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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:IGF1R-ARID1B

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: IGF1R-ARID1B
	FusionPDB ID: 38471
	FusionGDB2.0 ID: 38471
		Hgene	Tgene
	Gene symbol	IGF1R	ARID1B
	Gene ID	3480	57492
	Gene name	insulin like growth factor 1 receptor	AT-rich interaction domain 1B
	Synonyms	CD221\|IGFIR\|IGFR\|JTK13	6A3-5\|BAF250B\|BRIGHT\|CSS1\|DAN15\|ELD/OSA1\|MRD12\|OSA2\|P250R
	Cytomap	15q26.3	6q25.3
	Type of gene	protein-coding	protein-coding
	Description	insulin-like growth factor 1 receptorIGF-I receptorsoluble IGF1R variant 1soluble IGF1R variant 2	AT-rich interactive domain-containing protein 1BARID domain-containing protein 1BAT rich interactive domain 1B (SWI1-like)BRG1-associated factor 250bBRG1-binding protein ELD/OSA1ELD (eyelid)/OSA protein
	Modification date	20200329	20200320
	UniProtAcc	P08069	Q8NFD5
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000268035, ENST00000558762, ENST00000560432,	ENST00000478761, ENST00000275248, ENST00000346085, ENST00000350026, ENST00000367148,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	24 X 15 X 6=2160	10 X 12 X 6=720
	# samples	25	12
	** MAII score	log2(25/2160*10)=-3.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/720*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: IGF1R [Title/Abstract] AND ARID1B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	IGF1R(99251336)-ARID1B(157469758), # samples:3
Anticipated loss of major functional domain due to fusion event.	IGF1R-ARID1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. IGF1R-ARID1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. IGF1R-ARID1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. IGF1R-ARID1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	IGF1R	GO:0043066	negative regulation of apoptotic process	12556535
Hgene	IGF1R	GO:0046328	regulation of JNK cascade	12556535
Hgene	IGF1R	GO:0046777	protein autophosphorylation	1846292\|7679099\|11162456
Hgene	IGF1R	GO:0048009	insulin-like growth factor receptor signaling pathway	7679099
Hgene	IGF1R	GO:0048015	phosphatidylinositol-mediated signaling	7692086
Hgene	IGF1R	GO:0051389	inactivation of MAPKK activity	12556535

Fusion gene breakpoints across IGF1R (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ARID1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-E9-A1NF-01A	IGF1R	chr15	99251336	-	ARID1B	chr6	157469758	+
ChimerDB4	BRCA	TCGA-E9-A1NF-01A	IGF1R	chr15	99251336	+	ARID1B	chr6	157469758	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000268035	IGF1R	chr15	99251336	+	ENST00000350026	ARID1B	chr6	157469758	+	6709	1251	611	5449	1612
ENST00000268035	IGF1R	chr15	99251336	+	ENST00000346085	ARID1B	chr6	157469758	+	8338	1251	611	5449	1612
ENST00000268035	IGF1R	chr15	99251336	+	ENST00000367148	ARID1B	chr6	157469758	+	6985	1251	611	5608	1665
ENST00000268035	IGF1R	chr15	99251336	+	ENST00000275248	ARID1B	chr6	157469758	+	6985	1251	611	5608	1665
ENST00000558762	IGF1R	chr15	99251336	+	ENST00000350026	ARID1B	chr6	157469758	+	6636	1178	538	5376	1612
ENST00000558762	IGF1R	chr15	99251336	+	ENST00000346085	ARID1B	chr6	157469758	+	8265	1178	538	5376	1612
ENST00000558762	IGF1R	chr15	99251336	+	ENST00000367148	ARID1B	chr6	157469758	+	6912	1178	538	5535	1665
ENST00000558762	IGF1R	chr15	99251336	+	ENST00000275248	ARID1B	chr6	157469758	+	6912	1178	538	5535	1665

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000268035	ENST00000350026	IGF1R	chr15	99251336	+	ARID1B	chr6	157469758	+	0.002961082	0.99703896
ENST00000268035	ENST00000346085	IGF1R	chr15	99251336	+	ARID1B	chr6	157469758	+	0.001095424	0.9989046
ENST00000268035	ENST00000367148	IGF1R	chr15	99251336	+	ARID1B	chr6	157469758	+	0.002819619	0.99718034
ENST00000268035	ENST00000275248	IGF1R	chr15	99251336	+	ARID1B	chr6	157469758	+	0.002819619	0.99718034
ENST00000558762	ENST00000350026	IGF1R	chr15	99251336	+	ARID1B	chr6	157469758	+	0.002691637	0.9973084
ENST00000558762	ENST00000346085	IGF1R	chr15	99251336	+	ARID1B	chr6	157469758	+	0.001014489	0.99898547
ENST00000558762	ENST00000367148	IGF1R	chr15	99251336	+	ARID1B	chr6	157469758	+	0.002552976	0.997447
ENST00000558762	ENST00000275248	IGF1R	chr15	99251336	+	ARID1B	chr6	157469758	+	0.002552976	0.997447

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>38471_38471_1_IGF1R-ARID1B_IGF1R_chr15_99251336_ENST00000268035_ARID1B_chr6_157469758_ENST00000275248_length(amino acids)=1665AA_BP=214
MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRV
AGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGD
LCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKSNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNR
PFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPY
SMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSIS
SPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRE
LATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPT
PASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNS
SMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNM
QYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGP
TQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPF
LPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYD
DSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEK
TESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRR
RPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTI
AHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNT
LVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYAT
LVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLA

--------------------------------------------------------------

>38471_38471_2_IGF1R-ARID1B_IGF1R_chr15_99251336_ENST00000268035_ARID1B_chr6_157469758_ENST00000346085_length(amino acids)=1612AA_BP=214
MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRV
AGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGD
LCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKSNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNR
PFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPY
SMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPV
SSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPK
LQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMP
DVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPP
YGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQM
MGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQ
PSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKIT
SKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAAR
KDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLG
RVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQ
TESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPE
RKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLS
PQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGV

--------------------------------------------------------------

>38471_38471_3_IGF1R-ARID1B_IGF1R_chr15_99251336_ENST00000268035_ARID1B_chr6_157469758_ENST00000350026_length(amino acids)=1612AA_BP=214
MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRV
AGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGD
LCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKSNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNR
PFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPY
SMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPV
SSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPK
LQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMP
DVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPP
YGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQM
MGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQ
PSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKIT
SKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAAR
KDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLG
RVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQ
TESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPE
RKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLS
PQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGV

--------------------------------------------------------------

>38471_38471_4_IGF1R-ARID1B_IGF1R_chr15_99251336_ENST00000268035_ARID1B_chr6_157469758_ENST00000367148_length(amino acids)=1665AA_BP=214
MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRV
AGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGD
LCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKSNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNR
PFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPY
SMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSIS
SPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRE
LATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPT
PASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNS
SMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNM
QYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGP
TQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPF
LPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYD
DSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEK
TESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRR
RPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTI
AHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNT
LVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYAT
LVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLA

--------------------------------------------------------------

>38471_38471_5_IGF1R-ARID1B_IGF1R_chr15_99251336_ENST00000558762_ARID1B_chr6_157469758_ENST00000275248_length(amino acids)=1665AA_BP=214
MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRV
AGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGD
LCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKSNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNR
PFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPY
SMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSIS
SPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRE
LATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPT
PASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNS
SMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNM
QYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGP
TQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPF
LPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYD
DSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEK
TESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRR
RPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTI
AHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNT
LVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYAT
LVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLA

--------------------------------------------------------------

>38471_38471_6_IGF1R-ARID1B_IGF1R_chr15_99251336_ENST00000558762_ARID1B_chr6_157469758_ENST00000346085_length(amino acids)=1612AA_BP=214
MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRV
AGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGD
LCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKSNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNR
PFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPY
SMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPV
SSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPK
LQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMP
DVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPP
YGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQM
MGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQ
PSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKIT
SKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAAR
KDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLG
RVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQ
TESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPE
RKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLS
PQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGV

--------------------------------------------------------------

>38471_38471_7_IGF1R-ARID1B_IGF1R_chr15_99251336_ENST00000558762_ARID1B_chr6_157469758_ENST00000350026_length(amino acids)=1612AA_BP=214
MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRV
AGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGD
LCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKSNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNR
PFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPY
SMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPV
SSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPK
LQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMP
DVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPP
YGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQM
MGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQ
PSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKIT
SKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAAR
KDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLG
RVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQ
TESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPE
RKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLS
PQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGV

--------------------------------------------------------------

>38471_38471_8_IGF1R-ARID1B_IGF1R_chr15_99251336_ENST00000558762_ARID1B_chr6_157469758_ENST00000367148_length(amino acids)=1665AA_BP=214
MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRV
AGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGD
LCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKSNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNR
PFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPY
SMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSIS
SPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRE
LATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPT
PASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNS
SMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNM
QYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGP
TQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPF
LPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYD
DSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEK
TESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRR
RPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTI
AHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNT
LVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYAT
LVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLA

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:99251336/chr6:157469758)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
IGF1R P08069	ARID1B Q8NFD5
FUNCTION: Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R.; FUNCTION: When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.	FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically (PubMed:14982958, PubMed:15170388). {ECO:0000250\|UniProtKB:E9Q4N7, ECO:0000269\|PubMed:14982958, ECO:0000269\|PubMed:15170388, ECO:0000303\|PubMed:12672490, ECO:0000303\|PubMed:22952240, ECO:0000303\|PubMed:26601204}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000346085

1034_1037

850.3333333333334

2250.0

Compositional bias

Note=Poly-Ser

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000346085

1441_1444

850.3333333333334

2250.0

Compositional bias

Note=Poly-Ser

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000346085

1459_1597

850.3333333333334

2250.0

Compositional bias

Note=Pro-rich

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000346085

1833_1836

850.3333333333334

2250.0

Compositional bias

Note=Poly-Pro

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000346085

932_935

850.3333333333334

2250.0

Compositional bias

Note=Poly-Ala

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000350026

1034_1037

837.3333333333334

2237.0

Compositional bias

Note=Poly-Ser

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000350026

1441_1444

837.3333333333334

2237.0

Compositional bias

Note=Poly-Ser

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000350026

1459_1597

837.3333333333334

2237.0

Compositional bias

Note=Pro-rich

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000350026

1833_1836

837.3333333333334

2237.0

Compositional bias

Note=Poly-Pro

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000350026

932_935

837.3333333333334

2237.0

Compositional bias

Note=Poly-Ala

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000367148

1034_1037

837.3333333333334

2290.0

Compositional bias

Note=Poly-Ser

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000367148

1441_1444

837.3333333333334

2290.0

Compositional bias

Note=Poly-Ser

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000367148

1459_1597

837.3333333333334

2290.0

Compositional bias

Note=Pro-rich

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000367148

1833_1836

837.3333333333334

2290.0

Compositional bias

Note=Poly-Pro

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000367148

932_935

837.3333333333334

2290.0

Compositional bias

Note=Poly-Ala

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000346085

1053_1144

850.3333333333334

2250.0

Domain

ARID

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000350026

1053_1144

837.3333333333334

2237.0

Domain

ARID

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000367148

1053_1144

837.3333333333334

2290.0

Domain

ARID

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000346085

1358_1377

850.3333333333334

2250.0

Motif

Nuclear localization signal

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000346085

2036_2040

850.3333333333334

2250.0

Motif

Note=LXXLL

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000350026

1358_1377

837.3333333333334

2237.0

Motif

Nuclear localization signal

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000350026

2036_2040

837.3333333333334

2237.0

Motif

Note=LXXLL

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000367148

1358_1377

837.3333333333334

2290.0

Motif

Nuclear localization signal

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000367148

2036_2040

837.3333333333334

2290.0

Motif

Note=LXXLL

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

IGF1R

chr15:99251336

chr6:157469758

ENST00000268035

491_609

213.33333333333334

1368.0

Domain

Fibronectin type-III 1

Hgene

IGF1R

chr15:99251336

chr6:157469758

ENST00000268035

610_708

213.33333333333334

1368.0

Domain

Fibronectin type-III 2

Hgene

IGF1R

chr15:99251336

chr6:157469758

ENST00000268035

735_828

213.33333333333334

1368.0

Domain

Fibronectin type-III 3

Hgene

IGF1R

chr15:99251336

chr6:157469758

ENST00000268035

834_927

213.33333333333334

1368.0

Domain

Fibronectin type-III 4

Hgene

IGF1R

chr15:99251336

chr6:157469758

ENST00000268035

999_1274

213.33333333333334

1368.0

Domain

Protein kinase

Hgene

IGF1R

chr15:99251336

chr6:157469758

ENST00000268035

977_980

213.33333333333334

1368.0

Motif

Note=IRS1- and SHC1-binding

Hgene

IGF1R

chr15:99251336

chr6:157469758

ENST00000268035

1005_1013

213.33333333333334

1368.0

Nucleotide binding

ATP

Hgene

IGF1R

chr15:99251336

chr6:157469758

ENST00000268035

741_935

213.33333333333334

1368.0

Topological domain

Extracellular

Hgene

IGF1R

chr15:99251336

chr6:157469758

ENST00000268035

960_1367

213.33333333333334

1368.0

Topological domain

Cytoplasmic

Hgene

IGF1R

chr15:99251336

chr6:157469758

ENST00000268035

936_959

213.33333333333334

1368.0

Transmembrane

Helical

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000346085

107_131

850.3333333333334

2250.0

Compositional bias

Note=Gln-rich

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000346085

114_131

850.3333333333334

2250.0

Compositional bias

Note=Poly-Gln

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000346085

141_401

850.3333333333334

2250.0

Compositional bias

Note=Gly-rich

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000346085

2_47

850.3333333333334

2250.0

Compositional bias

Note=Ala-rich

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000346085

329_493

850.3333333333334

2250.0

Compositional bias

Note=Ala-rich

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000346085

35_57

850.3333333333334

2250.0

Compositional bias

Note=Ser-rich

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000346085

574_633

850.3333333333334

2250.0

Compositional bias

Note=Gln-rich

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000346085

684_771

850.3333333333334

2250.0

Compositional bias

Note=Ser-rich

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000346085

81_104

850.3333333333334

2250.0

Compositional bias

Note=His-rich

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000350026

107_131

837.3333333333334

2237.0

Compositional bias

Note=Gln-rich

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000350026

114_131

837.3333333333334

2237.0

Compositional bias

Note=Poly-Gln

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000350026

141_401

837.3333333333334

2237.0

Compositional bias

Note=Gly-rich

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000350026

2_47

837.3333333333334

2237.0

Compositional bias

Note=Ala-rich

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000350026

329_493

837.3333333333334

2237.0

Compositional bias

Note=Ala-rich

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000350026

35_57

837.3333333333334

2237.0

Compositional bias

Note=Ser-rich

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000350026

574_633

837.3333333333334

2237.0

Compositional bias

Note=Gln-rich

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000350026

684_771

837.3333333333334

2237.0

Compositional bias

Note=Ser-rich

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000350026

81_104

837.3333333333334

2237.0

Compositional bias

Note=His-rich

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000367148

107_131

837.3333333333334

2290.0

Compositional bias

Note=Gln-rich

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000367148

114_131

837.3333333333334

2290.0

Compositional bias

Note=Poly-Gln

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000367148

141_401

837.3333333333334

2290.0

Compositional bias

Note=Gly-rich

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000367148

2_47

837.3333333333334

2290.0

Compositional bias

Note=Ala-rich

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000367148

329_493

837.3333333333334

2290.0

Compositional bias

Note=Ala-rich

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000367148

35_57

837.3333333333334

2290.0

Compositional bias

Note=Ser-rich

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000367148

574_633

837.3333333333334

2290.0

Compositional bias

Note=Gln-rich

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000367148

684_771

837.3333333333334

2290.0

Compositional bias

Note=Ser-rich

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000367148

81_104

837.3333333333334

2290.0

Compositional bias

Note=His-rich

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000346085

419_423

850.3333333333334

2250.0

Motif

Note=LXXLL

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000350026

419_423

837.3333333333334

2237.0

Motif

Note=LXXLL

Tgene

ARID1B

chr15:99251336

chr6:157469758

ENST00000367148

419_423

837.3333333333334

2290.0

Motif

Note=LXXLL

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
IGF1R
ARID1B

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to IGF1R-ARID1B

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to IGF1R-ARID1B

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source