UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:ITGB4-KRT18

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ITGB4-KRT18
FusionPDB ID: 40535
FusionGDB2.0 ID: 40535
HgeneTgene
Gene symbol

ITGB4

KRT18

Gene ID

3691

3875

Gene nameintegrin subunit beta 4keratin 18
SynonymsCD104|GP150CK-18|CYK18|K18
Cytomap

17q25.1

12q13.13

Type of geneprotein-codingprotein-coding
Descriptionintegrin beta-4CD104 antigenkeratin, type I cytoskeletal 18cell proliferation-inducing gene 46 proteincytokeratin 18keratin 18, type I
Modification date2020032920200327
UniProtAcc

P16144

P05783

Ensembl transtripts involved in fusion geneENST idsENST00000584558, ENST00000200181, 
ENST00000339591, ENST00000449880, 
ENST00000450894, ENST00000579662, 
ENST00000388835, ENST00000388837, 
ENST00000550600, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score23 X 19 X 10=43704 X 2 X 2=16
# samples 295
** MAII scorelog2(29/4370*10)=-3.91350847437303
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/16*10)=1.64385618977472
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ITGB4 [Title/Abstract] AND KRT18 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ITGB4(73732235)-KRT18(53345903), # samples:1
Anticipated loss of major functional domain due to fusion event.ITGB4-KRT18 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ITGB4-KRT18 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ITGB4-KRT18 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ITGB4-KRT18 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ITGB4-KRT18 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ITGB4-KRT18 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ITGB4-KRT18 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneITGB4

GO:0009611

response to wounding

19403692

HgeneITGB4

GO:0031581

hemidesmosome assembly

12482924

TgeneKRT18

GO:0043000

Golgi to plasma membrane CFTR protein transport

15529338

TgeneKRT18

GO:0043066

negative regulation of apoptotic process

11684708

TgeneKRT18

GO:0045104

intermediate filament cytoskeleton organization

20346438


check buttonFusion gene breakpoints across ITGB4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KRT18 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-G4-6293-01AITGB4chr17

73732235

+KRT18chr12

53345903

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000579662ITGB4chr1773732235+ENST00000388837KRT18chr1253345903+241020072462351701
ENST00000579662ITGB4chr1773732235+ENST00000388835KRT18chr1253345903+241120072462351701
ENST00000339591ITGB4chr1773732235+ENST00000388837KRT18chr1253345903+235119481632292709
ENST00000339591ITGB4chr1773732235+ENST00000388835KRT18chr1253345903+235219481632292709
ENST00000200181ITGB4chr1773732235+ENST00000388837KRT18chr1253345903+235119481632292709
ENST00000200181ITGB4chr1773732235+ENST00000388835KRT18chr1253345903+235219481632292709
ENST00000450894ITGB4chr1773732235+ENST00000388837KRT18chr1253345903+229018871022231709
ENST00000450894ITGB4chr1773732235+ENST00000388835KRT18chr1253345903+229118871022231709
ENST00000449880ITGB4chr1773732235+ENST00000388837KRT18chr1253345903+2172176982113701
ENST00000449880ITGB4chr1773732235+ENST00000388835KRT18chr1253345903+2173176982113701

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000579662ENST00000388837ITGB4chr1773732235+KRT18chr1253345903+0.0102308320.9897691
ENST00000579662ENST00000388835ITGB4chr1773732235+KRT18chr1253345903+0.0103530830.98964685
ENST00000339591ENST00000388837ITGB4chr1773732235+KRT18chr1253345903+0.011871610.98812836
ENST00000339591ENST00000388835ITGB4chr1773732235+KRT18chr1253345903+0.012003540.9879965
ENST00000200181ENST00000388837ITGB4chr1773732235+KRT18chr1253345903+0.011871610.98812836
ENST00000200181ENST00000388835ITGB4chr1773732235+KRT18chr1253345903+0.012003540.9879965
ENST00000450894ENST00000388837ITGB4chr1773732235+KRT18chr1253345903+0.0123892910.9876107
ENST00000450894ENST00000388835ITGB4chr1773732235+KRT18chr1253345903+0.0125112620.9874887
ENST00000449880ENST00000388837ITGB4chr1773732235+KRT18chr1253345903+0.012210290.98778975
ENST00000449880ENST00000388835ITGB4chr1773732235+KRT18chr1253345903+0.0123564820.9876436

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>40535_40535_1_ITGB4-KRT18_ITGB4_chr17_73732235_ENST00000200181_KRT18_chr12_53345903_ENST00000388835_length(amino acids)=709AA_BP=110
MAGRGRKRMAGPRPSPWARLLLAALISVSLSGTLANRCKKAPVKSCTECVRVDKDCAYCTDEMFRDRRCNTQAELLAAGCQRESIVVMES
SFQITEETQIDTTLRRSQMSPQGLRVRLRPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFG
KFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFS
TESAFHYEADGANVLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDS
SNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSKMFQKTRTGSFHIRRGEVGIYQVQLRALEHVDGTHVCQLPEDQKGNIHLKPSFSD
GLKMDAGIICDVCTCELQKEVRSARCSFNGDFVCGQCVCSEGWSGQTCNCSTGSLSDIQPCLREGEDKPCSGRGECQCGHCVCYGEGRYE
GQFCEYDNFQCPRTSGFLCNDRGRCSMGQCVCEPGWTGPSCDCPLSNATCIDSNGKASLENSLREVEARYALQMEQLNGILLHLESELAQ

--------------------------------------------------------------

>40535_40535_2_ITGB4-KRT18_ITGB4_chr17_73732235_ENST00000200181_KRT18_chr12_53345903_ENST00000388837_length(amino acids)=709AA_BP=110
MAGRGRKRMAGPRPSPWARLLLAALISVSLSGTLANRCKKAPVKSCTECVRVDKDCAYCTDEMFRDRRCNTQAELLAAGCQRESIVVMES
SFQITEETQIDTTLRRSQMSPQGLRVRLRPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFG
KFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFS
TESAFHYEADGANVLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDS
SNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSKMFQKTRTGSFHIRRGEVGIYQVQLRALEHVDGTHVCQLPEDQKGNIHLKPSFSD
GLKMDAGIICDVCTCELQKEVRSARCSFNGDFVCGQCVCSEGWSGQTCNCSTGSLSDIQPCLREGEDKPCSGRGECQCGHCVCYGEGRYE
GQFCEYDNFQCPRTSGFLCNDRGRCSMGQCVCEPGWTGPSCDCPLSNATCIDSNGKASLENSLREVEARYALQMEQLNGILLHLESELAQ

--------------------------------------------------------------

>40535_40535_3_ITGB4-KRT18_ITGB4_chr17_73732235_ENST00000339591_KRT18_chr12_53345903_ENST00000388835_length(amino acids)=709AA_BP=110
MAGRGRKRMAGPRPSPWARLLLAALISVSLSGTLANRCKKAPVKSCTECVRVDKDCAYCTDEMFRDRRCNTQAELLAAGCQRESIVVMES
SFQITEETQIDTTLRRSQMSPQGLRVRLRPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFG
KFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFS
TESAFHYEADGANVLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDS
SNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSKMFQKTRTGSFHIRRGEVGIYQVQLRALEHVDGTHVCQLPEDQKGNIHLKPSFSD
GLKMDAGIICDVCTCELQKEVRSARCSFNGDFVCGQCVCSEGWSGQTCNCSTGSLSDIQPCLREGEDKPCSGRGECQCGHCVCYGEGRYE
GQFCEYDNFQCPRTSGFLCNDRGRCSMGQCVCEPGWTGPSCDCPLSNATCIDSNGKASLENSLREVEARYALQMEQLNGILLHLESELAQ

--------------------------------------------------------------

>40535_40535_4_ITGB4-KRT18_ITGB4_chr17_73732235_ENST00000339591_KRT18_chr12_53345903_ENST00000388837_length(amino acids)=709AA_BP=110
MAGRGRKRMAGPRPSPWARLLLAALISVSLSGTLANRCKKAPVKSCTECVRVDKDCAYCTDEMFRDRRCNTQAELLAAGCQRESIVVMES
SFQITEETQIDTTLRRSQMSPQGLRVRLRPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFG
KFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFS
TESAFHYEADGANVLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDS
SNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSKMFQKTRTGSFHIRRGEVGIYQVQLRALEHVDGTHVCQLPEDQKGNIHLKPSFSD
GLKMDAGIICDVCTCELQKEVRSARCSFNGDFVCGQCVCSEGWSGQTCNCSTGSLSDIQPCLREGEDKPCSGRGECQCGHCVCYGEGRYE
GQFCEYDNFQCPRTSGFLCNDRGRCSMGQCVCEPGWTGPSCDCPLSNATCIDSNGKASLENSLREVEARYALQMEQLNGILLHLESELAQ

--------------------------------------------------------------

>40535_40535_5_ITGB4-KRT18_ITGB4_chr17_73732235_ENST00000449880_KRT18_chr12_53345903_ENST00000388835_length(amino acids)=701AA_BP=102
MAGPRPSPWARLLLAALISVSLSGTLANRCKKAPVKSCTECVRVDKDCAYCTDEMFRDRRCNTQAELLAAGCQRESIVVMESSFQITEET
QIDTTLRRSQMSPQGLRVRLRPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSV
PQTDMRPEKLKEPWPNSDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESAFHYE
ADGANVLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDSSNIVELLE
EAFNRIRSNLDIRALDSPRGLRTEVTSKMFQKTRTGSFHIRRGEVGIYQVQLRALEHVDGTHVCQLPEDQKGNIHLKPSFSDGLKMDAGI
ICDVCTCELQKEVRSARCSFNGDFVCGQCVCSEGWSGQTCNCSTGSLSDIQPCLREGEDKPCSGRGECQCGHCVCYGEGRYEGQFCEYDN
FQCPRTSGFLCNDRGRCSMGQCVCEPGWTGPSCDCPLSNATCIDSNGKASLENSLREVEARYALQMEQLNGILLHLESELAQTRAEGQRQ

--------------------------------------------------------------

>40535_40535_6_ITGB4-KRT18_ITGB4_chr17_73732235_ENST00000449880_KRT18_chr12_53345903_ENST00000388837_length(amino acids)=701AA_BP=102
MAGPRPSPWARLLLAALISVSLSGTLANRCKKAPVKSCTECVRVDKDCAYCTDEMFRDRRCNTQAELLAAGCQRESIVVMESSFQITEET
QIDTTLRRSQMSPQGLRVRLRPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSV
PQTDMRPEKLKEPWPNSDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESAFHYE
ADGANVLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDSSNIVELLE
EAFNRIRSNLDIRALDSPRGLRTEVTSKMFQKTRTGSFHIRRGEVGIYQVQLRALEHVDGTHVCQLPEDQKGNIHLKPSFSDGLKMDAGI
ICDVCTCELQKEVRSARCSFNGDFVCGQCVCSEGWSGQTCNCSTGSLSDIQPCLREGEDKPCSGRGECQCGHCVCYGEGRYEGQFCEYDN
FQCPRTSGFLCNDRGRCSMGQCVCEPGWTGPSCDCPLSNATCIDSNGKASLENSLREVEARYALQMEQLNGILLHLESELAQTRAEGQRQ

--------------------------------------------------------------

>40535_40535_7_ITGB4-KRT18_ITGB4_chr17_73732235_ENST00000450894_KRT18_chr12_53345903_ENST00000388835_length(amino acids)=709AA_BP=110
MAGRGRKRMAGPRPSPWARLLLAALISVSLSGTLANRCKKAPVKSCTECVRVDKDCAYCTDEMFRDRRCNTQAELLAAGCQRESIVVMES
SFQITEETQIDTTLRRSQMSPQGLRVRLRPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFG
KFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFS
TESAFHYEADGANVLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDS
SNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSKMFQKTRTGSFHIRRGEVGIYQVQLRALEHVDGTHVCQLPEDQKGNIHLKPSFSD
GLKMDAGIICDVCTCELQKEVRSARCSFNGDFVCGQCVCSEGWSGQTCNCSTGSLSDIQPCLREGEDKPCSGRGECQCGHCVCYGEGRYE
GQFCEYDNFQCPRTSGFLCNDRGRCSMGQCVCEPGWTGPSCDCPLSNATCIDSNGKASLENSLREVEARYALQMEQLNGILLHLESELAQ

--------------------------------------------------------------

>40535_40535_8_ITGB4-KRT18_ITGB4_chr17_73732235_ENST00000450894_KRT18_chr12_53345903_ENST00000388837_length(amino acids)=709AA_BP=110
MAGRGRKRMAGPRPSPWARLLLAALISVSLSGTLANRCKKAPVKSCTECVRVDKDCAYCTDEMFRDRRCNTQAELLAAGCQRESIVVMES
SFQITEETQIDTTLRRSQMSPQGLRVRLRPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFG
KFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFS
TESAFHYEADGANVLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDS
SNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSKMFQKTRTGSFHIRRGEVGIYQVQLRALEHVDGTHVCQLPEDQKGNIHLKPSFSD
GLKMDAGIICDVCTCELQKEVRSARCSFNGDFVCGQCVCSEGWSGQTCNCSTGSLSDIQPCLREGEDKPCSGRGECQCGHCVCYGEGRYE
GQFCEYDNFQCPRTSGFLCNDRGRCSMGQCVCEPGWTGPSCDCPLSNATCIDSNGKASLENSLREVEARYALQMEQLNGILLHLESELAQ

--------------------------------------------------------------

>40535_40535_9_ITGB4-KRT18_ITGB4_chr17_73732235_ENST00000579662_KRT18_chr12_53345903_ENST00000388835_length(amino acids)=701AA_BP=102
MAGPRPSPWARLLLAALISVSLSGTLANRCKKAPVKSCTECVRVDKDCAYCTDEMFRDRRCNTQAELLAAGCQRESIVVMESSFQITEET
QIDTTLRRSQMSPQGLRVRLRPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSV
PQTDMRPEKLKEPWPNSDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESAFHYE
ADGANVLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDSSNIVELLE
EAFNRIRSNLDIRALDSPRGLRTEVTSKMFQKTRTGSFHIRRGEVGIYQVQLRALEHVDGTHVCQLPEDQKGNIHLKPSFSDGLKMDAGI
ICDVCTCELQKEVRSARCSFNGDFVCGQCVCSEGWSGQTCNCSTGSLSDIQPCLREGEDKPCSGRGECQCGHCVCYGEGRYEGQFCEYDN
FQCPRTSGFLCNDRGRCSMGQCVCEPGWTGPSCDCPLSNATCIDSNGKASLENSLREVEARYALQMEQLNGILLHLESELAQTRAEGQRQ

--------------------------------------------------------------

>40535_40535_10_ITGB4-KRT18_ITGB4_chr17_73732235_ENST00000579662_KRT18_chr12_53345903_ENST00000388837_length(amino acids)=701AA_BP=102
MAGPRPSPWARLLLAALISVSLSGTLANRCKKAPVKSCTECVRVDKDCAYCTDEMFRDRRCNTQAELLAAGCQRESIVVMESSFQITEET
QIDTTLRRSQMSPQGLRVRLRPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSV
PQTDMRPEKLKEPWPNSDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESAFHYE
ADGANVLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDSSNIVELLE
EAFNRIRSNLDIRALDSPRGLRTEVTSKMFQKTRTGSFHIRRGEVGIYQVQLRALEHVDGTHVCQLPEDQKGNIHLKPSFSDGLKMDAGI
ICDVCTCELQKEVRSARCSFNGDFVCGQCVCSEGWSGQTCNCSTGSLSDIQPCLREGEDKPCSGRGECQCGHCVCYGEGRYEGQFCEYDN
FQCPRTSGFLCNDRGRCSMGQCVCEPGWTGPSCDCPLSNATCIDSNGKASLENSLREVEARYALQMEQLNGILLHLESELAQTRAEGQRQ

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:73732235/chr12:53345903)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ITGB4

P16144

KRT18

P05783

FUNCTION: Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}.FUNCTION: Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITGB4chr17:73732235chr12:53345903ENST00000200181+1440131_329587.01823.0DomainNote=VWFA
HgeneITGB4chr17:73732235chr12:53345903ENST00000200181+144029_73587.01823.0DomainNote=PSI
HgeneITGB4chr17:73732235chr12:53345903ENST00000339591+1440131_329587.01806.0DomainNote=VWFA
HgeneITGB4chr17:73732235chr12:53345903ENST00000339591+144029_73587.01806.0DomainNote=PSI
HgeneITGB4chr17:73732235chr12:53345903ENST00000449880+1339131_329587.01806.0DomainNote=VWFA
HgeneITGB4chr17:73732235chr12:53345903ENST00000449880+133929_73587.01806.0DomainNote=PSI
HgeneITGB4chr17:73732235chr12:53345903ENST00000450894+1439131_329587.01753.0DomainNote=VWFA
HgeneITGB4chr17:73732235chr12:53345903ENST00000450894+143929_73587.01753.0DomainNote=PSI
HgeneITGB4chr17:73732235chr12:53345903ENST00000579662+1439131_329587.01753.0DomainNote=VWFA
HgeneITGB4chr17:73732235chr12:53345903ENST00000579662+143929_73587.01753.0DomainNote=PSI
HgeneITGB4chr17:73732235chr12:53345903ENST00000200181+1440194_199587.01823.0RegionInvolved in NRG1- and IGF1-binding
HgeneITGB4chr17:73732235chr12:53345903ENST00000339591+1440194_199587.01806.0RegionInvolved in NRG1- and IGF1-binding
HgeneITGB4chr17:73732235chr12:53345903ENST00000449880+1339194_199587.01806.0RegionInvolved in NRG1- and IGF1-binding
HgeneITGB4chr17:73732235chr12:53345903ENST00000450894+1439194_199587.01753.0RegionInvolved in NRG1- and IGF1-binding
HgeneITGB4chr17:73732235chr12:53345903ENST00000579662+1439194_199587.01753.0RegionInvolved in NRG1- and IGF1-binding
HgeneITGB4chr17:73732235chr12:53345903ENST00000200181+1440456_502587.01823.0RepeatNote=I
HgeneITGB4chr17:73732235chr12:53345903ENST00000200181+1440503_542587.01823.0RepeatNote=II
HgeneITGB4chr17:73732235chr12:53345903ENST00000200181+1440543_581587.01823.0RepeatNote=III
HgeneITGB4chr17:73732235chr12:53345903ENST00000339591+1440456_502587.01806.0RepeatNote=I
HgeneITGB4chr17:73732235chr12:53345903ENST00000339591+1440503_542587.01806.0RepeatNote=II
HgeneITGB4chr17:73732235chr12:53345903ENST00000339591+1440543_581587.01806.0RepeatNote=III
HgeneITGB4chr17:73732235chr12:53345903ENST00000449880+1339456_502587.01806.0RepeatNote=I
HgeneITGB4chr17:73732235chr12:53345903ENST00000449880+1339503_542587.01806.0RepeatNote=II
HgeneITGB4chr17:73732235chr12:53345903ENST00000449880+1339543_581587.01806.0RepeatNote=III
HgeneITGB4chr17:73732235chr12:53345903ENST00000450894+1439456_502587.01753.0RepeatNote=I
HgeneITGB4chr17:73732235chr12:53345903ENST00000450894+1439503_542587.01753.0RepeatNote=II
HgeneITGB4chr17:73732235chr12:53345903ENST00000450894+1439543_581587.01753.0RepeatNote=III
HgeneITGB4chr17:73732235chr12:53345903ENST00000579662+1439456_502587.01753.0RepeatNote=I
HgeneITGB4chr17:73732235chr12:53345903ENST00000579662+1439503_542587.01753.0RepeatNote=II
HgeneITGB4chr17:73732235chr12:53345903ENST00000579662+1439543_581587.01753.0RepeatNote=III
TgeneKRT18chr17:73732235chr12:53345903ENST0000038883547388_430316.0431.0RegionNote=Tail
TgeneKRT18chr17:73732235chr12:53345903ENST0000038883758388_430316.0431.0RegionNote=Tail

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITGB4chr17:73732235chr12:53345903ENST00000200181+14401129_1218587.01823.0DomainFibronectin type-III 1
HgeneITGB4chr17:73732235chr12:53345903ENST00000200181+14401222_1321587.01823.0DomainFibronectin type-III 2
HgeneITGB4chr17:73732235chr12:53345903ENST00000200181+14401530_1625587.01823.0DomainFibronectin type-III 3
HgeneITGB4chr17:73732235chr12:53345903ENST00000200181+14401643_1739587.01823.0DomainFibronectin type-III 4
HgeneITGB4chr17:73732235chr12:53345903ENST00000200181+1440979_1084587.01823.0DomainNote=Calx-beta
HgeneITGB4chr17:73732235chr12:53345903ENST00000339591+14401129_1218587.01806.0DomainFibronectin type-III 1
HgeneITGB4chr17:73732235chr12:53345903ENST00000339591+14401222_1321587.01806.0DomainFibronectin type-III 2
HgeneITGB4chr17:73732235chr12:53345903ENST00000339591+14401530_1625587.01806.0DomainFibronectin type-III 3
HgeneITGB4chr17:73732235chr12:53345903ENST00000339591+14401643_1739587.01806.0DomainFibronectin type-III 4
HgeneITGB4chr17:73732235chr12:53345903ENST00000339591+1440979_1084587.01806.0DomainNote=Calx-beta
HgeneITGB4chr17:73732235chr12:53345903ENST00000449880+13391129_1218587.01806.0DomainFibronectin type-III 1
HgeneITGB4chr17:73732235chr12:53345903ENST00000449880+13391222_1321587.01806.0DomainFibronectin type-III 2
HgeneITGB4chr17:73732235chr12:53345903ENST00000449880+13391530_1625587.01806.0DomainFibronectin type-III 3
HgeneITGB4chr17:73732235chr12:53345903ENST00000449880+13391643_1739587.01806.0DomainFibronectin type-III 4
HgeneITGB4chr17:73732235chr12:53345903ENST00000449880+1339979_1084587.01806.0DomainNote=Calx-beta
HgeneITGB4chr17:73732235chr12:53345903ENST00000450894+14391129_1218587.01753.0DomainFibronectin type-III 1
HgeneITGB4chr17:73732235chr12:53345903ENST00000450894+14391222_1321587.01753.0DomainFibronectin type-III 2
HgeneITGB4chr17:73732235chr12:53345903ENST00000450894+14391530_1625587.01753.0DomainFibronectin type-III 3
HgeneITGB4chr17:73732235chr12:53345903ENST00000450894+14391643_1739587.01753.0DomainFibronectin type-III 4
HgeneITGB4chr17:73732235chr12:53345903ENST00000450894+1439979_1084587.01753.0DomainNote=Calx-beta
HgeneITGB4chr17:73732235chr12:53345903ENST00000579662+14391129_1218587.01753.0DomainFibronectin type-III 1
HgeneITGB4chr17:73732235chr12:53345903ENST00000579662+14391222_1321587.01753.0DomainFibronectin type-III 2
HgeneITGB4chr17:73732235chr12:53345903ENST00000579662+14391530_1625587.01753.0DomainFibronectin type-III 3
HgeneITGB4chr17:73732235chr12:53345903ENST00000579662+14391643_1739587.01753.0DomainFibronectin type-III 4
HgeneITGB4chr17:73732235chr12:53345903ENST00000579662+1439979_1084587.01753.0DomainNote=Calx-beta
HgeneITGB4chr17:73732235chr12:53345903ENST00000200181+1440456_619587.01823.0RegionNote=Cysteine-rich tandem repeats
HgeneITGB4chr17:73732235chr12:53345903ENST00000200181+1440732_749587.01823.0RegionNote=Palmitoylated on several cysteines
HgeneITGB4chr17:73732235chr12:53345903ENST00000339591+1440456_619587.01806.0RegionNote=Cysteine-rich tandem repeats
HgeneITGB4chr17:73732235chr12:53345903ENST00000339591+1440732_749587.01806.0RegionNote=Palmitoylated on several cysteines
HgeneITGB4chr17:73732235chr12:53345903ENST00000449880+1339456_619587.01806.0RegionNote=Cysteine-rich tandem repeats
HgeneITGB4chr17:73732235chr12:53345903ENST00000449880+1339732_749587.01806.0RegionNote=Palmitoylated on several cysteines
HgeneITGB4chr17:73732235chr12:53345903ENST00000450894+1439456_619587.01753.0RegionNote=Cysteine-rich tandem repeats
HgeneITGB4chr17:73732235chr12:53345903ENST00000450894+1439732_749587.01753.0RegionNote=Palmitoylated on several cysteines
HgeneITGB4chr17:73732235chr12:53345903ENST00000579662+1439456_619587.01753.0RegionNote=Cysteine-rich tandem repeats
HgeneITGB4chr17:73732235chr12:53345903ENST00000579662+1439732_749587.01753.0RegionNote=Palmitoylated on several cysteines
HgeneITGB4chr17:73732235chr12:53345903ENST00000200181+1440582_619587.01823.0RepeatNote=IV
HgeneITGB4chr17:73732235chr12:53345903ENST00000339591+1440582_619587.01806.0RepeatNote=IV
HgeneITGB4chr17:73732235chr12:53345903ENST00000449880+1339582_619587.01806.0RepeatNote=IV
HgeneITGB4chr17:73732235chr12:53345903ENST00000450894+1439582_619587.01753.0RepeatNote=IV
HgeneITGB4chr17:73732235chr12:53345903ENST00000579662+1439582_619587.01753.0RepeatNote=IV
HgeneITGB4chr17:73732235chr12:53345903ENST00000200181+144028_710587.01823.0Topological domainExtracellular
HgeneITGB4chr17:73732235chr12:53345903ENST00000200181+1440734_1822587.01823.0Topological domainCytoplasmic
HgeneITGB4chr17:73732235chr12:53345903ENST00000339591+144028_710587.01806.0Topological domainExtracellular
HgeneITGB4chr17:73732235chr12:53345903ENST00000339591+1440734_1822587.01806.0Topological domainCytoplasmic
HgeneITGB4chr17:73732235chr12:53345903ENST00000449880+133928_710587.01806.0Topological domainExtracellular
HgeneITGB4chr17:73732235chr12:53345903ENST00000449880+1339734_1822587.01806.0Topological domainCytoplasmic
HgeneITGB4chr17:73732235chr12:53345903ENST00000450894+143928_710587.01753.0Topological domainExtracellular
HgeneITGB4chr17:73732235chr12:53345903ENST00000450894+1439734_1822587.01753.0Topological domainCytoplasmic
HgeneITGB4chr17:73732235chr12:53345903ENST00000579662+143928_710587.01753.0Topological domainExtracellular
HgeneITGB4chr17:73732235chr12:53345903ENST00000579662+1439734_1822587.01753.0Topological domainCytoplasmic
HgeneITGB4chr17:73732235chr12:53345903ENST00000200181+1440711_733587.01823.0TransmembraneHelical
HgeneITGB4chr17:73732235chr12:53345903ENST00000339591+1440711_733587.01806.0TransmembraneHelical
HgeneITGB4chr17:73732235chr12:53345903ENST00000449880+1339711_733587.01806.0TransmembraneHelical
HgeneITGB4chr17:73732235chr12:53345903ENST00000450894+1439711_733587.01753.0TransmembraneHelical
HgeneITGB4chr17:73732235chr12:53345903ENST00000579662+1439711_733587.01753.0TransmembraneHelical
TgeneKRT18chr17:73732235chr12:53345903ENST000003888354780_391316.0431.0DomainIF rod
TgeneKRT18chr17:73732235chr12:53345903ENST000003888375880_391316.0431.0DomainIF rod
TgeneKRT18chr17:73732235chr12:53345903ENST0000038883547116_132316.0431.0RegionNote=Linker 1
TgeneKRT18chr17:73732235chr12:53345903ENST0000038883547133_224316.0431.0RegionNote=Coil 1B
TgeneKRT18chr17:73732235chr12:53345903ENST0000038883547225_248316.0431.0RegionNote=Linker 12
TgeneKRT18chr17:73732235chr12:53345903ENST0000038883547249_387316.0431.0RegionNote=Coil 2
TgeneKRT18chr17:73732235chr12:53345903ENST00000388835472_79316.0431.0RegionNote=Head
TgeneKRT18chr17:73732235chr12:53345903ENST000003888354780_115316.0431.0RegionNote=Coil 1A
TgeneKRT18chr17:73732235chr12:53345903ENST0000038883758116_132316.0431.0RegionNote=Linker 1
TgeneKRT18chr17:73732235chr12:53345903ENST0000038883758133_224316.0431.0RegionNote=Coil 1B
TgeneKRT18chr17:73732235chr12:53345903ENST0000038883758225_248316.0431.0RegionNote=Linker 12
TgeneKRT18chr17:73732235chr12:53345903ENST0000038883758249_387316.0431.0RegionNote=Coil 2
TgeneKRT18chr17:73732235chr12:53345903ENST00000388837582_79316.0431.0RegionNote=Head
TgeneKRT18chr17:73732235chr12:53345903ENST000003888375880_115316.0431.0RegionNote=Coil 1A


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ITGB4
KRT18


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneKRT18chr17:73732235chr12:53345903ENST0000038883547243_391316.0431.0DNAJB6
TgeneKRT18chr17:73732235chr12:53345903ENST0000038883758243_391316.0431.0DNAJB6
TgeneKRT18chr17:73732235chr12:53345903ENST000003888354777_128316.0431.0TRADD
TgeneKRT18chr17:73732235chr12:53345903ENST000003888375877_128316.0431.0TRADD


Top

Related Drugs to ITGB4-KRT18


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to ITGB4-KRT18


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource