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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:IKZF1-B2M

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: IKZF1-B2M
FusionPDB ID: 39386
FusionGDB2.0 ID: 39386
HgeneTgene
Gene symbol

IKZF1

B2M

Gene ID

10320

567

Gene nameIKAROS family zinc finger 1beta-2-microglobulin
SynonymsCVID13|Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1IMD43
Cytomap

7p12.2

15q21.1

Type of geneprotein-codingprotein-coding
DescriptionDNA-binding protein IkarosCLL-associated antigen KW-6ikaros family zinc finger protein 1lymphoid transcription factor LyF-1protein phosphatase 1, regulatory subunit 92zinc finger protein, subfamily 1A, 1 (Ikaros)beta-2-microglobulinbeta chain of MHC class I moleculesbeta-2-microglobin
Modification date2020032920200329
UniProtAcc

Q13422

P61769

Ensembl transtripts involved in fusion geneENST idsENST00000492782, ENST00000331340, 
ENST00000343574, ENST00000346667, 
ENST00000349824, ENST00000357364, 
ENST00000359197, ENST00000413698, 
ENST00000438033, ENST00000439701, 
ENST00000440768, 		ENST00000544417, 
ENST00000558401, ENST00000559916, 
ENST00000559220, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 7 X 6=33664 X 31 X 17=33728
# samples 871
** MAII scorelog2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(71/33728*10)=-5.56998393724517
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: IKZF1 [Title/Abstract] AND B2M [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)IKZF1(50367356)-B2M(45007620), # samples:1
Anticipated loss of major functional domain due to fusion event.IKZF1-B2M seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
IKZF1-B2M seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
IKZF1-B2M seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
IKZF1-B2M seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
IKZF1-B2M seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
IKZF1-B2M seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
IKZF1-B2M seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
IKZF1-B2M seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
IKZF1-B2M seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
IKZF1-B2M seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneB2M

GO:0002726

positive regulation of T cell cytokine production

24643698

TgeneB2M

GO:0007611

learning or memory

26147761

TgeneB2M

GO:0050680

negative regulation of epithelial cell proliferation

28213472

TgeneB2M

GO:0050768

negative regulation of neurogenesis

26147761

TgeneB2M

GO:0090647

modulation of age-related behavioral decline

26147761

TgeneB2M

GO:1900121

negative regulation of receptor binding

9465039

TgeneB2M

GO:1990000

amyloid fibril formation

28468825

TgeneB2M

GO:2000774

positive regulation of cellular senescence

28213472

TgeneB2M

GO:2000978

negative regulation of forebrain neuron differentiation

26147761


check buttonFusion gene breakpoints across IKZF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across B2M (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAW405039IKZF1chr7

50367356

+B2Mchr15

45007620

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000440768IKZF1chr750367356+ENST00000558401B2Mchr1545007620+189331553607184
ENST00000440768IKZF1chr750367356+ENST00000559916B2Mchr1545007620+129531553607184
ENST00000359197IKZF1chr750367356+ENST00000558401B2Mchr1545007620+189331553607184
ENST00000359197IKZF1chr750367356+ENST00000559916B2Mchr1545007620+129531553607184
ENST00000343574IKZF1chr750367356+ENST00000558401B2Mchr1545007620+189331553607184
ENST00000343574IKZF1chr750367356+ENST00000559916B2Mchr1545007620+129531553607184
ENST00000331340IKZF1chr750367356+ENST00000558401B2Mchr1545007620+189331553607184
ENST00000331340IKZF1chr750367356+ENST00000559916B2Mchr1545007620+129531553607184
ENST00000349824IKZF1chr750367356+ENST00000558401B2Mchr1545007620+189331553607184
ENST00000349824IKZF1chr750367356+ENST00000559916B2Mchr1545007620+129531553607184
ENST00000357364IKZF1chr750367356+ENST00000558401B2Mchr1545007620+189331553607184
ENST00000357364IKZF1chr750367356+ENST00000559916B2Mchr1545007620+129531553607184
ENST00000346667IKZF1chr750367356+ENST00000558401B2Mchr1545007620+189331553607184
ENST00000346667IKZF1chr750367356+ENST00000559916B2Mchr1545007620+129531553607184
ENST00000438033IKZF1chr750367356+ENST00000558401B2Mchr1545007620+1938360128652174
ENST00000438033IKZF1chr750367356+ENST00000559916B2Mchr1545007620+1340360128652174
ENST00000439701IKZF1chr750367356+ENST00000558401B2Mchr1545007620+1937359127651174
ENST00000439701IKZF1chr750367356+ENST00000559916B2Mchr1545007620+1339359127651174
ENST00000413698IKZF1chr750367356+ENST00000558401B2Mchr1545007620+194736929661210
ENST00000413698IKZF1chr750367356+ENST00000559916B2Mchr1545007620+134936929661210

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000440768ENST00000558401IKZF1chr750367356+B2Mchr1545007620+0.0015030230.998497
ENST00000440768ENST00000559916IKZF1chr750367356+B2Mchr1545007620+0.0028625870.9971374
ENST00000359197ENST00000558401IKZF1chr750367356+B2Mchr1545007620+0.0015030230.998497
ENST00000359197ENST00000559916IKZF1chr750367356+B2Mchr1545007620+0.0028625870.9971374
ENST00000343574ENST00000558401IKZF1chr750367356+B2Mchr1545007620+0.0015030230.998497
ENST00000343574ENST00000559916IKZF1chr750367356+B2Mchr1545007620+0.0028625870.9971374
ENST00000331340ENST00000558401IKZF1chr750367356+B2Mchr1545007620+0.0015030230.998497
ENST00000331340ENST00000559916IKZF1chr750367356+B2Mchr1545007620+0.0028625870.9971374
ENST00000349824ENST00000558401IKZF1chr750367356+B2Mchr1545007620+0.0015030230.998497
ENST00000349824ENST00000559916IKZF1chr750367356+B2Mchr1545007620+0.0028625870.9971374
ENST00000357364ENST00000558401IKZF1chr750367356+B2Mchr1545007620+0.0015030230.998497
ENST00000357364ENST00000559916IKZF1chr750367356+B2Mchr1545007620+0.0028625870.9971374
ENST00000346667ENST00000558401IKZF1chr750367356+B2Mchr1545007620+0.0015030230.998497
ENST00000346667ENST00000559916IKZF1chr750367356+B2Mchr1545007620+0.0028625870.9971374
ENST00000438033ENST00000558401IKZF1chr750367356+B2Mchr1545007620+0.0016938220.99830616
ENST00000438033ENST00000559916IKZF1chr750367356+B2Mchr1545007620+0.0024065120.99759346
ENST00000439701ENST00000558401IKZF1chr750367356+B2Mchr1545007620+0.0016531540.9983468
ENST00000439701ENST00000559916IKZF1chr750367356+B2Mchr1545007620+0.0025304610.99746954
ENST00000413698ENST00000558401IKZF1chr750367356+B2Mchr1545007620+0.001906910.99809307
ENST00000413698ENST00000559916IKZF1chr750367356+B2Mchr1545007620+0.0039423550.9960576

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>39386_39386_1_IKZF1-B2M_IKZF1_chr7_50367356_ENST00000331340_B2M_chr15_45007620_ENST00000558401_length(amino acids)=184AA_BP=87
MAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGTP
KIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKW

--------------------------------------------------------------

>39386_39386_2_IKZF1-B2M_IKZF1_chr7_50367356_ENST00000331340_B2M_chr15_45007620_ENST00000559916_length(amino acids)=184AA_BP=87
MAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGTP
KIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKW

--------------------------------------------------------------

>39386_39386_3_IKZF1-B2M_IKZF1_chr7_50367356_ENST00000343574_B2M_chr15_45007620_ENST00000558401_length(amino acids)=184AA_BP=87
MAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGTP
KIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKW

--------------------------------------------------------------

>39386_39386_4_IKZF1-B2M_IKZF1_chr7_50367356_ENST00000343574_B2M_chr15_45007620_ENST00000559916_length(amino acids)=184AA_BP=87
MAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGTP
KIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKW

--------------------------------------------------------------

>39386_39386_5_IKZF1-B2M_IKZF1_chr7_50367356_ENST00000346667_B2M_chr15_45007620_ENST00000558401_length(amino acids)=184AA_BP=87
MAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGTP
KIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKW

--------------------------------------------------------------

>39386_39386_6_IKZF1-B2M_IKZF1_chr7_50367356_ENST00000346667_B2M_chr15_45007620_ENST00000559916_length(amino acids)=184AA_BP=87
MAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGTP
KIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKW

--------------------------------------------------------------

>39386_39386_7_IKZF1-B2M_IKZF1_chr7_50367356_ENST00000349824_B2M_chr15_45007620_ENST00000558401_length(amino acids)=184AA_BP=87
MAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGTP
KIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKW

--------------------------------------------------------------

>39386_39386_8_IKZF1-B2M_IKZF1_chr7_50367356_ENST00000349824_B2M_chr15_45007620_ENST00000559916_length(amino acids)=184AA_BP=87
MAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGTP
KIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKW

--------------------------------------------------------------

>39386_39386_9_IKZF1-B2M_IKZF1_chr7_50367356_ENST00000357364_B2M_chr15_45007620_ENST00000558401_length(amino acids)=184AA_BP=87
MAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGTP
KIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKW

--------------------------------------------------------------

>39386_39386_10_IKZF1-B2M_IKZF1_chr7_50367356_ENST00000357364_B2M_chr15_45007620_ENST00000559916_length(amino acids)=184AA_BP=87
MAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGTP
KIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKW

--------------------------------------------------------------

>39386_39386_11_IKZF1-B2M_IKZF1_chr7_50367356_ENST00000359197_B2M_chr15_45007620_ENST00000558401_length(amino acids)=184AA_BP=87
MAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGTP
KIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKW

--------------------------------------------------------------

>39386_39386_12_IKZF1-B2M_IKZF1_chr7_50367356_ENST00000359197_B2M_chr15_45007620_ENST00000559916_length(amino acids)=184AA_BP=87
MAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGTP
KIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKW

--------------------------------------------------------------

>39386_39386_13_IKZF1-B2M_IKZF1_chr7_50367356_ENST00000413698_B2M_chr15_45007620_ENST00000558401_length(amino acids)=210AA_BP=113
MRQAPWVPARRIPAWAGRSAAARRASLAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEP
MPIPEDLSTTSGGQQSSKSDRVVGTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTE

--------------------------------------------------------------

>39386_39386_14_IKZF1-B2M_IKZF1_chr7_50367356_ENST00000413698_B2M_chr15_45007620_ENST00000559916_length(amino acids)=210AA_BP=113
MRQAPWVPARRIPAWAGRSAAARRASLAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEP
MPIPEDLSTTSGGQQSSKSDRVVGTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTE

--------------------------------------------------------------

>39386_39386_15_IKZF1-B2M_IKZF1_chr7_50367356_ENST00000438033_B2M_chr15_45007620_ENST00000558401_length(amino acids)=174AA_BP=77
MDLCGKGSSHLALARPRLVDNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGTPKIQVYSRHPA

--------------------------------------------------------------

>39386_39386_16_IKZF1-B2M_IKZF1_chr7_50367356_ENST00000438033_B2M_chr15_45007620_ENST00000559916_length(amino acids)=174AA_BP=77
MDLCGKGSSHLALARPRLVDNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGTPKIQVYSRHPA

--------------------------------------------------------------

>39386_39386_17_IKZF1-B2M_IKZF1_chr7_50367356_ENST00000439701_B2M_chr15_45007620_ENST00000558401_length(amino acids)=174AA_BP=77
MDLCGKGSSHLALARPRLVDNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGTPKIQVYSRHPA

--------------------------------------------------------------

>39386_39386_18_IKZF1-B2M_IKZF1_chr7_50367356_ENST00000439701_B2M_chr15_45007620_ENST00000559916_length(amino acids)=174AA_BP=77
MDLCGKGSSHLALARPRLVDNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGTPKIQVYSRHPA

--------------------------------------------------------------

>39386_39386_19_IKZF1-B2M_IKZF1_chr7_50367356_ENST00000440768_B2M_chr15_45007620_ENST00000558401_length(amino acids)=184AA_BP=87
MAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGTP
KIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKW

--------------------------------------------------------------

>39386_39386_20_IKZF1-B2M_IKZF1_chr7_50367356_ENST00000440768_B2M_chr15_45007620_ENST00000559916_length(amino acids)=184AA_BP=87
MAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGTP
KIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKW

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:50367356/chr15:45007620)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IKZF1

Q13422

B2M

P61769

FUNCTION: Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067, ECO:0000269|PubMed:19141594}.FUNCTION: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553). {ECO:0000269|PubMed:25356553}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneB2Mchr7:50367356chr15:45007620ENST000005584010425_11322.333333333333332498.0DomainNote=Ig-like C1-type
TgeneB2Mchr7:50367356chr15:45007620ENST000005599160325_11322.333333333333332120.0DomainNote=Ig-like C1-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIKZF1chr7:50367356chr15:45007620ENST00000331340+38373_37653.333333333333336520.0Compositional biasNote=Poly-Leu
HgeneIKZF1chr7:50367356chr15:45007620ENST00000343574+37373_37653.333333333333336433.0Compositional biasNote=Poly-Leu
HgeneIKZF1chr7:50367356chr15:45007620ENST00000346667+34373_37653.333333333333336290.0Compositional biasNote=Poly-Leu
HgeneIKZF1chr7:50367356chr15:45007620ENST00000349824+35373_37653.333333333333336377.0Compositional biasNote=Poly-Leu
HgeneIKZF1chr7:50367356chr15:45007620ENST00000357364+36373_37653.333333333333336433.0Compositional biasNote=Poly-Leu
HgeneIKZF1chr7:50367356chr15:45007620ENST00000359197+37373_37653.333333333333336478.0Compositional biasNote=Poly-Leu
HgeneIKZF1chr7:50367356chr15:45007620ENST00000438033+37373_37653.333333333333336433.0Compositional biasNote=Poly-Leu
HgeneIKZF1chr7:50367356chr15:45007620ENST00000439701+37373_37653.333333333333336478.0Compositional biasNote=Poly-Leu
HgeneIKZF1chr7:50367356chr15:45007620ENST00000440768+38373_37653.3333333333333361049.3333333333333Compositional biasNote=Poly-Leu
HgeneIKZF1chr7:50367356chr15:45007620ENST00000331340+38154_16353.333333333333336520.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367356chr15:45007620ENST00000331340+38180_19553.333333333333336520.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367356chr15:45007620ENST00000331340+38468_47153.333333333333336520.0RegionRequired for binding PP1CC
HgeneIKZF1chr7:50367356chr15:45007620ENST00000343574+37154_16353.333333333333336433.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367356chr15:45007620ENST00000343574+37180_19553.333333333333336433.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367356chr15:45007620ENST00000343574+37468_47153.333333333333336433.0RegionRequired for binding PP1CC
HgeneIKZF1chr7:50367356chr15:45007620ENST00000346667+34154_16353.333333333333336290.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367356chr15:45007620ENST00000346667+34180_19553.333333333333336290.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367356chr15:45007620ENST00000346667+34468_47153.333333333333336290.0RegionRequired for binding PP1CC
HgeneIKZF1chr7:50367356chr15:45007620ENST00000349824+35154_16353.333333333333336377.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367356chr15:45007620ENST00000349824+35180_19553.333333333333336377.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367356chr15:45007620ENST00000349824+35468_47153.333333333333336377.0RegionRequired for binding PP1CC
HgeneIKZF1chr7:50367356chr15:45007620ENST00000357364+36154_16353.333333333333336433.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367356chr15:45007620ENST00000357364+36180_19553.333333333333336433.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367356chr15:45007620ENST00000357364+36468_47153.333333333333336433.0RegionRequired for binding PP1CC
HgeneIKZF1chr7:50367356chr15:45007620ENST00000359197+37154_16353.333333333333336478.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367356chr15:45007620ENST00000359197+37180_19553.333333333333336478.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367356chr15:45007620ENST00000359197+37468_47153.333333333333336478.0RegionRequired for binding PP1CC
HgeneIKZF1chr7:50367356chr15:45007620ENST00000438033+37154_16353.333333333333336433.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367356chr15:45007620ENST00000438033+37180_19553.333333333333336433.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367356chr15:45007620ENST00000438033+37468_47153.333333333333336433.0RegionRequired for binding PP1CC
HgeneIKZF1chr7:50367356chr15:45007620ENST00000439701+37154_16353.333333333333336478.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367356chr15:45007620ENST00000439701+37180_19553.333333333333336478.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367356chr15:45007620ENST00000439701+37468_47153.333333333333336478.0RegionRequired for binding PP1CC
HgeneIKZF1chr7:50367356chr15:45007620ENST00000440768+38154_16353.3333333333333361049.3333333333333RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367356chr15:45007620ENST00000440768+38180_19553.3333333333333361049.3333333333333RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367356chr15:45007620ENST00000440768+38468_47153.3333333333333361049.3333333333333RegionRequired for binding PP1CC
HgeneIKZF1chr7:50367356chr15:45007620ENST00000331340+38117_13953.333333333333336520.0Zinc fingerC2H2-type 1
HgeneIKZF1chr7:50367356chr15:45007620ENST00000331340+38145_16753.333333333333336520.0Zinc fingerC2H2-type 2
HgeneIKZF1chr7:50367356chr15:45007620ENST00000331340+38173_19553.333333333333336520.0Zinc fingerC2H2-type 3
HgeneIKZF1chr7:50367356chr15:45007620ENST00000331340+38201_22453.333333333333336520.0Zinc fingerC2H2-type 4
HgeneIKZF1chr7:50367356chr15:45007620ENST00000331340+38462_48453.333333333333336520.0Zinc fingerC2H2-type 5
HgeneIKZF1chr7:50367356chr15:45007620ENST00000331340+38490_51453.333333333333336520.0Zinc fingerC2H2-type 6
HgeneIKZF1chr7:50367356chr15:45007620ENST00000343574+37117_13953.333333333333336433.0Zinc fingerC2H2-type 1
HgeneIKZF1chr7:50367356chr15:45007620ENST00000343574+37145_16753.333333333333336433.0Zinc fingerC2H2-type 2
HgeneIKZF1chr7:50367356chr15:45007620ENST00000343574+37173_19553.333333333333336433.0Zinc fingerC2H2-type 3
HgeneIKZF1chr7:50367356chr15:45007620ENST00000343574+37201_22453.333333333333336433.0Zinc fingerC2H2-type 4
HgeneIKZF1chr7:50367356chr15:45007620ENST00000343574+37462_48453.333333333333336433.0Zinc fingerC2H2-type 5
HgeneIKZF1chr7:50367356chr15:45007620ENST00000343574+37490_51453.333333333333336433.0Zinc fingerC2H2-type 6
HgeneIKZF1chr7:50367356chr15:45007620ENST00000346667+34117_13953.333333333333336290.0Zinc fingerC2H2-type 1
HgeneIKZF1chr7:50367356chr15:45007620ENST00000346667+34145_16753.333333333333336290.0Zinc fingerC2H2-type 2
HgeneIKZF1chr7:50367356chr15:45007620ENST00000346667+34173_19553.333333333333336290.0Zinc fingerC2H2-type 3
HgeneIKZF1chr7:50367356chr15:45007620ENST00000346667+34201_22453.333333333333336290.0Zinc fingerC2H2-type 4
HgeneIKZF1chr7:50367356chr15:45007620ENST00000346667+34462_48453.333333333333336290.0Zinc fingerC2H2-type 5
HgeneIKZF1chr7:50367356chr15:45007620ENST00000346667+34490_51453.333333333333336290.0Zinc fingerC2H2-type 6
HgeneIKZF1chr7:50367356chr15:45007620ENST00000349824+35117_13953.333333333333336377.0Zinc fingerC2H2-type 1
HgeneIKZF1chr7:50367356chr15:45007620ENST00000349824+35145_16753.333333333333336377.0Zinc fingerC2H2-type 2
HgeneIKZF1chr7:50367356chr15:45007620ENST00000349824+35173_19553.333333333333336377.0Zinc fingerC2H2-type 3
HgeneIKZF1chr7:50367356chr15:45007620ENST00000349824+35201_22453.333333333333336377.0Zinc fingerC2H2-type 4
HgeneIKZF1chr7:50367356chr15:45007620ENST00000349824+35462_48453.333333333333336377.0Zinc fingerC2H2-type 5
HgeneIKZF1chr7:50367356chr15:45007620ENST00000349824+35490_51453.333333333333336377.0Zinc fingerC2H2-type 6
HgeneIKZF1chr7:50367356chr15:45007620ENST00000357364+36117_13953.333333333333336433.0Zinc fingerC2H2-type 1
HgeneIKZF1chr7:50367356chr15:45007620ENST00000357364+36145_16753.333333333333336433.0Zinc fingerC2H2-type 2
HgeneIKZF1chr7:50367356chr15:45007620ENST00000357364+36173_19553.333333333333336433.0Zinc fingerC2H2-type 3
HgeneIKZF1chr7:50367356chr15:45007620ENST00000357364+36201_22453.333333333333336433.0Zinc fingerC2H2-type 4
HgeneIKZF1chr7:50367356chr15:45007620ENST00000357364+36462_48453.333333333333336433.0Zinc fingerC2H2-type 5
HgeneIKZF1chr7:50367356chr15:45007620ENST00000357364+36490_51453.333333333333336433.0Zinc fingerC2H2-type 6
HgeneIKZF1chr7:50367356chr15:45007620ENST00000359197+37117_13953.333333333333336478.0Zinc fingerC2H2-type 1
HgeneIKZF1chr7:50367356chr15:45007620ENST00000359197+37145_16753.333333333333336478.0Zinc fingerC2H2-type 2
HgeneIKZF1chr7:50367356chr15:45007620ENST00000359197+37173_19553.333333333333336478.0Zinc fingerC2H2-type 3
HgeneIKZF1chr7:50367356chr15:45007620ENST00000359197+37201_22453.333333333333336478.0Zinc fingerC2H2-type 4
HgeneIKZF1chr7:50367356chr15:45007620ENST00000359197+37462_48453.333333333333336478.0Zinc fingerC2H2-type 5
HgeneIKZF1chr7:50367356chr15:45007620ENST00000359197+37490_51453.333333333333336478.0Zinc fingerC2H2-type 6
HgeneIKZF1chr7:50367356chr15:45007620ENST00000438033+37117_13953.333333333333336433.0Zinc fingerC2H2-type 1
HgeneIKZF1chr7:50367356chr15:45007620ENST00000438033+37145_16753.333333333333336433.0Zinc fingerC2H2-type 2
HgeneIKZF1chr7:50367356chr15:45007620ENST00000438033+37173_19553.333333333333336433.0Zinc fingerC2H2-type 3
HgeneIKZF1chr7:50367356chr15:45007620ENST00000438033+37201_22453.333333333333336433.0Zinc fingerC2H2-type 4
HgeneIKZF1chr7:50367356chr15:45007620ENST00000438033+37462_48453.333333333333336433.0Zinc fingerC2H2-type 5
HgeneIKZF1chr7:50367356chr15:45007620ENST00000438033+37490_51453.333333333333336433.0Zinc fingerC2H2-type 6
HgeneIKZF1chr7:50367356chr15:45007620ENST00000439701+37117_13953.333333333333336478.0Zinc fingerC2H2-type 1
HgeneIKZF1chr7:50367356chr15:45007620ENST00000439701+37145_16753.333333333333336478.0Zinc fingerC2H2-type 2
HgeneIKZF1chr7:50367356chr15:45007620ENST00000439701+37173_19553.333333333333336478.0Zinc fingerC2H2-type 3
HgeneIKZF1chr7:50367356chr15:45007620ENST00000439701+37201_22453.333333333333336478.0Zinc fingerC2H2-type 4
HgeneIKZF1chr7:50367356chr15:45007620ENST00000439701+37462_48453.333333333333336478.0Zinc fingerC2H2-type 5
HgeneIKZF1chr7:50367356chr15:45007620ENST00000439701+37490_51453.333333333333336478.0Zinc fingerC2H2-type 6
HgeneIKZF1chr7:50367356chr15:45007620ENST00000440768+38117_13953.3333333333333361049.3333333333333Zinc fingerC2H2-type 1
HgeneIKZF1chr7:50367356chr15:45007620ENST00000440768+38145_16753.3333333333333361049.3333333333333Zinc fingerC2H2-type 2
HgeneIKZF1chr7:50367356chr15:45007620ENST00000440768+38173_19553.3333333333333361049.3333333333333Zinc fingerC2H2-type 3
HgeneIKZF1chr7:50367356chr15:45007620ENST00000440768+38201_22453.3333333333333361049.3333333333333Zinc fingerC2H2-type 4
HgeneIKZF1chr7:50367356chr15:45007620ENST00000440768+38462_48453.3333333333333361049.3333333333333Zinc fingerC2H2-type 5
HgeneIKZF1chr7:50367356chr15:45007620ENST00000440768+38490_51453.3333333333333361049.3333333333333Zinc fingerC2H2-type 6


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
IKZF1
B2M


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to IKZF1-B2M


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to IKZF1-B2M


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource