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Fusion Protein:JAZF1-SUZ12 |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: JAZF1-SUZ12 | FusionPDB ID: 40918 | FusionGDB2.0 ID: 40918 | Hgene | Tgene | Gene symbol | JAZF1 | SUZ12 | Gene ID | 221895 | 23512 |
Gene name | JAZF zinc finger 1 | SUZ12 polycomb repressive complex 2 subunit | |
Synonyms | TIP27|ZNF802 | CHET9|IMMAS|JJAZ1 | |
Cytomap | 7p15.2-p15.1 | 17q11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | juxtaposed with another zinc finger protein 1TAK1-interacting protein 27juxtaposed with another zinc finger gene 1zinc finger protein 802 | polycomb protein SUZ12chET 9 proteinchromatin precipitated E2F target 9 proteinjoined to JAZF1 proteinsuppressor of zeste 12 protein homolog | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q86VZ6 | Q15022 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000283928, ENST00000466516, | ENST00000322652, ENST00000580398, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 21 X 19 X 11=4389 | 10 X 8 X 5=400 |
# samples | 26 | 8 | |
** MAII score | log2(26/4389*10)=-4.07730874183119 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/400*10)=-2.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: JAZF1 [Title/Abstract] AND SUZ12 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | |||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | JAZF1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 15302918 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerKB3 | . | . | JAZF1 | chr7 | 27934838 | - | SUZ12 | chr17 | 30267304 | + |
ChimerKB3 | . | . | JAZF1 | chr7 | 28225371 | - | SUZ12 | chr17 | 30267304 | + |
ChimerKB3 | . | . | JAZF1 | chr7 | 28256968 | - | SUZ12 | chr17 | 30267304 | + |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000283928 | JAZF1 | chr7 | 27934838 | - | ENST00000322652 | SUZ12 | chr17 | 30267304 | + | 4539 | 551 | 166 | 2496 | 776 |
ENST00000283928 | JAZF1 | chr7 | 27934838 | - | ENST00000580398 | SUZ12 | chr17 | 30267304 | + | 4074 | 551 | 166 | 2427 | 753 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >40918_40918_1_JAZF1-SUZ12_JAZF1_chr7_27934838_ENST00000283928_SUZ12_chr17_30267304_ENST00000322652_length(amino acids)=776AA_BP=128 MTGIAAASFFSNTCRFGGCGLHFPTLADLIEHIEDNHIDTDPRVLEKQELQQPTYVALSYINRFMTDAARREQESLKKKIQPKLSLTLSS SVSRGNVSTPPRHSSGSLTPPVTPPITPSSSFRSSTPTEPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEK MKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVS SNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEME ECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTR KEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNP QDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLR EKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLRE -------------------------------------------------------------- >40918_40918_2_JAZF1-SUZ12_JAZF1_chr7_27934838_ENST00000283928_SUZ12_chr17_30267304_ENST00000580398_length(amino acids)=753AA_BP=128 MTGIAAASFFSNTCRFGGCGLHFPTLADLIEHIEDNHIDTDPRVLEKQELQQPTYVALSYINRFMTDAARREQESLKKKIQPKLSLTLSS SVSRGNVSTPPRHSSGSLTPPVTPPITPSSSFRSSTPTEPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKSLSAHLQLTFTGFFH KNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTR PGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPF ETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNN NTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPIT HILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKL WNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQN -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:/chr17:) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
JAZF1 | SUZ12 |
FUNCTION: Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2 (PubMed:15302918). Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (By similarity). Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (By similarity). Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (By similarity). Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (By similarity). {ECO:0000250|UniProtKB:Q80ZQ5, ECO:0000269|PubMed:15302918}. | FUNCTION: Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12435631, PubMed:12351676, PubMed:15385962, PubMed:15099518, PubMed:15225548, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464). Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557). {ECO:0000269|PubMed:12351676, ECO:0000269|PubMed:12435631, ECO:0000269|PubMed:15099518, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:15684044, ECO:0000269|PubMed:16431907, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:17200670, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Protein Structures |
![]() * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
PDB file (618) >>>618.pdbFusion protein BP residue: 128 CIF file (618) >>>618.cif | JAZF1 | chr7 | 27934838 | - | SUZ12 | chr17 | 30267304 | + | MTGIAAASFFSNTCRFGGCGLHFPTLADLIEHIEDNHIDTDPRVLEKQEL QQPTYVALSYINRFMTDAARREQESLKKKIQPKLSLTLSSSVSRGNVSTP PRHSSGSLTPPVTPPITPSSSFRSSTPTEPTQIYRFLRTRNLIAPIFLHR TLTYMSHRNSRTNIKSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEV LLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNE FEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKR NREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWET ILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLH QENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNN NTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGAR IDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRT KASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDE KDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHAC MLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQ KLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKK | 753 |
3D view using mol* of 618 (AA BP:128) | ||||||||||
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PDB file (634) >>>634.pdbFusion protein BP residue: 128 CIF file (634) >>>634.cif | JAZF1 | chr7 | 27934838 | - | SUZ12 | chr17 | 30267304 | + | MTGIAAASFFSNTCRFGGCGLHFPTLADLIEHIEDNHIDTDPRVLEKQEL QQPTYVALSYINRFMTDAARREQESLKKKIQPKLSLTLSSSVSRGNVSTP PRHSSGSLTPPVTPPITPSSSFRSSTPTEPTQIYRFLRTRNLIAPIFLHR TLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTG FFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQV PLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFN GMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDG EYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTG ETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTR KEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSL LKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFA FSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNR LYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEV MKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSM HDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFS | 776 |
3D view using mol* of 634 (AA BP:128) | ||||||||||
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pLDDT score distribution |
![]() * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
JAZF1_pLDDT.png![]() |
SUZ12_pLDDT.png![]() |
![]() * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
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Ramachandran Plot of Fusion Protein Structure |
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Fusion AA seq ID in FusionPDB and their Ramachandran plots |
JAZF1_SUZ12_618.png |
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JAZF1_SUZ12_634.png |
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Potential Active Site Information |
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Fusion AA seq ID in FusionPDB | Site score | Size | D score | Volume | Exposure | Enclosure | Contact | Phobic | Philic | Balance | Don/Acc | Residues |
618 | 1.003 | 132 | 1.065 | 342.314 | 0.677 | 0.623 | 0.824 | 0.783 | 0.764 | 1.024 | 0.537 | Chain A: 510,512,513,517,518,519,520,521,522,523,5 24,525,526,528,529,534,535,536,537,538,539,540,541 ,572,576,581,586,587,589,590,591,592 |
634 | 1.063 | 172 | 1.118 | 518.616 | 0.539 | 0.713 | 0.949 | 1.172 | 0.766 | 1.529 | 0.921 | Chain A: 58,59,61,62,63,64,65,118,122,123,124,125, 126,127,128,131,135,467,469,470,471,476,477,479,48 0,482,486,487,488,489,491,511 |
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Potentially Interacting Small Molecules through Virtual Screening |
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Fusion AA seq ID in FusionPDB | ZINC ID | DrugBank ID | Drug name | Docking score | Glide gscore |
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ZINC ID | DrugBank ID | Drug name | Drug type | SMILES | Drug group |
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Biochemical Features of Small Molecules |
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ZINC ID | mol_MW | dipole | SASA | FOSA | FISA | PISA | WPSA | volume | donorHB | accptHB | IP | Human Oral Absorption | Percent Human Oral Absorption | Rule Of Five | Rule Of Three |
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Drug Toxicity Information |
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ZINC ID | Smile | Surface Accessibility | Toxicity |
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Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
JAZF1 | NR2C2, PPARG, RXRA, YEATS4, TRRAP, Ruvbl1, MEAF6, RUVBL1, MYCL, HIST1H2BA, MORF4L2, HIST1H4A, FAM9B, BRD8, SUZ12, KAT5, EP400, DMAP1, EPC1, EPC2, MBTD1, MRGBP, DDX39A, NR2C1, METAP2, CLTCL1, H2AFZ, VPS72, ACAD11, ING3, ING5, |
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Gene | STRING network |
JAZF1 | ![]() |
SUZ12 | ![]() |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to JAZF1-SUZ12 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to JAZF1-SUZ12 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
JAZF1 | SUZ12 | Low-Grade Endometrial Stromal Sarcoma | MyCancerGenome | |
JAZF1 | SUZ12 | Acute Myeloid Leukemia | MyCancerGenome | |
JAZF1 | SUZ12 | Adenocarcinoma Of Unknown Primary | MyCancerGenome | |
JAZF1 | SUZ12 | Breast Invasive Ductal Carcinoma | MyCancerGenome | |
JAZF1 | SUZ12 | Conventional Glioblastoma Multiforme | MyCancerGenome |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | JAZF1 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
Hgene | JAZF1 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
Hgene | JAZF1 | C0024141 | Lupus Erythematosus, Systemic | 1 | CTD_human;ORPHANET |
Hgene | JAZF1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | JAZF1 | C0206630 | Endometrial Stromal Sarcoma | 1 | ORPHANET |
Hgene | JAZF1 | C0242380 | Libman-Sacks Disease | 1 | CTD_human |
Hgene | JAZF1 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
Hgene | JAZF1 | C0476089 | Endometrial Carcinoma | 1 | CTD_human |
Tgene | SUZ12 | C0206727 | Nerve Sheath Tumors | 2 | CTD_human |
Tgene | SUZ12 | C0751689 | Peripheral Nerve Sheath Neoplasm | 2 | CTD_human |
Tgene | SUZ12 | C0751691 | Perineurioma | 2 | CTD_human |
Tgene | SUZ12 | C0001430 | Adenoma | 1 | CTD_human |
Tgene | SUZ12 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
Tgene | SUZ12 | C0017636 | Glioblastoma | 1 | CTD_human |
Tgene | SUZ12 | C0017638 | Glioma | 1 | CTD_human |
Tgene | SUZ12 | C0025202 | melanoma | 1 | CTD_human |
Tgene | SUZ12 | C0027809 | Neurilemmoma | 1 | CTD_human |
Tgene | SUZ12 | C0027830 | neurofibroma | 1 | CTD_human |
Tgene | SUZ12 | C0027962 | Melanocytic nevus | 1 | CTD_human |
Tgene | SUZ12 | C0042063 | Urogenital Abnormalities | 1 | GENOMICS_ENGLAND |
Tgene | SUZ12 | C0205646 | Adenoma, Basal Cell | 1 | CTD_human |
Tgene | SUZ12 | C0205647 | Follicular adenoma | 1 | CTD_human |
Tgene | SUZ12 | C0205648 | Adenoma, Microcystic | 1 | CTD_human |
Tgene | SUZ12 | C0205649 | Adenoma, Monomorphic | 1 | CTD_human |
Tgene | SUZ12 | C0205650 | Papillary adenoma | 1 | CTD_human |
Tgene | SUZ12 | C0205651 | Adenoma, Trabecular | 1 | CTD_human |
Tgene | SUZ12 | C0206630 | Endometrial Stromal Sarcoma | 1 | ORPHANET |
Tgene | SUZ12 | C0259783 | mixed gliomas | 1 | CTD_human |
Tgene | SUZ12 | C0265210 | Weaver syndrome | 1 | ORPHANET |
Tgene | SUZ12 | C0334588 | Giant Cell Glioblastoma | 1 | CTD_human |
Tgene | SUZ12 | C0476089 | Endometrial Carcinoma | 1 | CTD_human |
Tgene | SUZ12 | C0545053 | Advanced bone age | 1 | GENOMICS_ENGLAND |
Tgene | SUZ12 | C0555198 | Malignant Glioma | 1 | CTD_human |
Tgene | SUZ12 | C0557874 | Global developmental delay | 1 | GENOMICS_ENGLAND |
Tgene | SUZ12 | C0751374 | Schwannomatosis, Plexiform | 1 | CTD_human |
Tgene | SUZ12 | C1621958 | Glioblastoma Multiforme | 1 | CTD_human |
Tgene | SUZ12 | C1842581 | Abnormal corpus callosum morphology | 1 | GENOMICS_ENGLAND |
Tgene | SUZ12 | C1849265 | Overgrowth | 1 | GENOMICS_ENGLAND |
Tgene | SUZ12 | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND |
Tgene | SUZ12 | C4018871 | Abnormality of the respiratory system | 1 | GENOMICS_ENGLAND |
Tgene | SUZ12 | C4021664 | Abnormality of the abdominal wall | 1 | GENOMICS_ENGLAND |
Tgene | SUZ12 | C4021790 | Abnormality of the skeletal system | 1 | GENOMICS_ENGLAND |