UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:KIAA1199-ZYX

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KIAA1199-ZYX
FusionPDB ID: 42254
FusionGDB2.0 ID: 42254
HgeneTgene
Gene symbol

KIAA1199

ZYX

Gene ID

57214

7791

Gene namecell migration inducing hyaluronidase 1zyxin
SynonymsCCSP1|HYBID|KIAA1199|TMEM2LESP-2|HED-2
Cytomap

15q25.1

7q34

Type of geneprotein-codingprotein-coding
Descriptioncell migration-inducing and hyaluronan-binding proteincell migration inducing hyaluronan binding proteincell migration inducing protein, hyaluronan bindingcolon cancer secreted protein 1hyaluronan-binding protein involved in hyaluronan depolymerizatiozyxinzyxin-2
Modification date2020031320200327
UniProtAcc.

ZYX

Ensembl transtripts involved in fusion geneENST idsENST00000220244, ENST00000356249, 
ENST00000394685, 		ENST00000322764, 
ENST00000392910, ENST00000449423, 
ENST00000477373, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score5 X 4 X 4=8011 X 15 X 5=825
# samples 614
** MAII scorelog2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/825*10)=-2.55896729218821
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: KIAA1199 [Title/Abstract] AND ZYX [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KIAA1199(81224380)-ZYX(143085312), # samples:1
KIAA1199(81224380)-ZYX(143078653), # samples:1
KIAA1199(81224380)-ZYX(143078650), # samples:1
Anticipated loss of major functional domain due to fusion event.KIAA1199-ZYX seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KIAA1199-ZYX seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KIAA1199-ZYX seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KIAA1199-ZYX seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKIAA1199

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

23990668

HgeneKIAA1199

GO:0030335

positive regulation of cell migration

23990668

HgeneKIAA1199

GO:0051281

positive regulation of release of sequestered calcium ion into cytosol

23990668

HgeneKIAA1199

GO:0090314

positive regulation of protein targeting to membrane

23990668

HgeneKIAA1199

GO:1900020

positive regulation of protein kinase C activity

23990668


check buttonFusion gene breakpoints across KIAA1199 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZYX (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-76-4926-01BKIAA1199chr15

81224380

+ZYXchr7

143078650

+
ChimerDB4GBMTCGA-76-4926-01BKIAA1199chr15

81224380

+ZYXchr7

143078653

+
ChimerDB4GBMTCGA-76-4926-01BKIAA1199chr15

81224380

+ZYXchr7

143085312

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000220244KIAA1199chr1581224380+ENST00000322764ZYXchr7143085312+4206308116237761204
ENST00000220244KIAA1199chr1581224380+ENST00000449423ZYXchr7143085312+4204308116237761204
ENST00000220244KIAA1199chr1581224380+ENST00000392910ZYXchr7143085312+4204308116237761204
ENST00000356249KIAA1199chr1581224380+ENST00000322764ZYXchr7143085312+4277315213438471237
ENST00000356249KIAA1199chr1581224380+ENST00000449423ZYXchr7143085312+4275315213438471237
ENST00000356249KIAA1199chr1581224380+ENST00000392910ZYXchr7143085312+4275315213438471237
ENST00000394685KIAA1199chr1581224380+ENST00000322764ZYXchr7143085312+4337321236839071179
ENST00000394685KIAA1199chr1581224380+ENST00000449423ZYXchr7143085312+4335321236839071179
ENST00000394685KIAA1199chr1581224380+ENST00000392910ZYXchr7143085312+4335321236839071179

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000220244ENST00000322764KIAA1199chr1581224380+ZYXchr7143085312+0.0015894860.99841046
ENST00000220244ENST00000449423KIAA1199chr1581224380+ZYXchr7143085312+0.0015824460.9984175
ENST00000220244ENST00000392910KIAA1199chr1581224380+ZYXchr7143085312+0.0015824460.9984175
ENST00000356249ENST00000322764KIAA1199chr1581224380+ZYXchr7143085312+0.0018014630.99819857
ENST00000356249ENST00000449423KIAA1199chr1581224380+ZYXchr7143085312+0.0017937040.99820626
ENST00000356249ENST00000392910KIAA1199chr1581224380+ZYXchr7143085312+0.0017937040.99820626
ENST00000394685ENST00000322764KIAA1199chr1581224380+ZYXchr7143085312+0.0019466790.9980533
ENST00000394685ENST00000449423KIAA1199chr1581224380+ZYXchr7143085312+0.0019384280.9980616
ENST00000394685ENST00000392910KIAA1199chr1581224380+ZYXchr7143085312+0.0019384280.9980616

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>42254_42254_1_KIAA1199-ZYX_KIAA1199_chr15_81224380_ENST00000220244_ZYX_chr7_143085312_ENST00000322764_length(amino acids)=1204AA_BP=973
MPTPRELAAPGGQRPDVRGRCAPGPRGVTLSRLQTQREHTARMGAAGRQDFLFKAMLTISWLTLTCFPGATSTVAAGCPDQSPELQPWNP
GHDQDHHVHIGQGKTLLLTSSATVYSIHISEGGKLVIKDHDEPIVLRTRHILIDNGGELHAGSALCPFQGNFTIILYGRADEGIQPDPYY
GLKYIGVGKGGALELHGQKKLSWTFLNKTLHPGGMAEGGYFFERSWGHRGVIVHVIDPKSGTVIHSDRFDTYRSKKESERLVQYLNAVPD
GRILSVAVNDEGSRNLDDMARKAMTKLGSKHFLHLGFRHPWSFLTVKGNPSSSVEDHIEYHGHRGSAAARVFKLFQTEHGEYFNVSLSSE
WVQDVEWTEWFDHDKVSQTKGGEKISDLWKAHPGKICNRPIDIQATTMDGVNLSTEVVYKKGQDYRFACYDRGRACRSYRVRFLCGKPVR
PKLTVTIDTNVNSTILNLEDNVQSWKPGDTLVIASTDYSMYQAEEFQVLPCRSCAPNQVKVAGKPMYLHIGEEIDGVDMRAEVGLLSRNI
IVMGEMEDKCYPYRNHICNFFDFDTFGGHIKFALGFKAAHLEGTELKHMGQQLVGQYPIHFHLAGDVDERGGYDPPTYIRDLSIHHTFSR
CVTVHGSNGLLIKDVVGYNSLGHCFFTEDGPEERNTFDHCLGLLVKSGTLLPSDRDSKMCKMITEDSYPGYIPKPRQDCNAVSTFWMANP
NNNLINCAAAGSEETGFWFIFHHVPTGPSVGMYSPGYSEHIPLGKFYNNRAHSNYRAGMIIDNGVKTTEASAKDKRPFLSIISARYSPHQ
DADPLKPREPAIIRHFIAYKNQDHGAWLRGGDVWLDSCRFADNGIGLTLASGGTFPYDDGSKQEIKNSLFVGESGNVGTEMMDNRIWGPG
GLDHSGRTLPIGQNFPIRGIQLYDGPINIQNCTFRKFVALEGRHTSALAFRLNNAWQSCPHNNVTGIAFEDVPVRSPGAPGPLTLKEVEE
LEQLTQQLMQDMEHPQRQNVAVNELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLEKCNTCG
EPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCE

--------------------------------------------------------------

>42254_42254_2_KIAA1199-ZYX_KIAA1199_chr15_81224380_ENST00000220244_ZYX_chr7_143085312_ENST00000392910_length(amino acids)=1204AA_BP=973
MPTPRELAAPGGQRPDVRGRCAPGPRGVTLSRLQTQREHTARMGAAGRQDFLFKAMLTISWLTLTCFPGATSTVAAGCPDQSPELQPWNP
GHDQDHHVHIGQGKTLLLTSSATVYSIHISEGGKLVIKDHDEPIVLRTRHILIDNGGELHAGSALCPFQGNFTIILYGRADEGIQPDPYY
GLKYIGVGKGGALELHGQKKLSWTFLNKTLHPGGMAEGGYFFERSWGHRGVIVHVIDPKSGTVIHSDRFDTYRSKKESERLVQYLNAVPD
GRILSVAVNDEGSRNLDDMARKAMTKLGSKHFLHLGFRHPWSFLTVKGNPSSSVEDHIEYHGHRGSAAARVFKLFQTEHGEYFNVSLSSE
WVQDVEWTEWFDHDKVSQTKGGEKISDLWKAHPGKICNRPIDIQATTMDGVNLSTEVVYKKGQDYRFACYDRGRACRSYRVRFLCGKPVR
PKLTVTIDTNVNSTILNLEDNVQSWKPGDTLVIASTDYSMYQAEEFQVLPCRSCAPNQVKVAGKPMYLHIGEEIDGVDMRAEVGLLSRNI
IVMGEMEDKCYPYRNHICNFFDFDTFGGHIKFALGFKAAHLEGTELKHMGQQLVGQYPIHFHLAGDVDERGGYDPPTYIRDLSIHHTFSR
CVTVHGSNGLLIKDVVGYNSLGHCFFTEDGPEERNTFDHCLGLLVKSGTLLPSDRDSKMCKMITEDSYPGYIPKPRQDCNAVSTFWMANP
NNNLINCAAAGSEETGFWFIFHHVPTGPSVGMYSPGYSEHIPLGKFYNNRAHSNYRAGMIIDNGVKTTEASAKDKRPFLSIISARYSPHQ
DADPLKPREPAIIRHFIAYKNQDHGAWLRGGDVWLDSCRFADNGIGLTLASGGTFPYDDGSKQEIKNSLFVGESGNVGTEMMDNRIWGPG
GLDHSGRTLPIGQNFPIRGIQLYDGPINIQNCTFRKFVALEGRHTSALAFRLNNAWQSCPHNNVTGIAFEDVPVRSPGAPGPLTLKEVEE
LEQLTQQLMQDMEHPQRQNVAVNELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLEKCNTCG
EPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCE

--------------------------------------------------------------

>42254_42254_3_KIAA1199-ZYX_KIAA1199_chr15_81224380_ENST00000220244_ZYX_chr7_143085312_ENST00000449423_length(amino acids)=1204AA_BP=973
MPTPRELAAPGGQRPDVRGRCAPGPRGVTLSRLQTQREHTARMGAAGRQDFLFKAMLTISWLTLTCFPGATSTVAAGCPDQSPELQPWNP
GHDQDHHVHIGQGKTLLLTSSATVYSIHISEGGKLVIKDHDEPIVLRTRHILIDNGGELHAGSALCPFQGNFTIILYGRADEGIQPDPYY
GLKYIGVGKGGALELHGQKKLSWTFLNKTLHPGGMAEGGYFFERSWGHRGVIVHVIDPKSGTVIHSDRFDTYRSKKESERLVQYLNAVPD
GRILSVAVNDEGSRNLDDMARKAMTKLGSKHFLHLGFRHPWSFLTVKGNPSSSVEDHIEYHGHRGSAAARVFKLFQTEHGEYFNVSLSSE
WVQDVEWTEWFDHDKVSQTKGGEKISDLWKAHPGKICNRPIDIQATTMDGVNLSTEVVYKKGQDYRFACYDRGRACRSYRVRFLCGKPVR
PKLTVTIDTNVNSTILNLEDNVQSWKPGDTLVIASTDYSMYQAEEFQVLPCRSCAPNQVKVAGKPMYLHIGEEIDGVDMRAEVGLLSRNI
IVMGEMEDKCYPYRNHICNFFDFDTFGGHIKFALGFKAAHLEGTELKHMGQQLVGQYPIHFHLAGDVDERGGYDPPTYIRDLSIHHTFSR
CVTVHGSNGLLIKDVVGYNSLGHCFFTEDGPEERNTFDHCLGLLVKSGTLLPSDRDSKMCKMITEDSYPGYIPKPRQDCNAVSTFWMANP
NNNLINCAAAGSEETGFWFIFHHVPTGPSVGMYSPGYSEHIPLGKFYNNRAHSNYRAGMIIDNGVKTTEASAKDKRPFLSIISARYSPHQ
DADPLKPREPAIIRHFIAYKNQDHGAWLRGGDVWLDSCRFADNGIGLTLASGGTFPYDDGSKQEIKNSLFVGESGNVGTEMMDNRIWGPG
GLDHSGRTLPIGQNFPIRGIQLYDGPINIQNCTFRKFVALEGRHTSALAFRLNNAWQSCPHNNVTGIAFEDVPVRSPGAPGPLTLKEVEE
LEQLTQQLMQDMEHPQRQNVAVNELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLEKCNTCG
EPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCE

--------------------------------------------------------------

>42254_42254_4_KIAA1199-ZYX_KIAA1199_chr15_81224380_ENST00000356249_ZYX_chr7_143085312_ENST00000322764_length(amino acids)=1237AA_BP=1006
MPTPRELAAPGGQRPDVRGRCAPGPRGVTLSRLQTQREKLHSGGEGVLSAKDEIPPITRSLSCRTQAGQREHTARMGAAGRQDFLFKAML
TISWLTLTCFPGATSTVAAGCPDQSPELQPWNPGHDQDHHVHIGQGKTLLLTSSATVYSIHISEGGKLVIKDHDEPIVLRTRHILIDNGG
ELHAGSALCPFQGNFTIILYGRADEGIQPDPYYGLKYIGVGKGGALELHGQKKLSWTFLNKTLHPGGMAEGGYFFERSWGHRGVIVHVID
PKSGTVIHSDRFDTYRSKKESERLVQYLNAVPDGRILSVAVNDEGSRNLDDMARKAMTKLGSKHFLHLGFRHPWSFLTVKGNPSSSVEDH
IEYHGHRGSAAARVFKLFQTEHGEYFNVSLSSEWVQDVEWTEWFDHDKVSQTKGGEKISDLWKAHPGKICNRPIDIQATTMDGVNLSTEV
VYKKGQDYRFACYDRGRACRSYRVRFLCGKPVRPKLTVTIDTNVNSTILNLEDNVQSWKPGDTLVIASTDYSMYQAEEFQVLPCRSCAPN
QVKVAGKPMYLHIGEEIDGVDMRAEVGLLSRNIIVMGEMEDKCYPYRNHICNFFDFDTFGGHIKFALGFKAAHLEGTELKHMGQQLVGQY
PIHFHLAGDVDERGGYDPPTYIRDLSIHHTFSRCVTVHGSNGLLIKDVVGYNSLGHCFFTEDGPEERNTFDHCLGLLVKSGTLLPSDRDS
KMCKMITEDSYPGYIPKPRQDCNAVSTFWMANPNNNLINCAAAGSEETGFWFIFHHVPTGPSVGMYSPGYSEHIPLGKFYNNRAHSNYRA
GMIIDNGVKTTEASAKDKRPFLSIISARYSPHQDADPLKPREPAIIRHFIAYKNQDHGAWLRGGDVWLDSCRFADNGIGLTLASGGTFPY
DDGSKQEIKNSLFVGESGNVGTEMMDNRIWGPGGLDHSGRTLPIGQNFPIRGIQLYDGPINIQNCTFRKFVALEGRHTSALAFRLNNAWQ
SCPHNNVTGIAFEDVPVRSPGAPGPLTLKEVEELEQLTQQLMQDMEHPQRQNVAVNELCGRCHQPLARAQPAVRALGQLFHIACFTCHQC
AQQLQGQQFYSLEGAPYCEGCYTDTLEKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCS

--------------------------------------------------------------

>42254_42254_5_KIAA1199-ZYX_KIAA1199_chr15_81224380_ENST00000356249_ZYX_chr7_143085312_ENST00000392910_length(amino acids)=1237AA_BP=1006
MPTPRELAAPGGQRPDVRGRCAPGPRGVTLSRLQTQREKLHSGGEGVLSAKDEIPPITRSLSCRTQAGQREHTARMGAAGRQDFLFKAML
TISWLTLTCFPGATSTVAAGCPDQSPELQPWNPGHDQDHHVHIGQGKTLLLTSSATVYSIHISEGGKLVIKDHDEPIVLRTRHILIDNGG
ELHAGSALCPFQGNFTIILYGRADEGIQPDPYYGLKYIGVGKGGALELHGQKKLSWTFLNKTLHPGGMAEGGYFFERSWGHRGVIVHVID
PKSGTVIHSDRFDTYRSKKESERLVQYLNAVPDGRILSVAVNDEGSRNLDDMARKAMTKLGSKHFLHLGFRHPWSFLTVKGNPSSSVEDH
IEYHGHRGSAAARVFKLFQTEHGEYFNVSLSSEWVQDVEWTEWFDHDKVSQTKGGEKISDLWKAHPGKICNRPIDIQATTMDGVNLSTEV
VYKKGQDYRFACYDRGRACRSYRVRFLCGKPVRPKLTVTIDTNVNSTILNLEDNVQSWKPGDTLVIASTDYSMYQAEEFQVLPCRSCAPN
QVKVAGKPMYLHIGEEIDGVDMRAEVGLLSRNIIVMGEMEDKCYPYRNHICNFFDFDTFGGHIKFALGFKAAHLEGTELKHMGQQLVGQY
PIHFHLAGDVDERGGYDPPTYIRDLSIHHTFSRCVTVHGSNGLLIKDVVGYNSLGHCFFTEDGPEERNTFDHCLGLLVKSGTLLPSDRDS
KMCKMITEDSYPGYIPKPRQDCNAVSTFWMANPNNNLINCAAAGSEETGFWFIFHHVPTGPSVGMYSPGYSEHIPLGKFYNNRAHSNYRA
GMIIDNGVKTTEASAKDKRPFLSIISARYSPHQDADPLKPREPAIIRHFIAYKNQDHGAWLRGGDVWLDSCRFADNGIGLTLASGGTFPY
DDGSKQEIKNSLFVGESGNVGTEMMDNRIWGPGGLDHSGRTLPIGQNFPIRGIQLYDGPINIQNCTFRKFVALEGRHTSALAFRLNNAWQ
SCPHNNVTGIAFEDVPVRSPGAPGPLTLKEVEELEQLTQQLMQDMEHPQRQNVAVNELCGRCHQPLARAQPAVRALGQLFHIACFTCHQC
AQQLQGQQFYSLEGAPYCEGCYTDTLEKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCS

--------------------------------------------------------------

>42254_42254_6_KIAA1199-ZYX_KIAA1199_chr15_81224380_ENST00000356249_ZYX_chr7_143085312_ENST00000449423_length(amino acids)=1237AA_BP=1006
MPTPRELAAPGGQRPDVRGRCAPGPRGVTLSRLQTQREKLHSGGEGVLSAKDEIPPITRSLSCRTQAGQREHTARMGAAGRQDFLFKAML
TISWLTLTCFPGATSTVAAGCPDQSPELQPWNPGHDQDHHVHIGQGKTLLLTSSATVYSIHISEGGKLVIKDHDEPIVLRTRHILIDNGG
ELHAGSALCPFQGNFTIILYGRADEGIQPDPYYGLKYIGVGKGGALELHGQKKLSWTFLNKTLHPGGMAEGGYFFERSWGHRGVIVHVID
PKSGTVIHSDRFDTYRSKKESERLVQYLNAVPDGRILSVAVNDEGSRNLDDMARKAMTKLGSKHFLHLGFRHPWSFLTVKGNPSSSVEDH
IEYHGHRGSAAARVFKLFQTEHGEYFNVSLSSEWVQDVEWTEWFDHDKVSQTKGGEKISDLWKAHPGKICNRPIDIQATTMDGVNLSTEV
VYKKGQDYRFACYDRGRACRSYRVRFLCGKPVRPKLTVTIDTNVNSTILNLEDNVQSWKPGDTLVIASTDYSMYQAEEFQVLPCRSCAPN
QVKVAGKPMYLHIGEEIDGVDMRAEVGLLSRNIIVMGEMEDKCYPYRNHICNFFDFDTFGGHIKFALGFKAAHLEGTELKHMGQQLVGQY
PIHFHLAGDVDERGGYDPPTYIRDLSIHHTFSRCVTVHGSNGLLIKDVVGYNSLGHCFFTEDGPEERNTFDHCLGLLVKSGTLLPSDRDS
KMCKMITEDSYPGYIPKPRQDCNAVSTFWMANPNNNLINCAAAGSEETGFWFIFHHVPTGPSVGMYSPGYSEHIPLGKFYNNRAHSNYRA
GMIIDNGVKTTEASAKDKRPFLSIISARYSPHQDADPLKPREPAIIRHFIAYKNQDHGAWLRGGDVWLDSCRFADNGIGLTLASGGTFPY
DDGSKQEIKNSLFVGESGNVGTEMMDNRIWGPGGLDHSGRTLPIGQNFPIRGIQLYDGPINIQNCTFRKFVALEGRHTSALAFRLNNAWQ
SCPHNNVTGIAFEDVPVRSPGAPGPLTLKEVEELEQLTQQLMQDMEHPQRQNVAVNELCGRCHQPLARAQPAVRALGQLFHIACFTCHQC
AQQLQGQQFYSLEGAPYCEGCYTDTLEKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCS

--------------------------------------------------------------

>42254_42254_7_KIAA1199-ZYX_KIAA1199_chr15_81224380_ENST00000394685_ZYX_chr7_143085312_ENST00000322764_length(amino acids)=1179AA_BP=948
MALSCGSWGSHWEHTARMGAAGRQDFLFKAMLTISWLTLTCFPGATSTVAAGCPDQSPELQPWNPGHDQDHHVHIGQGKTLLLTSSATVY
SIHISEGGKLVIKDHDEPIVLRTRHILIDNGGELHAGSALCPFQGNFTIILYGRADEGIQPDPYYGLKYIGVGKGGALELHGQKKLSWTF
LNKTLHPGGMAEGGYFFERSWGHRGVIVHVIDPKSGTVIHSDRFDTYRSKKESERLVQYLNAVPDGRILSVAVNDEGSRNLDDMARKAMT
KLGSKHFLHLGFRHPWSFLTVKGNPSSSVEDHIEYHGHRGSAAARVFKLFQTEHGEYFNVSLSSEWVQDVEWTEWFDHDKVSQTKGGEKI
SDLWKAHPGKICNRPIDIQATTMDGVNLSTEVVYKKGQDYRFACYDRGRACRSYRVRFLCGKPVRPKLTVTIDTNVNSTILNLEDNVQSW
KPGDTLVIASTDYSMYQAEEFQVLPCRSCAPNQVKVAGKPMYLHIGEEIDGVDMRAEVGLLSRNIIVMGEMEDKCYPYRNHICNFFDFDT
FGGHIKFALGFKAAHLEGTELKHMGQQLVGQYPIHFHLAGDVDERGGYDPPTYIRDLSIHHTFSRCVTVHGSNGLLIKDVVGYNSLGHCF
FTEDGPEERNTFDHCLGLLVKSGTLLPSDRDSKMCKMITEDSYPGYIPKPRQDCNAVSTFWMANPNNNLINCAAAGSEETGFWFIFHHVP
TGPSVGMYSPGYSEHIPLGKFYNNRAHSNYRAGMIIDNGVKTTEASAKDKRPFLSIISARYSPHQDADPLKPREPAIIRHFIAYKNQDHG
AWLRGGDVWLDSCRFADNGIGLTLASGGTFPYDDGSKQEIKNSLFVGESGNVGTEMMDNRIWGPGGLDHSGRTLPIGQNFPIRGIQLYDG
PINIQNCTFRKFVALEGRHTSALAFRLNNAWQSCPHNNVTGIAFEDVPVRSPGAPGPLTLKEVEELEQLTQQLMQDMEHPQRQNVAVNEL
CGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLEKCNTCGEPITDRMLRATGKAYHPHCFTCVVC
ARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLCR

--------------------------------------------------------------

>42254_42254_8_KIAA1199-ZYX_KIAA1199_chr15_81224380_ENST00000394685_ZYX_chr7_143085312_ENST00000392910_length(amino acids)=1179AA_BP=948
MALSCGSWGSHWEHTARMGAAGRQDFLFKAMLTISWLTLTCFPGATSTVAAGCPDQSPELQPWNPGHDQDHHVHIGQGKTLLLTSSATVY
SIHISEGGKLVIKDHDEPIVLRTRHILIDNGGELHAGSALCPFQGNFTIILYGRADEGIQPDPYYGLKYIGVGKGGALELHGQKKLSWTF
LNKTLHPGGMAEGGYFFERSWGHRGVIVHVIDPKSGTVIHSDRFDTYRSKKESERLVQYLNAVPDGRILSVAVNDEGSRNLDDMARKAMT
KLGSKHFLHLGFRHPWSFLTVKGNPSSSVEDHIEYHGHRGSAAARVFKLFQTEHGEYFNVSLSSEWVQDVEWTEWFDHDKVSQTKGGEKI
SDLWKAHPGKICNRPIDIQATTMDGVNLSTEVVYKKGQDYRFACYDRGRACRSYRVRFLCGKPVRPKLTVTIDTNVNSTILNLEDNVQSW
KPGDTLVIASTDYSMYQAEEFQVLPCRSCAPNQVKVAGKPMYLHIGEEIDGVDMRAEVGLLSRNIIVMGEMEDKCYPYRNHICNFFDFDT
FGGHIKFALGFKAAHLEGTELKHMGQQLVGQYPIHFHLAGDVDERGGYDPPTYIRDLSIHHTFSRCVTVHGSNGLLIKDVVGYNSLGHCF
FTEDGPEERNTFDHCLGLLVKSGTLLPSDRDSKMCKMITEDSYPGYIPKPRQDCNAVSTFWMANPNNNLINCAAAGSEETGFWFIFHHVP
TGPSVGMYSPGYSEHIPLGKFYNNRAHSNYRAGMIIDNGVKTTEASAKDKRPFLSIISARYSPHQDADPLKPREPAIIRHFIAYKNQDHG
AWLRGGDVWLDSCRFADNGIGLTLASGGTFPYDDGSKQEIKNSLFVGESGNVGTEMMDNRIWGPGGLDHSGRTLPIGQNFPIRGIQLYDG
PINIQNCTFRKFVALEGRHTSALAFRLNNAWQSCPHNNVTGIAFEDVPVRSPGAPGPLTLKEVEELEQLTQQLMQDMEHPQRQNVAVNEL
CGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLEKCNTCGEPITDRMLRATGKAYHPHCFTCVVC
ARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLCR

--------------------------------------------------------------

>42254_42254_9_KIAA1199-ZYX_KIAA1199_chr15_81224380_ENST00000394685_ZYX_chr7_143085312_ENST00000449423_length(amino acids)=1179AA_BP=948
MALSCGSWGSHWEHTARMGAAGRQDFLFKAMLTISWLTLTCFPGATSTVAAGCPDQSPELQPWNPGHDQDHHVHIGQGKTLLLTSSATVY
SIHISEGGKLVIKDHDEPIVLRTRHILIDNGGELHAGSALCPFQGNFTIILYGRADEGIQPDPYYGLKYIGVGKGGALELHGQKKLSWTF
LNKTLHPGGMAEGGYFFERSWGHRGVIVHVIDPKSGTVIHSDRFDTYRSKKESERLVQYLNAVPDGRILSVAVNDEGSRNLDDMARKAMT
KLGSKHFLHLGFRHPWSFLTVKGNPSSSVEDHIEYHGHRGSAAARVFKLFQTEHGEYFNVSLSSEWVQDVEWTEWFDHDKVSQTKGGEKI
SDLWKAHPGKICNRPIDIQATTMDGVNLSTEVVYKKGQDYRFACYDRGRACRSYRVRFLCGKPVRPKLTVTIDTNVNSTILNLEDNVQSW
KPGDTLVIASTDYSMYQAEEFQVLPCRSCAPNQVKVAGKPMYLHIGEEIDGVDMRAEVGLLSRNIIVMGEMEDKCYPYRNHICNFFDFDT
FGGHIKFALGFKAAHLEGTELKHMGQQLVGQYPIHFHLAGDVDERGGYDPPTYIRDLSIHHTFSRCVTVHGSNGLLIKDVVGYNSLGHCF
FTEDGPEERNTFDHCLGLLVKSGTLLPSDRDSKMCKMITEDSYPGYIPKPRQDCNAVSTFWMANPNNNLINCAAAGSEETGFWFIFHHVP
TGPSVGMYSPGYSEHIPLGKFYNNRAHSNYRAGMIIDNGVKTTEASAKDKRPFLSIISARYSPHQDADPLKPREPAIIRHFIAYKNQDHG
AWLRGGDVWLDSCRFADNGIGLTLASGGTFPYDDGSKQEIKNSLFVGESGNVGTEMMDNRIWGPGGLDHSGRTLPIGQNFPIRGIQLYDG
PINIQNCTFRKFVALEGRHTSALAFRLNNAWQSCPHNNVTGIAFEDVPVRSPGAPGPLTLKEVEELEQLTQQLMQDMEHPQRQNVAVNEL
CGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLEKCNTCGEPITDRMLRATGKAYHPHCFTCVVC
ARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLCR

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:81224380/chr7:143085312)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ZYX

ZYX

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.572

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIAA1199chr15:81224380chr7:143085312ENST00000220244+212944_166931.01362.0DomainG8
HgeneKIAA1199chr15:81224380chr7:143085312ENST00000356249+223044_166931.01362.0DomainG8
HgeneKIAA1199chr15:81224380chr7:143085312ENST00000394685+223044_166931.01362.0DomainG8
HgeneKIAA1199chr15:81224380chr7:143085312ENST00000220244+2129572_594931.01362.0RepeatNote=PbH1 1
HgeneKIAA1199chr15:81224380chr7:143085312ENST00000220244+2129595_617931.01362.0RepeatNote=PbH1 2
HgeneKIAA1199chr15:81224380chr7:143085312ENST00000220244+2129719_741931.01362.0RepeatNote=PbH1 3
HgeneKIAA1199chr15:81224380chr7:143085312ENST00000220244+2129798_819931.01362.0RepeatNote=PbH1 4
HgeneKIAA1199chr15:81224380chr7:143085312ENST00000356249+2230572_594931.01362.0RepeatNote=PbH1 1
HgeneKIAA1199chr15:81224380chr7:143085312ENST00000356249+2230595_617931.01362.0RepeatNote=PbH1 2
HgeneKIAA1199chr15:81224380chr7:143085312ENST00000356249+2230719_741931.01362.0RepeatNote=PbH1 3
HgeneKIAA1199chr15:81224380chr7:143085312ENST00000356249+2230798_819931.01362.0RepeatNote=PbH1 4
HgeneKIAA1199chr15:81224380chr7:143085312ENST00000394685+2230572_594931.01362.0RepeatNote=PbH1 1
HgeneKIAA1199chr15:81224380chr7:143085312ENST00000394685+2230595_617931.01362.0RepeatNote=PbH1 2
HgeneKIAA1199chr15:81224380chr7:143085312ENST00000394685+2230719_741931.01362.0RepeatNote=PbH1 3
HgeneKIAA1199chr15:81224380chr7:143085312ENST00000394685+2230798_819931.01362.0RepeatNote=PbH1 4
TgeneZYXchr15:81224380chr7:143085312ENST00000322764410384_443341.0573.0DomainLIM zinc-binding 1
TgeneZYXchr15:81224380chr7:143085312ENST00000322764410444_503341.0573.0DomainLIM zinc-binding 2
TgeneZYXchr15:81224380chr7:143085312ENST00000322764410504_570341.0573.0DomainLIM zinc-binding 3

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZYXchr15:81224380chr7:143085312ENST00000322764410115_121341.0573.0Compositional biasNote=Pro-rich
TgeneZYXchr15:81224380chr7:143085312ENST00000322764410127_137341.0573.0Compositional biasNote=Pro-rich
TgeneZYXchr15:81224380chr7:143085312ENST0000032276441064_77341.0573.0Compositional biasNote=Pro-rich
TgeneZYXchr15:81224380chr7:143085312ENST0000032276441094_108341.0573.0Compositional biasNote=Pro-rich


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KIAA1199
ZYX


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to KIAA1199-ZYX


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to KIAA1199-ZYX


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource