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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:IGFBP7-SPATA22

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: IGFBP7-SPATA22
	FusionPDB ID: 38621
	FusionGDB2.0 ID: 38621
		Hgene	Tgene
	Gene symbol	IGFBP7	SPATA22
	Gene ID	3490	84690
	Gene name	insulin like growth factor binding protein 7	spermatogenesis associated 22
	Synonyms	AGM\|FSTL2\|IBP-7\|IGFBP-7\|IGFBP-7v\|IGFBPRP1\|MAC25\|PSF\|RAMSVPS\|TAF	NYD-SP20\|NYDSP20
	Cytomap	4q12	17p13.2
	Type of gene	protein-coding	protein-coding
	Description	insulin-like growth factor-binding protein 7IGF-binding protein 7IGFBP-rP1PGI2-stimulating factorangiomodulinprostacyclin-stimulating factortumor-derived adhesion factor	spermatogenesis-associated protein 22testicular tissue protein Li 186testis development protein NYD-SP20
	Modification date	20200313	20200313
	UniProtAcc	Q16270	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000512512, ENST00000295666, ENST00000537922,	ENST00000268981, ENST00000355380, ENST00000397168, ENST00000541913, ENST00000572969, ENST00000573128, ENST00000575375,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	12 X 11 X 4=528	4 X 4 X 3=48
	# samples	11	4
	** MAII score	log2(11/528*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: IGFBP7 [Title/Abstract] AND SPATA22 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	IGFBP7(57906990)-SPATA22(3349895), # samples:2
Anticipated loss of major functional domain due to fusion event.	IGFBP7-SPATA22 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. IGFBP7-SPATA22 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. IGFBP7-SPATA22 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. IGFBP7-SPATA22 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	IGFBP7	GO:0007155	cell adhesion	8117260

Fusion gene breakpoints across IGFBP7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SPATA22 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-ER-A197-06A	IGFBP7	chr4	57906990	-	SPATA22	chr17	3349895	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000295666	IGFBP7	chr4	57906990	-	ENST00000541913	SPATA22	chr17	3349895	-	1164	619	10	1038	342
ENST00000295666	IGFBP7	chr4	57906990	-	ENST00000397168	SPATA22	chr17	3349895	-	1167	619	10	1038	342
ENST00000295666	IGFBP7	chr4	57906990	-	ENST00000572969	SPATA22	chr17	3349895	-	1167	619	10	1038	342
ENST00000295666	IGFBP7	chr4	57906990	-	ENST00000355380	SPATA22	chr17	3349895	-	1167	619	10	1038	342
ENST00000295666	IGFBP7	chr4	57906990	-	ENST00000575375	SPATA22	chr17	3349895	-	1167	619	10	1038	342
ENST00000295666	IGFBP7	chr4	57906990	-	ENST00000573128	SPATA22	chr17	3349895	-	1167	619	10	1038	342
ENST00000295666	IGFBP7	chr4	57906990	-	ENST00000268981	SPATA22	chr17	3349895	-	845	619	10	756	248
ENST00000537922	IGFBP7	chr4	57906990	-	ENST00000541913	SPATA22	chr17	3349895	-	1164	619	10	1038	342
ENST00000537922	IGFBP7	chr4	57906990	-	ENST00000397168	SPATA22	chr17	3349895	-	1167	619	10	1038	342
ENST00000537922	IGFBP7	chr4	57906990	-	ENST00000572969	SPATA22	chr17	3349895	-	1167	619	10	1038	342
ENST00000537922	IGFBP7	chr4	57906990	-	ENST00000355380	SPATA22	chr17	3349895	-	1167	619	10	1038	342
ENST00000537922	IGFBP7	chr4	57906990	-	ENST00000575375	SPATA22	chr17	3349895	-	1167	619	10	1038	342
ENST00000537922	IGFBP7	chr4	57906990	-	ENST00000573128	SPATA22	chr17	3349895	-	1167	619	10	1038	342
ENST00000537922	IGFBP7	chr4	57906990	-	ENST00000268981	SPATA22	chr17	3349895	-	845	619	10	756	248

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000295666	ENST00000541913	IGFBP7	chr4	57906990	-	SPATA22	chr17	3349895	-	0.003339137	0.9966608
ENST00000295666	ENST00000397168	IGFBP7	chr4	57906990	-	SPATA22	chr17	3349895	-	0.003038446	0.99696153
ENST00000295666	ENST00000572969	IGFBP7	chr4	57906990	-	SPATA22	chr17	3349895	-	0.003038446	0.99696153
ENST00000295666	ENST00000355380	IGFBP7	chr4	57906990	-	SPATA22	chr17	3349895	-	0.003038446	0.99696153
ENST00000295666	ENST00000575375	IGFBP7	chr4	57906990	-	SPATA22	chr17	3349895	-	0.003038446	0.99696153
ENST00000295666	ENST00000573128	IGFBP7	chr4	57906990	-	SPATA22	chr17	3349895	-	0.003038446	0.99696153
ENST00000295666	ENST00000268981	IGFBP7	chr4	57906990	-	SPATA22	chr17	3349895	-	0.089349404	0.91065055
ENST00000537922	ENST00000541913	IGFBP7	chr4	57906990	-	SPATA22	chr17	3349895	-	0.003339137	0.9966608
ENST00000537922	ENST00000397168	IGFBP7	chr4	57906990	-	SPATA22	chr17	3349895	-	0.003038446	0.99696153
ENST00000537922	ENST00000572969	IGFBP7	chr4	57906990	-	SPATA22	chr17	3349895	-	0.003038446	0.99696153
ENST00000537922	ENST00000355380	IGFBP7	chr4	57906990	-	SPATA22	chr17	3349895	-	0.003038446	0.99696153
ENST00000537922	ENST00000575375	IGFBP7	chr4	57906990	-	SPATA22	chr17	3349895	-	0.003038446	0.99696153
ENST00000537922	ENST00000573128	IGFBP7	chr4	57906990	-	SPATA22	chr17	3349895	-	0.003038446	0.99696153
ENST00000537922	ENST00000268981	IGFBP7	chr4	57906990	-	SPATA22	chr17	3349895	-	0.089349404	0.91065055

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>38621_38621_1_IGFBP7-SPATA22_IGFBP7_chr4_57906990_ENST00000295666_SPATA22_chr17_3349895_ENST00000268981_length(amino acids)=248AA_BP=202
MPLPPHPAMERPSLRALLLGAAGLLLLLLPLSSSSSSDTCGPCEPASCPPLPPLGCLLGETRDACGCCPMCARGEGEPCGGGGAGRGYCA
PGMECVKSRKRRKGKAGAAAGGPGVSGVCVCKSRYPVCGSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNV

--------------------------------------------------------------

>38621_38621_2_IGFBP7-SPATA22_IGFBP7_chr4_57906990_ENST00000295666_SPATA22_chr17_3349895_ENST00000355380_length(amino acids)=342AA_BP=202
MPLPPHPAMERPSLRALLLGAAGLLLLLLPLSSSSSSDTCGPCEPASCPPLPPLGCLLGETRDACGCCPMCARGEGEPCGGGGAGRGYCA
PGMECVKSRKRRKGKAGAAAGGPGVSGVCVCKSRYPVCGSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNV
TGAQVYLSCEVIGIPTPVLIWNKETSLYQLQFKEKASSLRIISAVIESMKYWREHAQKTVLLFEVLAVLDSAVTPGPYYSKTFLMRDGKN

--------------------------------------------------------------

>38621_38621_3_IGFBP7-SPATA22_IGFBP7_chr4_57906990_ENST00000295666_SPATA22_chr17_3349895_ENST00000397168_length(amino acids)=342AA_BP=202
MPLPPHPAMERPSLRALLLGAAGLLLLLLPLSSSSSSDTCGPCEPASCPPLPPLGCLLGETRDACGCCPMCARGEGEPCGGGGAGRGYCA
PGMECVKSRKRRKGKAGAAAGGPGVSGVCVCKSRYPVCGSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNV
TGAQVYLSCEVIGIPTPVLIWNKETSLYQLQFKEKASSLRIISAVIESMKYWREHAQKTVLLFEVLAVLDSAVTPGPYYSKTFLMRDGKN

--------------------------------------------------------------

>38621_38621_4_IGFBP7-SPATA22_IGFBP7_chr4_57906990_ENST00000295666_SPATA22_chr17_3349895_ENST00000541913_length(amino acids)=342AA_BP=202
MPLPPHPAMERPSLRALLLGAAGLLLLLLPLSSSSSSDTCGPCEPASCPPLPPLGCLLGETRDACGCCPMCARGEGEPCGGGGAGRGYCA
PGMECVKSRKRRKGKAGAAAGGPGVSGVCVCKSRYPVCGSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNV
TGAQVYLSCEVIGIPTPVLIWNKETSLYQLQFKEKASSLRIISAVIESMKYWREHAQKTVLLFEVLAVLDSAVTPGPYYSKTFLMRDGKN

--------------------------------------------------------------

>38621_38621_5_IGFBP7-SPATA22_IGFBP7_chr4_57906990_ENST00000295666_SPATA22_chr17_3349895_ENST00000572969_length(amino acids)=342AA_BP=202
MPLPPHPAMERPSLRALLLGAAGLLLLLLPLSSSSSSDTCGPCEPASCPPLPPLGCLLGETRDACGCCPMCARGEGEPCGGGGAGRGYCA
PGMECVKSRKRRKGKAGAAAGGPGVSGVCVCKSRYPVCGSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNV
TGAQVYLSCEVIGIPTPVLIWNKETSLYQLQFKEKASSLRIISAVIESMKYWREHAQKTVLLFEVLAVLDSAVTPGPYYSKTFLMRDGKN

--------------------------------------------------------------

>38621_38621_6_IGFBP7-SPATA22_IGFBP7_chr4_57906990_ENST00000295666_SPATA22_chr17_3349895_ENST00000573128_length(amino acids)=342AA_BP=202
MPLPPHPAMERPSLRALLLGAAGLLLLLLPLSSSSSSDTCGPCEPASCPPLPPLGCLLGETRDACGCCPMCARGEGEPCGGGGAGRGYCA
PGMECVKSRKRRKGKAGAAAGGPGVSGVCVCKSRYPVCGSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNV
TGAQVYLSCEVIGIPTPVLIWNKETSLYQLQFKEKASSLRIISAVIESMKYWREHAQKTVLLFEVLAVLDSAVTPGPYYSKTFLMRDGKN

--------------------------------------------------------------

>38621_38621_7_IGFBP7-SPATA22_IGFBP7_chr4_57906990_ENST00000295666_SPATA22_chr17_3349895_ENST00000575375_length(amino acids)=342AA_BP=202
MPLPPHPAMERPSLRALLLGAAGLLLLLLPLSSSSSSDTCGPCEPASCPPLPPLGCLLGETRDACGCCPMCARGEGEPCGGGGAGRGYCA
PGMECVKSRKRRKGKAGAAAGGPGVSGVCVCKSRYPVCGSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNV
TGAQVYLSCEVIGIPTPVLIWNKETSLYQLQFKEKASSLRIISAVIESMKYWREHAQKTVLLFEVLAVLDSAVTPGPYYSKTFLMRDGKN

--------------------------------------------------------------

>38621_38621_8_IGFBP7-SPATA22_IGFBP7_chr4_57906990_ENST00000537922_SPATA22_chr17_3349895_ENST00000268981_length(amino acids)=248AA_BP=202
MPLPPHPAMERPSLRALLLGAAGLLLLLLPLSSSSSSDTCGPCEPASCPPLPPLGCLLGETRDACGCCPMCARGEGEPCGGGGAGRGYCA
PGMECVKSRKRRKGKAGAAAGGPGVSGVCVCKSRYPVCGSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNV

--------------------------------------------------------------

>38621_38621_9_IGFBP7-SPATA22_IGFBP7_chr4_57906990_ENST00000537922_SPATA22_chr17_3349895_ENST00000355380_length(amino acids)=342AA_BP=202
MPLPPHPAMERPSLRALLLGAAGLLLLLLPLSSSSSSDTCGPCEPASCPPLPPLGCLLGETRDACGCCPMCARGEGEPCGGGGAGRGYCA
PGMECVKSRKRRKGKAGAAAGGPGVSGVCVCKSRYPVCGSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNV
TGAQVYLSCEVIGIPTPVLIWNKETSLYQLQFKEKASSLRIISAVIESMKYWREHAQKTVLLFEVLAVLDSAVTPGPYYSKTFLMRDGKN

--------------------------------------------------------------

>38621_38621_10_IGFBP7-SPATA22_IGFBP7_chr4_57906990_ENST00000537922_SPATA22_chr17_3349895_ENST00000397168_length(amino acids)=342AA_BP=202
MPLPPHPAMERPSLRALLLGAAGLLLLLLPLSSSSSSDTCGPCEPASCPPLPPLGCLLGETRDACGCCPMCARGEGEPCGGGGAGRGYCA
PGMECVKSRKRRKGKAGAAAGGPGVSGVCVCKSRYPVCGSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNV
TGAQVYLSCEVIGIPTPVLIWNKETSLYQLQFKEKASSLRIISAVIESMKYWREHAQKTVLLFEVLAVLDSAVTPGPYYSKTFLMRDGKN

--------------------------------------------------------------

>38621_38621_11_IGFBP7-SPATA22_IGFBP7_chr4_57906990_ENST00000537922_SPATA22_chr17_3349895_ENST00000541913_length(amino acids)=342AA_BP=202
MPLPPHPAMERPSLRALLLGAAGLLLLLLPLSSSSSSDTCGPCEPASCPPLPPLGCLLGETRDACGCCPMCARGEGEPCGGGGAGRGYCA
PGMECVKSRKRRKGKAGAAAGGPGVSGVCVCKSRYPVCGSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNV
TGAQVYLSCEVIGIPTPVLIWNKETSLYQLQFKEKASSLRIISAVIESMKYWREHAQKTVLLFEVLAVLDSAVTPGPYYSKTFLMRDGKN

--------------------------------------------------------------

>38621_38621_12_IGFBP7-SPATA22_IGFBP7_chr4_57906990_ENST00000537922_SPATA22_chr17_3349895_ENST00000572969_length(amino acids)=342AA_BP=202
MPLPPHPAMERPSLRALLLGAAGLLLLLLPLSSSSSSDTCGPCEPASCPPLPPLGCLLGETRDACGCCPMCARGEGEPCGGGGAGRGYCA
PGMECVKSRKRRKGKAGAAAGGPGVSGVCVCKSRYPVCGSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNV
TGAQVYLSCEVIGIPTPVLIWNKETSLYQLQFKEKASSLRIISAVIESMKYWREHAQKTVLLFEVLAVLDSAVTPGPYYSKTFLMRDGKN

--------------------------------------------------------------

>38621_38621_13_IGFBP7-SPATA22_IGFBP7_chr4_57906990_ENST00000537922_SPATA22_chr17_3349895_ENST00000573128_length(amino acids)=342AA_BP=202
MPLPPHPAMERPSLRALLLGAAGLLLLLLPLSSSSSSDTCGPCEPASCPPLPPLGCLLGETRDACGCCPMCARGEGEPCGGGGAGRGYCA
PGMECVKSRKRRKGKAGAAAGGPGVSGVCVCKSRYPVCGSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNV
TGAQVYLSCEVIGIPTPVLIWNKETSLYQLQFKEKASSLRIISAVIESMKYWREHAQKTVLLFEVLAVLDSAVTPGPYYSKTFLMRDGKN

--------------------------------------------------------------

>38621_38621_14_IGFBP7-SPATA22_IGFBP7_chr4_57906990_ENST00000537922_SPATA22_chr17_3349895_ENST00000575375_length(amino acids)=342AA_BP=202
MPLPPHPAMERPSLRALLLGAAGLLLLLLPLSSSSSSDTCGPCEPASCPPLPPLGCLLGETRDACGCCPMCARGEGEPCGGGGAGRGYCA
PGMECVKSRKRRKGKAGAAAGGPGVSGVCVCKSRYPVCGSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNV
TGAQVYLSCEVIGIPTPVLIWNKETSLYQLQFKEKASSLRIISAVIESMKYWREHAQKTVLLFEVLAVLDSAVTPGPYYSKTFLMRDGKN

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:57906990/chr17:3349895)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
IGFBP7 Q16270	.
FUNCTION: Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. {ECO:0000269\|PubMed:8117260, ECO:0000269\|PubMed:8939990}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

IGFBP7

chr4:57906990

chr17:3349895

ENST00000295666

105_158

195.0

283.0

Domain

Kazal-like

Hgene

IGFBP7

chr4:57906990

chr17:3349895

ENST00000295666

28_106

195.0

283.0

Domain

IGFBP N-terminal

Hgene

IGFBP7

chr4:57906990

chr17:3349895

ENST00000537922

105_158

195.0

280.0

Domain

Kazal-like

Hgene

IGFBP7

chr4:57906990

chr17:3349895

ENST00000537922

28_106

195.0

280.0

Domain

IGFBP N-terminal

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

IGFBP7

chr4:57906990

chr17:3349895

ENST00000295666

160_264

195.0

283.0

Domain

Note=Ig-like C2-type

Hgene

IGFBP7

chr4:57906990

chr17:3349895

ENST00000537922

160_264

195.0

280.0

Domain

Note=Ig-like C2-type

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
IGFBP7
SPATA22

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to IGFBP7-SPATA22

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to IGFBP7-SPATA22

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source