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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:KCNQ5-RNF217

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KCNQ5-RNF217
FusionPDB ID: 41579
FusionGDB2.0 ID: 41579
HgeneTgene
Gene symbol

KCNQ5

RNF217

Gene ID

56479

154214

Gene namepotassium voltage-gated channel subfamily Q member 5ring finger protein 217
SynonymsKv7.5|MRD46C6orf172|IBRDC1|OSTL|dJ84N20.1
Cytomap

6q13

6q22.31

Type of geneprotein-codingprotein-coding
Descriptionpotassium voltage-gated channel subfamily KQT member 5KQT-like 5potassium channel proteinpotassium channel subunit alpha KvLQT5potassium channel, voltage gated KQT-like subfamily Q, member 5voltage-gated potassium channel subunit Kv7.5probable E3 ubiquitin-protein ligase RNF217IBR domain containing 1opposite STL
Modification date2020031320200313
UniProtAcc

Q9NR82

.
Ensembl transtripts involved in fusion geneENST idsENST00000342056, ENST00000355194, 
ENST00000355635, ENST00000370392, 
ENST00000370398, ENST00000402622, 
ENST00000403813, ENST00000414165, 
ENST00000275184, ENST00000359704, 
ENST00000368414, ENST00000454842, 
ENST00000521654, ENST00000560949, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 7 X 4=2245 X 6 X 6=180
# samples 811
** MAII scorelog2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/180*10)=-0.710493382805015
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: KCNQ5 [Title/Abstract] AND RNF217 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KCNQ5(73713721)-RNF217(125397803), # samples:2
Anticipated loss of major functional domain due to fusion event.KCNQ5-RNF217 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KCNQ5-RNF217 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KCNQ5-RNF217 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KCNQ5-RNF217 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKCNQ5

GO:0071805

potassium ion transmembrane transport

10787416|11159685


check buttonFusion gene breakpoints across KCNQ5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RNF217 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-FS-A1Z0-06AKCNQ5chr6

73713721

+RNF217chr6

125397803

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000342056KCNQ5chr673713721+ENST00000521654RNF217chr6125397803+109318873981234278
ENST00000342056KCNQ5chr673713721+ENST00000560949RNF217chr6125397803+20168873981234278
ENST00000355194KCNQ5chr673713721+ENST00000521654RNF217chr6125397803+108808363471183278
ENST00000355194KCNQ5chr673713721+ENST00000560949RNF217chr6125397803+19658363471183278
ENST00000370398KCNQ5chr673713721+ENST00000521654RNF217chr6125397803+10642598109945278
ENST00000370398KCNQ5chr673713721+ENST00000560949RNF217chr6125397803+1727598109945278
ENST00000370392KCNQ5chr673713721+ENST00000521654RNF217chr6125397803+1061757384920278
ENST00000370392KCNQ5chr673713721+ENST00000560949RNF217chr6125397803+170257384920278
ENST00000355635KCNQ5chr673713721+ENST00000521654RNF217chr6125397803+105334890836278
ENST00000355635KCNQ5chr673713721+ENST00000560949RNF217chr6125397803+16184890836278
ENST00000414165KCNQ5chr673713721+ENST00000521654RNF217chr6125397803+105334890836278
ENST00000414165KCNQ5chr673713721+ENST00000560949RNF217chr6125397803+16184890836278
ENST00000402622KCNQ5chr673713721+ENST00000521654RNF217chr6125397803+105334890836278
ENST00000402622KCNQ5chr673713721+ENST00000560949RNF217chr6125397803+16184890836278
ENST00000403813KCNQ5chr673713721+ENST00000521654RNF217chr6125397803+105334890836278
ENST00000403813KCNQ5chr673713721+ENST00000560949RNF217chr6125397803+16184890836278

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000342056ENST00000521654KCNQ5chr673713721+RNF217chr6125397803+0.0148024360.9851976
ENST00000342056ENST00000560949KCNQ5chr673713721+RNF217chr6125397803+0.103249860.89675015
ENST00000355194ENST00000521654KCNQ5chr673713721+RNF217chr6125397803+0.0162142030.9837858
ENST00000355194ENST00000560949KCNQ5chr673713721+RNF217chr6125397803+0.116333540.8836665
ENST00000370398ENST00000521654KCNQ5chr673713721+RNF217chr6125397803+0.0137372930.9862627
ENST00000370398ENST00000560949KCNQ5chr673713721+RNF217chr6125397803+0.070720960.92927897
ENST00000370392ENST00000521654KCNQ5chr673713721+RNF217chr6125397803+0.013790370.9862096
ENST00000370392ENST00000560949KCNQ5chr673713721+RNF217chr6125397803+0.0652259740.93477404
ENST00000355635ENST00000521654KCNQ5chr673713721+RNF217chr6125397803+0.0137660920.98623395
ENST00000355635ENST00000560949KCNQ5chr673713721+RNF217chr6125397803+0.0526465480.9473534
ENST00000414165ENST00000521654KCNQ5chr673713721+RNF217chr6125397803+0.0137660920.98623395
ENST00000414165ENST00000560949KCNQ5chr673713721+RNF217chr6125397803+0.0526465480.9473534
ENST00000402622ENST00000521654KCNQ5chr673713721+RNF217chr6125397803+0.0137660920.98623395
ENST00000402622ENST00000560949KCNQ5chr673713721+RNF217chr6125397803+0.0526465480.9473534
ENST00000403813ENST00000521654KCNQ5chr673713721+RNF217chr6125397803+0.0137660920.98623395
ENST00000403813ENST00000560949KCNQ5chr673713721+RNF217chr6125397803+0.0526465480.9473534

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>41579_41579_1_KCNQ5-RNF217_KCNQ5_chr6_73713721_ENST00000342056_RNF217_chr6_125397803_ENST00000521654_length(amino acids)=278AA_BP=159
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILIHIQRTEGCDHMTCSQC
NTNFCYRCGERYRQLRFFGDHTSNLSIFGCKYRYLPERPHLRRLVRGSVCAGKLFIAPLIMVLGLALGAIAVVIGLFVFPIYCLCKKQRK

--------------------------------------------------------------

>41579_41579_2_KCNQ5-RNF217_KCNQ5_chr6_73713721_ENST00000342056_RNF217_chr6_125397803_ENST00000560949_length(amino acids)=278AA_BP=159
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILIHIQRTEGCDHMTCSQC
NTNFCYRCGERYRQLRFFGDHTSNLSIFGCKYRYLPERPHLRRLVRGSVCAGKLFIAPLIMVLGLALGAIAVVIGLFVFPIYCLCKKQRK

--------------------------------------------------------------

>41579_41579_3_KCNQ5-RNF217_KCNQ5_chr6_73713721_ENST00000355194_RNF217_chr6_125397803_ENST00000521654_length(amino acids)=278AA_BP=159
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLPVFGCLILSVFSTIPEHTKLASSCLLILIHIQRTEGCDHMTCSQC
NTNFCYRCGERYRQLRFFGDHTSNLSIFGCKYRYLPERPHLRRLVRGSVCAGKLFIAPLIMVLGLALGAIAVVIGLFVFPIYCLCKKQRK

--------------------------------------------------------------

>41579_41579_4_KCNQ5-RNF217_KCNQ5_chr6_73713721_ENST00000355194_RNF217_chr6_125397803_ENST00000560949_length(amino acids)=278AA_BP=159
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLPVFGCLILSVFSTIPEHTKLASSCLLILIHIQRTEGCDHMTCSQC
NTNFCYRCGERYRQLRFFGDHTSNLSIFGCKYRYLPERPHLRRLVRGSVCAGKLFIAPLIMVLGLALGAIAVVIGLFVFPIYCLCKKQRK

--------------------------------------------------------------

>41579_41579_5_KCNQ5-RNF217_KCNQ5_chr6_73713721_ENST00000355635_RNF217_chr6_125397803_ENST00000521654_length(amino acids)=278AA_BP=159
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILIHIQRTEGCDHMTCSQC
NTNFCYRCGERYRQLRFFGDHTSNLSIFGCKYRYLPERPHLRRLVRGSVCAGKLFIAPLIMVLGLALGAIAVVIGLFVFPIYCLCKKQRK

--------------------------------------------------------------

>41579_41579_6_KCNQ5-RNF217_KCNQ5_chr6_73713721_ENST00000355635_RNF217_chr6_125397803_ENST00000560949_length(amino acids)=278AA_BP=159
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILIHIQRTEGCDHMTCSQC
NTNFCYRCGERYRQLRFFGDHTSNLSIFGCKYRYLPERPHLRRLVRGSVCAGKLFIAPLIMVLGLALGAIAVVIGLFVFPIYCLCKKQRK

--------------------------------------------------------------

>41579_41579_7_KCNQ5-RNF217_KCNQ5_chr6_73713721_ENST00000370392_RNF217_chr6_125397803_ENST00000521654_length(amino acids)=278AA_BP=159
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILIHIQRTEGCDHMTCSQC
NTNFCYRCGERYRQLRFFGDHTSNLSIFGCKYRYLPERPHLRRLVRGSVCAGKLFIAPLIMVLGLALGAIAVVIGLFVFPIYCLCKKQRK

--------------------------------------------------------------

>41579_41579_8_KCNQ5-RNF217_KCNQ5_chr6_73713721_ENST00000370392_RNF217_chr6_125397803_ENST00000560949_length(amino acids)=278AA_BP=159
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILIHIQRTEGCDHMTCSQC
NTNFCYRCGERYRQLRFFGDHTSNLSIFGCKYRYLPERPHLRRLVRGSVCAGKLFIAPLIMVLGLALGAIAVVIGLFVFPIYCLCKKQRK

--------------------------------------------------------------

>41579_41579_9_KCNQ5-RNF217_KCNQ5_chr6_73713721_ENST00000370398_RNF217_chr6_125397803_ENST00000521654_length(amino acids)=278AA_BP=159
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILIHIQRTEGCDHMTCSQC
NTNFCYRCGERYRQLRFFGDHTSNLSIFGCKYRYLPERPHLRRLVRGSVCAGKLFIAPLIMVLGLALGAIAVVIGLFVFPIYCLCKKQRK

--------------------------------------------------------------

>41579_41579_10_KCNQ5-RNF217_KCNQ5_chr6_73713721_ENST00000370398_RNF217_chr6_125397803_ENST00000560949_length(amino acids)=278AA_BP=159
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILIHIQRTEGCDHMTCSQC
NTNFCYRCGERYRQLRFFGDHTSNLSIFGCKYRYLPERPHLRRLVRGSVCAGKLFIAPLIMVLGLALGAIAVVIGLFVFPIYCLCKKQRK

--------------------------------------------------------------

>41579_41579_11_KCNQ5-RNF217_KCNQ5_chr6_73713721_ENST00000402622_RNF217_chr6_125397803_ENST00000521654_length(amino acids)=278AA_BP=159
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILIHIQRTEGCDHMTCSQC
NTNFCYRCGERYRQLRFFGDHTSNLSIFGCKYRYLPERPHLRRLVRGSVCAGKLFIAPLIMVLGLALGAIAVVIGLFVFPIYCLCKKQRK

--------------------------------------------------------------

>41579_41579_12_KCNQ5-RNF217_KCNQ5_chr6_73713721_ENST00000402622_RNF217_chr6_125397803_ENST00000560949_length(amino acids)=278AA_BP=159
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILIHIQRTEGCDHMTCSQC
NTNFCYRCGERYRQLRFFGDHTSNLSIFGCKYRYLPERPHLRRLVRGSVCAGKLFIAPLIMVLGLALGAIAVVIGLFVFPIYCLCKKQRK

--------------------------------------------------------------

>41579_41579_13_KCNQ5-RNF217_KCNQ5_chr6_73713721_ENST00000403813_RNF217_chr6_125397803_ENST00000521654_length(amino acids)=278AA_BP=159
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILIHIQRTEGCDHMTCSQC
NTNFCYRCGERYRQLRFFGDHTSNLSIFGCKYRYLPERPHLRRLVRGSVCAGKLFIAPLIMVLGLALGAIAVVIGLFVFPIYCLCKKQRK

--------------------------------------------------------------

>41579_41579_14_KCNQ5-RNF217_KCNQ5_chr6_73713721_ENST00000403813_RNF217_chr6_125397803_ENST00000560949_length(amino acids)=278AA_BP=159
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILIHIQRTEGCDHMTCSQC
NTNFCYRCGERYRQLRFFGDHTSNLSIFGCKYRYLPERPHLRRLVRGSVCAGKLFIAPLIMVLGLALGAIAVVIGLFVFPIYCLCKKQRK

--------------------------------------------------------------

>41579_41579_15_KCNQ5-RNF217_KCNQ5_chr6_73713721_ENST00000414165_RNF217_chr6_125397803_ENST00000521654_length(amino acids)=278AA_BP=159
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILIHIQRTEGCDHMTCSQC
NTNFCYRCGERYRQLRFFGDHTSNLSIFGCKYRYLPERPHLRRLVRGSVCAGKLFIAPLIMVLGLALGAIAVVIGLFVFPIYCLCKKQRK

--------------------------------------------------------------

>41579_41579_16_KCNQ5-RNF217_KCNQ5_chr6_73713721_ENST00000414165_RNF217_chr6_125397803_ENST00000560949_length(amino acids)=278AA_BP=159
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILIHIQRTEGCDHMTCSQC
NTNFCYRCGERYRQLRFFGDHTSNLSIFGCKYRYLPERPHLRRLVRGSVCAGKLFIAPLIMVLGLALGAIAVVIGLFVFPIYCLCKKQRK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:73713721/chr6:125397803)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KCNQ5

Q9NR82

.
FUNCTION: Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. As the native M-channel, the potassium channel composed of KCNQ3 and KCNQ5 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1. {ECO:0000269|PubMed:10787416, ECO:0000269|PubMed:11159685, ECO:0000269|PubMed:28669405}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370392+29147_156163.0428.0Topological domainExtracellular
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370392+291_125163.0428.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370398+214147_156163.0933.0Topological domainExtracellular
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370398+2141_125163.0933.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000402622+214147_156163.0943.0Topological domainExtracellular
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000402622+2141_125163.0943.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000403813+213147_156163.0924.0Topological domainExtracellular
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000403813+2131_125163.0924.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000414165+212147_156163.0823.0Topological domainExtracellular
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000414165+2121_125163.0823.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370392+29126_146163.0428.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370398+214126_146163.0933.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000402622+214126_146163.0943.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000403813+213126_146163.0924.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000414165+212126_146163.0823.0TransmembraneHelical%3B Name%3DSegment S1
TgeneRNF217chr6:73713721chr6:125397803ENST0000035970449259_478135.0276.0RegionTRIAD supradomain
TgeneRNF217chr6:73713721chr6:125397803ENST0000035970449503_523135.0276.0TransmembraneHelical
TgeneRNF217chr6:73713721chr6:125397803ENST0000035970449263_309135.0276.0Zinc fingerRING-type 1
TgeneRNF217chr6:73713721chr6:125397803ENST0000035970449328_396135.0276.0Zinc fingerIBR-type
TgeneRNF217chr6:73713721chr6:125397803ENST0000035970449423_452135.0276.0Zinc fingerRING-type 2%3B atypical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370392+29299_319163.0428.0IntramembranePore-forming%3B Name%3DSegment H5
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370398+214299_319163.0933.0IntramembranePore-forming%3B Name%3DSegment H5
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000402622+214299_319163.0943.0IntramembranePore-forming%3B Name%3DSegment H5
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000403813+213299_319163.0924.0IntramembranePore-forming%3B Name%3DSegment H5
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000414165+212299_319163.0823.0IntramembranePore-forming%3B Name%3DSegment H5
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370392+29311_316163.0428.0MotifSelectivity filter
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370398+214311_316163.0933.0MotifSelectivity filter
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000402622+214311_316163.0943.0MotifSelectivity filter
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000403813+213311_316163.0924.0MotifSelectivity filter
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000414165+212311_316163.0823.0MotifSelectivity filter
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370392+29178_200163.0428.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370392+29222_229163.0428.0Topological domainExtracellular
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370392+29253_266163.0428.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370392+29288_298163.0428.0Topological domainExtracellular
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370392+29320_325163.0428.0Topological domainExtracellular
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370392+29347_932163.0428.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370398+214178_200163.0933.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370398+214222_229163.0933.0Topological domainExtracellular
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370398+214253_266163.0933.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370398+214288_298163.0933.0Topological domainExtracellular
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370398+214320_325163.0933.0Topological domainExtracellular
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370398+214347_932163.0933.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000402622+214178_200163.0943.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000402622+214222_229163.0943.0Topological domainExtracellular
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000402622+214253_266163.0943.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000402622+214288_298163.0943.0Topological domainExtracellular
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000402622+214320_325163.0943.0Topological domainExtracellular
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000402622+214347_932163.0943.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000403813+213178_200163.0924.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000403813+213222_229163.0924.0Topological domainExtracellular
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000403813+213253_266163.0924.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000403813+213288_298163.0924.0Topological domainExtracellular
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000403813+213320_325163.0924.0Topological domainExtracellular
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000403813+213347_932163.0924.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000414165+212178_200163.0823.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000414165+212222_229163.0823.0Topological domainExtracellular
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000414165+212253_266163.0823.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000414165+212288_298163.0823.0Topological domainExtracellular
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000414165+212320_325163.0823.0Topological domainExtracellular
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000414165+212347_932163.0823.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370392+29157_177163.0428.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370392+29201_221163.0428.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370392+29230_252163.0428.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370392+29267_287163.0428.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370392+29326_346163.0428.0TransmembraneHelical%3B Name%3DSegment S6
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370398+214157_177163.0933.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370398+214201_221163.0933.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370398+214230_252163.0933.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370398+214267_287163.0933.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000370398+214326_346163.0933.0TransmembraneHelical%3B Name%3DSegment S6
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000402622+214157_177163.0943.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000402622+214201_221163.0943.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000402622+214230_252163.0943.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000402622+214267_287163.0943.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000402622+214326_346163.0943.0TransmembraneHelical%3B Name%3DSegment S6
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000403813+213157_177163.0924.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000403813+213201_221163.0924.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000403813+213230_252163.0924.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000403813+213267_287163.0924.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000403813+213326_346163.0924.0TransmembraneHelical%3B Name%3DSegment S6
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000414165+212157_177163.0823.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000414165+212201_221163.0823.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000414165+212230_252163.0823.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000414165+212267_287163.0823.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNQ5chr6:73713721chr6:125397803ENST00000414165+212326_346163.0823.0TransmembraneHelical%3B Name%3DSegment S6


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KCNQ5
RNF217


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to KCNQ5-RNF217


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KCNQ5-RNF217


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource