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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:KIDINS220-KDM4C

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: KIDINS220-KDM4C
	FusionPDB ID: 42509
	FusionGDB2.0 ID: 42509
		Hgene	Tgene
	Gene symbol	KIDINS220	KDM4C
	Gene ID	57498	23081
	Gene name	kinase D interacting substrate 220	lysine demethylase 4C
	Synonyms	ARMS\|SINO	GASC1\|JHDM3C\|JMJD2C\|TDRD14C
	Cytomap	2p25.1	9p24.1
	Type of gene	protein-coding	protein-coding
	Description	kinase D-interacting substrate of 220 kDaankyrin repeat-rich membrane-spanning proteinkinase D-interacting substrate 220kDa	lysine-specific demethylase 4CJmjC domain-containing histone demethylation protein 3Cgene amplified in squamous cell carcinoma 1 proteinjumonji domain-containing protein 2Clysine (K)-specific demethylase 4Ctudor domain containing 14C
	Modification date	20200313	20200329
	UniProtAcc	Q9ULH0	Q9H3R0
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000256707, ENST00000319688, ENST00000418530, ENST00000427284, ENST00000473731, ENST00000436566,	ENST00000401787, ENST00000428870, ENST00000489243, ENST00000536108, ENST00000381306, ENST00000381309, ENST00000442236, ENST00000535193, ENST00000543771,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	13 X 11 X 9=1287	22 X 22 X 7=3388
	# samples	11	26
	** MAII score	log2(11/1287*10)=-3.54843662469604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(26/3388*10)=-3.70385034630374 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: KIDINS220 [Title/Abstract] AND KDM4C [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	KIDINS220(8918768)-KDM4C(7046861), # samples:1
Anticipated loss of major functional domain due to fusion event.	KIDINS220-KDM4C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KIDINS220-KDM4C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KIDINS220-KDM4C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KIDINS220-KDM4C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KIDINS220-KDM4C seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. KIDINS220-KDM4C seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. KIDINS220-KDM4C seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. KIDINS220-KDM4C seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	KDM4C	GO:0006357	regulation of transcription by RNA polymerase II	17277772
Tgene	KDM4C	GO:0033169	histone H3-K9 demethylation	18066052\|21914792
Tgene	KDM4C	GO:0070544	histone H3-K36 demethylation	21914792

Fusion gene breakpoints across KIDINS220 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KDM4C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-D7-A4YX	KIDINS220	chr2	8918768	-	KDM4C	chr9	7046861	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000256707	KIDINS220	chr2	8918768	-	ENST00000535193	KDM4C	chr9	7046861	+	3879	2885	164	3067	967
ENST00000256707	KIDINS220	chr2	8918768	-	ENST00000543771	KDM4C	chr9	7046861	+	3879	2885	164	3067	967
ENST00000256707	KIDINS220	chr2	8918768	-	ENST00000381306	KDM4C	chr9	7046861	+	4662	2885	164	3769	1201
ENST00000256707	KIDINS220	chr2	8918768	-	ENST00000381309	KDM4C	chr9	7046861	+	4716	2885	164	3796	1210
ENST00000256707	KIDINS220	chr2	8918768	-	ENST00000442236	KDM4C	chr9	7046861	+	3892	2885	164	3796	1210
ENST00000427284	KIDINS220	chr2	8918768	-	ENST00000535193	KDM4C	chr9	7046861	+	3879	2885	164	3067	967
ENST00000427284	KIDINS220	chr2	8918768	-	ENST00000543771	KDM4C	chr9	7046861	+	3879	2885	164	3067	967
ENST00000427284	KIDINS220	chr2	8918768	-	ENST00000381306	KDM4C	chr9	7046861	+	4662	2885	164	3769	1201
ENST00000427284	KIDINS220	chr2	8918768	-	ENST00000381309	KDM4C	chr9	7046861	+	4716	2885	164	3796	1210
ENST00000427284	KIDINS220	chr2	8918768	-	ENST00000442236	KDM4C	chr9	7046861	+	3892	2885	164	3796	1210
ENST00000319688	KIDINS220	chr2	8918768	-	ENST00000535193	KDM4C	chr9	7046861	+	3857	2863	139	3045	968
ENST00000319688	KIDINS220	chr2	8918768	-	ENST00000543771	KDM4C	chr9	7046861	+	3857	2863	139	3045	968
ENST00000319688	KIDINS220	chr2	8918768	-	ENST00000381306	KDM4C	chr9	7046861	+	4640	2863	139	3747	1202
ENST00000319688	KIDINS220	chr2	8918768	-	ENST00000381309	KDM4C	chr9	7046861	+	4694	2863	139	3774	1211
ENST00000319688	KIDINS220	chr2	8918768	-	ENST00000442236	KDM4C	chr9	7046861	+	3870	2863	139	3774	1211

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000256707	ENST00000535193	KIDINS220	chr2	8918768	-	KDM4C	chr9	7046861	+	0.000194817	0.99980515
ENST00000256707	ENST00000543771	KIDINS220	chr2	8918768	-	KDM4C	chr9	7046861	+	0.000194817	0.99980515
ENST00000256707	ENST00000381306	KIDINS220	chr2	8918768	-	KDM4C	chr9	7046861	+	0.000131516	0.9998685
ENST00000256707	ENST00000381309	KIDINS220	chr2	8918768	-	KDM4C	chr9	7046861	+	4.85E-05	0.9999515
ENST00000256707	ENST00000442236	KIDINS220	chr2	8918768	-	KDM4C	chr9	7046861	+	7.74E-05	0.99992263
ENST00000427284	ENST00000535193	KIDINS220	chr2	8918768	-	KDM4C	chr9	7046861	+	0.000194817	0.99980515
ENST00000427284	ENST00000543771	KIDINS220	chr2	8918768	-	KDM4C	chr9	7046861	+	0.000194817	0.99980515
ENST00000427284	ENST00000381306	KIDINS220	chr2	8918768	-	KDM4C	chr9	7046861	+	0.000131516	0.9998685
ENST00000427284	ENST00000381309	KIDINS220	chr2	8918768	-	KDM4C	chr9	7046861	+	4.85E-05	0.9999515
ENST00000427284	ENST00000442236	KIDINS220	chr2	8918768	-	KDM4C	chr9	7046861	+	7.74E-05	0.99992263
ENST00000319688	ENST00000535193	KIDINS220	chr2	8918768	-	KDM4C	chr9	7046861	+	0.000219504	0.9997805
ENST00000319688	ENST00000543771	KIDINS220	chr2	8918768	-	KDM4C	chr9	7046861	+	0.000219504	0.9997805
ENST00000319688	ENST00000381306	KIDINS220	chr2	8918768	-	KDM4C	chr9	7046861	+	0.00013284	0.9998672
ENST00000319688	ENST00000381309	KIDINS220	chr2	8918768	-	KDM4C	chr9	7046861	+	4.92E-05	0.99995077
ENST00000319688	ENST00000442236	KIDINS220	chr2	8918768	-	KDM4C	chr9	7046861	+	8.05E-05	0.99991953

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>42509_42509_1_KIDINS220-KDM4C_KIDINS220_chr2_8918768_ENST00000256707_KDM4C_chr9_7046861_ENST00000381306_length(amino acids)=1201AA_BP=907
MQLSVKMSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHV
HIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPL
VWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNI
PDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELL
LDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLGYDLYS
SALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPLFQFSWLIVFLTLLLCGGLGLLFAFTVHPNLGIAVSLSFLA
LLYIFFIVIYFGGRREGESWNWAWVLSTRLARHIGYLELLLKLMFVNPPELPEQTTKALPVRFLFTDYNRLSSVGGETSLAEMIATLSDA
CEREFGFLATRLFRVFKTEDTQGKKKWKKTCCLPSFVIFLFIIGCIISGITLLAIFRVDPKHLTVNAVLISIASVVGLAFVLNCRTWWQV
LDSLLNSQRKRLHNAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACEQDKVLQMLDTVRVLFSKGPFIAIF
ASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLSNARKFLVTSATNGDVPCSDTTGIQEDADRRVSQNSLGEMTKLGS
KTALNRRECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASF
HVTCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDDGSFSRDTFPEDI
VSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFVSAGRCHLGTCQVNSLSS

--------------------------------------------------------------

>42509_42509_2_KIDINS220-KDM4C_KIDINS220_chr2_8918768_ENST00000256707_KDM4C_chr9_7046861_ENST00000381309_length(amino acids)=1210AA_BP=907
MQLSVKMSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHV
HIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPL
VWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNI
PDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELL
LDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLGYDLYS
SALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPLFQFSWLIVFLTLLLCGGLGLLFAFTVHPNLGIAVSLSFLA
LLYIFFIVIYFGGRREGESWNWAWVLSTRLARHIGYLELLLKLMFVNPPELPEQTTKALPVRFLFTDYNRLSSVGGETSLAEMIATLSDA
CEREFGFLATRLFRVFKTEDTQGKKKWKKTCCLPSFVIFLFIIGCIISGITLLAIFRVDPKHLTVNAVLISIASVVGLAFVLNCRTWWQV
LDSLLNSQRKRLHNAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACEQDKVLQMLDTVRVLFSKGPFIAIF
ASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLSNARKFLVTSATNGDVPCSDTTGIQEDADRRVSQNSLGEMTKLGS
KTALNRRECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASF
HVTCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDDGSFSRDTFPEDI
VSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADII

--------------------------------------------------------------

>42509_42509_3_KIDINS220-KDM4C_KIDINS220_chr2_8918768_ENST00000256707_KDM4C_chr9_7046861_ENST00000442236_length(amino acids)=1210AA_BP=907
MQLSVKMSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHV
HIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPL
VWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNI
PDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELL
LDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLGYDLYS
SALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPLFQFSWLIVFLTLLLCGGLGLLFAFTVHPNLGIAVSLSFLA
LLYIFFIVIYFGGRREGESWNWAWVLSTRLARHIGYLELLLKLMFVNPPELPEQTTKALPVRFLFTDYNRLSSVGGETSLAEMIATLSDA
CEREFGFLATRLFRVFKTEDTQGKKKWKKTCCLPSFVIFLFIIGCIISGITLLAIFRVDPKHLTVNAVLISIASVVGLAFVLNCRTWWQV
LDSLLNSQRKRLHNAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACEQDKVLQMLDTVRVLFSKGPFIAIF
ASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLSNARKFLVTSATNGDVPCSDTTGIQEDADRRVSQNSLGEMTKLGS
KTALNRRECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASF
HVTCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDDGSFSRDTFPEDI
VSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADII

--------------------------------------------------------------

>42509_42509_4_KIDINS220-KDM4C_KIDINS220_chr2_8918768_ENST00000256707_KDM4C_chr9_7046861_ENST00000535193_length(amino acids)=967AA_BP=907
MQLSVKMSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHV
HIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPL
VWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNI
PDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELL
LDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLGYDLYS
SALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPLFQFSWLIVFLTLLLCGGLGLLFAFTVHPNLGIAVSLSFLA
LLYIFFIVIYFGGRREGESWNWAWVLSTRLARHIGYLELLLKLMFVNPPELPEQTTKALPVRFLFTDYNRLSSVGGETSLAEMIATLSDA
CEREFGFLATRLFRVFKTEDTQGKKKWKKTCCLPSFVIFLFIIGCIISGITLLAIFRVDPKHLTVNAVLISIASVVGLAFVLNCRTWWQV
LDSLLNSQRKRLHNAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACEQDKVLQMLDTVRVLFSKGPFIAIF
ASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLSNARKFLVTSATNGDVPCSDTTGIQEDADRRVSQNSLGEMTKLGS

--------------------------------------------------------------

>42509_42509_5_KIDINS220-KDM4C_KIDINS220_chr2_8918768_ENST00000256707_KDM4C_chr9_7046861_ENST00000543771_length(amino acids)=967AA_BP=907
MQLSVKMSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHV
HIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPL
VWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNI
PDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELL
LDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLGYDLYS
SALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPLFQFSWLIVFLTLLLCGGLGLLFAFTVHPNLGIAVSLSFLA
LLYIFFIVIYFGGRREGESWNWAWVLSTRLARHIGYLELLLKLMFVNPPELPEQTTKALPVRFLFTDYNRLSSVGGETSLAEMIATLSDA
CEREFGFLATRLFRVFKTEDTQGKKKWKKTCCLPSFVIFLFIIGCIISGITLLAIFRVDPKHLTVNAVLISIASVVGLAFVLNCRTWWQV
LDSLLNSQRKRLHNAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACEQDKVLQMLDTVRVLFSKGPFIAIF
ASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLSNARKFLVTSATNGDVPCSDTTGIQEDADRRVSQNSLGEMTKLGS

--------------------------------------------------------------

>42509_42509_6_KIDINS220-KDM4C_KIDINS220_chr2_8918768_ENST00000319688_KDM4C_chr9_7046861_ENST00000381306_length(amino acids)=1202AA_BP=908
MQLSVKMSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHV
HIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLQYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTP
LVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVN
IPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVEL
LLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLGYDLY
SSALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPLFQFSWLIVFLTLLLCGGLGLLFAFTVHPNLGIAVSLSFL
ALLYIFFIVIYFGGRREGESWNWAWVLSTRLARHIGYLELLLKLMFVNPPELPEQTTKALPVRFLFTDYNRLSSVGGETSLAEMIATLSD
ACEREFGFLATRLFRVFKTEDTQGKKKWKKTCCLPSFVIFLFIIGCIISGITLLAIFRVDPKHLTVNAVLISIASVVGLAFVLNCRTWWQ
VLDSLLNSQRKRLHNAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACEQDKVLQMLDTVRVLFSKGPFIAI
FASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLSNARKFLVTSATNGDVPCSDTTGIQEDADRRVSQNSLGEMTKLG
SKTALNRRECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPAS
FHVTCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDDGSFSRDTFPED
IVSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFVSAGRCHLGTCQVNSLS

--------------------------------------------------------------

>42509_42509_7_KIDINS220-KDM4C_KIDINS220_chr2_8918768_ENST00000319688_KDM4C_chr9_7046861_ENST00000381309_length(amino acids)=1211AA_BP=908
MQLSVKMSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHV
HIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLQYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTP
LVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVN
IPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVEL
LLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLGYDLY
SSALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPLFQFSWLIVFLTLLLCGGLGLLFAFTVHPNLGIAVSLSFL
ALLYIFFIVIYFGGRREGESWNWAWVLSTRLARHIGYLELLLKLMFVNPPELPEQTTKALPVRFLFTDYNRLSSVGGETSLAEMIATLSD
ACEREFGFLATRLFRVFKTEDTQGKKKWKKTCCLPSFVIFLFIIGCIISGITLLAIFRVDPKHLTVNAVLISIASVVGLAFVLNCRTWWQ
VLDSLLNSQRKRLHNAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACEQDKVLQMLDTVRVLFSKGPFIAI
FASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLSNARKFLVTSATNGDVPCSDTTGIQEDADRRVSQNSLGEMTKLG
SKTALNRRECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPAS
FHVTCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDDGSFSRDTFPED
IVSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADI

--------------------------------------------------------------

>42509_42509_8_KIDINS220-KDM4C_KIDINS220_chr2_8918768_ENST00000319688_KDM4C_chr9_7046861_ENST00000442236_length(amino acids)=1211AA_BP=908
MQLSVKMSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHV
HIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLQYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTP
LVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVN
IPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVEL
LLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLGYDLY
SSALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPLFQFSWLIVFLTLLLCGGLGLLFAFTVHPNLGIAVSLSFL
ALLYIFFIVIYFGGRREGESWNWAWVLSTRLARHIGYLELLLKLMFVNPPELPEQTTKALPVRFLFTDYNRLSSVGGETSLAEMIATLSD
ACEREFGFLATRLFRVFKTEDTQGKKKWKKTCCLPSFVIFLFIIGCIISGITLLAIFRVDPKHLTVNAVLISIASVVGLAFVLNCRTWWQ
VLDSLLNSQRKRLHNAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACEQDKVLQMLDTVRVLFSKGPFIAI
FASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLSNARKFLVTSATNGDVPCSDTTGIQEDADRRVSQNSLGEMTKLG
SKTALNRRECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPAS
FHVTCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDDGSFSRDTFPED
IVSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADI

--------------------------------------------------------------

>42509_42509_9_KIDINS220-KDM4C_KIDINS220_chr2_8918768_ENST00000319688_KDM4C_chr9_7046861_ENST00000535193_length(amino acids)=968AA_BP=908
MQLSVKMSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHV
HIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLQYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTP
LVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVN
IPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVEL
LLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLGYDLY
SSALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPLFQFSWLIVFLTLLLCGGLGLLFAFTVHPNLGIAVSLSFL
ALLYIFFIVIYFGGRREGESWNWAWVLSTRLARHIGYLELLLKLMFVNPPELPEQTTKALPVRFLFTDYNRLSSVGGETSLAEMIATLSD
ACEREFGFLATRLFRVFKTEDTQGKKKWKKTCCLPSFVIFLFIIGCIISGITLLAIFRVDPKHLTVNAVLISIASVVGLAFVLNCRTWWQ
VLDSLLNSQRKRLHNAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACEQDKVLQMLDTVRVLFSKGPFIAI
FASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLSNARKFLVTSATNGDVPCSDTTGIQEDADRRVSQNSLGEMTKLG

--------------------------------------------------------------

>42509_42509_10_KIDINS220-KDM4C_KIDINS220_chr2_8918768_ENST00000319688_KDM4C_chr9_7046861_ENST00000543771_length(amino acids)=968AA_BP=908
MQLSVKMSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHV
HIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLQYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTP
LVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVN
IPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVEL
LLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLGYDLY
SSALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPLFQFSWLIVFLTLLLCGGLGLLFAFTVHPNLGIAVSLSFL
ALLYIFFIVIYFGGRREGESWNWAWVLSTRLARHIGYLELLLKLMFVNPPELPEQTTKALPVRFLFTDYNRLSSVGGETSLAEMIATLSD
ACEREFGFLATRLFRVFKTEDTQGKKKWKKTCCLPSFVIFLFIIGCIISGITLLAIFRVDPKHLTVNAVLISIASVVGLAFVLNCRTWWQ
VLDSLLNSQRKRLHNAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACEQDKVLQMLDTVRVLFSKGPFIAI
FASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLSNARKFLVTSATNGDVPCSDTTGIQEDADRRVSQNSLGEMTKLG

--------------------------------------------------------------

>42509_42509_11_KIDINS220-KDM4C_KIDINS220_chr2_8918768_ENST00000427284_KDM4C_chr9_7046861_ENST00000381306_length(amino acids)=1201AA_BP=907
MQLSVKMSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHV
HIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPL
VWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNI
PDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELL
LDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLGYDLYS
SALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPLFQFSWLIVFLTLLLCGGLGLLFAFTVHPNLGIAVSLSFLA
LLYIFFIVIYFGGRREGESWNWAWVLSTRLARHIGYLELLLKLMFVNPPELPEQTTKALPVRFLFTDYNRLSSVGGETSLAEMIATLSDA
CEREFGFLATRLFRVFKTEDTQGKKKWKKTCCLPSFVIFLFIIGCIISGITLLAIFRVDPKHLTVNAVLISIASVVGLAFVLNCRTWWQV
LDSLLNSQRKRLHNAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACEQDKVLQMLDTVRVLFSKGPFIAIF
ASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLSNARKFLVTSATNGDVPCSDTTGIQEDADRRVSQNSLGEMTKLGS
KTALNRRECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASF
HVTCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDDGSFSRDTFPEDI
VSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFVSAGRCHLGTCQVNSLSS

--------------------------------------------------------------

>42509_42509_12_KIDINS220-KDM4C_KIDINS220_chr2_8918768_ENST00000427284_KDM4C_chr9_7046861_ENST00000381309_length(amino acids)=1210AA_BP=907
MQLSVKMSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHV
HIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPL
VWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNI
PDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELL
LDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLGYDLYS
SALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPLFQFSWLIVFLTLLLCGGLGLLFAFTVHPNLGIAVSLSFLA
LLYIFFIVIYFGGRREGESWNWAWVLSTRLARHIGYLELLLKLMFVNPPELPEQTTKALPVRFLFTDYNRLSSVGGETSLAEMIATLSDA
CEREFGFLATRLFRVFKTEDTQGKKKWKKTCCLPSFVIFLFIIGCIISGITLLAIFRVDPKHLTVNAVLISIASVVGLAFVLNCRTWWQV
LDSLLNSQRKRLHNAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACEQDKVLQMLDTVRVLFSKGPFIAIF
ASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLSNARKFLVTSATNGDVPCSDTTGIQEDADRRVSQNSLGEMTKLGS
KTALNRRECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASF
HVTCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDDGSFSRDTFPEDI
VSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADII

--------------------------------------------------------------

>42509_42509_13_KIDINS220-KDM4C_KIDINS220_chr2_8918768_ENST00000427284_KDM4C_chr9_7046861_ENST00000442236_length(amino acids)=1210AA_BP=907
MQLSVKMSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHV
HIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPL
VWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNI
PDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELL
LDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLGYDLYS
SALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPLFQFSWLIVFLTLLLCGGLGLLFAFTVHPNLGIAVSLSFLA
LLYIFFIVIYFGGRREGESWNWAWVLSTRLARHIGYLELLLKLMFVNPPELPEQTTKALPVRFLFTDYNRLSSVGGETSLAEMIATLSDA
CEREFGFLATRLFRVFKTEDTQGKKKWKKTCCLPSFVIFLFIIGCIISGITLLAIFRVDPKHLTVNAVLISIASVVGLAFVLNCRTWWQV
LDSLLNSQRKRLHNAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACEQDKVLQMLDTVRVLFSKGPFIAIF
ASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLSNARKFLVTSATNGDVPCSDTTGIQEDADRRVSQNSLGEMTKLGS
KTALNRRECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASF
HVTCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDDGSFSRDTFPEDI
VSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADII

--------------------------------------------------------------

>42509_42509_14_KIDINS220-KDM4C_KIDINS220_chr2_8918768_ENST00000427284_KDM4C_chr9_7046861_ENST00000535193_length(amino acids)=967AA_BP=907
MQLSVKMSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHV
HIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPL
VWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNI
PDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELL
LDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLGYDLYS
SALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPLFQFSWLIVFLTLLLCGGLGLLFAFTVHPNLGIAVSLSFLA
LLYIFFIVIYFGGRREGESWNWAWVLSTRLARHIGYLELLLKLMFVNPPELPEQTTKALPVRFLFTDYNRLSSVGGETSLAEMIATLSDA
CEREFGFLATRLFRVFKTEDTQGKKKWKKTCCLPSFVIFLFIIGCIISGITLLAIFRVDPKHLTVNAVLISIASVVGLAFVLNCRTWWQV
LDSLLNSQRKRLHNAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACEQDKVLQMLDTVRVLFSKGPFIAIF
ASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLSNARKFLVTSATNGDVPCSDTTGIQEDADRRVSQNSLGEMTKLGS

--------------------------------------------------------------

>42509_42509_15_KIDINS220-KDM4C_KIDINS220_chr2_8918768_ENST00000427284_KDM4C_chr9_7046861_ENST00000543771_length(amino acids)=967AA_BP=907
MQLSVKMSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHV
HIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPL
VWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNI
PDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELL
LDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLGYDLYS
SALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPLFQFSWLIVFLTLLLCGGLGLLFAFTVHPNLGIAVSLSFLA
LLYIFFIVIYFGGRREGESWNWAWVLSTRLARHIGYLELLLKLMFVNPPELPEQTTKALPVRFLFTDYNRLSSVGGETSLAEMIATLSDA
CEREFGFLATRLFRVFKTEDTQGKKKWKKTCCLPSFVIFLFIIGCIISGITLLAIFRVDPKHLTVNAVLISIASVVGLAFVLNCRTWWQV
LDSLLNSQRKRLHNAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACEQDKVLQMLDTVRVLFSKGPFIAIF
ASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLSNARKFLVTSATNGDVPCSDTTGIQEDADRRVSQNSLGEMTKLGS

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:8918768/chr9:7046861)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KIDINS220 Q9ULH0	KDM4C Q9H3R0
FUNCTION: Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269\|PubMed:18089783}.	FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269\|PubMed:16603238, ECO:0000269\|PubMed:28262558}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000256707

103_132

901.0

1772.0

Repeat

Note=ANK 4

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000256707

136_165

901.0

1772.0

Repeat

Note=ANK 5

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000256707

169_198

901.0

1772.0

Repeat

Note=ANK 6

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000256707

202_231

901.0

1772.0

Repeat

Note=ANK 7

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000256707

235_264

901.0

1772.0

Repeat

Note=ANK 8

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000256707

268_297

901.0

1772.0

Repeat

Note=ANK 9

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000256707

301_330

901.0

1772.0

Repeat

Note=ANK 10

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000256707

334_363

901.0

1772.0

Repeat

Note=ANK 11

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000256707

367_396

901.0

1772.0

Repeat

Note=ANK 12

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000256707

37_66

901.0

1772.0

Repeat

Note=ANK 2

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000256707

4_33

901.0

1772.0

Repeat

Note=ANK 1

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000256707

70_99

901.0

1772.0

Repeat

Note=ANK 3

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000319688

103_132

902.0

1032.0

Repeat

Note=ANK 4

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000319688

136_165

902.0

1032.0

Repeat

Note=ANK 5

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000319688

169_198

902.0

1032.0

Repeat

Note=ANK 6

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000319688

202_231

902.0

1032.0

Repeat

Note=ANK 7

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000319688

235_264

902.0

1032.0

Repeat

Note=ANK 8

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000319688

268_297

902.0

1032.0

Repeat

Note=ANK 9

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000319688

301_330

902.0

1032.0

Repeat

Note=ANK 10

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000319688

334_363

902.0

1032.0

Repeat

Note=ANK 11

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000319688

367_396

902.0

1032.0

Repeat

Note=ANK 12

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000319688

37_66

902.0

1032.0

Repeat

Note=ANK 2

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000319688

4_33

902.0

1032.0

Repeat

Note=ANK 1

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000319688

70_99

902.0

1032.0

Repeat

Note=ANK 3

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000418530

103_132

859.0

1673.0

Repeat

Note=ANK 4

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000418530

136_165

859.0

1673.0

Repeat

Note=ANK 5

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000418530

169_198

859.0

1673.0

Repeat

Note=ANK 6

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000418530

202_231

859.0

1673.0

Repeat

Note=ANK 7

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000418530

235_264

859.0

1673.0

Repeat

Note=ANK 8

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000418530

268_297

859.0

1673.0

Repeat

Note=ANK 9

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000418530

301_330

859.0

1673.0

Repeat

Note=ANK 10

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000418530

334_363

859.0

1673.0

Repeat

Note=ANK 11

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000418530

367_396

859.0

1673.0

Repeat

Note=ANK 12

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000418530

37_66

859.0

1673.0

Repeat

Note=ANK 2

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000418530

4_33

859.0

1673.0

Repeat

Note=ANK 1

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000418530

70_99

859.0

1673.0

Repeat

Note=ANK 3

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000427284

103_132

901.0

1753.0

Repeat

Note=ANK 4

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000427284

136_165

901.0

1753.0

Repeat

Note=ANK 5

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000427284

169_198

901.0

1753.0

Repeat

Note=ANK 6

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000427284

202_231

901.0

1753.0

Repeat

Note=ANK 7

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000427284

235_264

901.0

1753.0

Repeat

Note=ANK 8

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000427284

268_297

901.0

1753.0

Repeat

Note=ANK 9

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000427284

301_330

901.0

1753.0

Repeat

Note=ANK 10

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000427284

334_363

901.0

1753.0

Repeat

Note=ANK 11

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000427284

367_396

901.0

1753.0

Repeat

Note=ANK 12

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000427284

37_66

901.0

1753.0

Repeat

Note=ANK 2

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000427284

4_33

901.0

1753.0

Repeat

Note=ANK 1

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000427284

70_99

901.0

1753.0

Repeat

Note=ANK 3

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000473731

103_132

901.0

1753.0

Repeat

Note=ANK 4

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000473731

136_165

901.0

1753.0

Repeat

Note=ANK 5

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000473731

169_198

901.0

1753.0

Repeat

Note=ANK 6

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000473731

202_231

901.0

1753.0

Repeat

Note=ANK 7

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000473731

235_264

901.0

1753.0

Repeat

Note=ANK 8

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000473731

268_297

901.0

1753.0

Repeat

Note=ANK 9

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000473731

301_330

901.0

1753.0

Repeat

Note=ANK 10

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000473731

334_363

901.0

1753.0

Repeat

Note=ANK 11

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000473731

367_396

901.0

1753.0

Repeat

Note=ANK 12

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000473731

37_66

901.0

1753.0

Repeat

Note=ANK 2

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000473731

4_33

901.0

1753.0

Repeat

Note=ANK 1

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000473731

70_99

901.0

1753.0

Repeat

Note=ANK 3

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000256707

1_499

901.0

1772.0

Topological domain

Cytoplasmic

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000256707

521_524

901.0

1772.0

Topological domain

Extracellular

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000256707

546_659

901.0

1772.0

Topological domain

Cytoplasmic

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000256707

681_685

901.0

1772.0

Topological domain

Extracellular

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000319688

1_499

902.0

1032.0

Topological domain

Cytoplasmic

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000319688

521_524

902.0

1032.0

Topological domain

Extracellular

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000319688

546_659

902.0

1032.0

Topological domain

Cytoplasmic

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000319688

681_685

902.0

1032.0

Topological domain

Extracellular

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000418530

1_499

859.0

1673.0

Topological domain

Cytoplasmic

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000418530

521_524

859.0

1673.0

Topological domain

Extracellular

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000418530

546_659

859.0

1673.0

Topological domain

Cytoplasmic

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000418530

681_685

859.0

1673.0

Topological domain

Extracellular

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000427284

1_499

901.0

1753.0

Topological domain

Cytoplasmic

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000427284

521_524

901.0

1753.0

Topological domain

Extracellular

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000427284

546_659

901.0

1753.0

Topological domain

Cytoplasmic

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000427284

681_685

901.0

1753.0

Topological domain

Extracellular

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000473731

1_499

901.0

1753.0

Topological domain

Cytoplasmic

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000473731

521_524

901.0

1753.0

Topological domain

Extracellular

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000473731

546_659

901.0

1753.0

Topological domain

Cytoplasmic

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000473731

681_685

901.0

1753.0

Topological domain

Extracellular

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000256707

500_520

901.0

1772.0

Transmembrane

Helical

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000256707

525_545

901.0

1772.0

Transmembrane

Helical

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000256707

660_680

901.0

1772.0

Transmembrane

Helical

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000256707

686_706

901.0

1772.0

Transmembrane

Helical

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000319688

500_520

902.0

1032.0

Transmembrane

Helical

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000319688

525_545

902.0

1032.0

Transmembrane

Helical

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000319688

660_680

902.0

1032.0

Transmembrane

Helical

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000319688

686_706

902.0

1032.0

Transmembrane

Helical

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000418530

500_520

859.0

1673.0

Transmembrane

Helical

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000418530

525_545

859.0

1673.0

Transmembrane

Helical

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000418530

660_680

859.0

1673.0

Transmembrane

Helical

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000418530

686_706

859.0

1673.0

Transmembrane

Helical

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000427284

500_520

901.0

1753.0

Transmembrane

Helical

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000427284

525_545

901.0

1753.0

Transmembrane

Helical

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000427284

660_680

901.0

1753.0

Transmembrane

Helical

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000427284

686_706

901.0

1753.0

Transmembrane

Helical

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000473731

500_520

901.0

1753.0

Transmembrane

Helical

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000473731

525_545

901.0

1753.0

Transmembrane

Helical

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000473731

660_680

901.0

1753.0

Transmembrane

Helical

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000473731

686_706

901.0

1753.0

Transmembrane

Helical

Tgene

KDM4C

chr2:8918768

chr9:7046861

ENST00000381306

877_934

753.0

1048.0

Domain

Note=Tudor 1

Tgene

KDM4C

chr2:8918768

chr9:7046861

ENST00000381306

935_991

753.0

1048.0

Domain

Note=Tudor 2

Tgene

KDM4C

chr2:8918768

chr9:7046861

ENST00000381309

877_934

753.0

1057.0

Domain

Note=Tudor 1

Tgene

KDM4C

chr2:8918768

chr9:7046861

ENST00000381309

935_991

753.0

1057.0

Domain

Note=Tudor 2

Tgene

KDM4C

chr2:8918768

chr9:7046861

ENST00000535193

877_934

775.0

836.0

Domain

Note=Tudor 1

Tgene

KDM4C

chr2:8918768

chr9:7046861

ENST00000535193

935_991

775.0

836.0

Domain

Note=Tudor 2

Tgene

KDM4C

chr2:8918768

chr9:7046861

ENST00000543771

877_934

753.0

814.0

Domain

Note=Tudor 1

Tgene

KDM4C

chr2:8918768

chr9:7046861

ENST00000543771

935_991

753.0

814.0

Domain

Note=Tudor 2

Tgene

KDM4C

chr2:8918768

chr9:7046861

ENST00000381306

752_785

753.0

1048.0

Zinc finger

C2HC pre-PHD-type

Tgene

KDM4C

chr2:8918768

chr9:7046861

ENST00000381306

808_865

753.0

1048.0

Zinc finger

PHD-type 2

Tgene

KDM4C

chr2:8918768

chr9:7046861

ENST00000381309

752_785

753.0

1057.0

Zinc finger

C2HC pre-PHD-type

Tgene

KDM4C

chr2:8918768

chr9:7046861

ENST00000381309

808_865

753.0

1057.0

Zinc finger

PHD-type 2

Tgene

KDM4C

chr2:8918768

chr9:7046861

ENST00000535193

808_865

775.0

836.0

Zinc finger

PHD-type 2

Tgene

KDM4C

chr2:8918768

chr9:7046861

ENST00000543771

752_785

753.0

814.0

Zinc finger

C2HC pre-PHD-type

Tgene

KDM4C

chr2:8918768

chr9:7046861

ENST00000543771

808_865

753.0

814.0

Zinc finger

PHD-type 2

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000256707

440_953

901.0

1772.0

Domain

Note=KAP NTPase

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000319688

440_953

902.0

1032.0

Domain

Note=KAP NTPase

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000418530

440_953

859.0

1673.0

Domain

Note=KAP NTPase

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000427284

440_953

901.0

1753.0

Domain

Note=KAP NTPase

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000473731

440_953

901.0

1753.0

Domain

Note=KAP NTPase

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000256707

1766_1771

901.0

1772.0

Motif

PDZ-binding

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000319688

1766_1771

902.0

1032.0

Motif

PDZ-binding

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000418530

1766_1771

859.0

1673.0

Motif

PDZ-binding

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000427284

1766_1771

901.0

1753.0

Motif

PDZ-binding

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000473731

1766_1771

901.0

1753.0

Motif

PDZ-binding

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000256707

707_1771

901.0

1772.0

Topological domain

Cytoplasmic

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000319688

707_1771

902.0

1032.0

Topological domain

Cytoplasmic

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000418530

707_1771

859.0

1673.0

Topological domain

Cytoplasmic

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000427284

707_1771

901.0

1753.0

Topological domain

Cytoplasmic

Hgene

KIDINS220

chr2:8918768

chr9:7046861

ENST00000473731

707_1771

901.0

1753.0

Topological domain

Cytoplasmic

Tgene

KDM4C

chr2:8918768

chr9:7046861

ENST00000381306

144_310

753.0

1048.0

Domain

JmjC

Tgene

KDM4C

chr2:8918768

chr9:7046861

ENST00000381306

16_58

753.0

1048.0

Domain

JmjN

Tgene

KDM4C

chr2:8918768

chr9:7046861

ENST00000381309

144_310

753.0

1057.0

Domain

JmjC

Tgene

KDM4C

chr2:8918768

chr9:7046861

ENST00000381309

16_58

753.0

1057.0

Domain

JmjN

Tgene

KDM4C

chr2:8918768

chr9:7046861

ENST00000535193

144_310

775.0

836.0

Domain

JmjC

Tgene

KDM4C

chr2:8918768

chr9:7046861

ENST00000535193

16_58

775.0

836.0

Domain

JmjN

Tgene

KDM4C

chr2:8918768

chr9:7046861

ENST00000543771

144_310

753.0

814.0

Domain

JmjC

Tgene

KDM4C

chr2:8918768

chr9:7046861

ENST00000543771

16_58

753.0

814.0

Domain

JmjN

Tgene

KDM4C

chr2:8918768

chr9:7046861

ENST00000381306

689_747

753.0

1048.0

Zinc finger

Note=PHD-type 1

Tgene

KDM4C

chr2:8918768

chr9:7046861

ENST00000381309

689_747

753.0

1057.0

Zinc finger

Note=PHD-type 1

Tgene

KDM4C

chr2:8918768

chr9:7046861

ENST00000535193

689_747

775.0

836.0

Zinc finger

Note=PHD-type 1

Tgene

KDM4C

chr2:8918768

chr9:7046861

ENST00000535193

752_785

775.0

836.0

Zinc finger

C2HC pre-PHD-type

Tgene

KDM4C

chr2:8918768

chr9:7046861

ENST00000543771

689_747

753.0

814.0

Zinc finger

Note=PHD-type 1

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
KIDINS220
KDM4C

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to KIDINS220-KDM4C

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to KIDINS220-KDM4C

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source