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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:KANSL1L-ERBB4

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: KANSL1L-ERBB4
	FusionPDB ID: 41133
	FusionGDB2.0 ID: 41133
		Hgene	Tgene
	Gene symbol	KANSL1L	ERBB4
	Gene ID	151050	2066
	Gene name	KAT8 regulatory NSL complex subunit 1 like	erb-b2 receptor tyrosine kinase 4
	Synonyms	C2orf67\|MSL1v2	ALS19\|HER4\|p180erbB4
	Cytomap	2q34	2q34
	Type of gene	protein-coding	protein-coding
	Description	KAT8 regulatory NSL complex subunit 1-like proteinmale-specific lethal 1 homolog	receptor tyrosine-protein kinase erbB-4avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4human epidermal growth factor receptor 4proto-oncogene-like protein c-ErbB-4tyrosine kinase-type cell surface receptor HER4v-erb-a erythroblastic
	Modification date	20200313	20200327
	UniProtAcc	A0AUZ9	Q15303
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000281772, ENST00000418791, ENST00000452086, ENST00000457374, ENST00000429908,	ENST00000484474, ENST00000342788, ENST00000402597, ENST00000436443,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	7 X 7 X 4=196	18 X 16 X 8=2304
	# samples	7	17
	** MAII score	log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(17/2304*10)=-3.76053406530461 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: KANSL1L [Title/Abstract] AND ERBB4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	KANSL1L(210993755)-ERBB4(212495319), # samples:1
Anticipated loss of major functional domain due to fusion event.	KANSL1L-ERBB4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KANSL1L-ERBB4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KANSL1L-ERBB4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KANSL1L-ERBB4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KANSL1L-ERBB4 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. KANSL1L-ERBB4 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. KANSL1L-ERBB4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. KANSL1L-ERBB4 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. KANSL1L-ERBB4 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ERBB4	GO:0007165	signal transduction	10572067
Tgene	ERBB4	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	10353604\|18334220
Tgene	ERBB4	GO:0016477	cell migration	9135143
Tgene	ERBB4	GO:0018108	peptidyl-tyrosine phosphorylation	18334220
Tgene	ERBB4	GO:0046777	protein autophosphorylation	18334220

Fusion gene breakpoints across KANSL1L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ERBB4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-D8-A27M-01A	KANSL1L	chr2	210993755	-	ERBB4	chr2	212495319	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000281772	KANSL1L	chr2	210993755	-	ENST00000436443	ERBB4	chr2	212495319	-	11321	1494	1501	3426	641
ENST00000281772	KANSL1L	chr2	210993755	-	ENST00000342788	ERBB4	chr2	212495319	-	11369	1494	1501	3474	657
ENST00000281772	KANSL1L	chr2	210993755	-	ENST00000402597	ERBB4	chr2	212495319	-	3475	1494	1501	3474	658
ENST00000418791	KANSL1L	chr2	210993755	-	ENST00000436443	ERBB4	chr2	212495319	-	11265	1438	1445	3370	641
ENST00000418791	KANSL1L	chr2	210993755	-	ENST00000342788	ERBB4	chr2	212495319	-	11313	1438	1445	3418	657
ENST00000418791	KANSL1L	chr2	210993755	-	ENST00000402597	ERBB4	chr2	212495319	-	3419	1438	1445	3418	658
ENST00000452086	KANSL1L	chr2	210993755	-	ENST00000436443	ERBB4	chr2	212495319	-	11265	1438	1445	3370	641
ENST00000452086	KANSL1L	chr2	210993755	-	ENST00000342788	ERBB4	chr2	212495319	-	11313	1438	1445	3418	657
ENST00000452086	KANSL1L	chr2	210993755	-	ENST00000402597	ERBB4	chr2	212495319	-	3419	1438	1445	3418	658

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000281772	ENST00000436443	KANSL1L	chr2	210993755	-	ERBB4	chr2	212495319	-	0.000178649	0.99982136
ENST00000281772	ENST00000342788	KANSL1L	chr2	210993755	-	ERBB4	chr2	212495319	-	0.000179412	0.99982065
ENST00000281772	ENST00000402597	KANSL1L	chr2	210993755	-	ERBB4	chr2	212495319	-	0.001344294	0.9986557
ENST00000418791	ENST00000436443	KANSL1L	chr2	210993755	-	ERBB4	chr2	212495319	-	0.000176571	0.9998235
ENST00000418791	ENST00000342788	KANSL1L	chr2	210993755	-	ERBB4	chr2	212495319	-	0.000176957	0.99982303
ENST00000418791	ENST00000402597	KANSL1L	chr2	210993755	-	ERBB4	chr2	212495319	-	0.001262129	0.9987379
ENST00000452086	ENST00000436443	KANSL1L	chr2	210993755	-	ERBB4	chr2	212495319	-	0.000176571	0.9998235
ENST00000452086	ENST00000342788	KANSL1L	chr2	210993755	-	ERBB4	chr2	212495319	-	0.000176957	0.99982303
ENST00000452086	ENST00000402597	KANSL1L	chr2	210993755	-	ERBB4	chr2	212495319	-	0.001262129	0.9987379

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>41133_41133_1_KANSL1L-ERBB4_KANSL1L_chr2_210993755_ENST00000281772_ERBB4_chr2_212495319_ENST00000342788_length(amino acids)=657AA_BP=
MIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEG
ETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGM
MYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPY
DGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEE
DLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEI
FDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNA
SNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAEN

--------------------------------------------------------------

>41133_41133_2_KANSL1L-ERBB4_KANSL1L_chr2_210993755_ENST00000281772_ERBB4_chr2_212495319_ENST00000402597_length(amino acids)=658AA_BP=
MIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEG
ETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGM
MYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPY
DGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEE
DLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEI
FDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNA
SNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAEN

--------------------------------------------------------------

>41133_41133_3_KANSL1L-ERBB4_KANSL1L_chr2_210993755_ENST00000281772_ERBB4_chr2_212495319_ENST00000436443_length(amino acids)=641AA_BP=
MIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEG
ETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGM
MYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPY
DGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEE
DLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAP
HVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPL
YLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLP

--------------------------------------------------------------

>41133_41133_4_KANSL1L-ERBB4_KANSL1L_chr2_210993755_ENST00000418791_ERBB4_chr2_212495319_ENST00000342788_length(amino acids)=657AA_BP=
MIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEG
ETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGM
MYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPY
DGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEE
DLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEI
FDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNA
SNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAEN

--------------------------------------------------------------

>41133_41133_5_KANSL1L-ERBB4_KANSL1L_chr2_210993755_ENST00000418791_ERBB4_chr2_212495319_ENST00000402597_length(amino acids)=658AA_BP=
MIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEG
ETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGM
MYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPY
DGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEE
DLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEI
FDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNA
SNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAEN

--------------------------------------------------------------

>41133_41133_6_KANSL1L-ERBB4_KANSL1L_chr2_210993755_ENST00000418791_ERBB4_chr2_212495319_ENST00000436443_length(amino acids)=641AA_BP=
MIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEG
ETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGM
MYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPY
DGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEE
DLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAP
HVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPL
YLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLP

--------------------------------------------------------------

>41133_41133_7_KANSL1L-ERBB4_KANSL1L_chr2_210993755_ENST00000452086_ERBB4_chr2_212495319_ENST00000342788_length(amino acids)=657AA_BP=
MIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEG
ETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGM
MYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPY
DGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEE
DLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEI
FDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNA
SNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAEN

--------------------------------------------------------------

>41133_41133_8_KANSL1L-ERBB4_KANSL1L_chr2_210993755_ENST00000452086_ERBB4_chr2_212495319_ENST00000402597_length(amino acids)=658AA_BP=
MIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEG
ETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGM
MYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPY
DGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEE
DLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEI
FDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNA
SNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAEN

--------------------------------------------------------------

>41133_41133_9_KANSL1L-ERBB4_KANSL1L_chr2_210993755_ENST00000452086_ERBB4_chr2_212495319_ENST00000436443_length(amino acids)=641AA_BP=
MIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEG
ETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGM
MYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPY
DGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEE
DLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAP
HVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPL
YLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLP

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:210993755/chr2:212495319)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KANSL1L A0AUZ9	ERBB4 Q15303
	FUNCTION: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. {ECO:0000269\|PubMed:10348342, ECO:0000269\|PubMed:10353604, ECO:0000269\|PubMed:10358079, ECO:0000269\|PubMed:10722704, ECO:0000269\|PubMed:10867024, ECO:0000269\|PubMed:11178955, ECO:0000269\|PubMed:11390655, ECO:0000269\|PubMed:12807903, ECO:0000269\|PubMed:15534001, ECO:0000269\|PubMed:15746097, ECO:0000269\|PubMed:16251361, ECO:0000269\|PubMed:16778220, ECO:0000269\|PubMed:16837552, ECO:0000269\|PubMed:17486069, ECO:0000269\|PubMed:17638867, ECO:0000269\|PubMed:19098003, ECO:0000269\|PubMed:20858735, ECO:0000269\|PubMed:8383326, ECO:0000269\|PubMed:8617750, ECO:0000269\|PubMed:9135143, ECO:0000269\|PubMed:9168115, ECO:0000269\|PubMed:9334263}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000342788

718_985

648.6666666666666

1309.0

Domain

Protein kinase

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000402597

718_985

638.6666666666666

1299.0

Domain

Protein kinase

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000436443

718_985

648.6666666666666

1293.0

Domain

Protein kinase

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000342788

1032_1035

648.6666666666666

1309.0

Motif

Note=PPxY motif 1

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000342788

1053_1056

648.6666666666666

1309.0

Motif

Note=PPxY motif 2

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000342788

1298_1301

648.6666666666666

1309.0

Motif

Note=PPxY motif 3

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000342788

1306_1308

648.6666666666666

1309.0

Motif

Note=PDZ-binding

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000342788

676_684

648.6666666666666

1309.0

Motif

Note=Nuclear localization signal

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000402597

1032_1035

638.6666666666666

1299.0

Motif

Note=PPxY motif 1

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000402597

1053_1056

638.6666666666666

1299.0

Motif

Note=PPxY motif 2

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000402597

1298_1301

638.6666666666666

1299.0

Motif

Note=PPxY motif 3

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000402597

1306_1308

638.6666666666666

1299.0

Motif

Note=PDZ-binding

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000402597

676_684

638.6666666666666

1299.0

Motif

Note=Nuclear localization signal

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000436443

1032_1035

648.6666666666666

1293.0

Motif

Note=PPxY motif 1

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000436443

1053_1056

648.6666666666666

1293.0

Motif

Note=PPxY motif 2

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000436443

1298_1301

648.6666666666666

1293.0

Motif

Note=PPxY motif 3

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000436443

1306_1308

648.6666666666666

1293.0

Motif

Note=PDZ-binding

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000436443

676_684

648.6666666666666

1293.0

Motif

Note=Nuclear localization signal

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000342788

724_732

648.6666666666666

1309.0

Nucleotide binding

ATP

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000342788

797_799

648.6666666666666

1309.0

Nucleotide binding

ATP

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000342788

843_848

648.6666666666666

1309.0

Nucleotide binding

ATP

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000402597

724_732

638.6666666666666

1299.0

Nucleotide binding

ATP

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000402597

797_799

638.6666666666666

1299.0

Nucleotide binding

ATP

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000402597

843_848

638.6666666666666

1299.0

Nucleotide binding

ATP

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000436443

724_732

648.6666666666666

1293.0

Nucleotide binding

ATP

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000436443

797_799

648.6666666666666

1293.0

Nucleotide binding

ATP

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000436443

843_848

648.6666666666666

1293.0

Nucleotide binding

ATP

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000342788

676_1308

648.6666666666666

1309.0

Topological domain

Cytoplasmic

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000402597

676_1308

638.6666666666666

1299.0

Topological domain

Cytoplasmic

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000436443

676_1308

648.6666666666666

1293.0

Topological domain

Cytoplasmic

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000342788

652_675

648.6666666666666

1309.0

Transmembrane

Helical

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000402597

652_675

638.6666666666666

1299.0

Transmembrane

Helical

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000436443

652_675

648.6666666666666

1293.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000342788

186_334

648.6666666666666

1309.0

Compositional bias

Note=Cys-rich

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000342788

496_633

648.6666666666666

1309.0

Compositional bias

Note=Cys-rich

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000402597

186_334

638.6666666666666

1299.0

Compositional bias

Note=Cys-rich

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000402597

496_633

638.6666666666666

1299.0

Compositional bias

Note=Cys-rich

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000436443

186_334

648.6666666666666

1293.0

Compositional bias

Note=Cys-rich

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000436443

496_633

648.6666666666666

1293.0

Compositional bias

Note=Cys-rich

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000342788

26_651

648.6666666666666

1309.0

Topological domain

Extracellular

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000402597

26_651

638.6666666666666

1299.0

Topological domain

Extracellular

Tgene

ERBB4

chr2:210993755

chr2:212495319

ENST00000436443

26_651

648.6666666666666

1293.0

Topological domain

Extracellular

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
KANSL1L
ERBB4

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to KANSL1L-ERBB4

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to KANSL1L-ERBB4

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	ERBB4	C0005586	Bipolar Disorder	5	PSYGENET
Tgene	ERBB4	C0036341	Schizophrenia	4	PSYGENET
Tgene	ERBB4	C0004238	Atrial Fibrillation	2	CTD_human
Tgene	ERBB4	C0235480	Paroxysmal atrial fibrillation	2	CTD_human
Tgene	ERBB4	C2585653	Persistent atrial fibrillation	2	CTD_human
Tgene	ERBB4	C3468561	familial atrial fibrillation	2	CTD_human
Tgene	ERBB4	C0002736	Amyotrophic Lateral Sclerosis	1	ORPHANET
Tgene	ERBB4	C0007114	Malignant neoplasm of skin	1	CTD_human
Tgene	ERBB4	C0016978	gallbladder neoplasm	1	CTD_human
Tgene	ERBB4	C0025202	melanoma	1	CGI;CTD_human
Tgene	ERBB4	C0037286	Skin Neoplasms	1	CTD_human
Tgene	ERBB4	C0153452	Malignant neoplasm of gallbladder	1	CTD_human
Tgene	ERBB4	C3715155	AMYOTROPHIC LATERAL SCLEROSIS 19	1	CTD_human;GENOMICS_ENGLAND;UNIPROT