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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:HMGA2-TAX1BP1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: HMGA2-TAX1BP1
	FusionPDB ID: 36858
	FusionGDB2.0 ID: 36858
		Hgene	Tgene
	Gene symbol	HMGA2	TAX1BP1
	Gene ID	8091	8887
	Gene name	high mobility group AT-hook 2	Tax1 binding protein 1
	Synonyms	BABL\|HMGI-C\|HMGIC\|LIPO\|STQTL9	CALCOCO3\|T6BP\|TXBP151
	Cytomap	12q14.3	7p15.2
	Type of gene	protein-coding	protein-coding
	Description	high mobility group protein HMGI-CHMGA2/KRT121P fusionhigh-mobility group (nonhistone chromosomal) protein isoform I-C	tax1-binding protein 1TRAF6-binding proteinTax1 (human T-cell leukemia virus type I) binding protein 1
	Modification date	20200329	20200327
	UniProtAcc	P52926	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000354636, ENST00000393577, ENST00000393578, ENST00000403681, ENST00000425208, ENST00000536545, ENST00000541363,	ENST00000494033, ENST00000265393, ENST00000396319, ENST00000409980, ENST00000433216, ENST00000543117,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	43 X 25 X 15=16125	22 X 14 X 9=2772
	# samples	43	26
	** MAII score	log2(43/16125*10)=-5.22881869049588 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(26/2772*10)=-3.41434372910876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: HMGA2 [Title/Abstract] AND TAX1BP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	HMGA2(66232349)-TAX1BP1(27824782), # samples:1
Anticipated loss of major functional domain due to fusion event.	HMGA2-TAX1BP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HMGA2-TAX1BP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HMGA2	GO:0000122	negative regulation of transcription by RNA polymerase II	14627817
Hgene	HMGA2	GO:0002062	chondrocyte differentiation	21484705
Hgene	HMGA2	GO:0006284	base-excision repair	19465398
Hgene	HMGA2	GO:0007095	mitotic G2 DNA damage checkpoint	16061642
Hgene	HMGA2	GO:0010564	regulation of cell cycle process	14645522
Hgene	HMGA2	GO:0010628	positive regulation of gene expression	18832382
Hgene	HMGA2	GO:0031052	chromosome breakage	19549901
Hgene	HMGA2	GO:0031507	heterochromatin assembly	16901784
Hgene	HMGA2	GO:0035978	histone H2A-S139 phosphorylation	16061642
Hgene	HMGA2	GO:0035986	senescence-associated heterochromatin focus assembly	16901784
Hgene	HMGA2	GO:0035988	chondrocyte proliferation	21484705
Hgene	HMGA2	GO:0042769	DNA damage response, detection of DNA damage	19465398
Hgene	HMGA2	GO:0043065	positive regulation of apoptotic process	16061642
Hgene	HMGA2	GO:0043066	negative regulation of apoptotic process	19465398
Hgene	HMGA2	GO:0043392	negative regulation of DNA binding	14645522
Hgene	HMGA2	GO:0043922	negative regulation by host of viral transcription	17005673
Hgene	HMGA2	GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	17005673
Hgene	HMGA2	GO:0045892	negative regulation of transcription, DNA-templated	18832382
Hgene	HMGA2	GO:0045893	positive regulation of transcription, DNA-templated	15225648\|15755872\|17005673\|17324944\|17426251
Hgene	HMGA2	GO:0045944	positive regulation of transcription by RNA polymerase II	14645522\|18832382
Hgene	HMGA2	GO:0071158	positive regulation of cell cycle arrest	16061642
Hgene	HMGA2	GO:0071902	positive regulation of protein serine/threonine kinase activity	19549901
Hgene	HMGA2	GO:0090402	oncogene-induced cell senescence	16901784
Hgene	HMGA2	GO:2000648	positive regulation of stem cell proliferation	21484705
Hgene	HMGA2	GO:2000679	positive regulation of transcription regulatory region DNA binding	18832382
Hgene	HMGA2	GO:2000685	positive regulation of cellular response to X-ray	16061642
Hgene	HMGA2	GO:2001022	positive regulation of response to DNA damage stimulus	16061642\|19465398
Hgene	HMGA2	GO:2001033	negative regulation of double-strand break repair via nonhomologous end joining	19549901
Hgene	HMGA2	GO:2001038	regulation of cellular response to drug	16061642

Fusion gene breakpoints across HMGA2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TAX1BP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-DU-A5TY	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000403681	HMGA2	chr12	66232349	+	ENST00000543117	TAX1BP1	chr7	27824782	+	3285	1389	1140	3020	626
ENST00000403681	HMGA2	chr12	66232349	+	ENST00000265393	TAX1BP1	chr7	27824782	+	3073	1389	1140	3020	626
ENST00000403681	HMGA2	chr12	66232349	+	ENST00000409980	TAX1BP1	chr7	27824782	+	3271	1389	1140	3218	692
ENST00000403681	HMGA2	chr12	66232349	+	ENST00000433216	TAX1BP1	chr7	27824782	+	3056	1389	1140	3020	626
ENST00000403681	HMGA2	chr12	66232349	+	ENST00000396319	TAX1BP1	chr7	27824782	+	3579	1389	1140	3146	668
ENST00000541363	HMGA2	chr12	66232349	+	ENST00000543117	TAX1BP1	chr7	27824782	+	2518	622	373	2253	626
ENST00000541363	HMGA2	chr12	66232349	+	ENST00000265393	TAX1BP1	chr7	27824782	+	2306	622	373	2253	626
ENST00000541363	HMGA2	chr12	66232349	+	ENST00000409980	TAX1BP1	chr7	27824782	+	2504	622	373	2451	692
ENST00000541363	HMGA2	chr12	66232349	+	ENST00000433216	TAX1BP1	chr7	27824782	+	2289	622	373	2253	626
ENST00000541363	HMGA2	chr12	66232349	+	ENST00000396319	TAX1BP1	chr7	27824782	+	2812	622	373	2379	668
ENST00000393577	HMGA2	chr12	66232349	+	ENST00000543117	TAX1BP1	chr7	27824782	+	2293	397	148	2028	626
ENST00000393577	HMGA2	chr12	66232349	+	ENST00000265393	TAX1BP1	chr7	27824782	+	2081	397	148	2028	626
ENST00000393577	HMGA2	chr12	66232349	+	ENST00000409980	TAX1BP1	chr7	27824782	+	2279	397	148	2226	692
ENST00000393577	HMGA2	chr12	66232349	+	ENST00000433216	TAX1BP1	chr7	27824782	+	2064	397	148	2028	626
ENST00000393577	HMGA2	chr12	66232349	+	ENST00000396319	TAX1BP1	chr7	27824782	+	2587	397	148	2154	668
ENST00000393578	HMGA2	chr12	66232349	+	ENST00000543117	TAX1BP1	chr7	27824782	+	2956	1060	811	2691	626
ENST00000393578	HMGA2	chr12	66232349	+	ENST00000265393	TAX1BP1	chr7	27824782	+	2744	1060	811	2691	626
ENST00000393578	HMGA2	chr12	66232349	+	ENST00000409980	TAX1BP1	chr7	27824782	+	2942	1060	811	2889	692
ENST00000393578	HMGA2	chr12	66232349	+	ENST00000433216	TAX1BP1	chr7	27824782	+	2727	1060	811	2691	626
ENST00000393578	HMGA2	chr12	66232349	+	ENST00000396319	TAX1BP1	chr7	27824782	+	3250	1060	811	2817	668
ENST00000425208	HMGA2	chr12	66232349	+	ENST00000543117	TAX1BP1	chr7	27824782	+	2956	1060	811	2691	626
ENST00000425208	HMGA2	chr12	66232349	+	ENST00000265393	TAX1BP1	chr7	27824782	+	2744	1060	811	2691	626
ENST00000425208	HMGA2	chr12	66232349	+	ENST00000409980	TAX1BP1	chr7	27824782	+	2942	1060	811	2889	692
ENST00000425208	HMGA2	chr12	66232349	+	ENST00000433216	TAX1BP1	chr7	27824782	+	2727	1060	811	2691	626
ENST00000425208	HMGA2	chr12	66232349	+	ENST00000396319	TAX1BP1	chr7	27824782	+	3250	1060	811	2817	668
ENST00000536545	HMGA2	chr12	66232349	+	ENST00000543117	TAX1BP1	chr7	27824782	+	2956	1060	811	2691	626
ENST00000536545	HMGA2	chr12	66232349	+	ENST00000265393	TAX1BP1	chr7	27824782	+	2744	1060	811	2691	626
ENST00000536545	HMGA2	chr12	66232349	+	ENST00000409980	TAX1BP1	chr7	27824782	+	2942	1060	811	2889	692
ENST00000536545	HMGA2	chr12	66232349	+	ENST00000433216	TAX1BP1	chr7	27824782	+	2727	1060	811	2691	626
ENST00000536545	HMGA2	chr12	66232349	+	ENST00000396319	TAX1BP1	chr7	27824782	+	3250	1060	811	2817	668
ENST00000354636	HMGA2	chr12	66232349	+	ENST00000543117	TAX1BP1	chr7	27824782	+	2956	1060	811	2691	626
ENST00000354636	HMGA2	chr12	66232349	+	ENST00000265393	TAX1BP1	chr7	27824782	+	2744	1060	811	2691	626
ENST00000354636	HMGA2	chr12	66232349	+	ENST00000409980	TAX1BP1	chr7	27824782	+	2942	1060	811	2889	692
ENST00000354636	HMGA2	chr12	66232349	+	ENST00000433216	TAX1BP1	chr7	27824782	+	2727	1060	811	2691	626
ENST00000354636	HMGA2	chr12	66232349	+	ENST00000396319	TAX1BP1	chr7	27824782	+	3250	1060	811	2817	668

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000403681	ENST00000543117	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.001282316	0.99871767
ENST00000403681	ENST00000265393	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.001841708	0.9981583
ENST00000403681	ENST00000409980	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.001614956	0.9983851
ENST00000403681	ENST00000433216	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.00212873	0.9978713
ENST00000403681	ENST00000396319	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.000956669	0.9990433
ENST00000541363	ENST00000543117	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.001130233	0.9988697
ENST00000541363	ENST00000265393	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.002048965	0.9979511
ENST00000541363	ENST00000409980	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.001755453	0.9982445
ENST00000541363	ENST00000433216	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.002145285	0.99785465
ENST00000541363	ENST00000396319	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.000814285	0.99918574
ENST00000393577	ENST00000543117	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.001112477	0.9988875
ENST00000393577	ENST00000265393	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.001978202	0.99802184
ENST00000393577	ENST00000409980	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.001807186	0.99819285
ENST00000393577	ENST00000433216	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.002140537	0.9978594
ENST00000393577	ENST00000396319	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.000796278	0.99920374
ENST00000393578	ENST00000543117	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.000992824	0.99900717
ENST00000393578	ENST00000265393	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.001545304	0.9984547
ENST00000393578	ENST00000409980	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.001358148	0.9986419
ENST00000393578	ENST00000433216	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.001782746	0.9982173
ENST00000393578	ENST00000396319	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.000733724	0.9992663
ENST00000425208	ENST00000543117	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.000992824	0.99900717
ENST00000425208	ENST00000265393	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.001545304	0.9984547
ENST00000425208	ENST00000409980	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.001358148	0.9986419
ENST00000425208	ENST00000433216	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.001782746	0.9982173
ENST00000425208	ENST00000396319	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.000733724	0.9992663
ENST00000536545	ENST00000543117	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.000992824	0.99900717
ENST00000536545	ENST00000265393	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.001545304	0.9984547
ENST00000536545	ENST00000409980	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.001358148	0.9986419
ENST00000536545	ENST00000433216	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.001782746	0.9982173
ENST00000536545	ENST00000396319	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.000733724	0.9992663
ENST00000354636	ENST00000543117	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.000992824	0.99900717
ENST00000354636	ENST00000265393	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.001545304	0.9984547
ENST00000354636	ENST00000409980	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.001358148	0.9986419
ENST00000354636	ENST00000433216	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.001782746	0.9982173
ENST00000354636	ENST00000396319	HMGA2	chr12	66232349	+	TAX1BP1	chr7	27824782	+	0.000733724	0.9992663

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>36858_36858_1_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000354636_TAX1BP1_chr7_27824782_ENST00000265393_length(amino acids)=626AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTA

--------------------------------------------------------------

>36858_36858_2_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000354636_TAX1BP1_chr7_27824782_ENST00000396319_length(amino acids)=668AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKELKRSLENPAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGNPYASQETRDGADGAFYPDEIQRPP
VRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVE

--------------------------------------------------------------

>36858_36858_3_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000354636_TAX1BP1_chr7_27824782_ENST00000409980_length(amino acids)=692AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKLQLAEKDKEISGLISHLENLSREKELKRSLENPAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGN
PYASQETRDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVH

--------------------------------------------------------------

>36858_36858_4_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000354636_TAX1BP1_chr7_27824782_ENST00000433216_length(amino acids)=626AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTA

--------------------------------------------------------------

>36858_36858_5_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000354636_TAX1BP1_chr7_27824782_ENST00000543117_length(amino acids)=626AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTA

--------------------------------------------------------------

>36858_36858_6_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000393577_TAX1BP1_chr7_27824782_ENST00000265393_length(amino acids)=626AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTA

--------------------------------------------------------------

>36858_36858_7_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000393577_TAX1BP1_chr7_27824782_ENST00000396319_length(amino acids)=668AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKELKRSLENPAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGNPYASQETRDGADGAFYPDEIQRPP
VRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVE

--------------------------------------------------------------

>36858_36858_8_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000393577_TAX1BP1_chr7_27824782_ENST00000409980_length(amino acids)=692AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKLQLAEKDKEISGLISHLENLSREKELKRSLENPAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGN
PYASQETRDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVH

--------------------------------------------------------------

>36858_36858_9_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000393577_TAX1BP1_chr7_27824782_ENST00000433216_length(amino acids)=626AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTA

--------------------------------------------------------------

>36858_36858_10_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000393577_TAX1BP1_chr7_27824782_ENST00000543117_length(amino acids)=626AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTA

--------------------------------------------------------------

>36858_36858_11_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000393578_TAX1BP1_chr7_27824782_ENST00000265393_length(amino acids)=626AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTA

--------------------------------------------------------------

>36858_36858_12_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000393578_TAX1BP1_chr7_27824782_ENST00000396319_length(amino acids)=668AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKELKRSLENPAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGNPYASQETRDGADGAFYPDEIQRPP
VRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVE

--------------------------------------------------------------

>36858_36858_13_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000393578_TAX1BP1_chr7_27824782_ENST00000409980_length(amino acids)=692AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKLQLAEKDKEISGLISHLENLSREKELKRSLENPAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGN
PYASQETRDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVH

--------------------------------------------------------------

>36858_36858_14_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000393578_TAX1BP1_chr7_27824782_ENST00000433216_length(amino acids)=626AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTA

--------------------------------------------------------------

>36858_36858_15_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000393578_TAX1BP1_chr7_27824782_ENST00000543117_length(amino acids)=626AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTA

--------------------------------------------------------------

>36858_36858_16_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000403681_TAX1BP1_chr7_27824782_ENST00000265393_length(amino acids)=626AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTA

--------------------------------------------------------------

>36858_36858_17_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000403681_TAX1BP1_chr7_27824782_ENST00000396319_length(amino acids)=668AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKELKRSLENPAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGNPYASQETRDGADGAFYPDEIQRPP
VRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVE

--------------------------------------------------------------

>36858_36858_18_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000403681_TAX1BP1_chr7_27824782_ENST00000409980_length(amino acids)=692AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKLQLAEKDKEISGLISHLENLSREKELKRSLENPAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGN
PYASQETRDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVH

--------------------------------------------------------------

>36858_36858_19_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000403681_TAX1BP1_chr7_27824782_ENST00000433216_length(amino acids)=626AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTA

--------------------------------------------------------------

>36858_36858_20_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000403681_TAX1BP1_chr7_27824782_ENST00000543117_length(amino acids)=626AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTA

--------------------------------------------------------------

>36858_36858_21_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000425208_TAX1BP1_chr7_27824782_ENST00000265393_length(amino acids)=626AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTA

--------------------------------------------------------------

>36858_36858_22_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000425208_TAX1BP1_chr7_27824782_ENST00000396319_length(amino acids)=668AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKELKRSLENPAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGNPYASQETRDGADGAFYPDEIQRPP
VRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVE

--------------------------------------------------------------

>36858_36858_23_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000425208_TAX1BP1_chr7_27824782_ENST00000409980_length(amino acids)=692AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKLQLAEKDKEISGLISHLENLSREKELKRSLENPAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGN
PYASQETRDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVH

--------------------------------------------------------------

>36858_36858_24_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000425208_TAX1BP1_chr7_27824782_ENST00000433216_length(amino acids)=626AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTA

--------------------------------------------------------------

>36858_36858_25_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000425208_TAX1BP1_chr7_27824782_ENST00000543117_length(amino acids)=626AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTA

--------------------------------------------------------------

>36858_36858_26_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000536545_TAX1BP1_chr7_27824782_ENST00000265393_length(amino acids)=626AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTA

--------------------------------------------------------------

>36858_36858_27_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000536545_TAX1BP1_chr7_27824782_ENST00000396319_length(amino acids)=668AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKELKRSLENPAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGNPYASQETRDGADGAFYPDEIQRPP
VRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVE

--------------------------------------------------------------

>36858_36858_28_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000536545_TAX1BP1_chr7_27824782_ENST00000409980_length(amino acids)=692AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKLQLAEKDKEISGLISHLENLSREKELKRSLENPAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGN
PYASQETRDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVH

--------------------------------------------------------------

>36858_36858_29_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000536545_TAX1BP1_chr7_27824782_ENST00000433216_length(amino acids)=626AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTA

--------------------------------------------------------------

>36858_36858_30_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000536545_TAX1BP1_chr7_27824782_ENST00000543117_length(amino acids)=626AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTA

--------------------------------------------------------------

>36858_36858_31_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000541363_TAX1BP1_chr7_27824782_ENST00000265393_length(amino acids)=626AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTA

--------------------------------------------------------------

>36858_36858_32_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000541363_TAX1BP1_chr7_27824782_ENST00000396319_length(amino acids)=668AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKELKRSLENPAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGNPYASQETRDGADGAFYPDEIQRPP
VRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVE

--------------------------------------------------------------

>36858_36858_33_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000541363_TAX1BP1_chr7_27824782_ENST00000409980_length(amino acids)=692AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKLQLAEKDKEISGLISHLENLSREKELKRSLENPAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGN
PYASQETRDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVH

--------------------------------------------------------------

>36858_36858_34_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000541363_TAX1BP1_chr7_27824782_ENST00000433216_length(amino acids)=626AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTA

--------------------------------------------------------------

>36858_36858_35_HMGA2-TAX1BP1_HMGA2_chr12_66232349_ENST00000541363_TAX1BP1_chr7_27824782_ENST00000543117_length(amino acids)=626AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWGLTEVTQ
SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV
QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL
HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKT
GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVK
IAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTA

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:66232349/chr7:27824782)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HMGA2 P52926	.
FUNCTION: Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner (PubMed:28796236). {ECO:0000250\|UniProtKB:P52927, ECO:0000269\|PubMed:14645522, ECO:0000269\|PubMed:28796236}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HMGA2

chr12:66232349

chr7:27824782

ENST00000354636

24_34

83.0

107.0

DNA binding

Note=A.T hook 1

Hgene

HMGA2

chr12:66232349

chr7:27824782

ENST00000354636

44_54

83.0

107.0

DNA binding

Note=A.T hook 2

Hgene

HMGA2

chr12:66232349

chr7:27824782

ENST00000354636

71_82

83.0

107.0

DNA binding

Note=A.T hook 3

Hgene

HMGA2

chr12:66232349

chr7:27824782

ENST00000393578

24_34

83.0

91.0

DNA binding

Note=A.T hook 1

Hgene

HMGA2

chr12:66232349

chr7:27824782

ENST00000393578

44_54

83.0

91.0

DNA binding

Note=A.T hook 2

Hgene

HMGA2

chr12:66232349

chr7:27824782

ENST00000393578

71_82

83.0

91.0

DNA binding

Note=A.T hook 3

Hgene

HMGA2

chr12:66232349

chr7:27824782

ENST00000403681

24_34

83.0

110.0

DNA binding

Note=A.T hook 1

Hgene

HMGA2

chr12:66232349

chr7:27824782

ENST00000403681

44_54

83.0

110.0

DNA binding

Note=A.T hook 2

Hgene

HMGA2

chr12:66232349

chr7:27824782

ENST00000403681

71_82

83.0

110.0

DNA binding

Note=A.T hook 3

Hgene

HMGA2

chr12:66232349

chr7:27824782

ENST00000425208

24_34

83.0

93.0

DNA binding

Note=A.T hook 1

Hgene

HMGA2

chr12:66232349

chr7:27824782

ENST00000425208

44_54

83.0

93.0

DNA binding

Note=A.T hook 2

Hgene

HMGA2

chr12:66232349

chr7:27824782

ENST00000425208

71_82

83.0

93.0

DNA binding

Note=A.T hook 3

Tgene

TAX1BP1

chr12:66232349

chr7:27824782

ENST00000433216

144_599

47.0

591.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TAX1BP1

chr12:66232349

chr7:27824782

ENST00000265393

320_420

204.0

748.0

Region

Note=Oligomerization

Tgene

TAX1BP1

chr12:66232349

chr7:27824782

ENST00000396319

320_420

204.0

790.0

Region

Note=Oligomerization

Tgene

TAX1BP1

chr12:66232349

chr7:27824782

ENST00000433216

320_420

47.0

591.0

Region

Note=Oligomerization

Tgene

TAX1BP1

chr12:66232349

chr7:27824782

ENST00000543117

320_420

204.0

748.0

Region

Note=Oligomerization

Tgene

TAX1BP1

chr12:66232349

chr7:27824782

ENST00000265393

727_753

204.0

748.0

Zinc finger

UBZ1-type 1

Tgene

TAX1BP1

chr12:66232349

chr7:27824782

ENST00000265393

754_780

204.0

748.0

Zinc finger

UBZ1-type 2

Tgene

TAX1BP1

chr12:66232349

chr7:27824782

ENST00000396319

727_753

204.0

790.0

Zinc finger

UBZ1-type 1

Tgene

TAX1BP1

chr12:66232349

chr7:27824782

ENST00000396319

754_780

204.0

790.0

Zinc finger

UBZ1-type 2

Tgene

TAX1BP1

chr12:66232349

chr7:27824782

ENST00000433216

727_753

47.0

591.0

Zinc finger

UBZ1-type 1

Tgene

TAX1BP1

chr12:66232349

chr7:27824782

ENST00000433216

754_780

47.0

591.0

Zinc finger

UBZ1-type 2

Tgene

TAX1BP1

chr12:66232349

chr7:27824782

ENST00000543117

727_753

204.0

748.0

Zinc finger

UBZ1-type 1

Tgene

TAX1BP1

chr12:66232349

chr7:27824782

ENST00000543117

754_780

204.0

748.0

Zinc finger

UBZ1-type 2

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TAX1BP1

chr12:66232349

chr7:27824782

ENST00000265393

144_599

204.0

748.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TAX1BP1

chr12:66232349

chr7:27824782

ENST00000396319

144_599

204.0

790.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TAX1BP1

chr12:66232349

chr7:27824782

ENST00000543117

144_599

204.0

748.0

Coiled coil

Ontology_term=ECO:0000255

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

HMGA2

RELA, NFKB1, PIAS3, RB1, PRMT6, NPM1, SMAD1, SMAD5, SMAD9, PRKCA, HDGF, PTBP1, APEX1, SYNCRIP, XRCC6, PSIP1, PA2G4, PCBP2, E4F1, OBSL1, HIST1H3A, CREB1, NFATC1, PCGF1, POU5F1, DLST, EZH2, SUZ12, MYC, TP53, MDM2, CSK, VRK1, HIST1H1B, PRKAG2, DUX4, DUX4L9, SYDE1, ARHGAP21, ARHGAP39, Plekhg5, ZNF263, MAFB, KAT2B, HIST1H2BG, LMNB1, NDUFAF7, CSNK2A1, LIG3, SUPT16H, VRK3, SP2, C1QBP, PARP2, TOP3A, CSNK2A2, XPC, RANBP17, PARP1, SUPV3L1, HIST2H2AC, HIST2H3PS2, KPNA4, USP7,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
HMGA2
TAX1BP1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to HMGA2-TAX1BP1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to HMGA2-TAX1BP1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	HMGA2	C1519176	Salivary Gland Pleomorphic Adenoma	2	ORPHANET
Hgene	HMGA2	C0005612	Birth Weight	1	CTD_human
Hgene	HMGA2	C0006826	Malignant Neoplasms	1	CTD_human
Hgene	HMGA2	C0027626	Neoplasm Invasiveness	1	CTD_human
Hgene	HMGA2	C0027651	Neoplasms	1	CTD_human
Hgene	HMGA2	C0086692	Benign Neoplasm	1	CTD_human
Hgene	HMGA2	C0175693	Russell-Silver syndrome	1	GENOMICS_ENGLAND
Hgene	HMGA2	C0473935	Radiolabeled somatostatin analog study	1	GENOMICS_ENGLAND
Hgene	HMGA2	C0796160	MENTAL RETARDATION, X-LINKED, SNYDER-ROBINSON TYPE	1	GENOMICS_ENGLAND
Hgene	HMGA2	C1096309	Myolipoma	1	GENOMICS_ENGLAND
Hgene	HMGA2	C4305140	12q14 microdeletion syndrome	1	ORPHANET