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Fusion Protein:KDM3A-CRIM1 |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: KDM3A-CRIM1 | FusionPDB ID: 41759 | FusionGDB2.0 ID: 41759 | Hgene | Tgene | Gene symbol | KDM3A | CRIM1 | Gene ID | 55818 | 51232 |
Gene name | lysine demethylase 3A | cysteine rich transmembrane BMP regulator 1 | |
Synonyms | JHDM2A|JHMD2A|JMJD1|JMJD1A|TSGA | CRIM-1|S52 | |
Cytomap | 2p11.2 | 2p22.2 | |
Type of gene | protein-coding | protein-coding | |
Description | lysine-specific demethylase 3AjmjC domain-containing histone demethylation protein 2Ajumonji C domain-containing histone demethylase 2Ajumonji domain-containing protein 1Alysine (K)-specific demethylase 3Atestis-specific protein A | cysteine-rich motor neuron 1 proteincysteine rich transmembrane BMP regulator 1 (chordin-like)cysteine-rich repeat-containing protein S52 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q9Y4C1 | Q9NZV1 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000312912, ENST00000409064, ENST00000409556, ENST00000542128, ENST00000485171, | ENST00000473403, ENST00000280527, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 13 X 12 X 7=1092 | 8 X 10 X 4=320 |
# samples | 15 | 10 | |
** MAII score | log2(15/1092*10)=-2.86393845042397 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/320*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: KDM3A [Title/Abstract] AND CRIM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | KDM3A(86691339)-CRIM1(36691677), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | KDM3A-CRIM1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KDM3A-CRIM1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KDM3A-CRIM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KDM3A-CRIM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | KDM3A | GO:0009755 | hormone-mediated signaling pathway | 16603237 |
Hgene | KDM3A | GO:0030521 | androgen receptor signaling pathway | 16603237 |
Hgene | KDM3A | GO:0033169 | histone H3-K9 demethylation | 16603237 |
Hgene | KDM3A | GO:0046293 | formaldehyde biosynthetic process | 16603237 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | KIRP | TCGA-G7-6792-01A | KDM3A | chr2 | 86691339 | - | CRIM1 | chr2 | 36691677 | + |
ChimerDB4 | KIRP | TCGA-G7-6792-01A | KDM3A | chr2 | 86691339 | + | CRIM1 | chr2 | 36691677 | + |
ChimerDB4 | KIRP | TCGA-G7-6792 | KDM3A | chr2 | 86691339 | + | CRIM1 | chr2 | 36691676 | + |
ChimerDB4 | KIRP | TCGA-G7-6792 | KDM3A | chr2 | 86691339 | + | CRIM1 | chr2 | 36691677 | + |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000409556 | KDM3A | chr2 | 86691339 | + | ENST00000280527 | CRIM1 | chr2 | 36691677 | + | 6048 | 1372 | 365 | 3613 | 1082 |
ENST00000312912 | KDM3A | chr2 | 86691339 | + | ENST00000280527 | CRIM1 | chr2 | 36691677 | + | 6010 | 1334 | 327 | 3575 | 1082 |
ENST00000409064 | KDM3A | chr2 | 86691339 | + | ENST00000280527 | CRIM1 | chr2 | 36691677 | + | 5741 | 1065 | 58 | 3306 | 1082 |
ENST00000542128 | KDM3A | chr2 | 86691339 | + | ENST00000280527 | CRIM1 | chr2 | 36691677 | + | 5527 | 851 | 0 | 3092 | 1030 |
ENST00000409556 | KDM3A | chr2 | 86691339 | + | ENST00000280527 | CRIM1 | chr2 | 36691676 | + | 6048 | 1372 | 365 | 3613 | 1082 |
ENST00000312912 | KDM3A | chr2 | 86691339 | + | ENST00000280527 | CRIM1 | chr2 | 36691676 | + | 6010 | 1334 | 327 | 3575 | 1082 |
ENST00000409064 | KDM3A | chr2 | 86691339 | + | ENST00000280527 | CRIM1 | chr2 | 36691676 | + | 5741 | 1065 | 58 | 3306 | 1082 |
ENST00000542128 | KDM3A | chr2 | 86691339 | + | ENST00000280527 | CRIM1 | chr2 | 36691676 | + | 5527 | 851 | 0 | 3092 | 1030 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000409556 | ENST00000280527 | KDM3A | chr2 | 86691339 | + | CRIM1 | chr2 | 36691677 | + | 0.00013963 | 0.9998604 |
ENST00000312912 | ENST00000280527 | KDM3A | chr2 | 86691339 | + | CRIM1 | chr2 | 36691677 | + | 0.00012447 | 0.99987555 |
ENST00000409064 | ENST00000280527 | KDM3A | chr2 | 86691339 | + | CRIM1 | chr2 | 36691677 | + | 9.06E-05 | 0.9999094 |
ENST00000542128 | ENST00000280527 | KDM3A | chr2 | 86691339 | + | CRIM1 | chr2 | 36691677 | + | 7.96E-05 | 0.99992037 |
ENST00000409556 | ENST00000280527 | KDM3A | chr2 | 86691339 | + | CRIM1 | chr2 | 36691676 | + | 0.00013963 | 0.9998604 |
ENST00000312912 | ENST00000280527 | KDM3A | chr2 | 86691339 | + | CRIM1 | chr2 | 36691676 | + | 0.00012447 | 0.99987555 |
ENST00000409064 | ENST00000280527 | KDM3A | chr2 | 86691339 | + | CRIM1 | chr2 | 36691676 | + | 9.06E-05 | 0.9999094 |
ENST00000542128 | ENST00000280527 | KDM3A | chr2 | 86691339 | + | CRIM1 | chr2 | 36691676 | + | 7.96E-05 | 0.99992037 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >41759_41759_1_KDM3A-CRIM1_KDM3A_chr2_86691339_ENST00000312912_CRIM1_chr2_36691676_ENST00000280527_length(amino acids)=1082AA_BP=336 MVLTLGESWPVLVGRRFLSLSAADGSDGSHDSWDVERVAEWPWLSGTIRAVSHTDVTKKDLKVCVEFDGESWRKRRWIEVYSLLRRAFLV EHNLVLAERKSPEISERIVQWPAITYKPLLDKAGLGSITSVRFLGDQQRVFLSKDLLKPIQDVNSLRLSLTDNQIVSKEFQALIVKHLDE SHLLKGDKNLVGSEVKIYSLDPSTQWFSATVINGNPASKTLQVNCEEIPALKIVDPSLIHVEVVHDNLVTCGNSARIGAVKRKSSENNGT LVSKQAKSCSEASPSMCPVQSVPTTVFKEILLGCTAATPPSKDPRQQSTPQAANSPPNLGAKIPQGCECLSGLCGFPVCEVGSTPRIVSR GDGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINCERYYVPEGECCPVCEDPVYPFNNPAGCY ANGLILAHGDRWREDDCTFCQCVNGERHCVATVCGQTCTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDHNGCR TCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIICDKYCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDS HGCLICKCREASASAGPPILSGTCLTVDGHHHKNEESWHDGCRECYCLNGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELS TPSICHAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQDSCCPQCTDQPFRPSLSRNNSVPNYCKNDEGDIFLAA ESWKPDVCTSCICIDSVISCFSESCPSVSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKAYADEERWDLDSCTHCYCLQGQTLCSTVSC PPLPCVEPINVEGSCCPMCPEMYVPEPTNIPIEKTNHRGEVDLEVPLWPTPSENDIVHLPRDMGHLQVDYRDNRLHPSEDSSLDSIASVV VPIIICLSIIIAFLFINQKKQWIPLLCWYRTPTKPSSLNNQLVSVDCKKGTRVQVDSSQRMLRIAEPDARFSGFYSMQKQNHLQADNFYQ -------------------------------------------------------------- >41759_41759_2_KDM3A-CRIM1_KDM3A_chr2_86691339_ENST00000312912_CRIM1_chr2_36691677_ENST00000280527_length(amino acids)=1082AA_BP=336 MVLTLGESWPVLVGRRFLSLSAADGSDGSHDSWDVERVAEWPWLSGTIRAVSHTDVTKKDLKVCVEFDGESWRKRRWIEVYSLLRRAFLV EHNLVLAERKSPEISERIVQWPAITYKPLLDKAGLGSITSVRFLGDQQRVFLSKDLLKPIQDVNSLRLSLTDNQIVSKEFQALIVKHLDE SHLLKGDKNLVGSEVKIYSLDPSTQWFSATVINGNPASKTLQVNCEEIPALKIVDPSLIHVEVVHDNLVTCGNSARIGAVKRKSSENNGT LVSKQAKSCSEASPSMCPVQSVPTTVFKEILLGCTAATPPSKDPRQQSTPQAANSPPNLGAKIPQGCECLSGLCGFPVCEVGSTPRIVSR GDGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINCERYYVPEGECCPVCEDPVYPFNNPAGCY ANGLILAHGDRWREDDCTFCQCVNGERHCVATVCGQTCTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDHNGCR TCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIICDKYCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDS HGCLICKCREASASAGPPILSGTCLTVDGHHHKNEESWHDGCRECYCLNGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELS TPSICHAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQDSCCPQCTDQPFRPSLSRNNSVPNYCKNDEGDIFLAA ESWKPDVCTSCICIDSVISCFSESCPSVSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKAYADEERWDLDSCTHCYCLQGQTLCSTVSC PPLPCVEPINVEGSCCPMCPEMYVPEPTNIPIEKTNHRGEVDLEVPLWPTPSENDIVHLPRDMGHLQVDYRDNRLHPSEDSSLDSIASVV VPIIICLSIIIAFLFINQKKQWIPLLCWYRTPTKPSSLNNQLVSVDCKKGTRVQVDSSQRMLRIAEPDARFSGFYSMQKQNHLQADNFYQ -------------------------------------------------------------- >41759_41759_3_KDM3A-CRIM1_KDM3A_chr2_86691339_ENST00000409064_CRIM1_chr2_36691676_ENST00000280527_length(amino acids)=1082AA_BP=336 MVLTLGESWPVLVGRRFLSLSAADGSDGSHDSWDVERVAEWPWLSGTIRAVSHTDVTKKDLKVCVEFDGESWRKRRWIEVYSLLRRAFLV EHNLVLAERKSPEISERIVQWPAITYKPLLDKAGLGSITSVRFLGDQQRVFLSKDLLKPIQDVNSLRLSLTDNQIVSKEFQALIVKHLDE SHLLKGDKNLVGSEVKIYSLDPSTQWFSATVINGNPASKTLQVNCEEIPALKIVDPSLIHVEVVHDNLVTCGNSARIGAVKRKSSENNGT LVSKQAKSCSEASPSMCPVQSVPTTVFKEILLGCTAATPPSKDPRQQSTPQAANSPPNLGAKIPQGCECLSGLCGFPVCEVGSTPRIVSR GDGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINCERYYVPEGECCPVCEDPVYPFNNPAGCY ANGLILAHGDRWREDDCTFCQCVNGERHCVATVCGQTCTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDHNGCR TCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIICDKYCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDS HGCLICKCREASASAGPPILSGTCLTVDGHHHKNEESWHDGCRECYCLNGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELS TPSICHAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQDSCCPQCTDQPFRPSLSRNNSVPNYCKNDEGDIFLAA ESWKPDVCTSCICIDSVISCFSESCPSVSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKAYADEERWDLDSCTHCYCLQGQTLCSTVSC PPLPCVEPINVEGSCCPMCPEMYVPEPTNIPIEKTNHRGEVDLEVPLWPTPSENDIVHLPRDMGHLQVDYRDNRLHPSEDSSLDSIASVV VPIIICLSIIIAFLFINQKKQWIPLLCWYRTPTKPSSLNNQLVSVDCKKGTRVQVDSSQRMLRIAEPDARFSGFYSMQKQNHLQADNFYQ -------------------------------------------------------------- >41759_41759_4_KDM3A-CRIM1_KDM3A_chr2_86691339_ENST00000409064_CRIM1_chr2_36691677_ENST00000280527_length(amino acids)=1082AA_BP=336 MVLTLGESWPVLVGRRFLSLSAADGSDGSHDSWDVERVAEWPWLSGTIRAVSHTDVTKKDLKVCVEFDGESWRKRRWIEVYSLLRRAFLV EHNLVLAERKSPEISERIVQWPAITYKPLLDKAGLGSITSVRFLGDQQRVFLSKDLLKPIQDVNSLRLSLTDNQIVSKEFQALIVKHLDE SHLLKGDKNLVGSEVKIYSLDPSTQWFSATVINGNPASKTLQVNCEEIPALKIVDPSLIHVEVVHDNLVTCGNSARIGAVKRKSSENNGT LVSKQAKSCSEASPSMCPVQSVPTTVFKEILLGCTAATPPSKDPRQQSTPQAANSPPNLGAKIPQGCECLSGLCGFPVCEVGSTPRIVSR GDGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINCERYYVPEGECCPVCEDPVYPFNNPAGCY ANGLILAHGDRWREDDCTFCQCVNGERHCVATVCGQTCTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDHNGCR TCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIICDKYCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDS HGCLICKCREASASAGPPILSGTCLTVDGHHHKNEESWHDGCRECYCLNGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELS TPSICHAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQDSCCPQCTDQPFRPSLSRNNSVPNYCKNDEGDIFLAA ESWKPDVCTSCICIDSVISCFSESCPSVSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKAYADEERWDLDSCTHCYCLQGQTLCSTVSC PPLPCVEPINVEGSCCPMCPEMYVPEPTNIPIEKTNHRGEVDLEVPLWPTPSENDIVHLPRDMGHLQVDYRDNRLHPSEDSSLDSIASVV VPIIICLSIIIAFLFINQKKQWIPLLCWYRTPTKPSSLNNQLVSVDCKKGTRVQVDSSQRMLRIAEPDARFSGFYSMQKQNHLQADNFYQ -------------------------------------------------------------- >41759_41759_5_KDM3A-CRIM1_KDM3A_chr2_86691339_ENST00000409556_CRIM1_chr2_36691676_ENST00000280527_length(amino acids)=1082AA_BP=336 MVLTLGESWPVLVGRRFLSLSAADGSDGSHDSWDVERVAEWPWLSGTIRAVSHTDVTKKDLKVCVEFDGESWRKRRWIEVYSLLRRAFLV EHNLVLAERKSPEISERIVQWPAITYKPLLDKAGLGSITSVRFLGDQQRVFLSKDLLKPIQDVNSLRLSLTDNQIVSKEFQALIVKHLDE SHLLKGDKNLVGSEVKIYSLDPSTQWFSATVINGNPASKTLQVNCEEIPALKIVDPSLIHVEVVHDNLVTCGNSARIGAVKRKSSENNGT LVSKQAKSCSEASPSMCPVQSVPTTVFKEILLGCTAATPPSKDPRQQSTPQAANSPPNLGAKIPQGCECLSGLCGFPVCEVGSTPRIVSR GDGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINCERYYVPEGECCPVCEDPVYPFNNPAGCY ANGLILAHGDRWREDDCTFCQCVNGERHCVATVCGQTCTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDHNGCR TCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIICDKYCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDS HGCLICKCREASASAGPPILSGTCLTVDGHHHKNEESWHDGCRECYCLNGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELS TPSICHAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQDSCCPQCTDQPFRPSLSRNNSVPNYCKNDEGDIFLAA ESWKPDVCTSCICIDSVISCFSESCPSVSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKAYADEERWDLDSCTHCYCLQGQTLCSTVSC PPLPCVEPINVEGSCCPMCPEMYVPEPTNIPIEKTNHRGEVDLEVPLWPTPSENDIVHLPRDMGHLQVDYRDNRLHPSEDSSLDSIASVV VPIIICLSIIIAFLFINQKKQWIPLLCWYRTPTKPSSLNNQLVSVDCKKGTRVQVDSSQRMLRIAEPDARFSGFYSMQKQNHLQADNFYQ -------------------------------------------------------------- >41759_41759_6_KDM3A-CRIM1_KDM3A_chr2_86691339_ENST00000409556_CRIM1_chr2_36691677_ENST00000280527_length(amino acids)=1082AA_BP=336 MVLTLGESWPVLVGRRFLSLSAADGSDGSHDSWDVERVAEWPWLSGTIRAVSHTDVTKKDLKVCVEFDGESWRKRRWIEVYSLLRRAFLV EHNLVLAERKSPEISERIVQWPAITYKPLLDKAGLGSITSVRFLGDQQRVFLSKDLLKPIQDVNSLRLSLTDNQIVSKEFQALIVKHLDE SHLLKGDKNLVGSEVKIYSLDPSTQWFSATVINGNPASKTLQVNCEEIPALKIVDPSLIHVEVVHDNLVTCGNSARIGAVKRKSSENNGT LVSKQAKSCSEASPSMCPVQSVPTTVFKEILLGCTAATPPSKDPRQQSTPQAANSPPNLGAKIPQGCECLSGLCGFPVCEVGSTPRIVSR GDGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINCERYYVPEGECCPVCEDPVYPFNNPAGCY ANGLILAHGDRWREDDCTFCQCVNGERHCVATVCGQTCTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDHNGCR TCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIICDKYCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDS HGCLICKCREASASAGPPILSGTCLTVDGHHHKNEESWHDGCRECYCLNGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELS TPSICHAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQDSCCPQCTDQPFRPSLSRNNSVPNYCKNDEGDIFLAA ESWKPDVCTSCICIDSVISCFSESCPSVSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKAYADEERWDLDSCTHCYCLQGQTLCSTVSC PPLPCVEPINVEGSCCPMCPEMYVPEPTNIPIEKTNHRGEVDLEVPLWPTPSENDIVHLPRDMGHLQVDYRDNRLHPSEDSSLDSIASVV VPIIICLSIIIAFLFINQKKQWIPLLCWYRTPTKPSSLNNQLVSVDCKKGTRVQVDSSQRMLRIAEPDARFSGFYSMQKQNHLQADNFYQ -------------------------------------------------------------- >41759_41759_7_KDM3A-CRIM1_KDM3A_chr2_86691339_ENST00000542128_CRIM1_chr2_36691676_ENST00000280527_length(amino acids)=1030AA_BP=284 MVLTLGESWPVLVGRRFLSLSAADGSDGSHDSWDVERVAEWPWLSGTIRAVSHTDVTKKDLKTYKPLLDKAGLGSITSVRFLGDQQRVFL SKDLLKPIQDVNSLRLSLTDNQIVSKEFQALIVKHLDESHLLKGDKNLVGSEVKIYSLDPSTQWFSATVINGNPASKTLQVNCEEIPALK IVDPSLIHVEVVHDNLVTCGNSARIGAVKRKSSENNGTLVSKQAKSCSEASPSMCPVQSVPTTVFKEILLGCTAATPPSKDPRQQSTPQA ANSPPNLGAKIPQGCECLSGLCGFPVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQGGVAIC FTAQCGEINCERYYVPEGECCPVCEDPVYPFNNPAGCYANGLILAHGDRWREDDCTFCQCVNGERHCVATVCGQTCTNPVKVPGECCPVC EEPTIITVDPPACGELSNCTLTGKDCINGFKRDHNGCRTCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIICDK YCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDSHGCLICKCREASASAGPPILSGTCLTVDGHHHKNEESWHDGCRECYCLNGRE MCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELSTPSICHAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPSRT QDSCCPQCTDQPFRPSLSRNNSVPNYCKNDEGDIFLAAESWKPDVCTSCICIDSVISCFSESCPSVSCERPVLRKGQCCPYCIEDTIPKK VVCHFSGKAYADEERWDLDSCTHCYCLQGQTLCSTVSCPPLPCVEPINVEGSCCPMCPEMYVPEPTNIPIEKTNHRGEVDLEVPLWPTPS ENDIVHLPRDMGHLQVDYRDNRLHPSEDSSLDSIASVVVPIIICLSIIIAFLFINQKKQWIPLLCWYRTPTKPSSLNNQLVSVDCKKGTR -------------------------------------------------------------- >41759_41759_8_KDM3A-CRIM1_KDM3A_chr2_86691339_ENST00000542128_CRIM1_chr2_36691677_ENST00000280527_length(amino acids)=1030AA_BP=284 MVLTLGESWPVLVGRRFLSLSAADGSDGSHDSWDVERVAEWPWLSGTIRAVSHTDVTKKDLKTYKPLLDKAGLGSITSVRFLGDQQRVFL SKDLLKPIQDVNSLRLSLTDNQIVSKEFQALIVKHLDESHLLKGDKNLVGSEVKIYSLDPSTQWFSATVINGNPASKTLQVNCEEIPALK IVDPSLIHVEVVHDNLVTCGNSARIGAVKRKSSENNGTLVSKQAKSCSEASPSMCPVQSVPTTVFKEILLGCTAATPPSKDPRQQSTPQA ANSPPNLGAKIPQGCECLSGLCGFPVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQGGVAIC FTAQCGEINCERYYVPEGECCPVCEDPVYPFNNPAGCYANGLILAHGDRWREDDCTFCQCVNGERHCVATVCGQTCTNPVKVPGECCPVC EEPTIITVDPPACGELSNCTLTGKDCINGFKRDHNGCRTCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIICDK YCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDSHGCLICKCREASASAGPPILSGTCLTVDGHHHKNEESWHDGCRECYCLNGRE MCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELSTPSICHAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPSRT QDSCCPQCTDQPFRPSLSRNNSVPNYCKNDEGDIFLAAESWKPDVCTSCICIDSVISCFSESCPSVSCERPVLRKGQCCPYCIEDTIPKK VVCHFSGKAYADEERWDLDSCTHCYCLQGQTLCSTVSCPPLPCVEPINVEGSCCPMCPEMYVPEPTNIPIEKTNHRGEVDLEVPLWPTPS ENDIVHLPRDMGHLQVDYRDNRLHPSEDSSLDSIASVVVPIIICLSIIIAFLFINQKKQWIPLLCWYRTPTKPSSLNNQLVSVDCKKGTR -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:86691339/chr2:36691677) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
KDM3A | CRIM1 |
FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. {ECO:0000269|PubMed:16603237, ECO:0000269|PubMed:28262558}. | FUNCTION: May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface. {ECO:0000269|PubMed:12464430, ECO:0000269|PubMed:12805376}. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | CRIM1 | chr2:86691339 | chr2:36691676 | ENST00000280527 | 3 | 17 | 334_391 | 289.6666666666667 | 1037.0 | Domain | VWFC 1 | |
Tgene | CRIM1 | chr2:86691339 | chr2:36691676 | ENST00000280527 | 3 | 17 | 401_457 | 289.6666666666667 | 1037.0 | Domain | VWFC 2 | |
Tgene | CRIM1 | chr2:86691339 | chr2:36691676 | ENST00000280527 | 3 | 17 | 469_498 | 289.6666666666667 | 1037.0 | Domain | Antistasin-like 1 | |
Tgene | CRIM1 | chr2:86691339 | chr2:36691676 | ENST00000280527 | 3 | 17 | 505_532 | 289.6666666666667 | 1037.0 | Domain | Antistasin-like 2 | |
Tgene | CRIM1 | chr2:86691339 | chr2:36691676 | ENST00000280527 | 3 | 17 | 539_564 | 289.6666666666667 | 1037.0 | Domain | Antistasin-like 3 | |
Tgene | CRIM1 | chr2:86691339 | chr2:36691676 | ENST00000280527 | 3 | 17 | 567_592 | 289.6666666666667 | 1037.0 | Domain | Antistasin-like 4 | |
Tgene | CRIM1 | chr2:86691339 | chr2:36691676 | ENST00000280527 | 3 | 17 | 606_663 | 289.6666666666667 | 1037.0 | Domain | VWFC 3 | |
Tgene | CRIM1 | chr2:86691339 | chr2:36691676 | ENST00000280527 | 3 | 17 | 677_735 | 289.6666666666667 | 1037.0 | Domain | VWFC 4 | |
Tgene | CRIM1 | chr2:86691339 | chr2:36691676 | ENST00000280527 | 3 | 17 | 751_809 | 289.6666666666667 | 1037.0 | Domain | VWFC 5 | |
Tgene | CRIM1 | chr2:86691339 | chr2:36691676 | ENST00000280527 | 3 | 17 | 817_874 | 289.6666666666667 | 1037.0 | Domain | VWFC 6 | |
Tgene | CRIM1 | chr2:86691339 | chr2:36691677 | ENST00000280527 | 3 | 17 | 334_391 | 289.6666666666667 | 1037.0 | Domain | VWFC 1 | |
Tgene | CRIM1 | chr2:86691339 | chr2:36691677 | ENST00000280527 | 3 | 17 | 401_457 | 289.6666666666667 | 1037.0 | Domain | VWFC 2 | |
Tgene | CRIM1 | chr2:86691339 | chr2:36691677 | ENST00000280527 | 3 | 17 | 469_498 | 289.6666666666667 | 1037.0 | Domain | Antistasin-like 1 | |
Tgene | CRIM1 | chr2:86691339 | chr2:36691677 | ENST00000280527 | 3 | 17 | 505_532 | 289.6666666666667 | 1037.0 | Domain | Antistasin-like 2 | |
Tgene | CRIM1 | chr2:86691339 | chr2:36691677 | ENST00000280527 | 3 | 17 | 539_564 | 289.6666666666667 | 1037.0 | Domain | Antistasin-like 3 | |
Tgene | CRIM1 | chr2:86691339 | chr2:36691677 | ENST00000280527 | 3 | 17 | 567_592 | 289.6666666666667 | 1037.0 | Domain | Antistasin-like 4 | |
Tgene | CRIM1 | chr2:86691339 | chr2:36691677 | ENST00000280527 | 3 | 17 | 606_663 | 289.6666666666667 | 1037.0 | Domain | VWFC 3 | |
Tgene | CRIM1 | chr2:86691339 | chr2:36691677 | ENST00000280527 | 3 | 17 | 677_735 | 289.6666666666667 | 1037.0 | Domain | VWFC 4 | |
Tgene | CRIM1 | chr2:86691339 | chr2:36691677 | ENST00000280527 | 3 | 17 | 751_809 | 289.6666666666667 | 1037.0 | Domain | VWFC 5 | |
Tgene | CRIM1 | chr2:86691339 | chr2:36691677 | ENST00000280527 | 3 | 17 | 817_874 | 289.6666666666667 | 1037.0 | Domain | VWFC 6 | |
Tgene | CRIM1 | chr2:86691339 | chr2:36691676 | ENST00000280527 | 3 | 17 | 314_316 | 289.6666666666667 | 1037.0 | Motif | Cell attachment site | |
Tgene | CRIM1 | chr2:86691339 | chr2:36691677 | ENST00000280527 | 3 | 17 | 314_316 | 289.6666666666667 | 1037.0 | Motif | Cell attachment site | |
Tgene | CRIM1 | chr2:86691339 | chr2:36691676 | ENST00000280527 | 3 | 17 | 961_1036 | 289.6666666666667 | 1037.0 | Topological domain | Cytoplasmic | |
Tgene | CRIM1 | chr2:86691339 | chr2:36691677 | ENST00000280527 | 3 | 17 | 961_1036 | 289.6666666666667 | 1037.0 | Topological domain | Cytoplasmic | |
Tgene | CRIM1 | chr2:86691339 | chr2:36691676 | ENST00000280527 | 3 | 17 | 940_960 | 289.6666666666667 | 1037.0 | Transmembrane | Helical | |
Tgene | CRIM1 | chr2:86691339 | chr2:36691677 | ENST00000280527 | 3 | 17 | 940_960 | 289.6666666666667 | 1037.0 | Transmembrane | Helical |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | KDM3A | chr2:86691339 | chr2:36691676 | ENST00000312912 | + | 9 | 26 | 1058_1281 | 335.6666666666667 | 1322.0 | Domain | JmjC |
Hgene | KDM3A | chr2:86691339 | chr2:36691676 | ENST00000409064 | + | 9 | 26 | 1058_1281 | 335.6666666666667 | 1322.0 | Domain | JmjC |
Hgene | KDM3A | chr2:86691339 | chr2:36691676 | ENST00000409556 | + | 10 | 27 | 1058_1281 | 335.6666666666667 | 1322.0 | Domain | JmjC |
Hgene | KDM3A | chr2:86691339 | chr2:36691677 | ENST00000312912 | + | 9 | 26 | 1058_1281 | 335.6666666666667 | 1322.0 | Domain | JmjC |
Hgene | KDM3A | chr2:86691339 | chr2:36691677 | ENST00000409064 | + | 9 | 26 | 1058_1281 | 335.6666666666667 | 1322.0 | Domain | JmjC |
Hgene | KDM3A | chr2:86691339 | chr2:36691677 | ENST00000409556 | + | 10 | 27 | 1058_1281 | 335.6666666666667 | 1322.0 | Domain | JmjC |
Hgene | KDM3A | chr2:86691339 | chr2:36691676 | ENST00000312912 | + | 9 | 26 | 885_889 | 335.6666666666667 | 1322.0 | Motif | Note=LXXLL motif |
Hgene | KDM3A | chr2:86691339 | chr2:36691676 | ENST00000409064 | + | 9 | 26 | 885_889 | 335.6666666666667 | 1322.0 | Motif | Note=LXXLL motif |
Hgene | KDM3A | chr2:86691339 | chr2:36691676 | ENST00000409556 | + | 10 | 27 | 885_889 | 335.6666666666667 | 1322.0 | Motif | Note=LXXLL motif |
Hgene | KDM3A | chr2:86691339 | chr2:36691677 | ENST00000312912 | + | 9 | 26 | 885_889 | 335.6666666666667 | 1322.0 | Motif | Note=LXXLL motif |
Hgene | KDM3A | chr2:86691339 | chr2:36691677 | ENST00000409064 | + | 9 | 26 | 885_889 | 335.6666666666667 | 1322.0 | Motif | Note=LXXLL motif |
Hgene | KDM3A | chr2:86691339 | chr2:36691677 | ENST00000409556 | + | 10 | 27 | 885_889 | 335.6666666666667 | 1322.0 | Motif | Note=LXXLL motif |
Hgene | KDM3A | chr2:86691339 | chr2:36691676 | ENST00000312912 | + | 9 | 26 | 662_687 | 335.6666666666667 | 1322.0 | Zinc finger | C6-type |
Hgene | KDM3A | chr2:86691339 | chr2:36691676 | ENST00000409064 | + | 9 | 26 | 662_687 | 335.6666666666667 | 1322.0 | Zinc finger | C6-type |
Hgene | KDM3A | chr2:86691339 | chr2:36691676 | ENST00000409556 | + | 10 | 27 | 662_687 | 335.6666666666667 | 1322.0 | Zinc finger | C6-type |
Hgene | KDM3A | chr2:86691339 | chr2:36691677 | ENST00000312912 | + | 9 | 26 | 662_687 | 335.6666666666667 | 1322.0 | Zinc finger | C6-type |
Hgene | KDM3A | chr2:86691339 | chr2:36691677 | ENST00000409064 | + | 9 | 26 | 662_687 | 335.6666666666667 | 1322.0 | Zinc finger | C6-type |
Hgene | KDM3A | chr2:86691339 | chr2:36691677 | ENST00000409556 | + | 10 | 27 | 662_687 | 335.6666666666667 | 1322.0 | Zinc finger | C6-type |
Tgene | CRIM1 | chr2:86691339 | chr2:36691676 | ENST00000280527 | 3 | 17 | 35_112 | 289.6666666666667 | 1037.0 | Domain | IGFBP N-terminal | |
Tgene | CRIM1 | chr2:86691339 | chr2:36691677 | ENST00000280527 | 3 | 17 | 35_112 | 289.6666666666667 | 1037.0 | Domain | IGFBP N-terminal | |
Tgene | CRIM1 | chr2:86691339 | chr2:36691676 | ENST00000280527 | 3 | 17 | 35_939 | 289.6666666666667 | 1037.0 | Topological domain | Extracellular | |
Tgene | CRIM1 | chr2:86691339 | chr2:36691677 | ENST00000280527 | 3 | 17 | 35_939 | 289.6666666666667 | 1037.0 | Topological domain | Extracellular |
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Fusion Protein Structures |
![]() * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
PDB file >>>1852_KDM3A_86691339_CRIM1_36691677_ranked_0.pdb | KDM3A | 86691339 | 86691339 | ENST00000280527 | CRIM1 | chr2 | 36691677 | + | MVLTLGESWPVLVGRRFLSLSAADGSDGSHDSWDVERVAEWPWLSGTIRAVSHTDVTKKDLKVCVEFDGESWRKRRWIEVYSLLRRAFLV EHNLVLAERKSPEISERIVQWPAITYKPLLDKAGLGSITSVRFLGDQQRVFLSKDLLKPIQDVNSLRLSLTDNQIVSKEFQALIVKHLDE SHLLKGDKNLVGSEVKIYSLDPSTQWFSATVINGNPASKTLQVNCEEIPALKIVDPSLIHVEVVHDNLVTCGNSARIGAVKRKSSENNGT LVSKQAKSCSEASPSMCPVQSVPTTVFKEILLGCTAATPPSKDPRQQSTPQAANSPPNLGAKIPQGCECLSGLCGFPVCEVGSTPRIVSR GDGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINCERYYVPEGECCPVCEDPVYPFNNPAGCY ANGLILAHGDRWREDDCTFCQCVNGERHCVATVCGQTCTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDHNGCR TCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIICDKYCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDS HGCLICKCREASASAGPPILSGTCLTVDGHHHKNEESWHDGCRECYCLNGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELS TPSICHAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQDSCCPQCTDQPFRPSLSRNNSVPNYCKNDEGDIFLAA ESWKPDVCTSCICIDSVISCFSESCPSVSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKAYADEERWDLDSCTHCYCLQGQTLCSTVSC PPLPCVEPINVEGSCCPMCPEMYVPEPTNIPIEKTNHRGEVDLEVPLWPTPSENDIVHLPRDMGHLQVDYRDNRLHPSEDSSLDSIASVV VPIIICLSIIIAFLFINQKKQWIPLLCWYRTPTKPSSLNNQLVSVDCKKGTRVQVDSSQRMLRIAEPDARFSGFYSMQKQNHLQADNFYQ | 1082 |
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pLDDT score distribution |
![]() * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
KDM3A_pLDDT.png![]() |
CRIM1_pLDDT.png![]() |
![]() * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
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Ramachandran Plot of Fusion Protein Structure |
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Fusion AA seq ID in FusionPDB and their Ramachandran plots |
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Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
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Gene | STRING network |
KDM3A | |
CRIM1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to KDM3A-CRIM1 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to KDM3A-CRIM1 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |