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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:KIF3C-ADCY3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KIF3C-ADCY3
FusionPDB ID: 42706
FusionGDB2.0 ID: 42706
HgeneTgene
Gene symbol

KIF3C

ADCY3

Gene ID

3797

114

Gene namekinesin family member 3Cadenylate cyclase 8
Synonyms-AC8|ADCY3|HBAC1
Cytomap

2p23.3

8q24.22

Type of geneprotein-codingprotein-coding
Descriptionkinesin-like protein KIF3CKIF3C variant proteinadenylate cyclase type 8ATP pyrophosphate-lyase 8HEL-S-172mPadenylate cyclase 8 (brain)adenylate cyclase type VIIIadenylyl cyclase 8adenylyl cyclase-8, brainca(2+)/calmodulin-activated adenylyl cyclaseepididymis secretory sperm binding protein Li
Modification date2020031320200313
UniProtAcc

O14782

O60266

Ensembl transtripts involved in fusion geneENST idsENST00000264712, ENST00000405914, 
ENST00000496378, 		ENST00000405392, 
ENST00000450524, ENST00000260600, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 5 X 4=1403 X 3 X 3=27
# samples 94
** MAII scorelog2(9/140*10)=-0.637429920615292
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: KIF3C [Title/Abstract] AND ADCY3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KIF3C(26203242)-ADCY3(25095588), # samples:3
Anticipated loss of major functional domain due to fusion event.KIF3C-ADCY3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KIF3C-ADCY3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KIF3C-ADCY3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KIF3C-ADCY3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KIF3C-ADCY3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KIF3C-ADCY3 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
KIF3C-ADCY3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across KIF3C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ADCY3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-59-A5PD-01AKIF3Cchr2

26203242

-ADCY3chr2

25095588

-
ChimerDB4OVTCGA-59-A5PDKIF3Cchr2

26203241

-ADCY3chr2

25095588

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264712KIF3Cchr226203242-ENST00000260600ADCY3chr225095588-5648212558048841434
ENST00000264712KIF3Cchr226203241-ENST00000260600ADCY3chr225095588-5648212558048841434

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264712ENST00000260600KIF3Cchr226203242-ADCY3chr225095588-0.0078151930.9921848
ENST00000264712ENST00000260600KIF3Cchr226203241-ADCY3chr225095588-0.0078151930.9921848

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>42706_42706_1_KIF3C-ADCY3_KIF3C_chr2_26203241_ENST00000264712_ADCY3_chr2_25095588_ENST00000260600_length(amino acids)=1434AA_BP=0
MASKTKASEALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPRAAPGELPKTFTFDAVYDASSKQADLYDETVRPLIDSVLQGFN
GTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAFEHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKEPGKRLELKENPETGVYIKDL
SSFVTKNVKEIEHVMNLGNQTRAVGSTHMNEVSSRSHAIFIITVECSERGSDGQDHIRVGKLNLVDLAGSERQNKAGPNTAGGAATPSSG
GGGGGGGSGGGAGGERPKEASKINLSLSALGNVIAALAGNRSTHIPYRDSKLTRLLQDSLGGNAKTIMVATLGPASHSYDESLSTLRFAN
RAKNIKNKPQVNEDPKDTLLREFQEEIARLKAQLEKRGMLGKRPRRKSSRRKKAVSAPPGYPEGPVIEAWVAEEEDDNNNNHRPPQPILE
SALEKNMENYLQEQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDLRREQQATELLAAKYKILANVFLYLCAIAVGIMSYYMADRK
HRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQEL
VKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRW
QYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPAS
SKSSSPALIETKEPNGSAHSSGSTSEKPEEQDAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFL
LSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAIFPRAFPKKLVAFSTWIDR
TRWARNTWAMLAIFILVMANVVDMLSCLQYYTGPSNATAGMETEGSCLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATI
NLYAWRPVFDEYDHKRFREHDLPMVALEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKER
VYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRV
ITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPH

--------------------------------------------------------------

>42706_42706_2_KIF3C-ADCY3_KIF3C_chr2_26203242_ENST00000264712_ADCY3_chr2_25095588_ENST00000260600_length(amino acids)=1434AA_BP=0
MASKTKASEALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPRAAPGELPKTFTFDAVYDASSKQADLYDETVRPLIDSVLQGFN
GTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAFEHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKEPGKRLELKENPETGVYIKDL
SSFVTKNVKEIEHVMNLGNQTRAVGSTHMNEVSSRSHAIFIITVECSERGSDGQDHIRVGKLNLVDLAGSERQNKAGPNTAGGAATPSSG
GGGGGGGSGGGAGGERPKEASKINLSLSALGNVIAALAGNRSTHIPYRDSKLTRLLQDSLGGNAKTIMVATLGPASHSYDESLSTLRFAN
RAKNIKNKPQVNEDPKDTLLREFQEEIARLKAQLEKRGMLGKRPRRKSSRRKKAVSAPPGYPEGPVIEAWVAEEEDDNNNNHRPPQPILE
SALEKNMENYLQEQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDLRREQQATELLAAKYKILANVFLYLCAIAVGIMSYYMADRK
HRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQEL
VKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRW
QYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPAS
SKSSSPALIETKEPNGSAHSSGSTSEKPEEQDAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFL
LSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAIFPRAFPKKLVAFSTWIDR
TRWARNTWAMLAIFILVMANVVDMLSCLQYYTGPSNATAGMETEGSCLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATI
NLYAWRPVFDEYDHKRFREHDLPMVALEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKER
VYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRV
ITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPH

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:26203242/chr2:25095588)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF3C

O14782

ADCY3

O60266

FUNCTION: Microtubule-based anterograde translocator for membranous organelles. {ECO:0000250}.FUNCTION: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet. {ECO:0000250|UniProtKB:Q8VHH7}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIF3Cchr2:26203241chr2:25095588ENST00000264712-18270_284515.0794.0Compositional biasNote=Poly-Gly
HgeneKIF3Cchr2:26203241chr2:25095588ENST00000264712-18438_441515.0794.0Compositional biasNote=Poly-Asn
HgeneKIF3Cchr2:26203241chr2:25095588ENST00000405914-29270_284515.0794.0Compositional biasNote=Poly-Gly
HgeneKIF3Cchr2:26203241chr2:25095588ENST00000405914-29438_441515.0794.0Compositional biasNote=Poly-Asn
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000264712-18270_284515.0794.0Compositional biasNote=Poly-Gly
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000264712-18438_441515.0794.0Compositional biasNote=Poly-Asn
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000405914-29270_284515.0794.0Compositional biasNote=Poly-Gly
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000405914-29438_441515.0794.0Compositional biasNote=Poly-Asn
HgeneKIF3Cchr2:26203241chr2:25095588ENST00000264712-1810_365515.0794.0DomainKinesin motor
HgeneKIF3Cchr2:26203241chr2:25095588ENST00000405914-2910_365515.0794.0DomainKinesin motor
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000264712-1810_365515.0794.0DomainKinesin motor
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000405914-2910_365515.0794.0DomainKinesin motor
HgeneKIF3Cchr2:26203241chr2:25095588ENST00000264712-1897_104515.0794.0Nucleotide bindingNote=ATP
HgeneKIF3Cchr2:26203241chr2:25095588ENST00000405914-2997_104515.0794.0Nucleotide bindingNote=ATP
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000264712-1897_104515.0794.0Nucleotide bindingNote=ATP
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000405914-2997_104515.0794.0Nucleotide bindingNote=ATP
TgeneADCY3chr2:26203241chr2:25095588ENST000002606000211062_1064225.01145.0Nucleotide bindingATP
TgeneADCY3chr2:26203241chr2:25095588ENST000002606000211069_1073225.01145.0Nucleotide bindingATP
TgeneADCY3chr2:26203241chr2:25095588ENST00000260600021324_329225.01145.0Nucleotide bindingATP
TgeneADCY3chr2:26203241chr2:25095588ENST00000260600021366_368225.01145.0Nucleotide bindingATP
TgeneADCY3chr2:26203242chr2:25095588ENST000002606000211062_1064225.01145.0Nucleotide bindingATP
TgeneADCY3chr2:26203242chr2:25095588ENST000002606000211069_1073225.01145.0Nucleotide bindingATP
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600021324_329225.01145.0Nucleotide bindingATP
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600021366_368225.01145.0Nucleotide bindingATP
TgeneADCY3chr2:26203241chr2:25095588ENST00000260600021402_632225.01145.0Topological domainCytoplasmic
TgeneADCY3chr2:26203241chr2:25095588ENST00000260600021854_1144225.01145.0Topological domainCytoplasmic
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600021402_632225.01145.0Topological domainCytoplasmic
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600021854_1144225.01145.0Topological domainCytoplasmic
TgeneADCY3chr2:26203241chr2:25095588ENST00000260600021226_246225.01145.0TransmembraneHelical
TgeneADCY3chr2:26203241chr2:25095588ENST00000260600021381_401225.01145.0TransmembraneHelical
TgeneADCY3chr2:26203241chr2:25095588ENST00000260600021633_653225.01145.0TransmembraneHelical
TgeneADCY3chr2:26203241chr2:25095588ENST00000260600021664_684225.01145.0TransmembraneHelical
TgeneADCY3chr2:26203241chr2:25095588ENST00000260600021708_728225.01145.0TransmembraneHelical
TgeneADCY3chr2:26203241chr2:25095588ENST00000260600021754_774225.01145.0TransmembraneHelical
TgeneADCY3chr2:26203241chr2:25095588ENST00000260600021775_795225.01145.0TransmembraneHelical
TgeneADCY3chr2:26203241chr2:25095588ENST00000260600021833_853225.01145.0TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600021226_246225.01145.0TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600021381_401225.01145.0TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600021633_653225.01145.0TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600021664_684225.01145.0TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600021708_728225.01145.0TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600021754_774225.01145.0TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600021775_795225.01145.0TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600021833_853225.01145.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIF3Cchr2:26203241chr2:25095588ENST00000264712-18376_629515.0794.0Coiled coilOntology_term=ECO:0000255
HgeneKIF3Cchr2:26203241chr2:25095588ENST00000405914-29376_629515.0794.0Coiled coilOntology_term=ECO:0000255
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000264712-18376_629515.0794.0Coiled coilOntology_term=ECO:0000255
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000405914-29376_629515.0794.0Coiled coilOntology_term=ECO:0000255
HgeneKIF3Cchr2:26203241chr2:25095588ENST00000264712-18630_793515.0794.0RegionGlobular
HgeneKIF3Cchr2:26203241chr2:25095588ENST00000405914-29630_793515.0794.0RegionGlobular
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000264712-18630_793515.0794.0RegionGlobular
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000405914-29630_793515.0794.0RegionGlobular
TgeneADCY3chr2:26203241chr2:25095588ENST000002606000211_79225.01145.0Topological domainCytoplasmic
TgeneADCY3chr2:26203242chr2:25095588ENST000002606000211_79225.01145.0Topological domainCytoplasmic
TgeneADCY3chr2:26203241chr2:25095588ENST00000260600021105_125225.01145.0TransmembraneHelical
TgeneADCY3chr2:26203241chr2:25095588ENST00000260600021139_159225.01145.0TransmembraneHelical
TgeneADCY3chr2:26203241chr2:25095588ENST00000260600021173_193225.01145.0TransmembraneHelical
TgeneADCY3chr2:26203241chr2:25095588ENST0000026060002180_100225.01145.0TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600021105_125225.01145.0TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600021139_159225.01145.0TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600021173_193225.01145.0TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST0000026060002180_100225.01145.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KIF3C
ADCY3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to KIF3C-ADCY3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KIF3C-ADCY3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource