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Fusion Protein:KAT2B-KANSL1 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: KAT2B-KANSL1 | FusionPDB ID: 41186 | FusionGDB2.0 ID: 41186 | Hgene | Tgene | Gene symbol | KAT2B | KANSL1 | Gene ID | 8850 | 284058 |
| Gene name | lysine acetyltransferase 2B | KAT8 regulatory NSL complex subunit 1 | |
| Synonyms | CAF|P/CAF|PCAF | CENP-36|KDVS|KIAA1267|MSL1v1|NSL1|hMSL1v1 | |
| Cytomap | 3p24.3 | 17q21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | histone acetyltransferase KAT2BCREBBP-associated factorK(lysine) acetyltransferase 2Bhistone acetylase PCAFhistone acetyltransferase PCAFp300/CBP-associated factorspermidine acetyltransferase KAT2B | KAT8 regulatory NSL complex subunit 1MLL1/MLL complex subunit KANSL1MSL1 homolog 1NSL complex protein NSL1centromere protein 36male-specific lethal 1 homolognon-specific lethal 1 homolog | |
| Modification date | 20200313 | 20200327 | |
| UniProtAcc | Q92831 | A0AUZ9 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000426228, ENST00000263754, | ENST00000262419, ENST00000432791, ENST00000572904, ENST00000574590, ENST00000575318, ENST00000393476, ENST00000576248, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 4 X 4 X 2=32 | 17 X 18 X 11=3366 |
| # samples | 4 | 28 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(28/3366*10)=-3.58753644438498 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: KAT2B [Title/Abstract] AND KANSL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | KAT2B(20136900)-KANSL1(44145033), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | KAT2B-KANSL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KAT2B-KANSL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KAT2B-KANSL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KAT2B-KANSL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KAT2B | GO:0006338 | chromatin remodeling | 17707232 |
| Hgene | KAT2B | GO:0006473 | protein acetylation | 15273251|26867678 |
| Hgene | KAT2B | GO:0008285 | negative regulation of cell proliferation | 8684459 |
| Hgene | KAT2B | GO:0010835 | regulation of protein ADP-ribosylation | 19470756 |
| Hgene | KAT2B | GO:0018076 | N-terminal peptidyl-lysine acetylation | 12435739 |
| Hgene | KAT2B | GO:0018393 | internal peptidyl-lysine acetylation | 23932781|27796307|29174768 |
| Hgene | KAT2B | GO:0018394 | peptidyl-lysine acetylation | 19303849|19470756 |
| Hgene | KAT2B | GO:0032869 | cellular response to insulin stimulus | 19303849 |
| Hgene | KAT2B | GO:0043966 | histone H3 acetylation | 18838386 |
| Hgene | KAT2B | GO:0045944 | positive regulation of transcription by RNA polymerase II | 19470756 |
| Hgene | KAT2B | GO:0046600 | negative regulation of centriole replication | 27796307 |
| Hgene | KAT2B | GO:2000233 | negative regulation of rRNA processing | 26867678 |
| Tgene | KANSL1 | GO:0043981 | histone H4-K5 acetylation | 20018852 |
| Tgene | KANSL1 | GO:0043982 | histone H4-K8 acetylation | 20018852 |
| Tgene | KANSL1 | GO:0043984 | histone H4-K16 acetylation | 20018852 |
| Fusion gene breakpoints across KAT2B (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across KANSL1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | Non-Cancer | ERR315398 | KAT2B | chr3 | 20136900 | + | KANSL1 | chr17 | 44145033 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000263754 | KAT2B | chr3 | 20136900 | + | ENST00000574590 | KANSL1 | chr17 | 44145033 | - | 4376 | 1031 | 455 | 2815 | 786 |
| ENST00000263754 | KAT2B | chr3 | 20136900 | + | ENST00000575318 | KANSL1 | chr17 | 44145033 | - | 4175 | 1031 | 455 | 2623 | 722 |
| ENST00000263754 | KAT2B | chr3 | 20136900 | + | ENST00000572904 | KANSL1 | chr17 | 44145033 | - | 4339 | 1031 | 455 | 2815 | 786 |
| ENST00000263754 | KAT2B | chr3 | 20136900 | + | ENST00000262419 | KANSL1 | chr17 | 44145033 | - | 4336 | 1031 | 455 | 2815 | 786 |
| ENST00000263754 | KAT2B | chr3 | 20136900 | + | ENST00000432791 | KANSL1 | chr17 | 44145033 | - | 4324 | 1031 | 455 | 2815 | 786 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000263754 | ENST00000574590 | KAT2B | chr3 | 20136900 | + | KANSL1 | chr17 | 44145033 | - | 0.007110466 | 0.9928895 |
| ENST00000263754 | ENST00000575318 | KAT2B | chr3 | 20136900 | + | KANSL1 | chr17 | 44145033 | - | 0.010896575 | 0.98910344 |
| ENST00000263754 | ENST00000572904 | KAT2B | chr3 | 20136900 | + | KANSL1 | chr17 | 44145033 | - | 0.007892 | 0.9921079 |
| ENST00000263754 | ENST00000262419 | KAT2B | chr3 | 20136900 | + | KANSL1 | chr17 | 44145033 | - | 0.007859941 | 0.9921401 |
| ENST00000263754 | ENST00000432791 | KAT2B | chr3 | 20136900 | + | KANSL1 | chr17 | 44145033 | - | 0.008444278 | 0.99155575 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >41186_41186_1_KAT2B-KANSL1_KAT2B_chr3_20136900_ENST00000263754_KANSL1_chr17_44145033_ENST00000262419_length(amino acids)=786AA_BP=192 MSEAGGAGPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAAAAGGSGACGPATAVAAAGTAEGPGGGGSARIAVKKAQLRSAPRAKK LEKLGVYSACKAEESCKCNGWKNPNPSPTPPRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEED ADTKQVYFYLFKIESVSQPLENHGARIIGHISESLSTKSCGALRPVNGVINTLQPVLADHIPGDSSDAEEQLHKKQRLNLVSSSSDGTCV AARTRPVLSCKKRRLVRPNSIVPLSKKVHRNSTIRPGCDVNPSCALCGSGSINTMPPEIHYEAPLLERLSQLDSCVHPVLAFPDDVPTSL HFQSMLKSQWQNKPFDKIKPPKKLSLKHRAPMPGSLPDSARKDRHKLVSSFLTTAKLSHHQTRPDRTHRQHLDDVGAVPMVERVTAPKAE RLLNPPPPVHDPNHSKMRLRDHSSERSEVLKHHTDMSSSSYLAATHHPPHSPLVRQLSTSSDSPAPASSSSQVTASTSQQPVRRRRGESS FDINNIVIPMSVAATTRVEKLQYKEILTPSWREVDLQSLKGSPDEENEEIEDLSDAAFAALHAKCEEMERARWLWTTSVPPQRRGSRSYR SSDGRTTPQLGSANPSTPQPASPDVSSSHSLSEYSHGQSPRSPISPELHSAPLTPVARDTPRHLASEDTRCSTPELGLDEQSVQPWERRT -------------------------------------------------------------- >41186_41186_2_KAT2B-KANSL1_KAT2B_chr3_20136900_ENST00000263754_KANSL1_chr17_44145033_ENST00000432791_length(amino acids)=786AA_BP=192 MSEAGGAGPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAAAAGGSGACGPATAVAAAGTAEGPGGGGSARIAVKKAQLRSAPRAKK LEKLGVYSACKAEESCKCNGWKNPNPSPTPPRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEED ADTKQVYFYLFKIESVSQPLENHGARIIGHISESLSTKSCGALRPVNGVINTLQPVLADHIPGDSSDAEEQLHKKQRLNLVSSSSDGTCV AARTRPVLSCKKRRLVRPNSIVPLSKKVHRNSTIRPGCDVNPSCALCGSGSINTMPPEIHYEAPLLERLSQLDSCVHPVLAFPDDVPTSL HFQSMLKSQWQNKPFDKIKPPKKLSLKHRAPMPGSLPDSARKDRHKLVSSFLTTAKLSHHQTRPDRTHRQHLDDVGAVPMVERVTAPKAE RLLNPPPPVHDPNHSKMRLRDHSSERSEVLKHHTDMSSSSYLAATHHPPHSPLVRQLSTSSDSPAPASSSSQVTASTSQQPVRRRRGESS FDINNIVIPMSVAATTRVEKLQYKEILTPSWREVDLQSLKGSPDEENEEIEDLSDAAFAALHAKCEEMERARWLWTTSVPPQRRGSRSYR SSDGRTTPQLGSANPSTPQPASPDVSSSHSLSEYSHGQSPRSPISPELHSAPLTPVARDTPRHLASEDTRCSTPELGLDEQSVQPWERRT -------------------------------------------------------------- >41186_41186_3_KAT2B-KANSL1_KAT2B_chr3_20136900_ENST00000263754_KANSL1_chr17_44145033_ENST00000572904_length(amino acids)=786AA_BP=192 MSEAGGAGPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAAAAGGSGACGPATAVAAAGTAEGPGGGGSARIAVKKAQLRSAPRAKK LEKLGVYSACKAEESCKCNGWKNPNPSPTPPRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEED ADTKQVYFYLFKIESVSQPLENHGARIIGHISESLSTKSCGALRPVNGVINTLQPVLADHIPGDSSDAEEQLHKKQRLNLVSSSSDGTCV AARTRPVLSCKKRRLVRPNSIVPLSKKVHRNSTIRPGCDVNPSCALCGSGSINTMPPEIHYEAPLLERLSQLDSCVHPVLAFPDDVPTSL HFQSMLKSQWQNKPFDKIKPPKKLSLKHRAPMPGSLPDSARKDRHKLVSSFLTTAKLSHHQTRPDRTHRQHLDDVGAVPMVERVTAPKAE RLLNPPPPVHDPNHSKMRLRDHSSERSEVLKHHTDMSSSSYLAATHHPPHSPLVRQLSTSSDSPAPASSSSQVTASTSQQPVRRRRGESS FDINNIVIPMSVAATTRVEKLQYKEILTPSWREVDLQSLKGSPDEENEEIEDLSDAAFAALHAKCEEMERARWLWTTSVPPQRRGSRSYR SSDGRTTPQLGSANPSTPQPASPDVSSSHSLSEYSHGQSPRSPISPELHSAPLTPVARDTPRHLASEDTRCSTPELGLDEQSVQPWERRT -------------------------------------------------------------- >41186_41186_4_KAT2B-KANSL1_KAT2B_chr3_20136900_ENST00000263754_KANSL1_chr17_44145033_ENST00000574590_length(amino acids)=786AA_BP=192 MSEAGGAGPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAAAAGGSGACGPATAVAAAGTAEGPGGGGSARIAVKKAQLRSAPRAKK LEKLGVYSACKAEESCKCNGWKNPNPSPTPPRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEED ADTKQVYFYLFKIESVSQPLENHGARIIGHISESLSTKSCGALRPVNGVINTLQPVLADHIPGDSSDAEEQLHKKQRLNLVSSSSDGTCV AARTRPVLSCKKRRLVRPNSIVPLSKKVHRNSTIRPGCDVNPSCALCGSGSINTMPPEIHYEAPLLERLSQLDSCVHPVLAFPDDVPTSL HFQSMLKSQWQNKPFDKIKPPKKLSLKHRAPMPGSLPDSARKDRHKLVSSFLTTAKLSHHQTRPDRTHRQHLDDVGAVPMVERVTAPKAE RLLNPPPPVHDPNHSKMRLRDHSSERSEVLKHHTDMSSSSYLAATHHPPHSPLVRQLSTSSDSPAPASSSSQVTASTSQQPVRRRRGESS FDINNIVIPMSVAATTRVEKLQYKEILTPSWREVDLQSLKGSPDEENEEIEDLSDAAFAALHAKCEEMERARWLWTTSVPPQRRGSRSYR SSDGRTTPQLGSANPSTPQPASPDVSSSHSLSEYSHGQSPRSPISPELHSAPLTPVARDTPRHLASEDTRCSTPELGLDEQSVQPWERRT -------------------------------------------------------------- >41186_41186_5_KAT2B-KANSL1_KAT2B_chr3_20136900_ENST00000263754_KANSL1_chr17_44145033_ENST00000575318_length(amino acids)=722AA_BP=192 MSEAGGAGPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAAAAGGSGACGPATAVAAAGTAEGPGGGGSARIAVKKAQLRSAPRAKK LEKLGVYSACKAEESCKCNGWKNPNPSPTPPRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEED ADTKQVYFYLFKIESVSQPLENHGARIIGHISESLSTKSCGALRPVNGVINTLQPVLADHIPGDSSDAEEQLHKKQRLNLVSSSSDGTCV AARTRPVLSCKKRRLVRPNSIVPLSKKVHRNSTIRPGCDVNPSCALCGSGSINTMPPEIHYEAPLLERLSQLDSCVHPVLAFPDDVPTSL HFQSMLKSQWQNKPFDKIKPPKKLSLKHRAPMPGSLPDSARKDRHKLVSSFLTTAMLKHHTDMSSSSYLAATHHPPHSPLVRQLSTSSDS PAPASSSSQVTASTSQPVRRRRGESSFDINNIVIPMSVAATTRVEKLQYKEILTPSWREVDLQSLKGSPDEENEEIEDLSDAAFAALHAK CEEMERARWLWTTSVPPQRRGSRSYRSSDGRTTPQLGSANPSTPQPASPDVSSSHSLSEYSHGQSPRSPISPELHSAPLTPVARDTPRHL ASEDTRCSTPELGLDEQSVQPWERRTFPLAHSPQAECEDQLDAQERAARCTRRTSGSKTGRETEAAPTSPPIVPLKSRHLVAAATAQRPT -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:20136900/chr17:44145033) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KAT2B | KANSL1 |
| FUNCTION: Functions as a histone acetyltransferase (HAT) to promote transcriptional activation (PubMed:8945521). Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles (PubMed:8945521). Also acetylates non-histone proteins, such as ACLY, PLK4, RRP9/U3-55K and TBX5 (PubMed:9707565, PubMed:10675335, PubMed:27796307, PubMed:23932781, PubMed:26867678, PubMed:29174768). Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A (PubMed:8684459). Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (PubMed:14645221). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307). Acetylates RRP9/U3-55K, a core subunit of the U3 snoRNP complex, impairing pre-rRNA processing (PubMed:26867678). Also acetylates spermidine (PubMed:27389534). {ECO:0000269|PubMed:10675335, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:26867678, ECO:0000269|PubMed:27389534, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:29174768, ECO:0000269|PubMed:8684459, ECO:0000269|PubMed:8945521, ECO:0000269|PubMed:9707565}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. {ECO:0000269|PubMed:12486002}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | KANSL1 | chr3:20136900 | chr17:44145033 | ENST00000262419 | 3 | 15 | 850_882 | 511.0 | 1106.0 | Region | Note=Required for activation of KAT8 histone acetyltransferase activity | |
| Tgene | KANSL1 | chr3:20136900 | chr17:44145033 | ENST00000432791 | 2 | 14 | 850_882 | 511.0 | 1106.0 | Region | Note=Required for activation of KAT8 histone acetyltransferase activity | |
| Tgene | KANSL1 | chr3:20136900 | chr17:44145033 | ENST00000572904 | 3 | 15 | 850_882 | 511.0 | 1106.0 | Region | Note=Required for activation of KAT8 histone acetyltransferase activity | |
| Tgene | KANSL1 | chr3:20136900 | chr17:44145033 | ENST00000574590 | 3 | 15 | 850_882 | 511.0 | 1106.0 | Region | Note=Required for activation of KAT8 histone acetyltransferase activity |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KAT2B | chr3:20136900 | chr17:44145033 | ENST00000263754 | + | 3 | 18 | 503_651 | 192.0 | 833.0 | Domain | N-acetyltransferase |
| Hgene | KAT2B | chr3:20136900 | chr17:44145033 | ENST00000263754 | + | 3 | 18 | 740_810 | 192.0 | 833.0 | Domain | Bromo |
| Hgene | KAT2B | chr3:20136900 | chr17:44145033 | ENST00000263754 | + | 3 | 18 | 574_576 | 192.0 | 833.0 | Region | Acetyl-CoA binding |
| Hgene | KAT2B | chr3:20136900 | chr17:44145033 | ENST00000263754 | + | 3 | 18 | 581_587 | 192.0 | 833.0 | Region | Acetyl-CoA binding |
| Hgene | KAT2B | chr3:20136900 | chr17:44145033 | ENST00000263754 | + | 3 | 18 | 612_615 | 192.0 | 833.0 | Region | Acetyl-CoA binding |
| Tgene | KANSL1 | chr3:20136900 | chr17:44145033 | ENST00000262419 | 3 | 15 | 283_314 | 511.0 | 1106.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | KANSL1 | chr3:20136900 | chr17:44145033 | ENST00000432791 | 2 | 14 | 283_314 | 511.0 | 1106.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | KANSL1 | chr3:20136900 | chr17:44145033 | ENST00000572904 | 3 | 15 | 283_314 | 511.0 | 1106.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | KANSL1 | chr3:20136900 | chr17:44145033 | ENST00000574590 | 3 | 15 | 283_314 | 511.0 | 1106.0 | Coiled coil | Ontology_term=ECO:0000255 |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| KAT2B | |
| KANSL1 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to KAT2B-KANSL1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to KAT2B-KANSL1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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