UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level1

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:JMJD6-CD300LF

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: JMJD6-CD300LF
	FusionPDB ID: 40989
	FusionGDB2.0 ID: 40989
		Hgene	Tgene
	Gene symbol	JMJD6	CD300LF
	Gene ID	23210	146722
	Gene name	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	CD300 molecule like family member f
	Synonyms	PSR\|PTDSR\|PTDSR1	CD300f\|CLM-1\|CLM1\|IREM-1\|IREM1\|IgSF13\|LMIR3\|NKIR
	Cytomap	17q25.1	17q25.1
	Type of gene	protein-coding	protein-coding
	Description	bifunctional arginine demethylase and lysyl-hydroxylase JMJD6arginine demethylase and lysine hydroxylasehistone arginine demethylase JMJD6jmjC domain-containing protein 6jumonji domain containing 6jumonji domain-containing protein 6lysyl-hydroxylase	CMRF35-like molecule 1CD300 antigen-like family member FNK inhibitory receptorimmune receptor expressed on myeloid cells 1immunoglobin superfamily member 13immunoglobulin superfamily member 13inhibitory receptor IREM1
	Modification date	20200313	20200313
	UniProtAcc	Q6NYC1	Q8TDQ1
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000397625, ENST00000445478, ENST00000585429,	ENST00000301573, ENST00000343125, ENST00000361254, ENST00000326165, ENST00000464910, ENST00000469092, ENST00000581500, ENST00000583937,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	4 X 5 X 2=40	1 X 1 X 1=1
	# samples	4	1
	** MAII score	log2(4/40*10)=0	log2(1/1*10)=3.32192809488736
Context (manual curation of fusion genes in FusionPDB)	PubMed: JMJD6 [Title/Abstract] AND CD300LF [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	JMJD6(74719853)-CD300LF(72700955), # samples:1
Anticipated loss of major functional domain due to fusion event.	JMJD6-CD300LF seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. JMJD6-CD300LF seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. JMJD6-CD300LF seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. JMJD6-CD300LF seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. JMJD6-CD300LF seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. JMJD6-CD300LF seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. JMJD6-CD300LF seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	JMJD6	GO:0006482	protein demethylation	24498420
Hgene	JMJD6	GO:0018395	peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine	19574390\|22189873
Hgene	JMJD6	GO:0035513	oxidative RNA demethylation	24360279
Hgene	JMJD6	GO:0045944	positive regulation of transcription by RNA polymerase II	24360279
Hgene	JMJD6	GO:0051260	protein homooligomerization	22189873\|24360279
Hgene	JMJD6	GO:0070078	histone H3-R2 demethylation	17947579
Hgene	JMJD6	GO:0070078	histone H3-R2 demethylation	22189873
Hgene	JMJD6	GO:0070079	histone H4-R3 demethylation	17947579\|24360279\|24498420
Hgene	JMJD6	GO:0070079	histone H4-R3 demethylation	22189873
Tgene	CD300LF	GO:0033004	negative regulation of mast cell activation	24035150

Fusion gene breakpoints across JMJD6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CD300LF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-L5-A4OW	JMJD6	chr17	74719853	-	CD300LF	chr17	72700955	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000445478	JMJD6	chr17	74719853	-	ENST00000326165	CD300LF	chr17	72700955	-	2618	1009	108	1838	576
ENST00000445478	JMJD6	chr17	74719853	-	ENST00000469092	CD300LF	chr17	72700955	-	2505	1009	108	1541	477
ENST00000445478	JMJD6	chr17	74719853	-	ENST00000583937	CD300LF	chr17	72700955	-	2166	1009	108	1883	591
ENST00000445478	JMJD6	chr17	74719853	-	ENST00000464910	CD300LF	chr17	72700955	-	1898	1009	108	1838	576
ENST00000445478	JMJD6	chr17	74719853	-	ENST00000581500	CD300LF	chr17	72700955	-	1677	1009	108	1676	522
ENST00000397625	JMJD6	chr17	74719853	-	ENST00000326165	CD300LF	chr17	72700955	-	2529	920	19	1749	576
ENST00000397625	JMJD6	chr17	74719853	-	ENST00000469092	CD300LF	chr17	72700955	-	2416	920	19	1452	477
ENST00000397625	JMJD6	chr17	74719853	-	ENST00000583937	CD300LF	chr17	72700955	-	2077	920	19	1794	591
ENST00000397625	JMJD6	chr17	74719853	-	ENST00000464910	CD300LF	chr17	72700955	-	1809	920	19	1749	576
ENST00000397625	JMJD6	chr17	74719853	-	ENST00000581500	CD300LF	chr17	72700955	-	1588	920	19	1587	523
ENST00000585429	JMJD6	chr17	74719853	-	ENST00000326165	CD300LF	chr17	72700955	-	2442	833	28	1662	544
ENST00000585429	JMJD6	chr17	74719853	-	ENST00000469092	CD300LF	chr17	72700955	-	2329	833	28	1365	445
ENST00000585429	JMJD6	chr17	74719853	-	ENST00000583937	CD300LF	chr17	72700955	-	1990	833	28	1707	559
ENST00000585429	JMJD6	chr17	74719853	-	ENST00000464910	CD300LF	chr17	72700955	-	1722	833	28	1662	544
ENST00000585429	JMJD6	chr17	74719853	-	ENST00000581500	CD300LF	chr17	72700955	-	1501	833	28	1500	491

