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Fusion Protein:KCNQ5-ALK |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: KCNQ5-ALK | FusionPDB ID: 41572 | FusionGDB2.0 ID: 41572 | Hgene | Tgene | Gene symbol | KCNQ5 | ALK | Gene ID | 56479 | 238 |
Gene name | potassium voltage-gated channel subfamily Q member 5 | ALK receptor tyrosine kinase | |
Synonyms | Kv7.5|MRD46 | CD246|NBLST3 | |
Cytomap | 6q13 | 2p23.2-p23.1 | |
Type of gene | protein-coding | protein-coding | |
Description | potassium voltage-gated channel subfamily KQT member 5KQT-like 5potassium channel proteinpotassium channel subunit alpha KvLQT5potassium channel, voltage gated KQT-like subfamily Q, member 5voltage-gated potassium channel subunit Kv7.5 | ALK tyrosine kinase receptorCD246 antigenanaplastic lymphoma receptor tyrosine kinasemutant anaplastic lymphoma kinase | |
Modification date | 20200313 | 20200329 | |
UniProtAcc | Q9NR82 | Q96BT7 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000342056, ENST00000355194, ENST00000355635, ENST00000370392, ENST00000370398, ENST00000402622, ENST00000403813, ENST00000414165, | ENST00000431873, ENST00000498037, ENST00000389048, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 8 X 7 X 4=224 | 56 X 74 X 20=82880 |
# samples | 8 | 57 | |
** MAII score | log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(57/82880*10)=-7.18391827352181 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: KCNQ5 [Title/Abstract] AND ALK [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | KCNQ5(73332315)-ALK(29498362), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | KCNQ5-ALK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KCNQ5-ALK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KCNQ5-ALK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KCNQ5-ALK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | KCNQ5 | GO:0071805 | potassium ion transmembrane transport | 10787416|11159685 |
Tgene | ALK | GO:0016310 | phosphorylation | 9174053 |
Tgene | ALK | GO:0046777 | protein autophosphorylation | 9174053 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | SKCM | TCGA-EB-A6QY-01A | KCNQ5 | chr6 | 73332315 | - | ALK | chr2 | 29498362 | - |
ChimerDB4 | SKCM | TCGA-EB-A6QY-01A | KCNQ5 | chr6 | 73332315 | + | ALK | chr2 | 29498362 | - |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000342056 | KCNQ5 | chr6 | 73332315 | + | ENST00000389048 | ALK | chr2 | 29498362 | - | 4292 | 796 | 398 | 3841 | 1147 |
ENST00000355194 | KCNQ5 | chr6 | 73332315 | + | ENST00000389048 | ALK | chr2 | 29498362 | - | 4235 | 739 | 347 | 3784 | 1145 |
ENST00000370398 | KCNQ5 | chr6 | 73332315 | + | ENST00000389048 | ALK | chr2 | 29498362 | - | 4003 | 507 | 109 | 3552 | 1147 |
ENST00000370392 | KCNQ5 | chr6 | 73332315 | + | ENST00000389048 | ALK | chr2 | 29498362 | - | 3978 | 482 | 84 | 3527 | 1147 |
ENST00000355635 | KCNQ5 | chr6 | 73332315 | + | ENST00000389048 | ALK | chr2 | 29498362 | - | 3894 | 398 | 0 | 3443 | 1147 |
ENST00000414165 | KCNQ5 | chr6 | 73332315 | + | ENST00000389048 | ALK | chr2 | 29498362 | - | 3894 | 398 | 0 | 3443 | 1147 |
ENST00000402622 | KCNQ5 | chr6 | 73332315 | + | ENST00000389048 | ALK | chr2 | 29498362 | - | 3894 | 398 | 0 | 3443 | 1147 |
ENST00000403813 | KCNQ5 | chr6 | 73332315 | + | ENST00000389048 | ALK | chr2 | 29498362 | - | 3894 | 398 | 0 | 3443 | 1147 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000342056 | ENST00000389048 | KCNQ5 | chr6 | 73332315 | + | ALK | chr2 | 29498362 | - | 0.001185336 | 0.9988147 |
ENST00000355194 | ENST00000389048 | KCNQ5 | chr6 | 73332315 | + | ALK | chr2 | 29498362 | - | 0.001240512 | 0.9987595 |
ENST00000370398 | ENST00000389048 | KCNQ5 | chr6 | 73332315 | + | ALK | chr2 | 29498362 | - | 0.000913378 | 0.9990866 |
ENST00000370392 | ENST00000389048 | KCNQ5 | chr6 | 73332315 | + | ALK | chr2 | 29498362 | - | 0.000885868 | 0.9991141 |
ENST00000355635 | ENST00000389048 | KCNQ5 | chr6 | 73332315 | + | ALK | chr2 | 29498362 | - | 0.000754243 | 0.99924576 |
ENST00000414165 | ENST00000389048 | KCNQ5 | chr6 | 73332315 | + | ALK | chr2 | 29498362 | - | 0.000754243 | 0.99924576 |
ENST00000402622 | ENST00000389048 | KCNQ5 | chr6 | 73332315 | + | ALK | chr2 | 29498362 | - | 0.000754243 | 0.99924576 |
ENST00000403813 | ENST00000389048 | KCNQ5 | chr6 | 73332315 | + | ALK | chr2 | 29498362 | - | 0.000754243 | 0.99924576 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >41572_41572_1_KCNQ5-ALK_KCNQ5_chr6_73332315_ENST00000342056_ALK_chr2_29498362_ENST00000389048_length(amino acids)=1147AA_BP=133 MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSR NLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAG GKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDG VPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGG GGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTV LAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTS SISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRF ILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYY RKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDR PNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISV RVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGA -------------------------------------------------------------- >41572_41572_2_KCNQ5-ALK_KCNQ5_chr6_73332315_ENST00000355194_ALK_chr2_29498362_ENST00000389048_length(amino acids)=1145AA_BP=131 MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNL FERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGK GGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVP VPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGG GGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLA EDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSI SDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFIL LELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRK GGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPN FAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRV PRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASL -------------------------------------------------------------- >41572_41572_3_KCNQ5-ALK_KCNQ5_chr6_73332315_ENST00000355635_ALK_chr2_29498362_ENST00000389048_length(amino acids)=1147AA_BP=133 MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSR NLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAG GKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDG VPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGG GGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTV LAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTS SISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRF ILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYY RKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDR PNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISV RVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGA -------------------------------------------------------------- >41572_41572_4_KCNQ5-ALK_KCNQ5_chr6_73332315_ENST00000370392_ALK_chr2_29498362_ENST00000389048_length(amino acids)=1147AA_BP=133 MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSR NLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAG GKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDG VPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGG GGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTV LAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTS SISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRF ILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYY RKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDR PNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISV RVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGA -------------------------------------------------------------- >41572_41572_5_KCNQ5-ALK_KCNQ5_chr6_73332315_ENST00000370398_ALK_chr2_29498362_ENST00000389048_length(amino acids)=1147AA_BP=133 MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSR NLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAG GKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDG VPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGG GGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTV LAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTS SISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRF ILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYY RKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDR PNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISV RVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGA -------------------------------------------------------------- >41572_41572_6_KCNQ5-ALK_KCNQ5_chr6_73332315_ENST00000402622_ALK_chr2_29498362_ENST00000389048_length(amino acids)=1147AA_BP=133 MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSR NLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAG GKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDG VPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGG GGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTV LAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTS SISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRF ILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYY RKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDR PNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISV RVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGA -------------------------------------------------------------- >41572_41572_7_KCNQ5-ALK_KCNQ5_chr6_73332315_ENST00000403813_ALK_chr2_29498362_ENST00000389048_length(amino acids)=1147AA_BP=133 MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSR NLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAG GKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDG VPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGG GGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTV LAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTS SISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRF ILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYY RKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDR PNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISV RVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGA -------------------------------------------------------------- >41572_41572_8_KCNQ5-ALK_KCNQ5_chr6_73332315_ENST00000414165_ALK_chr2_29498362_ENST00000389048_length(amino acids)=1147AA_BP=133 MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSR NLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAG GKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDG VPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGG GGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTV LAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTS SISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRF ILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYY RKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDR PNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISV RVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGA -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:73332315/chr2:29498362) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
KCNQ5 | ALK |
FUNCTION: Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. As the native M-channel, the potassium channel composed of KCNQ3 and KCNQ5 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1. {ECO:0000269|PubMed:10787416, ECO:0000269|PubMed:11159685, ECO:0000269|PubMed:28669405}. | FUNCTION: Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323, PubMed:31079898). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182). {ECO:0000269|PubMed:19293182, ECO:0000269|PubMed:20123966, ECO:0000269|PubMed:20308323, ECO:0000269|PubMed:21285950, ECO:0000269|PubMed:31079898}. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370392 | + | 1 | 9 | 1_125 | 132.66666666666666 | 428.0 | Topological domain | Cytoplasmic |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370398 | + | 1 | 14 | 1_125 | 132.66666666666666 | 933.0 | Topological domain | Cytoplasmic |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000402622 | + | 1 | 14 | 1_125 | 132.66666666666666 | 943.0 | Topological domain | Cytoplasmic |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000403813 | + | 1 | 13 | 1_125 | 132.66666666666666 | 924.0 | Topological domain | Cytoplasmic |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000414165 | + | 1 | 12 | 1_125 | 132.66666666666666 | 823.0 | Topological domain | Cytoplasmic |
Tgene | ALK | chr6:73332315 | chr2:29498362 | ENST00000389048 | 8 | 29 | 816_940 | 605.6666666666666 | 1621.0 | Compositional bias | Note=Gly-rich | |
Tgene | ALK | chr6:73332315 | chr2:29498362 | ENST00000389048 | 8 | 29 | 1116_1392 | 605.6666666666666 | 1621.0 | Domain | Protein kinase | |
Tgene | ALK | chr6:73332315 | chr2:29498362 | ENST00000389048 | 8 | 29 | 1197_1199 | 605.6666666666666 | 1621.0 | Region | Note=Inhibitor binding | |
Tgene | ALK | chr6:73332315 | chr2:29498362 | ENST00000389048 | 8 | 29 | 1060_1620 | 605.6666666666666 | 1621.0 | Topological domain | Cytoplasmic | |
Tgene | ALK | chr6:73332315 | chr2:29498362 | ENST00000389048 | 8 | 29 | 1039_1059 | 605.6666666666666 | 1621.0 | Transmembrane | Helical |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370392 | + | 1 | 9 | 299_319 | 132.66666666666666 | 428.0 | Intramembrane | Pore-forming%3B Name%3DSegment H5 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370398 | + | 1 | 14 | 299_319 | 132.66666666666666 | 933.0 | Intramembrane | Pore-forming%3B Name%3DSegment H5 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000402622 | + | 1 | 14 | 299_319 | 132.66666666666666 | 943.0 | Intramembrane | Pore-forming%3B Name%3DSegment H5 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000403813 | + | 1 | 13 | 299_319 | 132.66666666666666 | 924.0 | Intramembrane | Pore-forming%3B Name%3DSegment H5 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000414165 | + | 1 | 12 | 299_319 | 132.66666666666666 | 823.0 | Intramembrane | Pore-forming%3B Name%3DSegment H5 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370392 | + | 1 | 9 | 311_316 | 132.66666666666666 | 428.0 | Motif | Selectivity filter |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370398 | + | 1 | 14 | 311_316 | 132.66666666666666 | 933.0 | Motif | Selectivity filter |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000402622 | + | 1 | 14 | 311_316 | 132.66666666666666 | 943.0 | Motif | Selectivity filter |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000403813 | + | 1 | 13 | 311_316 | 132.66666666666666 | 924.0 | Motif | Selectivity filter |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000414165 | + | 1 | 12 | 311_316 | 132.66666666666666 | 823.0 | Motif | Selectivity filter |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370392 | + | 1 | 9 | 147_156 | 132.66666666666666 | 428.0 | Topological domain | Extracellular |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370392 | + | 1 | 9 | 178_200 | 132.66666666666666 | 428.0 | Topological domain | Cytoplasmic |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370392 | + | 1 | 9 | 222_229 | 132.66666666666666 | 428.0 | Topological domain | Extracellular |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370392 | + | 1 | 9 | 253_266 | 132.66666666666666 | 428.0 | Topological domain | Cytoplasmic |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370392 | + | 1 | 9 | 288_298 | 132.66666666666666 | 428.0 | Topological domain | Extracellular |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370392 | + | 1 | 9 | 320_325 | 132.66666666666666 | 428.0 | Topological domain | Extracellular |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370392 | + | 1 | 9 | 347_932 | 132.66666666666666 | 428.0 | Topological domain | Cytoplasmic |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370398 | + | 1 | 14 | 147_156 | 132.66666666666666 | 933.0 | Topological domain | Extracellular |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370398 | + | 1 | 14 | 178_200 | 132.66666666666666 | 933.0 | Topological domain | Cytoplasmic |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370398 | + | 1 | 14 | 222_229 | 132.66666666666666 | 933.0 | Topological domain | Extracellular |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370398 | + | 1 | 14 | 253_266 | 132.66666666666666 | 933.0 | Topological domain | Cytoplasmic |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370398 | + | 1 | 14 | 288_298 | 132.66666666666666 | 933.0 | Topological domain | Extracellular |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370398 | + | 1 | 14 | 320_325 | 132.66666666666666 | 933.0 | Topological domain | Extracellular |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370398 | + | 1 | 14 | 347_932 | 132.66666666666666 | 933.0 | Topological domain | Cytoplasmic |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000402622 | + | 1 | 14 | 147_156 | 132.66666666666666 | 943.0 | Topological domain | Extracellular |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000402622 | + | 1 | 14 | 178_200 | 132.66666666666666 | 943.0 | Topological domain | Cytoplasmic |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000402622 | + | 1 | 14 | 222_229 | 132.66666666666666 | 943.0 | Topological domain | Extracellular |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000402622 | + | 1 | 14 | 253_266 | 132.66666666666666 | 943.0 | Topological domain | Cytoplasmic |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000402622 | + | 1 | 14 | 288_298 | 132.66666666666666 | 943.0 | Topological domain | Extracellular |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000402622 | + | 1 | 14 | 320_325 | 132.66666666666666 | 943.0 | Topological domain | Extracellular |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000402622 | + | 1 | 14 | 347_932 | 132.66666666666666 | 943.0 | Topological domain | Cytoplasmic |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000403813 | + | 1 | 13 | 147_156 | 132.66666666666666 | 924.0 | Topological domain | Extracellular |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000403813 | + | 1 | 13 | 178_200 | 132.66666666666666 | 924.0 | Topological domain | Cytoplasmic |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000403813 | + | 1 | 13 | 222_229 | 132.66666666666666 | 924.0 | Topological domain | Extracellular |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000403813 | + | 1 | 13 | 253_266 | 132.66666666666666 | 924.0 | Topological domain | Cytoplasmic |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000403813 | + | 1 | 13 | 288_298 | 132.66666666666666 | 924.0 | Topological domain | Extracellular |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000403813 | + | 1 | 13 | 320_325 | 132.66666666666666 | 924.0 | Topological domain | Extracellular |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000403813 | + | 1 | 13 | 347_932 | 132.66666666666666 | 924.0 | Topological domain | Cytoplasmic |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000414165 | + | 1 | 12 | 147_156 | 132.66666666666666 | 823.0 | Topological domain | Extracellular |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000414165 | + | 1 | 12 | 178_200 | 132.66666666666666 | 823.0 | Topological domain | Cytoplasmic |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000414165 | + | 1 | 12 | 222_229 | 132.66666666666666 | 823.0 | Topological domain | Extracellular |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000414165 | + | 1 | 12 | 253_266 | 132.66666666666666 | 823.0 | Topological domain | Cytoplasmic |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000414165 | + | 1 | 12 | 288_298 | 132.66666666666666 | 823.0 | Topological domain | Extracellular |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000414165 | + | 1 | 12 | 320_325 | 132.66666666666666 | 823.0 | Topological domain | Extracellular |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000414165 | + | 1 | 12 | 347_932 | 132.66666666666666 | 823.0 | Topological domain | Cytoplasmic |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370392 | + | 1 | 9 | 126_146 | 132.66666666666666 | 428.0 | Transmembrane | Helical%3B Name%3DSegment S1 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370392 | + | 1 | 9 | 157_177 | 132.66666666666666 | 428.0 | Transmembrane | Helical%3B Name%3DSegment S2 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370392 | + | 1 | 9 | 201_221 | 132.66666666666666 | 428.0 | Transmembrane | Helical%3B Name%3DSegment S3 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370392 | + | 1 | 9 | 230_252 | 132.66666666666666 | 428.0 | Transmembrane | Helical%3B Voltage-sensor%3B Name%3DSegment S4 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370392 | + | 1 | 9 | 267_287 | 132.66666666666666 | 428.0 | Transmembrane | Helical%3B Name%3DSegment S5 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370392 | + | 1 | 9 | 326_346 | 132.66666666666666 | 428.0 | Transmembrane | Helical%3B Name%3DSegment S6 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370398 | + | 1 | 14 | 126_146 | 132.66666666666666 | 933.0 | Transmembrane | Helical%3B Name%3DSegment S1 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370398 | + | 1 | 14 | 157_177 | 132.66666666666666 | 933.0 | Transmembrane | Helical%3B Name%3DSegment S2 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370398 | + | 1 | 14 | 201_221 | 132.66666666666666 | 933.0 | Transmembrane | Helical%3B Name%3DSegment S3 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370398 | + | 1 | 14 | 230_252 | 132.66666666666666 | 933.0 | Transmembrane | Helical%3B Voltage-sensor%3B Name%3DSegment S4 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370398 | + | 1 | 14 | 267_287 | 132.66666666666666 | 933.0 | Transmembrane | Helical%3B Name%3DSegment S5 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000370398 | + | 1 | 14 | 326_346 | 132.66666666666666 | 933.0 | Transmembrane | Helical%3B Name%3DSegment S6 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000402622 | + | 1 | 14 | 126_146 | 132.66666666666666 | 943.0 | Transmembrane | Helical%3B Name%3DSegment S1 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000402622 | + | 1 | 14 | 157_177 | 132.66666666666666 | 943.0 | Transmembrane | Helical%3B Name%3DSegment S2 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000402622 | + | 1 | 14 | 201_221 | 132.66666666666666 | 943.0 | Transmembrane | Helical%3B Name%3DSegment S3 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000402622 | + | 1 | 14 | 230_252 | 132.66666666666666 | 943.0 | Transmembrane | Helical%3B Voltage-sensor%3B Name%3DSegment S4 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000402622 | + | 1 | 14 | 267_287 | 132.66666666666666 | 943.0 | Transmembrane | Helical%3B Name%3DSegment S5 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000402622 | + | 1 | 14 | 326_346 | 132.66666666666666 | 943.0 | Transmembrane | Helical%3B Name%3DSegment S6 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000403813 | + | 1 | 13 | 126_146 | 132.66666666666666 | 924.0 | Transmembrane | Helical%3B Name%3DSegment S1 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000403813 | + | 1 | 13 | 157_177 | 132.66666666666666 | 924.0 | Transmembrane | Helical%3B Name%3DSegment S2 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000403813 | + | 1 | 13 | 201_221 | 132.66666666666666 | 924.0 | Transmembrane | Helical%3B Name%3DSegment S3 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000403813 | + | 1 | 13 | 230_252 | 132.66666666666666 | 924.0 | Transmembrane | Helical%3B Voltage-sensor%3B Name%3DSegment S4 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000403813 | + | 1 | 13 | 267_287 | 132.66666666666666 | 924.0 | Transmembrane | Helical%3B Name%3DSegment S5 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000403813 | + | 1 | 13 | 326_346 | 132.66666666666666 | 924.0 | Transmembrane | Helical%3B Name%3DSegment S6 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000414165 | + | 1 | 12 | 126_146 | 132.66666666666666 | 823.0 | Transmembrane | Helical%3B Name%3DSegment S1 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000414165 | + | 1 | 12 | 157_177 | 132.66666666666666 | 823.0 | Transmembrane | Helical%3B Name%3DSegment S2 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000414165 | + | 1 | 12 | 201_221 | 132.66666666666666 | 823.0 | Transmembrane | Helical%3B Name%3DSegment S3 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000414165 | + | 1 | 12 | 230_252 | 132.66666666666666 | 823.0 | Transmembrane | Helical%3B Voltage-sensor%3B Name%3DSegment S4 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000414165 | + | 1 | 12 | 267_287 | 132.66666666666666 | 823.0 | Transmembrane | Helical%3B Name%3DSegment S5 |
Hgene | KCNQ5 | chr6:73332315 | chr2:29498362 | ENST00000414165 | + | 1 | 12 | 326_346 | 132.66666666666666 | 823.0 | Transmembrane | Helical%3B Name%3DSegment S6 |
Tgene | ALK | chr6:73332315 | chr2:29498362 | ENST00000389048 | 8 | 29 | 264_427 | 605.6666666666666 | 1621.0 | Domain | MAM 1 | |
Tgene | ALK | chr6:73332315 | chr2:29498362 | ENST00000389048 | 8 | 29 | 437_473 | 605.6666666666666 | 1621.0 | Domain | Note=LDL-receptor class A | |
Tgene | ALK | chr6:73332315 | chr2:29498362 | ENST00000389048 | 8 | 29 | 478_636 | 605.6666666666666 | 1621.0 | Domain | MAM 2 | |
Tgene | ALK | chr6:73332315 | chr2:29498362 | ENST00000389048 | 8 | 29 | 19_1038 | 605.6666666666666 | 1621.0 | Topological domain | Extracellular |
Top |
Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
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Gene | STRING network |
KCNQ5 | |
ALK | ![]() |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs to KCNQ5-ALK |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to KCNQ5-ALK |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ALK | C0007131 | Non-Small Cell Lung Carcinoma | 28 | CGI;CTD_human |
Tgene | ALK | C0027819 | Neuroblastoma | 13 | CGI;CTD_human;ORPHANET |
Tgene | ALK | C0152013 | Adenocarcinoma of lung (disorder) | 8 | CGI;CTD_human |
Tgene | ALK | C2751681 | NEUROBLASTOMA, SUSCEPTIBILITY TO, 3 | 8 | CLINGEN;UNIPROT |
Tgene | ALK | C0206180 | Ki-1+ Anaplastic Large Cell Lymphoma | 6 | CGI;CTD_human |
Tgene | ALK | C0334121 | Inflammatory Myofibroblastic Tumor | 4 | CGI;CTD_human;ORPHANET |
Tgene | ALK | C0018199 | Granuloma, Plasma Cell | 3 | CTD_human |
Tgene | ALK | C0007621 | Neoplastic Cell Transformation | 2 | CTD_human |
Tgene | ALK | C0027627 | Neoplasm Metastasis | 2 | CTD_human |
Tgene | ALK | C0238463 | Papillary thyroid carcinoma | 2 | ORPHANET |
Tgene | ALK | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Tgene | ALK | C0006118 | Brain Neoplasms | 1 | CGI;CTD_human |
Tgene | ALK | C0006142 | Malignant neoplasm of breast | 1 | CTD_human |
Tgene | ALK | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Tgene | ALK | C0011570 | Mental Depression | 1 | PSYGENET |
Tgene | ALK | C0011581 | Depressive disorder | 1 | PSYGENET |
Tgene | ALK | C0027643 | Neoplasm Recurrence, Local | 1 | CTD_human |
Tgene | ALK | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | ALK | C0079744 | Diffuse Large B-Cell Lymphoma | 1 | CTD_human |
Tgene | ALK | C0085269 | Plasma Cell Granuloma, Pulmonary | 1 | CTD_human |
Tgene | ALK | C0153633 | Malignant neoplasm of brain | 1 | CGI;CTD_human |
Tgene | ALK | C0278601 | Inflammatory Breast Carcinoma | 1 | CTD_human |
Tgene | ALK | C0279702 | Conventional (Clear Cell) Renal Cell Carcinoma | 1 | CTD_human |
Tgene | ALK | C0496899 | Benign neoplasm of brain, unspecified | 1 | CTD_human |
Tgene | ALK | C0678222 | Breast Carcinoma | 1 | CTD_human |
Tgene | ALK | C0750974 | Brain Tumor, Primary | 1 | CTD_human |
Tgene | ALK | C0750977 | Recurrent Brain Neoplasm | 1 | CTD_human |
Tgene | ALK | C0750979 | Primary malignant neoplasm of brain | 1 | CTD_human |
Tgene | ALK | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
Tgene | ALK | C1266042 | Chromophobe Renal Cell Carcinoma | 1 | CTD_human |
Tgene | ALK | C1266043 | Sarcomatoid Renal Cell Carcinoma | 1 | CTD_human |
Tgene | ALK | C1266044 | Collecting Duct Carcinoma of the Kidney | 1 | CTD_human |
Tgene | ALK | C1306837 | Papillary Renal Cell Carcinoma | 1 | CTD_human |
Tgene | ALK | C1332079 | Anaplastic Large Cell Lymphoma, ALK-Positive | 1 | ORPHANET |
Tgene | ALK | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | ALK | C1527390 | Neoplasms, Intracranial | 1 | CTD_human |
Tgene | ALK | C2931189 | Neural crest tumor | 1 | ORPHANET |
Tgene | ALK | C3899155 | hereditary neuroblastoma | 1 | GENOMICS_ENGLAND |
Tgene | ALK | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |