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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:HSP90AB1-CACYBP

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: HSP90AB1-CACYBP
	FusionPDB ID: 37791
	FusionGDB2.0 ID: 37791
		Hgene	Tgene
	Gene symbol	HSP90AB1	CACYBP
	Gene ID	3326	27101
	Gene name	heat shock protein 90 alpha family class B member 1	calcyclin binding protein
	Synonyms	D6S182\|HSP84\|HSP90B\|HSPC2\|HSPCB	GIG5\|PNAS-107\|S100A6BP\|SIP
	Cytomap	6p21.1	1q25.1
	Type of gene	protein-coding	protein-coding
	Description	heat shock protein HSP 90-betaHSP90-betaheat shock 84 kDaheat shock 90kD protein 1, betaheat shock protein 90 kDaheat shock protein 90kDa alpha (cytosolic), class B member 1heat shock protein 90kDa alpha family class B member 1	calcyclin-binding proteinS100A6-binding proteinSiah-interacting protein (SIP)growth-inhibiting gene 5 proteinhCacyBP
	Modification date	20200327	20200327
	UniProtAcc	P08238	Q9HB71
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000353801, ENST00000371554, ENST00000371646,	ENST00000367679, ENST00000367681, ENST00000405362, ENST00000406752,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	20 X 20 X 7=2800	4 X 5 X 3=60
	# samples	22	6
	** MAII score	log2(22/2800*10)=-3.66985139830767 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/60*10)=0
Context (manual curation of fusion genes in FusionPDB)	PubMed: HSP90AB1 [Title/Abstract] AND CACYBP [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	HSP90AB1(44219937)-CACYBP(174973873), # samples:1
Anticipated loss of major functional domain due to fusion event.	HSP90AB1-CACYBP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HSP90AB1-CACYBP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HSP90AB1-CACYBP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. HSP90AB1-CACYBP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HSP90AB1	GO:0007004	telomere maintenance via telomerase	10197982
Hgene	HSP90AB1	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	24613385
Hgene	HSP90AB1	GO:0031396	regulation of protein ubiquitination	16809764
Hgene	HSP90AB1	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	24613385
Hgene	HSP90AB1	GO:0032516	positive regulation of phosphoprotein phosphatase activity	26593036
Hgene	HSP90AB1	GO:0051131	chaperone-mediated protein complex assembly	10811660
Hgene	HSP90AB1	GO:0051973	positive regulation of telomerase activity	10197982
Hgene	HSP90AB1	GO:1901389	negative regulation of transforming growth factor beta activation	20599762
Hgene	HSP90AB1	GO:1905323	telomerase holoenzyme complex assembly	10197982
Hgene	HSP90AB1	GO:2000010	positive regulation of protein localization to cell surface	23431407

Fusion gene breakpoints across HSP90AB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CACYBP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BM147273	HSP90AB1	chr6	44219937	-	CACYBP	chr1	174973873	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000353801	HSP90AB1	chr6	44219937	-	ENST00000367681	CACYBP	chr1	174973873	-	3835	1651	122	1621	499
ENST00000353801	HSP90AB1	chr6	44219937	-	ENST00000367679	CACYBP	chr1	174973873	-	3830	1651	122	1621	499
ENST00000353801	HSP90AB1	chr6	44219937	-	ENST00000406752	CACYBP	chr1	174973873	-	1755	1651	122	1621	499
ENST00000353801	HSP90AB1	chr6	44219937	-	ENST00000405362	CACYBP	chr1	174973873	-	2199	1651	122	1621	499
ENST00000371646	HSP90AB1	chr6	44219937	-	ENST00000367681	CACYBP	chr1	174973873	-	3822	1638	73	1608	511
ENST00000371646	HSP90AB1	chr6	44219937	-	ENST00000367679	CACYBP	chr1	174973873	-	3817	1638	73	1608	511
ENST00000371646	HSP90AB1	chr6	44219937	-	ENST00000406752	CACYBP	chr1	174973873	-	1742	1638	73	1608	511
ENST00000371646	HSP90AB1	chr6	44219937	-	ENST00000405362	CACYBP	chr1	174973873	-	2186	1638	73	1608	511
ENST00000371554	HSP90AB1	chr6	44219937	-	ENST00000367681	CACYBP	chr1	174973873	-	3927	1743	214	1713	499
ENST00000371554	HSP90AB1	chr6	44219937	-	ENST00000367679	CACYBP	chr1	174973873	-	3922	1743	214	1713	499
ENST00000371554	HSP90AB1	chr6	44219937	-	ENST00000406752	CACYBP	chr1	174973873	-	1847	1743	214	1713	499
ENST00000371554	HSP90AB1	chr6	44219937	-	ENST00000405362	CACYBP	chr1	174973873	-	2291	1743	214	1713	499

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000353801	ENST00000367681	HSP90AB1	chr6	44219937	-	CACYBP	chr1	174973873	-	0.000353128	0.9996469
ENST00000353801	ENST00000367679	HSP90AB1	chr6	44219937	-	CACYBP	chr1	174973873	-	0.000356234	0.9996438
ENST00000353801	ENST00000406752	HSP90AB1	chr6	44219937	-	CACYBP	chr1	174973873	-	0.002009161	0.99799085
ENST00000353801	ENST00000405362	HSP90AB1	chr6	44219937	-	CACYBP	chr1	174973873	-	0.001044751	0.99895525
ENST00000371646	ENST00000367681	HSP90AB1	chr6	44219937	-	CACYBP	chr1	174973873	-	0.000364692	0.99963534
ENST00000371646	ENST00000367679	HSP90AB1	chr6	44219937	-	CACYBP	chr1	174973873	-	0.000367876	0.9996321
ENST00000371646	ENST00000406752	HSP90AB1	chr6	44219937	-	CACYBP	chr1	174973873	-	0.00211951	0.99788046
ENST00000371646	ENST00000405362	HSP90AB1	chr6	44219937	-	CACYBP	chr1	174973873	-	0.001122267	0.9988777
ENST00000371554	ENST00000367681	HSP90AB1	chr6	44219937	-	CACYBP	chr1	174973873	-	0.000318895	0.9996811
ENST00000371554	ENST00000367679	HSP90AB1	chr6	44219937	-	CACYBP	chr1	174973873	-	0.000321418	0.9996786
ENST00000371554	ENST00000406752	HSP90AB1	chr6	44219937	-	CACYBP	chr1	174973873	-	0.001282454	0.99871755
ENST00000371554	ENST00000405362	HSP90AB1	chr6	44219937	-	CACYBP	chr1	174973873	-	0.000787525	0.9992125

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>37791_37791_1_HSP90AB1-CACYBP_HSP90AB1_chr6_44219937_ENST00000353801_CACYBP_chr1_174973873_ENST00000367679_length(amino acids)=499AA_BP=
MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTG
IGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKKKTK
KIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRR

--------------------------------------------------------------

>37791_37791_2_HSP90AB1-CACYBP_HSP90AB1_chr6_44219937_ENST00000353801_CACYBP_chr1_174973873_ENST00000367681_length(amino acids)=499AA_BP=
MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTG
IGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKKKTK
KIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRR

--------------------------------------------------------------

>37791_37791_3_HSP90AB1-CACYBP_HSP90AB1_chr6_44219937_ENST00000353801_CACYBP_chr1_174973873_ENST00000405362_length(amino acids)=499AA_BP=
MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTG
IGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKKKTK
KIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRR

--------------------------------------------------------------

>37791_37791_4_HSP90AB1-CACYBP_HSP90AB1_chr6_44219937_ENST00000353801_CACYBP_chr1_174973873_ENST00000406752_length(amino acids)=499AA_BP=
MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTG
IGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKKKTK
KIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRR

--------------------------------------------------------------

>37791_37791_5_HSP90AB1-CACYBP_HSP90AB1_chr6_44219937_ENST00000371554_CACYBP_chr1_174973873_ENST00000367679_length(amino acids)=499AA_BP=
MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTG
IGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKKKTK
KIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRR

--------------------------------------------------------------

>37791_37791_6_HSP90AB1-CACYBP_HSP90AB1_chr6_44219937_ENST00000371554_CACYBP_chr1_174973873_ENST00000367681_length(amino acids)=499AA_BP=
MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTG
IGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKKKTK
KIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRR

--------------------------------------------------------------

>37791_37791_7_HSP90AB1-CACYBP_HSP90AB1_chr6_44219937_ENST00000371554_CACYBP_chr1_174973873_ENST00000405362_length(amino acids)=499AA_BP=
MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTG
IGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKKKTK
KIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRR

--------------------------------------------------------------

>37791_37791_8_HSP90AB1-CACYBP_HSP90AB1_chr6_44219937_ENST00000371554_CACYBP_chr1_174973873_ENST00000406752_length(amino acids)=499AA_BP=
MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTG
IGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKKKTK
KIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRR

--------------------------------------------------------------

>37791_37791_9_HSP90AB1-CACYBP_HSP90AB1_chr6_44219937_ENST00000371646_CACYBP_chr1_174973873_ENST00000367679_length(amino acids)=511AA_BP=
MLTITYNPFLFKMPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPN
PQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVR
ADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEE
DDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKK
KKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLK

--------------------------------------------------------------

>37791_37791_10_HSP90AB1-CACYBP_HSP90AB1_chr6_44219937_ENST00000371646_CACYBP_chr1_174973873_ENST00000367681_length(amino acids)=511AA_BP=
MLTITYNPFLFKMPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPN
PQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVR
ADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEE
DDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKK
KKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLK

--------------------------------------------------------------

>37791_37791_11_HSP90AB1-CACYBP_HSP90AB1_chr6_44219937_ENST00000371646_CACYBP_chr1_174973873_ENST00000405362_length(amino acids)=511AA_BP=
MLTITYNPFLFKMPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPN
PQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVR
ADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEE
DDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKK
KKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLK

--------------------------------------------------------------

>37791_37791_12_HSP90AB1-CACYBP_HSP90AB1_chr6_44219937_ENST00000371646_CACYBP_chr1_174973873_ENST00000406752_length(amino acids)=511AA_BP=
MLTITYNPFLFKMPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPN
PQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVR
ADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEE
DDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKK
KKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLK

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:44219937/chr1:174973873)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HSP90AB1 P08238	CACYBP Q9HB71
FUNCTION: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269\|PubMed:16478993, ECO:0000269\|PubMed:18239673, ECO:0000269\|PubMed:19696785, ECO:0000269\|PubMed:20353823, ECO:0000269\|PubMed:24613385, ECO:0000269\|PubMed:32272059, ECO:0000303\|PubMed:25973397, ECO:0000303\|PubMed:26991466, ECO:0000303\|PubMed:27295069}.	FUNCTION: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1). {ECO:0000269\|PubMed:16085652}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CACYBP

chr6:44219937

chr1:174973873

ENST00000367679

168_228

229.0

Domain

SGS

Tgene

CACYBP

chr6:44219937

chr1:174973873

ENST00000367679

73_167

229.0

Domain

Tgene

CACYBP

chr6:44219937

chr1:174973873

ENST00000367681

168_228

186.0

Domain

SGS

Tgene

CACYBP

chr6:44219937

chr1:174973873

ENST00000367681

73_167

186.0

Domain

Tgene

CACYBP

chr6:44219937

chr1:174973873

ENST00000405362

168_228

186.0

Domain

SGS

Tgene

CACYBP

chr6:44219937

chr1:174973873

ENST00000405362

73_167

186.0

Domain

Tgene

CACYBP

chr6:44219937

chr1:174973873

ENST00000406752

168_228

0.0

81.0

Domain

SGS

Tgene

CACYBP

chr6:44219937

chr1:174973873

ENST00000406752

73_167

0.0

81.0

Domain

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HSP90AB1

chr6:44219937

chr1:174973873

ENST00000353801

720_724

725.0

Motif

Note=TPR repeat-binding

Hgene

HSP90AB1

chr6:44219937

chr1:174973873

ENST00000371554

720_724

725.0

Motif

Note=TPR repeat-binding

Hgene

HSP90AB1

chr6:44219937

chr1:174973873

ENST00000371646

720_724

725.0

Motif

Note=TPR repeat-binding

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
HSP90AB1
CACYBP

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	HSP90AB1	chr6:44219937	chr1:174973873	ENST00000353801	-	1	12	215_552	0	725.0	AHSA1
Hgene	HSP90AB1	chr6:44219937	chr1:174973873	ENST00000371554	-	1	12	215_552	0	725.0	AHSA1
Hgene	HSP90AB1	chr6:44219937	chr1:174973873	ENST00000371646	-	1	12	215_552	0	725.0	AHSA1
Hgene	HSP90AB1	chr6:44219937	chr1:174973873	ENST00000353801	-	1	12	2_214	0	725.0	BIRC2
Hgene	HSP90AB1	chr6:44219937	chr1:174973873	ENST00000371554	-	1	12	2_214	0	725.0	BIRC2
Hgene	HSP90AB1	chr6:44219937	chr1:174973873	ENST00000371646	-	1	12	2_214	0	725.0	BIRC2
Hgene	HSP90AB1	chr6:44219937	chr1:174973873	ENST00000353801	-	1	12	620_723	0	725.0	NR1D1
Hgene	HSP90AB1	chr6:44219937	chr1:174973873	ENST00000371554	-	1	12	620_723	0	725.0	NR1D1
Hgene	HSP90AB1	chr6:44219937	chr1:174973873	ENST00000371646	-	1	12	620_723	0	725.0	NR1D1
Hgene	HSP90AB1	chr6:44219937	chr1:174973873	ENST00000353801	-	1	12	264_608	0	725.0	NR3C1
Hgene	HSP90AB1	chr6:44219937	chr1:174973873	ENST00000353801	-	1	12	9_231	0	725.0	NR3C1
Hgene	HSP90AB1	chr6:44219937	chr1:174973873	ENST00000371554	-	1	12	264_608	0	725.0	NR3C1
Hgene	HSP90AB1	chr6:44219937	chr1:174973873	ENST00000371554	-	1	12	9_231	0	725.0	NR3C1
Hgene	HSP90AB1	chr6:44219937	chr1:174973873	ENST00000371646	-	1	12	264_608	0	725.0	NR3C1
Hgene	HSP90AB1	chr6:44219937	chr1:174973873	ENST00000371646	-	1	12	9_231	0	725.0	NR3C1
Hgene	HSP90AB1	chr6:44219937	chr1:174973873	ENST00000353801	-	1	12	2_527	0	725.0	TP53
Hgene	HSP90AB1	chr6:44219937	chr1:174973873	ENST00000371554	-	1	12	2_527	0	725.0	TP53
Hgene	HSP90AB1	chr6:44219937	chr1:174973873	ENST00000371646	-	1	12	2_527	0	725.0	TP53

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Related Drugs to HSP90AB1-CACYBP

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to HSP90AB1-CACYBP

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source