UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:IKZF1-LRBA

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: IKZF1-LRBA
FusionPDB ID: 39390
FusionGDB2.0 ID: 39390
HgeneTgene
Gene symbol

IKZF1

LRBA

Gene ID

10320

987

Gene nameIKAROS family zinc finger 1LPS responsive beige-like anchor protein
SynonymsCVID13|Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1BGL|CDC4L|CVID8|LAB300|LBA
Cytomap

7p12.2

4q31.3

Type of geneprotein-codingprotein-coding
DescriptionDNA-binding protein IkarosCLL-associated antigen KW-6ikaros family zinc finger protein 1lymphoid transcription factor LyF-1protein phosphatase 1, regulatory subunit 92zinc finger protein, subfamily 1A, 1 (Ikaros)lipopolysaccharide-responsive and beige-like anchor proteinCDC4-like proteinLPS-responsive vesicle trafficking, beach and anchor containingvesicle trafficking, beach and anchor containing
Modification date2020032920200320
UniProtAcc

Q13422

P50851

Ensembl transtripts involved in fusion geneENST idsENST00000492782, ENST00000331340, 
ENST00000343574, ENST00000346667, 
ENST00000349824, ENST00000357364, 
ENST00000359197, ENST00000413698, 
ENST00000438033, ENST00000439701, 
ENST00000440768, 		ENST00000510413, 
ENST00000535741, ENST00000357115, 
ENST00000503716, ENST00000507224, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 7 X 6=33625 X 25 X 10=6250
# samples 827
** MAII scorelog2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/6250*10)=-4.53282487738598
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: IKZF1 [Title/Abstract] AND LRBA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)IKZF1(50367353)-LRBA(151207186), # samples:3
Anticipated loss of major functional domain due to fusion event.IKZF1-LRBA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
IKZF1-LRBA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across IKZF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LRBA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A27H-01AIKZF1chr7

50367353

-LRBAchr4

151207186

-
ChimerDB4BRCATCGA-D8-A27H-01AIKZF1chr7

50367353

+LRBAchr4

151207186

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000440768IKZF1chr750367353+ENST00000535741LRBAchr4151207186-213731553856267
ENST00000440768IKZF1chr750367353+ENST00000510413LRBAchr4151207186-204831553856267
ENST00000359197IKZF1chr750367353+ENST00000535741LRBAchr4151207186-213731553856267
ENST00000359197IKZF1chr750367353+ENST00000510413LRBAchr4151207186-204831553856267
ENST00000343574IKZF1chr750367353+ENST00000535741LRBAchr4151207186-213731553856267
ENST00000343574IKZF1chr750367353+ENST00000510413LRBAchr4151207186-204831553856267
ENST00000331340IKZF1chr750367353+ENST00000535741LRBAchr4151207186-213731553856267
ENST00000331340IKZF1chr750367353+ENST00000510413LRBAchr4151207186-204831553856267
ENST00000349824IKZF1chr750367353+ENST00000535741LRBAchr4151207186-213731553856267
ENST00000349824IKZF1chr750367353+ENST00000510413LRBAchr4151207186-204831553856267
ENST00000357364IKZF1chr750367353+ENST00000535741LRBAchr4151207186-213731553856267
ENST00000357364IKZF1chr750367353+ENST00000510413LRBAchr4151207186-204831553856267
ENST00000346667IKZF1chr750367353+ENST00000535741LRBAchr4151207186-213731553856267
ENST00000346667IKZF1chr750367353+ENST00000510413LRBAchr4151207186-204831553856267
ENST00000438033IKZF1chr750367353+ENST00000535741LRBAchr4151207186-2182360128901257
ENST00000438033IKZF1chr750367353+ENST00000510413LRBAchr4151207186-2093360128901257
ENST00000439701IKZF1chr750367353+ENST00000535741LRBAchr4151207186-2181359127900257
ENST00000439701IKZF1chr750367353+ENST00000510413LRBAchr4151207186-2092359127900257
ENST00000413698IKZF1chr750367353+ENST00000535741LRBAchr4151207186-219136929910293
ENST00000413698IKZF1chr750367353+ENST00000510413LRBAchr4151207186-210236929910293

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000440768ENST00000535741IKZF1chr750367353+LRBAchr4151207186-0.0006921890.99930775
ENST00000440768ENST00000510413IKZF1chr750367353+LRBAchr4151207186-0.0007535310.9992465
ENST00000359197ENST00000535741IKZF1chr750367353+LRBAchr4151207186-0.0006921890.99930775
ENST00000359197ENST00000510413IKZF1chr750367353+LRBAchr4151207186-0.0007535310.9992465
ENST00000343574ENST00000535741IKZF1chr750367353+LRBAchr4151207186-0.0006921890.99930775
ENST00000343574ENST00000510413IKZF1chr750367353+LRBAchr4151207186-0.0007535310.9992465
ENST00000331340ENST00000535741IKZF1chr750367353+LRBAchr4151207186-0.0006921890.99930775
ENST00000331340ENST00000510413IKZF1chr750367353+LRBAchr4151207186-0.0007535310.9992465
ENST00000349824ENST00000535741IKZF1chr750367353+LRBAchr4151207186-0.0006921890.99930775
ENST00000349824ENST00000510413IKZF1chr750367353+LRBAchr4151207186-0.0007535310.9992465
ENST00000357364ENST00000535741IKZF1chr750367353+LRBAchr4151207186-0.0006921890.99930775
ENST00000357364ENST00000510413IKZF1chr750367353+LRBAchr4151207186-0.0007535310.9992465
ENST00000346667ENST00000535741IKZF1chr750367353+LRBAchr4151207186-0.0006921890.99930775
ENST00000346667ENST00000510413IKZF1chr750367353+LRBAchr4151207186-0.0007535310.9992465
ENST00000438033ENST00000535741IKZF1chr750367353+LRBAchr4151207186-0.0006158890.99938405
ENST00000438033ENST00000510413IKZF1chr750367353+LRBAchr4151207186-0.0006533010.9993467
ENST00000439701ENST00000535741IKZF1chr750367353+LRBAchr4151207186-0.0005774270.99942255
ENST00000439701ENST00000510413IKZF1chr750367353+LRBAchr4151207186-0.0006195920.99938035
ENST00000413698ENST00000535741IKZF1chr750367353+LRBAchr4151207186-0.0006643180.9993357
ENST00000413698ENST00000510413IKZF1chr750367353+LRBAchr4151207186-0.0007199040.99928015

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>39390_39390_1_IKZF1-LRBA_IKZF1_chr7_50367353_ENST00000331340_LRBA_chr4_151207186_ENST00000510413_length(amino acids)=267AA_BP=87
MAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGET
AAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATM

--------------------------------------------------------------

>39390_39390_2_IKZF1-LRBA_IKZF1_chr7_50367353_ENST00000331340_LRBA_chr4_151207186_ENST00000535741_length(amino acids)=267AA_BP=87
MAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGET
AAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATM

--------------------------------------------------------------

>39390_39390_3_IKZF1-LRBA_IKZF1_chr7_50367353_ENST00000343574_LRBA_chr4_151207186_ENST00000510413_length(amino acids)=267AA_BP=87
MAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGET
AAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATM

--------------------------------------------------------------

>39390_39390_4_IKZF1-LRBA_IKZF1_chr7_50367353_ENST00000343574_LRBA_chr4_151207186_ENST00000535741_length(amino acids)=267AA_BP=87
MAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGET
AAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATM

--------------------------------------------------------------

>39390_39390_5_IKZF1-LRBA_IKZF1_chr7_50367353_ENST00000346667_LRBA_chr4_151207186_ENST00000510413_length(amino acids)=267AA_BP=87
MAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGET
AAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATM

--------------------------------------------------------------

>39390_39390_6_IKZF1-LRBA_IKZF1_chr7_50367353_ENST00000346667_LRBA_chr4_151207186_ENST00000535741_length(amino acids)=267AA_BP=87
MAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGET
AAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATM

--------------------------------------------------------------

>39390_39390_7_IKZF1-LRBA_IKZF1_chr7_50367353_ENST00000349824_LRBA_chr4_151207186_ENST00000510413_length(amino acids)=267AA_BP=87
MAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGET
AAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATM

--------------------------------------------------------------

>39390_39390_8_IKZF1-LRBA_IKZF1_chr7_50367353_ENST00000349824_LRBA_chr4_151207186_ENST00000535741_length(amino acids)=267AA_BP=87
MAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGET
AAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATM

--------------------------------------------------------------

>39390_39390_9_IKZF1-LRBA_IKZF1_chr7_50367353_ENST00000357364_LRBA_chr4_151207186_ENST00000510413_length(amino acids)=267AA_BP=87
MAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGET
AAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATM

--------------------------------------------------------------

>39390_39390_10_IKZF1-LRBA_IKZF1_chr7_50367353_ENST00000357364_LRBA_chr4_151207186_ENST00000535741_length(amino acids)=267AA_BP=87
MAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGET
AAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATM

--------------------------------------------------------------

>39390_39390_11_IKZF1-LRBA_IKZF1_chr7_50367353_ENST00000359197_LRBA_chr4_151207186_ENST00000510413_length(amino acids)=267AA_BP=87
MAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGET
AAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATM

--------------------------------------------------------------

>39390_39390_12_IKZF1-LRBA_IKZF1_chr7_50367353_ENST00000359197_LRBA_chr4_151207186_ENST00000535741_length(amino acids)=267AA_BP=87
MAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGET
AAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATM

--------------------------------------------------------------

>39390_39390_13_IKZF1-LRBA_IKZF1_chr7_50367353_ENST00000413698_LRBA_chr4_151207186_ENST00000510413_length(amino acids)=293AA_BP=113
MRQAPWVPARRIPAWAGRSAAARRASLAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEP
MPIPEDLSTTSGGQQSSKSDRVVGETAAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASR
EGHCVIFYENGLFCTFSVNGKLQATMETDDNIRAIQLSRDGQYLLTGGDRGVVVVRQVSDLKQLFAYPGCDAGIRAMALSYDQRCIISGM

--------------------------------------------------------------

>39390_39390_14_IKZF1-LRBA_IKZF1_chr7_50367353_ENST00000413698_LRBA_chr4_151207186_ENST00000535741_length(amino acids)=293AA_BP=113
MRQAPWVPARRIPAWAGRSAAARRASLAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEP
MPIPEDLSTTSGGQQSSKSDRVVGETAAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASR
EGHCVIFYENGLFCTFSVNGKLQATMETDDNIRAIQLSRDGQYLLTGGDRGVVVVRQVSDLKQLFAYPGCDAGIRAMALSYDQRCIISGM

--------------------------------------------------------------

>39390_39390_15_IKZF1-LRBA_IKZF1_chr7_50367353_ENST00000438033_LRBA_chr4_151207186_ENST00000510413_length(amino acids)=257AA_BP=77
MDLCGKGSSHLALARPRLVDNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGETAAPRAILTGH
DYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATMETDDNIRAIQ

--------------------------------------------------------------

>39390_39390_16_IKZF1-LRBA_IKZF1_chr7_50367353_ENST00000438033_LRBA_chr4_151207186_ENST00000535741_length(amino acids)=257AA_BP=77
MDLCGKGSSHLALARPRLVDNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGETAAPRAILTGH
DYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATMETDDNIRAIQ

--------------------------------------------------------------

>39390_39390_17_IKZF1-LRBA_IKZF1_chr7_50367353_ENST00000439701_LRBA_chr4_151207186_ENST00000510413_length(amino acids)=257AA_BP=77
MDLCGKGSSHLALARPRLVDNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGETAAPRAILTGH
DYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATMETDDNIRAIQ

--------------------------------------------------------------

>39390_39390_18_IKZF1-LRBA_IKZF1_chr7_50367353_ENST00000439701_LRBA_chr4_151207186_ENST00000535741_length(amino acids)=257AA_BP=77
MDLCGKGSSHLALARPRLVDNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGETAAPRAILTGH
DYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATMETDDNIRAIQ

--------------------------------------------------------------

>39390_39390_19_IKZF1-LRBA_IKZF1_chr7_50367353_ENST00000440768_LRBA_chr4_151207186_ENST00000510413_length(amino acids)=267AA_BP=87
MAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGET
AAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATM

--------------------------------------------------------------

>39390_39390_20_IKZF1-LRBA_IKZF1_chr7_50367353_ENST00000440768_LRBA_chr4_151207186_ENST00000535741_length(amino acids)=267AA_BP=87
MAGQREPRLRGCSSHPRISLGPKARRTNPHNLRTMDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVGET
AAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATM

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:50367353/chr4:151207186)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IKZF1

Q13422

LRBA

P50851

FUNCTION: Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067, ECO:0000269|PubMed:19141594}.FUNCTION: May be involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLRBAchr7:50367353chr4:151207186ENST0000035711553582695_27352683.33333333333352864.0RepeatNote=WD 4
TgeneLRBAchr7:50367353chr4:151207186ENST0000035711553582777_28162683.33333333333352864.0RepeatNote=WD 5
TgeneLRBAchr7:50367353chr4:151207186ENST0000035711553582819_28582683.33333333333352864.0RepeatNote=WD 6
TgeneLRBAchr7:50367353chr4:151207186ENST0000051041352572695_27352671.33333333333352852.0RepeatNote=WD 4
TgeneLRBAchr7:50367353chr4:151207186ENST0000051041352572777_28162671.33333333333352852.0RepeatNote=WD 5
TgeneLRBAchr7:50367353chr4:151207186ENST0000051041352572819_28582671.33333333333352852.0RepeatNote=WD 6

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIKZF1chr7:50367353chr4:151207186ENST00000331340+38373_37653.333333333333336520.0Compositional biasNote=Poly-Leu
HgeneIKZF1chr7:50367353chr4:151207186ENST00000343574+37373_37653.333333333333336433.0Compositional biasNote=Poly-Leu
HgeneIKZF1chr7:50367353chr4:151207186ENST00000346667+34373_37653.333333333333336290.0Compositional biasNote=Poly-Leu
HgeneIKZF1chr7:50367353chr4:151207186ENST00000349824+35373_37653.333333333333336377.0Compositional biasNote=Poly-Leu
HgeneIKZF1chr7:50367353chr4:151207186ENST00000357364+36373_37653.333333333333336433.0Compositional biasNote=Poly-Leu
HgeneIKZF1chr7:50367353chr4:151207186ENST00000359197+37373_37653.333333333333336478.0Compositional biasNote=Poly-Leu
HgeneIKZF1chr7:50367353chr4:151207186ENST00000438033+37373_37653.333333333333336433.0Compositional biasNote=Poly-Leu
HgeneIKZF1chr7:50367353chr4:151207186ENST00000439701+37373_37653.333333333333336478.0Compositional biasNote=Poly-Leu
HgeneIKZF1chr7:50367353chr4:151207186ENST00000440768+38373_37653.3333333333333361049.3333333333333Compositional biasNote=Poly-Leu
HgeneIKZF1chr7:50367353chr4:151207186ENST00000331340+38154_16353.333333333333336520.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367353chr4:151207186ENST00000331340+38180_19553.333333333333336520.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367353chr4:151207186ENST00000331340+38468_47153.333333333333336520.0RegionRequired for binding PP1CC
HgeneIKZF1chr7:50367353chr4:151207186ENST00000343574+37154_16353.333333333333336433.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367353chr4:151207186ENST00000343574+37180_19553.333333333333336433.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367353chr4:151207186ENST00000343574+37468_47153.333333333333336433.0RegionRequired for binding PP1CC
HgeneIKZF1chr7:50367353chr4:151207186ENST00000346667+34154_16353.333333333333336290.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367353chr4:151207186ENST00000346667+34180_19553.333333333333336290.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367353chr4:151207186ENST00000346667+34468_47153.333333333333336290.0RegionRequired for binding PP1CC
HgeneIKZF1chr7:50367353chr4:151207186ENST00000349824+35154_16353.333333333333336377.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367353chr4:151207186ENST00000349824+35180_19553.333333333333336377.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367353chr4:151207186ENST00000349824+35468_47153.333333333333336377.0RegionRequired for binding PP1CC
HgeneIKZF1chr7:50367353chr4:151207186ENST00000357364+36154_16353.333333333333336433.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367353chr4:151207186ENST00000357364+36180_19553.333333333333336433.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367353chr4:151207186ENST00000357364+36468_47153.333333333333336433.0RegionRequired for binding PP1CC
HgeneIKZF1chr7:50367353chr4:151207186ENST00000359197+37154_16353.333333333333336478.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367353chr4:151207186ENST00000359197+37180_19553.333333333333336478.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367353chr4:151207186ENST00000359197+37468_47153.333333333333336478.0RegionRequired for binding PP1CC
HgeneIKZF1chr7:50367353chr4:151207186ENST00000438033+37154_16353.333333333333336433.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367353chr4:151207186ENST00000438033+37180_19553.333333333333336433.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367353chr4:151207186ENST00000438033+37468_47153.333333333333336433.0RegionRequired for binding PP1CC
HgeneIKZF1chr7:50367353chr4:151207186ENST00000439701+37154_16353.333333333333336478.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367353chr4:151207186ENST00000439701+37180_19553.333333333333336478.0RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367353chr4:151207186ENST00000439701+37468_47153.333333333333336478.0RegionRequired for binding PP1CC
HgeneIKZF1chr7:50367353chr4:151207186ENST00000440768+38154_16353.3333333333333361049.3333333333333RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367353chr4:151207186ENST00000440768+38180_19553.3333333333333361049.3333333333333RegionRequired for both high-affinity DNA binding and pericentromeric heterochromatin localization
HgeneIKZF1chr7:50367353chr4:151207186ENST00000440768+38468_47153.3333333333333361049.3333333333333RegionRequired for binding PP1CC
HgeneIKZF1chr7:50367353chr4:151207186ENST00000331340+38117_13953.333333333333336520.0Zinc fingerC2H2-type 1
HgeneIKZF1chr7:50367353chr4:151207186ENST00000331340+38145_16753.333333333333336520.0Zinc fingerC2H2-type 2
HgeneIKZF1chr7:50367353chr4:151207186ENST00000331340+38173_19553.333333333333336520.0Zinc fingerC2H2-type 3
HgeneIKZF1chr7:50367353chr4:151207186ENST00000331340+38201_22453.333333333333336520.0Zinc fingerC2H2-type 4
HgeneIKZF1chr7:50367353chr4:151207186ENST00000331340+38462_48453.333333333333336520.0Zinc fingerC2H2-type 5
HgeneIKZF1chr7:50367353chr4:151207186ENST00000331340+38490_51453.333333333333336520.0Zinc fingerC2H2-type 6
HgeneIKZF1chr7:50367353chr4:151207186ENST00000343574+37117_13953.333333333333336433.0Zinc fingerC2H2-type 1
HgeneIKZF1chr7:50367353chr4:151207186ENST00000343574+37145_16753.333333333333336433.0Zinc fingerC2H2-type 2
HgeneIKZF1chr7:50367353chr4:151207186ENST00000343574+37173_19553.333333333333336433.0Zinc fingerC2H2-type 3
HgeneIKZF1chr7:50367353chr4:151207186ENST00000343574+37201_22453.333333333333336433.0Zinc fingerC2H2-type 4
HgeneIKZF1chr7:50367353chr4:151207186ENST00000343574+37462_48453.333333333333336433.0Zinc fingerC2H2-type 5
HgeneIKZF1chr7:50367353chr4:151207186ENST00000343574+37490_51453.333333333333336433.0Zinc fingerC2H2-type 6
HgeneIKZF1chr7:50367353chr4:151207186ENST00000346667+34117_13953.333333333333336290.0Zinc fingerC2H2-type 1
HgeneIKZF1chr7:50367353chr4:151207186ENST00000346667+34145_16753.333333333333336290.0Zinc fingerC2H2-type 2
HgeneIKZF1chr7:50367353chr4:151207186ENST00000346667+34173_19553.333333333333336290.0Zinc fingerC2H2-type 3
HgeneIKZF1chr7:50367353chr4:151207186ENST00000346667+34201_22453.333333333333336290.0Zinc fingerC2H2-type 4
HgeneIKZF1chr7:50367353chr4:151207186ENST00000346667+34462_48453.333333333333336290.0Zinc fingerC2H2-type 5
HgeneIKZF1chr7:50367353chr4:151207186ENST00000346667+34490_51453.333333333333336290.0Zinc fingerC2H2-type 6
HgeneIKZF1chr7:50367353chr4:151207186ENST00000349824+35117_13953.333333333333336377.0Zinc fingerC2H2-type 1
HgeneIKZF1chr7:50367353chr4:151207186ENST00000349824+35145_16753.333333333333336377.0Zinc fingerC2H2-type 2
HgeneIKZF1chr7:50367353chr4:151207186ENST00000349824+35173_19553.333333333333336377.0Zinc fingerC2H2-type 3
HgeneIKZF1chr7:50367353chr4:151207186ENST00000349824+35201_22453.333333333333336377.0Zinc fingerC2H2-type 4
HgeneIKZF1chr7:50367353chr4:151207186ENST00000349824+35462_48453.333333333333336377.0Zinc fingerC2H2-type 5
HgeneIKZF1chr7:50367353chr4:151207186ENST00000349824+35490_51453.333333333333336377.0Zinc fingerC2H2-type 6
HgeneIKZF1chr7:50367353chr4:151207186ENST00000357364+36117_13953.333333333333336433.0Zinc fingerC2H2-type 1
HgeneIKZF1chr7:50367353chr4:151207186ENST00000357364+36145_16753.333333333333336433.0Zinc fingerC2H2-type 2
HgeneIKZF1chr7:50367353chr4:151207186ENST00000357364+36173_19553.333333333333336433.0Zinc fingerC2H2-type 3
HgeneIKZF1chr7:50367353chr4:151207186ENST00000357364+36201_22453.333333333333336433.0Zinc fingerC2H2-type 4
HgeneIKZF1chr7:50367353chr4:151207186ENST00000357364+36462_48453.333333333333336433.0Zinc fingerC2H2-type 5
HgeneIKZF1chr7:50367353chr4:151207186ENST00000357364+36490_51453.333333333333336433.0Zinc fingerC2H2-type 6
HgeneIKZF1chr7:50367353chr4:151207186ENST00000359197+37117_13953.333333333333336478.0Zinc fingerC2H2-type 1
HgeneIKZF1chr7:50367353chr4:151207186ENST00000359197+37145_16753.333333333333336478.0Zinc fingerC2H2-type 2
HgeneIKZF1chr7:50367353chr4:151207186ENST00000359197+37173_19553.333333333333336478.0Zinc fingerC2H2-type 3
HgeneIKZF1chr7:50367353chr4:151207186ENST00000359197+37201_22453.333333333333336478.0Zinc fingerC2H2-type 4
HgeneIKZF1chr7:50367353chr4:151207186ENST00000359197+37462_48453.333333333333336478.0Zinc fingerC2H2-type 5
HgeneIKZF1chr7:50367353chr4:151207186ENST00000359197+37490_51453.333333333333336478.0Zinc fingerC2H2-type 6
HgeneIKZF1chr7:50367353chr4:151207186ENST00000438033+37117_13953.333333333333336433.0Zinc fingerC2H2-type 1
HgeneIKZF1chr7:50367353chr4:151207186ENST00000438033+37145_16753.333333333333336433.0Zinc fingerC2H2-type 2
HgeneIKZF1chr7:50367353chr4:151207186ENST00000438033+37173_19553.333333333333336433.0Zinc fingerC2H2-type 3
HgeneIKZF1chr7:50367353chr4:151207186ENST00000438033+37201_22453.333333333333336433.0Zinc fingerC2H2-type 4
HgeneIKZF1chr7:50367353chr4:151207186ENST00000438033+37462_48453.333333333333336433.0Zinc fingerC2H2-type 5
HgeneIKZF1chr7:50367353chr4:151207186ENST00000438033+37490_51453.333333333333336433.0Zinc fingerC2H2-type 6
HgeneIKZF1chr7:50367353chr4:151207186ENST00000439701+37117_13953.333333333333336478.0Zinc fingerC2H2-type 1
HgeneIKZF1chr7:50367353chr4:151207186ENST00000439701+37145_16753.333333333333336478.0Zinc fingerC2H2-type 2
HgeneIKZF1chr7:50367353chr4:151207186ENST00000439701+37173_19553.333333333333336478.0Zinc fingerC2H2-type 3
HgeneIKZF1chr7:50367353chr4:151207186ENST00000439701+37201_22453.333333333333336478.0Zinc fingerC2H2-type 4
HgeneIKZF1chr7:50367353chr4:151207186ENST00000439701+37462_48453.333333333333336478.0Zinc fingerC2H2-type 5
HgeneIKZF1chr7:50367353chr4:151207186ENST00000439701+37490_51453.333333333333336478.0Zinc fingerC2H2-type 6
HgeneIKZF1chr7:50367353chr4:151207186ENST00000440768+38117_13953.3333333333333361049.3333333333333Zinc fingerC2H2-type 1
HgeneIKZF1chr7:50367353chr4:151207186ENST00000440768+38145_16753.3333333333333361049.3333333333333Zinc fingerC2H2-type 2
HgeneIKZF1chr7:50367353chr4:151207186ENST00000440768+38173_19553.3333333333333361049.3333333333333Zinc fingerC2H2-type 3
HgeneIKZF1chr7:50367353chr4:151207186ENST00000440768+38201_22453.3333333333333361049.3333333333333Zinc fingerC2H2-type 4
HgeneIKZF1chr7:50367353chr4:151207186ENST00000440768+38462_48453.3333333333333361049.3333333333333Zinc fingerC2H2-type 5
HgeneIKZF1chr7:50367353chr4:151207186ENST00000440768+38490_51453.3333333333333361049.3333333333333Zinc fingerC2H2-type 6
TgeneLRBAchr7:50367353chr4:151207186ENST0000035711553581006_10532683.33333333333352864.0Coiled coilOntology_term=ECO:0000255
TgeneLRBAchr7:50367353chr4:151207186ENST0000051041352571006_10532671.33333333333352852.0Coiled coilOntology_term=ECO:0000255
TgeneLRBAchr7:50367353chr4:151207186ENST0000035711553581990_19942683.33333333333352864.0Compositional biasNote=Poly-Arg
TgeneLRBAchr7:50367353chr4:151207186ENST0000051041352571990_19942671.33333333333352852.0Compositional biasNote=Poly-Arg
TgeneLRBAchr7:50367353chr4:151207186ENST0000035711553582073_21812683.33333333333352864.0DomainBEACH-type PH
TgeneLRBAchr7:50367353chr4:151207186ENST0000035711553582200_24892683.33333333333352864.0DomainBEACH
TgeneLRBAchr7:50367353chr4:151207186ENST0000051041352572073_21812671.33333333333352852.0DomainBEACH-type PH
TgeneLRBAchr7:50367353chr4:151207186ENST0000051041352572200_24892671.33333333333352852.0DomainBEACH
TgeneLRBAchr7:50367353chr4:151207186ENST0000035711553581301_13432683.33333333333352864.0RepeatNote=WD 1
TgeneLRBAchr7:50367353chr4:151207186ENST0000035711553582591_26332683.33333333333352864.0RepeatNote=WD 2
TgeneLRBAchr7:50367353chr4:151207186ENST0000035711553582636_26792683.33333333333352864.0RepeatNote=WD 3
TgeneLRBAchr7:50367353chr4:151207186ENST0000051041352571301_13432671.33333333333352852.0RepeatNote=WD 1
TgeneLRBAchr7:50367353chr4:151207186ENST0000051041352572591_26332671.33333333333352852.0RepeatNote=WD 2
TgeneLRBAchr7:50367353chr4:151207186ENST0000051041352572636_26792671.33333333333352852.0RepeatNote=WD 3
TgeneLRBAchr7:50367353chr4:151207186ENST0000035711553581531_15482683.33333333333352864.0TransmembraneHelical
TgeneLRBAchr7:50367353chr4:151207186ENST0000051041352571531_15482671.33333333333352852.0TransmembraneHelical


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
IKZF1
LRBA


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to IKZF1-LRBA


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to IKZF1-LRBA


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource