UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:IGHMBP2-GPR137

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: IGHMBP2-GPR137
FusionPDB ID: 38886
FusionGDB2.0 ID: 38886
HgeneTgene
Gene symbol

IGHMBP2

GPR137

Gene ID

3508

56834

Gene nameimmunoglobulin mu DNA binding protein 2G protein-coupled receptor 137
SynonymsCATF1|CMT2S|HCSA|HMN6|SMARD1|SMUBP2|ZFAND7C11orf4|GPR137A|TM7SF1L1
Cytomap

11q13.3

11q13.1

Type of geneprotein-codingprotein-coding
DescriptionDNA-binding protein SMUBP-2ATP-dependent helicase IGHMBP2GF-1cardiac transcription factor 1glial factor 1immunoglobulin mu binding protein 2zinc finger, AN1-type domain 7integral membrane protein GPR137transmembrane 7 superfamily member 1-like 1 protein
Modification date2020032820200313
UniProtAcc

P38935

Q8N3F9

Ensembl transtripts involved in fusion geneENST idsENST00000539224, ENST00000255078, 
ENST00000541229, 		ENST00000313074, 
ENST00000377702, ENST00000411458, 
ENST00000438980, ENST00000539851, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 6 X 5=2107 X 8 X 6=336
# samples 77
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/336*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: IGHMBP2 [Title/Abstract] AND GPR137 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)IGHMBP2(68679071)-GPR137(64055812), # samples:3
Anticipated loss of major functional domain due to fusion event.IGHMBP2-GPR137 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
IGHMBP2-GPR137 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across IGHMBP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GPR137 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-SL-A6J9-01AIGHMBP2chr11

68679071

+GPR137chr11

64054437

+
ChimerDB4UCECTCGA-SL-A6J9-01AIGHMBP2chr11

68679071

-GPR137chr11

64055812

+
ChimerDB4UCECTCGA-SL-A6J9-01AIGHMBP2chr11

68679071

+GPR137chr11

64055812

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000255078IGHMBP2chr1168679071+ENST00000411458GPR137chr1164055812+13328221111292393
ENST00000255078IGHMBP2chr1168679071+ENST00000539851GPR137chr1164055812+14158221111001296
ENST00000255078IGHMBP2chr1168679071+ENST00000377702GPR137chr1164055812+15288221111229372
ENST00000255078IGHMBP2chr1168679071+ENST00000438980GPR137chr1164055812+15288221111229372
ENST00000255078IGHMBP2chr1168679071+ENST00000313074GPR137chr1164055812+14198221111292393
ENST00000255078IGHMBP2chr1168679071+ENST00000411458GPR137chr1164054437+17588221111718535
ENST00000255078IGHMBP2chr1168679071+ENST00000539851GPR137chr1164054437+18418221111427438
ENST00000255078IGHMBP2chr1168679071+ENST00000377702GPR137chr1164054437+18048221111505464
ENST00000255078IGHMBP2chr1168679071+ENST00000438980GPR137chr1164054437+19548221111655514
ENST00000255078IGHMBP2chr1168679071+ENST00000313074GPR137chr1164054437+18458221111718535

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000255078ENST00000411458IGHMBP2chr1168679071+GPR137chr1164055812+0.0559178180.94408214
ENST00000255078ENST00000539851IGHMBP2chr1168679071+GPR137chr1164055812+0.0126316980.9873683
ENST00000255078ENST00000377702IGHMBP2chr1168679071+GPR137chr1164055812+0.024954810.97504514
ENST00000255078ENST00000438980IGHMBP2chr1168679071+GPR137chr1164055812+0.024954810.97504514
ENST00000255078ENST00000313074IGHMBP2chr1168679071+GPR137chr1164055812+0.0576578450.9423421
ENST00000255078ENST00000411458IGHMBP2chr1168679071+GPR137chr1164054437+0.012258110.9877418
ENST00000255078ENST00000539851IGHMBP2chr1168679071+GPR137chr1164054437+0.0067582080.9932417
ENST00000255078ENST00000377702IGHMBP2chr1168679071+GPR137chr1164054437+0.0184510370.98154896
ENST00000255078ENST00000438980IGHMBP2chr1168679071+GPR137chr1164054437+0.0094466090.9905533
ENST00000255078ENST00000313074IGHMBP2chr1168679071+GPR137chr1164054437+0.0122892790.98771065

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>38886_38886_1_IGHMBP2-GPR137_IGHMBP2_chr11_68679071_ENST00000255078_GPR137_chr11_64054437_ENST00000313074_length(amino acids)=535AA_BP=237
MASAAVESFVTKQLDLLELERDAEVEERRSWQENISLKELQSRGVCLLKLQVSSQRTGLYGRLLVTFEPRRYGSAAALPSNSFTSGDIVG
LYDAANEGSQLATGILTRVTQKSVTVAFDESHDFQLSLDRENSYRLLKLANDVTYRRLKKALIALKKYHSGPASSLIEVLFGRSAPSPAS
EIHPLTFFNTCLDTSQKEAVLFALSQKELAIIHGPPGTGKTTTVVEIILQAVKQGLKVVFKAKVKRRPEMSRGLLAVRGAFVGASLLFLL
VNVLCAVLSHRRRAQPWALLLVRVLVSDSLFVICALSLAACLCLVARRAPSTSIYLEAKGTSVCQAAAMGGAMVLLYASRACYNLTALAL
APQSRLDTFDYDWYNVSDQADLVNDLGNKGYLVFGLILFVWELLPTTLLVGFFRVHRPPQDLSTSHILNGQVFASRSYFFDRAGHCEDEG

--------------------------------------------------------------

>38886_38886_2_IGHMBP2-GPR137_IGHMBP2_chr11_68679071_ENST00000255078_GPR137_chr11_64054437_ENST00000377702_length(amino acids)=464AA_BP=237
MASAAVESFVTKQLDLLELERDAEVEERRSWQENISLKELQSRGVCLLKLQVSSQRTGLYGRLLVTFEPRRYGSAAALPSNSFTSGDIVG
LYDAANEGSQLATGILTRVTQKSVTVAFDESHDFQLSLDRENSYRLLKLANDVTYRRLKKALIALKKYHSGPASSLIEVLFGRSAPSPAS
EIHPLTFFNTCLDTSQKEAVLFALSQKELAIIHGPPGTGKTTTVVEIILQAVKQGLKVVFKAKVKRRPEMSRGLLAVRGAFVGASLLFLL
VNVLCAVLSHRRRAQPWALLLVRVLVSDSLFVICALSLAACLCLVARRAPSTSIYLEAKADLVNDLGNKGYLVFGLILFVWELLPTTLLV
GFFRVHRPPQDLSTSHILNGQVFASRSYFFDRAGHCEDEGCSWEHSRGESTSMSGSLGSGSWYGAIGREPGWYGGSQTKTTPLLFSQVPG

--------------------------------------------------------------

>38886_38886_3_IGHMBP2-GPR137_IGHMBP2_chr11_68679071_ENST00000255078_GPR137_chr11_64054437_ENST00000411458_length(amino acids)=535AA_BP=237
MASAAVESFVTKQLDLLELERDAEVEERRSWQENISLKELQSRGVCLLKLQVSSQRTGLYGRLLVTFEPRRYGSAAALPSNSFTSGDIVG
LYDAANEGSQLATGILTRVTQKSVTVAFDESHDFQLSLDRENSYRLLKLANDVTYRRLKKALIALKKYHSGPASSLIEVLFGRSAPSPAS
EIHPLTFFNTCLDTSQKEAVLFALSQKELAIIHGPPGTGKTTTVVEIILQAVKQGLKVVFKAKVKRRPEMSRGLLAVRGAFVGASLLFLL
VNVLCAVLSHRRRAQPWALLLVRVLVSDSLFVICALSLAACLCLVARRAPSTSIYLEAKGTSVCQAAAMGGAMVLLYASRACYNLTALAL
APQSRLDTFDYDWYNVSDQADLVNDLGNKGYLVFGLILFVWELLPTTLLVGFFRVHRPPQDLSTSHILNGQVFASRSYFFDRAGHCEDEG

--------------------------------------------------------------

>38886_38886_4_IGHMBP2-GPR137_IGHMBP2_chr11_68679071_ENST00000255078_GPR137_chr11_64054437_ENST00000438980_length(amino acids)=514AA_BP=237
MASAAVESFVTKQLDLLELERDAEVEERRSWQENISLKELQSRGVCLLKLQVSSQRTGLYGRLLVTFEPRRYGSAAALPSNSFTSGDIVG
LYDAANEGSQLATGILTRVTQKSVTVAFDESHDFQLSLDRENSYRLLKLANDVTYRRLKKALIALKKYHSGPASSLIEVLFGRSAPSPAS
EIHPLTFFNTCLDTSQKEAVLFALSQKELAIIHGPPGTGKTTTVVEIILQAVKQGLKVVFKAKVKRRPEMSRGLLAVRGAFVGASLLFLL
VNVLCAVLSHRRRAQPWALLLVRVLVSDSLFVICALSLAACLCLVARRAPSTSIYLEAKGTSVCQAAAMGGAMVLLYASRACYNLTALAL
APQSRLDTFDYDWYNVSDQADLVNDLGNKGYLVFGLILFVWELLPTTLLVGFFRVHRPPQDLSTSHILNGQVFASRSYFFDRAGHCEDEG

--------------------------------------------------------------

>38886_38886_5_IGHMBP2-GPR137_IGHMBP2_chr11_68679071_ENST00000255078_GPR137_chr11_64054437_ENST00000539851_length(amino acids)=438AA_BP=237
MASAAVESFVTKQLDLLELERDAEVEERRSWQENISLKELQSRGVCLLKLQVSSQRTGLYGRLLVTFEPRRYGSAAALPSNSFTSGDIVG
LYDAANEGSQLATGILTRVTQKSVTVAFDESHDFQLSLDRENSYRLLKLANDVTYRRLKKALIALKKYHSGPASSLIEVLFGRSAPSPAS
EIHPLTFFNTCLDTSQKEAVLFALSQKELAIIHGPPGTGKTTTVVEIILQAVKQGLKVVFKAKVKRRPEMSRGLLAVRGAFVGASLLFLL
VNVLCAVLSHRRRAQPWALLLVRVLVSDSLFVICALSLAACLCLVARRAPSTSIYLEAKGTSVCQAAAMGGAMVLLYASRACYNLTALAL

--------------------------------------------------------------

>38886_38886_6_IGHMBP2-GPR137_IGHMBP2_chr11_68679071_ENST00000255078_GPR137_chr11_64055812_ENST00000313074_length(amino acids)=393AA_BP=237
MASAAVESFVTKQLDLLELERDAEVEERRSWQENISLKELQSRGVCLLKLQVSSQRTGLYGRLLVTFEPRRYGSAAALPSNSFTSGDIVG
LYDAANEGSQLATGILTRVTQKSVTVAFDESHDFQLSLDRENSYRLLKLANDVTYRRLKKALIALKKYHSGPASSLIEVLFGRSAPSPAS
EIHPLTFFNTCLDTSQKEAVLFALSQKELAIIHGPPGTGKTTTVVEIILQAVKQGLKADLVNDLGNKGYLVFGLILFVWELLPTTLLVGF
FRVHRPPQDLSTSHILNGQVFASRSYFFDRAGHCEDEGCSWEHSRGESTRCQDQAATTTVSTPPHRRDPPPSPTEYPGPSPPHPRPLCQV

--------------------------------------------------------------

>38886_38886_7_IGHMBP2-GPR137_IGHMBP2_chr11_68679071_ENST00000255078_GPR137_chr11_64055812_ENST00000377702_length(amino acids)=372AA_BP=237
MASAAVESFVTKQLDLLELERDAEVEERRSWQENISLKELQSRGVCLLKLQVSSQRTGLYGRLLVTFEPRRYGSAAALPSNSFTSGDIVG
LYDAANEGSQLATGILTRVTQKSVTVAFDESHDFQLSLDRENSYRLLKLANDVTYRRLKKALIALKKYHSGPASSLIEVLFGRSAPSPAS
EIHPLTFFNTCLDTSQKEAVLFALSQKELAIIHGPPGTGKTTTVVEIILQAVKQGLKADLVNDLGNKGYLVFGLILFVWELLPTTLLVGF
FRVHRPPQDLSTSHILNGQVFASRSYFFDRAGHCEDEGCSWEHSRGESTSMSGSLGSGSWYGAIGREPGWYGGSQTKTTPLLFSQVPGPG

--------------------------------------------------------------

>38886_38886_8_IGHMBP2-GPR137_IGHMBP2_chr11_68679071_ENST00000255078_GPR137_chr11_64055812_ENST00000411458_length(amino acids)=393AA_BP=237
MASAAVESFVTKQLDLLELERDAEVEERRSWQENISLKELQSRGVCLLKLQVSSQRTGLYGRLLVTFEPRRYGSAAALPSNSFTSGDIVG
LYDAANEGSQLATGILTRVTQKSVTVAFDESHDFQLSLDRENSYRLLKLANDVTYRRLKKALIALKKYHSGPASSLIEVLFGRSAPSPAS
EIHPLTFFNTCLDTSQKEAVLFALSQKELAIIHGPPGTGKTTTVVEIILQAVKQGLKADLVNDLGNKGYLVFGLILFVWELLPTTLLVGF
FRVHRPPQDLSTSHILNGQVFASRSYFFDRAGHCEDEGCSWEHSRGESTRCQDQAATTTVSTPPHRRDPPPSPTEYPGPSPPHPRPLCQV

--------------------------------------------------------------

>38886_38886_9_IGHMBP2-GPR137_IGHMBP2_chr11_68679071_ENST00000255078_GPR137_chr11_64055812_ENST00000438980_length(amino acids)=372AA_BP=237
MASAAVESFVTKQLDLLELERDAEVEERRSWQENISLKELQSRGVCLLKLQVSSQRTGLYGRLLVTFEPRRYGSAAALPSNSFTSGDIVG
LYDAANEGSQLATGILTRVTQKSVTVAFDESHDFQLSLDRENSYRLLKLANDVTYRRLKKALIALKKYHSGPASSLIEVLFGRSAPSPAS
EIHPLTFFNTCLDTSQKEAVLFALSQKELAIIHGPPGTGKTTTVVEIILQAVKQGLKADLVNDLGNKGYLVFGLILFVWELLPTTLLVGF
FRVHRPPQDLSTSHILNGQVFASRSYFFDRAGHCEDEGCSWEHSRGESTSMSGSLGSGSWYGAIGREPGWYGGSQTKTTPLLFSQVPGPG

--------------------------------------------------------------

>38886_38886_10_IGHMBP2-GPR137_IGHMBP2_chr11_68679071_ENST00000255078_GPR137_chr11_64055812_ENST00000539851_length(amino acids)=296AA_BP=237
MASAAVESFVTKQLDLLELERDAEVEERRSWQENISLKELQSRGVCLLKLQVSSQRTGLYGRLLVTFEPRRYGSAAALPSNSFTSGDIVG
LYDAANEGSQLATGILTRVTQKSVTVAFDESHDFQLSLDRENSYRLLKLANDVTYRRLKKALIALKKYHSGPASSLIEVLFGRSAPSPAS
EIHPLTFFNTCLDTSQKEAVLFALSQKELAIIHGPPGTGKTTTVVEIILQAVKQGLKADLVNDLGNKGYLVFGLILFVWELLPTTLLVGF

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:68679071/chr11:64055812)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IGHMBP2

P38935

GPR137

Q8N3F9

FUNCTION: 5' to 3' helicase that unwinds RNA and DNA duplices in an ATP-dependent reaction. Acts as a transcription regulator. Required for the transcriptional activation of the flounder liver-type antifreeze protein gene. Exhibits strong binding specificity to the enhancer element B of the flounder antifreeze protein gene intron. Binds to the insulin II gene RIPE3B enhancer region. May be involved in translation (By similarity). DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch region. Preferentially binds to the 5'-GGGCT-3' motif. Interacts with tRNA-Tyr. Stimulates the transcription of the human neurotropic virus JCV. {ECO:0000250, ECO:0000269|PubMed:19158098, ECO:0000269|PubMed:19299493}.FUNCTION: Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. {ECO:0000269|PubMed:31036939}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIGHMBP2chr11:68679071chr11:64054437ENST00000255078+515214_221237.0994.0Nucleotide bindingATP
HgeneIGHMBP2chr11:68679071chr11:64055812ENST00000255078+515214_221237.0994.0Nucleotide bindingATP
TgeneGPR137chr11:68679071chr11:64054437ENST0000031307407162_175119.0418.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64054437ENST0000031307407197_218119.0418.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64054437ENST0000031307407242_274119.0418.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64054437ENST0000031307407296_417119.0418.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64054437ENST0000037770217162_175119.0347.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64054437ENST0000037770217197_218119.0347.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64054437ENST0000037770217242_274119.0347.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64054437ENST0000037770217296_417119.0347.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64054437ENST0000041145829197_218177.0476.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64054437ENST0000041145829242_274177.0476.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64054437ENST0000041145829296_417177.0476.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64054437ENST0000043898007162_175119.0397.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64054437ENST0000043898007197_218119.0397.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64054437ENST0000043898007242_274119.0397.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64054437ENST0000043898007296_417119.0397.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64054437ENST0000053985117162_175119.0321.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64054437ENST0000053985117197_218119.0321.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64054437ENST0000053985117242_274119.0321.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64054437ENST0000053985117296_417119.0321.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64055812ENST0000031307437296_417261.0418.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64055812ENST0000037770237242_274211.0347.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64055812ENST0000037770237296_417211.0347.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64055812ENST0000043898037296_417261.0397.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64055812ENST0000053985147296_417261.0321.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64054437ENST0000031307407141_161119.0418.0TransmembraneHelical%3B Name%3D4
TgeneGPR137chr11:68679071chr11:64054437ENST0000031307407176_196119.0418.0TransmembraneHelical%3B Name%3D5
TgeneGPR137chr11:68679071chr11:64054437ENST0000031307407219_241119.0418.0TransmembraneHelical%3B Name%3D6
TgeneGPR137chr11:68679071chr11:64054437ENST0000031307407275_295119.0418.0TransmembraneHelical%3B Name%3D7
TgeneGPR137chr11:68679071chr11:64054437ENST0000037770217141_161119.0347.0TransmembraneHelical%3B Name%3D4
TgeneGPR137chr11:68679071chr11:64054437ENST0000037770217176_196119.0347.0TransmembraneHelical%3B Name%3D5
TgeneGPR137chr11:68679071chr11:64054437ENST0000037770217219_241119.0347.0TransmembraneHelical%3B Name%3D6
TgeneGPR137chr11:68679071chr11:64054437ENST0000037770217275_295119.0347.0TransmembraneHelical%3B Name%3D7
TgeneGPR137chr11:68679071chr11:64054437ENST0000041145829176_196177.0476.0TransmembraneHelical%3B Name%3D5
TgeneGPR137chr11:68679071chr11:64054437ENST0000041145829219_241177.0476.0TransmembraneHelical%3B Name%3D6
TgeneGPR137chr11:68679071chr11:64054437ENST0000041145829275_295177.0476.0TransmembraneHelical%3B Name%3D7
TgeneGPR137chr11:68679071chr11:64054437ENST0000043898007141_161119.0397.0TransmembraneHelical%3B Name%3D4
TgeneGPR137chr11:68679071chr11:64054437ENST0000043898007176_196119.0397.0TransmembraneHelical%3B Name%3D5
TgeneGPR137chr11:68679071chr11:64054437ENST0000043898007219_241119.0397.0TransmembraneHelical%3B Name%3D6
TgeneGPR137chr11:68679071chr11:64054437ENST0000043898007275_295119.0397.0TransmembraneHelical%3B Name%3D7
TgeneGPR137chr11:68679071chr11:64054437ENST0000053985117141_161119.0321.0TransmembraneHelical%3B Name%3D4
TgeneGPR137chr11:68679071chr11:64054437ENST0000053985117176_196119.0321.0TransmembraneHelical%3B Name%3D5
TgeneGPR137chr11:68679071chr11:64054437ENST0000053985117219_241119.0321.0TransmembraneHelical%3B Name%3D6
TgeneGPR137chr11:68679071chr11:64054437ENST0000053985117275_295119.0321.0TransmembraneHelical%3B Name%3D7
TgeneGPR137chr11:68679071chr11:64055812ENST0000031307437275_295261.0418.0TransmembraneHelical%3B Name%3D7
TgeneGPR137chr11:68679071chr11:64055812ENST0000037770237219_241211.0347.0TransmembraneHelical%3B Name%3D6
TgeneGPR137chr11:68679071chr11:64055812ENST0000037770237275_295211.0347.0TransmembraneHelical%3B Name%3D7
TgeneGPR137chr11:68679071chr11:64055812ENST0000043898037275_295261.0397.0TransmembraneHelical%3B Name%3D7
TgeneGPR137chr11:68679071chr11:64055812ENST0000053985147275_295261.0321.0TransmembraneHelical%3B Name%3D7

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIGHMBP2chr11:68679071chr11:64054437ENST00000255078+515251_426237.0994.0Compositional biasNote=Leu-rich
HgeneIGHMBP2chr11:68679071chr11:64054437ENST00000255078+515795_859237.0994.0Compositional biasNote=Gln/Pro-rich
HgeneIGHMBP2chr11:68679071chr11:64054437ENST00000255078+515864_870237.0994.0Compositional biasNote=Poly-Lys
HgeneIGHMBP2chr11:68679071chr11:64055812ENST00000255078+515251_426237.0994.0Compositional biasNote=Leu-rich
HgeneIGHMBP2chr11:68679071chr11:64055812ENST00000255078+515795_859237.0994.0Compositional biasNote=Gln/Pro-rich
HgeneIGHMBP2chr11:68679071chr11:64055812ENST00000255078+515864_870237.0994.0Compositional biasNote=Poly-Lys
HgeneIGHMBP2chr11:68679071chr11:64054437ENST00000255078+515723_786237.0994.0DomainR3H
HgeneIGHMBP2chr11:68679071chr11:64055812ENST00000255078+515723_786237.0994.0DomainR3H
HgeneIGHMBP2chr11:68679071chr11:64054437ENST00000255078+515864_868237.0994.0MotifNuclear localization signal
HgeneIGHMBP2chr11:68679071chr11:64055812ENST00000255078+515864_868237.0994.0MotifNuclear localization signal
HgeneIGHMBP2chr11:68679071chr11:64054437ENST00000255078+515638_785237.0994.0RegionSS DNA-binding
HgeneIGHMBP2chr11:68679071chr11:64055812ENST00000255078+515638_785237.0994.0RegionSS DNA-binding
HgeneIGHMBP2chr11:68679071chr11:64054437ENST00000255078+515894_940237.0994.0Zinc fingerAN1-type
HgeneIGHMBP2chr11:68679071chr11:64055812ENST00000255078+515894_940237.0994.0Zinc fingerAN1-type
TgeneGPR137chr11:68679071chr11:64054437ENST0000031307407111_140119.0418.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64054437ENST00000313074071_31119.0418.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64054437ENST000003130740753_60119.0418.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64054437ENST000003130740782_89119.0418.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64054437ENST0000037770217111_140119.0347.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64054437ENST00000377702171_31119.0347.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64054437ENST000003777021753_60119.0347.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64054437ENST000003777021782_89119.0347.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64054437ENST0000041145829111_140177.0476.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64054437ENST0000041145829162_175177.0476.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64054437ENST00000411458291_31177.0476.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64054437ENST000004114582953_60177.0476.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64054437ENST000004114582982_89177.0476.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64054437ENST0000043898007111_140119.0397.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64054437ENST00000438980071_31119.0397.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64054437ENST000004389800753_60119.0397.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64054437ENST000004389800782_89119.0397.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64054437ENST0000053985117111_140119.0321.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64054437ENST00000539851171_31119.0321.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64054437ENST000005398511753_60119.0321.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64054437ENST000005398511782_89119.0321.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64055812ENST0000031307437111_140261.0418.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64055812ENST0000031307437162_175261.0418.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64055812ENST0000031307437197_218261.0418.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64055812ENST00000313074371_31261.0418.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64055812ENST0000031307437242_274261.0418.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64055812ENST000003130743753_60261.0418.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64055812ENST000003130743782_89261.0418.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64055812ENST0000037770237111_140211.0347.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64055812ENST0000037770237162_175211.0347.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64055812ENST0000037770237197_218211.0347.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64055812ENST00000377702371_31211.0347.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64055812ENST000003777023753_60211.0347.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64055812ENST000003777023782_89211.0347.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64055812ENST0000041145859111_140319.0476.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64055812ENST0000041145859162_175319.0476.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64055812ENST0000041145859197_218319.0476.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64055812ENST00000411458591_31319.0476.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64055812ENST0000041145859242_274319.0476.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64055812ENST0000041145859296_417319.0476.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64055812ENST000004114585953_60319.0476.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64055812ENST000004114585982_89319.0476.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64055812ENST0000043898037111_140261.0397.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64055812ENST0000043898037162_175261.0397.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64055812ENST0000043898037197_218261.0397.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64055812ENST00000438980371_31261.0397.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64055812ENST0000043898037242_274261.0397.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64055812ENST000004389803753_60261.0397.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64055812ENST000004389803782_89261.0397.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64055812ENST0000053985147111_140261.0321.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64055812ENST0000053985147162_175261.0321.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64055812ENST0000053985147197_218261.0321.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64055812ENST00000539851471_31261.0321.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64055812ENST0000053985147242_274261.0321.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64055812ENST000005398514753_60261.0321.0Topological domainCytoplasmic
TgeneGPR137chr11:68679071chr11:64055812ENST000005398514782_89261.0321.0Topological domainLumenal
TgeneGPR137chr11:68679071chr11:64054437ENST000003130740732_52119.0418.0TransmembraneHelical%3B Name%3D1
TgeneGPR137chr11:68679071chr11:64054437ENST000003130740761_81119.0418.0TransmembraneHelical%3B Name%3D2
TgeneGPR137chr11:68679071chr11:64054437ENST000003130740790_110119.0418.0TransmembraneHelical%3B Name%3D3
TgeneGPR137chr11:68679071chr11:64054437ENST000003777021732_52119.0347.0TransmembraneHelical%3B Name%3D1
TgeneGPR137chr11:68679071chr11:64054437ENST000003777021761_81119.0347.0TransmembraneHelical%3B Name%3D2
TgeneGPR137chr11:68679071chr11:64054437ENST000003777021790_110119.0347.0TransmembraneHelical%3B Name%3D3
TgeneGPR137chr11:68679071chr11:64054437ENST0000041145829141_161177.0476.0TransmembraneHelical%3B Name%3D4
TgeneGPR137chr11:68679071chr11:64054437ENST000004114582932_52177.0476.0TransmembraneHelical%3B Name%3D1
TgeneGPR137chr11:68679071chr11:64054437ENST000004114582961_81177.0476.0TransmembraneHelical%3B Name%3D2
TgeneGPR137chr11:68679071chr11:64054437ENST000004114582990_110177.0476.0TransmembraneHelical%3B Name%3D3
TgeneGPR137chr11:68679071chr11:64054437ENST000004389800732_52119.0397.0TransmembraneHelical%3B Name%3D1
TgeneGPR137chr11:68679071chr11:64054437ENST000004389800761_81119.0397.0TransmembraneHelical%3B Name%3D2
TgeneGPR137chr11:68679071chr11:64054437ENST000004389800790_110119.0397.0TransmembraneHelical%3B Name%3D3
TgeneGPR137chr11:68679071chr11:64054437ENST000005398511732_52119.0321.0TransmembraneHelical%3B Name%3D1
TgeneGPR137chr11:68679071chr11:64054437ENST000005398511761_81119.0321.0TransmembraneHelical%3B Name%3D2
TgeneGPR137chr11:68679071chr11:64054437ENST000005398511790_110119.0321.0TransmembraneHelical%3B Name%3D3
TgeneGPR137chr11:68679071chr11:64055812ENST0000031307437141_161261.0418.0TransmembraneHelical%3B Name%3D4
TgeneGPR137chr11:68679071chr11:64055812ENST0000031307437176_196261.0418.0TransmembraneHelical%3B Name%3D5
TgeneGPR137chr11:68679071chr11:64055812ENST0000031307437219_241261.0418.0TransmembraneHelical%3B Name%3D6
TgeneGPR137chr11:68679071chr11:64055812ENST000003130743732_52261.0418.0TransmembraneHelical%3B Name%3D1
TgeneGPR137chr11:68679071chr11:64055812ENST000003130743761_81261.0418.0TransmembraneHelical%3B Name%3D2
TgeneGPR137chr11:68679071chr11:64055812ENST000003130743790_110261.0418.0TransmembraneHelical%3B Name%3D3
TgeneGPR137chr11:68679071chr11:64055812ENST0000037770237141_161211.0347.0TransmembraneHelical%3B Name%3D4
TgeneGPR137chr11:68679071chr11:64055812ENST0000037770237176_196211.0347.0TransmembraneHelical%3B Name%3D5
TgeneGPR137chr11:68679071chr11:64055812ENST000003777023732_52211.0347.0TransmembraneHelical%3B Name%3D1
TgeneGPR137chr11:68679071chr11:64055812ENST000003777023761_81211.0347.0TransmembraneHelical%3B Name%3D2
TgeneGPR137chr11:68679071chr11:64055812ENST000003777023790_110211.0347.0TransmembraneHelical%3B Name%3D3
TgeneGPR137chr11:68679071chr11:64055812ENST0000041145859141_161319.0476.0TransmembraneHelical%3B Name%3D4
TgeneGPR137chr11:68679071chr11:64055812ENST0000041145859176_196319.0476.0TransmembraneHelical%3B Name%3D5
TgeneGPR137chr11:68679071chr11:64055812ENST0000041145859219_241319.0476.0TransmembraneHelical%3B Name%3D6
TgeneGPR137chr11:68679071chr11:64055812ENST0000041145859275_295319.0476.0TransmembraneHelical%3B Name%3D7
TgeneGPR137chr11:68679071chr11:64055812ENST000004114585932_52319.0476.0TransmembraneHelical%3B Name%3D1
TgeneGPR137chr11:68679071chr11:64055812ENST000004114585961_81319.0476.0TransmembraneHelical%3B Name%3D2
TgeneGPR137chr11:68679071chr11:64055812ENST000004114585990_110319.0476.0TransmembraneHelical%3B Name%3D3
TgeneGPR137chr11:68679071chr11:64055812ENST0000043898037141_161261.0397.0TransmembraneHelical%3B Name%3D4
TgeneGPR137chr11:68679071chr11:64055812ENST0000043898037176_196261.0397.0TransmembraneHelical%3B Name%3D5
TgeneGPR137chr11:68679071chr11:64055812ENST0000043898037219_241261.0397.0TransmembraneHelical%3B Name%3D6
TgeneGPR137chr11:68679071chr11:64055812ENST000004389803732_52261.0397.0TransmembraneHelical%3B Name%3D1
TgeneGPR137chr11:68679071chr11:64055812ENST000004389803761_81261.0397.0TransmembraneHelical%3B Name%3D2
TgeneGPR137chr11:68679071chr11:64055812ENST000004389803790_110261.0397.0TransmembraneHelical%3B Name%3D3
TgeneGPR137chr11:68679071chr11:64055812ENST0000053985147141_161261.0321.0TransmembraneHelical%3B Name%3D4
TgeneGPR137chr11:68679071chr11:64055812ENST0000053985147176_196261.0321.0TransmembraneHelical%3B Name%3D5
TgeneGPR137chr11:68679071chr11:64055812ENST0000053985147219_241261.0321.0TransmembraneHelical%3B Name%3D6
TgeneGPR137chr11:68679071chr11:64055812ENST000005398514732_52261.0321.0TransmembraneHelical%3B Name%3D1
TgeneGPR137chr11:68679071chr11:64055812ENST000005398514761_81261.0321.0TransmembraneHelical%3B Name%3D2
TgeneGPR137chr11:68679071chr11:64055812ENST000005398514790_110261.0321.0TransmembraneHelical%3B Name%3D3


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
IGHMBP2
GPR137


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to IGHMBP2-GPR137


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to IGHMBP2-GPR137


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource