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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ING5-UTRN

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ING5-UTRN
	FusionPDB ID: 39749
	FusionGDB2.0 ID: 39749
		Hgene	Tgene
	Gene symbol	ING5	UTRN
	Gene ID	84289	7402
	Gene name	inhibitor of growth family member 5	utrophin
	Synonyms	p28ING5	DMDL\|DRP\|DRP1
	Cytomap	2q37.3	6q24.2
	Type of gene	protein-coding	protein-coding
	Description	inhibitor of growth protein 5	utrophinDRP-1dystrophin-related protein 1
	Modification date	20200329	20200313
	UniProtAcc	Q8WYH8	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000482774, ENST00000313552, ENST00000406941,	ENST00000367526, ENST00000367545, ENST00000480333,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	2 X 2 X 2=8	41 X 16 X 12=7872
	# samples	2	42
	** MAII score	log2(2/8*10)=1.32192809488736	log2(42/7872*10)=-4.22826898767312 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ING5 [Title/Abstract] AND UTRN [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ING5(242651486)-UTRN(145148484), # samples:1
Anticipated loss of major functional domain due to fusion event.	ING5-UTRN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ING5-UTRN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ING5	GO:0006260	DNA replication	16387653
Hgene	ING5	GO:0006473	protein acetylation	12750254
Hgene	ING5	GO:0008285	negative regulation of cell proliferation	12750254
Hgene	ING5	GO:0043966	histone H3 acetylation	16387653
Hgene	ING5	GO:0045893	positive regulation of transcription, DNA-templated	16387653
Hgene	ING5	GO:0045926	negative regulation of growth	12750254

Fusion gene breakpoints across ING5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across UTRN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-GM-A2DN-01A	ING5	chr2	242651486	+	UTRN	chr6	145148484	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000313552

ING5

chr2

242651486

ENST00000367545

UTRN

chr6

145148484

3353

508

1315

429

ENST00000313552

ING5

chr2

242651486

ENST00000367526

UTRN

chr6

145148484

1322

508

1315

429

ENST00000406941

ING5

chr2

242651486

ENST00000367545

UTRN

chr6

145148484

3347

502

1309

429

ENST00000406941

ING5

chr2

242651486

ENST00000367526

UTRN

chr6

145148484

1316

502

1309

429

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000313552	ENST00000367545	ING5	chr2	242651486	+	UTRN	chr6	145148484	+	0.000469572	0.99953043
ENST00000313552	ENST00000367526	ING5	chr2	242651486	+	UTRN	chr6	145148484	+	0.004552317	0.9954477
ENST00000406941	ENST00000367545	ING5	chr2	242651486	+	UTRN	chr6	145148484	+	0.000469012	0.99953103
ENST00000406941	ENST00000367526	ING5	chr2	242651486	+	UTRN	chr6	145148484	+	0.004197627	0.99580234

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>39749_39749_1_ING5-UTRN_ING5_chr2_242651486_ENST00000313552_UTRN_chr6_145148484_ENST00000367526_length(amino acids)=429AA_BP=161
MATAMYLEHYLDSIENLPCELQRNFQLMRELDQRTEDKKAEIDILAAEYISTVKTLSPDQRVERLQKIQNAYSKCKEYSDDKVQLAMQTY
EMVDKHIRRLDADLARFEADLKDKMEGSDFESSGGRGLKKGRGQKEKRGSRGRGRRTSEEDTPKKKKHKGGPITLISMWPEHYDPSQSPQ
LFHDDTHSRIEQYATRLAQMERTNGSFLTDSSSTTGSVEDEHALIQQYCQTLGGESPVSQPQSPAQILKSVEREERGELERIIADLEEEQ
RNLQVEYEQLKDQHLRRGLPVGSPPESIISPHHTSEDSELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPESDSRING

--------------------------------------------------------------

>39749_39749_2_ING5-UTRN_ING5_chr2_242651486_ENST00000313552_UTRN_chr6_145148484_ENST00000367545_length(amino acids)=429AA_BP=161
MATAMYLEHYLDSIENLPCELQRNFQLMRELDQRTEDKKAEIDILAAEYISTVKTLSPDQRVERLQKIQNAYSKCKEYSDDKVQLAMQTY
EMVDKHIRRLDADLARFEADLKDKMEGSDFESSGGRGLKKGRGQKEKRGSRGRGRRTSEEDTPKKKKHKGGPITLISMWPEHYDPSQSPQ
LFHDDTHSRIEQYATRLAQMERTNGSFLTDSSSTTGSVEDEHALIQQYCQTLGGESPVSQPQSPAQILKSVEREERGELERIIADLEEEQ
RNLQVEYEQLKDQHLRRGLPVGSPPESIISPHHTSEDSELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPESDSRING

--------------------------------------------------------------

>39749_39749_3_ING5-UTRN_ING5_chr2_242651486_ENST00000406941_UTRN_chr6_145148484_ENST00000367526_length(amino acids)=429AA_BP=161
MATAMYLEHYLDSIENLPCELQRNFQLMRELDQRTEDKKAEIDILAAEYISTVKTLSPDQRVERLQKIQNAYSKCKEYSDDKVQLAMQTY
EMVDKHIRRLDADLARFEADLKDKMEGSDFESSGGRGLKKGRGQKEKRGSRGRGRRTSEEDTPKKKKHKGGPITLISMWPEHYDPSQSPQ
LFHDDTHSRIEQYATRLAQMERTNGSFLTDSSSTTGSVEDEHALIQQYCQTLGGESPVSQPQSPAQILKSVEREERGELERIIADLEEEQ
RNLQVEYEQLKDQHLRRGLPVGSPPESIISPHHTSEDSELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPESDSRING

--------------------------------------------------------------

>39749_39749_4_ING5-UTRN_ING5_chr2_242651486_ENST00000406941_UTRN_chr6_145148484_ENST00000367545_length(amino acids)=429AA_BP=161
MATAMYLEHYLDSIENLPCELQRNFQLMRELDQRTEDKKAEIDILAAEYISTVKTLSPDQRVERLQKIQNAYSKCKEYSDDKVQLAMQTY
EMVDKHIRRLDADLARFEADLKDKMEGSDFESSGGRGLKKGRGQKEKRGSRGRGRRTSEEDTPKKKKHKGGPITLISMWPEHYDPSQSPQ
LFHDDTHSRIEQYATRLAQMERTNGSFLTDSSSTTGSVEDEHALIQQYCQTLGGESPVSQPQSPAQILKSVEREERGELERIIADLEEEQ
RNLQVEYEQLKDQHLRRGLPVGSPPESIISPHHTSEDSELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPESDSRING

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:242651486/chr6:145148484)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ING5 Q8WYH8	.
FUNCTION: Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4 (PubMed:24065767). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator (PubMed:12750254, PubMed:16387653). Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner (PubMed:21750715). {ECO:0000269\|PubMed:12750254, ECO:0000269\|PubMed:16387653, ECO:0000269\|PubMed:21750715, ECO:0000269\|PubMed:24065767}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ING5

chr2:242651486

chr6:145148484

ENST00000313552

186_235

160.66666666666666

241.0

Zinc finger

PHD-type

Hgene

ING5

chr2:242651486

chr6:145148484

ENST00000406941

186_235

160.66666666666666

227.0

Zinc finger

PHD-type

Tgene

UTRN

chr2:242651486

chr6:145148484

ENST00000367545

150_255

3164.6666666666665

3434.0

Domain

Calponin-homology (CH) 2

Tgene

UTRN

chr2:242651486

chr6:145148484

ENST00000367545

2812_2845

3164.6666666666665

3434.0

Domain

Tgene

UTRN

chr2:242651486

chr6:145148484

ENST00000367545

31_135

3164.6666666666665

3434.0

Domain

Calponin-homology (CH) 1

Tgene

UTRN

chr2:242651486

chr6:145148484

ENST00000367545

1_246

3164.6666666666665

3434.0

Region

Note=Actin-binding

Tgene

UTRN

chr2:242651486

chr6:145148484

ENST00000367545

1019_1121

3164.6666666666665

3434.0

Repeat

Spectrin 7

Tgene

UTRN

chr2:242651486

chr6:145148484

ENST00000367545

1128_1229

3164.6666666666665

3434.0

Repeat

Spectrin 8

Tgene

UTRN

chr2:242651486

chr6:145148484

ENST00000367545

1236_1333

3164.6666666666665

3434.0

Repeat

Spectrin 9

Tgene

UTRN

chr2:242651486

chr6:145148484

ENST00000367545

1335_1436

3164.6666666666665

3434.0

Repeat

Spectrin 10

Tgene

UTRN

chr2:242651486

chr6:145148484

ENST00000367545

1438_1540

3164.6666666666665

3434.0

Repeat

Spectrin 11

Tgene

UTRN

chr2:242651486

chr6:145148484

ENST00000367545

1547_1648

3164.6666666666665

3434.0

Repeat

Spectrin 12

Tgene

UTRN

chr2:242651486

chr6:145148484

ENST00000367545

1653_1747

3164.6666666666665

3434.0

Repeat

Spectrin 13

Tgene

UTRN

chr2:242651486

chr6:145148484

ENST00000367545

1748_1848

3164.6666666666665

3434.0

Repeat

Spectrin 14

Tgene

UTRN

chr2:242651486

chr6:145148484

ENST00000367545

1849_1968

3164.6666666666665

3434.0

Repeat

Spectrin 15

Tgene

UTRN

chr2:242651486

chr6:145148484

ENST00000367545

1979_2080

3164.6666666666665

3434.0

Repeat

Spectrin 16

Tgene

UTRN

chr2:242651486

chr6:145148484

ENST00000367545

2087_2186

3164.6666666666665

3434.0

Repeat

Spectrin 17

Tgene

UTRN

chr2:242651486

chr6:145148484

ENST00000367545

2229_2332

3164.6666666666665

3434.0

Repeat

Spectrin 18

Tgene

UTRN

chr2:242651486

chr6:145148484

ENST00000367545

2349_2439

3164.6666666666665

3434.0

Repeat

Spectrin 19

Tgene

UTRN

chr2:242651486

chr6:145148484

ENST00000367545

2446_2555

3164.6666666666665

3434.0

Repeat

Spectrin 20

Tgene

UTRN

chr2:242651486

chr6:145148484

ENST00000367545

2562_2687

3164.6666666666665

3434.0

Repeat

Spectrin 21

Tgene

UTRN

chr2:242651486

chr6:145148484

ENST00000367545

2694_2796

3164.6666666666665

3434.0

Repeat

Spectrin 22

Tgene

UTRN

chr2:242651486

chr6:145148484

ENST00000367545

312_416

3164.6666666666665

3434.0

Repeat

Spectrin 1

Tgene

UTRN

chr2:242651486

chr6:145148484

ENST00000367545

421_525

3164.6666666666665

3434.0

Repeat

Spectrin 2

Tgene

UTRN

chr2:242651486

chr6:145148484

ENST00000367545

532_636

3164.6666666666665

3434.0

Repeat

Spectrin 3

Tgene

UTRN

chr2:242651486

chr6:145148484

ENST00000367545

690_795

3164.6666666666665

3434.0

Repeat

Spectrin 4

Tgene

UTRN

chr2:242651486

chr6:145148484

ENST00000367545

801_901

3164.6666666666665

3434.0

Repeat

Spectrin 5

Tgene

UTRN

chr2:242651486

chr6:145148484

ENST00000367545

910_1012

3164.6666666666665

3434.0

Repeat

Spectrin 6

Tgene

UTRN

chr2:242651486

chr6:145148484

ENST00000367545

3064_3111

3164.6666666666665

3434.0

Zinc finger

ZZ-type

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ING5
UTRN

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	UTRN	chr2:242651486	chr6:145148484	ENST00000367545		64	74	1336_1768	3164.6666666666665	3434.0	SYNM
Tgene	UTRN	chr2:242651486	chr6:145148484	ENST00000367545		64	74	268_905	3164.6666666666665	3434.0	SYNM
Tgene	UTRN	chr2:242651486	chr6:145148484	ENST00000367545		64	74	2798_3165	3164.6666666666665	3434.0	SYNM

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Related Drugs to ING5-UTRN

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to ING5-UTRN

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source