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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:KDM2A-SYNDIG1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KDM2A-SYNDIG1
FusionPDB ID: 41738
FusionGDB2.0 ID: 41738
HgeneTgene
Gene symbol

KDM2A

SYNDIG1

Gene ID

22992

79953

Gene namelysine demethylase 2Asynapse differentiation inducing 1
SynonymsCXXC8|FBL11|FBL7|FBXL11|JHDM1A|LILINAC20orf39|DSPC2|IFITMD5|TMEM90B
Cytomap

11q13.2

20p11.21

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 2ACXXC-type zinc finger protein 8F-box and leucine-rich repeat protein 11F-box/LRR-repeat protein 11[Histone-H3]-lysine-36 demethylase 1AjmjC domain-containing histone demethylation protein 1Ajumonji C domain-containing hsynapse differentiation-inducing gene protein 1dispanin subfamily C member 2interferon induced transmembrane protein domain containing 5synapse differentiation induced gene 1transmembrane protein 90B
Modification date2020032020200313
UniProtAcc

Q9Y2K7

.
Ensembl transtripts involved in fusion geneENST idsENST00000526258, ENST00000398645, 
ENST00000529006, ENST00000308783, 
ENST00000530342, 		ENST00000376862, 
ENST00000482637, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score36 X 24 X 17=146884 X 5 X 3=60
# samples 505
** MAII scorelog2(50/14688*10)=-4.87656605875172
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: KDM2A [Title/Abstract] AND SYNDIG1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KDM2A(66999431)-SYNDIG1(24565492), # samples:2
Anticipated loss of major functional domain due to fusion event.KDM2A-SYNDIG1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM2A-SYNDIG1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM2A-SYNDIG1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM2A-SYNDIG1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSYNDIG1

GO:0051965

positive regulation of synapse assembly

20152115


check buttonFusion gene breakpoints across KDM2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SYNDIG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-6456-01AKDM2Achr11

66999431

+SYNDIG1chr20

24565492

+
ChimerDB4STADTCGA-BR-6456KDM2Achr11

66999431

+SYNDIG1chr20

24565491

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000398645KDM2Achr1166999431+ENST00000376862SYNDIG1chr2024565492+375223438642639591
ENST00000529006KDM2Achr1166999431+ENST00000376862SYNDIG1chr2024565492+333419254462221591
ENST00000398645KDM2Achr1166999431+ENST00000376862SYNDIG1chr2024565491+375223438642639591
ENST00000529006KDM2Achr1166999431+ENST00000376862SYNDIG1chr2024565491+333419254462221591

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398645ENST00000376862KDM2Achr1166999431+SYNDIG1chr2024565492+0.0029157080.9970843
ENST00000529006ENST00000376862KDM2Achr1166999431+SYNDIG1chr2024565492+0.0026512210.9973488
ENST00000398645ENST00000376862KDM2Achr1166999431+SYNDIG1chr2024565491+0.0029157080.9970843
ENST00000529006ENST00000376862KDM2Achr1166999431+SYNDIG1chr2024565491+0.0026512210.9973488

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>41738_41738_1_KDM2A-SYNDIG1_KDM2A_chr11_66999431_ENST00000398645_SYNDIG1_chr20_24565491_ENST00000376862_length(amino acids)=591AA_BP=493
MEPEEERIRYSQRLRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPD
PDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKES
QTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIEL
KQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLS
MDLELNGLESGNGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQ
VHLTHFELEGLRCLVDKLESLPLHKKCVPTGIEDEDALIADVKSDYSSDTESEDNFLMMPPRDHLGLSVFSMLCCFWPLGIAAFYLSHET

--------------------------------------------------------------

>41738_41738_2_KDM2A-SYNDIG1_KDM2A_chr11_66999431_ENST00000398645_SYNDIG1_chr20_24565492_ENST00000376862_length(amino acids)=591AA_BP=493
MEPEEERIRYSQRLRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPD
PDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKES
QTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIEL
KQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLS
MDLELNGLESGNGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQ
VHLTHFELEGLRCLVDKLESLPLHKKCVPTGIEDEDALIADVKSDYSSDTESEDNFLMMPPRDHLGLSVFSMLCCFWPLGIAAFYLSHET

--------------------------------------------------------------

>41738_41738_3_KDM2A-SYNDIG1_KDM2A_chr11_66999431_ENST00000529006_SYNDIG1_chr20_24565491_ENST00000376862_length(amino acids)=591AA_BP=493
MEPEEERIRYSQRLRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPD
PDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKES
QTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIEL
KQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLS
MDLELNGLESGNGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQ
VHLTHFELEGLRCLVDKLESLPLHKKCVPTGIEDEDALIADVKSDYSSDTESEDNFLMMPPRDHLGLSVFSMLCCFWPLGIAAFYLSHET

--------------------------------------------------------------

>41738_41738_4_KDM2A-SYNDIG1_KDM2A_chr11_66999431_ENST00000529006_SYNDIG1_chr20_24565492_ENST00000376862_length(amino acids)=591AA_BP=493
MEPEEERIRYSQRLRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPD
PDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKES
QTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIEL
KQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLS
MDLELNGLESGNGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQ
VHLTHFELEGLRCLVDKLESLPLHKKCVPTGIEDEDALIADVKSDYSSDTESEDNFLMMPPRDHLGLSVFSMLCCFWPLGIAAFYLSHET

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:66999431/chr20:24565492)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM2A

Q9Y2K7

.
FUNCTION: Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-ARNTL/BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:26037310, ECO:0000269|PubMed:28262558}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM2Achr11:66999431chr20:24565491ENST00000398645+1221148_316493.01490.3333333333333DomainJmjC
HgeneKDM2Achr11:66999431chr20:24565491ENST00000529006+1221148_316493.01163.0DomainJmjC
HgeneKDM2Achr11:66999431chr20:24565492ENST00000398645+1221148_316493.01490.3333333333333DomainJmjC
HgeneKDM2Achr11:66999431chr20:24565492ENST00000529006+1221148_316493.01163.0DomainJmjC
TgeneSYNDIG1chr11:66999431chr20:24565491ENST0000037686214229_249160.0259.0IntramembraneHelical
TgeneSYNDIG1chr11:66999431chr20:24565492ENST0000037686214229_249160.0259.0IntramembraneHelical
TgeneSYNDIG1chr11:66999431chr20:24565491ENST0000037686214203_228160.0259.0Topological domainExtracellular
TgeneSYNDIG1chr11:66999431chr20:24565491ENST0000037686214250_258160.0259.0Topological domainExtracellular
TgeneSYNDIG1chr11:66999431chr20:24565492ENST0000037686214203_228160.0259.0Topological domainExtracellular
TgeneSYNDIG1chr11:66999431chr20:24565492ENST0000037686214250_258160.0259.0Topological domainExtracellular
TgeneSYNDIG1chr11:66999431chr20:24565491ENST0000037686214182_202160.0259.0TransmembraneHelical
TgeneSYNDIG1chr11:66999431chr20:24565492ENST0000037686214182_202160.0259.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM2Achr11:66999431chr20:24565491ENST00000308783+110148_3160621.0DomainJmjC
HgeneKDM2Achr11:66999431chr20:24565491ENST00000308783+110889_9360621.0DomainNote=F-box
HgeneKDM2Achr11:66999431chr20:24565491ENST00000398645+1221889_936493.01490.3333333333333DomainNote=F-box
HgeneKDM2Achr11:66999431chr20:24565491ENST00000529006+1221889_936493.01163.0DomainNote=F-box
HgeneKDM2Achr11:66999431chr20:24565491ENST00000530342+110148_3160724.0DomainJmjC
HgeneKDM2Achr11:66999431chr20:24565491ENST00000530342+110889_9360724.0DomainNote=F-box
HgeneKDM2Achr11:66999431chr20:24565492ENST00000308783+110148_3160621.0DomainJmjC
HgeneKDM2Achr11:66999431chr20:24565492ENST00000308783+110889_9360621.0DomainNote=F-box
HgeneKDM2Achr11:66999431chr20:24565492ENST00000398645+1221889_936493.01490.3333333333333DomainNote=F-box
HgeneKDM2Achr11:66999431chr20:24565492ENST00000529006+1221889_936493.01163.0DomainNote=F-box
HgeneKDM2Achr11:66999431chr20:24565492ENST00000530342+110148_3160724.0DomainJmjC
HgeneKDM2Achr11:66999431chr20:24565492ENST00000530342+110889_9360724.0DomainNote=F-box
HgeneKDM2Achr11:66999431chr20:24565491ENST00000308783+1101048_10730621.0RepeatNote=LRR 3
HgeneKDM2Achr11:66999431chr20:24565491ENST00000308783+1101074_11030621.0RepeatNote=LRR 4
HgeneKDM2Achr11:66999431chr20:24565491ENST00000308783+1101104_11280621.0RepeatNote=LRR 5
HgeneKDM2Achr11:66999431chr20:24565491ENST00000308783+1101129_11560621.0RepeatNote=LRR 6
HgeneKDM2Achr11:66999431chr20:24565491ENST00000308783+110961_9820621.0RepeatNote=LRR 1
HgeneKDM2Achr11:66999431chr20:24565491ENST00000308783+110984_10100621.0RepeatNote=LRR 2
HgeneKDM2Achr11:66999431chr20:24565491ENST00000398645+12211048_1073493.01490.3333333333333RepeatNote=LRR 3
HgeneKDM2Achr11:66999431chr20:24565491ENST00000398645+12211074_1103493.01490.3333333333333RepeatNote=LRR 4
HgeneKDM2Achr11:66999431chr20:24565491ENST00000398645+12211104_1128493.01490.3333333333333RepeatNote=LRR 5
HgeneKDM2Achr11:66999431chr20:24565491ENST00000398645+12211129_1156493.01490.3333333333333RepeatNote=LRR 6
HgeneKDM2Achr11:66999431chr20:24565491ENST00000398645+1221961_982493.01490.3333333333333RepeatNote=LRR 1
HgeneKDM2Achr11:66999431chr20:24565491ENST00000398645+1221984_1010493.01490.3333333333333RepeatNote=LRR 2
HgeneKDM2Achr11:66999431chr20:24565491ENST00000529006+12211048_1073493.01163.0RepeatNote=LRR 3
HgeneKDM2Achr11:66999431chr20:24565491ENST00000529006+12211074_1103493.01163.0RepeatNote=LRR 4
HgeneKDM2Achr11:66999431chr20:24565491ENST00000529006+12211104_1128493.01163.0RepeatNote=LRR 5
HgeneKDM2Achr11:66999431chr20:24565491ENST00000529006+12211129_1156493.01163.0RepeatNote=LRR 6
HgeneKDM2Achr11:66999431chr20:24565491ENST00000529006+1221961_982493.01163.0RepeatNote=LRR 1
HgeneKDM2Achr11:66999431chr20:24565491ENST00000529006+1221984_1010493.01163.0RepeatNote=LRR 2
HgeneKDM2Achr11:66999431chr20:24565491ENST00000530342+1101048_10730724.0RepeatNote=LRR 3
HgeneKDM2Achr11:66999431chr20:24565491ENST00000530342+1101074_11030724.0RepeatNote=LRR 4
HgeneKDM2Achr11:66999431chr20:24565491ENST00000530342+1101104_11280724.0RepeatNote=LRR 5
HgeneKDM2Achr11:66999431chr20:24565491ENST00000530342+1101129_11560724.0RepeatNote=LRR 6
HgeneKDM2Achr11:66999431chr20:24565491ENST00000530342+110961_9820724.0RepeatNote=LRR 1
HgeneKDM2Achr11:66999431chr20:24565491ENST00000530342+110984_10100724.0RepeatNote=LRR 2
HgeneKDM2Achr11:66999431chr20:24565492ENST00000308783+1101048_10730621.0RepeatNote=LRR 3
HgeneKDM2Achr11:66999431chr20:24565492ENST00000308783+1101074_11030621.0RepeatNote=LRR 4
HgeneKDM2Achr11:66999431chr20:24565492ENST00000308783+1101104_11280621.0RepeatNote=LRR 5
HgeneKDM2Achr11:66999431chr20:24565492ENST00000308783+1101129_11560621.0RepeatNote=LRR 6
HgeneKDM2Achr11:66999431chr20:24565492ENST00000308783+110961_9820621.0RepeatNote=LRR 1
HgeneKDM2Achr11:66999431chr20:24565492ENST00000308783+110984_10100621.0RepeatNote=LRR 2
HgeneKDM2Achr11:66999431chr20:24565492ENST00000398645+12211048_1073493.01490.3333333333333RepeatNote=LRR 3
HgeneKDM2Achr11:66999431chr20:24565492ENST00000398645+12211074_1103493.01490.3333333333333RepeatNote=LRR 4
HgeneKDM2Achr11:66999431chr20:24565492ENST00000398645+12211104_1128493.01490.3333333333333RepeatNote=LRR 5
HgeneKDM2Achr11:66999431chr20:24565492ENST00000398645+12211129_1156493.01490.3333333333333RepeatNote=LRR 6
HgeneKDM2Achr11:66999431chr20:24565492ENST00000398645+1221961_982493.01490.3333333333333RepeatNote=LRR 1
HgeneKDM2Achr11:66999431chr20:24565492ENST00000398645+1221984_1010493.01490.3333333333333RepeatNote=LRR 2
HgeneKDM2Achr11:66999431chr20:24565492ENST00000529006+12211048_1073493.01163.0RepeatNote=LRR 3
HgeneKDM2Achr11:66999431chr20:24565492ENST00000529006+12211074_1103493.01163.0RepeatNote=LRR 4
HgeneKDM2Achr11:66999431chr20:24565492ENST00000529006+12211104_1128493.01163.0RepeatNote=LRR 5
HgeneKDM2Achr11:66999431chr20:24565492ENST00000529006+12211129_1156493.01163.0RepeatNote=LRR 6
HgeneKDM2Achr11:66999431chr20:24565492ENST00000529006+1221961_982493.01163.0RepeatNote=LRR 1
HgeneKDM2Achr11:66999431chr20:24565492ENST00000529006+1221984_1010493.01163.0RepeatNote=LRR 2
HgeneKDM2Achr11:66999431chr20:24565492ENST00000530342+1101048_10730724.0RepeatNote=LRR 3
HgeneKDM2Achr11:66999431chr20:24565492ENST00000530342+1101074_11030724.0RepeatNote=LRR 4
HgeneKDM2Achr11:66999431chr20:24565492ENST00000530342+1101104_11280724.0RepeatNote=LRR 5
HgeneKDM2Achr11:66999431chr20:24565492ENST00000530342+1101129_11560724.0RepeatNote=LRR 6
HgeneKDM2Achr11:66999431chr20:24565492ENST00000530342+110961_9820724.0RepeatNote=LRR 1
HgeneKDM2Achr11:66999431chr20:24565492ENST00000530342+110984_10100724.0RepeatNote=LRR 2
HgeneKDM2Achr11:66999431chr20:24565491ENST00000308783+110564_6100621.0Zinc fingerCXXC-type
HgeneKDM2Achr11:66999431chr20:24565491ENST00000308783+110617_6780621.0Zinc fingerPHD-type
HgeneKDM2Achr11:66999431chr20:24565491ENST00000398645+1221564_610493.01490.3333333333333Zinc fingerCXXC-type
HgeneKDM2Achr11:66999431chr20:24565491ENST00000398645+1221617_678493.01490.3333333333333Zinc fingerPHD-type
HgeneKDM2Achr11:66999431chr20:24565491ENST00000529006+1221564_610493.01163.0Zinc fingerCXXC-type
HgeneKDM2Achr11:66999431chr20:24565491ENST00000529006+1221617_678493.01163.0Zinc fingerPHD-type
HgeneKDM2Achr11:66999431chr20:24565491ENST00000530342+110564_6100724.0Zinc fingerCXXC-type
HgeneKDM2Achr11:66999431chr20:24565491ENST00000530342+110617_6780724.0Zinc fingerPHD-type
HgeneKDM2Achr11:66999431chr20:24565492ENST00000308783+110564_6100621.0Zinc fingerCXXC-type
HgeneKDM2Achr11:66999431chr20:24565492ENST00000308783+110617_6780621.0Zinc fingerPHD-type
HgeneKDM2Achr11:66999431chr20:24565492ENST00000398645+1221564_610493.01490.3333333333333Zinc fingerCXXC-type
HgeneKDM2Achr11:66999431chr20:24565492ENST00000398645+1221617_678493.01490.3333333333333Zinc fingerPHD-type
HgeneKDM2Achr11:66999431chr20:24565492ENST00000529006+1221564_610493.01163.0Zinc fingerCXXC-type
HgeneKDM2Achr11:66999431chr20:24565492ENST00000529006+1221617_678493.01163.0Zinc fingerPHD-type
HgeneKDM2Achr11:66999431chr20:24565492ENST00000530342+110564_6100724.0Zinc fingerCXXC-type
HgeneKDM2Achr11:66999431chr20:24565492ENST00000530342+110617_6780724.0Zinc fingerPHD-type
TgeneSYNDIG1chr11:66999431chr20:24565491ENST0000037686214151_155160.0259.0Compositional biasNote=Poly-Glu
TgeneSYNDIG1chr11:66999431chr20:24565492ENST0000037686214151_155160.0259.0Compositional biasNote=Poly-Glu
TgeneSYNDIG1chr11:66999431chr20:24565491ENST00000376862141_181160.0259.0Topological domainCytoplasmic
TgeneSYNDIG1chr11:66999431chr20:24565492ENST00000376862141_181160.0259.0Topological domainCytoplasmic


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KDM2A
SYNDIG1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to KDM2A-SYNDIG1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KDM2A-SYNDIG1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource