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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:KDM2B-RHOF

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KDM2B-RHOF
FusionPDB ID: 41752
FusionGDB2.0 ID: 41752
HgeneTgene
Gene symbol

KDM2B

RHOF

Gene ID

84678

54509

Gene namelysine demethylase 2Bras homolog family member F, filopodia associated
SynonymsCXXC2|FBXL10|Fbl10|JHDM1B|PCCX2ARHF|RIF
Cytomap

12q24.31

12q24.31

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 2BCXXC-type zinc finger protein 2F-box and leucine-rich repeat protein 10F-box protein FBL10F-box/LRR-repeat protein 10JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) protein[Histone-H3]-lysine-36 demethyrho-related GTP-binding protein RhoFras homolog family member F (in filopodia)ras homolog gene family, member F (in filopodia)rho family GTPase Rifrho in filopodia
Modification date2020031320200313
UniProtAcc

Q8NHM5

.
Ensembl transtripts involved in fusion geneENST idsENST00000377069, ENST00000377071, 
ENST00000536437, ENST00000542973, 
ENST00000538046, ENST00000543852, 
ENST00000537171, ENST00000537265, 
ENST00000545544, ENST00000267205, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 11 X 9=12871 X 2 X 2=4
# samples 152
** MAII scorelog2(15/1287*10)=-3.10097764772482
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: KDM2B [Title/Abstract] AND RHOF [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KDM2B(121932382)-RHOF(122231145), # samples:3
Anticipated loss of major functional domain due to fusion event.KDM2B-RHOF seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM2B-RHOF seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM2B-RHOF seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM2B-RHOF seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM2B-RHOF seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KDM2B-RHOF seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KDM2B-RHOF seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KDM2B-RHOF seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKDM2B

GO:0035518

histone H2A monoubiquitination

16943429

HgeneKDM2B

GO:0070544

histone H3-K36 demethylation

26237645

TgeneRHOF

GO:0007015

actin filament organization

11084341


check buttonFusion gene breakpoints across KDM2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RHOF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-A4MH-01AKDM2Bchr12

121932382

-RHOFchr12

122217568

-
ChimerDB4UCECTCGA-A5-A7WK-01AKDM2Bchr12

121932382

-RHOFchr12

122231145

-
ChimerDB4UCECTCGA-A5-A7WKKDM2Bchr12

121932382

-RHOFchr12

122231145

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000377069KDM2Bchr12121932382-ENST00000267205RHOFchr12122231145-428620483862545719
ENST00000377071KDM2Bchr12121932382-ENST00000267205RHOFchr12122231145-40451807732304743
ENST00000377069KDM2Bchr12121932382-ENST00000537265RHOFchr12122217568-229320483862212608
ENST00000377071KDM2Bchr12121932382-ENST00000537265RHOFchr12122217568-20521807731971632
ENST00000536437KDM2Bchr12121932382-ENST00000267205RHOFchr12122217568-360316983151862515

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377069ENST00000267205KDM2Bchr12121932382-RHOFchr12122231145-0.0021443760.9978556
ENST00000377071ENST00000267205KDM2Bchr12121932382-RHOFchr12122231145-0.0020042590.99799573
ENST00000377069ENST00000537265KDM2Bchr12121932382-RHOFchr12122217568-0.002661690.99733835
ENST00000377071ENST00000537265KDM2Bchr12121932382-RHOFchr12122217568-0.0027188050.9972812
ENST00000536437ENST00000267205KDM2Bchr12121932382-RHOFchr12122217568-0.0021572460.9978428

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>41752_41752_1_KDM2B-RHOF_KDM2B_chr12_121932382_ENST00000377069_RHOF_chr12_122217568_ENST00000537265_length(amino acids)=608AA_BP=554
MVNSPKKMEAEKDSGRRLRPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGKDFNYEYVQREALRVPLIFREKDGL
GIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWP
QHLKEKQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVER
CQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEY
QRESMLIDAPRKPSIDGFSSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTPSEDQEALGKKPKAPALRFLKRTLS
NESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAI

--------------------------------------------------------------

>41752_41752_2_KDM2B-RHOF_KDM2B_chr12_121932382_ENST00000377069_RHOF_chr12_122231145_ENST00000267205_length(amino acids)=719AA_BP=552
MVNSPKKMEAEKDSGRRLRPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGKDFNYEYVQREALRVPLIFREKDGL
GIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWP
QHLKEKQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVER
CQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEY
QRESMLIDAPRKPSIDGFSSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTPSEDQEALGKKPKAPALRFLKRTLS
NESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAI
TGVPVVTWPKKTPKHYAPSVFEKYTASVTVGSKEVTLNLYDTAGQEDYDRLRPLSYQNTHLVLICYDVMNPTSYDNVLIKWFPEVTHFCR

--------------------------------------------------------------

>41752_41752_3_KDM2B-RHOF_KDM2B_chr12_121932382_ENST00000377071_RHOF_chr12_122217568_ENST00000537265_length(amino acids)=632AA_BP=578
MAGPQMGGSAEDHPPRKRHAAEKQKKKTVIYTKCFEFESATQRPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGK
DFNYEYVQREALRVPLIFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSH
TKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHN
LALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYY
EMCWYVLERYVYCVTQRSHLTQEYQRESMLIDAPRKPSIDGFSSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTP
SEDQEALGKKPKAPALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIED
PQALLEGVKNVLKEHADDDPSLAITGVPVVTWPKKTPKGLSACEQIRAALYLECSAKFRENVEDVFREAAKVALSALKKAQRQKKRRLCL

--------------------------------------------------------------

>41752_41752_4_KDM2B-RHOF_KDM2B_chr12_121932382_ENST00000377071_RHOF_chr12_122231145_ENST00000267205_length(amino acids)=743AA_BP=576
MAGPQMGGSAEDHPPRKRHAAEKQKKKTVIYTKCFEFESATQRPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGK
DFNYEYVQREALRVPLIFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSH
TKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHN
LALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYY
EMCWYVLERYVYCVTQRSHLTQEYQRESMLIDAPRKPSIDGFSSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTP
SEDQEALGKKPKAPALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIED
PQALLEGVKNVLKEHADDDPSLAITGVPVVTWPKKTPKHYAPSVFEKYTASVTVGSKEVTLNLYDTAGQEDYDRLRPLSYQNTHLVLICY
DVMNPTSYDNVLIKWFPEVTHFCRGIPMVLIGCKTDLRKDKEQLRKLRAAQLEPITYMQGLSACEQIRAALYLECSAKFRENVEDVFREA

--------------------------------------------------------------

>41752_41752_5_KDM2B-RHOF_KDM2B_chr12_121932382_ENST00000536437_RHOF_chr12_122217568_ENST00000267205_length(amino acids)=515AA_BP=461
MPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHL
KEKQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVERCQR
IELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEYQRE
SMLIDAPRKPSIDGFSSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTPSEDQEALGKKPKAPALRFLKRTLSNES
EESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAITGV

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:121932382/chr12:122231145)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM2B

Q8NHM5

.
FUNCTION: Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:17994099, ECO:0000269|PubMed:26237645, ECO:0000305}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000377069-1223409_430547.01266.0Compositional biasNote=Glu-rich
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000377071-1223409_430578.01337.0Compositional biasNote=Glu-rich
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377069-1223409_430547.01266.0Compositional biasNote=Glu-rich
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377071-1223409_430578.01337.0Compositional biasNote=Glu-rich
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000377069-1223178_346547.01266.0DomainJmjC
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000377071-1223178_346578.01337.0DomainJmjC
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377069-1223178_346547.01266.0DomainJmjC
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377071-1223178_346578.01337.0DomainJmjC
TgeneRHOFchr12:121932382chr12:122231145ENST000002672050548_5646.0212.0MotifEffector region
TgeneRHOFchr12:121932382chr12:122231145ENST0000026720505131_13446.0212.0Nucleotide bindingGTP
TgeneRHOFchr12:121932382chr12:122231145ENST000002672050573_7746.0212.0Nucleotide bindingGTP

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000377069-1223943_971547.01266.0Coiled coilOntology_term=ECO:0000255
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000377071-1223943_971578.01337.0Coiled coilOntology_term=ECO:0000255
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000542973-214943_9710912.0Coiled coilOntology_term=ECO:0000255
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377069-1223943_971547.01266.0Coiled coilOntology_term=ECO:0000255
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377071-1223943_971578.01337.0Coiled coilOntology_term=ECO:0000255
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000542973-214943_9710912.0Coiled coilOntology_term=ECO:0000255
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000377069-12231014_1056547.01266.0Compositional biasNote=Pro-rich
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000377071-12231014_1056578.01337.0Compositional biasNote=Pro-rich
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000542973-2141014_10560912.0Compositional biasNote=Pro-rich
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000542973-214409_4300912.0Compositional biasNote=Glu-rich
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377069-12231014_1056547.01266.0Compositional biasNote=Pro-rich
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377071-12231014_1056578.01337.0Compositional biasNote=Pro-rich
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000542973-2141014_10560912.0Compositional biasNote=Pro-rich
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000542973-214409_4300912.0Compositional biasNote=Glu-rich
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000377069-12231059_1105547.01266.0DomainNote=F-box
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000377071-12231059_1105578.01337.0DomainNote=F-box
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000542973-2141059_11050912.0DomainNote=F-box
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000542973-214178_3460912.0DomainJmjC
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377069-12231059_1105547.01266.0DomainNote=F-box
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377071-12231059_1105578.01337.0DomainNote=F-box
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000542973-2141059_11050912.0DomainNote=F-box
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000542973-214178_3460912.0DomainJmjC
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000377069-12231093_1120547.01266.0RepeatNote=LRR 1
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000377069-12231133_1154547.01266.0RepeatNote=LRR 2
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000377069-12231156_1182547.01266.0RepeatNote=LRR 3
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000377069-12231222_1247547.01266.0RepeatNote=LRR 4
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000377069-12231248_1277547.01266.0RepeatNote=LRR 5
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000377069-12231278_1302547.01266.0RepeatNote=LRR 6
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000377069-12231303_1336547.01266.0RepeatNote=LRR 7
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000377071-12231093_1120578.01337.0RepeatNote=LRR 1
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000377071-12231133_1154578.01337.0RepeatNote=LRR 2
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000377071-12231156_1182578.01337.0RepeatNote=LRR 3
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000377071-12231222_1247578.01337.0RepeatNote=LRR 4
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000377071-12231248_1277578.01337.0RepeatNote=LRR 5
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000377071-12231278_1302578.01337.0RepeatNote=LRR 6
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000377071-12231303_1336578.01337.0RepeatNote=LRR 7
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000542973-2141093_11200912.0RepeatNote=LRR 1
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000542973-2141133_11540912.0RepeatNote=LRR 2
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000542973-2141156_11820912.0RepeatNote=LRR 3
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000542973-2141222_12470912.0RepeatNote=LRR 4
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000542973-2141248_12770912.0RepeatNote=LRR 5
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000542973-2141278_13020912.0RepeatNote=LRR 6
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000542973-2141303_13360912.0RepeatNote=LRR 7
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377069-12231093_1120547.01266.0RepeatNote=LRR 1
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377069-12231133_1154547.01266.0RepeatNote=LRR 2
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377069-12231156_1182547.01266.0RepeatNote=LRR 3
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377069-12231222_1247547.01266.0RepeatNote=LRR 4
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377069-12231248_1277547.01266.0RepeatNote=LRR 5
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377069-12231278_1302547.01266.0RepeatNote=LRR 6
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377069-12231303_1336547.01266.0RepeatNote=LRR 7
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377071-12231093_1120578.01337.0RepeatNote=LRR 1
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377071-12231133_1154578.01337.0RepeatNote=LRR 2
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377071-12231156_1182578.01337.0RepeatNote=LRR 3
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377071-12231222_1247578.01337.0RepeatNote=LRR 4
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377071-12231248_1277578.01337.0RepeatNote=LRR 5
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377071-12231278_1302578.01337.0RepeatNote=LRR 6
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377071-12231303_1336578.01337.0RepeatNote=LRR 7
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000542973-2141093_11200912.0RepeatNote=LRR 1
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000542973-2141133_11540912.0RepeatNote=LRR 2
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000542973-2141156_11820912.0RepeatNote=LRR 3
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000542973-2141222_12470912.0RepeatNote=LRR 4
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000542973-2141248_12770912.0RepeatNote=LRR 5
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000542973-2141278_13020912.0RepeatNote=LRR 6
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000542973-2141303_13360912.0RepeatNote=LRR 7
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000377069-1223606_652547.01266.0Zinc fingerCXXC-type
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000377069-1223659_725547.01266.0Zinc fingerPHD-type
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000377071-1223606_652578.01337.0Zinc fingerCXXC-type
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000377071-1223659_725578.01337.0Zinc fingerPHD-type
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000542973-214606_6520912.0Zinc fingerCXXC-type
HgeneKDM2Bchr12:121932382chr12:122217568ENST00000542973-214659_7250912.0Zinc fingerPHD-type
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377069-1223606_652547.01266.0Zinc fingerCXXC-type
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377069-1223659_725547.01266.0Zinc fingerPHD-type
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377071-1223606_652578.01337.0Zinc fingerCXXC-type
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377071-1223659_725578.01337.0Zinc fingerPHD-type
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000542973-214606_6520912.0Zinc fingerCXXC-type
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000542973-214659_7250912.0Zinc fingerPHD-type
TgeneRHOFchr12:121932382chr12:122217568ENST000002672053548_56157.0212.0MotifEffector region
TgeneRHOFchr12:121932382chr12:122217568ENST0000026720535131_134157.0212.0Nucleotide bindingGTP
TgeneRHOFchr12:121932382chr12:122217568ENST000002672053526_33157.0212.0Nucleotide bindingGTP
TgeneRHOFchr12:121932382chr12:122217568ENST000002672053573_77157.0212.0Nucleotide bindingGTP
TgeneRHOFchr12:121932382chr12:122231145ENST000002672050526_3346.0212.0Nucleotide bindingGTP


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1500_KDM2B_121932382_RHOF_122231145_ranked_0.pdbKDM2B121932382121932382ENST00000267205RHOFchr12122231145-
MAGPQMGGSAEDHPPRKRHAAEKQKKKTVIYTKCFEFESATQRPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGK
DFNYEYVQREALRVPLIFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSH
TKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHN
LALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYY
EMCWYVLERYVYCVTQRSHLTQEYQRESMLIDAPRKPSIDGFSSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTP
SEDQEALGKKPKAPALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIED
PQALLEGVKNVLKEHADDDPSLAITGVPVVTWPKKTPKHYAPSVFEKYTASVTVGSKEVTLNLYDTAGQEDYDRLRPLSYQNTHLVLICY
DVMNPTSYDNVLIKWFPEVTHFCRGIPMVLIGCKTDLRKDKEQLRKLRAAQLEPITYMQGLSACEQIRAALYLECSAKFRENVEDVFREA
743


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
KDM2B_pLDDT.png
all structure
all structure
RHOF_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KDM2B
RHOF


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to KDM2B-RHOF


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KDM2B-RHOF


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource