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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:KDM6A-ZNF674

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KDM6A-ZNF674
FusionPDB ID: 41916
FusionGDB2.0 ID: 41916
HgeneTgene
Gene symbol

KDM6A

ZNF674

Gene ID

7403

641339

Gene namelysine demethylase 6Azinc finger protein 674
SynonymsKABUK2|UTX|bA386N14.2MRX92|ZNF673B
Cytomap

Xp11.3

Xp11.3

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 6AbA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX))histone demethylase UTXlysine (K)-specific demethylase 6Aubiquitously transcribed tetratricopeptide repeat protein X-linkedubiquitozinc finger protein 674zinc finger family member 674
Modification date2020031320200313
UniProtAcc

O15550

.
Ensembl transtripts involved in fusion geneENST idsENST00000377967, ENST00000382899, 
ENST00000536777, ENST00000543216, 
ENST00000479423, 		ENST00000518795, 
ENST00000523374, ENST00000414387, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score19 X 9 X 11=18811 X 2 X 1=2
# samples 201
** MAII scorelog2(20/1881*10)=-3.23342794374847
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/2*10)=2.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: KDM6A [Title/Abstract] AND ZNF674 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KDM6A(44733233)-ZNF674(46360770), # samples:3
Anticipated loss of major functional domain due to fusion event.KDM6A-ZNF674 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM6A-ZNF674 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM6A-ZNF674 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM6A-ZNF674 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM6A-ZNF674 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
KDM6A-ZNF674 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KDM6A-ZNF674 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KDM6A-ZNF674 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KDM6A-ZNF674 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
KDM6A-ZNF674 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across KDM6A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZNF674 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-71-6725-01AKDM6AchrX

44733233

+ZNF674chrX

46360767

-
ChimerDB4LUADTCGA-71-6725-01AKDM6AchrX

44733233

-ZNF674chrX

46360770

-
ChimerDB4LUADTCGA-71-6725-01AKDM6AchrX

44733233

+ZNF674chrX

46360770

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000377967KDM6AchrX44733233+ENST00000414387ZNF674chrX46360770-21622663191755478
ENST00000382899KDM6AchrX44733233+ENST00000414387ZNF674chrX46360770-21382422951731478
ENST00000536777KDM6AchrX44733233+ENST00000414387ZNF674chrX46360770-21382422951731478
ENST00000543216KDM6AchrX44733233+ENST00000414387ZNF674chrX46360770-21212252781714478
ENST00000377967KDM6AchrX44733233+ENST00000414387ZNF674chrX46360767-21622663191755478
ENST00000382899KDM6AchrX44733233+ENST00000414387ZNF674chrX46360767-21382422951731478
ENST00000536777KDM6AchrX44733233+ENST00000414387ZNF674chrX46360767-21382422951731478
ENST00000543216KDM6AchrX44733233+ENST00000414387ZNF674chrX46360767-21212252781714478

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377967ENST00000414387KDM6AchrX44733233+ZNF674chrX46360770-0.0303366040.9696633
ENST00000382899ENST00000414387KDM6AchrX44733233+ZNF674chrX46360770-0.036954980.96304506
ENST00000536777ENST00000414387KDM6AchrX44733233+ZNF674chrX46360770-0.036954980.96304506
ENST00000543216ENST00000414387KDM6AchrX44733233+ZNF674chrX46360770-0.0621040950.93789583
ENST00000377967ENST00000414387KDM6AchrX44733233+ZNF674chrX46360767-0.0303366040.9696633
ENST00000382899ENST00000414387KDM6AchrX44733233+ZNF674chrX46360767-0.036954980.96304506
ENST00000536777ENST00000414387KDM6AchrX44733233+ZNF674chrX46360767-0.036954980.96304506
ENST00000543216ENST00000414387KDM6AchrX44733233+ZNF674chrX46360767-0.0621040950.93789583

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>41916_41916_1_KDM6A-ZNF674_KDM6A_chrX_44733233_ENST00000377967_ZNF674_chrX_46360767_ENST00000414387_length(amino acids)=478AA_BP=115
MWQAAFIGKETLKDESGQECKICRKIIYLNTDFVSVKQRLPKYYSWERCSKHHLNFLGQNRSYVRKKDDGCKAYWKVCLHYNLHKAQPAE
RFFDPNQRGKALHQKQALRKSQRSQTGEKLYKCTECGKVFIQKANLVVHQRTHTGEKPYECCECAKAFSQKSTLIAHQRTHTGEKPYECS
ECGKTFIQKSTLIKHQRTHTGEKPFVCDKCPKAFKSSYHLIRHEKTHIRQAFYKGIKCTTSSLIYQRIHTSEKPQCSEHGKASDEKPSPT
KHWRTHTKENIYECSKCGKSFRGKSHLSVHQRIHTGEKPYECSICGKTFSGKSHLSVHHRTHTGEKPYECRRCGKAFGEKSTLIVHQRMH
TGEKPYKCNECGKAFSEKSPLIKHQRIHTGERPYECTDCKKAFSRKSTLIKHQRIHTGEKPYKCSECGKAFSVKSTLIVHHRTHTGEKPY

--------------------------------------------------------------

>41916_41916_2_KDM6A-ZNF674_KDM6A_chrX_44733233_ENST00000377967_ZNF674_chrX_46360770_ENST00000414387_length(amino acids)=478AA_BP=115
MWQAAFIGKETLKDESGQECKICRKIIYLNTDFVSVKQRLPKYYSWERCSKHHLNFLGQNRSYVRKKDDGCKAYWKVCLHYNLHKAQPAE
RFFDPNQRGKALHQKQALRKSQRSQTGEKLYKCTECGKVFIQKANLVVHQRTHTGEKPYECCECAKAFSQKSTLIAHQRTHTGEKPYECS
ECGKTFIQKSTLIKHQRTHTGEKPFVCDKCPKAFKSSYHLIRHEKTHIRQAFYKGIKCTTSSLIYQRIHTSEKPQCSEHGKASDEKPSPT
KHWRTHTKENIYECSKCGKSFRGKSHLSVHQRIHTGEKPYECSICGKTFSGKSHLSVHHRTHTGEKPYECRRCGKAFGEKSTLIVHQRMH
TGEKPYKCNECGKAFSEKSPLIKHQRIHTGERPYECTDCKKAFSRKSTLIKHQRIHTGEKPYKCSECGKAFSVKSTLIVHHRTHTGEKPY

--------------------------------------------------------------

>41916_41916_3_KDM6A-ZNF674_KDM6A_chrX_44733233_ENST00000382899_ZNF674_chrX_46360767_ENST00000414387_length(amino acids)=478AA_BP=115
MWQAAFIGKETLKDESGQECKICRKIIYLNTDFVSVKQRLPKYYSWERCSKHHLNFLGQNRSYVRKKDDGCKAYWKVCLHYNLHKAQPAE
RFFDPNQRGKALHQKQALRKSQRSQTGEKLYKCTECGKVFIQKANLVVHQRTHTGEKPYECCECAKAFSQKSTLIAHQRTHTGEKPYECS
ECGKTFIQKSTLIKHQRTHTGEKPFVCDKCPKAFKSSYHLIRHEKTHIRQAFYKGIKCTTSSLIYQRIHTSEKPQCSEHGKASDEKPSPT
KHWRTHTKENIYECSKCGKSFRGKSHLSVHQRIHTGEKPYECSICGKTFSGKSHLSVHHRTHTGEKPYECRRCGKAFGEKSTLIVHQRMH
TGEKPYKCNECGKAFSEKSPLIKHQRIHTGERPYECTDCKKAFSRKSTLIKHQRIHTGEKPYKCSECGKAFSVKSTLIVHHRTHTGEKPY

--------------------------------------------------------------

>41916_41916_4_KDM6A-ZNF674_KDM6A_chrX_44733233_ENST00000382899_ZNF674_chrX_46360770_ENST00000414387_length(amino acids)=478AA_BP=115
MWQAAFIGKETLKDESGQECKICRKIIYLNTDFVSVKQRLPKYYSWERCSKHHLNFLGQNRSYVRKKDDGCKAYWKVCLHYNLHKAQPAE
RFFDPNQRGKALHQKQALRKSQRSQTGEKLYKCTECGKVFIQKANLVVHQRTHTGEKPYECCECAKAFSQKSTLIAHQRTHTGEKPYECS
ECGKTFIQKSTLIKHQRTHTGEKPFVCDKCPKAFKSSYHLIRHEKTHIRQAFYKGIKCTTSSLIYQRIHTSEKPQCSEHGKASDEKPSPT
KHWRTHTKENIYECSKCGKSFRGKSHLSVHQRIHTGEKPYECSICGKTFSGKSHLSVHHRTHTGEKPYECRRCGKAFGEKSTLIVHQRMH
TGEKPYKCNECGKAFSEKSPLIKHQRIHTGERPYECTDCKKAFSRKSTLIKHQRIHTGEKPYKCSECGKAFSVKSTLIVHHRTHTGEKPY

--------------------------------------------------------------

>41916_41916_5_KDM6A-ZNF674_KDM6A_chrX_44733233_ENST00000536777_ZNF674_chrX_46360767_ENST00000414387_length(amino acids)=478AA_BP=115
MWQAAFIGKETLKDESGQECKICRKIIYLNTDFVSVKQRLPKYYSWERCSKHHLNFLGQNRSYVRKKDDGCKAYWKVCLHYNLHKAQPAE
RFFDPNQRGKALHQKQALRKSQRSQTGEKLYKCTECGKVFIQKANLVVHQRTHTGEKPYECCECAKAFSQKSTLIAHQRTHTGEKPYECS
ECGKTFIQKSTLIKHQRTHTGEKPFVCDKCPKAFKSSYHLIRHEKTHIRQAFYKGIKCTTSSLIYQRIHTSEKPQCSEHGKASDEKPSPT
KHWRTHTKENIYECSKCGKSFRGKSHLSVHQRIHTGEKPYECSICGKTFSGKSHLSVHHRTHTGEKPYECRRCGKAFGEKSTLIVHQRMH
TGEKPYKCNECGKAFSEKSPLIKHQRIHTGERPYECTDCKKAFSRKSTLIKHQRIHTGEKPYKCSECGKAFSVKSTLIVHHRTHTGEKPY

--------------------------------------------------------------

>41916_41916_6_KDM6A-ZNF674_KDM6A_chrX_44733233_ENST00000536777_ZNF674_chrX_46360770_ENST00000414387_length(amino acids)=478AA_BP=115
MWQAAFIGKETLKDESGQECKICRKIIYLNTDFVSVKQRLPKYYSWERCSKHHLNFLGQNRSYVRKKDDGCKAYWKVCLHYNLHKAQPAE
RFFDPNQRGKALHQKQALRKSQRSQTGEKLYKCTECGKVFIQKANLVVHQRTHTGEKPYECCECAKAFSQKSTLIAHQRTHTGEKPYECS
ECGKTFIQKSTLIKHQRTHTGEKPFVCDKCPKAFKSSYHLIRHEKTHIRQAFYKGIKCTTSSLIYQRIHTSEKPQCSEHGKASDEKPSPT
KHWRTHTKENIYECSKCGKSFRGKSHLSVHQRIHTGEKPYECSICGKTFSGKSHLSVHHRTHTGEKPYECRRCGKAFGEKSTLIVHQRMH
TGEKPYKCNECGKAFSEKSPLIKHQRIHTGERPYECTDCKKAFSRKSTLIKHQRIHTGEKPYKCSECGKAFSVKSTLIVHHRTHTGEKPY

--------------------------------------------------------------

>41916_41916_7_KDM6A-ZNF674_KDM6A_chrX_44733233_ENST00000543216_ZNF674_chrX_46360767_ENST00000414387_length(amino acids)=478AA_BP=115
MWQAAFIGKETLKDESGQECKICRKIIYLNTDFVSVKQRLPKYYSWERCSKHHLNFLGQNRSYVRKKDDGCKAYWKVCLHYNLHKAQPAE
RFFDPNQRGKALHQKQALRKSQRSQTGEKLYKCTECGKVFIQKANLVVHQRTHTGEKPYECCECAKAFSQKSTLIAHQRTHTGEKPYECS
ECGKTFIQKSTLIKHQRTHTGEKPFVCDKCPKAFKSSYHLIRHEKTHIRQAFYKGIKCTTSSLIYQRIHTSEKPQCSEHGKASDEKPSPT
KHWRTHTKENIYECSKCGKSFRGKSHLSVHQRIHTGEKPYECSICGKTFSGKSHLSVHHRTHTGEKPYECRRCGKAFGEKSTLIVHQRMH
TGEKPYKCNECGKAFSEKSPLIKHQRIHTGERPYECTDCKKAFSRKSTLIKHQRIHTGEKPYKCSECGKAFSVKSTLIVHHRTHTGEKPY

--------------------------------------------------------------

>41916_41916_8_KDM6A-ZNF674_KDM6A_chrX_44733233_ENST00000543216_ZNF674_chrX_46360770_ENST00000414387_length(amino acids)=478AA_BP=115
MWQAAFIGKETLKDESGQECKICRKIIYLNTDFVSVKQRLPKYYSWERCSKHHLNFLGQNRSYVRKKDDGCKAYWKVCLHYNLHKAQPAE
RFFDPNQRGKALHQKQALRKSQRSQTGEKLYKCTECGKVFIQKANLVVHQRTHTGEKPYECCECAKAFSQKSTLIAHQRTHTGEKPYECS
ECGKTFIQKSTLIKHQRTHTGEKPFVCDKCPKAFKSSYHLIRHEKTHIRQAFYKGIKCTTSSLIYQRIHTSEKPQCSEHGKASDEKPSPT
KHWRTHTKENIYECSKCGKSFRGKSHLSVHQRIHTGEKPYECSICGKTFSGKSHLSVHHRTHTGEKPYECRRCGKAFGEKSTLIVHQRMH
TGEKPYKCNECGKAFSEKSPLIKHQRIHTGERPYECTDCKKAFSRKSTLIKHQRIHTGEKPYKCSECGKAFSVKSTLIVHHRTHTGEKPY

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:44733233/chrX:46360770)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM6A

O15550

.
FUNCTION: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17851529, PubMed:17713478, PubMed:17761849). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17851529, PubMed:17713478, PubMed:17761849). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity). {ECO:0000250|UniProtKB:O70546, ECO:0000269|PubMed:17713478, ECO:0000269|PubMed:17761849, ECO:0000269|PubMed:17851529, ECO:0000269|PubMed:18003914}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM6AchrX:44733233chrX:46360767ENST00000377967+2299_1775.01402.0Compositional biasNote=Poly-Ala
HgeneKDM6AchrX:44733233chrX:46360770ENST00000377967+2299_1775.01402.0Compositional biasNote=Poly-Ala
TgeneZNF674chrX:44733233chrX:46360767ENST0000041438735224_24679.33333333333333576.0Zinc fingerC2H2-type 1
TgeneZNF674chrX:44733233chrX:46360767ENST0000041438735252_27479.33333333333333576.0Zinc fingerC2H2-type 2
TgeneZNF674chrX:44733233chrX:46360767ENST0000041438735280_30279.33333333333333576.0Zinc fingerC2H2-type 3
TgeneZNF674chrX:44733233chrX:46360767ENST0000041438735308_33079.33333333333333576.0Zinc fingerC2H2-type 4
TgeneZNF674chrX:44733233chrX:46360767ENST0000041438735385_40779.33333333333333576.0Zinc fingerC2H2-type 5
TgeneZNF674chrX:44733233chrX:46360767ENST0000041438735413_43579.33333333333333576.0Zinc fingerC2H2-type 6
TgeneZNF674chrX:44733233chrX:46360767ENST0000041438735441_46379.33333333333333576.0Zinc fingerC2H2-type 7
TgeneZNF674chrX:44733233chrX:46360767ENST0000041438735469_49179.33333333333333576.0Zinc fingerC2H2-type 8
TgeneZNF674chrX:44733233chrX:46360767ENST0000041438735497_51979.33333333333333576.0Zinc fingerC2H2-type 9
TgeneZNF674chrX:44733233chrX:46360767ENST0000041438735525_54779.33333333333333576.0Zinc fingerC2H2-type 10
TgeneZNF674chrX:44733233chrX:46360767ENST0000041438735553_57579.33333333333333576.0Zinc fingerC2H2-type 11
TgeneZNF674chrX:44733233chrX:46360767ENST0000052337446224_24684.33333333333333582.0Zinc fingerC2H2-type 1
TgeneZNF674chrX:44733233chrX:46360767ENST0000052337446252_27484.33333333333333582.0Zinc fingerC2H2-type 2
TgeneZNF674chrX:44733233chrX:46360767ENST0000052337446280_30284.33333333333333582.0Zinc fingerC2H2-type 3
TgeneZNF674chrX:44733233chrX:46360767ENST0000052337446308_33084.33333333333333582.0Zinc fingerC2H2-type 4
TgeneZNF674chrX:44733233chrX:46360767ENST0000052337446385_40784.33333333333333582.0Zinc fingerC2H2-type 5
TgeneZNF674chrX:44733233chrX:46360767ENST0000052337446413_43584.33333333333333582.0Zinc fingerC2H2-type 6
TgeneZNF674chrX:44733233chrX:46360767ENST0000052337446441_46384.33333333333333582.0Zinc fingerC2H2-type 7
TgeneZNF674chrX:44733233chrX:46360767ENST0000052337446469_49184.33333333333333582.0Zinc fingerC2H2-type 8
TgeneZNF674chrX:44733233chrX:46360767ENST0000052337446497_51984.33333333333333582.0Zinc fingerC2H2-type 9
TgeneZNF674chrX:44733233chrX:46360767ENST0000052337446525_54784.33333333333333582.0Zinc fingerC2H2-type 10
TgeneZNF674chrX:44733233chrX:46360767ENST0000052337446553_57584.33333333333333582.0Zinc fingerC2H2-type 11
TgeneZNF674chrX:44733233chrX:46360770ENST0000041438735224_24679.33333333333333576.0Zinc fingerC2H2-type 1
TgeneZNF674chrX:44733233chrX:46360770ENST0000041438735252_27479.33333333333333576.0Zinc fingerC2H2-type 2
TgeneZNF674chrX:44733233chrX:46360770ENST0000041438735280_30279.33333333333333576.0Zinc fingerC2H2-type 3
TgeneZNF674chrX:44733233chrX:46360770ENST0000041438735308_33079.33333333333333576.0Zinc fingerC2H2-type 4
TgeneZNF674chrX:44733233chrX:46360770ENST0000041438735385_40779.33333333333333576.0Zinc fingerC2H2-type 5
TgeneZNF674chrX:44733233chrX:46360770ENST0000041438735413_43579.33333333333333576.0Zinc fingerC2H2-type 6
TgeneZNF674chrX:44733233chrX:46360770ENST0000041438735441_46379.33333333333333576.0Zinc fingerC2H2-type 7
TgeneZNF674chrX:44733233chrX:46360770ENST0000041438735469_49179.33333333333333576.0Zinc fingerC2H2-type 8
TgeneZNF674chrX:44733233chrX:46360770ENST0000041438735497_51979.33333333333333576.0Zinc fingerC2H2-type 9
TgeneZNF674chrX:44733233chrX:46360770ENST0000041438735525_54779.33333333333333576.0Zinc fingerC2H2-type 10
TgeneZNF674chrX:44733233chrX:46360770ENST0000041438735553_57579.33333333333333576.0Zinc fingerC2H2-type 11
TgeneZNF674chrX:44733233chrX:46360770ENST0000052337446224_24684.33333333333333582.0Zinc fingerC2H2-type 1
TgeneZNF674chrX:44733233chrX:46360770ENST0000052337446252_27484.33333333333333582.0Zinc fingerC2H2-type 2
TgeneZNF674chrX:44733233chrX:46360770ENST0000052337446280_30284.33333333333333582.0Zinc fingerC2H2-type 3
TgeneZNF674chrX:44733233chrX:46360770ENST0000052337446308_33084.33333333333333582.0Zinc fingerC2H2-type 4
TgeneZNF674chrX:44733233chrX:46360770ENST0000052337446385_40784.33333333333333582.0Zinc fingerC2H2-type 5
TgeneZNF674chrX:44733233chrX:46360770ENST0000052337446413_43584.33333333333333582.0Zinc fingerC2H2-type 6
TgeneZNF674chrX:44733233chrX:46360770ENST0000052337446441_46384.33333333333333582.0Zinc fingerC2H2-type 7
TgeneZNF674chrX:44733233chrX:46360770ENST0000052337446469_49184.33333333333333582.0Zinc fingerC2H2-type 8
TgeneZNF674chrX:44733233chrX:46360770ENST0000052337446497_51984.33333333333333582.0Zinc fingerC2H2-type 9
TgeneZNF674chrX:44733233chrX:46360770ENST0000052337446525_54784.33333333333333582.0Zinc fingerC2H2-type 10
TgeneZNF674chrX:44733233chrX:46360770ENST0000052337446553_57584.33333333333333582.0Zinc fingerC2H2-type 11

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM6AchrX:44733233chrX:46360767ENST00000377967+2291095_125875.01402.0DomainJmjC
HgeneKDM6AchrX:44733233chrX:46360770ENST00000377967+2291095_125875.01402.0DomainJmjC
HgeneKDM6AchrX:44733233chrX:46360767ENST00000377967+229130_16375.01402.0RepeatNote=TPR 2
HgeneKDM6AchrX:44733233chrX:46360767ENST00000377967+229170_19975.01402.0RepeatNote=TPR 3
HgeneKDM6AchrX:44733233chrX:46360767ENST00000377967+229205_23875.01402.0RepeatNote=TPR 4
HgeneKDM6AchrX:44733233chrX:46360767ENST00000377967+229250_28375.01402.0RepeatNote=TPR 5
HgeneKDM6AchrX:44733233chrX:46360767ENST00000377967+229284_31775.01402.0RepeatNote=TPR 6
HgeneKDM6AchrX:44733233chrX:46360767ENST00000377967+229318_35175.01402.0RepeatNote=TPR 7
HgeneKDM6AchrX:44733233chrX:46360767ENST00000377967+229352_38575.01402.0RepeatNote=TPR 8
HgeneKDM6AchrX:44733233chrX:46360767ENST00000377967+22993_12675.01402.0RepeatNote=TPR 1
HgeneKDM6AchrX:44733233chrX:46360770ENST00000377967+229130_16375.01402.0RepeatNote=TPR 2
HgeneKDM6AchrX:44733233chrX:46360770ENST00000377967+229170_19975.01402.0RepeatNote=TPR 3
HgeneKDM6AchrX:44733233chrX:46360770ENST00000377967+229205_23875.01402.0RepeatNote=TPR 4
HgeneKDM6AchrX:44733233chrX:46360770ENST00000377967+229250_28375.01402.0RepeatNote=TPR 5
HgeneKDM6AchrX:44733233chrX:46360770ENST00000377967+229284_31775.01402.0RepeatNote=TPR 6
HgeneKDM6AchrX:44733233chrX:46360770ENST00000377967+229318_35175.01402.0RepeatNote=TPR 7
HgeneKDM6AchrX:44733233chrX:46360770ENST00000377967+229352_38575.01402.0RepeatNote=TPR 8
HgeneKDM6AchrX:44733233chrX:46360770ENST00000377967+22993_12675.01402.0RepeatNote=TPR 1
TgeneZNF674chrX:44733233chrX:46360767ENST00000414387358_7979.33333333333333576.0DomainKRAB
TgeneZNF674chrX:44733233chrX:46360767ENST00000523374468_7984.33333333333333582.0DomainKRAB
TgeneZNF674chrX:44733233chrX:46360770ENST00000414387358_7979.33333333333333576.0DomainKRAB
TgeneZNF674chrX:44733233chrX:46360770ENST00000523374468_7984.33333333333333582.0DomainKRAB


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KDM6A
ZNF674


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneKDM6AchrX:44733233chrX:46360767ENST00000377967+2291_109575.01402.0SUPT6H
HgeneKDM6AchrX:44733233chrX:46360770ENST00000377967+2291_109575.01402.0SUPT6H


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Related Drugs to KDM6A-ZNF674


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KDM6A-ZNF674


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource