPPLEAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGIE
SSSPEVKGYWGLDASAQTTSHELTIPNDLIGCIIGRQGAKINEIRQMSGAQIKIANPVEGSTDRQVTITGSAASISLAQYLINVRLSSET

--------------------------------------------------------------

>36850_36850_77_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000536545_PCBP2_chr12_53856277_ENST00000552819_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_78_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000536545_PCBP2_chr12_53856277_ENST00000603815_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36850_36850_79_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000541363_PCBP2_chr12_53856277_ENST00000359282_length(amino acids)=246AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGIESSSPEVKGYWAGLDASAQTTSHELTIPNDLI

--------------------------------------------------------------

>36850_36850_80_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000541363_PCBP2_chr12_53856277_ENST00000359462_length(amino acids)=195AA_BP=2
MAPPKGVTIPYRPKPSSSPVIFAGGQDRYSTGSDSASFPHTTPSMCLNPDLEGPPLEAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHG
NTGFSGIESSSPEVKGYWAGLDASAQTTSHELTIPNDLIGCIIGRQGAKINEIRQMSGAQIKIANPVEGSTDRQVTITGSAASISLAQYL

--------------------------------------------------------------

>36850_36850_81_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000541363_PCBP2_chr12_53856277_ENST00000437231_length(amino acids)=233AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSAGLDASAQTTSHELTIPNDLIGCIIGRQGAKINE

--------------------------------------------------------------

>36850_36850_82_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000541363_PCBP2_chr12_53856277_ENST00000439930_length(amino acids)=194AA_BP=2
MAPPKGVTIPYRPKPSSSPVIFAGGQDRYSTGSDSASFPHTTPSMCLNPDLEGPPLEAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHG
NTGFSGIESSSPEVKGYWGLDASAQTTSHELTIPNDLIGCIIGRQGAKINEIRQMSGAQIKIANPVEGSTDRQVTITGSAASISLAQYLI

--------------------------------------------------------------

>36850_36850_83_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000541363_PCBP2_chr12_53856277_ENST00000447282_length(amino acids)=164AA_BP=2
MAPPKGVTIPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGIESSSPEVKGYWAGLDASAQTTSHE

--------------------------------------------------------------

>36850_36850_84_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000541363_PCBP2_chr12_53856277_ENST00000455667_length(amino acids)=233AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSAGLDASAQTTSHELTIPNDLIGCIIGRQGAKINE

--------------------------------------------------------------

>36850_36850_85_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000541363_PCBP2_chr12_53856277_ENST00000541275_length(amino acids)=216AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQDRYSTGSDSASFPHTTPSMCLNPDLEGPPLEAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGMD

--------------------------------------------------------------

>36850_36850_86_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000541363_PCBP2_chr12_53856277_ENST00000546463_length(amino acids)=277AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQDRYSTGSDSASFPHTTPSMCLNPDLEGPPLEAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGIE
SSSPEVKGYWAGLDASAQTTSHELTIPNDLIGCIIGRQGAKINEIRQMSGAQIKIANPVEGSTDRQVTITGSAASISLAQYLINVRLSSE

--------------------------------------------------------------

>36850_36850_87_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000541363_PCBP2_chr12_53856277_ENST00000548933_length(amino acids)=164AA_BP=2
MAPPKGVTIPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGIESSSPEVKGYWAGLDASAQTTSHE

--------------------------------------------------------------

>36850_36850_88_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000541363_PCBP2_chr12_53856277_ENST00000549863_length(amino acids)=163AA_BP=
MVLAAASWGGRVLSSEALGRQVVPGLKWTAAPRPHRVRSSCLPPPLPPLQPLRLDRPGAAQHLSGDEVIGLGTPAGRARAGGLRGLLLLR

--------------------------------------------------------------

>36850_36850_89_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000541363_PCBP2_chr12_53856277_ENST00000552296_length(amino acids)=276AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWSPPKGVT
IPYRPKPSSSPVIFAGGQDRYSTGSDSASFPHTTPSMCLNPDLEGPPLEAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGIE
SSSPEVKGYWGLDASAQTTSHELTIPNDLIGCIIGRQGAKINEIRQMSGAQIKIANPVEGSTDRQVTITGSAASISLAQYLINVRLSSET

--------------------------------------------------------------

>36850_36850_90_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000541363_PCBP2_chr12_53856277_ENST00000552819_length(amino acids)=151AA_BP=2
MAPPKGVTIPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSAGLDASAQTTSHELTIPNDLIGCIIG

--------------------------------------------------------------

>36850_36850_91_HMGA2-PCBP2_HMGA2_chr12_66232349_ENST00000541363_PCBP2_chr12_53856277_ENST00000603815_length(amino acids)=194AA_BP=2
MAPPKGVTIPYRPKPSSSPVIFAGGQDRYSTGSDSASFPHTTPSMCLNPDLEGPPLEAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHG
NTGFSGIESSSPEVKGYWGLDASAQTTSHELTIPNDLIGCIIGRQGAKINEIRQMSGAQIKIANPVEGSTDRQVTITGSAASISLAQYLI

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:53846160/chr12:66221781)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HMGA2 P52926	.
FUNCTION: Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner (PubMed:28796236). {ECO:0000250\|UniProtKB:P52927, ECO:0000269\|PubMed:14645522, ECO:0000269\|PubMed:28796236}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HMGA2

chr12:66232349

chr12:53856277

ENST00000354636

24_34

83.0

107.0

DNA binding

Note=A.T hook 1

Hgene

HMGA2

chr12:66232349

chr12:53856277

ENST00000354636

44_54

83.0

107.0

DNA binding

Note=A.T hook 2

Hgene

HMGA2

chr12:66232349

chr12:53856277

ENST00000354636

71_82

83.0

107.0

DNA binding

Note=A.T hook 3

Hgene

HMGA2

chr12:66232349

chr12:53856277

ENST00000393578

24_34

83.0

91.0

DNA binding

Note=A.T hook 1

Hgene

HMGA2

chr12:66232349

chr12:53856277

ENST00000393578

44_54

83.0

91.0

DNA binding

Note=A.T hook 2

Hgene

HMGA2

chr12:66232349

chr12:53856277

ENST00000393578

71_82

83.0

91.0

DNA binding

Note=A.T hook 3

Hgene

HMGA2

chr12:66232349

chr12:53856277

ENST00000403681

24_34

83.0

110.0

DNA binding

Note=A.T hook 1

Hgene

HMGA2

chr12:66232349

chr12:53856277

ENST00000403681

44_54

83.0

110.0

DNA binding

Note=A.T hook 2

Hgene

HMGA2

chr12:66232349

chr12:53856277

ENST00000403681

71_82

83.0

110.0

DNA binding

Note=A.T hook 3

Hgene

HMGA2

chr12:66232349

chr12:53856277

ENST00000425208

24_34

83.0

93.0

DNA binding

Note=A.T hook 1

Hgene

HMGA2

chr12:66232349

chr12:53856277

ENST00000425208

44_54

83.0

93.0

DNA binding

Note=A.T hook 2

Hgene

HMGA2

chr12:66232349

chr12:53856277

ENST00000425208

71_82

83.0

93.0

DNA binding

Note=A.T hook 3

Tgene

PCBP2

chr12:66232349

chr12:53856277

ENST00000359282

287_351

168.0

332.0

Domain

KH 3

Tgene

PCBP2

chr12:66232349

chr12:53856277

ENST00000359462

13_75

367.0

Domain

KH 1

Tgene

PCBP2

chr12:66232349

chr12:53856277

ENST00000359462

287_351

367.0

Domain

KH 3

Tgene

PCBP2

chr12:66232349

chr12:53856277

ENST00000359462

97_162

367.0

Domain

KH 2

Tgene

PCBP2

chr12:66232349

chr12:53856277

ENST00000439930

13_75

366.0

Domain

KH 1

Tgene

PCBP2

chr12:66232349

chr12:53856277

ENST00000439930

287_351

366.0

Domain

KH 3

Tgene

PCBP2

chr12:66232349

chr12:53856277

ENST00000439930

97_162

366.0

Domain

KH 2

Tgene

PCBP2

chr12:66232349

chr12:53856277

ENST00000447282

13_75

336.0

Domain

KH 1

Tgene

PCBP2

chr12:66232349

chr12:53856277

ENST00000447282

287_351

336.0

Domain

KH 3

Tgene

PCBP2

chr12:66232349

chr12:53856277

ENST00000447282

97_162

336.0

Domain

KH 2

Tgene

PCBP2

chr12:66232349

chr12:53856277

ENST00000546463

287_351

168.0

363.0

Domain

KH 3

Tgene

PCBP2

chr12:66232349

chr12:53856277

ENST00000548933

13_75

336.0

Domain

KH 1

Tgene

PCBP2

chr12:66232349

chr12:53856277

ENST00000548933

287_351

336.0

Domain

KH 3

Tgene

PCBP2

chr12:66232349

chr12:53856277

ENST00000548933

97_162

336.0

Domain

KH 2

Tgene

PCBP2

chr12:66232349

chr12:53856277

ENST00000552296

287_351

168.0

362.0

Domain

KH 3

Tgene

PCBP2

chr12:66232349

chr12:53856277

ENST00000603815

13_75

366.0

Domain

KH 1

Tgene

PCBP2

chr12:66232349

chr12:53856277

ENST00000603815

287_351

366.0

Domain

KH 3

Tgene

PCBP2

chr12:66232349

chr12:53856277

ENST00000603815

97_162

366.0

Domain

KH 2

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PCBP2

chr12:66232349

chr12:53856277

ENST00000359282

13_75

168.0

332.0

Domain

KH 1

Tgene

PCBP2

chr12:66232349

chr12:53856277

ENST00000359282

97_162

168.0

332.0

Domain

KH 2

Tgene

PCBP2

chr12:66232349

chr12:53856277

ENST00000546463

13_75

168.0

363.0

Domain

KH 1

Tgene

PCBP2

chr12:66232349

chr12:53856277

ENST00000546463

97_162

168.0

363.0

Domain

KH 2

Tgene

PCBP2

chr12:66232349

chr12:53856277

ENST00000552296

13_75

168.0

362.0

Domain

KH 1

Tgene

PCBP2

chr12:66232349

chr12:53856277

ENST00000552296

97_162

168.0

362.0

Domain

KH 2

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

HMGA2

RELA, NFKB1, PIAS3, RB1, PRMT6, NPM1, SMAD1, SMAD5, SMAD9, PRKCA, HDGF, PTBP1, APEX1, SYNCRIP, XRCC6, PSIP1, PA2G4, PCBP2, E4F1, OBSL1, HIST1H3A, CREB1, NFATC1, PCGF1, POU5F1, DLST, EZH2, SUZ12, MYC, TP53, MDM2, CSK, VRK1, HIST1H1B, PRKAG2, DUX4, DUX4L9, SYDE1, ARHGAP21, ARHGAP39, Plekhg5, ZNF263, MAFB, KAT2B, HIST1H2BG, LMNB1, NDUFAF7, CSNK2A1, LIG3, SUPT16H, VRK3, SP2, C1QBP, PARP2, TOP3A, CSNK2A2, XPC, RANBP17, PARP1, SUPV3L1, HIST2H2AC, HIST2H3PS2, KPNA4, USP7,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
HMGA2
PCBP2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to HMGA2-PCBP2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to HMGA2-PCBP2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	HMGA2	C1519176	Salivary Gland Pleomorphic Adenoma	2	ORPHANET
Hgene	HMGA2	C0005612	Birth Weight	1	CTD_human
Hgene	HMGA2	C0006826	Malignant Neoplasms	1	CTD_human
Hgene	HMGA2	C0027626	Neoplasm Invasiveness	1	CTD_human
Hgene	HMGA2	C0027651	Neoplasms	1	CTD_human
Hgene	HMGA2	C0086692	Benign Neoplasm	1	CTD_human
Hgene	HMGA2	C0175693	Russell-Silver syndrome	1	GENOMICS_ENGLAND
Hgene	HMGA2	C0473935	Radiolabeled somatostatin analog study	1	GENOMICS_ENGLAND
Hgene	HMGA2	C0796160	MENTAL RETARDATION, X-LINKED, SNYDER-ROBINSON TYPE	1	GENOMICS_ENGLAND
Hgene	HMGA2	C1096309	Myolipoma	1	GENOMICS_ENGLAND
Hgene	HMGA2	C4305140	12q14 microdeletion syndrome	1	ORPHANET