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Fusion Protein:KDM5B-ITPKB |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: KDM5B-ITPKB | FusionPDB ID: 41860 | FusionGDB2.0 ID: 41860 | Hgene | Tgene | Gene symbol | KDM5B | ITPKB | Gene ID | 10765 | 3707 |
Gene name | lysine demethylase 5B | inositol-trisphosphate 3-kinase B | |
Synonyms | CT31|JARID1B|MRT65|PLU-1|PLU1|PPP1R98|PUT1|RBBP2H1A|RBP2-H1 | IP3-3KB|IP3K|IP3K-B|IP3KB|PIG37 | |
Cytomap | 1q32.1 | 1q42.12 | |
Type of gene | protein-coding | protein-coding | |
Description | lysine-specific demethylase 5Bcancer/testis antigen 31histone demethylase JARID1Bjumonji, AT rich interactive domain 1Bjumonji/ARID domain-containing protein 1Blysine (K)-specific demethylase 5Bprotein phosphatase 1, regulatory subunit 98putative D | inositol-trisphosphate 3-kinase BIP3 3-kinase BIP3K Binositol 1,4,5-trisphosphate 3-kinase BinsP 3-kinase Bproliferation-inducing protein 37 | |
Modification date | 20200320 | 20200313 | |
UniProtAcc | Q9UGL1 | P27987 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000367264, ENST00000367265, ENST00000456180, | ENST00000366784, ENST00000272117, ENST00000429204, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 14 X 13 X 9=1638 | 12 X 10 X 3=360 |
# samples | 17 | 13 | |
** MAII score | log2(17/1638*10)=-3.26832870550331 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/360*10)=-1.46948528330122 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: KDM5B [Title/Abstract] AND ITPKB [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | KDM5B(202742246)-ITPKB(226836472), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | KDM5B-ITPKB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KDM5B-ITPKB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KDM5B-ITPKB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KDM5B-ITPKB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | KDM5B | GO:0034720 | histone H3-K4 demethylation | 20228790 |
Tgene | ITPKB | GO:0032957 | inositol trisphosphate metabolic process | 1654894 |
Tgene | ITPKB | GO:0071277 | cellular response to calcium ion | 1654894 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | PCPG | TCGA-WB-A81J-01A | KDM5B | chr1 | 202742246 | - | ITPKB | chr1 | 226836472 | - |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000367265 | KDM5B | chr1 | 202742246 | - | ENST00000272117 | ITPKB | chr1 | 226836472 | - | 5631 | 1741 | 934 | 2649 | 571 |
ENST00000367265 | KDM5B | chr1 | 202742246 | - | ENST00000429204 | ITPKB | chr1 | 226836472 | - | 5631 | 1741 | 934 | 2649 | 571 |
ENST00000367264 | KDM5B | chr1 | 202742246 | - | ENST00000272117 | ITPKB | chr1 | 226836472 | - | 4579 | 689 | 113 | 1597 | 494 |
ENST00000367264 | KDM5B | chr1 | 202742246 | - | ENST00000429204 | ITPKB | chr1 | 226836472 | - | 4579 | 689 | 113 | 1597 | 494 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000367265 | ENST00000272117 | KDM5B | chr1 | 202742246 | - | ITPKB | chr1 | 226836472 | - | 0.004755261 | 0.9952447 |
ENST00000367265 | ENST00000429204 | KDM5B | chr1 | 202742246 | - | ITPKB | chr1 | 226836472 | - | 0.004755261 | 0.9952447 |
ENST00000367264 | ENST00000272117 | KDM5B | chr1 | 202742246 | - | ITPKB | chr1 | 226836472 | - | 0.002242655 | 0.9977574 |
ENST00000367264 | ENST00000429204 | KDM5B | chr1 | 202742246 | - | ITPKB | chr1 | 226836472 | - | 0.002242655 | 0.9977574 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >41860_41860_1_KDM5B-ITPKB_KDM5B_chr1_202742246_ENST00000367264_ITPKB_chr1_226836472_ENST00000272117_length(amino acids)=494AA_BP=192 MEAATTLHPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRL NELEAQTRVKLNFLDQIAKYWELQGSTLKIPHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILN PYNLFLSGDSLRSKSWRKIKNMVHWSPFVMSFKKKYPWIQLAGHAGSFKAAANGRILKKHCESEQRCLDRLMVDVLRPFVPAYHGDVVKD GERYNQMDDLLADFDSPCVMDCKMGIRTYLEEELTKARKKPSLRKDMYQKMIEVDPEAPTEEEKAQRAVTKPRYMQWRETISSTATLGFR IEGIKKEDGTVNRDFKKTKTREQVTEAFREFTKGNHNILIAYRDRLKAIRTTLEVSPFFKCHEVIGSSLLFIHDKKEQAKVWMIDFGKTT -------------------------------------------------------------- >41860_41860_2_KDM5B-ITPKB_KDM5B_chr1_202742246_ENST00000367264_ITPKB_chr1_226836472_ENST00000429204_length(amino acids)=494AA_BP=192 MEAATTLHPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRL NELEAQTRVKLNFLDQIAKYWELQGSTLKIPHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILN PYNLFLSGDSLRSKSWRKIKNMVHWSPFVMSFKKKYPWIQLAGHAGSFKAAANGRILKKHCESEQRCLDRLMVDVLRPFVPAYHGDVVKD GERYNQMDDLLADFDSPCVMDCKMGIRTYLEEELTKARKKPSLRKDMYQKMIEVDPEAPTEEEKAQRAVTKPRYMQWRETISSTATLGFR IEGIKKEDGTVNRDFKKTKTREQVTEAFREFTKGNHNILIAYRDRLKAIRTTLEVSPFFKCHEVIGSSLLFIHDKKEQAKVWMIDFGKTT -------------------------------------------------------------- >41860_41860_3_KDM5B-ITPKB_KDM5B_chr1_202742246_ENST00000367265_ITPKB_chr1_226836472_ENST00000272117_length(amino acids)=571AA_BP=269 MGVGWDSFSSPWRRRRTAWACGETSSSEAEKAQGAAVARTTRTCCCSSRVCTGLGPSGARSLGPGAHLRLALAQPAVMEAATTLHPGPRP ALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNF LDQIAKYWELQGSTLKIPHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILNPYNLFLSGDSLRS KSWRKIKNMVHWSPFVMSFKKKYPWIQLAGHAGSFKAAANGRILKKHCESEQRCLDRLMVDVLRPFVPAYHGDVVKDGERYNQMDDLLAD FDSPCVMDCKMGIRTYLEEELTKARKKPSLRKDMYQKMIEVDPEAPTEEEKAQRAVTKPRYMQWRETISSTATLGFRIEGIKKEDGTVNR DFKKTKTREQVTEAFREFTKGNHNILIAYRDRLKAIRTTLEVSPFFKCHEVIGSSLLFIHDKKEQAKVWMIDFGKTTPLPEGQTLQHDVP -------------------------------------------------------------- >41860_41860_4_KDM5B-ITPKB_KDM5B_chr1_202742246_ENST00000367265_ITPKB_chr1_226836472_ENST00000429204_length(amino acids)=571AA_BP=269 MGVGWDSFSSPWRRRRTAWACGETSSSEAEKAQGAAVARTTRTCCCSSRVCTGLGPSGARSLGPGAHLRLALAQPAVMEAATTLHPGPRP ALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNF LDQIAKYWELQGSTLKIPHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILNPYNLFLSGDSLRS KSWRKIKNMVHWSPFVMSFKKKYPWIQLAGHAGSFKAAANGRILKKHCESEQRCLDRLMVDVLRPFVPAYHGDVVKDGERYNQMDDLLAD FDSPCVMDCKMGIRTYLEEELTKARKKPSLRKDMYQKMIEVDPEAPTEEEKAQRAVTKPRYMQWRETISSTATLGFRIEGIKKEDGTVNR DFKKTKTREQVTEAFREFTKGNHNILIAYRDRLKAIRTTLEVSPFFKCHEVIGSSLLFIHDKKEQAKVWMIDFGKTTPLPEGQTLQHDVP -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:202742246/chr1:226836472) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
KDM5B | ITPKB |
FUNCTION: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558). Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 (PubMed:24952722). In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:Q80Y84, ECO:0000269|PubMed:12657635, ECO:0000269|PubMed:16645588, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17363312, ECO:0000269|PubMed:24952722, ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:26741168, ECO:0000269|PubMed:27214403, ECO:0000269|PubMed:28262558}. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | KDM5B | chr1:202742246 | chr1:226836472 | ENST00000367264 | - | 4 | 28 | 32_73 | 192.0 | 1581.0 | Domain | JmjN |
Hgene | KDM5B | chr1:202742246 | chr1:226836472 | ENST00000367264 | - | 4 | 28 | 97_187 | 192.0 | 1581.0 | Domain | ARID |
Hgene | KDM5B | chr1:202742246 | chr1:226836472 | ENST00000367265 | - | 4 | 27 | 32_73 | 192.0 | 1545.0 | Domain | JmjN |
Hgene | KDM5B | chr1:202742246 | chr1:226836472 | ENST00000367265 | - | 4 | 27 | 97_187 | 192.0 | 1545.0 | Domain | ARID |
Tgene | ITPKB | chr1:202742246 | chr1:226836472 | ENST00000366784 | 0 | 3 | 599_605 | 0 | 645.0 | Compositional bias | Note=Poly-Ser | |
Tgene | ITPKB | chr1:202742246 | chr1:226836472 | ENST00000272117 | 0 | 7 | 730_732 | 644.0 | 947.0 | Nucleotide binding | ATP | |
Tgene | ITPKB | chr1:202742246 | chr1:226836472 | ENST00000366784 | 0 | 3 | 730_732 | 0 | 645.0 | Nucleotide binding | ATP | |
Tgene | ITPKB | chr1:202742246 | chr1:226836472 | ENST00000429204 | 1 | 8 | 730_732 | 644.0 | 947.0 | Nucleotide binding | ATP | |
Tgene | ITPKB | chr1:202742246 | chr1:226836472 | ENST00000272117 | 0 | 7 | 768_776 | 644.0 | 947.0 | Region | Calmodulin-binding | |
Tgene | ITPKB | chr1:202742246 | chr1:226836472 | ENST00000272117 | 0 | 7 | 793_800 | 644.0 | 947.0 | Region | Substrate binding | |
Tgene | ITPKB | chr1:202742246 | chr1:226836472 | ENST00000366784 | 0 | 3 | 768_776 | 0 | 645.0 | Region | Calmodulin-binding | |
Tgene | ITPKB | chr1:202742246 | chr1:226836472 | ENST00000366784 | 0 | 3 | 793_800 | 0 | 645.0 | Region | Substrate binding | |
Tgene | ITPKB | chr1:202742246 | chr1:226836472 | ENST00000429204 | 1 | 8 | 768_776 | 644.0 | 947.0 | Region | Calmodulin-binding | |
Tgene | ITPKB | chr1:202742246 | chr1:226836472 | ENST00000429204 | 1 | 8 | 793_800 | 644.0 | 947.0 | Region | Substrate binding |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | KDM5B | chr1:202742246 | chr1:226836472 | ENST00000367264 | - | 4 | 28 | 1434_1439 | 192.0 | 1581.0 | Compositional bias | Note=Poly-Lys |
Hgene | KDM5B | chr1:202742246 | chr1:226836472 | ENST00000367265 | - | 4 | 27 | 1434_1439 | 192.0 | 1545.0 | Compositional bias | Note=Poly-Lys |
Hgene | KDM5B | chr1:202742246 | chr1:226836472 | ENST00000367264 | - | 4 | 28 | 453_619 | 192.0 | 1581.0 | Domain | JmjC |
Hgene | KDM5B | chr1:202742246 | chr1:226836472 | ENST00000367265 | - | 4 | 27 | 453_619 | 192.0 | 1545.0 | Domain | JmjC |
Hgene | KDM5B | chr1:202742246 | chr1:226836472 | ENST00000367264 | - | 4 | 28 | 1176_1224 | 192.0 | 1581.0 | Zinc finger | PHD-type 2 |
Hgene | KDM5B | chr1:202742246 | chr1:226836472 | ENST00000367264 | - | 4 | 28 | 1484_1538 | 192.0 | 1581.0 | Zinc finger | PHD-type 3 |
Hgene | KDM5B | chr1:202742246 | chr1:226836472 | ENST00000367264 | - | 4 | 28 | 309_359 | 192.0 | 1581.0 | Zinc finger | PHD-type 1 |
Hgene | KDM5B | chr1:202742246 | chr1:226836472 | ENST00000367264 | - | 4 | 28 | 692_744 | 192.0 | 1581.0 | Zinc finger | C5HC2 |
Hgene | KDM5B | chr1:202742246 | chr1:226836472 | ENST00000367265 | - | 4 | 27 | 1176_1224 | 192.0 | 1545.0 | Zinc finger | PHD-type 2 |
Hgene | KDM5B | chr1:202742246 | chr1:226836472 | ENST00000367265 | - | 4 | 27 | 1484_1538 | 192.0 | 1545.0 | Zinc finger | PHD-type 3 |
Hgene | KDM5B | chr1:202742246 | chr1:226836472 | ENST00000367265 | - | 4 | 27 | 309_359 | 192.0 | 1545.0 | Zinc finger | PHD-type 1 |
Hgene | KDM5B | chr1:202742246 | chr1:226836472 | ENST00000367265 | - | 4 | 27 | 692_744 | 192.0 | 1545.0 | Zinc finger | C5HC2 |
Tgene | ITPKB | chr1:202742246 | chr1:226836472 | ENST00000272117 | 0 | 7 | 599_605 | 644.0 | 947.0 | Compositional bias | Note=Poly-Ser | |
Tgene | ITPKB | chr1:202742246 | chr1:226836472 | ENST00000429204 | 1 | 8 | 599_605 | 644.0 | 947.0 | Compositional bias | Note=Poly-Ser |
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Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
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Gene | STRING network |
KDM5B | |
ITPKB |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to KDM5B-ITPKB |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to KDM5B-ITPKB |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |