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Fusion Protein:KIF15-BCL2L1 |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: KIF15-BCL2L1 | FusionPDB ID: 42568 | FusionGDB2.0 ID: 42568 | Hgene | Tgene | Gene symbol | KIF15 | BCL2L1 | Gene ID | 56992 | 598 |
Gene name | kinesin family member 15 | BCL2 like 1 | |
Synonyms | HKLP2|KLP2|KNSL7|NY-BR-62 | BCL-XL/S|BCL2L|BCLX|Bcl-X|PPP1R52 | |
Cytomap | 3p21.31 | 20q11.21 | |
Type of gene | protein-coding | protein-coding | |
Description | kinesin-like protein KIF15kinesin-like 7kinesin-like protein 2kinesin-like protein 7serologically defined breast cancer antigen NY-BR-62 | bcl-2-like protein 1apoptosis regulator Bcl-Xprotein phosphatase 1, regulatory subunit 52 | |
Modification date | 20200313 | 20200327 | |
UniProtAcc | Q9NS87 | Q9BZR8 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000326047, ENST00000425755, | ENST00000307677, ENST00000376062, ENST00000376055, ENST00000420653, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 3 X 2 X 3=18 | 10 X 5 X 10=500 |
# samples | 3 | 11 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(11/500*10)=-2.18442457113743 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: KIF15 [Title/Abstract] AND BCL2L1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | KIF15(44803376)-BCL2L1(30253889), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | KIF15-BCL2L1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KIF15-BCL2L1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KIF15-BCL2L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KIF15-BCL2L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KIF15-BCL2L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. KIF15-BCL2L1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | BCL2L1 | GO:0001836 | release of cytochrome c from mitochondria | 9843949 |
Tgene | BCL2L1 | GO:0019050 | suppression by virus of host apoptotic process | 15231831 |
Tgene | BCL2L1 | GO:0034097 | response to cytokine | 9184696 |
Tgene | BCL2L1 | GO:0043066 | negative regulation of apoptotic process | 7650367|9388232 |
Tgene | BCL2L1 | GO:0046902 | regulation of mitochondrial membrane permeability | 9843949 |
Tgene | BCL2L1 | GO:0051881 | regulation of mitochondrial membrane potential | 9843949 |
Tgene | BCL2L1 | GO:1900118 | negative regulation of execution phase of apoptosis | 20673843 |
Tgene | BCL2L1 | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | 26582200 |
Tgene | BCL2L1 | GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage | 16608847 |
Tgene | BCL2L1 | GO:1902236 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | 29507230 |
Tgene | BCL2L1 | GO:1903077 | negative regulation of protein localization to plasma membrane | 21041309 |
Tgene | BCL2L1 | GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway | 12011449 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | OV | TCGA-13-0920-01A | KIF15 | chr3 | 44803376 | + | BCL2L1 | chr20 | 30253889 | - |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000326047 | KIF15 | chr3 | 44803376 | + | ENST00000376055 | BCL2L1 | chr20 | 30253889 | - | 1803 | 168 | 1047 | 1631 | 194 |
ENST00000326047 | KIF15 | chr3 | 44803376 | + | ENST00000420653 | BCL2L1 | chr20 | 30253889 | - | 1795 | 168 | 1047 | 1631 | 194 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000326047 | ENST00000376055 | KIF15 | chr3 | 44803376 | + | BCL2L1 | chr20 | 30253889 | - | 0.45809302 | 0.541907 |
ENST00000326047 | ENST00000420653 | KIF15 | chr3 | 44803376 | + | BCL2L1 | chr20 | 30253889 | - | 0.4818373 | 0.5181627 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >42568_42568_1_KIF15-BCL2L1_KIF15_chr3_44803376_ENST00000326047_BCL2L1_chr20_30253889_ENST00000376055_length(amino acids)=194AA_BP= MAPMTILRDQLGPRQMPQSCLWPQLPHFLQEQPVASLPWAAPHGGFRGLSPEVKGSYQEQLWEPQGLPYLRQEGQEGEPAAWGGVGLTRR ASPAWPGRSVPHACPAWAARLPRPEWPGQELFRPPSLFCSTLGLSHPQGSQPPRALCCTYLRLVFIPCEDDILFLLSVSVFMCEELLACS -------------------------------------------------------------- >42568_42568_2_KIF15-BCL2L1_KIF15_chr3_44803376_ENST00000326047_BCL2L1_chr20_30253889_ENST00000420653_length(amino acids)=194AA_BP= MAPMTILRDQLGPRQMPQSCLWPQLPHFLQEQPVASLPWAAPHGGFRGLSPEVKGSYQEQLWEPQGLPYLRQEGQEGEPAAWGGVGLTRR ASPAWPGRSVPHACPAWAARLPRPEWPGQELFRPPSLFCSTLGLSHPQGSQPPRALCCTYLRLVFIPCEDDILFLLSVSVFMCEELLACS -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:44803376/chr20:30253889) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
KIF15 | BCL2L1 |
FUNCTION: Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. {ECO:0000250}. | FUNCTION: Plays a role in apoptosis. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | BCL2L1 | chr3:44803376 | chr20:30253889 | ENST00000376055 | 1 | 3 | 129_148 | 125.0 | 171.0 | Motif | Note=BH1 | |
Tgene | BCL2L1 | chr3:44803376 | chr20:30253889 | ENST00000376055 | 1 | 3 | 180_195 | 125.0 | 171.0 | Motif | Note=BH2 | |
Tgene | BCL2L1 | chr3:44803376 | chr20:30253889 | ENST00000307677 | 1 | 3 | 210_226 | 188.0 | 234.0 | Transmembrane | Helical | |
Tgene | BCL2L1 | chr3:44803376 | chr20:30253889 | ENST00000376055 | 1 | 3 | 210_226 | 125.0 | 171.0 | Transmembrane | Helical | |
Tgene | BCL2L1 | chr3:44803376 | chr20:30253889 | ENST00000376062 | 0 | 2 | 210_226 | 188.0 | 234.0 | Transmembrane | Helical | |
Tgene | BCL2L1 | chr3:44803376 | chr20:30253889 | ENST00000420653 | 1 | 3 | 210_226 | 188.0 | 234.0 | Transmembrane | Helical |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | KIF15 | chr3:44803376 | chr20:30253889 | ENST00000326047 | + | 1 | 35 | 368_1388 | 6.333333333333333 | 1389.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | KIF15 | chr3:44803376 | chr20:30253889 | ENST00000326047 | + | 1 | 35 | 26_363 | 6.333333333333333 | 1389.0 | Domain | Kinesin motor |
Hgene | KIF15 | chr3:44803376 | chr20:30253889 | ENST00000326047 | + | 1 | 35 | 109_116 | 6.333333333333333 | 1389.0 | Nucleotide binding | ATP |
Tgene | BCL2L1 | chr3:44803376 | chr20:30253889 | ENST00000307677 | 1 | 3 | 129_148 | 188.0 | 234.0 | Motif | Note=BH1 | |
Tgene | BCL2L1 | chr3:44803376 | chr20:30253889 | ENST00000307677 | 1 | 3 | 180_195 | 188.0 | 234.0 | Motif | Note=BH2 | |
Tgene | BCL2L1 | chr3:44803376 | chr20:30253889 | ENST00000307677 | 1 | 3 | 4_24 | 188.0 | 234.0 | Motif | Note=BH4 | |
Tgene | BCL2L1 | chr3:44803376 | chr20:30253889 | ENST00000307677 | 1 | 3 | 86_100 | 188.0 | 234.0 | Motif | Note=BH3 | |
Tgene | BCL2L1 | chr3:44803376 | chr20:30253889 | ENST00000376055 | 1 | 3 | 4_24 | 125.0 | 171.0 | Motif | Note=BH4 | |
Tgene | BCL2L1 | chr3:44803376 | chr20:30253889 | ENST00000376055 | 1 | 3 | 86_100 | 125.0 | 171.0 | Motif | Note=BH3 | |
Tgene | BCL2L1 | chr3:44803376 | chr20:30253889 | ENST00000376062 | 0 | 2 | 129_148 | 188.0 | 234.0 | Motif | Note=BH1 | |
Tgene | BCL2L1 | chr3:44803376 | chr20:30253889 | ENST00000376062 | 0 | 2 | 180_195 | 188.0 | 234.0 | Motif | Note=BH2 | |
Tgene | BCL2L1 | chr3:44803376 | chr20:30253889 | ENST00000376062 | 0 | 2 | 4_24 | 188.0 | 234.0 | Motif | Note=BH4 | |
Tgene | BCL2L1 | chr3:44803376 | chr20:30253889 | ENST00000376062 | 0 | 2 | 86_100 | 188.0 | 234.0 | Motif | Note=BH3 | |
Tgene | BCL2L1 | chr3:44803376 | chr20:30253889 | ENST00000420653 | 1 | 3 | 129_148 | 188.0 | 234.0 | Motif | Note=BH1 | |
Tgene | BCL2L1 | chr3:44803376 | chr20:30253889 | ENST00000420653 | 1 | 3 | 180_195 | 188.0 | 234.0 | Motif | Note=BH2 | |
Tgene | BCL2L1 | chr3:44803376 | chr20:30253889 | ENST00000420653 | 1 | 3 | 4_24 | 188.0 | 234.0 | Motif | Note=BH4 | |
Tgene | BCL2L1 | chr3:44803376 | chr20:30253889 | ENST00000420653 | 1 | 3 | 86_100 | 188.0 | 234.0 | Motif | Note=BH3 |
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Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
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Gene | STRING network |
KIF15 | |
BCL2L1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to KIF15-BCL2L1 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to KIF15-BCL2L1 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |