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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:KIF24-ZCCHC7

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: KIF24-ZCCHC7
	FusionPDB ID: 42657
	FusionGDB2.0 ID: 42657
		Hgene	Tgene
	Gene symbol	KIF24	ZCCHC7
	Gene ID	347240	84186
	Gene name	kinesin family member 24	zinc finger CCHC-type containing 7
	Synonyms	C9orf48\|bA571F15.4	AIR1\|HSPC086
	Cytomap	9p13.3	9p13.2
	Type of gene	protein-coding	protein-coding
	Description	kinesin-like protein KIF24	zinc finger CCHC domain-containing protein 7TRAMP-like complex RNA-binding factor ZCCHC7zinc finger, CCHC domain containing 7
	Modification date	20200313	20200320
	UniProtAcc	Q5T7B8	Q8N3Z6
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000379166, ENST00000402558, ENST00000345050, ENST00000379174,	ENST00000461038, ENST00000322831, ENST00000336755, ENST00000534928,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 9 X 4=288	20 X 16 X 8=2560
	# samples	9	22
	** MAII score	log2(9/288*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(22/2560*10)=-3.5405683813627 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: KIF24 [Title/Abstract] AND ZCCHC7 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	KIF24(34286615)-ZCCHC7(37327796), # samples:3
Anticipated loss of major functional domain due to fusion event.	KIF24-ZCCHC7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KIF24-ZCCHC7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KIF24-ZCCHC7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KIF24-ZCCHC7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KIF24-ZCCHC7 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	KIF24	GO:0007019	microtubule depolymerization	21620453

Fusion gene breakpoints across KIF24 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ZCCHC7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCS	TCGA-N8-A56S-01A	KIF24	chr9	34286615	-	ZCCHC7	chr9	37327796	+
ChimerDB4	UCS	TCGA-N8-A56S	KIF24	chr9	34286614	-	ZCCHC7	chr9	37327795	+
ChimerDB4	UCS	TCGA-N8-A56S	KIF24	chr9	34286615	-	ZCCHC7	chr9	37327796	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000402558	KIF24	chr9	34286615	-	ENST00000336755	ZCCHC7	chr9	37327796	+	2802	1240	25	1920	631
ENST00000402558	KIF24	chr9	34286615	-	ENST00000534928	ZCCHC7	chr9	37327796	+	2219	1240	25	1920	631
ENST00000402558	KIF24	chr9	34286614	-	ENST00000336755	ZCCHC7	chr9	37327795	+	2802	1240	25	1920	631
ENST00000402558	KIF24	chr9	34286614	-	ENST00000534928	ZCCHC7	chr9	37327795	+	2219	1240	25	1920	631

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000402558	ENST00000336755	KIF24	chr9	34286615	-	ZCCHC7	chr9	37327796	+	0.00091504	0.99908495
ENST00000402558	ENST00000534928	KIF24	chr9	34286615	-	ZCCHC7	chr9	37327796	+	0.001394423	0.99860555
ENST00000402558	ENST00000336755	KIF24	chr9	34286614	-	ZCCHC7	chr9	37327795	+	0.00091504	0.99908495
ENST00000402558	ENST00000534928	KIF24	chr9	34286614	-	ZCCHC7	chr9	37327795	+	0.001394423	0.99860555

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>42657_42657_1_KIF24-ZCCHC7_KIF24_chr9_34286614_ENST00000402558_ZCCHC7_chr9_37327795_ENST00000336755_length(amino acids)=631AA_BP=386
MASWLYECLCEAELAQYYSHFTALGLQKIDELAKITMKDYSKLGVHDMNDRKRLFQLIKIIKIMQEEDKAVSIPERHLQTSSLRIKSQEL
RSGPRRQLNFDSPADNKDRNASNDGFEMCSLSDFSANEQKSTYLKVLEHMLPDDSQYHTKTGILNATAGDSYVQTEISTSLFSPNYLSAI
LGDCDIPIIQRISHVSGYNYGIPHSCIRQNTSEKQNPWTEMEKIRVCVRKRPLGMREVRRGEINIITVEDKETLLVHEKKEAVDLTQYIL
QHVFYFDEVFGEACTNQDVYMKTTHPLIQHIFNGGNATCFAYGQTGAGKTYTMIGTHENPGLYALAAKDIFRQLEVSQPRKHLFVWISFY
EIYCGQLYDLLNRRKRLFAREDSKHMVQIVGLQELQVDSVELLLEACTEIWRQYHLTTKPGPPKKPKTPSRPSALAYCYHCAQKGHYGHE
CPEREVYDPSPVSPFICYYDDKYEIQEREKRLKQKIKVLKKNGVIPEPSKLPYIKAANENPHHDIRKGRASWKSNRWPQENKETQKEMKN
KNRNWEKHRKADRHREVDEDFPRGPKTYSSPGSFKTQKPSKPFHRSSHYHTSREDKSPKEGKRGKQKKKERCWEDDDNDNLFLIKQRKKK

--------------------------------------------------------------

>42657_42657_2_KIF24-ZCCHC7_KIF24_chr9_34286614_ENST00000402558_ZCCHC7_chr9_37327795_ENST00000534928_length(amino acids)=631AA_BP=386
MASWLYECLCEAELAQYYSHFTALGLQKIDELAKITMKDYSKLGVHDMNDRKRLFQLIKIIKIMQEEDKAVSIPERHLQTSSLRIKSQEL
RSGPRRQLNFDSPADNKDRNASNDGFEMCSLSDFSANEQKSTYLKVLEHMLPDDSQYHTKTGILNATAGDSYVQTEISTSLFSPNYLSAI
LGDCDIPIIQRISHVSGYNYGIPHSCIRQNTSEKQNPWTEMEKIRVCVRKRPLGMREVRRGEINIITVEDKETLLVHEKKEAVDLTQYIL
QHVFYFDEVFGEACTNQDVYMKTTHPLIQHIFNGGNATCFAYGQTGAGKTYTMIGTHENPGLYALAAKDIFRQLEVSQPRKHLFVWISFY
EIYCGQLYDLLNRRKRLFAREDSKHMVQIVGLQELQVDSVELLLEACTEIWRQYHLTTKPGPPKKPKTPSRPSALAYCYHCAQKGHYGHE
CPEREVYDPSPVSPFICYYDDKYEIQEREKRLKQKIKVLKKNGVIPEPSKLPYIKAANENPHHDIRKGRASWKSNRWPQENKETQKEMKN
KNRNWEKHRKADRHREVDEDFPRGPKTYSSPGSFKTQKPSKPFHRSSHYHTSREDKSPKEGKRGKQKKKERCWEDDDNDNLFLIKQRKKK

--------------------------------------------------------------

>42657_42657_3_KIF24-ZCCHC7_KIF24_chr9_34286615_ENST00000402558_ZCCHC7_chr9_37327796_ENST00000336755_length(amino acids)=631AA_BP=386
MASWLYECLCEAELAQYYSHFTALGLQKIDELAKITMKDYSKLGVHDMNDRKRLFQLIKIIKIMQEEDKAVSIPERHLQTSSLRIKSQEL
RSGPRRQLNFDSPADNKDRNASNDGFEMCSLSDFSANEQKSTYLKVLEHMLPDDSQYHTKTGILNATAGDSYVQTEISTSLFSPNYLSAI
LGDCDIPIIQRISHVSGYNYGIPHSCIRQNTSEKQNPWTEMEKIRVCVRKRPLGMREVRRGEINIITVEDKETLLVHEKKEAVDLTQYIL
QHVFYFDEVFGEACTNQDVYMKTTHPLIQHIFNGGNATCFAYGQTGAGKTYTMIGTHENPGLYALAAKDIFRQLEVSQPRKHLFVWISFY
EIYCGQLYDLLNRRKRLFAREDSKHMVQIVGLQELQVDSVELLLEACTEIWRQYHLTTKPGPPKKPKTPSRPSALAYCYHCAQKGHYGHE
CPEREVYDPSPVSPFICYYDDKYEIQEREKRLKQKIKVLKKNGVIPEPSKLPYIKAANENPHHDIRKGRASWKSNRWPQENKETQKEMKN
KNRNWEKHRKADRHREVDEDFPRGPKTYSSPGSFKTQKPSKPFHRSSHYHTSREDKSPKEGKRGKQKKKERCWEDDDNDNLFLIKQRKKK

--------------------------------------------------------------

>42657_42657_4_KIF24-ZCCHC7_KIF24_chr9_34286615_ENST00000402558_ZCCHC7_chr9_37327796_ENST00000534928_length(amino acids)=631AA_BP=386
MASWLYECLCEAELAQYYSHFTALGLQKIDELAKITMKDYSKLGVHDMNDRKRLFQLIKIIKIMQEEDKAVSIPERHLQTSSLRIKSQEL
RSGPRRQLNFDSPADNKDRNASNDGFEMCSLSDFSANEQKSTYLKVLEHMLPDDSQYHTKTGILNATAGDSYVQTEISTSLFSPNYLSAI
LGDCDIPIIQRISHVSGYNYGIPHSCIRQNTSEKQNPWTEMEKIRVCVRKRPLGMREVRRGEINIITVEDKETLLVHEKKEAVDLTQYIL
QHVFYFDEVFGEACTNQDVYMKTTHPLIQHIFNGGNATCFAYGQTGAGKTYTMIGTHENPGLYALAAKDIFRQLEVSQPRKHLFVWISFY
EIYCGQLYDLLNRRKRLFAREDSKHMVQIVGLQELQVDSVELLLEACTEIWRQYHLTTKPGPPKKPKTPSRPSALAYCYHCAQKGHYGHE
CPEREVYDPSPVSPFICYYDDKYEIQEREKRLKQKIKVLKKNGVIPEPSKLPYIKAANENPHHDIRKGRASWKSNRWPQENKETQKEMKN
KNRNWEKHRKADRHREVDEDFPRGPKTYSSPGSFKTQKPSKPFHRSSHYHTSREDKSPKEGKRGKQKKKERCWEDDDNDNLFLIKQRKKK

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:34286615/chr9:37327796)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KIF24 Q5T7B8	ZCCHC7 Q8N3Z6
FUNCTION: Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). {ECO:0000269\|PubMed:21620453}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KIF24

chr9:34286614

chr9:37327795

ENST00000379166

1_64

405.0

1369.0

Domain

SAM

Hgene

KIF24

chr9:34286614

chr9:37327795

ENST00000402558

1_64

405.0

1369.0

Domain

SAM

Hgene

KIF24

chr9:34286615

chr9:37327796

ENST00000379166

1_64

405.0

1369.0

Domain

SAM

Hgene

KIF24

chr9:34286615

chr9:37327796

ENST00000402558

1_64

405.0

1369.0

Domain

SAM

Hgene

KIF24

chr9:34286614

chr9:37327795

ENST00000379166

313_320

405.0

1369.0

Nucleotide binding

ATP

Hgene

KIF24

chr9:34286614

chr9:37327795

ENST00000402558

313_320

405.0

1369.0

Nucleotide binding

ATP

Hgene

KIF24

chr9:34286615

chr9:37327796

ENST00000379166

313_320

405.0

1369.0

Nucleotide binding

ATP

Hgene

KIF24

chr9:34286615

chr9:37327796

ENST00000402558

313_320

405.0

1369.0

Nucleotide binding

ATP

Tgene

ZCCHC7

chr9:34286614

chr9:37327795

ENST00000336755

348_365

317.0

544.0

Zinc finger

CCHC-type 4

Tgene

ZCCHC7

chr9:34286615

chr9:37327796

ENST00000336755

348_365

317.0

544.0

Zinc finger

CCHC-type 4

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KIF24

chr9:34286614

chr9:37327795

ENST00000345050

1_64

1235.0

Domain

SAM

Hgene

KIF24

chr9:34286614

chr9:37327795

ENST00000345050

223_546

1235.0

Domain

Kinesin motor

Hgene

KIF24

chr9:34286614

chr9:37327795

ENST00000379166

223_546

405.0

1369.0

Domain

Kinesin motor

Hgene

KIF24

chr9:34286614

chr9:37327795

ENST00000379174

1_64

1235.0

Domain

SAM

Hgene

KIF24

chr9:34286614

chr9:37327795

ENST00000379174

223_546

1235.0

Domain

Kinesin motor

Hgene

KIF24

chr9:34286614

chr9:37327795

ENST00000402558

223_546

405.0

1369.0

Domain

Kinesin motor

Hgene

KIF24

chr9:34286615

chr9:37327796

ENST00000345050

1_64

1235.0

Domain

SAM

Hgene

KIF24

chr9:34286615

chr9:37327796

ENST00000345050

223_546

1235.0

Domain

Kinesin motor

Hgene

KIF24

chr9:34286615

chr9:37327796

ENST00000379166

223_546

405.0

1369.0

Domain

Kinesin motor

Hgene

KIF24

chr9:34286615

chr9:37327796

ENST00000379174

1_64

1235.0

Domain

SAM

Hgene

KIF24

chr9:34286615

chr9:37327796

ENST00000379174

223_546

1235.0

Domain

Kinesin motor

Hgene

KIF24

chr9:34286615

chr9:37327796

ENST00000402558

223_546

405.0

1369.0

Domain

Kinesin motor

Hgene

KIF24

chr9:34286614

chr9:37327795

ENST00000345050

313_320

1235.0

Nucleotide binding

ATP

Hgene

KIF24

chr9:34286614

chr9:37327795

ENST00000379174

313_320

1235.0

Nucleotide binding

ATP

Hgene

KIF24

chr9:34286615

chr9:37327796

ENST00000345050

313_320

1235.0

Nucleotide binding

ATP

Hgene

KIF24

chr9:34286615

chr9:37327796

ENST00000379174

313_320

1235.0

Nucleotide binding

ATP

Tgene

ZCCHC7

chr9:34286614

chr9:37327795

ENST00000336755

241_258

317.0

544.0

Zinc finger

CCHC-type 1

Tgene

ZCCHC7

chr9:34286614

chr9:37327795

ENST00000336755

263_280

317.0

544.0

Zinc finger

CCHC-type 2

Tgene

ZCCHC7

chr9:34286614

chr9:37327795

ENST00000336755

304_321

317.0

544.0

Zinc finger

CCHC-type 3

Tgene

ZCCHC7

chr9:34286615

chr9:37327796

ENST00000336755

241_258

317.0

544.0

Zinc finger

CCHC-type 1

Tgene

ZCCHC7

chr9:34286615

chr9:37327796

ENST00000336755

263_280

317.0

544.0

Zinc finger

CCHC-type 2

Tgene

ZCCHC7

chr9:34286615

chr9:37327796

ENST00000336755

304_321

317.0

544.0

Zinc finger

CCHC-type 3

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1328_KIF24_34286615_ZCCHC7_37327796_1328_KIF24_34286615_ZCCHC7_37327796_ranked_0.pdb	KIF24	34286614	34286615	ENST00000534928	ZCCHC7	chr9	37327796	+	MASWLYECLCEAELAQYYSHFTALGLQKIDELAKITMKDYSKLGVHDMNDRKRLFQLIKIIKIMQEEDKAVSIPERHLQTSSLRIKSQEL RSGPRRQLNFDSPADNKDRNASNDGFEMCSLSDFSANEQKSTYLKVLEHMLPDDSQYHTKTGILNATAGDSYVQTEISTSLFSPNYLSAI LGDCDIPIIQRISHVSGYNYGIPHSCIRQNTSEKQNPWTEMEKIRVCVRKRPLGMREVRRGEINIITVEDKETLLVHEKKEAVDLTQYIL QHVFYFDEVFGEACTNQDVYMKTTHPLIQHIFNGGNATCFAYGQTGAGKTYTMIGTHENPGLYALAAKDIFRQLEVSQPRKHLFVWISFY EIYCGQLYDLLNRRKRLFAREDSKHMVQIVGLQELQVDSVELLLEACTEIWRQYHLTTKPGPPKKPKTPSRPSALAYCYHCAQKGHYGHE CPEREVYDPSPVSPFICYYDDKYEIQEREKRLKQKIKVLKKNGVIPEPSKLPYIKAANENPHHDIRKGRASWKSNRWPQENKETQKEMKN KNRNWEKHRKADRHREVDEDFPRGPKTYSSPGSFKTQKPSKPFHRSSHYHTSREDKSPKEGKRGKQKKKERCWEDDDNDNLFLIKQRKKK	631

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

KIF24_pLDDT.png

ZCCHC7_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

ZCCHC7

PAPD5, PAPD7, ELAVL1, LYN, SUMO1, SUMO2, PHC1, UBE2I, CARD9, RPL10A, RPL14, PDLIM7, HDLBP, SENP5, EIF2S2, HDGFRP2, ZNHIT6, FAM208A, PPAN, HIST1H1T, KIAA0020, NOL12, DGCR8, RPL28, ZKSCAN1, RNF4, CREBBP, HIST1H4A, KIF9, NEK6, GIPC2, TRIM41, LCE1E, ZNF250, NPM1, MKI67, PRKRA, NEIL1, RPL13, RPL3, RPL36, SART1, CCDC137, RPL11, ZBTB47, SRP14, RPL8, MPHOSPH6, ZNF467, ZC3H10, CPNE2, RPL7A, RPL4, RBM4B, RPLP0,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
KIF24
ZCCHC7

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to KIF24-ZCCHC7

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to KIF24-ZCCHC7

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source