UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:IGF2R-QKI

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: IGF2R-QKI
FusionPDB ID: 38548
FusionGDB2.0 ID: 38548
HgeneTgene
Gene symbol

IGF2R

QKI

Gene ID

3482

9444

Gene nameinsulin like growth factor 2 receptorQKI, KH domain containing RNA binding
SynonymsCD222|CI-M6PR|CIMPR|M6P-R|M6P/IGF2R|MPR 300|MPR1|MPR300|MPRIHqk|QK|QK1|QK3|hqkI
Cytomap

6q25.3

6q26

Type of geneprotein-codingprotein-coding
Descriptioncation-independent mannose-6-phosphate receptor300 kDa mannose 6-phosphate receptorCI Man-6-P receptorIGF-II receptorM6P/IGF2 receptorinsulin-like growth factor II receptorprotein quakingQKI/LOC100132735 fusionRNA binding protein HQKhomolog of mouse quaking QKI (KH domain RNA binding protein)quaking homolog, KH domain RNA binding
Modification date2020031520200327
UniProtAcc

P11717

Q96PU8

Ensembl transtripts involved in fusion geneENST idsENST00000356956, ENST00000475584, 
ENST00000275262, ENST00000361195, 
ENST00000361752, ENST00000392127, 
ENST00000424802, ENST00000453779, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score23 X 16 X 11=404823 X 23 X 9=4761
# samples 2527
** MAII scorelog2(25/4048*10)=-4.01720929003222
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/4761*10)=-4.14023331650551
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: IGF2R [Title/Abstract] AND QKI [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)IGF2R(160412355)-QKI(163876311), # samples:1
IGF2R(160511135)-QKI(163956014), # samples:1
Anticipated loss of major functional domain due to fusion event.IGF2R-QKI seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
IGF2R-QKI seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
IGF2R-QKI seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
IGF2R-QKI seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
IGF2R-QKI seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
IGF2R-QKI seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
IGF2R-QKI seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across IGF2R (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across QKI (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EE-A29G-06AIGF2Rchr6

160511135

-QKIchr6

163956014

+
ChimerDB4STADTCGA-CD-8531-01AIGF2Rchr6

160412355

+QKIchr6

163876311

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356956IGF2Rchr6160412355+ENST00000275262QKIchr6163876311+6708437611272403
ENST00000356956IGF2Rchr6160412355+ENST00000392127QKIchr6163876311+7655437611254397
ENST00000356956IGF2Rchr6160412355+ENST00000453779QKIchr6163876311+5429437611254397
ENST00000356956IGF2Rchr6160412355+ENST00000361752QKIchr6163876311+9207437611320419
ENST00000356956IGF2Rchr6160412355+ENST00000361195QKIchr6163876311+1334437611296411
ENST00000356956IGF2Rchr6160412355+ENST00000424802QKIchr6163876311+1249437611248396

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356956ENST00000275262IGF2Rchr6160412355+QKIchr6163876311+0.0001905290.99980944
ENST00000356956ENST00000392127IGF2Rchr6160412355+QKIchr6163876311+0.0001675760.9998324
ENST00000356956ENST00000453779IGF2Rchr6160412355+QKIchr6163876311+0.0001678910.99983203
ENST00000356956ENST00000361752IGF2Rchr6160412355+QKIchr6163876311+0.0001750360.99982494
ENST00000356956ENST00000361195IGF2Rchr6160412355+QKIchr6163876311+0.0064287680.9935713
ENST00000356956ENST00000424802IGF2Rchr6160412355+QKIchr6163876311+0.0044130890.9955869

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>38548_38548_1_IGF2R-QKI_IGF2R_chr6_160412355_ENST00000356956_QKI_chr6_163876311_ENST00000275262_length(amino acids)=403AA_BP=125
MAARPRPGRGPQQSRAVSLAPAAQSGPGAMGAAAGRSPHLGPAPARRPQRSLLLLQLLLLVAAPGSTQAQAAPFPELCSYTWEAVDTKNN
VLYKINICGSVDIVQCGPSSAVCMHDLKTRTYHSVEISRVRKDMYNDTLNGSTEKRSAELPDAVGPIVQLQEKLYVPVKEYPDFNFVGRI
LGPRGLTAKQLEAETGCKIMVRGKGSMRDKKKEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKM
QLMELAILNGTYRDANIKSPALAFSLAATAQAAPRIITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAG

--------------------------------------------------------------

>38548_38548_2_IGF2R-QKI_IGF2R_chr6_160412355_ENST00000356956_QKI_chr6_163876311_ENST00000361195_length(amino acids)=411AA_BP=125
MAARPRPGRGPQQSRAVSLAPAAQSGPGAMGAAAGRSPHLGPAPARRPQRSLLLLQLLLLVAAPGSTQAQAAPFPELCSYTWEAVDTKNN
VLYKINICGSVDIVQCGPSSAVCMHDLKTRTYHSVEISRVRKDMYNDTLNGSTEKRSAELPDAVGPIVQLQEKLYVPVKEYPDFNFVGRI
LGPRGLTAKQLEAETGCKIMVRGKGSMRDKKKEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKM
QLMELAILNGTYRDANIKSPTAQAAPRIITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAGLIYTPYEY

--------------------------------------------------------------

>38548_38548_3_IGF2R-QKI_IGF2R_chr6_160412355_ENST00000356956_QKI_chr6_163876311_ENST00000361752_length(amino acids)=419AA_BP=125
MAARPRPGRGPQQSRAVSLAPAAQSGPGAMGAAAGRSPHLGPAPARRPQRSLLLLQLLLLVAAPGSTQAQAAPFPELCSYTWEAVDTKNN
VLYKINICGSVDIVQCGPSSAVCMHDLKTRTYHSVEISRVRKDMYNDTLNGSTEKRSAELPDAVGPIVQLQEKLYVPVKEYPDFNFVGRI
LGPRGLTAKQLEAETGCKIMVRGKGSMRDKKKEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKM
QLMELAILNGTYRDANIKSPALAFSLAATAQAAPRIITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAG

--------------------------------------------------------------

>38548_38548_4_IGF2R-QKI_IGF2R_chr6_160412355_ENST00000356956_QKI_chr6_163876311_ENST00000392127_length(amino acids)=397AA_BP=125
MAARPRPGRGPQQSRAVSLAPAAQSGPGAMGAAAGRSPHLGPAPARRPQRSLLLLQLLLLVAAPGSTQAQAAPFPELCSYTWEAVDTKNN
VLYKINICGSVDIVQCGPSSAVCMHDLKTRTYHSVEISRVRKDMYNDTLNGSTEKRSAELPDAVGPIVQLQEKLYVPVKEYPDFNFVGRI
LGPRGLTAKQLEAETGCKIMVRGKGSMRDKKKEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKM
QLMELAILNGTYRDANIKSPALAFSLAATAQAAPRIITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAG

--------------------------------------------------------------

>38548_38548_5_IGF2R-QKI_IGF2R_chr6_160412355_ENST00000356956_QKI_chr6_163876311_ENST00000424802_length(amino acids)=396AA_BP=125
MAARPRPGRGPQQSRAVSLAPAAQSGPGAMGAAAGRSPHLGPAPARRPQRSLLLLQLLLLVAAPGSTQAQAAPFPELCSYTWEAVDTKNN
VLYKINICGSVDIVQCGPSSAVCMHDLKTRTYHSVEISRVRKDMYNDTLNGSTEKRSAELPDAVGPIVQLQEKLYVPVKEYPDFNFVGRI
LGPRGLTAKQLEAETGCKIMVRGKGSMRDKKKEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKM
QLMELAILNGTYRDANIKSPTAQAAPRIITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAGLIYTPYEY

--------------------------------------------------------------

>38548_38548_6_IGF2R-QKI_IGF2R_chr6_160412355_ENST00000356956_QKI_chr6_163876311_ENST00000453779_length(amino acids)=397AA_BP=125
MAARPRPGRGPQQSRAVSLAPAAQSGPGAMGAAAGRSPHLGPAPARRPQRSLLLLQLLLLVAAPGSTQAQAAPFPELCSYTWEAVDTKNN
VLYKINICGSVDIVQCGPSSAVCMHDLKTRTYHSVEISRVRKDMYNDTLNGSTEKRSAELPDAVGPIVQLQEKLYVPVKEYPDFNFVGRI
LGPRGLTAKQLEAETGCKIMVRGKGSMRDKKKEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKM
QLMELAILNGTYRDANIKSPALAFSLAATAQAAPRIITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAG

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:160412355/chr6:163876311)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IGF2R

P11717

QKI

Q96PU8

FUNCTION: Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:2963003, PubMed:18817523). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:2963003, PubMed:18817523). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523). This receptor also binds IGF2 (PubMed:18046459). Acts as a positive regulator of T-cell coactivation by binding DPP4 (PubMed:10900005). {ECO:0000269|PubMed:10900005, ECO:0000269|PubMed:18046459, ECO:0000269|PubMed:18817523, ECO:0000269|PubMed:2963003}.FUNCTION: RNA-binding protein that plays a central role in myelinization (PubMed:16641098). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077). In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098). Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity). {ECO:0000250|UniProtKB:Q9QYS9, ECO:0000269|PubMed:16641098, ECO:0000269|PubMed:23630077}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneQKIchr6:160412355chr6:163876311ENST000002752620787_15347.333333333333336326.0DomainNote=KH
TgeneQKIchr6:160412355chr6:163876311ENST000003611950887_15347.333333333333336334.0DomainNote=KH
TgeneQKIchr6:160412355chr6:163876311ENST000003617520887_15347.333333333333336342.0DomainNote=KH
TgeneQKIchr6:160412355chr6:163876311ENST000003921270687_15347.333333333333336320.0DomainNote=KH
TgeneQKIchr6:160412355chr6:163876311ENST000004248020787_15347.333333333333336318.0DomainNote=KH
TgeneQKIchr6:160412355chr6:163876311ENST000004537790787_15347.333333333333336320.0DomainNote=KH
TgeneQKIchr6:160412355chr6:163876311ENST0000027526207276_27947.333333333333336326.0MotifNote=SH3-binding
TgeneQKIchr6:160412355chr6:163876311ENST0000027526207324_33047.333333333333336326.0MotifNuclear localization signal
TgeneQKIchr6:160412355chr6:163876311ENST0000036119508276_27947.333333333333336334.0MotifNote=SH3-binding
TgeneQKIchr6:160412355chr6:163876311ENST0000036119508324_33047.333333333333336334.0MotifNuclear localization signal
TgeneQKIchr6:160412355chr6:163876311ENST0000036175208276_27947.333333333333336342.0MotifNote=SH3-binding
TgeneQKIchr6:160412355chr6:163876311ENST0000036175208324_33047.333333333333336342.0MotifNuclear localization signal
TgeneQKIchr6:160412355chr6:163876311ENST0000039212706276_27947.333333333333336320.0MotifNote=SH3-binding
TgeneQKIchr6:160412355chr6:163876311ENST0000039212706324_33047.333333333333336320.0MotifNuclear localization signal
TgeneQKIchr6:160412355chr6:163876311ENST0000042480207276_27947.333333333333336318.0MotifNote=SH3-binding
TgeneQKIchr6:160412355chr6:163876311ENST0000042480207324_33047.333333333333336318.0MotifNuclear localization signal
TgeneQKIchr6:160412355chr6:163876311ENST0000045377907276_27947.333333333333336320.0MotifNote=SH3-binding
TgeneQKIchr6:160412355chr6:163876311ENST0000045377907324_33047.333333333333336320.0MotifNuclear localization signal
TgeneQKIchr6:160412355chr6:163876311ENST0000027526207182_21347.333333333333336326.0RegionQua2 domain%3B involved in RNA binding
TgeneQKIchr6:160412355chr6:163876311ENST0000036119508182_21347.333333333333336334.0RegionQua2 domain%3B involved in RNA binding
TgeneQKIchr6:160412355chr6:163876311ENST0000036175208182_21347.333333333333336342.0RegionQua2 domain%3B involved in RNA binding
TgeneQKIchr6:160412355chr6:163876311ENST0000039212706182_21347.333333333333336320.0RegionQua2 domain%3B involved in RNA binding
TgeneQKIchr6:160412355chr6:163876311ENST0000042480207182_21347.333333333333336318.0RegionQua2 domain%3B involved in RNA binding
TgeneQKIchr6:160412355chr6:163876311ENST0000045377907182_21347.333333333333336320.0RegionQua2 domain%3B involved in RNA binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIGF2Rchr6:160412355chr6:163876311ENST00000356956+2481082_121996.333333333333332492.0DomainMRH 8
HgeneIGF2Rchr6:160412355chr6:163876311ENST00000356956+2481225_136396.333333333333332492.0DomainMRH 9
HgeneIGF2Rchr6:160412355chr6:163876311ENST00000356956+2481367_150896.333333333333332492.0DomainMRH 10
HgeneIGF2Rchr6:160412355chr6:163876311ENST00000356956+2481514_164896.333333333333332492.0DomainMRH 11
HgeneIGF2Rchr6:160412355chr6:163876311ENST00000356956+2481650_179796.333333333333332492.0DomainMRH 12
HgeneIGF2Rchr6:160412355chr6:163876311ENST00000356956+248172_32096.333333333333332492.0DomainMRH 2
HgeneIGF2Rchr6:160412355chr6:163876311ENST00000356956+2481802_198996.333333333333332492.0DomainFibronectin type-II
HgeneIGF2Rchr6:160412355chr6:163876311ENST00000356956+2481992_212796.333333333333332492.0DomainMRH 14
HgeneIGF2Rchr6:160412355chr6:163876311ENST00000356956+2482135_228096.333333333333332492.0DomainMRH 15
HgeneIGF2Rchr6:160412355chr6:163876311ENST00000356956+248326_46896.333333333333332492.0DomainMRH 3
HgeneIGF2Rchr6:160412355chr6:163876311ENST00000356956+248473_61996.333333333333332492.0DomainMRH 4
HgeneIGF2Rchr6:160412355chr6:163876311ENST00000356956+24847_16396.333333333333332492.0DomainMRH 1
HgeneIGF2Rchr6:160412355chr6:163876311ENST00000356956+248625_76296.333333333333332492.0DomainMRH 5
HgeneIGF2Rchr6:160412355chr6:163876311ENST00000356956+248765_92496.333333333333332492.0DomainMRH 6
HgeneIGF2Rchr6:160412355chr6:163876311ENST00000356956+248932_107996.333333333333332492.0DomainMRH 7
HgeneIGF2Rchr6:160412355chr6:163876311ENST00000356956+2482328_249196.333333333333332492.0Topological domainCytoplasmic
HgeneIGF2Rchr6:160412355chr6:163876311ENST00000356956+24841_230496.333333333333332492.0Topological domainLumenal
HgeneIGF2Rchr6:160412355chr6:163876311ENST00000356956+2482305_232796.333333333333332492.0TransmembraneHelical
TgeneQKIchr6:160412355chr6:163876311ENST000002752620711_8247.333333333333336326.0RegionQua1 domain%3B involved in homodimerization
TgeneQKIchr6:160412355chr6:163876311ENST000003611950811_8247.333333333333336334.0RegionQua1 domain%3B involved in homodimerization
TgeneQKIchr6:160412355chr6:163876311ENST000003617520811_8247.333333333333336342.0RegionQua1 domain%3B involved in homodimerization
TgeneQKIchr6:160412355chr6:163876311ENST000003921270611_8247.333333333333336320.0RegionQua1 domain%3B involved in homodimerization
TgeneQKIchr6:160412355chr6:163876311ENST000004248020711_8247.333333333333336318.0RegionQua1 domain%3B involved in homodimerization
TgeneQKIchr6:160412355chr6:163876311ENST000004537790711_8247.333333333333336320.0RegionQua1 domain%3B involved in homodimerization


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
QKIHNRNPK, USP30, MED12, MED13, MED25, MED16, MED17, MED1, MED24, MED23, MED4, MED29, MED31, MED15, MED14, MED26, MED10, POLR2A, MED27, ELAVL1, PSMF1, C10orf10, FUBP3, HCLS1, PCBP2, PTBP1, PTBP2, RBM14, RBFOX2, RBPMS, RNF138, SERF2, THAP1, USH1C, RBFOX1, PCBP1, PCBP4, APP, NDUFA7, CDV3, ATXN1, FN1, U2AF2, RBM23, RALY, WDR77, HNRNPH2, QKI, DAZ1, IL7R, CARM1, SNRPA, RBM11, NABP1, HNRNPLL, OIP5, RBMX, ZACN, CYP1A1, NTRK1, EWSR1, HYPK, DUSP22, DUSP4, ATE1, RBM42, FBXW11, SLC39A12, VAC14, TRIM11, SYNCRIP, SNRNP27, TAE1, PBP2, FBXO7, DMRTB1, CDKN2D, CCND3, TSG101, LSM3, TEX11, PIAS1, FHL3, ESR2, RAF1, APEX1, SNRNP70, DUSP14, LMBR1L, PRKAB2, TIAL1, E7, MIR7-1, MIR19B2, MIR34B, MIR34C, MIR141, MIR200A, CELF1, RBM47, RBMS1, C8orf82, RBM45, UFL1, DDRGK1, HNRNPA1, FZR1, HSPA2, HSPA1A, RBMS2, CYB5B, PRR3, CENPM, HNRNPUL2, FAM120A, HNRNPC, BAG1, IL7, TGM1, ELAVL2, BAG2, HSPA8, HNRNPCL2, HNRNPCL1, EIF4ENIF1, MBNL1, PCBP3, ALG13, YTHDF1, SNRPC, UNKL, BAG4, PRRC2B, MSI2, TNRC6A, ANKHD1, TXNL4A, CALD1, RBM7, ZMAT5, CCDC59, BCAS2, NXF1, TRNAU1AP, YTHDF3, NIP7, ZC3H10, CPSF7, SLAIN1, SECISBP2, RPL9, PRPF6, PRPF39, MBNL2, PCGF5, KIF21B, MRPL44, LSM5, UTP6, Pcbp1, Hnrnpk, Rbm38, Rbm47, Dusp14, Mrpl13, Ywhag, Pum2, Pef1, Hsp90aa1, GATA3, PAX9, SP7,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
IGF2R
QKIall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to IGF2R-QKI


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to IGF2R-QKI


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneQKIC0036341Schizophrenia5PSYGENET
TgeneQKIC0017638Glioma1CTD_human
TgeneQKIC0041696Unipolar Depression1PSYGENET
TgeneQKIC0259783mixed gliomas1CTD_human
TgeneQKIC0555198Malignant Glioma1CTD_human
TgeneQKIC1269683Major Depressive Disorder1PSYGENET
TgeneQKIC2363903Angiocentric glioma1ORPHANET
TgeneQKIC3714756Intellectual Disability1GENOMICS_ENGLAND