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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:KCNQ5-ALK

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KCNQ5-ALK
FusionPDB ID: 41572
FusionGDB2.0 ID: 41572
HgeneTgene
Gene symbol

KCNQ5

ALK

Gene ID

56479

238

Gene namepotassium voltage-gated channel subfamily Q member 5ALK receptor tyrosine kinase
SynonymsKv7.5|MRD46CD246|NBLST3
Cytomap

6q13

2p23.2-p23.1

Type of geneprotein-codingprotein-coding
Descriptionpotassium voltage-gated channel subfamily KQT member 5KQT-like 5potassium channel proteinpotassium channel subunit alpha KvLQT5potassium channel, voltage gated KQT-like subfamily Q, member 5voltage-gated potassium channel subunit Kv7.5ALK tyrosine kinase receptorCD246 antigenanaplastic lymphoma receptor tyrosine kinasemutant anaplastic lymphoma kinase
Modification date2020031320200329
UniProtAcc

Q9NR82

Q96BT7

Ensembl transtripts involved in fusion geneENST idsENST00000342056, ENST00000355194, 
ENST00000355635, ENST00000370392, 
ENST00000370398, ENST00000402622, 
ENST00000403813, ENST00000414165, 
ENST00000431873, ENST00000498037, 
ENST00000389048, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 7 X 4=22456 X 74 X 20=82880
# samples 857
** MAII scorelog2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(57/82880*10)=-7.18391827352181
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: KCNQ5 [Title/Abstract] AND ALK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KCNQ5(73332315)-ALK(29498362), # samples:3
Anticipated loss of major functional domain due to fusion event.KCNQ5-ALK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KCNQ5-ALK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KCNQ5-ALK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KCNQ5-ALK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKCNQ5

GO:0071805

potassium ion transmembrane transport

10787416|11159685

TgeneALK

GO:0016310

phosphorylation

9174053

TgeneALK

GO:0046777

protein autophosphorylation

9174053


check buttonFusion gene breakpoints across KCNQ5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ALK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EB-A6QY-01AKCNQ5chr6

73332315

-ALKchr2

29498362

-
ChimerDB4SKCMTCGA-EB-A6QY-01AKCNQ5chr6

73332315

+ALKchr2

29498362

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000342056KCNQ5chr673332315+ENST00000389048ALKchr229498362-429279639838411147
ENST00000355194KCNQ5chr673332315+ENST00000389048ALKchr229498362-423573934737841145
ENST00000370398KCNQ5chr673332315+ENST00000389048ALKchr229498362-400350710935521147
ENST00000370392KCNQ5chr673332315+ENST00000389048ALKchr229498362-39784828435271147
ENST00000355635KCNQ5chr673332315+ENST00000389048ALKchr229498362-3894398034431147
ENST00000414165KCNQ5chr673332315+ENST00000389048ALKchr229498362-3894398034431147
ENST00000402622KCNQ5chr673332315+ENST00000389048ALKchr229498362-3894398034431147
ENST00000403813KCNQ5chr673332315+ENST00000389048ALKchr229498362-3894398034431147

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000342056ENST00000389048KCNQ5chr673332315+ALKchr229498362-0.0011853360.9988147
ENST00000355194ENST00000389048KCNQ5chr673332315+ALKchr229498362-0.0012405120.9987595
ENST00000370398ENST00000389048KCNQ5chr673332315+ALKchr229498362-0.0009133780.9990866
ENST00000370392ENST00000389048KCNQ5chr673332315+ALKchr229498362-0.0008858680.9991141
ENST00000355635ENST00000389048KCNQ5chr673332315+ALKchr229498362-0.0007542430.99924576
ENST00000414165ENST00000389048KCNQ5chr673332315+ALKchr229498362-0.0007542430.99924576
ENST00000402622ENST00000389048KCNQ5chr673332315+ALKchr229498362-0.0007542430.99924576
ENST00000403813ENST00000389048KCNQ5chr673332315+ALKchr229498362-0.0007542430.99924576

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>41572_41572_1_KCNQ5-ALK_KCNQ5_chr6_73332315_ENST00000342056_ALK_chr2_29498362_ENST00000389048_length(amino acids)=1147AA_BP=133
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSR
NLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAG
GKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDG
VPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGG
GGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTV
LAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTS
SISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRF
ILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYY
RKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDR
PNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISV
RVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGA

--------------------------------------------------------------

>41572_41572_2_KCNQ5-ALK_KCNQ5_chr6_73332315_ENST00000355194_ALK_chr2_29498362_ENST00000389048_length(amino acids)=1145AA_BP=131
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNL
FERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGK
GGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVP
VPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGG
GGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLA
EDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSI
SDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFIL
LELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRK
GGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPN
FAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRV
PRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASL

--------------------------------------------------------------

>41572_41572_3_KCNQ5-ALK_KCNQ5_chr6_73332315_ENST00000355635_ALK_chr2_29498362_ENST00000389048_length(amino acids)=1147AA_BP=133
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSR
NLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAG
GKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDG
VPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGG
GGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTV
LAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTS
SISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRF
ILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYY
RKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDR
PNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISV
RVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGA

--------------------------------------------------------------

>41572_41572_4_KCNQ5-ALK_KCNQ5_chr6_73332315_ENST00000370392_ALK_chr2_29498362_ENST00000389048_length(amino acids)=1147AA_BP=133
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSR
NLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAG
GKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDG
VPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGG
GGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTV
LAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTS
SISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRF
ILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYY
RKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDR
PNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISV
RVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGA

--------------------------------------------------------------

>41572_41572_5_KCNQ5-ALK_KCNQ5_chr6_73332315_ENST00000370398_ALK_chr2_29498362_ENST00000389048_length(amino acids)=1147AA_BP=133
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSR
NLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAG
GKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDG
VPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGG
GGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTV
LAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTS
SISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRF
ILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYY
RKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDR
PNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISV
RVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGA

--------------------------------------------------------------

>41572_41572_6_KCNQ5-ALK_KCNQ5_chr6_73332315_ENST00000402622_ALK_chr2_29498362_ENST00000389048_length(amino acids)=1147AA_BP=133
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSR
NLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAG
GKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDG
VPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGG
GGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTV
LAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTS
SISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRF
ILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYY
RKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDR
PNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISV
RVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGA

--------------------------------------------------------------

>41572_41572_7_KCNQ5-ALK_KCNQ5_chr6_73332315_ENST00000403813_ALK_chr2_29498362_ENST00000389048_length(amino acids)=1147AA_BP=133
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSR
NLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAG
GKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDG
VPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGG
GGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTV
LAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTS
SISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRF
ILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYY
RKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDR
PNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISV
RVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGA

--------------------------------------------------------------

>41572_41572_8_KCNQ5-ALK_KCNQ5_chr6_73332315_ENST00000414165_ALK_chr2_29498362_ENST00000389048_length(amino acids)=1147AA_BP=133
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSR
NLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAG
GKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDG
VPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGG
GGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTV
LAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTS
SISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRF
ILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYY
RKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDR
PNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISV
RVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGA

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:73332315/chr2:29498362)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KCNQ5

Q9NR82

ALK

Q96BT7

FUNCTION: Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. As the native M-channel, the potassium channel composed of KCNQ3 and KCNQ5 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1. {ECO:0000269|PubMed:10787416, ECO:0000269|PubMed:11159685, ECO:0000269|PubMed:28669405}.FUNCTION: Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323, PubMed:31079898). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182). {ECO:0000269|PubMed:19293182, ECO:0000269|PubMed:20123966, ECO:0000269|PubMed:20308323, ECO:0000269|PubMed:21285950, ECO:0000269|PubMed:31079898}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

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* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370392+191_125132.66666666666666428.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370398+1141_125132.66666666666666933.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000402622+1141_125132.66666666666666943.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000403813+1131_125132.66666666666666924.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000414165+1121_125132.66666666666666823.0Topological domainCytoplasmic
TgeneALKchr6:73332315chr2:29498362ENST00000389048829816_940605.66666666666661621.0Compositional biasNote=Gly-rich
TgeneALKchr6:73332315chr2:29498362ENST000003890488291116_1392605.66666666666661621.0DomainProtein kinase
TgeneALKchr6:73332315chr2:29498362ENST000003890488291197_1199605.66666666666661621.0RegionNote=Inhibitor binding
TgeneALKchr6:73332315chr2:29498362ENST000003890488291060_1620605.66666666666661621.0Topological domainCytoplasmic
TgeneALKchr6:73332315chr2:29498362ENST000003890488291039_1059605.66666666666661621.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370392+19299_319132.66666666666666428.0IntramembranePore-forming%3B Name%3DSegment H5
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370398+114299_319132.66666666666666933.0IntramembranePore-forming%3B Name%3DSegment H5
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000402622+114299_319132.66666666666666943.0IntramembranePore-forming%3B Name%3DSegment H5
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000403813+113299_319132.66666666666666924.0IntramembranePore-forming%3B Name%3DSegment H5
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000414165+112299_319132.66666666666666823.0IntramembranePore-forming%3B Name%3DSegment H5
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370392+19311_316132.66666666666666428.0MotifSelectivity filter
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370398+114311_316132.66666666666666933.0MotifSelectivity filter
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000402622+114311_316132.66666666666666943.0MotifSelectivity filter
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000403813+113311_316132.66666666666666924.0MotifSelectivity filter
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000414165+112311_316132.66666666666666823.0MotifSelectivity filter
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370392+19147_156132.66666666666666428.0Topological domainExtracellular
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370392+19178_200132.66666666666666428.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370392+19222_229132.66666666666666428.0Topological domainExtracellular
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370392+19253_266132.66666666666666428.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370392+19288_298132.66666666666666428.0Topological domainExtracellular
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370392+19320_325132.66666666666666428.0Topological domainExtracellular
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370392+19347_932132.66666666666666428.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370398+114147_156132.66666666666666933.0Topological domainExtracellular
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370398+114178_200132.66666666666666933.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370398+114222_229132.66666666666666933.0Topological domainExtracellular
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370398+114253_266132.66666666666666933.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370398+114288_298132.66666666666666933.0Topological domainExtracellular
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370398+114320_325132.66666666666666933.0Topological domainExtracellular
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370398+114347_932132.66666666666666933.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000402622+114147_156132.66666666666666943.0Topological domainExtracellular
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000402622+114178_200132.66666666666666943.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000402622+114222_229132.66666666666666943.0Topological domainExtracellular
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000402622+114253_266132.66666666666666943.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000402622+114288_298132.66666666666666943.0Topological domainExtracellular
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000402622+114320_325132.66666666666666943.0Topological domainExtracellular
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000402622+114347_932132.66666666666666943.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000403813+113147_156132.66666666666666924.0Topological domainExtracellular
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000403813+113178_200132.66666666666666924.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000403813+113222_229132.66666666666666924.0Topological domainExtracellular
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000403813+113253_266132.66666666666666924.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000403813+113288_298132.66666666666666924.0Topological domainExtracellular
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000403813+113320_325132.66666666666666924.0Topological domainExtracellular
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000403813+113347_932132.66666666666666924.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000414165+112147_156132.66666666666666823.0Topological domainExtracellular
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000414165+112178_200132.66666666666666823.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000414165+112222_229132.66666666666666823.0Topological domainExtracellular
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000414165+112253_266132.66666666666666823.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000414165+112288_298132.66666666666666823.0Topological domainExtracellular
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000414165+112320_325132.66666666666666823.0Topological domainExtracellular
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000414165+112347_932132.66666666666666823.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370392+19126_146132.66666666666666428.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370392+19157_177132.66666666666666428.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370392+19201_221132.66666666666666428.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370392+19230_252132.66666666666666428.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370392+19267_287132.66666666666666428.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370392+19326_346132.66666666666666428.0TransmembraneHelical%3B Name%3DSegment S6
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370398+114126_146132.66666666666666933.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370398+114157_177132.66666666666666933.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370398+114201_221132.66666666666666933.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370398+114230_252132.66666666666666933.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370398+114267_287132.66666666666666933.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000370398+114326_346132.66666666666666933.0TransmembraneHelical%3B Name%3DSegment S6
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000402622+114126_146132.66666666666666943.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000402622+114157_177132.66666666666666943.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000402622+114201_221132.66666666666666943.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000402622+114230_252132.66666666666666943.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000402622+114267_287132.66666666666666943.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000402622+114326_346132.66666666666666943.0TransmembraneHelical%3B Name%3DSegment S6
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000403813+113126_146132.66666666666666924.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000403813+113157_177132.66666666666666924.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000403813+113201_221132.66666666666666924.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000403813+113230_252132.66666666666666924.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000403813+113267_287132.66666666666666924.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000403813+113326_346132.66666666666666924.0TransmembraneHelical%3B Name%3DSegment S6
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000414165+112126_146132.66666666666666823.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000414165+112157_177132.66666666666666823.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000414165+112201_221132.66666666666666823.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000414165+112230_252132.66666666666666823.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000414165+112267_287132.66666666666666823.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNQ5chr6:73332315chr2:29498362ENST00000414165+112326_346132.66666666666666823.0TransmembraneHelical%3B Name%3DSegment S6
TgeneALKchr6:73332315chr2:29498362ENST00000389048829264_427605.66666666666661621.0DomainMAM 1
TgeneALKchr6:73332315chr2:29498362ENST00000389048829437_473605.66666666666661621.0DomainNote=LDL-receptor class A
TgeneALKchr6:73332315chr2:29498362ENST00000389048829478_636605.66666666666661621.0DomainMAM 2
TgeneALKchr6:73332315chr2:29498362ENST0000038904882919_1038605.66666666666661621.0Topological domainExtracellular


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KCNQ5
ALKall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to KCNQ5-ALK


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KCNQ5-ALK


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneALKC0007131Non-Small Cell Lung Carcinoma28CGI;CTD_human
TgeneALKC0027819Neuroblastoma13CGI;CTD_human;ORPHANET
TgeneALKC0152013Adenocarcinoma of lung (disorder)8CGI;CTD_human
TgeneALKC2751681NEUROBLASTOMA, SUSCEPTIBILITY TO, 38CLINGEN;UNIPROT
TgeneALKC0206180Ki-1+ Anaplastic Large Cell Lymphoma6CGI;CTD_human
TgeneALKC0334121Inflammatory Myofibroblastic Tumor4CGI;CTD_human;ORPHANET
TgeneALKC0018199Granuloma, Plasma Cell3CTD_human
TgeneALKC0007621Neoplastic Cell Transformation2CTD_human
TgeneALKC0027627Neoplasm Metastasis2CTD_human
TgeneALKC0238463Papillary thyroid carcinoma2ORPHANET
TgeneALKC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneALKC0006118Brain Neoplasms1CGI;CTD_human
TgeneALKC0006142Malignant neoplasm of breast1CTD_human
TgeneALKC0007134Renal Cell Carcinoma1CTD_human
TgeneALKC0011570Mental Depression1PSYGENET
TgeneALKC0011581Depressive disorder1PSYGENET
TgeneALKC0027643Neoplasm Recurrence, Local1CTD_human
TgeneALKC0036341Schizophrenia1PSYGENET
TgeneALKC0079744Diffuse Large B-Cell Lymphoma1CTD_human
TgeneALKC0085269Plasma Cell Granuloma, Pulmonary1CTD_human
TgeneALKC0153633Malignant neoplasm of brain1CGI;CTD_human
TgeneALKC0278601Inflammatory Breast Carcinoma1CTD_human
TgeneALKC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
TgeneALKC0496899Benign neoplasm of brain, unspecified1CTD_human
TgeneALKC0678222Breast Carcinoma1CTD_human
TgeneALKC0750974Brain Tumor, Primary1CTD_human
TgeneALKC0750977Recurrent Brain Neoplasm1CTD_human
TgeneALKC0750979Primary malignant neoplasm of brain1CTD_human
TgeneALKC1257931Mammary Neoplasms, Human1CTD_human
TgeneALKC1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneALKC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneALKC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneALKC1306837Papillary Renal Cell Carcinoma1CTD_human
TgeneALKC1332079Anaplastic Large Cell Lymphoma, ALK-Positive1ORPHANET
TgeneALKC1458155Mammary Neoplasms1CTD_human
TgeneALKC1527390Neoplasms, Intracranial1CTD_human
TgeneALKC2931189Neural crest tumor1ORPHANET
TgeneALKC3899155hereditary neuroblastoma1GENOMICS_ENGLAND
TgeneALKC4704874Mammary Carcinoma, Human1CTD_human