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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:IKZF3-SRCIN1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: IKZF3-SRCIN1
FusionPDB ID: 39410
FusionGDB2.0 ID: 39410
HgeneTgene
Gene symbol

IKZF3

SRCIN1

Gene ID

22806

80725

Gene nameIKAROS family zinc finger 3SRC kinase signaling inhibitor 1
SynonymsAIO|AIOLOS|ZNFN1A3P140|SNIP
Cytomap

17q12-q21.1

17q12

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein Aioloszinc finger DNA binding protein Aioloszinc finger protein, subfamily 1A, 3 (Aiolos)SRC kinase signaling inhibitor 1P130Cas-associated proteinSNAP-25-interacting proteinSNAP25-interacting proteinp140Cap
Modification date2020032720200320
UniProtAcc

Q9UKT9

.
Ensembl transtripts involved in fusion geneENST idsENST00000346243, ENST00000346872, 
ENST00000350532, ENST00000351680, 
ENST00000377944, ENST00000377945, 
ENST00000377952, ENST00000377958, 
ENST00000394189, ENST00000439016, 
ENST00000467757, ENST00000439167, 
ENST00000535189, ENST00000583368, 
ENST00000264659, ENST00000398579, 
ENST00000578925, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 9 X 7=63012 X 10 X 6=720
# samples 1111
** MAII scorelog2(11/630*10)=-2.51784830486262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/720*10)=-2.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: IKZF3 [Title/Abstract] AND SRCIN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)IKZF3(37985640)-SRCIN1(36752382), # samples:2
Anticipated loss of major functional domain due to fusion event.IKZF3-SRCIN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
IKZF3-SRCIN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
IKZF3-SRCIN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
IKZF3-SRCIN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSRCIN1

GO:0061098

positive regulation of protein tyrosine kinase activity

17525734

TgeneSRCIN1

GO:0061099

negative regulation of protein tyrosine kinase activity

17525734


check buttonFusion gene breakpoints across IKZF3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SRCIN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-ZF-AA4T-01AIKZF3chr17

37985640

-SRCIN1chr17

36735044

-
ChimerDB4BLCATCGA-ZF-AA4T-01AIKZF3chr17

37985640

-SRCIN1chr17

36752382

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000346872IKZF3chr1737985640-ENST00000264659SRCIN1chr1736735044-70362256237541230
ENST00000346872IKZF3chr1737985640-ENST00000578925SRCIN1chr1736735044-47102256238561264
ENST00000394189IKZF3chr1737985640-ENST00000264659SRCIN1chr1736735044-70362256237541230
ENST00000394189IKZF3chr1737985640-ENST00000578925SRCIN1chr1736735044-47102256238561264
ENST00000377944IKZF3chr1737985640-ENST00000264659SRCIN1chr1736735044-70362256237541230
ENST00000377944IKZF3chr1737985640-ENST00000578925SRCIN1chr1736735044-47102256238561264
ENST00000377945IKZF3chr1737985640-ENST00000264659SRCIN1chr1736735044-70362256237541230
ENST00000377945IKZF3chr1737985640-ENST00000578925SRCIN1chr1736735044-47102256238561264
ENST00000377952IKZF3chr1737985640-ENST00000264659SRCIN1chr1736735044-70362256237541230
ENST00000377952IKZF3chr1737985640-ENST00000578925SRCIN1chr1736735044-47102256238561264
ENST00000377958IKZF3chr1737985640-ENST00000264659SRCIN1chr1736735044-70362256237541230
ENST00000377958IKZF3chr1737985640-ENST00000578925SRCIN1chr1736735044-47102256238561264
ENST00000346243IKZF3chr1737985640-ENST00000264659SRCIN1chr1736735044-6974163036921230
ENST00000346243IKZF3chr1737985640-ENST00000578925SRCIN1chr1736735044-4648163037941264
ENST00000350532IKZF3chr1737985640-ENST00000264659SRCIN1chr1736735044-6974163036921230
ENST00000350532IKZF3chr1737985640-ENST00000578925SRCIN1chr1736735044-4648163037941264
ENST00000351680IKZF3chr1737985640-ENST00000264659SRCIN1chr1736735044-6974163036921230
ENST00000351680IKZF3chr1737985640-ENST00000578925SRCIN1chr1736735044-4648163037941264
ENST00000467757IKZF3chr1737985640-ENST00000264659SRCIN1chr1736735044-6974163036921230
ENST00000467757IKZF3chr1737985640-ENST00000578925SRCIN1chr1736735044-4648163037941264
ENST00000439016IKZF3chr1737985640-ENST00000264659SRCIN1chr1736735044-6975164136931230
ENST00000439016IKZF3chr1737985640-ENST00000578925SRCIN1chr1736735044-4649164137951264

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000346872ENST00000264659IKZF3chr1737985640-SRCIN1chr1736735044-0.0006171430.99938285
ENST00000346872ENST00000578925IKZF3chr1737985640-SRCIN1chr1736735044-0.0038010120.99619895
ENST00000394189ENST00000264659IKZF3chr1737985640-SRCIN1chr1736735044-0.0006171430.99938285
ENST00000394189ENST00000578925IKZF3chr1737985640-SRCIN1chr1736735044-0.0038010120.99619895
ENST00000377944ENST00000264659IKZF3chr1737985640-SRCIN1chr1736735044-0.0006171430.99938285
ENST00000377944ENST00000578925IKZF3chr1737985640-SRCIN1chr1736735044-0.0038010120.99619895
ENST00000377945ENST00000264659IKZF3chr1737985640-SRCIN1chr1736735044-0.0006171430.99938285
ENST00000377945ENST00000578925IKZF3chr1737985640-SRCIN1chr1736735044-0.0038010120.99619895
ENST00000377952ENST00000264659IKZF3chr1737985640-SRCIN1chr1736735044-0.0006171430.99938285
ENST00000377952ENST00000578925IKZF3chr1737985640-SRCIN1chr1736735044-0.0038010120.99619895
ENST00000377958ENST00000264659IKZF3chr1737985640-SRCIN1chr1736735044-0.0006171430.99938285
ENST00000377958ENST00000578925IKZF3chr1737985640-SRCIN1chr1736735044-0.0038010120.99619895
ENST00000346243ENST00000264659IKZF3chr1737985640-SRCIN1chr1736735044-0.0005445880.9994554
ENST00000346243ENST00000578925IKZF3chr1737985640-SRCIN1chr1736735044-0.0032804410.99671954
ENST00000350532ENST00000264659IKZF3chr1737985640-SRCIN1chr1736735044-0.0005445880.9994554
ENST00000350532ENST00000578925IKZF3chr1737985640-SRCIN1chr1736735044-0.0032804410.99671954
ENST00000351680ENST00000264659IKZF3chr1737985640-SRCIN1chr1736735044-0.0005445880.9994554
ENST00000351680ENST00000578925IKZF3chr1737985640-SRCIN1chr1736735044-0.0032804410.99671954
ENST00000467757ENST00000264659IKZF3chr1737985640-SRCIN1chr1736735044-0.0005445880.9994554
ENST00000467757ENST00000578925IKZF3chr1737985640-SRCIN1chr1736735044-0.0032804410.99671954
ENST00000439016ENST00000264659IKZF3chr1737985640-SRCIN1chr1736735044-0.0005462880.9994537
ENST00000439016ENST00000578925IKZF3chr1737985640-SRCIN1chr1736735044-0.0032990040.99670094

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>39410_39410_1_IKZF3-SRCIN1_IKZF3_chr17_37985640_ENST00000346243_SRCIN1_chr17_36735044_ENST00000264659_length(amino acids)=1230AA_BP=2
MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRR
FSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQPNYWSFKTRSSRHTQGAQPGLADQA
AKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGML
KSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPAPHLASGSPPPGLP
SGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAILERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLL
HEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGGPLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHS
PYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPGERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGL
VQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGGRSSGATPVSGPPPPSASSTPAGQPTAVSRLQMQLHLRGLQNSASDLRGQLQQLRK
LQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKA
LVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVTDTLAQIRRQVDEGVWPPPNNLLSQSPKKVTAETD
FNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAELLK
AIPDLDCASKAHPGPAPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKK
DSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAELESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSK

--------------------------------------------------------------

>39410_39410_2_IKZF3-SRCIN1_IKZF3_chr17_37985640_ENST00000346243_SRCIN1_chr17_36735044_ENST00000578925_length(amino acids)=1264AA_BP=2
MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRR
FSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQVGGWTVDPVCLLSSLCSHLHGDSAP
SGAGQPAQQPNYWSFKTRSSRHTQGAQPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGE
ETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRR
EMVYASRESSPTRRLNNLSPAPHLASGSPPPGLPSGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAIL
ERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGG
PLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPGE
RSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGGRSSGATPVSGPPPPSASSTPA
GQPTAVSRLQMQLHLRGLQNSASDLRGQLQQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELI
TQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVT
DTLAQIRRQVDEGVWPPPNNLLSQSPKKVTAETDFNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSVE
AAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKAHPGPAPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEK
PSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAEL
ESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSKHGKQRAEYMRIQAQQQATKPSKEMSGSNETSSPVSEKPSASRTSIPVLTSFGARNS

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>39410_39410_3_IKZF3-SRCIN1_IKZF3_chr17_37985640_ENST00000346872_SRCIN1_chr17_36735044_ENST00000264659_length(amino acids)=1230AA_BP=2
MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRR
FSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQPNYWSFKTRSSRHTQGAQPGLADQA
AKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGML
KSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPAPHLASGSPPPGLP
SGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAILERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLL
HEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGGPLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHS
PYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPGERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGL
VQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGGRSSGATPVSGPPPPSASSTPAGQPTAVSRLQMQLHLRGLQNSASDLRGQLQQLRK
LQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKA
LVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVTDTLAQIRRQVDEGVWPPPNNLLSQSPKKVTAETD
FNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAELLK
AIPDLDCASKAHPGPAPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKK
DSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAELESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSK

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>39410_39410_4_IKZF3-SRCIN1_IKZF3_chr17_37985640_ENST00000346872_SRCIN1_chr17_36735044_ENST00000578925_length(amino acids)=1264AA_BP=2
MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRR
FSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQVGGWTVDPVCLLSSLCSHLHGDSAP
SGAGQPAQQPNYWSFKTRSSRHTQGAQPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGE
ETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRR
EMVYASRESSPTRRLNNLSPAPHLASGSPPPGLPSGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAIL
ERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGG
PLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPGE
RSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGGRSSGATPVSGPPPPSASSTPA
GQPTAVSRLQMQLHLRGLQNSASDLRGQLQQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELI
TQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVT
DTLAQIRRQVDEGVWPPPNNLLSQSPKKVTAETDFNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSVE
AAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKAHPGPAPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEK
PSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAEL
ESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSKHGKQRAEYMRIQAQQQATKPSKEMSGSNETSSPVSEKPSASRTSIPVLTSFGARNS

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>39410_39410_5_IKZF3-SRCIN1_IKZF3_chr17_37985640_ENST00000350532_SRCIN1_chr17_36735044_ENST00000264659_length(amino acids)=1230AA_BP=2
MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRR
FSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQPNYWSFKTRSSRHTQGAQPGLADQA
AKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGML
KSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPAPHLASGSPPPGLP
SGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAILERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLL
HEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGGPLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHS
PYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPGERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGL
VQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGGRSSGATPVSGPPPPSASSTPAGQPTAVSRLQMQLHLRGLQNSASDLRGQLQQLRK
LQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKA
LVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVTDTLAQIRRQVDEGVWPPPNNLLSQSPKKVTAETD
FNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAELLK
AIPDLDCASKAHPGPAPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKK
DSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAELESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSK

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>39410_39410_6_IKZF3-SRCIN1_IKZF3_chr17_37985640_ENST00000350532_SRCIN1_chr17_36735044_ENST00000578925_length(amino acids)=1264AA_BP=2
MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRR
FSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQVGGWTVDPVCLLSSLCSHLHGDSAP
SGAGQPAQQPNYWSFKTRSSRHTQGAQPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGE
ETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRR
EMVYASRESSPTRRLNNLSPAPHLASGSPPPGLPSGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAIL
ERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGG
PLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPGE
RSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGGRSSGATPVSGPPPPSASSTPA
GQPTAVSRLQMQLHLRGLQNSASDLRGQLQQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELI
TQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVT
DTLAQIRRQVDEGVWPPPNNLLSQSPKKVTAETDFNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSVE
AAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKAHPGPAPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEK
PSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAEL
ESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSKHGKQRAEYMRIQAQQQATKPSKEMSGSNETSSPVSEKPSASRTSIPVLTSFGARNS

--------------------------------------------------------------

>39410_39410_7_IKZF3-SRCIN1_IKZF3_chr17_37985640_ENST00000351680_SRCIN1_chr17_36735044_ENST00000264659_length(amino acids)=1230AA_BP=2
MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRR
FSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQPNYWSFKTRSSRHTQGAQPGLADQA
AKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGML
KSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPAPHLASGSPPPGLP
SGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAILERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLL
HEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGGPLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHS
PYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPGERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGL
VQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGGRSSGATPVSGPPPPSASSTPAGQPTAVSRLQMQLHLRGLQNSASDLRGQLQQLRK
LQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKA
LVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVTDTLAQIRRQVDEGVWPPPNNLLSQSPKKVTAETD
FNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAELLK
AIPDLDCASKAHPGPAPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKK
DSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAELESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSK

--------------------------------------------------------------

>39410_39410_8_IKZF3-SRCIN1_IKZF3_chr17_37985640_ENST00000351680_SRCIN1_chr17_36735044_ENST00000578925_length(amino acids)=1264AA_BP=2
MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRR
FSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQVGGWTVDPVCLLSSLCSHLHGDSAP
SGAGQPAQQPNYWSFKTRSSRHTQGAQPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGE
ETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRR
EMVYASRESSPTRRLNNLSPAPHLASGSPPPGLPSGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAIL
ERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGG
PLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPGE
RSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGGRSSGATPVSGPPPPSASSTPA
GQPTAVSRLQMQLHLRGLQNSASDLRGQLQQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELI
TQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVT
DTLAQIRRQVDEGVWPPPNNLLSQSPKKVTAETDFNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSVE
AAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKAHPGPAPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEK
PSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAEL
ESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSKHGKQRAEYMRIQAQQQATKPSKEMSGSNETSSPVSEKPSASRTSIPVLTSFGARNS

--------------------------------------------------------------

>39410_39410_9_IKZF3-SRCIN1_IKZF3_chr17_37985640_ENST00000377944_SRCIN1_chr17_36735044_ENST00000264659_length(amino acids)=1230AA_BP=2
MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRR
FSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQPNYWSFKTRSSRHTQGAQPGLADQA
AKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGML
KSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPAPHLASGSPPPGLP
SGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAILERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLL
HEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGGPLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHS
PYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPGERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGL
VQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGGRSSGATPVSGPPPPSASSTPAGQPTAVSRLQMQLHLRGLQNSASDLRGQLQQLRK
LQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKA
LVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVTDTLAQIRRQVDEGVWPPPNNLLSQSPKKVTAETD
FNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAELLK
AIPDLDCASKAHPGPAPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKK
DSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAELESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSK

--------------------------------------------------------------

>39410_39410_10_IKZF3-SRCIN1_IKZF3_chr17_37985640_ENST00000377944_SRCIN1_chr17_36735044_ENST00000578925_length(amino acids)=1264AA_BP=2
MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRR
FSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQVGGWTVDPVCLLSSLCSHLHGDSAP
SGAGQPAQQPNYWSFKTRSSRHTQGAQPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGE
ETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRR
EMVYASRESSPTRRLNNLSPAPHLASGSPPPGLPSGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAIL
ERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGG
PLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPGE
RSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGGRSSGATPVSGPPPPSASSTPA
GQPTAVSRLQMQLHLRGLQNSASDLRGQLQQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELI
TQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVT
DTLAQIRRQVDEGVWPPPNNLLSQSPKKVTAETDFNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSVE
AAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKAHPGPAPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEK
PSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAEL
ESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSKHGKQRAEYMRIQAQQQATKPSKEMSGSNETSSPVSEKPSASRTSIPVLTSFGARNS

--------------------------------------------------------------

>39410_39410_11_IKZF3-SRCIN1_IKZF3_chr17_37985640_ENST00000377945_SRCIN1_chr17_36735044_ENST00000264659_length(amino acids)=1230AA_BP=2
MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRR
FSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQPNYWSFKTRSSRHTQGAQPGLADQA
AKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGML
KSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPAPHLASGSPPPGLP
SGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAILERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLL
HEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGGPLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHS
PYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPGERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGL
VQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGGRSSGATPVSGPPPPSASSTPAGQPTAVSRLQMQLHLRGLQNSASDLRGQLQQLRK
LQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKA
LVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVTDTLAQIRRQVDEGVWPPPNNLLSQSPKKVTAETD
FNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAELLK
AIPDLDCASKAHPGPAPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKK
DSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAELESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSK

--------------------------------------------------------------

>39410_39410_12_IKZF3-SRCIN1_IKZF3_chr17_37985640_ENST00000377945_SRCIN1_chr17_36735044_ENST00000578925_length(amino acids)=1264AA_BP=2
MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRR
FSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQVGGWTVDPVCLLSSLCSHLHGDSAP
SGAGQPAQQPNYWSFKTRSSRHTQGAQPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGE
ETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRR
EMVYASRESSPTRRLNNLSPAPHLASGSPPPGLPSGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAIL
ERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGG
PLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPGE
RSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGGRSSGATPVSGPPPPSASSTPA
GQPTAVSRLQMQLHLRGLQNSASDLRGQLQQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELI
TQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVT
DTLAQIRRQVDEGVWPPPNNLLSQSPKKVTAETDFNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSVE
AAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKAHPGPAPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEK
PSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAEL
ESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSKHGKQRAEYMRIQAQQQATKPSKEMSGSNETSSPVSEKPSASRTSIPVLTSFGARNS

--------------------------------------------------------------

>39410_39410_13_IKZF3-SRCIN1_IKZF3_chr17_37985640_ENST00000377952_SRCIN1_chr17_36735044_ENST00000264659_length(amino acids)=1230AA_BP=2
MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRR
FSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQPNYWSFKTRSSRHTQGAQPGLADQA
AKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGML
KSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPAPHLASGSPPPGLP
SGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAILERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLL
HEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGGPLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHS
PYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPGERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGL
VQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGGRSSGATPVSGPPPPSASSTPAGQPTAVSRLQMQLHLRGLQNSASDLRGQLQQLRK
LQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKA
LVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVTDTLAQIRRQVDEGVWPPPNNLLSQSPKKVTAETD
FNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAELLK
AIPDLDCASKAHPGPAPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKK
DSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAELESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSK

--------------------------------------------------------------

>39410_39410_14_IKZF3-SRCIN1_IKZF3_chr17_37985640_ENST00000377952_SRCIN1_chr17_36735044_ENST00000578925_length(amino acids)=1264AA_BP=2
MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRR
FSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQVGGWTVDPVCLLSSLCSHLHGDSAP
SGAGQPAQQPNYWSFKTRSSRHTQGAQPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGE
ETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRR
EMVYASRESSPTRRLNNLSPAPHLASGSPPPGLPSGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAIL
ERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGG
PLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPGE
RSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGGRSSGATPVSGPPPPSASSTPA
GQPTAVSRLQMQLHLRGLQNSASDLRGQLQQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELI
TQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVT
DTLAQIRRQVDEGVWPPPNNLLSQSPKKVTAETDFNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSVE
AAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKAHPGPAPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEK
PSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAEL
ESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSKHGKQRAEYMRIQAQQQATKPSKEMSGSNETSSPVSEKPSASRTSIPVLTSFGARNS

--------------------------------------------------------------

>39410_39410_15_IKZF3-SRCIN1_IKZF3_chr17_37985640_ENST00000377958_SRCIN1_chr17_36735044_ENST00000264659_length(amino acids)=1230AA_BP=2
MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRR
FSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQPNYWSFKTRSSRHTQGAQPGLADQA
AKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGML
KSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPAPHLASGSPPPGLP
SGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAILERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLL
HEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGGPLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHS
PYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPGERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGL
VQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGGRSSGATPVSGPPPPSASSTPAGQPTAVSRLQMQLHLRGLQNSASDLRGQLQQLRK
LQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKA
LVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVTDTLAQIRRQVDEGVWPPPNNLLSQSPKKVTAETD
FNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAELLK
AIPDLDCASKAHPGPAPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKK
DSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAELESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSK

--------------------------------------------------------------

>39410_39410_16_IKZF3-SRCIN1_IKZF3_chr17_37985640_ENST00000377958_SRCIN1_chr17_36735044_ENST00000578925_length(amino acids)=1264AA_BP=2
MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRR
FSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQVGGWTVDPVCLLSSLCSHLHGDSAP
SGAGQPAQQPNYWSFKTRSSRHTQGAQPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGE
ETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRR
EMVYASRESSPTRRLNNLSPAPHLASGSPPPGLPSGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAIL
ERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGG
PLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPGE
RSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGGRSSGATPVSGPPPPSASSTPA
GQPTAVSRLQMQLHLRGLQNSASDLRGQLQQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELI
TQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVT
DTLAQIRRQVDEGVWPPPNNLLSQSPKKVTAETDFNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSVE
AAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKAHPGPAPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEK
PSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAEL
ESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSKHGKQRAEYMRIQAQQQATKPSKEMSGSNETSSPVSEKPSASRTSIPVLTSFGARNS

--------------------------------------------------------------

>39410_39410_17_IKZF3-SRCIN1_IKZF3_chr17_37985640_ENST00000394189_SRCIN1_chr17_36735044_ENST00000264659_length(amino acids)=1230AA_BP=2
MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRR
FSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQPNYWSFKTRSSRHTQGAQPGLADQA
AKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGML
KSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPAPHLASGSPPPGLP
SGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAILERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLL
HEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGGPLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHS
PYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPGERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGL
VQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGGRSSGATPVSGPPPPSASSTPAGQPTAVSRLQMQLHLRGLQNSASDLRGQLQQLRK
LQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKA
LVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVTDTLAQIRRQVDEGVWPPPNNLLSQSPKKVTAETD
FNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAELLK
AIPDLDCASKAHPGPAPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKK
DSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAELESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSK

--------------------------------------------------------------

>39410_39410_18_IKZF3-SRCIN1_IKZF3_chr17_37985640_ENST00000394189_SRCIN1_chr17_36735044_ENST00000578925_length(amino acids)=1264AA_BP=2
MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRR
FSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQVGGWTVDPVCLLSSLCSHLHGDSAP
SGAGQPAQQPNYWSFKTRSSRHTQGAQPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGE
ETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRR
EMVYASRESSPTRRLNNLSPAPHLASGSPPPGLPSGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAIL
ERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGG
PLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPGE
RSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGGRSSGATPVSGPPPPSASSTPA
GQPTAVSRLQMQLHLRGLQNSASDLRGQLQQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELI
TQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVT
DTLAQIRRQVDEGVWPPPNNLLSQSPKKVTAETDFNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSVE
AAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKAHPGPAPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEK
PSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAEL
ESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSKHGKQRAEYMRIQAQQQATKPSKEMSGSNETSSPVSEKPSASRTSIPVLTSFGARNS

--------------------------------------------------------------

>39410_39410_19_IKZF3-SRCIN1_IKZF3_chr17_37985640_ENST00000439016_SRCIN1_chr17_36735044_ENST00000264659_length(amino acids)=1230AA_BP=2
MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRR
FSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQPNYWSFKTRSSRHTQGAQPGLADQA
AKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGML
KSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPAPHLASGSPPPGLP
SGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAILERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLL
HEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGGPLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHS
PYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPGERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGL
VQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGGRSSGATPVSGPPPPSASSTPAGQPTAVSRLQMQLHLRGLQNSASDLRGQLQQLRK
LQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKA
LVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVTDTLAQIRRQVDEGVWPPPNNLLSQSPKKVTAETD
FNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAELLK
AIPDLDCASKAHPGPAPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKK
DSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAELESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSK

--------------------------------------------------------------

>39410_39410_20_IKZF3-SRCIN1_IKZF3_chr17_37985640_ENST00000439016_SRCIN1_chr17_36735044_ENST00000578925_length(amino acids)=1264AA_BP=2
MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRR
FSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQVGGWTVDPVCLLSSLCSHLHGDSAP
SGAGQPAQQPNYWSFKTRSSRHTQGAQPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGE
ETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRR
EMVYASRESSPTRRLNNLSPAPHLASGSPPPGLPSGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAIL
ERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGG
PLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPGE
RSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGGRSSGATPVSGPPPPSASSTPA
GQPTAVSRLQMQLHLRGLQNSASDLRGQLQQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELI
TQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVT
DTLAQIRRQVDEGVWPPPNNLLSQSPKKVTAETDFNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSVE
AAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKAHPGPAPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEK
PSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAEL
ESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSKHGKQRAEYMRIQAQQQATKPSKEMSGSNETSSPVSEKPSASRTSIPVLTSFGARNS

--------------------------------------------------------------

>39410_39410_21_IKZF3-SRCIN1_IKZF3_chr17_37985640_ENST00000467757_SRCIN1_chr17_36735044_ENST00000264659_length(amino acids)=1230AA_BP=2
MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRR
FSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQPNYWSFKTRSSRHTQGAQPGLADQA
AKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGML
KSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPAPHLASGSPPPGLP
SGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAILERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLL
HEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGGPLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHS
PYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPGERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGL
VQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGGRSSGATPVSGPPPPSASSTPAGQPTAVSRLQMQLHLRGLQNSASDLRGQLQQLRK
LQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKA
LVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVTDTLAQIRRQVDEGVWPPPNNLLSQSPKKVTAETD
FNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAELLK
AIPDLDCASKAHPGPAPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKK
DSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAELESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSK

--------------------------------------------------------------

>39410_39410_22_IKZF3-SRCIN1_IKZF3_chr17_37985640_ENST00000467757_SRCIN1_chr17_36735044_ENST00000578925_length(amino acids)=1264AA_BP=2
MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRR
FSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQVGGWTVDPVCLLSSLCSHLHGDSAP
SGAGQPAQQPNYWSFKTRSSRHTQGAQPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGE
ETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRR
EMVYASRESSPTRRLNNLSPAPHLASGSPPPGLPSGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAIL
ERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGG
PLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPGE
RSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGGRSSGATPVSGPPPPSASSTPA
GQPTAVSRLQMQLHLRGLQNSASDLRGQLQQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELI
TQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVT
DTLAQIRRQVDEGVWPPPNNLLSQSPKKVTAETDFNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSVE
AAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKAHPGPAPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEK
PSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAEL
ESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSKHGKQRAEYMRIQAQQQATKPSKEMSGSNETSSPVSEKPSASRTSIPVLTSFGARNS

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:37985640/chr17:36752382)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IKZF3

Q9UKT9

.
FUNCTION: Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. {ECO:0000269|PubMed:10369681}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSRCIN1chr17:37985640chr17:36735044ENST00000264659019654_6747.3333333333333331184.0Coiled coilOntology_term=ECO:0000255
TgeneSRCIN1chr17:37985640chr17:36735044ENST00000264659019726_7467.3333333333333331184.0Coiled coilOntology_term=ECO:0000255
TgeneSRCIN1chr17:37985640chr17:36735044ENST00000264659019471_5047.3333333333333331184.0Compositional biasNote=Pro-rich
TgeneSRCIN1chr17:37985640chr17:36735044ENST00000264659019956_10147.3333333333333331184.0Compositional biasNote=Pro-rich

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIKZF3chr17:37985640chr17:36735044ENST00000346243-36118_14054.333333333333336432.0Zinc fingerC2H2-type 1
HgeneIKZF3chr17:37985640chr17:36735044ENST00000346243-36146_16854.333333333333336432.0Zinc fingerC2H2-type 2
HgeneIKZF3chr17:37985640chr17:36735044ENST00000346243-36174_19654.333333333333336432.0Zinc fingerC2H2-type 3
HgeneIKZF3chr17:37985640chr17:36735044ENST00000346243-36202_22454.333333333333336432.0Zinc fingerC2H2-type 4%3B atypical
HgeneIKZF3chr17:37985640chr17:36735044ENST00000346243-36452_47454.333333333333336432.0Zinc fingerC2H2-type 5
HgeneIKZF3chr17:37985640chr17:36735044ENST00000346243-36480_50454.333333333333336432.0Zinc fingerC2H2-type 6%3B atypical
HgeneIKZF3chr17:37985640chr17:36735044ENST00000346872-38118_14054.333333333333336510.0Zinc fingerC2H2-type 1
HgeneIKZF3chr17:37985640chr17:36735044ENST00000346872-38146_16854.333333333333336510.0Zinc fingerC2H2-type 2
HgeneIKZF3chr17:37985640chr17:36735044ENST00000346872-38174_19654.333333333333336510.0Zinc fingerC2H2-type 3
HgeneIKZF3chr17:37985640chr17:36735044ENST00000346872-38202_22454.333333333333336510.0Zinc fingerC2H2-type 4%3B atypical
HgeneIKZF3chr17:37985640chr17:36735044ENST00000346872-38452_47454.333333333333336510.0Zinc fingerC2H2-type 5
HgeneIKZF3chr17:37985640chr17:36735044ENST00000346872-38480_50454.333333333333336510.0Zinc fingerC2H2-type 6%3B atypical
HgeneIKZF3chr17:37985640chr17:36735044ENST00000350532-37118_14054.333333333333336471.0Zinc fingerC2H2-type 1
HgeneIKZF3chr17:37985640chr17:36735044ENST00000350532-37146_16854.333333333333336471.0Zinc fingerC2H2-type 2
HgeneIKZF3chr17:37985640chr17:36735044ENST00000350532-37174_19654.333333333333336471.0Zinc fingerC2H2-type 3
HgeneIKZF3chr17:37985640chr17:36735044ENST00000350532-37202_22454.333333333333336471.0Zinc fingerC2H2-type 4%3B atypical
HgeneIKZF3chr17:37985640chr17:36735044ENST00000350532-37452_47454.333333333333336471.0Zinc fingerC2H2-type 5
HgeneIKZF3chr17:37985640chr17:36735044ENST00000350532-37480_50454.333333333333336471.0Zinc fingerC2H2-type 6%3B atypical
HgeneIKZF3chr17:37985640chr17:36735044ENST00000351680-37118_14054.333333333333336471.0Zinc fingerC2H2-type 1
HgeneIKZF3chr17:37985640chr17:36735044ENST00000351680-37146_16854.333333333333336471.0Zinc fingerC2H2-type 2
HgeneIKZF3chr17:37985640chr17:36735044ENST00000351680-37174_19654.333333333333336471.0Zinc fingerC2H2-type 3
HgeneIKZF3chr17:37985640chr17:36735044ENST00000351680-37202_22454.333333333333336471.0Zinc fingerC2H2-type 4%3B atypical
HgeneIKZF3chr17:37985640chr17:36735044ENST00000351680-37452_47454.333333333333336471.0Zinc fingerC2H2-type 5
HgeneIKZF3chr17:37985640chr17:36735044ENST00000351680-37480_50454.333333333333336471.0Zinc fingerC2H2-type 6%3B atypical
HgeneIKZF3chr17:37985640chr17:36735044ENST00000377944-36118_14054.333333333333336367.0Zinc fingerC2H2-type 1
HgeneIKZF3chr17:37985640chr17:36735044ENST00000377944-36146_16854.333333333333336367.0Zinc fingerC2H2-type 2
HgeneIKZF3chr17:37985640chr17:36735044ENST00000377944-36174_19654.333333333333336367.0Zinc fingerC2H2-type 3
HgeneIKZF3chr17:37985640chr17:36735044ENST00000377944-36202_22454.333333333333336367.0Zinc fingerC2H2-type 4%3B atypical
HgeneIKZF3chr17:37985640chr17:36735044ENST00000377944-36452_47454.333333333333336367.0Zinc fingerC2H2-type 5
HgeneIKZF3chr17:37985640chr17:36735044ENST00000377944-36480_50454.333333333333336367.0Zinc fingerC2H2-type 6%3B atypical
HgeneIKZF3chr17:37985640chr17:36735044ENST00000377945-35118_14054.333333333333336376.0Zinc fingerC2H2-type 1
HgeneIKZF3chr17:37985640chr17:36735044ENST00000377945-35146_16854.333333333333336376.0Zinc fingerC2H2-type 2
HgeneIKZF3chr17:37985640chr17:36735044ENST00000377945-35174_19654.333333333333336376.0Zinc fingerC2H2-type 3
HgeneIKZF3chr17:37985640chr17:36735044ENST00000377945-35202_22454.333333333333336376.0Zinc fingerC2H2-type 4%3B atypical
HgeneIKZF3chr17:37985640chr17:36735044ENST00000377945-35452_47454.333333333333336376.0Zinc fingerC2H2-type 5
HgeneIKZF3chr17:37985640chr17:36735044ENST00000377945-35480_50454.333333333333336376.0Zinc fingerC2H2-type 6%3B atypical
HgeneIKZF3chr17:37985640chr17:36735044ENST00000377952-34118_14054.333333333333336289.0Zinc fingerC2H2-type 1
HgeneIKZF3chr17:37985640chr17:36735044ENST00000377952-34146_16854.333333333333336289.0Zinc fingerC2H2-type 2
HgeneIKZF3chr17:37985640chr17:36735044ENST00000377952-34174_19654.333333333333336289.0Zinc fingerC2H2-type 3
HgeneIKZF3chr17:37985640chr17:36735044ENST00000377952-34202_22454.333333333333336289.0Zinc fingerC2H2-type 4%3B atypical
HgeneIKZF3chr17:37985640chr17:36735044ENST00000377952-34452_47454.333333333333336289.0Zinc fingerC2H2-type 5
HgeneIKZF3chr17:37985640chr17:36735044ENST00000377952-34480_50454.333333333333336289.0Zinc fingerC2H2-type 6%3B atypical
HgeneIKZF3chr17:37985640chr17:36735044ENST00000377958-37118_14054.333333333333336423.0Zinc fingerC2H2-type 1
HgeneIKZF3chr17:37985640chr17:36735044ENST00000377958-37146_16854.333333333333336423.0Zinc fingerC2H2-type 2
HgeneIKZF3chr17:37985640chr17:36735044ENST00000377958-37174_19654.333333333333336423.0Zinc fingerC2H2-type 3
HgeneIKZF3chr17:37985640chr17:36735044ENST00000377958-37202_22454.333333333333336423.0Zinc fingerC2H2-type 4%3B atypical
HgeneIKZF3chr17:37985640chr17:36735044ENST00000377958-37452_47454.333333333333336423.0Zinc fingerC2H2-type 5
HgeneIKZF3chr17:37985640chr17:36735044ENST00000377958-37480_50454.333333333333336423.0Zinc fingerC2H2-type 6%3B atypical
HgeneIKZF3chr17:37985640chr17:36735044ENST00000394189-35118_14054.333333333333336328.0Zinc fingerC2H2-type 1
HgeneIKZF3chr17:37985640chr17:36735044ENST00000394189-35146_16854.333333333333336328.0Zinc fingerC2H2-type 2
HgeneIKZF3chr17:37985640chr17:36735044ENST00000394189-35174_19654.333333333333336328.0Zinc fingerC2H2-type 3
HgeneIKZF3chr17:37985640chr17:36735044ENST00000394189-35202_22454.333333333333336328.0Zinc fingerC2H2-type 4%3B atypical
HgeneIKZF3chr17:37985640chr17:36735044ENST00000394189-35452_47454.333333333333336328.0Zinc fingerC2H2-type 5
HgeneIKZF3chr17:37985640chr17:36735044ENST00000394189-35480_50454.333333333333336328.0Zinc fingerC2H2-type 6%3B atypical
HgeneIKZF3chr17:37985640chr17:36735044ENST00000439016-36118_14054.333333333333336415.0Zinc fingerC2H2-type 1
HgeneIKZF3chr17:37985640chr17:36735044ENST00000439016-36146_16854.333333333333336415.0Zinc fingerC2H2-type 2
HgeneIKZF3chr17:37985640chr17:36735044ENST00000439016-36174_19654.333333333333336415.0Zinc fingerC2H2-type 3
HgeneIKZF3chr17:37985640chr17:36735044ENST00000439016-36202_22454.333333333333336415.0Zinc fingerC2H2-type 4%3B atypical
HgeneIKZF3chr17:37985640chr17:36735044ENST00000439016-36452_47454.333333333333336415.0Zinc fingerC2H2-type 5
HgeneIKZF3chr17:37985640chr17:36735044ENST00000439016-36480_50454.333333333333336415.0Zinc fingerC2H2-type 6%3B atypical
HgeneIKZF3chr17:37985640chr17:36735044ENST00000439167-16118_1400437.0Zinc fingerC2H2-type 1
HgeneIKZF3chr17:37985640chr17:36735044ENST00000439167-16146_1680437.0Zinc fingerC2H2-type 2
HgeneIKZF3chr17:37985640chr17:36735044ENST00000439167-16174_1960437.0Zinc fingerC2H2-type 3
HgeneIKZF3chr17:37985640chr17:36735044ENST00000439167-16202_2240437.0Zinc fingerC2H2-type 4%3B atypical
HgeneIKZF3chr17:37985640chr17:36735044ENST00000439167-16452_4740437.0Zinc fingerC2H2-type 5
HgeneIKZF3chr17:37985640chr17:36735044ENST00000439167-16480_5040437.0Zinc fingerC2H2-type 6%3B atypical
HgeneIKZF3chr17:37985640chr17:36735044ENST00000467757-37118_14054.333333333333336454.0Zinc fingerC2H2-type 1
HgeneIKZF3chr17:37985640chr17:36735044ENST00000467757-37146_16854.333333333333336454.0Zinc fingerC2H2-type 2
HgeneIKZF3chr17:37985640chr17:36735044ENST00000467757-37174_19654.333333333333336454.0Zinc fingerC2H2-type 3
HgeneIKZF3chr17:37985640chr17:36735044ENST00000467757-37202_22454.333333333333336454.0Zinc fingerC2H2-type 4%3B atypical
HgeneIKZF3chr17:37985640chr17:36735044ENST00000467757-37452_47454.333333333333336454.0Zinc fingerC2H2-type 5
HgeneIKZF3chr17:37985640chr17:36735044ENST00000467757-37480_50454.333333333333336454.0Zinc fingerC2H2-type 6%3B atypical
HgeneIKZF3chr17:37985640chr17:36735044ENST00000535189-17118_1400476.0Zinc fingerC2H2-type 1
HgeneIKZF3chr17:37985640chr17:36735044ENST00000535189-17146_1680476.0Zinc fingerC2H2-type 2
HgeneIKZF3chr17:37985640chr17:36735044ENST00000535189-17174_1960476.0Zinc fingerC2H2-type 3
HgeneIKZF3chr17:37985640chr17:36735044ENST00000535189-17202_2240476.0Zinc fingerC2H2-type 4%3B atypical
HgeneIKZF3chr17:37985640chr17:36735044ENST00000535189-17452_4740476.0Zinc fingerC2H2-type 5
HgeneIKZF3chr17:37985640chr17:36735044ENST00000535189-17480_5040476.0Zinc fingerC2H2-type 6%3B atypical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
IKZF3
SRCIN1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to IKZF3-SRCIN1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to IKZF3-SRCIN1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource