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Fusion Protein:ALDH2-LIN7A |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: ALDH2-LIN7A | FusionPDB ID: 3878 | FusionGDB2.0 ID: 3878 | Hgene | Tgene | Gene symbol | ALDH2 | LIN7A | Gene ID | 217 | 8825 |
| Gene name | aldehyde dehydrogenase 2 family member | lin-7 homolog A, crumbs cell polarity complex component | |
| Synonyms | ALDH-E2|ALDHI|ALDM | LIN-7A|LIN7|MALS-1|MALS1|TIP-33|VELI1 | |
| Cytomap | 12q24.12 | 12q21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | aldehyde dehydrogenase, mitochondrialALDH class 2acetaldehyde dehydrogenase 2aldehyde dehydrogenase 2 family (mitochondrial)epididymis secretory sperm binding proteinliver mitochondrial ALDHnucleus-encoded mitochondrial aldehyde dehydrogenase 2 | protein lin-7 homolog Amammalian lin-seven protein 1tax interaction protein 33vertebrate LIN7 homolog 1 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | P05091 | O14910 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000261733, ENST00000416293, | ENST00000552864, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 26 X 20 X 11=5720 | 12 X 5 X 4=240 |
| # samples | 21 | 7 | |
| ** MAII score | log2(21/5720*10)=-4.76755391399963 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/240*10)=-1.77760757866355 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: ALDH2 [Title/Abstract] AND LIN7A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ALDH2(112204900)-LIN7A(81242101), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | ALDH2-LIN7A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ALDH2-LIN7A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ALDH2-LIN7A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ALDH2-LIN7A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across ALDH2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across LIN7A (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SARC | TCGA-3B-A9HO-01A | ALDH2 | chr12 | 112204900 | - | LIN7A | chr12 | 81242101 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000416293 | ALDH2 | chr12 | 112204900 | - | ENST00000552864 | LIN7A | chr12 | 81242101 | - | 5918 | 210 | 96 | 710 | 204 |
| ENST00000261733 | ALDH2 | chr12 | 112204900 | - | ENST00000552864 | LIN7A | chr12 | 81242101 | - | 5883 | 175 | 61 | 675 | 204 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000416293 | ENST00000552864 | ALDH2 | chr12 | 112204900 | - | LIN7A | chr12 | 81242101 | - | 0.001411533 | 0.9985884 |
| ENST00000261733 | ENST00000552864 | ALDH2 | chr12 | 112204900 | - | LIN7A | chr12 | 81242101 | - | 0.001407128 | 0.9985929 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >3878_3878_1_ALDH2-LIN7A_ALDH2_chr12_112204900_ENST00000261733_LIN7A_chr12_81242101_ENST00000552864_length(amino acids)=204AA_BP=38 MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQVYQYMHETITVNGCPEFRARATAKATVAAFAASEGHSHPRVVELPKTDEGLG FNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLEEMEARFEKLRTARRR -------------------------------------------------------------- >3878_3878_2_ALDH2-LIN7A_ALDH2_chr12_112204900_ENST00000416293_LIN7A_chr12_81242101_ENST00000552864_length(amino acids)=204AA_BP=38 MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQVYQYMHETITVNGCPEFRARATAKATVAAFAASEGHSHPRVVELPKTDEGLG FNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLEEMEARFEKLRTARRR -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:112204900/chr12:81242101) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ALDH2 | LIN7A |
| FUNCTION: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000250|UniProtKB:Q8JZS0, ECO:0000269|PubMed:12967566}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | LIN7A | chr12:112204900 | chr12:81242101 | ENST00000552864 | 1 | 6 | 210_213 | 67.0 | 1908.0 | Compositional bias | Note=Poly-Gln | |
| Tgene | LIN7A | chr12:112204900 | chr12:81242101 | ENST00000552864 | 1 | 6 | 217_229 | 67.0 | 1908.0 | Compositional bias | Note=Poly-Gln | |
| Tgene | LIN7A | chr12:112204900 | chr12:81242101 | ENST00000552864 | 1 | 6 | 108_190 | 67.0 | 1908.0 | Domain | PDZ |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ALDH2 | chr12:112204900 | chr12:81242101 | ENST00000261733 | - | 1 | 13 | 262_267 | 38.0 | 518.0 | Nucleotide binding | NAD |
| Hgene | ALDH2 | chr12:112204900 | chr12:81242101 | ENST00000416293 | - | 1 | 12 | 262_267 | 38.0 | 471.0 | Nucleotide binding | NAD |
| Tgene | LIN7A | chr12:112204900 | chr12:81242101 | ENST00000552864 | 1 | 6 | 25_80 | 67.0 | 1908.0 | Domain | L27 | |
| Tgene | LIN7A | chr12:112204900 | chr12:81242101 | ENST00000552864 | 1 | 6 | 14_28 | 67.0 | 1908.0 | Motif | Note=Kinase interacting site |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| ALDH2 |  |
| LIN7A |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to ALDH2-LIN7A |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to ALDH2-LIN7A |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ALDH2 | C0001973 | Alcoholic Intoxication, Chronic | 7 | CTD_human;PSYGENET |
| Hgene | ALDH2 | C0085762 | Alcohol abuse | 7 | CTD_human;PSYGENET |
| Hgene | ALDH2 | C0001969 | Alcoholic Intoxication | 5 | PSYGENET |
| Hgene | ALDH2 | C0393756 | Hangover from alcohol | 4 | PSYGENET |
| Hgene | ALDH2 | C0236664 | Alcohol-Related Disorders | 3 | PSYGENET |
| Hgene | ALDH2 | C0001956 | Alcohol Use Disorder | 2 | CTD_human |
| Hgene | ALDH2 | C0004096 | Asthma | 2 | CTD_human |
| Hgene | ALDH2 | C0005586 | Bipolar Disorder | 2 | PSYGENET |
| Hgene | ALDH2 | C0279626 | Squamous cell carcinoma of esophagus | 2 | CTD_human |
| Hgene | ALDH2 | C0009402 | Colorectal Carcinoma | 1 | CTD_human |
| Hgene | ALDH2 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Hgene | ALDH2 | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
| Hgene | ALDH2 | C0016382 | Flushing | 1 | CTD_human |
| Hgene | ALDH2 | C0016689 | Freckles | 1 | CTD_human |
| Hgene | ALDH2 | C0021364 | Male infertility | 1 | CTD_human |
| Hgene | ALDH2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | ALDH2 | C0025209 | Melanosis | 1 | CTD_human |
| Hgene | ALDH2 | C0025218 | Chloasma | 1 | CTD_human |
| Hgene | ALDH2 | C0028796 | Dermatitis, Occupational | 1 | CTD_human |
| Hgene | ALDH2 | C0032927 | Precancerous Conditions | 1 | CTD_human |
| Hgene | ALDH2 | C0042373 | Vascular Diseases | 1 | CTD_human |
| Hgene | ALDH2 | C0086457 | Industrial Dermatosis | 1 | CTD_human |
| Hgene | ALDH2 | C0236970 | Alcohol-Induced Disorders | 1 | CTD_human |
| Hgene | ALDH2 | C0242973 | Ventricular Dysfunction | 1 | CTD_human |
| Hgene | ALDH2 | C0282313 | Condition, Preneoplastic | 1 | CTD_human |
| Hgene | ALDH2 | C0342257 | Complications of Diabetes Mellitus | 1 | CTD_human |
| Hgene | ALDH2 | C0349464 | Wernicke-Korsakoff Syndrome | 1 | PSYGENET |
| Hgene | ALDH2 | C0400966 | Non-alcoholic Fatty Liver Disease | 1 | CTD_human |
| Hgene | ALDH2 | C0520459 | Necrotizing Enterocolitis | 1 | CTD_human |
| Hgene | ALDH2 | C0546837 | Malignant neoplasm of esophagus | 1 | CTD_human |
| Hgene | ALDH2 | C0848676 | Subfertility, Male | 1 | CTD_human |
| Hgene | ALDH2 | C0917731 | Male sterility | 1 | CTD_human |
| Hgene | ALDH2 | C2674838 | ALCOHOL SENSITIVITY, ACUTE | 1 | CTD_human |
| Hgene | ALDH2 | C3241937 | Nonalcoholic Steatohepatitis | 1 | CTD_human |
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