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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:KAT6A-CREBBP

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KAT6A-CREBBP
FusionPDB ID: 41201
FusionGDB2.0 ID: 41201
HgeneTgene
Gene symbol

KAT6A

CREBBP

Gene ID

7994

1387

Gene namelysine acetyltransferase 6ACREB binding protein
SynonymsARTHS|MOZ|MRD32|MYST-3|MYST3|RUNXBP2|ZC2HC6A|ZNF220CBP|KAT3A|MKHK1|RSTS|RSTS1
Cytomap

8p11.21

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionhistone acetyltransferase KAT6AK(lysine) acetyltransferase 6AMOZ, YBF2/SAS3, SAS2 and TIP60 protein 3MYST histone acetyltransferase (monocytic leukemia) 3histone acetyltransferase MYST3monocytic leukemia zinc finger proteinrunt-related transcriptionCREB-binding proteinhistone lysine acetyltransferase CREBBPprotein-lysine acetyltransferase CREBBP
Modification date2020031320200329
UniProtAcc

Q92794

Q92793

Ensembl transtripts involved in fusion geneENST idsENST00000265713, ENST00000396930, 
ENST00000406337, ENST00000485568, 
ENST00000262367, ENST00000382070, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score26 X 32 X 13=1081618 X 30 X 8=4320
# samples 4228
** MAII scorelog2(42/10816*10)=-4.68663391861606
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(28/4320*10)=-3.94753258010586
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: KAT6A [Title/Abstract] AND CREBBP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KAT6A(41794774)-CREBBP(3901010), # samples:1
KAT6A(41794961)-CREBBP(3843578), # samples:1
KAT6A(41794774)-CREBBP(3901011), # samples:1
KAT6A(41794774)-CREBBP(3860781), # samples:1
KAT6A(41793259)-CREBBP(3927186), # samples:1
KAT6A(41792414)-CREBBP(3926814), # samples:1
KAT6A(41793759)-CREBBP(3926060), # samples:1
KAT6A(41793848)-CREBBP(3907401), # samples:1
CREBBP(3929833)-KAT6A(41792385), # samples:1
CREBBP(3929833)-KAT6A(41792387), # samples:1
CREBBP(3927349)-KAT6A(41793271), # samples:1
CREBBP(3907404)-KAT6A(41793857), # samples:1
Anticipated loss of major functional domain due to fusion event.KAT6A-CREBBP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT6A-CREBBP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT6A-CREBBP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT6A-CREBBP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT6A-CREBBP seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
KAT6A-CREBBP seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KAT6A-CREBBP seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KAT6A-CREBBP seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KAT6A-CREBBP seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
KAT6A-CREBBP seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
KAT6A-CREBBP seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KAT6A-CREBBP seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KAT6A-CREBBP seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
CREBBP-KAT6A seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CREBBP-KAT6A seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
CREBBP-KAT6A seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
CREBBP-KAT6A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CREBBP-KAT6A seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
CREBBP-KAT6A seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
CREBBP-KAT6A seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
CREBBP-KAT6A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
CREBBP-KAT6A seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKAT6A

GO:0006473

protein acetylation

23431171

HgeneKAT6A

GO:0016573

histone acetylation

11742995|17925393

HgeneKAT6A

GO:0030099

myeloid cell differentiation

11742995

HgeneKAT6A

GO:0043966

histone H3 acetylation

16387653

HgeneKAT6A

GO:0045892

negative regulation of transcription, DNA-templated

11742995

HgeneKAT6A

GO:0045893

positive regulation of transcription, DNA-templated

11742995|11965546|18794358

TgeneCREBBP

GO:0000122

negative regulation of transcription by RNA polymerase II

21539536

TgeneCREBBP

GO:0006355

regulation of transcription, DNA-templated

12169688

TgeneCREBBP

GO:0006473

protein acetylation

15273251|24207024|24939902|28790157|30540930

TgeneCREBBP

GO:0016573

histone acetylation

11742995

TgeneCREBBP

GO:0018076

N-terminal peptidyl-lysine acetylation

12435739

TgeneCREBBP

GO:0034644

cellular response to UV

24939902

TgeneCREBBP

GO:0045893

positive regulation of transcription, DNA-templated

11742995

TgeneCREBBP

GO:1990258

histone glutamine methylation

30540930


check buttonFusion gene breakpoints across KAT6A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CREBBP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4acute myeloid leukemiaAJ251843KAT6Achr8

41794961

CREBBPchr16

3843578
ChimerDB4LAMLTCGA-AB-2910-03AKAT6Achr8

41794774

-CREBBPchr16

3901010

-
ChimerKB3..KAT6Achr8

41786996

CREBBPchr16

3860780

-
ChimerKB4..KAT6Achr8

41786996

CREBBPchr16

3860780

-
ChimerKB4..KAT6Achr8

41795086

-CREBBPchr16

41795086

-
ChiTaRS5.0N/AAJ251843KAT6Achr8

41794774

-CREBBPchr16

3901011

-
ChiTaRS5.0N/AAJ251844KAT6Achr8

41794774

-CREBBPchr16

3860781

-
ChiTaRS5.0N/AAJ315152KAT6Achr8

41793259

-CREBBPchr16

3927186

-
ChiTaRS5.0N/AAJ315154KAT6Achr8

41792414

-CREBBPchr16

3926814

-
ChiTaRS5.0N/AAJ315158KAT6Achr8

41793759

-CREBBPchr16

3926060

-
ChiTaRS5.0N/AAY442917KAT6Achr8

41793848

+CREBBPchr16

3907401

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000406337KAT6Achr841786996ENST00000262367CREBBPchr163860780-1843692419223157712182
ENST00000406337KAT6Achr841786996ENST00000382070CREBBPchr163860780-1583792419223156572144
ENST00000265713KAT6Achr841794774-ENST00000262367CREBBPchr163901010-136723764412110073531
ENST00000265713KAT6Achr841794774-ENST00000382070CREBBPchr163901010-110733764412108933493
ENST00000396930KAT6Achr841794774-ENST00000262367CREBBPchr163901010-138043896544111393531
ENST00000396930KAT6Achr841794774-ENST00000382070CREBBPchr163901010-112053896544110253493
ENST00000265713KAT6Achr841794774-ENST00000262367CREBBPchr163901011-136723764412110073531
ENST00000265713KAT6Achr841794774-ENST00000382070CREBBPchr163901011-110733764412108933493
ENST00000396930KAT6Achr841794774-ENST00000262367CREBBPchr163901011-138043896544111393531
ENST00000396930KAT6Achr841794774-ENST00000382070CREBBPchr163901011-112053896544110253493

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265713ENST00000262367KAT6Achr841794774-CREBBPchr163901010-0.0018739860.998126
ENST00000265713ENST00000382070KAT6Achr841794774-CREBBPchr163901010-0.0052430380.99475694
ENST00000396930ENST00000262367KAT6Achr841794774-CREBBPchr163901010-0.0021404890.99785954
ENST00000396930ENST00000382070KAT6Achr841794774-CREBBPchr163901010-0.0057999530.9942001
ENST00000265713ENST00000262367KAT6Achr841794774-CREBBPchr163901011-0.0018739860.998126
ENST00000265713ENST00000382070KAT6Achr841794774-CREBBPchr163901011-0.0052430380.99475694
ENST00000396930ENST00000262367KAT6Achr841794774-CREBBPchr163901011-0.0021404890.99785954
ENST00000396930ENST00000382070KAT6Achr841794774-CREBBPchr163901011-0.0057999530.9942001

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>41201_41201_1_KAT6A-CREBBP_KAT6A_chr8_41786996_ENST00000406337_CREBBP_chr16_3860780_ENST00000262367_length(amino acids)=2182AA_BP=4
MLSHFGMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEK
RKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKR
NQQTILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMN
IPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAA
LKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSL
PVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFP
SSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPST
PVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVAS
AETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGT
ASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLM
FNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVT
LGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLED
RVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVY
ISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYK
DIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSM
PNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQ
DRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANC
SLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQ
SLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQ
HLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPR
SISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVP
RPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGY
PPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHL
PGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSAL

--------------------------------------------------------------

>41201_41201_2_KAT6A-CREBBP_KAT6A_chr8_41786996_ENST00000406337_CREBBP_chr16_3860780_ENST00000382070_length(amino acids)=2144AA_BP=4
MLSHFGMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEK
RKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQAILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDP
SSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNS
GNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKI
YKIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMN
HSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGP
QASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTP
QPQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPR
SEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPES
LPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGY
CCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGR
KMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSR
FVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVT
GHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQ
EEEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPP
IVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSH
AHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCY
HAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSP
AGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQV
SGPVMPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMA
AFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQ
YREMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPG
LGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQ

--------------------------------------------------------------

>41201_41201_3_KAT6A-CREBBP_KAT6A_chr8_41794774_ENST00000265713_CREBBP_chr16_3901010_ENST00000262367_length(amino acids)=3531AA_BP=1117
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRD
QGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTS
DWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC
EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVG
YFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLT
GICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELE
ISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYG
ECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEE
EEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELF
PREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSS
INPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQT
GPGICMNANFNQTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQA
GGMAKMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKR
KLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRN
QQTILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNI
PAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAAL
KDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLP
VNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPS
SSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTP
VSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASA
ETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTA
SQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMF
NNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTL
GDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDR
VNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYI
SYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKD
IFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMP
NVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQD
RFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCS
LPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQS
LPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQH
LYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRS
ISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPR
PGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYP
PAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLP
GQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSALS

--------------------------------------------------------------

>41201_41201_4_KAT6A-CREBBP_KAT6A_chr8_41794774_ENST00000265713_CREBBP_chr16_3901010_ENST00000382070_length(amino acids)=3493AA_BP=1117
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRD
QGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTS
DWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC
EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVG
YFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLT
GICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELE
ISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYG
ECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEE
EEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELF
PREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSS
INPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQT
GPGICMNANFNQTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQA
GGMAKMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKR
KLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQAILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPS
SMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSG
NIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIY
KIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNH
SVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQ
ASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQ
PQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRS
EMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESL
PFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYC
CGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRK
MHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRF
VDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTG
HIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQE
EEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPI
VDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHA
HKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYH
AKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPA
GFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVS
GPVMPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAA
FIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQY
REMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGL
GADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQP

--------------------------------------------------------------

>41201_41201_5_KAT6A-CREBBP_KAT6A_chr8_41794774_ENST00000265713_CREBBP_chr16_3901011_ENST00000262367_length(amino acids)=3531AA_BP=1117
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRD
QGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTS
DWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC
EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVG
YFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLT
GICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELE
ISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYG
ECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEE
EEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELF
PREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSS
INPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQT
GPGICMNANFNQTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQA
GGMAKMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKR
KLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRN
QQTILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNI
PAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAAL
KDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLP
VNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPS
SSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTP
VSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASA
ETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTA
SQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMF
NNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTL
GDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDR
VNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYI
SYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKD
IFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMP
NVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQD
RFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCS
LPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQS
LPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQH
LYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRS
ISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPR
PGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYP
PAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLP
GQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSALS

--------------------------------------------------------------

>41201_41201_6_KAT6A-CREBBP_KAT6A_chr8_41794774_ENST00000265713_CREBBP_chr16_3901011_ENST00000382070_length(amino acids)=3493AA_BP=1117
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRD
QGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTS
DWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC
EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVG
YFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLT
GICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELE
ISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYG
ECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEE
EEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELF
PREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSS
INPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQT
GPGICMNANFNQTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQA
GGMAKMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKR
KLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQAILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPS
SMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSG
NIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIY
KIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNH
SVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQ
ASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQ
PQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRS
EMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESL
PFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYC
CGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRK
MHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRF
VDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTG
HIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQE
EEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPI
VDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHA
HKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYH
AKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPA
GFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVS
GPVMPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAA
FIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQY
REMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGL
GADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQP

--------------------------------------------------------------

>41201_41201_7_KAT6A-CREBBP_KAT6A_chr8_41794774_ENST00000396930_CREBBP_chr16_3901010_ENST00000262367_length(amino acids)=3531AA_BP=1117
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRD
QGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTS
DWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC
EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVG
YFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLT
GICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELE
ISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYG
ECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEE
EEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELF
PREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSS
INPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQT
GPGICMNANFNQTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQA
GGMAKMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKR
KLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRN
QQTILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNI
PAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAAL
KDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLP
VNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPS
SSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTP
VSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASA
ETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTA
SQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMF
NNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTL
GDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDR
VNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYI
SYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKD
IFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMP
NVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQD
RFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCS
LPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQS
LPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQH
LYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRS
ISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPR
PGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYP
PAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLP
GQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSALS

--------------------------------------------------------------

>41201_41201_8_KAT6A-CREBBP_KAT6A_chr8_41794774_ENST00000396930_CREBBP_chr16_3901010_ENST00000382070_length(amino acids)=3493AA_BP=1117
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRD
QGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTS
DWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC
EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVG
YFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLT
GICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELE
ISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYG
ECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEE
EEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELF
PREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSS
INPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQT
GPGICMNANFNQTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQA
GGMAKMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKR
KLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQAILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPS
SMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSG
NIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIY
KIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNH
SVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQ
ASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQ
PQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRS
EMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESL
PFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYC
CGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRK
MHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRF
VDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTG
HIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQE
EEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPI
VDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHA
HKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYH
AKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPA
GFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVS
GPVMPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAA
FIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQY
REMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGL
GADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQP

--------------------------------------------------------------

>41201_41201_9_KAT6A-CREBBP_KAT6A_chr8_41794774_ENST00000396930_CREBBP_chr16_3901011_ENST00000262367_length(amino acids)=3531AA_BP=1117
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRD
QGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTS
DWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC
EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVG
YFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLT
GICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELE
ISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYG
ECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEE
EEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELF
PREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSS
INPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQT
GPGICMNANFNQTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQA
GGMAKMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKR
KLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRN
QQTILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNI
PAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAAL
KDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLP
VNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPS
SSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTP
VSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASA
ETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTA
SQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMF
NNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTL
GDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDR
VNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYI
SYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKD
IFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMP
NVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQD
RFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCS
LPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQS
LPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQH
LYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRS
ISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPR
PGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYP
PAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLP
GQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSALS

--------------------------------------------------------------

>41201_41201_10_KAT6A-CREBBP_KAT6A_chr8_41794774_ENST00000396930_CREBBP_chr16_3901011_ENST00000382070_length(amino acids)=3493AA_BP=1117
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRD
QGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTS
DWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC
EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVG
YFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLT
GICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELE
ISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYG
ECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEE
EEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELF
PREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSS
INPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQT
GPGICMNANFNQTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQA
GGMAKMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKR
KLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQAILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPS
SMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSG
NIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIY
KIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNH
SVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQ
ASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQ
PQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRS
EMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESL
PFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYC
CGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRK
MHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRF
VDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTG
HIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQE
EEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPI
VDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHA
HKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYH
AKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPA
GFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVS
GPVMPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAA
FIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQY
REMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGL
GADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQP

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:41794774/chr16:3901010)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KAT6A

Q92794

CREBBP

Q92793

FUNCTION: Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. {ECO:0000269|PubMed:11742995, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:12771199, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17925393, ECO:0000269|PubMed:23431171}.FUNCTION: Acetylates histones, giving a specific tag for transcriptional activation (PubMed:24616510). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:9707565, PubMed:24207024, PubMed:28790157, PubMed:30540930). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:9707565}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

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* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKAT6Achr8:41794774chr16:3901010ENST00000265713-16171019_10261117.33333333333332005.0Compositional biasNote=Poly-Arg
HgeneKAT6Achr8:41794774chr16:3901010ENST00000265713-16171069_10781117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr16:3901010ENST00000265713-1617371_3791117.33333333333332005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41794774chr16:3901010ENST00000265713-1617788_8011117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr16:3901010ENST00000265713-1617989_9951117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr16:3901010ENST00000396930-17181019_10261117.33333333333332005.0Compositional biasNote=Poly-Arg
HgeneKAT6Achr8:41794774chr16:3901010ENST00000396930-17181069_10781117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr16:3901010ENST00000396930-1718371_3791117.33333333333332005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41794774chr16:3901010ENST00000396930-1718788_8011117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr16:3901010ENST00000396930-1718989_9951117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr16:3901010ENST00000406337-17181019_10261117.33333333333332005.0Compositional biasNote=Poly-Arg
HgeneKAT6Achr8:41794774chr16:3901010ENST00000406337-17181069_10781117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr16:3901010ENST00000406337-1718371_3791117.33333333333332005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41794774chr16:3901010ENST00000406337-1718788_8011117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr16:3901010ENST00000406337-1718989_9951117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr16:3901011ENST00000265713-16171019_10261117.33333333333332005.0Compositional biasNote=Poly-Arg
HgeneKAT6Achr8:41794774chr16:3901011ENST00000265713-16171069_10781117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr16:3901011ENST00000265713-1617371_3791117.33333333333332005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41794774chr16:3901011ENST00000265713-1617788_8011117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr16:3901011ENST00000265713-1617989_9951117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr16:3901011ENST00000396930-17181019_10261117.33333333333332005.0Compositional biasNote=Poly-Arg
HgeneKAT6Achr8:41794774chr16:3901011ENST00000396930-17181069_10781117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr16:3901011ENST00000396930-1718371_3791117.33333333333332005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41794774chr16:3901011ENST00000396930-1718788_8011117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr16:3901011ENST00000396930-1718989_9951117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr16:3901011ENST00000406337-17181019_10261117.33333333333332005.0Compositional biasNote=Poly-Arg
HgeneKAT6Achr8:41794774chr16:3901011ENST00000406337-17181069_10781117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr16:3901011ENST00000406337-1718371_3791117.33333333333332005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41794774chr16:3901011ENST00000406337-1718788_8011117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr16:3901011ENST00000406337-1718989_9951117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr16:3901010ENST00000265713-1617504_7781117.33333333333332005.0DomainMYST-type HAT
HgeneKAT6Achr8:41794774chr16:3901010ENST00000265713-161795_1711117.33333333333332005.0DomainH15
HgeneKAT6Achr8:41794774chr16:3901010ENST00000396930-1718504_7781117.33333333333332005.0DomainMYST-type HAT
HgeneKAT6Achr8:41794774chr16:3901010ENST00000396930-171895_1711117.33333333333332005.0DomainH15
HgeneKAT6Achr8:41794774chr16:3901010ENST00000406337-1718504_7781117.33333333333332005.0DomainMYST-type HAT
HgeneKAT6Achr8:41794774chr16:3901010ENST00000406337-171895_1711117.33333333333332005.0DomainH15
HgeneKAT6Achr8:41794774chr16:3901011ENST00000265713-1617504_7781117.33333333333332005.0DomainMYST-type HAT
HgeneKAT6Achr8:41794774chr16:3901011ENST00000265713-161795_1711117.33333333333332005.0DomainH15
HgeneKAT6Achr8:41794774chr16:3901011ENST00000396930-1718504_7781117.33333333333332005.0DomainMYST-type HAT
HgeneKAT6Achr8:41794774chr16:3901011ENST00000396930-171895_1711117.33333333333332005.0DomainH15
HgeneKAT6Achr8:41794774chr16:3901011ENST00000406337-1718504_7781117.33333333333332005.0DomainMYST-type HAT
HgeneKAT6Achr8:41794774chr16:3901011ENST00000406337-171895_1711117.33333333333332005.0DomainH15
HgeneKAT6Achr8:41794774chr16:3901010ENST00000265713-16171_1441117.33333333333332005.0RegionNote=Required for activation of RUNX1-1
HgeneKAT6Achr8:41794774chr16:3901010ENST00000265713-1617488_7781117.33333333333332005.0RegionNote=Catalytic
HgeneKAT6Achr8:41794774chr16:3901010ENST00000265713-161752_1661117.33333333333332005.0RegionNote=Required for nuclear localization
HgeneKAT6Achr8:41794774chr16:3901010ENST00000265713-1617645_6491117.33333333333332005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41794774chr16:3901010ENST00000265713-1617654_6601117.33333333333332005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41794774chr16:3901010ENST00000396930-17181_1441117.33333333333332005.0RegionNote=Required for activation of RUNX1-1
HgeneKAT6Achr8:41794774chr16:3901010ENST00000396930-1718488_7781117.33333333333332005.0RegionNote=Catalytic
HgeneKAT6Achr8:41794774chr16:3901010ENST00000396930-171852_1661117.33333333333332005.0RegionNote=Required for nuclear localization
HgeneKAT6Achr8:41794774chr16:3901010ENST00000396930-1718645_6491117.33333333333332005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41794774chr16:3901010ENST00000396930-1718654_6601117.33333333333332005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41794774chr16:3901010ENST00000406337-17181_1441117.33333333333332005.0RegionNote=Required for activation of RUNX1-1
HgeneKAT6Achr8:41794774chr16:3901010ENST00000406337-1718488_7781117.33333333333332005.0RegionNote=Catalytic
HgeneKAT6Achr8:41794774chr16:3901010ENST00000406337-171852_1661117.33333333333332005.0RegionNote=Required for nuclear localization
HgeneKAT6Achr8:41794774chr16:3901010ENST00000406337-1718645_6491117.33333333333332005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41794774chr16:3901010ENST00000406337-1718654_6601117.33333333333332005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41794774chr16:3901011ENST00000265713-16171_1441117.33333333333332005.0RegionNote=Required for activation of RUNX1-1
HgeneKAT6Achr8:41794774chr16:3901011ENST00000265713-1617488_7781117.33333333333332005.0RegionNote=Catalytic
HgeneKAT6Achr8:41794774chr16:3901011ENST00000265713-161752_1661117.33333333333332005.0RegionNote=Required for nuclear localization
HgeneKAT6Achr8:41794774chr16:3901011ENST00000265713-1617645_6491117.33333333333332005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41794774chr16:3901011ENST00000265713-1617654_6601117.33333333333332005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41794774chr16:3901011ENST00000396930-17181_1441117.33333333333332005.0RegionNote=Required for activation of RUNX1-1
HgeneKAT6Achr8:41794774chr16:3901011ENST00000396930-1718488_7781117.33333333333332005.0RegionNote=Catalytic
HgeneKAT6Achr8:41794774chr16:3901011ENST00000396930-171852_1661117.33333333333332005.0RegionNote=Required for nuclear localization
HgeneKAT6Achr8:41794774chr16:3901011ENST00000396930-1718645_6491117.33333333333332005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41794774chr16:3901011ENST00000396930-1718654_6601117.33333333333332005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41794774chr16:3901011ENST00000406337-17181_1441117.33333333333332005.0RegionNote=Required for activation of RUNX1-1
HgeneKAT6Achr8:41794774chr16:3901011ENST00000406337-1718488_7781117.33333333333332005.0RegionNote=Catalytic
HgeneKAT6Achr8:41794774chr16:3901011ENST00000406337-171852_1661117.33333333333332005.0RegionNote=Required for nuclear localization
HgeneKAT6Achr8:41794774chr16:3901011ENST00000406337-1718645_6491117.33333333333332005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41794774chr16:3901011ENST00000406337-1718654_6601117.33333333333332005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41794774chr16:3901010ENST00000265713-1617206_2651117.33333333333332005.0Zinc fingerPHD-type 1
HgeneKAT6Achr8:41794774chr16:3901010ENST00000265713-1617259_3131117.33333333333332005.0Zinc fingerPHD-type 2
HgeneKAT6Achr8:41794774chr16:3901010ENST00000265713-1617537_5621117.33333333333332005.0Zinc fingerC2HC MYST-type
HgeneKAT6Achr8:41794774chr16:3901010ENST00000396930-1718206_2651117.33333333333332005.0Zinc fingerPHD-type 1
HgeneKAT6Achr8:41794774chr16:3901010ENST00000396930-1718259_3131117.33333333333332005.0Zinc fingerPHD-type 2
HgeneKAT6Achr8:41794774chr16:3901010ENST00000396930-1718537_5621117.33333333333332005.0Zinc fingerC2HC MYST-type
HgeneKAT6Achr8:41794774chr16:3901010ENST00000406337-1718206_2651117.33333333333332005.0Zinc fingerPHD-type 1
HgeneKAT6Achr8:41794774chr16:3901010ENST00000406337-1718259_3131117.33333333333332005.0Zinc fingerPHD-type 2
HgeneKAT6Achr8:41794774chr16:3901010ENST00000406337-1718537_5621117.33333333333332005.0Zinc fingerC2HC MYST-type
HgeneKAT6Achr8:41794774chr16:3901011ENST00000265713-1617206_2651117.33333333333332005.0Zinc fingerPHD-type 1
HgeneKAT6Achr8:41794774chr16:3901011ENST00000265713-1617259_3131117.33333333333332005.0Zinc fingerPHD-type 2
HgeneKAT6Achr8:41794774chr16:3901011ENST00000265713-1617537_5621117.33333333333332005.0Zinc fingerC2HC MYST-type
HgeneKAT6Achr8:41794774chr16:3901011ENST00000396930-1718206_2651117.33333333333332005.0Zinc fingerPHD-type 1
HgeneKAT6Achr8:41794774chr16:3901011ENST00000396930-1718259_3131117.33333333333332005.0Zinc fingerPHD-type 2
HgeneKAT6Achr8:41794774chr16:3901011ENST00000396930-1718537_5621117.33333333333332005.0Zinc fingerC2HC MYST-type
HgeneKAT6Achr8:41794774chr16:3901011ENST00000406337-1718206_2651117.33333333333332005.0Zinc fingerPHD-type 1
HgeneKAT6Achr8:41794774chr16:3901011ENST00000406337-1718259_3131117.33333333333332005.0Zinc fingerPHD-type 2
HgeneKAT6Achr8:41794774chr16:3901011ENST00000406337-1718537_5621117.33333333333332005.0Zinc fingerC2HC MYST-type
TgeneCREBBPchr8:41794774chr16:3901010ENST000002623670311061_106428.3333333333333322443.0Compositional biasNote=Poly-Glu
TgeneCREBBPchr8:41794774chr16:3901010ENST000002623670311199_148728.3333333333333322443.0Compositional biasNote=Cys/His-rich
TgeneCREBBPchr8:41794774chr16:3901010ENST000002623670311555_156228.3333333333333322443.0Compositional biasNote=Poly-Glu
TgeneCREBBPchr8:41794774chr16:3901010ENST000002623670311943_194828.3333333333333322443.0Compositional biasNote=Poly-Pro
TgeneCREBBPchr8:41794774chr16:3901010ENST000002623670311967_197028.3333333333333322443.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr8:41794774chr16:3901010ENST000002623670312081_208528.3333333333333322443.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr8:41794774chr16:3901010ENST000002623670312199_221628.3333333333333322443.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr8:41794774chr16:3901010ENST000002623670312245_224828.3333333333333322443.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr8:41794774chr16:3901010ENST000002623670312297_230028.3333333333333322443.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr8:41794774chr16:3901010ENST000003820700301061_106428.3333333333333322405.0Compositional biasNote=Poly-Glu
TgeneCREBBPchr8:41794774chr16:3901010ENST000003820700301199_148728.3333333333333322405.0Compositional biasNote=Cys/His-rich
TgeneCREBBPchr8:41794774chr16:3901010ENST000003820700301555_156228.3333333333333322405.0Compositional biasNote=Poly-Glu
TgeneCREBBPchr8:41794774chr16:3901010ENST000003820700301943_194828.3333333333333322405.0Compositional biasNote=Poly-Pro
TgeneCREBBPchr8:41794774chr16:3901010ENST000003820700301967_197028.3333333333333322405.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr8:41794774chr16:3901010ENST000003820700302081_208528.3333333333333322405.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr8:41794774chr16:3901010ENST000003820700302199_221628.3333333333333322405.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr8:41794774chr16:3901010ENST000003820700302245_224828.3333333333333322405.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr8:41794774chr16:3901010ENST000003820700302297_230028.3333333333333322405.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr8:41794774chr16:3901011ENST000002623670311061_106428.3333333333333322443.0Compositional biasNote=Poly-Glu
TgeneCREBBPchr8:41794774chr16:3901011ENST000002623670311199_148728.3333333333333322443.0Compositional biasNote=Cys/His-rich
TgeneCREBBPchr8:41794774chr16:3901011ENST000002623670311555_156228.3333333333333322443.0Compositional biasNote=Poly-Glu
TgeneCREBBPchr8:41794774chr16:3901011ENST000002623670311943_194828.3333333333333322443.0Compositional biasNote=Poly-Pro
TgeneCREBBPchr8:41794774chr16:3901011ENST000002623670311967_197028.3333333333333322443.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr8:41794774chr16:3901011ENST000002623670312081_208528.3333333333333322443.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr8:41794774chr16:3901011ENST000002623670312199_221628.3333333333333322443.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr8:41794774chr16:3901011ENST000002623670312245_224828.3333333333333322443.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr8:41794774chr16:3901011ENST000002623670312297_230028.3333333333333322443.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr8:41794774chr16:3901011ENST000003820700301061_106428.3333333333333322405.0Compositional biasNote=Poly-Glu
TgeneCREBBPchr8:41794774chr16:3901011ENST000003820700301199_148728.3333333333333322405.0Compositional biasNote=Cys/His-rich
TgeneCREBBPchr8:41794774chr16:3901011ENST000003820700301555_156228.3333333333333322405.0Compositional biasNote=Poly-Glu
TgeneCREBBPchr8:41794774chr16:3901011ENST000003820700301943_194828.3333333333333322405.0Compositional biasNote=Poly-Pro
TgeneCREBBPchr8:41794774chr16:3901011ENST000003820700301967_197028.3333333333333322405.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr8:41794774chr16:3901011ENST000003820700302081_208528.3333333333333322405.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr8:41794774chr16:3901011ENST000003820700302199_221628.3333333333333322405.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr8:41794774chr16:3901011ENST000003820700302245_224828.3333333333333322405.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr8:41794774chr16:3901011ENST000003820700302297_230028.3333333333333322405.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr8:41794774chr16:3901010ENST000002623670311103_117528.3333333333333322443.0DomainBromo
TgeneCREBBPchr8:41794774chr16:3901010ENST000002623670311323_170028.3333333333333322443.0DomainCBP/p300-type HAT
TgeneCREBBPchr8:41794774chr16:3901010ENST00000262367031587_66628.3333333333333322443.0DomainKIX
TgeneCREBBPchr8:41794774chr16:3901010ENST000003820700301103_117528.3333333333333322405.0DomainBromo
TgeneCREBBPchr8:41794774chr16:3901010ENST000003820700301323_170028.3333333333333322405.0DomainCBP/p300-type HAT
TgeneCREBBPchr8:41794774chr16:3901010ENST00000382070030587_66628.3333333333333322405.0DomainKIX
TgeneCREBBPchr8:41794774chr16:3901011ENST000002623670311103_117528.3333333333333322443.0DomainBromo
TgeneCREBBPchr8:41794774chr16:3901011ENST000002623670311323_170028.3333333333333322443.0DomainCBP/p300-type HAT
TgeneCREBBPchr8:41794774chr16:3901011ENST00000262367031587_66628.3333333333333322443.0DomainKIX
TgeneCREBBPchr8:41794774chr16:3901011ENST000003820700301103_117528.3333333333333322405.0DomainBromo
TgeneCREBBPchr8:41794774chr16:3901011ENST000003820700301323_170028.3333333333333322405.0DomainCBP/p300-type HAT
TgeneCREBBPchr8:41794774chr16:3901011ENST00000382070030587_66628.3333333333333322405.0DomainKIX
TgeneCREBBPchr8:41794774chr16:3901010ENST000002623670311434_143628.3333333333333322443.0RegionAcetyl-CoA binding
TgeneCREBBPchr8:41794774chr16:3901010ENST000002623670311446_144728.3333333333333322443.0RegionAcetyl-CoA binding
TgeneCREBBPchr8:41794774chr16:3901010ENST000003820700301434_143628.3333333333333322405.0RegionAcetyl-CoA binding
TgeneCREBBPchr8:41794774chr16:3901010ENST000003820700301446_144728.3333333333333322405.0RegionAcetyl-CoA binding
TgeneCREBBPchr8:41794774chr16:3901011ENST000002623670311434_143628.3333333333333322443.0RegionAcetyl-CoA binding
TgeneCREBBPchr8:41794774chr16:3901011ENST000002623670311446_144728.3333333333333322443.0RegionAcetyl-CoA binding
TgeneCREBBPchr8:41794774chr16:3901011ENST000003820700301434_143628.3333333333333322405.0RegionAcetyl-CoA binding
TgeneCREBBPchr8:41794774chr16:3901011ENST000003820700301446_144728.3333333333333322405.0RegionAcetyl-CoA binding
TgeneCREBBPchr8:41794774chr16:3901010ENST000002623670311701_174428.3333333333333322443.0Zinc fingerZZ-type
TgeneCREBBPchr8:41794774chr16:3901010ENST000002623670311765_184628.3333333333333322443.0Zinc fingerTAZ-type 2
TgeneCREBBPchr8:41794774chr16:3901010ENST00000262367031347_43328.3333333333333322443.0Zinc fingerTAZ-type 1
TgeneCREBBPchr8:41794774chr16:3901010ENST000003820700301701_174428.3333333333333322405.0Zinc fingerZZ-type
TgeneCREBBPchr8:41794774chr16:3901010ENST000003820700301765_184628.3333333333333322405.0Zinc fingerTAZ-type 2
TgeneCREBBPchr8:41794774chr16:3901010ENST00000382070030347_43328.3333333333333322405.0Zinc fingerTAZ-type 1
TgeneCREBBPchr8:41794774chr16:3901011ENST000002623670311701_174428.3333333333333322443.0Zinc fingerZZ-type
TgeneCREBBPchr8:41794774chr16:3901011ENST000002623670311765_184628.3333333333333322443.0Zinc fingerTAZ-type 2
TgeneCREBBPchr8:41794774chr16:3901011ENST00000262367031347_43328.3333333333333322443.0Zinc fingerTAZ-type 1
TgeneCREBBPchr8:41794774chr16:3901011ENST000003820700301701_174428.3333333333333322405.0Zinc fingerZZ-type
TgeneCREBBPchr8:41794774chr16:3901011ENST000003820700301765_184628.3333333333333322405.0Zinc fingerTAZ-type 2
TgeneCREBBPchr8:41794774chr16:3901011ENST00000382070030347_43328.3333333333333322405.0Zinc fingerTAZ-type 1

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKAT6Achr8:41794774chr16:3901010ENST00000265713-16171147_11501117.33333333333332005.0Compositional biasNote=Poly-Lys
HgeneKAT6Achr8:41794774chr16:3901010ENST00000265713-16171221_12421117.33333333333332005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41794774chr16:3901010ENST00000265713-16171267_13021117.33333333333332005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41794774chr16:3901010ENST00000265713-16171411_14141117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr16:3901010ENST00000265713-16171593_15971117.33333333333332005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41794774chr16:3901010ENST00000265713-16171643_17041117.33333333333332005.0Compositional biasNote=Gln/Pro-rich
HgeneKAT6Achr8:41794774chr16:3901010ENST00000265713-16171897_19771117.33333333333332005.0Compositional biasNote=Met-rich
HgeneKAT6Achr8:41794774chr16:3901010ENST00000396930-17181147_11501117.33333333333332005.0Compositional biasNote=Poly-Lys
HgeneKAT6Achr8:41794774chr16:3901010ENST00000396930-17181221_12421117.33333333333332005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41794774chr16:3901010ENST00000396930-17181267_13021117.33333333333332005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41794774chr16:3901010ENST00000396930-17181411_14141117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr16:3901010ENST00000396930-17181593_15971117.33333333333332005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41794774chr16:3901010ENST00000396930-17181643_17041117.33333333333332005.0Compositional biasNote=Gln/Pro-rich
HgeneKAT6Achr8:41794774chr16:3901010ENST00000396930-17181897_19771117.33333333333332005.0Compositional biasNote=Met-rich
HgeneKAT6Achr8:41794774chr16:3901010ENST00000406337-17181147_11501117.33333333333332005.0Compositional biasNote=Poly-Lys
HgeneKAT6Achr8:41794774chr16:3901010ENST00000406337-17181221_12421117.33333333333332005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41794774chr16:3901010ENST00000406337-17181267_13021117.33333333333332005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41794774chr16:3901010ENST00000406337-17181411_14141117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr16:3901010ENST00000406337-17181593_15971117.33333333333332005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41794774chr16:3901010ENST00000406337-17181643_17041117.33333333333332005.0Compositional biasNote=Gln/Pro-rich
HgeneKAT6Achr8:41794774chr16:3901010ENST00000406337-17181897_19771117.33333333333332005.0Compositional biasNote=Met-rich
HgeneKAT6Achr8:41794774chr16:3901011ENST00000265713-16171147_11501117.33333333333332005.0Compositional biasNote=Poly-Lys
HgeneKAT6Achr8:41794774chr16:3901011ENST00000265713-16171221_12421117.33333333333332005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41794774chr16:3901011ENST00000265713-16171267_13021117.33333333333332005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41794774chr16:3901011ENST00000265713-16171411_14141117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr16:3901011ENST00000265713-16171593_15971117.33333333333332005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41794774chr16:3901011ENST00000265713-16171643_17041117.33333333333332005.0Compositional biasNote=Gln/Pro-rich
HgeneKAT6Achr8:41794774chr16:3901011ENST00000265713-16171897_19771117.33333333333332005.0Compositional biasNote=Met-rich
HgeneKAT6Achr8:41794774chr16:3901011ENST00000396930-17181147_11501117.33333333333332005.0Compositional biasNote=Poly-Lys
HgeneKAT6Achr8:41794774chr16:3901011ENST00000396930-17181221_12421117.33333333333332005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41794774chr16:3901011ENST00000396930-17181267_13021117.33333333333332005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41794774chr16:3901011ENST00000396930-17181411_14141117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr16:3901011ENST00000396930-17181593_15971117.33333333333332005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41794774chr16:3901011ENST00000396930-17181643_17041117.33333333333332005.0Compositional biasNote=Gln/Pro-rich
HgeneKAT6Achr8:41794774chr16:3901011ENST00000396930-17181897_19771117.33333333333332005.0Compositional biasNote=Met-rich
HgeneKAT6Achr8:41794774chr16:3901011ENST00000406337-17181147_11501117.33333333333332005.0Compositional biasNote=Poly-Lys
HgeneKAT6Achr8:41794774chr16:3901011ENST00000406337-17181221_12421117.33333333333332005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41794774chr16:3901011ENST00000406337-17181267_13021117.33333333333332005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41794774chr16:3901011ENST00000406337-17181411_14141117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr16:3901011ENST00000406337-17181593_15971117.33333333333332005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41794774chr16:3901011ENST00000406337-17181643_17041117.33333333333332005.0Compositional biasNote=Gln/Pro-rich
HgeneKAT6Achr8:41794774chr16:3901011ENST00000406337-17181897_19771117.33333333333332005.0Compositional biasNote=Met-rich
HgeneKAT6Achr8:41794774chr16:3901010ENST00000265713-16171913_19481117.33333333333332005.0RegionNote=Required for activation of RUNX1-2
HgeneKAT6Achr8:41794774chr16:3901010ENST00000396930-17181913_19481117.33333333333332005.0RegionNote=Required for activation of RUNX1-2
HgeneKAT6Achr8:41794774chr16:3901010ENST00000406337-17181913_19481117.33333333333332005.0RegionNote=Required for activation of RUNX1-2
HgeneKAT6Achr8:41794774chr16:3901011ENST00000265713-16171913_19481117.33333333333332005.0RegionNote=Required for activation of RUNX1-2
HgeneKAT6Achr8:41794774chr16:3901011ENST00000396930-17181913_19481117.33333333333332005.0RegionNote=Required for activation of RUNX1-2
HgeneKAT6Achr8:41794774chr16:3901011ENST00000406337-17181913_19481117.33333333333332005.0RegionNote=Required for activation of RUNX1-2


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (1101)KAT6Achr841786996CREBBPchr163860780-
MLSHFGMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTF
PTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVL
LLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQAILGS
PASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQT
QLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISE
SALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQ
DLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRD
EYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQA
QPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMN
HSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQ
FPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPV
TQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQT
PTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQ
PTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMK
TETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEV
DEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTL
EALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQ
EPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGY
CCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGEN
VTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHY
DIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRR
QNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFA
FEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTA
VYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKR
LQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNV
LEESIKELEQEEEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKS
SISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPP
IVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQ
GQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLG
LDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKM
KRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKH
KLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPS
TPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPP
AQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPV
SLNVPRPNQVSGPVMPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAV
AGPRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMA
AFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAG
VPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLL
QQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQ
RMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQ
QQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAP
VQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQG
2144
PDB file (1108)KAT6Achr841786996CREBBPchr163860780-
MLSHFGMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTF
PTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVL
LLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQVAHCA
SSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPASGIQNTIGSV
GTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPA
QPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNP
LMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQ
AIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYK
IQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSL
PVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVP
GMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGM
GQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPA
STAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSAT
QTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTP
LSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDP
GESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVK
EEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLP
FRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLM
FNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQT
LCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQT
TISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDN
CLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVR
VVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFF
GMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEY
VKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKA
FAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEE
EERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSM
PNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDL
MDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNEC
KHHVETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQ
SKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKR
KTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQ
QAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQ
PSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAAR
QIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSG
PVMPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPR
SISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVA
NQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQA
MGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQQQQQQQQQ
QQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQRMQQHLPLQGSS
MGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQ
PNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPH
SSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLP
2182


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
KAT6A_pLDDT.png
all structure
all structure
CREBBP_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
KAT6A_CREBBP_1101_pLDDT_and_active_sites.png (AA BP:)
all structure
KAT6A_CREBBP_1101_violinplot.png (AA BP:)
all structure
KAT6A_CREBBP_1108_pLDDT_and_active_sites.png (AA BP:)
all structure
KAT6A_CREBBP_1108_violinplot.png (AA BP:)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
11011.1031551.201459.2770.5670.6860.8481.7110.463.7190.976Chain A: 182,185,186,187,189,190,191,314,315,317,3
18,319,322,325,327,328,330,331,334,337,338,341,363
,366,367,370
11081.0422511.089638.3230.5260.7010.9271.260.8341.5110.837Chain A: 98,99,101,102,103,105,106,107,108,109,110
,112,120,121,122,132,133,135,136,153,156,159,160,1
70,173,174,176,177,178,179,180,181,182,183,184,212
,213,214,215,216,217,218,220,221,222,224,232

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
CREBBPEGR1, HNF4A, NFE2L2, TDG, AIRE, NCOA6, BRCA1, CREB1, AR, N4BP2, CTNNB1, RELA, SS18L1, PIAS3, NPAS2, EBF1, E2F1, E2F3, KLF5, PML, SRF, TP53, KLF1, ING1, SMAD1, CSNK2A1, CUX1, ATF1, EWSR1, NR3C1, HNF1A, HOXB7, MSX1, HTT, TCF3, MGMT, KMT2A, MYOD1, ATF2, JUN, MECOM, GLI3, DDX5, PTMA, MYB, FOXO1, FOXO4, RPS6KA3, CITED1, STAT1, STAT6, MAF, PELP1, RPS6KA2, RBBP4, RBBP7, ONECUT1, SERTAD1, SREBF1, SREBF2, NFATC2, TRIP4, HIF1A, NFE2, STAT2, SMARCA4, NCOA1, ESR1, MAML1, MYBL2, KAT2B, GTF2B, CITED2, IRF3, NUP98, TRERF1, TGS1, KLF4, STAT3, NEUROG1, HIPK2, KHDRBS1, GATA1, PHOX2A, SNIP1, NFATC4, KLF13, XRCC6, FOS, POLR2A, SMARCB1, CCNC, CDK8, MED21, NKX2-1, NCOA3, PPARG, ATF4, RPA2, PPARGC1A, HIST3H3, HIST4H4, EP300, ANAPC7, ANAPC5, CDC16, ANAPC2, CDH1, CDC20, REL, DDX17, GCM1, MAP3K5, MAPK10, MKNK1, APC, PAPOLA, CPSF6, TBX21, NCOR1, NCOR2, CARM1, ESR2, YY1, MYC, PLAGL1, MIER1, HDAC1, SP1, SP3, HDAC3, VDR, DAXX, CEBPB, CEBPD, PARP1, tat, PTMS, ATXN3, CTBP1, HIST1H3A, MTF1, SETD1A, MYBL1, NLK, SMAD3, DEK, FGFR1, RPS6KA1, CDKN1A, SND1, NCOA2, KAT6A, SRCAP, TAF6L, ETS1, ETS2, RUNX2, MAFK, TCF12, HDAC2, HOXB6, KPNA2, KPNA6, NR5A1, HMGA1, FOXO3, HIST1H4A, HES6, RUVBL1, FOSL1, FOSB, JUNB, FOXM1, HMGB1, HMGB2, POU1F1, IRF1, SMAD2, RARA, SH3GL1, BCL6, GRIP1, KLF8, NFYB, TRIM28, POT1, WDR5, IRF5, AKT1, CDC27, ATF3, ATG3, MDM2, HOXB2, HOXB3, HOXB9, HOXD12, HOXD13, HOXD10, HOXD4, HOXB4, HOXA10, HOXA9, PBX1, SMARCA2, MYH9, MSH6, MSH2, ZBTB2, ZNF639, ACTA2, CSNK2A2, TP73, PRLR, MED25, PTOV1, IFNAR2, IRF9, TBP, RPS6KA5, IRF7, KAT5, PYGO2, HBP1, TACC2, NPAT, CCNE1, ELAVL1, KDM3B, PSMC5, MDC1, LYN, HCK, SRC, ZCCHC12, RAD23A, RUNX1, CHUK, IKBKB, IKBKG, HIST2H2BE, LIG4, TLR2, EPAS1, K8, MTDH, MEIS1, LDLR, vIRF-1, vIRF-3, DYRK1B, DYRK1A, CDK2, EID1, COPS2, PSME3, WRN, KLF2, UBE2D1, CREBBP, UBE2I, MAPK3, FHL1, HIST1H2BB, Ctnnb1, Cebpb, EID3, POU2F3, Spi1, Nfic, ELK1, MAPK1, TFDP1, CREM, ZEB1, CRTC1, MAML2, HCVgp1, CENPJ, HSF1, FHL2, CDH2, PHOX2B, DDIT3, XAF1, BMI1, HHV8GK18_gp81, Ar, CCND3, TXNDC11, CCNA2, C3orf62, PPP1R13L, BRMS1, PCNA, UBE2S, TLE3, MUS81, PTTG1, MED23, E7, SNAI1, TFAP2B, SMAD4, NR3C2, ARNTL, CLOCK, E6, SUMO1, NFATC1, CPSF4, USP7, RFPL3, CTGF, NFYA, KIAA0430, HELZ, NISCH, SOWAHA, PCGF3, EIF4ENIF1, PAN2, JUP, HSPA8, LAMP2, TRIM25, HNRNPL, DUX4, HLF, EGLN3, FGF2, TH, FBXL19, USP14, BBC3, RBBP5, GATA3, BYRF1, TP53BP1, KIAA1429, ATF7IP, ATRX, CASP8AP2, CBX4, CHAF1A, CHD3, EIF3D, GATAD2A, HIPK3, HMGXB4, FBXO38, PIAS2, PPP1R8, PPP2R2A, PTPRF, RNF111, RPL3, RPL35, SETDB1, SP100, TOPORS, UIMC1, ZCCHC7, ZMYM2, ZNF451, ZNF106, HIPK1, PIAS1, FAF1, KISS1, ZHX1, ZMYM5, ZNFX1, WDR77, PPP1CC, BRIP1, CCAR2, HSPB1, MAPT, PNKP, PPP1CA, POLR1E, DDX3X, TSPYL2, PYCR1, TRIM24, SMG7, AFP, BRD4, KDM2B, ACSS1, ACTB, ANKS1A, ANKS1B, ANXA7, APP, BAG5, TUBB, CNTRL, CEP290, CHRDL1, CLASP2, EEF1A1, EEF2, EIF4G2, FUS, GAA, GPR161, GRIA3, GSTO2, HEXA, HIVEP1, HIVEP2, HMG20A, HUWE1, IQGAP1, KDM6B, KDM2A, CAMSAP2, EPG5, KIF5A, MAP1B, MYO1E, OGT, PAPPA, PAX6, PHLDA1, RAD50, RBM24, RBM5, RFK, RNF7, RPS20, EXOC5, SEMA3B, SEPT3, SLC1A4, SNAPC5, SNRNP200, SOS2, SPTAN1, SYT1, TIAL1, TIAM1, TP53BP2, KDM6A, VAT1L, WAS, YTHDF2, BCAT2, CDC25A, TERF2IP, TGM1, BAG2, GMEB2, HIST1H2AB, LATS1, RXRA, NEUROD1, CIITA, FOXH1, T, ERG, ETV4, FEV, FOXI1, FOXQ1, GATA2, HNF1B, KLF15, LHX3, NFIA, NFIB, PAX7, PAX8, SOX9, SP7, TAL1, TEAD1, TLX1, SNAI2,
KAT6AING5, UBE2U, MAFK, BRPF1, HSPA4, TP53, EP300, MEAF6, HIST1H3A, HIST1H4A, RUNX1, CREBBP, ESR1, KMT2A, WDR5, HIST2H3C, ELAVL1, ATN1, ATXN1, RERE, H3F3C, HIST1H4I, HIST3H3, PML, SYMPK, AKT1, HIST4H4, CCNB1, CRK, RPL10, RNPS1, L1TD1, PHF14, TNRC6B, PNPLA8, RSF1, Myo1c, Rpl35, Tpx2, Srsf1, Tubgcp6, HEMGN, HNRNPL, KIAA1429, RANGAP1, BRD1, BRPF3, ING4, KAT7, JADE3, KAT6B, JADE2, JADE1, HIST1H2BO, HRG, CSNK2A2, APEX1, CENPA, DANCR, ZBTB2, CSNK2B, CSNK2A1, RFWD2, HSPD1, CMAS, HIST2H2BF, CASP2, TRIM65, HGH1, TTC4, PPP2R5C, OTUD3, DBNL, PIP4K2C, ATIC, NUDT12, B3GALTL, ATG4B, PABPN1, DEK, SF3A3,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KAT6Aall structure
CREBBPall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneKAT6Achr8:41794774chr16:3901010ENST00000265713-16171517_17411117.33333333333332005.0PML
HgeneKAT6Achr8:41794774chr16:3901010ENST00000396930-17181517_17411117.33333333333332005.0PML
HgeneKAT6Achr8:41794774chr16:3901010ENST00000406337-17181517_17411117.33333333333332005.0PML
HgeneKAT6Achr8:41794774chr16:3901011ENST00000265713-16171517_17411117.33333333333332005.0PML
HgeneKAT6Achr8:41794774chr16:3901011ENST00000396930-17181517_17411117.33333333333332005.0PML
HgeneKAT6Achr8:41794774chr16:3901011ENST00000406337-17181517_17411117.33333333333332005.0PML
HgeneKAT6Achr8:41794774chr16:3901010ENST00000265713-16171517_16421117.33333333333332005.0RUNX1-2
HgeneKAT6Achr8:41794774chr16:3901010ENST00000396930-17181517_16421117.33333333333332005.0RUNX1-2
HgeneKAT6Achr8:41794774chr16:3901010ENST00000406337-17181517_16421117.33333333333332005.0RUNX1-2
HgeneKAT6Achr8:41794774chr16:3901011ENST00000265713-16171517_16421117.33333333333332005.0RUNX1-2
HgeneKAT6Achr8:41794774chr16:3901011ENST00000396930-17181517_16421117.33333333333332005.0RUNX1-2
HgeneKAT6Achr8:41794774chr16:3901011ENST00000406337-17181517_16421117.33333333333332005.0RUNX1-2


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Related Drugs to KAT6A-CREBBP


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KAT6A-CREBBP


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
KAT6ACREBBPBreast Invasive Ductal CarcinomaMyCancerGenome
KAT6ACREBBPBladder Urothelial CarcinomaMyCancerGenome
KAT6ACREBBPEsophagogastric CarcinomaMyCancerGenome
KAT6ACREBBPProstate AdenocarcinomaMyCancerGenome
KAT6ACREBBPSmall Cell Lung CarcinomaMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKAT6AC4225396MENTAL RETARDATION, AUTOSOMAL DOMINANT 323CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneKAT6AC4511003Acute myeloid leukemia with t(8;16)(p11;p13) translocation2ORPHANET
HgeneKAT6AC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneKAT6AC0025149Medulloblastoma1CTD_human
HgeneKAT6AC0033578Prostatic Neoplasms1CTD_human
HgeneKAT6AC0205833Medullomyoblastoma1CTD_human
HgeneKAT6AC0278510Childhood Medulloblastoma1CTD_human
HgeneKAT6AC0278876Adult Medulloblastoma1CTD_human
HgeneKAT6AC0376358Malignant neoplasm of prostate1CTD_human
HgeneKAT6AC0751291Desmoplastic Medulloblastoma1CTD_human
HgeneKAT6AC1275668Melanotic medulloblastoma1CTD_human
TgeneCREBBPC4551859RUBINSTEIN-TAYBI SYNDROME 112CLINGEN;GENOMICS_ENGLAND;UNIPROT
TgeneCREBBPC0035934Rubinstein-Taybi Syndrome6CLINGEN;CTD_human
TgeneCREBBPC0033578Prostatic Neoplasms2CTD_human
TgeneCREBBPC0376358Malignant neoplasm of prostate2CTD_human
TgeneCREBBPC4511003Acute myeloid leukemia with t(8;16)(p11;p13) translocation2ORPHANET
TgeneCREBBPC0005684Malignant neoplasm of urinary bladder1CTD_human
TgeneCREBBPC0005695Bladder Neoplasm1CTD_human
TgeneCREBBPC0007137Squamous cell carcinoma1CTD_human
TgeneCREBBPC0007138Carcinoma, Transitional Cell1CTD_human
TgeneCREBBPC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneCREBBPC0011573Endogenous depression1PSYGENET
TgeneCREBBPC0024301Lymphoma, Follicular1CTD_human
TgeneCREBBPC0036920Sezary Syndrome1CTD_human
TgeneCREBBPC0079745Lymphoma, Large-Cell, Follicular1CTD_human
TgeneCREBBPC0079758Lymphoma, Mixed-Cell, Follicular1CTD_human
TgeneCREBBPC0079765Lymphoma, Small Cleaved-Cell, Follicular1CTD_human
TgeneCREBBPC0149925Small cell carcinoma of lung1CTD_human
TgeneCREBBPC0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneCREBBPC0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneCREBBPC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
TgeneCREBBPC1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
TgeneCREBBPC1956130Lymphoma, Follicular, Grade 11CTD_human
TgeneCREBBPC1956131Lymphoma, Follicular, Grade 31CTD_human
TgeneCREBBPC1956132Lymphoma, Follicular, Grade 21CTD_human
TgeneCREBBPC4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human