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000445478	ENST00000326165	JMJD6	chr17	74719853	-	CD300LF	chr17	72700955	-	0.007352324	0.99264765
ENST00000445478	ENST00000469092	JMJD6	chr17	74719853	-	CD300LF	chr17	72700955	-	0.009955383	0.9900446
ENST00000445478	ENST00000583937	JMJD6	chr17	74719853	-	CD300LF	chr17	72700955	-	0.014009317	0.9859907
ENST00000445478	ENST00000464910	JMJD6	chr17	74719853	-	CD300LF	chr17	72700955	-	0.011326707	0.98867327
ENST00000445478	ENST00000581500	JMJD6	chr17	74719853	-	CD300LF	chr17	72700955	-	0.01329285	0.9867071
ENST00000397625	ENST00000326165	JMJD6	chr17	74719853	-	CD300LF	chr17	72700955	-	0.00685343	0.9931466
ENST00000397625	ENST00000469092	JMJD6	chr17	74719853	-	CD300LF	chr17	72700955	-	0.00911626	0.99088377
ENST00000397625	ENST00000583937	JMJD6	chr17	74719853	-	CD300LF	chr17	72700955	-	0.013235284	0.98676467
ENST00000397625	ENST00000464910	JMJD6	chr17	74719853	-	CD300LF	chr17	72700955	-	0.010011022	0.9899889
ENST00000397625	ENST00000581500	JMJD6	chr17	74719853	-	CD300LF	chr17	72700955	-	0.011691291	0.98830867
ENST00000585429	ENST00000326165	JMJD6	chr17	74719853	-	CD300LF	chr17	72700955	-	0.007450308	0.99254966
ENST00000585429	ENST00000469092	JMJD6	chr17	74719853	-	CD300LF	chr17	72700955	-	0.009779428	0.99022055
ENST00000585429	ENST00000583937	JMJD6	chr17	74719853	-	CD300LF	chr17	72700955	-	0.014256421	0.9857436
ENST00000585429	ENST00000464910	JMJD6	chr17	74719853	-	CD300LF	chr17	72700955	-	0.010716846	0.9892832
ENST00000585429	ENST00000581500	JMJD6	chr17	74719853	-	CD300LF	chr17	72700955	-	0.012517743	0.9874822

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>40989_40989_1_JMJD6-CD300LF_JMJD6_chr17_74719853_ENST00000397625_CD300LF_chr17_72700955_ENST00000326165_length(amino acids)=576AA_BP=1
MPSPPPRPGRGALVSGSGLRRGRSGTSWRPRRMNHKSKKRIREAKRSARPELKDSLDWTRHNYYESFSLSPAAVADNVERADALQLSVEE
FVERYERPYKPVVLLNAQEGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLE
DYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTSTPRELIKVTRDEGGNQQDEAITWFNV
IYPRTQLPTWPPEFKPLEILQKPGETVFVPGYSIVTQITGPTTVNGLERGSLTVQCVYRSGWETYLKWWCRGAIWRDCKILVKTSGSEQE
VKRDRVSIKDNQKNRTFTVTMEDLMKTDADTYWCGIEKTGNDLGVTVQVTIDPAPVTQEETSSSPTLTGHHLDNRHKLLKLSVLLPLIFT
ILLLLLVAASLLAWRMMKYQQKAAGMSPEQVLQPLEGDLCYADLTLQLAGTSPQKATTKLSSAQVDQVEVEYVTMASLPKEDISYASLTL

--------------------------------------------------------------

>40989_40989_2_JMJD6-CD300LF_JMJD6_chr17_74719853_ENST00000397625_CD300LF_chr17_72700955_ENST00000464910_length(amino acids)=576AA_BP=1
MPSPPPRPGRGALVSGSGLRRGRSGTSWRPRRMNHKSKKRIREAKRSARPELKDSLDWTRHNYYESFSLSPAAVADNVERADALQLSVEE
FVERYERPYKPVVLLNAQEGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLE
DYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTSTPRELIKVTRDEGGNQQDEAITWFNV
IYPRTQLPTWPPEFKPLEILQKPGETVFVPGYSIVTQITGPTTVNGLERGSLTVQCVYRSGWETYLKWWCRGAIWRDCKILVKTSGSEQE
VKRDRVSIKDNQKNRTFTVTMEDLMKTDADTYWCGIEKTGNDLGVTVQVTIDPAPVTQEETSSSPTLTGHHLDNRHKLLKLSVLLPLIFT
ILLLLLVAASLLAWRMMKYQQKAAGMSPEQVLQPLEGDLCYADLTLQLAGTSPQKATTKLSSAQVDQVEVEYVTMASLPKEDISYASLTL

--------------------------------------------------------------

>40989_40989_3_JMJD6-CD300LF_JMJD6_chr17_74719853_ENST00000397625_CD300LF_chr17_72700955_ENST00000469092_length(amino acids)=477AA_BP=1
MPSPPPRPGRGALVSGSGLRRGRSGTSWRPRRMNHKSKKRIREAKRSARPELKDSLDWTRHNYYESFSLSPAAVADNVERADALQLSVEE
FVERYERPYKPVVLLNAQEGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLE
DYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTSTPRELIKVTRDEGGNQQDEAITWFNV
IYPRTQLPTWPPEFKPLEILQKPGETVFVPGYSIVTQITGPTTVNGLERGSLTVQCVYRSGWETYLKWWCRGAIWRDCKILVKTSGSEQE
VKRDRVSIKDNQKNRTFTVTMEDLMKTDADTYWCGIEKTGNDLGVTVQVTIDPAPVTQEETSSSPTLTGHHLDNSSRDVPRAGTAAPGGR

--------------------------------------------------------------

>40989_40989_4_JMJD6-CD300LF_JMJD6_chr17_74719853_ENST00000397625_CD300LF_chr17_72700955_ENST00000581500_length(amino acids)=523AA_BP=1
MPSPPPRPGRGALVSGSGLRRGRSGTSWRPRRMNHKSKKRIREAKRSARPELKDSLDWTRHNYYESFSLSPAAVADNVERADALQLSVEE
FVERYERPYKPVVLLNAQEGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLE
DYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTSTPRELIKVTRDEGGNQQDEAITWFNV
IYPRTQLPTWPPEFKPLEILQKPGETVFVPGYSIVTQITGPTTVNGLERGSLTVQCVYRSGWETYLKWWCRGAIWRDCKILVKTSGSEQE
VKRDRVSIKDNQKNRTFTVTMEDLMKTDADTYWCGIEKTGNDLGVTVQVTIDPASTPAPTTPTSTTFTAPVTQEETSSSPTLTGHHLDNR

--------------------------------------------------------------

>40989_40989_5_JMJD6-CD300LF_JMJD6_chr17_74719853_ENST00000397625_CD300LF_chr17_72700955_ENST00000583937_length(amino acids)=591AA_BP=1
MPSPPPRPGRGALVSGSGLRRGRSGTSWRPRRMNHKSKKRIREAKRSARPELKDSLDWTRHNYYESFSLSPAAVADNVERADALQLSVEE
FVERYERPYKPVVLLNAQEGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLE
DYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTSTPRELIKVTRDEGGNQQDEAITWFNV
IYPRTQLPTWPPEFKPLEILQKPGETVFVPGYSIVTQITGPTTVNGLERGSLTVQCVYRSGWETYLKWWCRGAIWRDCKILVKTSGSEQE
VKRDRVSIKDNQKNRTFTVTMEDLMKTDADTYWCGIEKTGNDLGVTVQVTIDPASTPAPTTPTSTTFTAPVTQEETSSSPTLTGHHLDNR
HKLLKLSVLLPLIFTILLLLLVAASLLAWRMMKYQQKAAGMSPEQVLQPLEGDLCYADLTLQLAGTSPQKATTKLSSAQVDQVEVEYVTM

--------------------------------------------------------------

>40989_40989_6_JMJD6-CD300LF_JMJD6_chr17_74719853_ENST00000445478_CD300LF_chr17_72700955_ENST00000326165_length(amino acids)=576AA_BP=1
MPSPPPRPGRGALVSGSGLRRGRSGTSWRPRRMNHKSKKRIREAKRSARPELKDSLDWTRHNYYESFSLSPAAVADNVERADALQLSVEE
FVERYERPYKPVVLLNAQEGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLE
DYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTSTPRELIKVTRDEGGNQQDEAITWFNV
IYPRTQLPTWPPEFKPLEILQKPGETVFVPGYSIVTQITGPTTVNGLERGSLTVQCVYRSGWETYLKWWCRGAIWRDCKILVKTSGSEQE
VKRDRVSIKDNQKNRTFTVTMEDLMKTDADTYWCGIEKTGNDLGVTVQVTIDPAPVTQEETSSSPTLTGHHLDNRHKLLKLSVLLPLIFT
ILLLLLVAASLLAWRMMKYQQKAAGMSPEQVLQPLEGDLCYADLTLQLAGTSPQKATTKLSSAQVDQVEVEYVTMASLPKEDISYASLTL

--------------------------------------------------------------

>40989_40989_7_JMJD6-CD300LF_JMJD6_chr17_74719853_ENST00000445478_CD300LF_chr17_72700955_ENST00000464910_length(amino acids)=576AA_BP=1
MPSPPPRPGRGALVSGSGLRRGRSGTSWRPRRMNHKSKKRIREAKRSARPELKDSLDWTRHNYYESFSLSPAAVADNVERADALQLSVEE
FVERYERPYKPVVLLNAQEGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLE
DYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTSTPRELIKVTRDEGGNQQDEAITWFNV
IYPRTQLPTWPPEFKPLEILQKPGETVFVPGYSIVTQITGPTTVNGLERGSLTVQCVYRSGWETYLKWWCRGAIWRDCKILVKTSGSEQE
VKRDRVSIKDNQKNRTFTVTMEDLMKTDADTYWCGIEKTGNDLGVTVQVTIDPAPVTQEETSSSPTLTGHHLDNRHKLLKLSVLLPLIFT
ILLLLLVAASLLAWRMMKYQQKAAGMSPEQVLQPLEGDLCYADLTLQLAGTSPQKATTKLSSAQVDQVEVEYVTMASLPKEDISYASLTL

--------------------------------------------------------------

>40989_40989_8_JMJD6-CD300LF_JMJD6_chr17_74719853_ENST00000445478_CD300LF_chr17_72700955_ENST00000469092_length(amino acids)=477AA_BP=1
MPSPPPRPGRGALVSGSGLRRGRSGTSWRPRRMNHKSKKRIREAKRSARPELKDSLDWTRHNYYESFSLSPAAVADNVERADALQLSVEE
FVERYERPYKPVVLLNAQEGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLE
DYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTSTPRELIKVTRDEGGNQQDEAITWFNV
IYPRTQLPTWPPEFKPLEILQKPGETVFVPGYSIVTQITGPTTVNGLERGSLTVQCVYRSGWETYLKWWCRGAIWRDCKILVKTSGSEQE
VKRDRVSIKDNQKNRTFTVTMEDLMKTDADTYWCGIEKTGNDLGVTVQVTIDPAPVTQEETSSSPTLTGHHLDNSSRDVPRAGTAAPGGR

--------------------------------------------------------------

>40989_40989_9_JMJD6-CD300LF_JMJD6_chr17_74719853_ENST00000445478_CD300LF_chr17_72700955_ENST00000581500_length(amino acids)=522AA_BP=1
MPSPPPRPGRGALVSGSGLRRGRSGTSWRPRRMNHKSKKRIREAKRSARPELKDSLDWTRHNYYESFSLSPAAVADNVERADALQLSVEE
FVERYERPYKPVVLLNAQEGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLE
DYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTSTPRELIKVTRDEGGNQQDEAITWFNV
IYPRTQLPTWPPEFKPLEILQKPGETVFVPGYSIVTQITGPTTVNGLERGSLTVQCVYRSGWETYLKWWCRGAIWRDCKILVKTSGSEQE
VKRDRVSIKDNQKNRTFTVTMEDLMKTDADTYWCGIEKTGNDLGVTVQVTIDPASTPAPTTPTSTTFTAPVTQEETSSSPTLTGHHLDNR

--------------------------------------------------------------

>40989_40989_10_JMJD6-CD300LF_JMJD6_chr17_74719853_ENST00000445478_CD300LF_chr17_72700955_ENST00000583937_length(amino acids)=591AA_BP=1
MPSPPPRPGRGALVSGSGLRRGRSGTSWRPRRMNHKSKKRIREAKRSARPELKDSLDWTRHNYYESFSLSPAAVADNVERADALQLSVEE
FVERYERPYKPVVLLNAQEGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLE
DYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTSTPRELIKVTRDEGGNQQDEAITWFNV
IYPRTQLPTWPPEFKPLEILQKPGETVFVPGYSIVTQITGPTTVNGLERGSLTVQCVYRSGWETYLKWWCRGAIWRDCKILVKTSGSEQE
VKRDRVSIKDNQKNRTFTVTMEDLMKTDADTYWCGIEKTGNDLGVTVQVTIDPASTPAPTTPTSTTFTAPVTQEETSSSPTLTGHHLDNR
HKLLKLSVLLPLIFTILLLLLVAASLLAWRMMKYQQKAAGMSPEQVLQPLEGDLCYADLTLQLAGTSPQKATTKLSSAQVDQVEVEYVTM

--------------------------------------------------------------

>40989_40989_11_JMJD6-CD300LF_JMJD6_chr17_74719853_ENST00000585429_CD300LF_chr17_72700955_ENST00000326165_length(amino acids)=544AA_BP=0
MNHKSKKRIREAKRSARPELKDSLDWTRHNYYESFSLSPAAVADNVERADALQLSVEEFVERYERPYKPVVLLNAQEGWSAQEKWTLERL
KRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLEDYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPP
RSGTGIHIDPLGTSAWNALVQGHKRWCLFPTSTPRELIKVTRDEGGNQQDEAITWFNVIYPRTQLPTWPPEFKPLEILQKPGETVFVPGY
SIVTQITGPTTVNGLERGSLTVQCVYRSGWETYLKWWCRGAIWRDCKILVKTSGSEQEVKRDRVSIKDNQKNRTFTVTMEDLMKTDADTY
WCGIEKTGNDLGVTVQVTIDPAPVTQEETSSSPTLTGHHLDNRHKLLKLSVLLPLIFTILLLLLVAASLLAWRMMKYQQKAAGMSPEQVL
QPLEGDLCYADLTLQLAGTSPQKATTKLSSAQVDQVEVEYVTMASLPKEDISYASLTLGAEDQEPTYCNMGHLSSHLPGRGPEEPTEYST

--------------------------------------------------------------

>40989_40989_12_JMJD6-CD300LF_JMJD6_chr17_74719853_ENST00000585429_CD300LF_chr17_72700955_ENST00000464910_length(amino acids)=544AA_BP=0
MNHKSKKRIREAKRSARPELKDSLDWTRHNYYESFSLSPAAVADNVERADALQLSVEEFVERYERPYKPVVLLNAQEGWSAQEKWTLERL
KRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLEDYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPP
RSGTGIHIDPLGTSAWNALVQGHKRWCLFPTSTPRELIKVTRDEGGNQQDEAITWFNVIYPRTQLPTWPPEFKPLEILQKPGETVFVPGY
SIVTQITGPTTVNGLERGSLTVQCVYRSGWETYLKWWCRGAIWRDCKILVKTSGSEQEVKRDRVSIKDNQKNRTFTVTMEDLMKTDADTY
WCGIEKTGNDLGVTVQVTIDPAPVTQEETSSSPTLTGHHLDNRHKLLKLSVLLPLIFTILLLLLVAASLLAWRMMKYQQKAAGMSPEQVL
QPLEGDLCYADLTLQLAGTSPQKATTKLSSAQVDQVEVEYVTMASLPKEDISYASLTLGAEDQEPTYCNMGHLSSHLPGRGPEEPTEYST

--------------------------------------------------------------

>40989_40989_13_JMJD6-CD300LF_JMJD6_chr17_74719853_ENST00000585429_CD300LF_chr17_72700955_ENST00000469092_length(amino acids)=445AA_BP=0
MNHKSKKRIREAKRSARPELKDSLDWTRHNYYESFSLSPAAVADNVERADALQLSVEEFVERYERPYKPVVLLNAQEGWSAQEKWTLERL
KRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLEDYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPP
RSGTGIHIDPLGTSAWNALVQGHKRWCLFPTSTPRELIKVTRDEGGNQQDEAITWFNVIYPRTQLPTWPPEFKPLEILQKPGETVFVPGY
SIVTQITGPTTVNGLERGSLTVQCVYRSGWETYLKWWCRGAIWRDCKILVKTSGSEQEVKRDRVSIKDNQKNRTFTVTMEDLMKTDADTY

--------------------------------------------------------------

>40989_40989_14_JMJD6-CD300LF_JMJD6_chr17_74719853_ENST00000585429_CD300LF_chr17_72700955_ENST00000581500_length(amino acids)=491AA_BP=0
MNHKSKKRIREAKRSARPELKDSLDWTRHNYYESFSLSPAAVADNVERADALQLSVEEFVERYERPYKPVVLLNAQEGWSAQEKWTLERL
KRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLEDYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPP
RSGTGIHIDPLGTSAWNALVQGHKRWCLFPTSTPRELIKVTRDEGGNQQDEAITWFNVIYPRTQLPTWPPEFKPLEILQKPGETVFVPGY
SIVTQITGPTTVNGLERGSLTVQCVYRSGWETYLKWWCRGAIWRDCKILVKTSGSEQEVKRDRVSIKDNQKNRTFTVTMEDLMKTDADTY
WCGIEKTGNDLGVTVQVTIDPASTPAPTTPTSTTFTAPVTQEETSSSPTLTGHHLDNRHKLLKLSVLLPLIFTILLLLLVAASLLAWRMM

--------------------------------------------------------------

>40989_40989_15_JMJD6-CD300LF_JMJD6_chr17_74719853_ENST00000585429_CD300LF_chr17_72700955_ENST00000583937_length(amino acids)=559AA_BP=0
MNHKSKKRIREAKRSARPELKDSLDWTRHNYYESFSLSPAAVADNVERADALQLSVEEFVERYERPYKPVVLLNAQEGWSAQEKWTLERL
KRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLEDYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPP
RSGTGIHIDPLGTSAWNALVQGHKRWCLFPTSTPRELIKVTRDEGGNQQDEAITWFNVIYPRTQLPTWPPEFKPLEILQKPGETVFVPGY
SIVTQITGPTTVNGLERGSLTVQCVYRSGWETYLKWWCRGAIWRDCKILVKTSGSEQEVKRDRVSIKDNQKNRTFTVTMEDLMKTDADTY
WCGIEKTGNDLGVTVQVTIDPASTPAPTTPTSTTFTAPVTQEETSSSPTLTGHHLDNRHKLLKLSVLLPLIFTILLLLLVAASLLAWRMM
KYQQKAAGMSPEQVLQPLEGDLCYADLTLQLAGTSPQKATTKLSSAQVDQVEVEYVTMASLPKEDISYASLTLGAEDQEPTYCNMGHLSS

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:74719853/chr17:72700955)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
JMJD6 Q6NYC1	CD300LF Q8TDQ1
FUNCTION: Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase (PubMed:24498420, PubMed:17947579, PubMed:20684070, PubMed:21060799, PubMed:22189873). Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65 (PubMed:19574390). Hydroxylates its own N-terminus, which is required for homooligomerization (PubMed:22189873). In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA (PubMed:20679243, PubMed:29176719). Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation (PubMed:17947579, PubMed:24498420, PubMed:24360279). Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code (PubMed:17947579, PubMed:24360279). However, histone arginine demethylation may not constitute the primary activity in vivo (PubMed:17947579, PubMed:21060799, PubMed:22189873). In collaboration with BRD4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. On distal enhancers, so called anti-pause enhancers, demethylates both histone H4R3me2 and the methyl cap of 7SKsnRNA leading to the dismissal of the 7SKsnRNA:HEXIM1 inhibitor complex. After removal of repressive marks, the complex BRD4:JMJD6 attract and retain the P-TEFb complex on chromatin, leading to its activation, promoter-proximal polymerase II pause release, and transcriptional activation (PubMed:24360279). Demethylates other arginine methylated-proteins such as ESR1 (PubMed:24498420). Has no histone lysine demethylase activity (PubMed:21060799). Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65 (By similarity). Seems to be necessary for the regulation of macrophage cytokine responses (PubMed:15622002). {ECO:0000250\|UniProtKB:Q9ERI5, ECO:0000269\|PubMed:15622002, ECO:0000269\|PubMed:17947579, ECO:0000269\|PubMed:19574390, ECO:0000269\|PubMed:20679243, ECO:0000269\|PubMed:20684070, ECO:0000269\|PubMed:21060799, ECO:0000269\|PubMed:22189873, ECO:0000269\|PubMed:24360279, ECO:0000269\|PubMed:24498420, ECO:0000269\|PubMed:29176719}.	FUNCTION: Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923). Inhibits osteoclast formation. Induces macrophage cell death upon engagement (By similarity). {ECO:0000250\|UniProtKB:Q6SJQ7, ECO:0000269\|PubMed:15549731, ECO:0000269\|PubMed:22043923, ECO:0000269\|PubMed:24035150}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

JMJD6

chr17:74719853

chr17:72700955

ENST00000397625

141_145

268.3333333333333

404.0

Motif

Nuclear localization signal 3

Hgene

JMJD6

chr17:74719853

chr17:72700955

ENST00000397625

167_170

268.3333333333333

404.0

Motif

Nuclear localization signal 4

Hgene

JMJD6

chr17:74719853

chr17:72700955

ENST00000397625

6_10

268.3333333333333

404.0

Motif

Nuclear localization signal 1

Hgene

JMJD6

chr17:74719853

chr17:72700955

ENST00000397625

91_95

268.3333333333333

404.0

Motif

Nuclear localization signal 2

Hgene

JMJD6

chr17:74719853

chr17:72700955

ENST00000445478

141_145

268.3333333333333

415.0

Motif

Nuclear localization signal 3

Hgene

JMJD6

chr17:74719853

chr17:72700955

ENST00000445478

167_170

268.3333333333333

415.0

Motif

Nuclear localization signal 4

Hgene

JMJD6

chr17:74719853

chr17:72700955

ENST00000445478

6_10

268.3333333333333

415.0

Motif

Nuclear localization signal 1

Hgene

JMJD6

chr17:74719853

chr17:72700955

ENST00000445478

91_95

268.3333333333333

415.0

Motif

Nuclear localization signal 2

Tgene

CD300LF

chr17:74719853

chr17:72700955

ENST00000301573

20_126

14.333333333333334

444.6666666666667

Domain

Note=Ig-like V-type

Tgene

CD300LF

chr17:74719853

chr17:72700955

ENST00000326165

20_126

14.333333333333334

291.0

Domain

Note=Ig-like V-type

Tgene

CD300LF

chr17:74719853

chr17:72700955

ENST00000343125

20_126

17.333333333333332

422.6666666666667

Domain

Note=Ig-like V-type

Tgene

CD300LF

chr17:74719853

chr17:72700955

ENST00000361254

20_126

17.333333333333332

467.6666666666667

Domain

Note=Ig-like V-type

Tgene

CD300LF

chr17:74719853

chr17:72700955

ENST00000464910

20_126

17.333333333333332

294.0

Domain

Note=Ig-like V-type

Tgene

CD300LF

chr17:74719853

chr17:72700955

ENST00000469092

20_126

17.333333333333332

442.0

Domain

Note=Ig-like V-type

Tgene

CD300LF

chr17:74719853

chr17:72700955

ENST00000581500

20_126

17.333333333333332

240.0

Domain

Note=Ig-like V-type

Tgene

CD300LF

chr17:74719853

chr17:72700955

ENST00000301573

178_290

14.333333333333334

444.6666666666667

Topological domain

Cytoplasmic

Tgene

CD300LF

chr17:74719853

chr17:72700955

ENST00000301573

20_156

14.333333333333334

444.6666666666667

Topological domain

Extracellular

Tgene

CD300LF

chr17:74719853

chr17:72700955

ENST00000326165

178_290

14.333333333333334

291.0

Topological domain

Cytoplasmic

Tgene

CD300LF

chr17:74719853

chr17:72700955

ENST00000326165

20_156

14.333333333333334

291.0

Topological domain

Extracellular

Tgene

CD300LF

chr17:74719853

chr17:72700955

ENST00000343125

178_290

17.333333333333332

422.6666666666667

Topological domain

Cytoplasmic

Tgene

CD300LF

chr17:74719853

chr17:72700955

ENST00000343125

20_156

17.333333333333332

422.6666666666667

Topological domain

Extracellular

Tgene

CD300LF

chr17:74719853

chr17:72700955

ENST00000361254

178_290

17.333333333333332

467.6666666666667

Topological domain

Cytoplasmic

Tgene

CD300LF

chr17:74719853

chr17:72700955

ENST00000361254

20_156

17.333333333333332

467.6666666666667

Topological domain

Extracellular

Tgene

CD300LF

chr17:74719853

chr17:72700955

ENST00000464910

178_290

17.333333333333332

294.0

Topological domain

Cytoplasmic

Tgene

CD300LF

chr17:74719853

chr17:72700955

ENST00000464910

20_156

17.333333333333332

294.0

Topological domain

Extracellular

Tgene

CD300LF

chr17:74719853

chr17:72700955

ENST00000469092

178_290

17.333333333333332

442.0

Topological domain

Cytoplasmic

Tgene

CD300LF

chr17:74719853

chr17:72700955

ENST00000469092

20_156

17.333333333333332

442.0

Topological domain

Extracellular

Tgene

CD300LF

chr17:74719853

chr17:72700955

ENST00000581500

178_290

17.333333333333332

240.0

Topological domain

Cytoplasmic

Tgene

CD300LF

chr17:74719853

chr17:72700955

ENST00000581500

20_156

17.333333333333332

240.0

Topological domain

Extracellular

Tgene

CD300LF

chr17:74719853

chr17:72700955

ENST00000301573

157_177

14.333333333333334

444.6666666666667

Transmembrane

Helical

Tgene

CD300LF

chr17:74719853

chr17:72700955

ENST00000326165

157_177

14.333333333333334

291.0

Transmembrane

Helical

Tgene

CD300LF

chr17:74719853

chr17:72700955

ENST00000343125

157_177

17.333333333333332

422.6666666666667

Transmembrane

Helical

Tgene

CD300LF

chr17:74719853

chr17:72700955

ENST00000361254

157_177

17.333333333333332

467.6666666666667

Transmembrane

Helical

Tgene

CD300LF

chr17:74719853

chr17:72700955

ENST00000464910

157_177

17.333333333333332

294.0

Transmembrane

Helical

Tgene

CD300LF

chr17:74719853

chr17:72700955

ENST00000469092

157_177

17.333333333333332

442.0

Transmembrane

Helical

Tgene

CD300LF

chr17:74719853

chr17:72700955

ENST00000581500

157_177

17.333333333333332

240.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

JMJD6

chr17:74719853

chr17:72700955

ENST00000397625

340_365

268.3333333333333

404.0

Compositional bias

Note=Ser-rich

Hgene

JMJD6

chr17:74719853

chr17:72700955

ENST00000445478

340_365

268.3333333333333

415.0

Compositional bias

Note=Ser-rich

Hgene

JMJD6

chr17:74719853

chr17:72700955

ENST00000397625

141_305

268.3333333333333

404.0

Domain

JmjC

Hgene

JMJD6

chr17:74719853

chr17:72700955

ENST00000445478

141_305

268.3333333333333

415.0

Domain

JmjC

Hgene

JMJD6

chr17:74719853

chr17:72700955

ENST00000397625

373_378

268.3333333333333

404.0

Motif

Nuclear localization signal 5

Hgene

JMJD6

chr17:74719853

chr17:72700955

ENST00000445478

373_378

268.3333333333333

415.0

Motif

Nuclear localization signal 5

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
JMJD6
CD300LF

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to JMJD6-CD300LF

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to JMJD6-CD300LF

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source