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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:IFT74-CACNA2D3

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: IFT74-CACNA2D3
	FusionPDB ID: 38441
	FusionGDB2.0 ID: 38441
		Hgene	Tgene
	Gene symbol	IFT74	CACNA2D3
	Gene ID	80173	55799
	Gene name	intraflagellar transport 74	calcium voltage-gated channel auxiliary subunit alpha2delta 3
	Synonyms	CCDC2\|CMG-1\|CMG1	HSA272268
	Cytomap	9p21.2	3p21.1-p14.3
	Type of gene	protein-coding	protein-coding
	Description	intraflagellar transport protein 74 homologcapillary morphogenesis gene 1 proteincapillary morphogenesis protein 1coiled-coil domain containing 2coiled-coil domain-containing protein 2intraflagellar transport 74 homolog	voltage-dependent calcium channel subunit alpha-2/delta-3calcium channel alpha2-delta3 subunitcalcium channel, voltage-dependent, alpha 2/delta 3 subunitcalcium channel, voltage-dependent, alpha 2/delta subunit 3voltage-gated calcium channel subunit a
	Modification date	20200326	20200313
	UniProtAcc	Q96LB3	Q8IZS8
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000380062, ENST00000429045, ENST00000433700, ENST00000443698,	ENST00000478261, ENST00000288197, ENST00000415676, ENST00000474759, ENST00000490478,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	5 X 2 X 5=50	16 X 13 X 9=1872
	# samples	5	16
	** MAII score	log2(5/50*10)=0	log2(16/1872*10)=-3.54843662469604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: IFT74 [Title/Abstract] AND CACNA2D3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	IFT74(26990193)-CACNA2D3(55038790), # samples:3 CACNA2D3(55021780)-IFT74(27009018), # samples:2
Anticipated loss of major functional domain due to fusion event.	CACNA2D3-IFT74 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CACNA2D3-IFT74 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. IFT74-CACNA2D3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. IFT74-CACNA2D3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. IFT74-CACNA2D3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. IFT74-CACNA2D3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across IFT74 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CACNA2D3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	THCA	TCGA-E8-A432-01A	IFT74	chr9	26990193	-	CACNA2D3	chr3	55038790	+
ChimerDB4	THCA	TCGA-E8-A432-01A	IFT74	chr9	26990193	+	CACNA2D3	chr3	55038790	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000433700	IFT74	chr9	26990193	+	ENST00000415676	CACNA2D3	chr3	55038790	+	1567	714	127	1299	390
ENST00000433700	IFT74	chr9	26990193	+	ENST00000288197	CACNA2D3	chr3	55038790	+	1647	714	127	1299	390
ENST00000433700	IFT74	chr9	26990193	+	ENST00000474759	CACNA2D3	chr3	55038790	+	1651	714	127	1299	390
ENST00000433700	IFT74	chr9	26990193	+	ENST00000490478	CACNA2D3	chr3	55038790	+	1651	714	127	1299	390
ENST00000443698	IFT74	chr9	26990193	+	ENST00000415676	CACNA2D3	chr3	55038790	+	1611	758	171	1343	390
ENST00000443698	IFT74	chr9	26990193	+	ENST00000288197	CACNA2D3	chr3	55038790	+	1691	758	171	1343	390
ENST00000443698	IFT74	chr9	26990193	+	ENST00000474759	CACNA2D3	chr3	55038790	+	1695	758	171	1343	390
ENST00000443698	IFT74	chr9	26990193	+	ENST00000490478	CACNA2D3	chr3	55038790	+	1695	758	171	1343	390
ENST00000380062	IFT74	chr9	26990193	+	ENST00000415676	CACNA2D3	chr3	55038790	+	1603	750	163	1335	390
ENST00000380062	IFT74	chr9	26990193	+	ENST00000288197	CACNA2D3	chr3	55038790	+	1683	750	163	1335	390
ENST00000380062	IFT74	chr9	26990193	+	ENST00000474759	CACNA2D3	chr3	55038790	+	1687	750	163	1335	390
ENST00000380062	IFT74	chr9	26990193	+	ENST00000490478	CACNA2D3	chr3	55038790	+	1687	750	163	1335	390
ENST00000429045	IFT74	chr9	26990193	+	ENST00000415676	CACNA2D3	chr3	55038790	+	1497	644	57	1229	390
ENST00000429045	IFT74	chr9	26990193	+	ENST00000288197	CACNA2D3	chr3	55038790	+	1577	644	57	1229	390
ENST00000429045	IFT74	chr9	26990193	+	ENST00000474759	CACNA2D3	chr3	55038790	+	1581	644	57	1229	390
ENST00000429045	IFT74	chr9	26990193	+	ENST00000490478	CACNA2D3	chr3	55038790	+	1581	644	57	1229	390

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000433700	ENST00000415676	IFT74	chr9	26990193	+	CACNA2D3	chr3	55038790	+	0.000880775	0.9991192
ENST00000433700	ENST00000288197	IFT74	chr9	26990193	+	CACNA2D3	chr3	55038790	+	0.000620338	0.99937963
ENST00000433700	ENST00000474759	IFT74	chr9	26990193	+	CACNA2D3	chr3	55038790	+	0.00060862	0.9993913
ENST00000433700	ENST00000490478	IFT74	chr9	26990193	+	CACNA2D3	chr3	55038790	+	0.00060862	0.9993913
ENST00000443698	ENST00000415676	IFT74	chr9	26990193	+	CACNA2D3	chr3	55038790	+	0.001023598	0.99897647
ENST00000443698	ENST00000288197	IFT74	chr9	26990193	+	CACNA2D3	chr3	55038790	+	0.000702522	0.9992975
ENST00000443698	ENST00000474759	IFT74	chr9	26990193	+	CACNA2D3	chr3	55038790	+	0.000686641	0.99931335
ENST00000443698	ENST00000490478	IFT74	chr9	26990193	+	CACNA2D3	chr3	55038790	+	0.000686641	0.99931335
ENST00000380062	ENST00000415676	IFT74	chr9	26990193	+	CACNA2D3	chr3	55038790	+	0.000935281	0.99906474
ENST00000380062	ENST00000288197	IFT74	chr9	26990193	+	CACNA2D3	chr3	55038790	+	0.000668026	0.9993319
ENST00000380062	ENST00000474759	IFT74	chr9	26990193	+	CACNA2D3	chr3	55038790	+	0.000657086	0.99934286
ENST00000380062	ENST00000490478	IFT74	chr9	26990193	+	CACNA2D3	chr3	55038790	+	0.000657086	0.99934286
ENST00000429045	ENST00000415676	IFT74	chr9	26990193	+	CACNA2D3	chr3	55038790	+	0.000878886	0.9991211
ENST00000429045	ENST00000288197	IFT74	chr9	26990193	+	CACNA2D3	chr3	55038790	+	0.000613746	0.9993862
ENST00000429045	ENST00000474759	IFT74	chr9	26990193	+	CACNA2D3	chr3	55038790	+	0.000601005	0.99939895
ENST00000429045	ENST00000490478	IFT74	chr9	26990193	+	CACNA2D3	chr3	55038790	+	0.000601005	0.99939895

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>38441_38441_1_IFT74-CACNA2D3_IFT74_chr9_26990193_ENST00000380062_CACNA2D3_chr3_55038790_ENST00000288197_length(amino acids)=390AA_BP=196
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGVLSSQIKVAHRPVTQQGLTGMKTGTKGPQRQ
ILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN
DRETQSLDVIFTERQAITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDT
EYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCHGFHPE

--------------------------------------------------------------

>38441_38441_2_IFT74-CACNA2D3_IFT74_chr9_26990193_ENST00000380062_CACNA2D3_chr3_55038790_ENST00000415676_length(amino acids)=390AA_BP=196
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGVLSSQIKVAHRPVTQQGLTGMKTGTKGPQRQ
ILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN
DRETQSLDVIFTERQAITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDT
EYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCHGFHPE

--------------------------------------------------------------

>38441_38441_3_IFT74-CACNA2D3_IFT74_chr9_26990193_ENST00000380062_CACNA2D3_chr3_55038790_ENST00000474759_length(amino acids)=390AA_BP=196
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGVLSSQIKVAHRPVTQQGLTGMKTGTKGPQRQ
ILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN
DRETQSLDVIFTERQAITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDT
EYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCHGFHPE

--------------------------------------------------------------

>38441_38441_4_IFT74-CACNA2D3_IFT74_chr9_26990193_ENST00000380062_CACNA2D3_chr3_55038790_ENST00000490478_length(amino acids)=390AA_BP=196
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGVLSSQIKVAHRPVTQQGLTGMKTGTKGPQRQ
ILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN
DRETQSLDVIFTERQAITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDT
EYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCHGFHPE

--------------------------------------------------------------

>38441_38441_5_IFT74-CACNA2D3_IFT74_chr9_26990193_ENST00000429045_CACNA2D3_chr3_55038790_ENST00000288197_length(amino acids)=390AA_BP=196
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGVLSSQIKVAHRPVTQQGLTGMKTGTKGPQRQ
ILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN
DRETQSLDVIFTERQAITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDT
EYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCHGFHPE

--------------------------------------------------------------

>38441_38441_6_IFT74-CACNA2D3_IFT74_chr9_26990193_ENST00000429045_CACNA2D3_chr3_55038790_ENST00000415676_length(amino acids)=390AA_BP=196
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGVLSSQIKVAHRPVTQQGLTGMKTGTKGPQRQ
ILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN
DRETQSLDVIFTERQAITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDT
EYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCHGFHPE

--------------------------------------------------------------

>38441_38441_7_IFT74-CACNA2D3_IFT74_chr9_26990193_ENST00000429045_CACNA2D3_chr3_55038790_ENST00000474759_length(amino acids)=390AA_BP=196
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGVLSSQIKVAHRPVTQQGLTGMKTGTKGPQRQ
ILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN
DRETQSLDVIFTERQAITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDT
EYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCHGFHPE

--------------------------------------------------------------

>38441_38441_8_IFT74-CACNA2D3_IFT74_chr9_26990193_ENST00000429045_CACNA2D3_chr3_55038790_ENST00000490478_length(amino acids)=390AA_BP=196
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGVLSSQIKVAHRPVTQQGLTGMKTGTKGPQRQ
ILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN
DRETQSLDVIFTERQAITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDT
EYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCHGFHPE

--------------------------------------------------------------

>38441_38441_9_IFT74-CACNA2D3_IFT74_chr9_26990193_ENST00000433700_CACNA2D3_chr3_55038790_ENST00000288197_length(amino acids)=390AA_BP=196
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGVLSSQIKVAHRPVTQQGLTGMKTGTKGPQRQ
ILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN
DRETQSLDVIFTERQAITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDT
EYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCHGFHPE

--------------------------------------------------------------

>38441_38441_10_IFT74-CACNA2D3_IFT74_chr9_26990193_ENST00000433700_CACNA2D3_chr3_55038790_ENST00000415676_length(amino acids)=390AA_BP=196
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGVLSSQIKVAHRPVTQQGLTGMKTGTKGPQRQ
ILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN
DRETQSLDVIFTERQAITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDT
EYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCHGFHPE

--------------------------------------------------------------

>38441_38441_11_IFT74-CACNA2D3_IFT74_chr9_26990193_ENST00000433700_CACNA2D3_chr3_55038790_ENST00000474759_length(amino acids)=390AA_BP=196
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGVLSSQIKVAHRPVTQQGLTGMKTGTKGPQRQ
ILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN
DRETQSLDVIFTERQAITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDT
EYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCHGFHPE

--------------------------------------------------------------

>38441_38441_12_IFT74-CACNA2D3_IFT74_chr9_26990193_ENST00000433700_CACNA2D3_chr3_55038790_ENST00000490478_length(amino acids)=390AA_BP=196
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGVLSSQIKVAHRPVTQQGLTGMKTGTKGPQRQ
ILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN
DRETQSLDVIFTERQAITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDT
EYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCHGFHPE

--------------------------------------------------------------

>38441_38441_13_IFT74-CACNA2D3_IFT74_chr9_26990193_ENST00000443698_CACNA2D3_chr3_55038790_ENST00000288197_length(amino acids)=390AA_BP=196
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGVLSSQIKVAHRPVTQQGLTGMKTGTKGPQRQ
ILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN
DRETQSLDVIFTERQAITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDT
EYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCHGFHPE

--------------------------------------------------------------

>38441_38441_14_IFT74-CACNA2D3_IFT74_chr9_26990193_ENST00000443698_CACNA2D3_chr3_55038790_ENST00000415676_length(amino acids)=390AA_BP=196
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGVLSSQIKVAHRPVTQQGLTGMKTGTKGPQRQ
ILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN
DRETQSLDVIFTERQAITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDT
EYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCHGFHPE

--------------------------------------------------------------

>38441_38441_15_IFT74-CACNA2D3_IFT74_chr9_26990193_ENST00000443698_CACNA2D3_chr3_55038790_ENST00000474759_length(amino acids)=390AA_BP=196
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGVLSSQIKVAHRPVTQQGLTGMKTGTKGPQRQ
ILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN
DRETQSLDVIFTERQAITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDT
EYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCHGFHPE

--------------------------------------------------------------

>38441_38441_16_IFT74-CACNA2D3_IFT74_chr9_26990193_ENST00000443698_CACNA2D3_chr3_55038790_ENST00000490478_length(amino acids)=390AA_BP=196
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGVLSSQIKVAHRPVTQQGLTGMKTGTKGPQRQ
ILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN
DRETQSLDVIFTERQAITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDT
EYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCHGFHPE

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:26990193/chr3:55038790)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
IFT74 Q96LB3	CACNA2D3 Q8IZS8
FUNCTION: Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis. {ECO:0000269\|PubMed:23990561}.	FUNCTION: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

IFT74

chr9:26990193

chr3:55038790

ENST00000380062

1_90

195.66666666666666

601.0

Region

Note=Basic region

Hgene

IFT74

chr9:26990193

chr3:55038790

ENST00000429045

1_90

195.66666666666666

373.0

Region

Note=Basic region

Hgene

IFT74

chr9:26990193

chr3:55038790

ENST00000433700

1_90

195.66666666666666

601.0

Region

Note=Basic region

Hgene

IFT74

chr9:26990193

chr3:55038790

ENST00000443698

1_90

195.66666666666666

601.0

Region

Note=Basic region

Tgene

CACNA2D3

chr9:26990193

chr3:55038790

ENST00000288197

1090_1091

896.6666666666666

1092.0

Topological domain

Cytoplasmic

Tgene

CACNA2D3

chr9:26990193

chr3:55038790

ENST00000415676

1090_1091

896.6666666666666

1092.0

Topological domain

Cytoplasmic

Tgene

CACNA2D3

chr9:26990193

chr3:55038790

ENST00000474759

1090_1091

896.6666666666666

1092.0

Topological domain

Cytoplasmic

Tgene

CACNA2D3

chr9:26990193

chr3:55038790

ENST00000490478

1090_1091

802.6666666666666

998.0

Topological domain

Cytoplasmic

Tgene

CACNA2D3

chr9:26990193

chr3:55038790

ENST00000288197

1069_1089

896.6666666666666

1092.0

Transmembrane

Helical

Tgene

CACNA2D3

chr9:26990193

chr3:55038790

ENST00000415676

1069_1089

896.6666666666666

1092.0

Transmembrane

Helical

Tgene

CACNA2D3

chr9:26990193

chr3:55038790

ENST00000474759

1069_1089

896.6666666666666

1092.0

Transmembrane

Helical

Tgene

CACNA2D3

chr9:26990193

chr3:55038790

ENST00000490478

1069_1089

802.6666666666666

998.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

IFT74

chr9:26990193

chr3:55038790

ENST00000380062

98_482

195.66666666666666

601.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

IFT74

chr9:26990193

chr3:55038790

ENST00000429045

98_482

195.66666666666666

373.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

IFT74

chr9:26990193

chr3:55038790

ENST00000433700

98_482

195.66666666666666

601.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

IFT74

chr9:26990193

chr3:55038790

ENST00000443698

98_482

195.66666666666666

601.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CACNA2D3

chr9:26990193

chr3:55038790

ENST00000288197

256_438

896.6666666666666

1092.0

Domain

VWFA

Tgene

CACNA2D3

chr9:26990193

chr3:55038790

ENST00000288197

452_549

896.6666666666666

1092.0

Domain

Note=Cache

Tgene

CACNA2D3

chr9:26990193

chr3:55038790

ENST00000415676

256_438

896.6666666666666

1092.0

Domain

VWFA

Tgene

CACNA2D3

chr9:26990193

chr3:55038790

ENST00000415676

452_549

896.6666666666666

1092.0

Domain

Note=Cache

Tgene

CACNA2D3

chr9:26990193

chr3:55038790

ENST00000474759

256_438

896.6666666666666

1092.0

Domain

VWFA

Tgene

CACNA2D3

chr9:26990193

chr3:55038790

ENST00000474759

452_549

896.6666666666666

1092.0

Domain

Note=Cache

Tgene

CACNA2D3

chr9:26990193

chr3:55038790

ENST00000490478

256_438

802.6666666666666

998.0

Domain

VWFA

Tgene

CACNA2D3

chr9:26990193

chr3:55038790

ENST00000490478

452_549

802.6666666666666

998.0

Domain

Note=Cache

Tgene

CACNA2D3

chr9:26990193

chr3:55038790

ENST00000288197

262_266

896.6666666666666

1092.0

Motif

Note=MIDAS-like motif

Tgene

CACNA2D3

chr9:26990193

chr3:55038790

ENST00000415676

262_266

896.6666666666666

1092.0

Motif

Note=MIDAS-like motif

Tgene

CACNA2D3

chr9:26990193

chr3:55038790

ENST00000474759

262_266

896.6666666666666

1092.0

Motif

Note=MIDAS-like motif

Tgene

CACNA2D3

chr9:26990193

chr3:55038790

ENST00000490478

262_266

802.6666666666666

998.0

Motif

Note=MIDAS-like motif

Tgene

CACNA2D3

chr9:26990193

chr3:55038790

ENST00000288197

29_1068

896.6666666666666

1092.0

Topological domain

Extracellular

Tgene

CACNA2D3

chr9:26990193

chr3:55038790

ENST00000415676

29_1068

896.6666666666666

1092.0

Topological domain

Extracellular

Tgene

CACNA2D3

chr9:26990193

chr3:55038790

ENST00000474759

29_1068

896.6666666666666

1092.0

Topological domain

Extracellular

Tgene

CACNA2D3

chr9:26990193

chr3:55038790

ENST00000490478

29_1068

802.6666666666666

998.0

Topological domain

Extracellular

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
IFT74
CACNA2D3

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to IFT74-CACNA2D3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to IFT74-CACNA2D3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source